DNA Methyltransferase

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DNA Methyltransferase信号通路图

DNA Methyltransferase产品

  • 所有产品(17)
  • DNA Methyltransferase抑制剂 (16)
  • DNA Methyltransferase抗体 (1)
目录号 产品名 产品描述 文献引用 实验数据
S1200 Decitabine Decitabine是DNA甲基转移酶抑制剂,整合进入DNA、导致DNA低甲基化,并使DNA复制停滞在intra-S-phase。Decitabine被用于治疗骨髓增生异常综合征(MDS)。Decitabine可在多种癌细胞系中诱导细胞周期阻滞和凋亡。
Cell Rep Med, 2024, 5(2):101416
NPJ Precis Oncol, 2024, 8(1):52
iScience, 2024, 27(1):108667
S1782 Azacitidine (5-Azacytidine) Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) 是胞苷的核苷类似物,通过捕获DNA甲基转移酶,特异性抑制DNA甲基化。Azacitidine可诱导线粒体凋亡与自噬。
Nat Commun, 2024, 15(1):1750
Cell Rep Med, 2024, 5(2):101416
Biochem Pharmacol, 2024, S0006-2952(24)00048-0
S2250 EGCG ((-)-Epigallocatechin Gallate) EGCG ((-)-Epigallocatechin Gallate)是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomeraseDNA methyltransferase, 阻滞EGF受体HER-2受体的激活,抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。
Journal of Functional Foods, 2024, 105977
Cell Rep Med, 2023, 4(5):101026
Transl Oncol, 2023, 35:101712
S2821 RG108 RG108 (N-Phthalyl-L-tryptophan)是一种DNA methyltransferase抑制剂,无细胞试验中IC50为115 nM,不会引起共价酶的诱捕。
Neural Regeneration Research, 2024, 19(10):p 2229-2239
Hereditas, 2023, 160(1):18
Cell Stem Cell, 2022, 29(8):1229-1245.e7
S1774 Thioguanine Thioguanine是一种嘌呤类的抗代谢药物,抑制了DNMT1的活性,广泛用于治疗急性淋巴细胞白血病,自身免疫性疾病(如克罗恩氏病,类风湿关节炎)和器官移植接受患者。
Gastroenterology, 2024, S0016-5085(24)00062-3
Cancer Cell, 2023, 41(1):196-209.e5
Nat Commun, 2022, 13(1):6226
S7276 SGI-1027 SGI-1027 (DNA Methyltransferase Inhibitor II) 是一种DNMT抑制剂,作用于DNMT1,DNMT3A和DNMT3B,无细胞试验中IC50分别为6,8和7.5 μM。SGI‑1027 可诱导凋亡。
Int J Biol Sci, 2022, 18(11):4372-4387
Cancers (Basel), 2022, 14(19)4883
Head Neck, 2022, 44(5):1192-1205
S7113 Zebularine (NSC 309132) Zebularine (NSC 309132, 4-Deoxyuridine)是一种DNA methylation抑制剂,与DNA methyltransferases形成共价复合物,也抑制胞苷脱氨酶,无细胞试验中Ki为2 μM。
Leukemia, 2022, 10.1038/s41375-022-01746-3
J Transl Med, 2022, 20(1):383
Plant Physiol, 2022, 190(2):1490-1505
S3957 Gamma-Oryzanol Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass.
Nutrients, 2023, 15(16)3630
Nutrients, 2023, 15(16)3630
Cell Death Dis, 2021, 12(2):188
S6682 Bobcat339 hydrochloride Bobcat339是一种选择性的基于胞嘧啶的TET enzyme抑制剂,对于TET1TET2的IC50分别为33 μM和73 μM。Bobcat339可通过抑制活细胞中的TET酶功能来降低DNA 5-羟甲基胞嘧啶的丰度,并为其实用的药理探针提供支持。
Cell Commun Signal, 2024, 22(1):95
Neural Regeneration Research, 2024, 19(10):p 2229-2239
Int J Mol Sci, 2023, 24(15)12455
S8812 CM272 CM272是新型、一流的G9a (GLP)DNMTs双重可逆抑制剂,对G9a, DNMT1, DNMT3A, DNMT3B, GLP的IC50值分别为8 nM, 382 nM, 85 nM, 1200 nM, 2 nM。CM272通过至少部分诱导免疫原性细胞死亡,延长了血液系统恶性肿瘤体内模型的存活时间。
Hepatol Commun, 2024, 8(2)e0378
Nat Med, 2019, 25(7):1073-1081
E1046 GSK3685032 GSK3685032是一种非时间依赖性、高度选择性的 DNA 甲基转移酶 (DNMT1) 抑制剂,IC50值为0.036 μM,其作用于DNMT1比作用于DNMT3A/3L 和 DNMT3B/3L选择性高2500倍。
Nat Commun, 2023, 14(1):3966
S4771 β-thujaplicin β-Thujaplicin (β-TH, Hinokitiol, 4-Isopropyltropolone) is a toxic tropolone derivative present in the heartwood of western red cedar (Thuja plicata) and is used as a preservative and antimicrobial additive in a number of commercial goods. Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.
Invest New Drugs, 2022, 10.1007/s10637-022-01229-3
S3543 DC-05 DC-05为DNA甲基转移酶1(DNA methyltransferase 1, DNMT1)抑制剂,IC50为10.3 μM, Kd为1.09 μM。
A5700 Dnmt1 Rabbit Recombinant mAb
S4294 Procainamide HCl Procainamide HCl是一种sodium channel的阻断剂,也是DNA甲基转移酶抑制剂,用于心律失常的治疗。
A5984 Dnmt3a Rabbit Recombinant mAb
S2477 2'-Deoxy-5-Fluorocytidine 2'-Deoxy-5-fluorocytidine (5-fluoro-2(')-deoxycytidine, FCdR)是一种嘧啶类似物,是目前应用于实体瘤临床试验中的一种 DNA methyltransferase (DMNT) 抑制剂。
A5984 Dnmt3a Rabbit Recombinant mAb
S1200 Decitabine Decitabine是DNA甲基转移酶抑制剂,整合进入DNA、导致DNA低甲基化,并使DNA复制停滞在intra-S-phase。Decitabine被用于治疗骨髓增生异常综合征(MDS)。Decitabine可在多种癌细胞系中诱导细胞周期阻滞和凋亡。
Cell Rep Med, 2024, 5(2):101416
NPJ Precis Oncol, 2024, 8(1):52
iScience, 2024, 27(1):108667
S1782 Azacitidine (5-Azacytidine) Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) 是胞苷的核苷类似物,通过捕获DNA甲基转移酶,特异性抑制DNA甲基化。Azacitidine可诱导线粒体凋亡与自噬。
Nat Commun, 2024, 15(1):1750
Cell Rep Med, 2024, 5(2):101416
Biochem Pharmacol, 2024, S0006-2952(24)00048-0
S2250 EGCG ((-)-Epigallocatechin Gallate) EGCG ((-)-Epigallocatechin Gallate)是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomeraseDNA methyltransferase, 阻滞EGF受体HER-2受体的激活,抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。
Journal of Functional Foods, 2024, 105977
Cell Rep Med, 2023, 4(5):101026
Transl Oncol, 2023, 35:101712
S2821 RG108 RG108 (N-Phthalyl-L-tryptophan)是一种DNA methyltransferase抑制剂,无细胞试验中IC50为115 nM,不会引起共价酶的诱捕。
Neural Regeneration Research, 2024, 19(10):p 2229-2239
Hereditas, 2023, 160(1):18
Cell Stem Cell, 2022, 29(8):1229-1245.e7
S1774 Thioguanine Thioguanine是一种嘌呤类的抗代谢药物,抑制了DNMT1的活性,广泛用于治疗急性淋巴细胞白血病,自身免疫性疾病(如克罗恩氏病,类风湿关节炎)和器官移植接受患者。
Gastroenterology, 2024, S0016-5085(24)00062-3
Cancer Cell, 2023, 41(1):196-209.e5
Nat Commun, 2022, 13(1):6226
S7276 SGI-1027 SGI-1027 (DNA Methyltransferase Inhibitor II) 是一种DNMT抑制剂,作用于DNMT1,DNMT3A和DNMT3B,无细胞试验中IC50分别为6,8和7.5 μM。SGI‑1027 可诱导凋亡。
Int J Biol Sci, 2022, 18(11):4372-4387
Cancers (Basel), 2022, 14(19)4883
Head Neck, 2022, 44(5):1192-1205
S7113 Zebularine (NSC 309132) Zebularine (NSC 309132, 4-Deoxyuridine)是一种DNA methylation抑制剂,与DNA methyltransferases形成共价复合物,也抑制胞苷脱氨酶,无细胞试验中Ki为2 μM。
Leukemia, 2022, 10.1038/s41375-022-01746-3
J Transl Med, 2022, 20(1):383
Plant Physiol, 2022, 190(2):1490-1505
S3957 Gamma-Oryzanol Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass.
Nutrients, 2023, 15(16)3630
Nutrients, 2023, 15(16)3630
Cell Death Dis, 2021, 12(2):188
S6682 Bobcat339 hydrochloride Bobcat339是一种选择性的基于胞嘧啶的TET enzyme抑制剂,对于TET1TET2的IC50分别为33 μM和73 μM。Bobcat339可通过抑制活细胞中的TET酶功能来降低DNA 5-羟甲基胞嘧啶的丰度,并为其实用的药理探针提供支持。
Cell Commun Signal, 2024, 22(1):95
Neural Regeneration Research, 2024, 19(10):p 2229-2239
Int J Mol Sci, 2023, 24(15)12455
S8812 CM272 CM272是新型、一流的G9a (GLP)DNMTs双重可逆抑制剂,对G9a, DNMT1, DNMT3A, DNMT3B, GLP的IC50值分别为8 nM, 382 nM, 85 nM, 1200 nM, 2 nM。CM272通过至少部分诱导免疫原性细胞死亡,延长了血液系统恶性肿瘤体内模型的存活时间。
Hepatol Commun, 2024, 8(2)e0378
Nat Med, 2019, 25(7):1073-1081
E1046 GSK3685032 GSK3685032是一种非时间依赖性、高度选择性的 DNA 甲基转移酶 (DNMT1) 抑制剂,IC50值为0.036 μM,其作用于DNMT1比作用于DNMT3A/3L 和 DNMT3B/3L选择性高2500倍。
Nat Commun, 2023, 14(1):3966
S4771 β-thujaplicin β-Thujaplicin (β-TH, Hinokitiol, 4-Isopropyltropolone) is a toxic tropolone derivative present in the heartwood of western red cedar (Thuja plicata) and is used as a preservative and antimicrobial additive in a number of commercial goods. Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.
Invest New Drugs, 2022, 10.1007/s10637-022-01229-3
S3543 DC-05 DC-05为DNA甲基转移酶1(DNA methyltransferase 1, DNMT1)抑制剂,IC50为10.3 μM, Kd为1.09 μM。
S4294 Procainamide HCl Procainamide HCl是一种sodium channel的阻断剂,也是DNA甲基转移酶抑制剂,用于心律失常的治疗。
S2477 2'-Deoxy-5-Fluorocytidine 2'-Deoxy-5-fluorocytidine (5-fluoro-2(')-deoxycytidine, FCdR)是一种嘧啶类似物,是目前应用于实体瘤临床试验中的一种 DNA methyltransferase (DMNT) 抑制剂。
A5700 Dnmt1 Rabbit Recombinant mAb

DNA Methyltransferase抑制剂选择性比较

Tags: DNA Methyltransferase inhibitor|DNA Methyltransferase agonist|DNA Methyltransferase activator|DNA Methyltransferase inducer|DNA Methyltransferase antagonist|DNA Methyltransferase signaling pathway|DNA Methyltransferase assay kit
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