GABA Receptor

信号通路图

研究领域

  • 抑制剂选择性比较
  • 溶解性比较
目录号 产品目录 溶解度(25°C)
DMSO 酒精
S1168 Valproic acid sodium salt (Sodium valproate) 33 mg/mL 33 mg/mL 33 mg/mL
S1332 Flumazenil <1 mg/mL 5 mg/mL <1 mg/mL
S1338 Gabapentin HCl 42 mg/mL <1 mg/mL <1 mg/mL
S1329 Etomidate <1 mg/mL 49 mg/mL 49 mg/mL
S2133 Gabapentin 34 mg/mL <1 mg/mL <1 mg/mL
S3786 Glabridin -1 mg/mL 64 mg/mL -1 mg/mL
S3748 Acamprosate Calcium 40 mg/mL <1 mg/mL <1 mg/mL
S3663 Afloqualone <1 mg/mL 56 mg/mL 28 mg/mL
S3634 6-Hydroxyflavone (6-HF) <1 mg/mL 47 mg/mL <1 mg/mL
S7071 (+)-Bicuculline <1 mg/mL 21 mg/mL <1 mg/mL
S1969 Nefiracetam 5 mg/mL 49 mg/mL 49 mg/mL
S3072 (R)-baclofen 8 mg/mL <1 mg/mL <1 mg/mL
S3018 Niflumic acid <1 mg/mL 56 mg/mL <1 mg/mL
S4574 Piperazine 17 mg/mL 8 mg/mL 17 mg/mL
S2026 Ginkgolide A <1 mg/mL 81 mg/mL 2 mg/mL
S4587 Pentylenetetrazol 27 mg/mL 27 mg/mL 27 mg/mL
S2269 Baicalin <1 mg/mL 89 mg/mL <1 mg/mL
S4645 Armodafinil <1 mg/mL 54 mg/mL 20 mg/mL
S2399 Dihydromyricetin <1 mg/mL 64 mg/mL 64 mg/mL
S4661 Tiagabine hydrochloride 11 mg/mL 82 mg/mL 82 mg/mL
S4197 Bemegride <1 mg/mL 31 mg/mL 31 mg/mL
S4270 Oxiracetam 31 mg/mL 31 mg/mL <1 mg/mL
S4700 4-Aminobutyric acid 20 mg/mL <1 mg/mL <1 mg/mL

特异性亚型抑制剂

产品目录 产品描述 文献引用 实验数据
S1168

Valproic acid sodium salt (Sodium valproate)

Valproic acid sodium salt (Sodium valproate)是一种HDAC选择性抑制剂,也会抑制HDAC2的蛋白酶体降解,用于治疗癫痫和躁郁症,并预防偏头痛。

S1332

Flumazenil

Flumazenil是一种苯二氮卓类拮抗剂。

S1338

Gabapentin HCl

Gabapentin HCl是一种GABA类似物。

S1329

Etomidate

Etomidate是一种GABAA受体激动剂, 用作短效的麻醉剂或者安定剂。

S2133

Gabapentin

Gabapentin 是一种GABA类似物,用于治疗癫痫及神经痛。

S5131New

Homotaurine

Homotaurine is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.

S3786New

Glabridin

Glabridin, one of the active phytochemicals in licorice extract, binds to and activates the ligand binding domain of PPARγ, as well as the full length receptor. It is also a GABAA receptor positive modulator promoting fatty acid oxidation and improving learning and memory.

S3748New

Acamprosate Calcium

Acamprosate, calcium acetylhomotaurinate, is a synthetic compound with a chemical structure similar to the amino acid neurotransmitter gamma-aminobutyric acid (GABA) and the amino acid neuromodulator taurine.

S3663New

Afloqualone

Afloqualone (AFQ) is a quinazolinone family GABAergic drug with muscle-relaxant and sedative effects, showing the agonist activity at the β subtype of the GABAa receptor.

S3634New

6-Hydroxyflavone (6-HF)

6-Hydroxyflavone是一种天然类黄酮,与GABAA receptors结合,是GABAA receptors的部分激动剂。

S7071

(+)-Bicuculline

(+)-Bicuculline是一种竞争性GABAA受体拮抗剂,IC50为2 μM,也抑制Ca(2+)激活的钾离子通道。

S1969

Nefiracetam

Nefiracetam作用于Ro 5-4864引起的抽搐,是GABAergic,胆碱及单胺类的神经系统增强剂。Phase 2。

S3072

(R)-baclofen

(R)-baclofen是一种γ-氨基丁酸衍生物,主要用于治疗痉挛。

S3018

Niflumic acid

Niflumic acid是环氧合酶-2 (COX-2)抑制剂,用于治疗关节和肌肉疼痛。

S4574

Piperazine

Piperazine是GABA受体的激动剂,是一种用于治疗肠道线虫蛔虫和蛲虫的驱虫剂。

S2026

Ginkgolide A

Ginkgolide A是银杏的提取物,是γ-氨基丁酸(GABA)拮抗剂,Ki为14.5 μM。

S4587

Pentylenetetrazol

Pentylenetetrazol是中枢神经系统和呼吸系统兴奋剂。是一种非竞争性地GABA(A)受体拮抗剂。

S2269

Baicalin

Baicalin 是一种脯氨酰肽链内切酶抑制剂,影响GABA受体。

S4645

Armodafinil

Armodafinil是外消旋合成产物modafinil的 r-对映体,具有兴奋中枢神经系统和催醒的活性。

S2399

Dihydromyricetin

Dihydromyricetin 是具有良好性能的天然抗氧化剂。

S4661

Tiagabine hydrochloride

Tiagabine Hydrochloride是tiagabine的盐酸盐形式,是哌啶甲酸衍生物,具有抗惊厥作用,它是选择性的GABA重吸收抑制剂。

S4675

Tiagabine

Tiagabine是一种抗惊厥的药物,是GABA重吸收的抑制剂。

S4197

Bemegride

Bemegride是一种中枢神经系统兴奋剂,及Barbiturate中毒的解毒剂。

S4270

Oxiracetam

Oxiracetam,γ-氨基丁酸的环状衍生物(GABA),作为益智药用以改善记忆力和学习。

S4700

4-Aminobutyric acid

γ-氨基丁酸(GABA)是一种天然存在的神经递质,具有抑制中枢神经系统的活性。

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