DNA Methyltransferase
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S1200 | Decitabine | 10 mg/mL | 45 mg/mL | <1 mg/mL |
| S1782 | Azacitidine | <1 mg/mL | 48 mg/mL | <1 mg/mL |
| S2821 | RG108 | <1 mg/mL | 67 mg/mL | 67 mg/mL |
| S7113 | Zebularine | 46 mg/mL | 46 mg/mL | <1 mg/mL |
| S1774 | Thioguanine | <1 mg/mL | 9 mg/mL | <1 mg/mL |
| S7276 | SGI-1027 | <1 mg/mL | 92 mg/mL | <1 mg/mL |
| S2250 | (-)-Epigallocatechin Gallate | 23 mg/mL | 72 mg/mL | 83 mg/mL |
| S4294 | Procainamide HCl | 54 mg/mL | 54 mg/mL | 54 mg/mL |
- DNA Methyltransferase抑制剂（8）
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1200 |
DecitabineDecitabine是DNA甲基转移酶抑制剂，整合进入DNA、导致DNA低甲基化，并使DNA复制停滞在intra-S-phase。Decitabine被用于治疗骨髓增生异常综合征(MDS）。 |
(A) and (B) SW1116 and LOVO cells were plated, treated for 48 h with decitabine (DAC) and gefitinib (GEF) either alone or in combination, and the expression levels of AKT, mTOR, S6K, and phosphorylation were determined by Western blot analysis as described under Methods. Expression of β-actin served as a loading control. The data are representative of three independent experiments.
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| S1782 |
AzacitidineAzacitidine 是胞苷的核苷类似物，通过捕获DNA甲基转移酶，特异性抑制DNA甲基化。 |
R-2HG treatment or chemotherapeutic treatment, especially their combinations, decrease MYC levels in leukemic cells (using MONOMAC-6 as a representative). AZA:Azacitidine. |
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| S2821 |
RG108RG108是一种DNA methyltransferase抑制剂，无细胞试验中IC50为115 nM，不会引起共价酶的诱捕。 |
The inhibition effect of RG108 on M.SssI MTase activity.
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| S7113 |
ZebularineZebularine是一种DNA methylation抑制剂，与DNA methyltransferases形成共价复合物，也抑制胞苷脱氨酶，无细胞试验中Ki为2 μM。 |
(A) Zebularine treatment suppresses fibre development in vitro. This figure shows that 0 day post anthesis (DPA) ovules cultured for 10 days exhibit different fibre lengths. Different concentrations of zebularine (20, 40 and 80 μM) were applied.
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| S1774 |
ThioguanineThioguanine是一种嘌呤类的抗代谢药物，抑制了DNMT1的活性，广泛用于治疗急性淋巴细胞白血病，自身免疫性疾病（如克罗恩氏病，类风湿关节炎）和器官移植接受患者。 |
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| S7276 |
SGI-1027SGI-1027是一种DNMT抑制剂，作用于DNMT1，DNMT3A和DNMT3B，无细胞试验中IC50分别为6，8和7.5 μM。 |
Following the incubation of the unmethylated DNA probe with DNMTase in the presence of spotted DNMTIs, Cy5 intensity values were measured before ( I0 ) and after ( I30 ) of endonuclease cleavage. Each data set was normalized to the initial fluorescence signal within the corresponding block and the resulting ratio describes the net CpG sites remained uncleaved (盨.D., n = 64). The red line represents the inhibitory threshold determined as two standard deviations below the averaged 'unspotted' ratio. On-chip visualization of the corresponding remaining Cy5 signal is placed on the bottom of each column.
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| S2250 |
(-)-Epigallocatechin Gallate(-)-Epigallocatechin Gallate是从绿茶中分离的一种有效的抗氧化剂Polyphenol flavonoid。抑制telomerase和DNA methyltransferase， 阻滞EGF受体和HER-2受体的激活，抑制脂肪酸合成酶以及谷氨酸脱氢酶的活性。 |
-Epigallocatechin-Gallate-S225001Y0120170210.gif)
-Epigallocatechin-Gallate-S225001Y0120170210.gif)
(a) Huh7 cells were incubated with HCVcc of JFH-1 for 2 h before overlaying with 1% agarose dissolved in culture medium or with AR3A anti-E2 neutralizing antibodies, in the presence of 20 μg/ml SZA. EGCG (50 μM) was introduced as a positive control. At 48 h post-infection, infected cells were quantified by IF. Nuclei were stained with DAPI. (b) Numbers of cells per positive colony were determined in 15 foci.
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| S4294 |
Procainamide HClProcainamide HCl是一种sodium channel的阻断剂，也是DNA甲基转移酶抑制剂，用于心律失常的治疗。 |
