Z-VAD-FMK

目录号:S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。

规格 价格 库存 购买数量  
RMB 962.65 现货
RMB 3841.92 现货
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客户使用该产品的4个实验数据:

  • After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

    (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

  • Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

    Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

产品安全说明书

Caspase抑制剂选择性比较

生物活性

产品描述 Z-VAD-FMK是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。
特性 Z-VAD-FMK是研究细胞凋亡的一种关键化合物。
靶点
Pan-caspase [1]
(THP.1, Jurkat T-cells)
体外研究

Z-VAD-FMK(10 mM)作用于THP.1细胞,抑制细胞凋亡。Z-VAD-FMK(10 μM)作用于THP.1细胞裂解液,抑制PARP蛋白酶活性的激活。Z-VAD-FMK(10 mM)作用于完整THP.1和 Jurkat细胞,抑制CPP32加工。[1]Z-VAD-FMK(50 μM)与Camptothecin共处理HL60细胞,废除Camptothecin处理的细胞凋亡形态。Z-VAD-FMK(50 μM)作用于HL60细胞,抑制Camptothecin诱导的DNA分裂。[2]Z-VAD-FMK (50 μM)作用于S2细胞,提高转染细胞的生存百分数从26%提高到63%。[3]Z-VAD-FMK(>100 μM)作用于人类嗜中性粒细胞,增强TNFα-诱导的中性粒细胞凋亡,较低浓度(1-30 μM)时完全抑制TNFα刺激的细胞凋亡。[4]Z-VAD-FMK (10 mM) 作用于早期角膜基质细胞,抑制细胞凋亡。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a NYfsUGdGSXCxcITvd4l{KEG|c3H5 M1fIflUx|ryP MXeyOIg> MnyzbY5lcWOjdHXzJIEheHKxdHXjeIl3\SCnZn\lZ5Qh[WejaX7zeEBmfG:yb4Pp[IU> NGnjT2ozPjF4OUC3OS=>
HGL5 NYi5OpdGSXCxcITvd4l{KEG|c3H5 NITLZW42OM7:TR?= NXWw[WZZOjSq NFL4b4xqdmSrY3H0[ZMh[SCycn;0[YN1cX[nIHXm[oVkfCCjZ3HpcpN1KGW2b4Dvd4ll\Q>? NVriZpd2OjZzNkmwO|U>
HepG2 MkLQRZBweHSxc3nzJGF{e2G7 NWnjN2JSOjEQvF2= NX7PPZZpOWh? MkP6ZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> MXqyOlE3PDd7NR?=
BEL-7402 NVP1V2NNSXCxcITvd4l{KEG|c3H5 MVOyNO69VQ>? NYO1[lFbOWh? Mmr4ZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> MV2yOlE3PDd7NR?=
CEF NHO4SVVMcW6jc3WgRZN{[Xl? MWKwMFM{NDZ5LEGwNO69VQ>? NHrFd3oyPW2rbh?= NGnLRVRld3ewLYLl[5Vt[XSnczDQVkBmdnq7bXWgZYN1cX[rdImgeI8hPDExvJWgZZQhOTByzszN MWeyOlExOjN|OR?=
SP2/0 MnjTRZBweHSxc3nzJGF{e2G7 M{K4[|ExOM7:TR?= M{LJdVFp Mn6ySG1UVw>? NEfYeYljdG:la4OgeIhmKGGyb4D0c5NqeyCxZjDTVFIwOCClZXzsdy=> NGDFfHozPjB5NEezNi=>
HUVEC-2c MUnBdI9xfG:|aYOgRZN{[Xl? M2nwXVUx|ryP NG[yTFU3cA>? MX;k[YNz\WG|ZXSgeIhmKG:6LVzEUE1qdmS3Y3XkJIF2fG:yaHHnfS=> NY\DXIV3OjZyMkG3Nlk>
U1 NX\6T49DSXCxcITvd4l{KEG|c3H5 MkPsNE0yODEQvF2= MnTONog> MUfy[YR2[2W|IHTyeYcucW6mdXPl[EBieG:ydH;zbZMh[W6mIIP1ZpNmeXWnboSgTGlXNTFicnXwcIlk[XSrb36gbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MWmyOVk5ODl2Mh?=
ACH-2 MWDBdI9xfG:|aYOgRZN{[Xl? NG\rXXcxNTJyMN88US=> NVvQemhNOmh? NEe0eWlz\WS3Y3XzJIRzfWdvaX7keYNm\CCjcH;weI9{cXNiYX7kJJN2[nOncYXlcpQhUEmYLUGgdoVxdGmlYYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MVyyOVk5ODl2Mh?=
U1 MkjGT4lv[XOnIFHzd4F6 NEHjO5gyODEQvF2= M3zpd|Jp MXHpcohq[mm2czDjZZNx[XOnLUO= NEDWeYUzPTl6MEm0Ni=>
A549/V16 Mmr3RZBweHSxc3nzJGF{e2G7 NFHvVYg2OM7:TR?= MljlNYg> NF3LNlRz\XC{ZYPz[ZMhXEdxVF2tbY5lfWOnZDDhdI9xfG:|aYO= M2DKR|I2QTR4MEOz
SGN MWjBdI9xfG:|aYOgRZN{[Xl? NWHkZWE5OjCvTR?= M4jxVFQ5cA>? MUHoZZMhdm9iaX7mcJVmdmOnIH;uJGFKTixiY3HsdIFqdiCneIDy[ZN{cW:wIH;yJINmdGxiYYDvdJRwe2m| NVTBSopWOjV6N{S2N|M>
HCT116  MnrhRZBweHSxc3nzJGF{e2G7 M16yV|Ux|ryP M1jVfFJp M{PB[olvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgSGRXWA>? NFS2fXEzPTh4OEixPC=>
DTK-SME MnjGRZBweHSxc3nzJGF{e2G7 MYe1NO69VQ>? M3rBcVJp M3[yfGROW09? NVTnUJR6eGG{dHnhcIx6KGmwaHnibZR{KHSqZTDhdI9xfG:|aYOgbY5lfWOnZDDifUBjfXCrdnHjZYlv\Q>? MonPNlU5PDN6OUe=
HL-60 MlO0RZBweHSxc3nzJGF{e2G7 Mn3JOVDPxE1? NHnDVpQ1QGh? NV;nWGJHemWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCVS1mtTWkhfHKnYYTt[Y51yqB? MUeyOVgzPDB2Mx?=
U937 MWLBdI9xfG:|aYOgRZN{[Xl? MVu1NO69VQ>? M1[zS|Q5cA>? M2XxdpJm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhW0uLLVnJJJRz\WG2bXXueOKh Moe1NlU5OjRyNEO=
A549 NVXDWpprSXCxcITvd4l{KEG|c3H5 NY\qSY9ZOjBizszN NUi4c2xnOjSq M4r5R5Jm\HWlZYOgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhUE[FUDD0doVifG2nboS= M2PuSVI2Pzl2MUS5
HeLa NV;2dmpISXCxcITvd4l{KEG|c3H5 NVznRYZUOTEQvF2= MlL6OFhp M2TLTIRm[2yrbnXzJJRp\SC{YYTlJI9nKGGyb4D0c5NqeyCmcnHtZZRq[2GubIm= NGLtN3EzPTd5MkW0OS=>
SGC-7901 MkLiRZBweHSxc3nzJGF{e2G7 M2TaZlIxyqEQvF2= NVX3[lVoOWh? MX\pcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IH;4ZYxqeGyjdHnu MUWyOVc3PzB5Nh?=
MCF-7 Mn7mRZBweHSxc3nzJGF{e2G7 Mo\qNVDPxE1? M1fVWVJp MYLpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IEPC NI\Eb5MzPTd{MkGxOC=>
A549 NF7L[lBCeG:ydH;zbZMhSXO|YYm= MVGxNEDPxE1? NUDPZ4l2OjSq MlK3SG1UVw>? MXnwdo9ud3SnczDIRmMufHKnYYTl[EBCPTR7IHPlcIwhe3W{dnn2ZYwhLiCjdITlcpVifGW|IITo[UBkdGWjdnXkJHBCWlBiZYjwdoV{e2mxbh?= Ml\zNlU3QDN3Nki=
U87 NV7GNI9qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHy[Vk2OM7:TR?= NXzHV2R6OWh? MlPhdoVkd3[ncoOgZ4VtdCCpcn;3eIgh\nKxbTDUUXohfHKnYYTt[Y51 MljjNlU3QDF4Nki=
Neocortical Neuron MXHO[ZVzd3SxeHnjbZR6KEG|c3H5 Mn7HNVAx|ryP NEDqOlcycA>? MVLhcpRi\2:waYrld{BJd2mjbXnk[UBCNUmwZIXj[YQhVmW3cn;0c5hq[2m2eR?= NXv1dG03OjV4N{WwNFE>
Primary human placental cytotrophoblasts NVzrWXZYSXCxcITvd4l{KEG|c3H5 NWW5RY5wOzEQvF2= M1q2R|I1cA>? M{O2WmROW09? MknSdoV3\XK|ZYOgeIhmKGmwaHnibZRqd25ib3[gNVHPui2KU1SyJIJ6KHS{aXPsc5NidsLi MnjvNlU3PDJ3OUK=
MM NWLJR5FoSXCxcITvd4l{KEG|c3H5 M3PEcFUx|ryP NXfqfpV3OjCvaX6= M3zaZZBienSueTDpcohq[mm2czDTTGsucW6mdXPl[EAh[2WubDDk[YF1cA>? MXSyOVU{ODB7OB?=
DLD1 MnX4RZBweHSxc3nzJGF{e2G7 MY[yNOKh|ryP MWSxbC=> M3TqcJBienSueTDy[ZZmenOnczDj[YxtKGGyb4D0c5NqeyClYYXz[YQh[nliV2PQNS=> MUWyOVUzPDJ2Nh?=
MDA-MB-231 NUfSPG9QS3m2b4TvfIlkcXS7IFHzd4F6 MY[xNO69VQ>? NXPSOot5OWh? MUHheYdu\W62czDj[YxtKGSnYYToJIFnfGW{IFPIWWEhfHKnYYTt[Y51 NInGcIMzPTV{MUWwNS=>
MKN28 MlzCRZBweHSxc3nzJGF{e2G7 NWC0V4xXOTEQvF2= NH;oXYQ{OG2rbh?= NH\MbG5FVVOR M4r6WYlvcGmkaYTzJHRPTi4QsTDwcJV{KEOKWD3pcoR2[2WmIHHwc5B1d3Orcx?= M3;OcFI2PTF|OU[w
HL-60 NGD2XZpEgXSxdH;4bYNqfHliQYPzZZk> NEfPfYEyODEQvF2= NYr2[4k3OWh? MnKwSG1UVw>? NGW2WIPDqGmvcILveoV{KH[rYXLpcIl1gSCxZjDUR25Cey22cnXheIVlKGOnbHzz MnLrNlU2ODJ7M{K=
AGS MWrBdI9xfG:|aYOgRZN{[Xl? NGntZWoyOM7:TR?= NFLMUncycA>? M4nmWZBz\X[nboTzJIN2emO3bXnuMYlv\HWlZXSgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{NCBvODygZY5lKC17IIDyc5RmcW6| NUPO[nROOjV2OUKyNVQ>
A549  NWSyUVJLSXCxcITvd4l{KEG|c3H5 MYOxNO69VQ>? MW[yOIg> MnnaZoxw[2u|IFTNRXMucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiYX7kJIFxd3C2b4TpZ{Bk\WyuIHTlZZRp M4O2blI2PDN2OUi5
INS-1 MYfBdI9xfG:|aYOgRZN{[Xl? NXS1RYVzPTEQvF2= NWXUc5diPmh? NVjtPGw4TE2VTx?= MYPk[YNz\WG|ZYOgeIhmKHC{b4DvdpRqd25ib3[g[YFzdHliYYDvdJRwfGmlIHPlcIx{yqB? M3PiZ|I2PDNyOEm3
Primary hepatocytes  MoPWRZBweHSxc3nzJGF{e2G7 NXPoRnV1PTEQvF2= MWqxPIg> MlrobY5pcWKrdIOgZZBweHSxc3nzJI9nKGincHH0c4N6fGW|IHnu[JVk\WRiYomgRYN1KERiYX7kJHRPTi4QsR?= NEXweGozPTRyN{WzPC=>
L929-A  NYr0UFhoS3m2b4TvfIlkcXS7IFHzd4F6 NIq4WXozOMLizszN MoL0NlRp M{TLcolvcGmkaYTzJHRPTs7zLXnu[JVk\WRiY3XscEBl\WG2aB?= M4j3W|I2Ozl6NUSw
L929-N NFi3bINEgXSxdH;4bYNqfHliQYPzZZk> M1XKOVIxyqEQvF2= M2OzZVI1cA>? MmrI[Y5p[W6lZYOg[IVifGhidnnhJIF2fG:lcnnu[UBVVkcQsTDwdo9lfWO2aX;u M3vzOlI2Ozl6NUSw
Cytotoxicity Assay M{nMTmNmdGxiVnnhZoltcXS7IFHzd4F6 M1fVdFIx|ryP M4LvWFQ5cA>? MoPYdJJmfmWwdDDNTG1FNWmwZIXj[YQh[2WubDDk[YF1cA>? NY\KfYtoOjV|OUKxNVY>
COS7 Ml;sT4lv[XOnIFHzd4F6 M3TjTFEx|ryP NGfzfY4zPGh? MXjpcoNz\WG|ZYOgZ4F{eGG|ZTCzM|ch[WO2aY\peIlmew>? M13EeVI2Ozh2MEK1
COS7 M4X4cWFxd3C2b4Ppd{BCe3OjeR?= NFjxNZYyOM7:TR?= MmrNOFhp M1eyfpBienSrYXzsfUBxemW4ZX70[YQhTkNzMEGtbY5lfWOnZDDj[YxtKGSnYYTo NHi4SWozPTN6NECyOS=>
A375 M{DPPWFxd3C2b4Ppd{BCe3OjeR?= MWizNO69VQ>? MVKybC=> MlrGdJJmfmWwdIOgeIhmKGS{dXetbY5lfWOnZDDQRXJRKGOuZXH2ZYdm NFzvTHAzPTN5NkGxOS=>
A549 NIDC[IpCeG:ydH;zbZMhSXO|YYm= NHHvU2g2OM7:TR?= MV6yOIg> NIrHZYlz\X[ncoPld{BzcWKxc3;t[UBjcW:pZX7ld4l{KGGwZDDhdI9xfG:|aYOgZ4F2e2WmIHL5JEBEcGmsb37n[IFv MUGyOVM1QTd6MR?=
A549 MY\BdI9xfG:|aYOgRZN{[Xl? MWSyMlUuOjYQvF2= NF[1bFEycA>? M4r5c4Rm[3KnYYPld{B1cGVicH;weYxifGmxbjDv[kBieG:ydH;0bYMh[2WubIOg[IVx\W6mIH;uJINwdmOnboTyZZRqd26| Mn32NlU{PDJ2Mke=
 NBL-W-S  Ml\DRZBweHSxc3nzJGF{e2G7 MXK1NO69VQ>? NHL1fI4ycA>? NIXPRmhnfWyueTDy[ZNkfWW|IHPlcIwhfmmjYnnsbZR6KGGodHXyJGdCVlRvNkGgeJJm[XSvZX70 MX:yOVMzOzJ{Mh?=
Caki-1  NHP0SZBCeG:ydH;zbZMhSXO|YYm= MX20NO69VQ>? MUW0PIg> M1fnUJJm\HWlZYOgeIhmKG63bXLldkBw\iCDbn7lfIlvKFZvcH;zbZRqfmViY3XscJM> M{nxeFI2Ojd7MUmx
769-P NIHZbG1CeG:ydH;zbZMhSXO|YYm= NVT4UlhlPDEQvF2= NUDPb|NWPDiq MULy[YR2[2W|IITo[UBvfW2kZYKgc4YhSW6wZYjpckBXNXCxc3n0bZZmKGOnbHzz MojTNlUzPzlzOUG=
H9c2 MnfrRZBweHSxc3nzJGF{e2G7 NETLWlE2OM7:TR?= M1jjb|Fp NVfETmJScW6qaXLpeJMhTE:[LXnu[JVk\WRiY3HzdIF{\SB|IHHjeIl3[XSrb36gZpV1KG6xdDD0bIUhdG:|czDv[kBk\Wyucx?= MUGyOVI5OzhzOR?=
K562 MkLQRZBweHSxc3nzJGF{e2G7 NF;hbHI2OM7:TR?= NHHT[Jg1cA>? MkXzbY5pcWKrdIOgToFkNUFvaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> NEDzVpMzPTJ2MU[xPS=>
L929 NEHQcIpCeG:ydH;zbZMhSXO|YYm= MWOxNO69VQ>? NIDsZ483cA>? MYHpcoR2[2W|IH7lZ5JweHSxc3nzJJdqfGhiVF7G NHrKNW4zPTF7NU[2NC=>
A549 NXnzTYw2SXCxcITvd4l{KEG|c3H5 NV\2SlBkOTEQvF2= MUmzbC=> M3WyPZJm\HWlZYOgZ4VtdCCjcH;weI9{cXNiY3H1d4VlKGK7IGDRVS=> NGnFRmMzPTF4MU[5PS=>
MCF-7 M2HKe2Fxd3C2b4Ppd{BCe3OjeR?= MX[yNO69VQ>? NUnJfZJGOmh? NX;NZ4xZ\GWlcnXhd4V{KEuGUj3zbXJPSS2rbnT1Z4VlKGGyb4D0c5Nqew>? M3faV|I2OTh{MkSw
OS NGmwc2xCeG:ydH;zbZMhSXO|YYm= MUSyNE81OM7:TR?= NWHncZNOPzKq MojpbY5pcWKrdIOgU3Mh[2WubDD2bYFjcWyrdImgdoVlfWO2aX;uJIJ6KEN4IHPldoFucWSn M33LPFI2OTV{M{m5
HUVECs M17kW2Fxd3C2b4Ppd{BCe3OjeR?= MoX0NVDPxE1? MnruNog> NFG1cGHDqGmwaHnibZR{KGGyb4D0c5NqeyCjbnSg[oFkcWyrdHH0[ZMh[XW2b4DoZYd6KGmwIFTFUnYzNWmwZnXjeIVlKEiXVlXDdy=> NEf6TZYzPTF|OEewNy=>
EA.hy926 NFrvXIhCeG:ydH;zbZMhSXO|YYm= MojONVDPxE1? MX[ybC=> NFPFdY7DqGmwaHnibZR{KGGyb4D0c5NqeyCjbnSg[oFkcWyrdHH0[ZMh[XW2b4DoZYd6KGmwIFTFUnYzNWmwZnXjeIVlKEWDLnj5PVI3 MoLiNlUyOzh5MEO=
Ebs NF[4XFNCeG:ydH;zbZMhSXO|YYm= NHK3SVkyOC1zMEFOwG0> MYSyOIg> NYLKOI1TyqCPTWTTJIdmdmW{YYTpc44hemG2ZTDk[YNz\WG|ZXSgZZMhfGinIHPvcoNmdnS{YYTpc44hd2Ziej3WRWQv\m2tIHnuZ5Jm[XOnZB?= MYiyOVE{PDhzNx?=
Jurkat NWHyU4xwSXCxcITvd4l{KEG|c3H5 NXX3eXNDOjEQvF2= MlH2NlRp M1nW[2ROW09? MYnwZZJ1cWGubImgbY5pcWKrdDDj[YxtKGSnYYToJI9nKEq3cnvheEBk\WyuczDpcoR2[2WmIHL5JFExODV6LV[0JINwdWKrbnXkJJdqfGhiVmDBxsA> NGraOXIzPTF{MEeyNy=>
K562 M{n4OmFxd3C2b4Ppd{BCe3OjeR?= NHW0S|kxNjFvMd88US=> M1\FfVFp NWXCTFBVcW6qaXLpeJMh[2ynYY\h[4Uhd2ZiSGPQPVAhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MnryNlUyOTlzOEi=
IMR-32 MYPBdI9xfG:|aYOgRZN{[Xl? NIO3dZc1OMLizszNxsA> NYXyfVExOmh? Mn3z[IVkemWjc3WgbY4h[XCxcITveIlkKGOnbHzzJINwdXCjcnXkJJRwKFRvMjD0c5hqdg>? M2TtTFI2ODh2N{W1
RPMI 8226 MmjyRZBweHSxc3nzJGF{e2G7 M1PINlExOM7:TR?= MlnRNYg> NIjESZFidG2xc4SgZ49ueGyndHXsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= MoGzNlUxOzd6NUG=
U266  MVnBdI9xfG:|aYOgRZN{[Xl? NEHNcHkyODEQvF2= NYnaVFZLOWh? M3vwWZBienSrYXzsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= NHL1RXUzPTB|N{i1NS=>
H929  NWnOV4pXSXCxcITvd4l{KEG|c3H5 NIDJeGkyODEQvF2= M4HFcVFp M4PNV5BienSrYXzsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= NGP4[lkzPTB|N{i1NS=>
MM.1S  NHTwOINCeG:ydH;zbZMhSXO|YYm= M{LqUVExOM7:TR?= MnTHNYg> MoTn[YZncWOrZX70cJkheHKndnXueJMhe2:{YX\lcoljNWmwZIXj[YQh[2WubDDk[YF1cCClb33ibY5mKHerdHigcoVkem:|dHH0bY4uOQ>? M1PhcVI2ODN5OEWx
C6 NFfxb4pCeG:ydH;zbZMhSXO|YYm= M4TCUlUx|ryP M2nvbFQ5cA>? M1v3b5Bz\X[nboTzJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JINifXOnZDDifUBxemWpbnXuc4xwdmV? MXeyOVAyOzR5OR?=
AGS NFXiTZJCeG:ydH;zbZMhSXO|YYm= MYK1NO69VQ>? NIfkZYgzPGh? MojQZYJwdGm|aIOg{tIudGGyYXPoc45mNWmwZIXj[YQh[2WubDDk[YF1cCCjbnSgbY5pcWKrdHXkJIdzd3e2aB?= M1u2dFI2ODB7Nkm4
HeLa  M1fHdGFxd3C2b4Ppd{BCe3OjeR?= NGTwXHA1OM7:TR?= M2jiUlI1cA>? NHXxd4dqdmirYnn0d{B1cGViaX7jdoVie2WmIHHwc5B1d3OrczDpcoR2[2WmIHL5JJNqWk6IMUKx M3TnflI1QTJ6Nki1
THP-1  MVPBdI9xfG:|aYOgRZN{[Xl? MW[xNO69VQ>? NVXNT3hIOWh? MkPHdoVlfWOnczDhdI9xfG:|aYOgbY5lfWOnZDDifUBCVEFvU1TUxsA> MkTRNlQ6OjN4NUO=
P815  MUTBdI9xfG:|aYOgRZN{[Xl? M3TZ[FExOCEEtV2= MYCxNog> NX7ycnlETE2VTx?= NVrVWYdqcW6qaXLpeJMhfmm{dYOtbY5lfWOnZDDhdI9xfG:|aYO= M1TPclI1QTJ|Mkez
HCT116 M1XwcmFxd3C2b4Ppd{BCe3OjeR?= NIezSWozOM7:TR?= NVvKU3RIOjSq NGL3ZWZi[nKxZ3H0[ZMhd2ZiVGGtbY5lfWOnZDDhdI9xfG:|aR?= MVeyOFg6ODR2OR?=
SW1116  NFT2[ZlCeG:ydH;zbZMhSXO|YYm= MUKxNEDDvU1? NYPJVYFkOWh? M3\ONGROW09? NHXmTYNz\XO2cnHpcpMh[2WubDDhdI9xfG:|aYOgbY5lfWOnZDDifUBo\W[rdHnubYIheGy3czDk[YNqfGGkaX7l MX:yOFg4PDJ6Nh?=
LOVO NVPH[pBFSXCxcITvd4l{KEG|c3H5 MX:xNEDDvU1? MXmxbC=> NFnzWWpFVVOR M{DIT5Jme3S{YXnud{Bk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JIdm\mm2aX7pZkBxdHW|IHTlZ4l1[WKrbnW= MVKyOFg4PDJ6Nh?=
SNU449  M{[y[WFxd3C2b4Ppd{BCe3OjeR?= M3L5WlIx|ryP MUC0PIg> MUnEUXNQ NETMN5dl\WO{ZXHz[ZMhdWmULUS1NU1qdmS3Y3XkJIFxd3C2b4TpZy=> M4TG[FI1QDRzNkO4
Caco-2 MU\BdI9xfG:|aYOgRZN{[Xl? MoXtOFDjiIoQvF2= NHjubIk1cA>? M2nqcpBz\X[nboTzJHNVNTdvaX7keYNm\CCcTz2xJINp[W6pZYOgZY5lKFSHUjDkdo9x MVWyOFgzOjF6Mx?=
macrophage MnvNR4VtdCCYaXHibYxqfHliQYPzZZk> MoXvNE0zODEQvF2= M1vMcVI1cA>? NUjhVY83cW6mdXPld{BVVkZvIHHu[EBTcXB|LXTldIVv\GWwdDDu[YNzd3C2b4Ppd{BqdiCvYXPyc5Bp[Wen NUfEXYNxOjR5OUm1OlU>
AGS  Ml7ORZBweHSxc3nzJGF{e2G7 MYSyNO69VQ>? NHruN|cyOmh? MVPEUXNQ NEmwVGhz\WS3Y3XzJJRp\SCrbnT1Z5Rqd25ib3[gZZBweHSxc3nzJIlvKHKnc4DvcpNmKHSxIITo[UBGfE:DYzDmdoFkfGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M{jRWVI1Pzh7N{Cz
LCC9  M3HPXGNmdGxiVnnhZoltcXS7IFHzd4F6 MoXaNVAx|ryP NGLESJM2\A>? MVricI9kc3NiY3XscEBl\WG2aDDpcoR2[2WmIHL5JINwdWKrbnH0bY9vKExzNzDhcoQh[2iub4LvdZVqdmV? M4HjOlI1Pzh3MkW2
U937  NF60bldv\WO{b4D0c5NqeyCDc4PhfS=> MkLLNVDDqM7:TR?= NYO0WGt[OzEEoH3pci=> M1HWNIlv\HWlZYOgcoVkem:ydH;zbZMh[2:vYnnu[UB4cXSqIGTOSi=> Mlu5NlQ4PzN5NU[=
T cell M2XCPGNmdGxicILvcIln\XKjdHnvckBie3OjeR?= Ml3qNE0yODEQvF2= M{fnOVczcA>? M3HwZmlEPTB;N{Cg{txONCCrbnjpZol1eyCjboTpMWNFOy2rbnT1Z4VlKFRiY3XscEBxem:uaX\ldoF1cW:wIHnuJHBDVUO| MYOyOFc3QDdyNx?=
HeLa  M1LUbWFxd3C2b4Ppd{BCe3OjeR?= NHX4b|c2OM7:TR?= NHrzcGs4Omh? MkTYSG1UVw>? MofUdJJmfmWwdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2:vcH;1coR{yqBz4pETOS=> M1W3cFI1PzV2N{i2
HeLa  M4TqRWFxd3C2b4Ppd{BCe3OjeR?= MoDHNVAx|ryP MnXZNlRp NEnLeYZ{fXCycnXzd4V{KHKjdHWgc4Yh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IH;2[ZJmgHC{ZYPzbY9vKG:oIFe1PXMhd3JiR{exVkBxOTVyZ3z1[YTDqA>? MYCyOFczOjR4OB?=
IEC-6  NEG5bFVCeG:ydH;zbZMhSXO|YYm= NV62dIVwOTEQvF2= NIXKNZMzPGh? MXnwdoV3\W62czDUZ4RCNWmwZIXj[YQh[2G|cHHz[U0{KGOuZXH2ZYdmKGGwZDFOtk1k[XSnbnnuJIRm\3KjZHH0bY9v NGfmTGwzPDdzMUW3NS=>
HCT116 NFXmfVVCeG:ydH;zbZMhSXO|YYm= MYeyNO69VQ>? MmnrNlRp M12yfYlvcGmkaYTzJJRp\SClZXzsJIFxd3C2b4TpZ{BqdmS3Y3XkJIJ6KFmOVEKwOS=> Mni5NlQ4OTN6MUK=
L02 M4X4TWFxd3C2b4Ppd{BCe3OjeR?= NGDWTVAzOM7:TR?= NV\6eYdZOWh? Mme3dJJmfmWwdIOgeIhmKGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhVUWKUB?= MonWNlQ4ODZ2NkG=
A375 MkmzRZBweHSxc3nzJGF{e2G7 NXrlfnpPOjEQvF2= NI\1coozPGh? M4DobJJmfmW{c3XzJIRq[2m2cnnuc45mKEJvaX7keYNm\CCjcH;weI9{cXN? M{G2UFI1Pjl7MUGx
HDPC MlTYRZBweHSxc3nzJGF{e2G7 MXW1NOK2VQ>? NGTXeZkzPGh? NH;VfGhqdmirYnn0d{BPVy2rbnT1Z4VlKGGyb4D0c5Nqew>? MmDiNlQ3OzR3OUO=
A549 M2ni[mFxd3C2b4Ppd{BCe3OjeR?= NIjrfoM2OML3TR?= M1rOZ|Jp NXO3d5I5TE2VTx?= NWLTZo9MeHKndnXueJMhfGinIHj5dI9lcXCub3nkJGRPSSClb370[Y51KHCqYYPlJIlv\HWlZXSgZpkh[2WyaHHsc4Npem:vaX6= M3;CWFI1PTh6MUO1
 BV-2 Mn3ERZBweHSxc3nzJGF{e2G7 NU\qTldGOjEQvF2= MlPWNog> NXzBS5Vie3WycILld5NmeyCXVj3pcoR2[2WmIHPodo9u[XSrbjDlfJRzfXOrb36gZY5lKGSrbHH0bY9vKG:oIITo[UBvfWOuZXHyJIVvfmWub4Dl MW[yOFU2QDFzOB?=
HT-29  MUjBdI9xfG:|aYOgRZN{[Xl? NIDNNZc2OM7:TR?= MX:0PIg> MmnKZoxw[2u|IITo[UBieG:ydH;zbZMhcW6mdXPl[EBjgSCtYXXtdIZmem:u NFm1cHQzPDV2OUG3OS=>
A549 M1L6TWFxd3C2b4Ppd{BCe3OjeR?= NIG1TYw2|ryP MYqyOIg> M{P3fJN2eHC{ZYPz[ZMhPmYEoDjCT|ExODRyKT3pcoR2[2WmIHHwc5B1d3Orc9Mg NFXXfYEzPDV{OUi3NS=>
MIA-PaCa-2 NX\hNJpRSXCxcITvd4l{KEG|c3H5 MmG1NlRp Ml7PZoxw[2u|IHPs[YF3[WenIH;mJINie3Cjc3WtN{BqdmS3Y3XkJIJ6KGKxdHigRU01PDN4NUSgZY5lKHCjY3zpeIF5\Wx? Mnz1NlQ2OTB7OUK=
Caki-1 MWfBdI9xfG:|aYOgRZN{[Xl? NUKxZXJ1OjEQvF2= MXSxbC=> MlLrbY5pcWKrdIOgV2NRNWmwZIXj[YQh[XCxcITvd4l{ NXfjNJRFOjR3MES2PFE>
CLL M4L2NGFxd3C2b4Ppd{BCe3OjeR?= NYrENnZbOjYQvF2= MWKxbC=> NEDlTHdx[XK2aXHscJkh[myxY3vzJG1NVjJ{M{itbY5lfWOnZDDj[YxtKGGyb4D0c5Nqew>? MmK4NlQ1Pjd4M{S=
SGC-7901 MUnBdI9xfG:|aYOgRZN{[Xl? M1\zcFEx|ryP MoHzNlRp Mkj0dJJwdW:2ZYOgeIhmKEOJSVmtbY5pcWKrdHXkJINmdGxiZ4Lve5RpKGmwIGPHR{04QTBzIHPlcIx{ MUGyOFQ2PDR6OB?=
k1735 NHn4UXJCeG:ydH;zbZMhSXO|YYm= NFnncGgzOOLCid88cS=> NFvQd|U1cA>? NV\FOGpPcW6qaXLpeJPDqFOjbH3vcoVtdGFvaX7keYNm\CCjcH;weI9{cXN? M1[xSVI1PDVzMUG2
HaCaT  M4HmdWFxd3C2b4Ppd{BCe3OjeR?= MXGxNFDPxE1? MUOxbC=> NYnQToM2[my3boTzJHVXSi2rbnT1Z4VlKGGyb4D0c5NqeyCrbjDIZWNiXCClZXzsdy=> MWKyOFM2Pjl7Nx?=
podocytes M2rnRWFxd3C2b4Ppd{BCe3OjeR?= NW\udpFuOjByzszN MWe2bC=> NYS2V2dIcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliMzy0MWRITQ>? MnruNlQ{Ozd5N{e=
 KB MUjBdI9xfG:|aYOgRZN{[Xl? MWO1NO69VQ>? MW[yOIg> MlHpbY5pcWKrdIOgUIlkdy2DLXnu[JVk\WRiY3HzdIF{\S1|IHHu[EBRSVKSIHHjeIl3[XSrb36= NYLaPZdnOjR|M{e0PVI>
 HepG2  MnH3RZBweHSxc3nzJGF{e2G7 M{XFO|Ex|ryP MnLSNlRp M{DC[pJm\HWlZYOgeolu\W62aX6gZ4xm[X[jZ3WgZ4F2e2WmIHL5JGxRWw>? M3TBS|I1OzJ3OEG2
fetal rat lung fibroblasts  M{TlXWtqdmG|ZTDBd5NigQ>? NUDvd5hrQDEQvF5CpC=> NHXhXYEycA>? MmTnbY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> MlXhNlQ{OTRzM{W=
PDL fibroblasts NVnHNFFSU2mwYYPlJGF{e2G7 MlO5PFDPxE4EoB?= NYq3[lZEOWh? NUXUbo9VcW6qaXLpeJMhS2G|cHHz[U0{KGGldHn2bZR6yqB? MVGyOFMyPDF|NR?=
MB49 M3TzdmFxd3C2b4Ppd{BCe3OjeR?= M2rYSVIx|ryP M3r4NlFp MmjmdoV3\XK|ZYOgR20ucW6mdXPl[EBk\WyuIHTlZZRp MkX1NlQzQDJ2M{O=
5637 NIPo[3ZCeG:ydH;zbZMhSXO|YYm= NYDtUW9tOjEQvF2= MoLnNYg> MUDy[ZZmenOnczDDUU1qdmS3Y3XkJINmdGxiZHXheIg> MWCyOFI5OjR|Mx?=
A549  M2nUcGFxd3C2b4Ppd{BCe3OjeR?= M4qx[VExOM7:TR?= NIG0NJc1QGh? M1uzNJN2eHC{ZYPz[ZMhfGinIHHwc5B1d3OrczDjZZV{\WRiYomgdIlx\XKrbnZCpC=> NXjvXlhWOjR{N{KyNFE>
MCC-2 MnSxRZBweHSxc3nzJGF{e2G7 NWjVZW9yOjBizszN MWm2bC=> NUfhNlZ7TE2VTx?= MWHicI9kc3NiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5mKGGyb4D0c5NqeyClZXzsJIRm[XSq NX\OfmRWOjR{NkK2OVg>
ADF M1nFc2Fxd3C2b4Ppd{BCe3OjeR?= M1PPOVQx|ryP NVf4[Fh5Pmh? NHvqUINqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> NX7tNZY1OjR{MkiyN|I>
 U373  NWPCRXFZSXCxcITvd4l{KEG|c3H5 NYjOVmFCPDEQvF2= NYjtV2JyPmh? NHrwb3hqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> MoXlNlQzOjh{M{K=
RKO-HIPK2i MWjBdI9xfG:|aYOgRZN{[Xl? MkjiOFDPxE1? MmHYOog> NUjn[G9EcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3jlcY91cGW{YYD5JJBtfXNiWn7DcFI> MYKyOFIzQDJ|Mh?=
HEC-1B NWq4N3FTSXCxcITvd4l{KEG|c3H5 NG\VNW8zOM7:TR?= MkXDNYg> NFTzW2Jz\WS3Y3XzJHRRNWmwZIXj[YQh[XCxcITvd4l{yqClYYPwZZNmNTNiYX7kJINie3Cjc3WtPS=> NHvyWXUzPDJzM{O1PC=>
4T1 M{nSPGNmdGxiVnnhZoltcXS7IFHzd4F6 M37ENFIvPS1zMN88US=> M3zGZ|Rp M1G5Z2ROW09? Mmn3doV{[3WnczD0bIUh[3m2b4TvfIlkcXS7IH;mJFRVOSClZXzsd{BqdmS3Y3XkJIJ6KFOSRGSgbY4h[SClb37j[Y51emG2aX;uJIRmeGWwZHXueEBu[W6wZYK= MXOyOFIxPjF4MR?=
OS  NGjXdIdCeG:ydH;zbZMhSXO|YYm= MVmyNO69VQ>? MknBOIg> M1nVWIlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHPheZNm\CCkeTDQSHQ> NIHPd|QzPDJyNEmzOy=>
RPE Mo\4RZBweHSxc3nzJGF{e2G7 Mo\QNVAx|ryP NV\qW284PDiq MUnwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGOjbIDhbY4uOSCjbnSgMVIh[WO2aY\heIlwdiCjczD3[YxtKGG|IITo[UBk[XOyYYPlJIFkfGm4YYTpc44> MoHSNlQzODJyNUK=
UD29a M2PQeGFxd3C2b4Ppd{BCe3OjeR?= MVu1NO69VQ>? MlPuNlRp MniwbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiY3H1d4VlKGK7IF7VWFM> NWG3N3ZvOjRzOUC1O|Q>
SH-SY5Y  MVLBdI9xfG:|aYOgRZN{[Xl? NVXNbVVzOTEQvF2= NWLIO5FXOjSq M1PQRYF1fGWwdXH0[ZMh[2G|cHHz[UBi[3SrdnH0bY9vKGGwZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhUE6HLULESy=> M3HuUlI1OTR3NE[z
HeLa  M1vNdWFxd3C2b4Ppd{BCe3OjeR?= M3[2e|ExNzJyzszN NWT6Z4xJOjSq NUDjVnBKcW6qaXLpeJMhfGinIHHjeIl3cXS7IH;mJJRp\SCvYXrvdol1gSCxZjD0bIUhdWWvYnXyd{Bw\iC2aHWgZ4F{eGG|ZT3mZY1qdHl? M1TvblI1OTN5Mk[2
SCCVII  MX3BdI9xfG:|aYOgRZN{[Xl? MUmyOe69VQ>? NUSzNJFpOWh? MlnubY5pcWKrdIOgeIhmKGOnbHygb4ltdGmwZzDh[pRmeiCmYYPheIlvcWJ? M{L1T|I1OTJ4NE[0
RAW 264.7 NH\KTWVCeG:ydH;zbZMhSXO|YYm= NF75PJAzOM7:TR?= NGDFblIyQGh? NFv1XpVqdmO{ZXHz[ZMhVEN|LVnJM:6zNWGldHnuJJJifGmxIHPvcZBiemWmIITvJGVEXFZvTV;TJJRz\WG2bXXueEBwdmy7 MYmyOFEyPjdyNx?=
A549  MmrQRZBweHSxc3nzJGF{e2G7 NED5OIozNjYQvF2= M{\CfFI1cA>? MmXI[IVkemWjc3XzJI9zcWSxbnnuMYlv\HWlZXSgZZV1d3CqYXf5JIF{KHenbHygZY5lKEyxc4Ogc4Yh|pURiH2gZYx{dyCxY3P1dpJm\CCmdYLpcoch[XW2b4DoZYdq[yCycn;j[ZN{ NYLscHFvOjRzMEK1NlI>
UM-SCC-10A  MYnBdI9xfG:|aYOgRZN{[Xl? MkLrOVDDvU1? MmntNog> M{HpT5Jm\HWlZYOgZZBweHSxc3nzJIlv\HWlZXSgZpkhcGmpaD3kc5NmKGm|b3HsZY51d2yjY4TvcoU> NHrTeIEzPDB7OEe1Ny=>
BGC-823 MXTBdI9xfG:|aYOgRZN{[Xl? MUixNEDPxE1? MofXNlRp NWO4V2tuemWmdXPld{B1\XS{YX7kdolv\S2rbnT1Z4VlKGGyb4D0c5Nqe8Li M3K0RlI1ODl6NUGx
Nalm-6  NVvaVnkxSXCxcITvd4l{KEG|c3H5 Ml7aNlDPxE1? M2nrflRp NVz4VYlQcW6qaXLpeJMh[2G|cHHz[U05KGGwZDDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiUFHSVE0yKGOuZXH2ZYdm NYXsdWhbOjRyM{m5Olc>
KHOS  MkjFRZBweHSxc3nzJGF{e2G7 NX;ZSWRTPDEQvF2= MVmyOIg> NUHZ[VRy[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> NUL5[29UOjRyMkWzOlE>
G292 Mly2RZBweHSxc3nzJGF{e2G7 M3fxXVQx|ryP NXewSW5ZOjSq MX7icI9kc3NidHjlJIlv[3KnYYPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiaX7keYNm\CCkeTDCRm1FO8Li NWLkW217OjRyMkWzOlE>
MG-63 Mn7hRZBweHSxc3nzJGF{e2G7 M4D1UVQx|ryP MWSyOIg> NX62Zpls[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> MW[yOFAzPTN4MR?=
EBV-transformed B cells MXPBdI9xfG:|aYOgRZN{[Xl? NEWwWIkzOM7:TR?= MYWybC=> MWHEUXNQ NGroNGJjdG:la4OgZY51cS2FREiwJIFv\CCjboTpMWNFQDZiYX70bYJw\HlvaX7keYNm\CCjcH;weI9{cXN? NYrZcXJbOjRyMEi2Nlg>
IM-9 B M17zeWFxd3C2b4Ppd{BCe3OjeR?= MXGyNO69VQ>? M13ifVJp M3voUmROW09? MXficI9kc3NiYX70bU1ETDhyIHHu[EBidnSrLVPEPFYh[W62aXLv[JkucW6mdXPl[EBieG:ydH;zbZM> MXiyOFAxQDZ{OB?=
CNE1 M4PRTmFxd3C2b4Ppd{BCe3OjeR?= NYHSRZlZOjEQvF2= NXLDW4pNPDiq NFjySFdjdG:la4OgUGsuSS2rbnT1Z4VlKGGyb4D0c5Nqew>? MUGyN|k5PTB{OR?=
CNE2 NHHkNpRCeG:ydH;zbZMhSXO|YYm= MUSyNO69VQ>? NX7sR5pyPDiq NHfTRWxjdG:la4OgUGsuSS2rbnT1Z4VlKGGyb4D0c5Nqew>? MX[yN|k5PTB{OR?=
HL-60 MXnBdI9xfG:|aYOgRZN{[Xl? M4\QcFUxyrWP MX:xbC=> MlTHSG1UVw>? NUjUVY5YcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliQlGxOFU> NH62To8zOzl2OEe1NS=>
L929 NICybVZCeG:ydH;zbZMhSXO|YYm= MVuxMlI26oDVNdMg{txOyqB? MlTmNlRp M1vpeIF2\22nboTzJHRPTs7zLXnu[JVk\WRibnXjdo9xfG:|aYOgZY5lKGG3dH;wbIFogQ>? MoHZNlM6PDF5Nkm=
Jurkat NY[yc4N3S2WubDDWbYFjcWyrdImgRZN{[Xl? MX:y{txO MUC0bC=> MXXy[ZZmenOnczDndo94fGhiaX7obYJqfGmxbjDhcoQh|rJvY3H0[Y5qdiCmZXPy[YF{\SCkeTDIV{1CW0F? Mn\sNlM5QTZyNkG=
RAW264.7  M4i1VWFxd3C2b4Ppd{BCe3OjeR?= MnfDNVAh|ryP NVvvW29rOjSq NYTQfmpT\GWlcnXhd4V{KHSqZTDhdI9xfG:|aYOgbY5lfWOnZDDifUBISQ>? M4H5fFI{QDJyMkCz
A431  NHfaXY5McW6jc3WgRZN{[Xl? M1X6[VQx|ryP M1n5WFJp NFnnU29jdG:la4Og[ol{\XSrbj3pcoR2[2WmIHPs[YF3[WenIH;mJINie3Cjc3XzJIFv\CCSQWLQ M3jSUlI{QDByMEW4
Jurkat Mnm3R4VtdCCYaXHibYxqfHliQYPzZZk> MUeyOU0yODEQvF2= MYS2bC=> M{m5WolvcGmkaYTzJJouTkFvQ13LMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MluyNlM6OzN3M{K=
COS-7  M1TaZ2Z2dmO2aX;uJGF{e2G7 MkT0OVDDvU1? NX3FboUzOjSq NEPBdJFi\m[nY4TzJJRp\SCycn;j[ZN{cW6pIH;mJGFVVjG|IIfpeIgheG:ueWGgeJJi[3S| NHjtSWUzOzl|M{KwPC=>
CAL27 MlL1RZBweHSxc3nzJGF{e2G7 NUnXemtIOTBizszN MWKybC=> NVzFR2pCe3WycILld5NmeyCFdYKtUnB{NXKnZIXj[YQhfmmjYnnsbZR6KGK7IIXwJJRwKDlyJR?= NG\zPXIzOzlzN{O5Oi=>
THP-1  MlXLRZBweHSxc3nzJGF{e2G7 NXm4PGp2OTBvNUFOwG0> M2\2b|Jp NUHh[Gg2cW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nlidILpdJRwdGmmZR?= MmnoNlM6ODB{OUm=
K562 M1;zZ2Fxd3C2b4Ppd{BCe3OjeR?= NVHoR|hGOjEQvF2= MVi0PIg> M2LHN4lvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KDRvTWW= MYGyN|g4Pjh{Nh?=
HL-60 NG[wZ2tCeG:ydH;zbZMhSXO|YYm= MXyxNFDPxE1? MUKyOIg> NFjQUYNqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCjYnnleIFv\SCmaYTldpBmdmW|wrC= MUCyN|g3PTd5OB?=
HeLa  MVXBdI9xfG:|aYOgRZN{[Xl? MVKyNO69VQ>? Ml7DNog> MYTpcohq[mm2czDEUW1RKGmwZIXj[YQh[XCxcITvd4l{ NYX1cXNQOjN6NkO5OlY>
U251 NFP6S4hCeG:ydH;zbZMhSXO|YYm= NVLsWGVEOjEQvF2= M{\5bVI1cA>? NHPhW4hqdmirYnn0d{Bk[XO2aXPpckBqdmS3Y3XkJGczN01icHjhd4Uh[XK{ZYP0JIFv\CCjcH;weI9{cXN? NFLTWI8zOzhzNkixOi=>
HL-60 NH7RcXpCeG:ydH;zbZMhSXO|YYm= MUi1NOK2VQ>? M4DVb|Rp NIjN[2JjdG:la4OgeIhmKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzygMVktKGGwZDDQRXJRKGmwZIXj[YQh[nliNoO= MlTXNlM5ODR5ME[=
Ec-109 NFTkSVFCeG:ydH;zbZMhSXO|YYm= M2P4VVExKM7:TR?= M1e5cFQ5cA>? MYTy[ZBz\XO|ZYOgVGUudWWmaXH0[YQhTWNvMUC5JINmdGxiYYDvdJRwe2m| MnewNlM4QDJ4NEG=
RKO NGfMSZpE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M17YdFExKM7:TR?= M2\0O|I1cA>? NU\pPZl[cW6qaXLpeJMhfGinIHTlZ5Jm[XOnIH;mJINmdGxidnnhZoltcXS7IHPheZNm\CCkeTDERWI> NWTleGFyOjN5NUiwOlQ>
T98G M3\vTWNmdGxiVnnhZoltcXS7IFHzd4F6 MUWxMVExOM7:TR?= NUP3TploOjSq NYHIeWVscW2ycn;2[ZMh[2WubDD2bYFjcWyrdImgZ491emWjdH3lcpQhf2m2aDDUVy=> M17jcFI{PzZ7Mke1
Jurkat MUfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MnPSNVAxNTJyMN88US=> M{HyTlI1cA>? NVLMTGd7cW6qaXLpeJMhUGGDNDDpcoR2[2W|IHHwc5B1d3OrczDk[ZBmdmSnboSgc4Yh[2:wY3XueJJifGmxbtMg M4LJZlI{PzN{NEix
Molt-3  MmHwRZBweHSxc3nzJGF{e2G7 NUWxNoY2PTEQvF2= MWOybC=> MnX3doVlfWOnczDt[YxifG:waX6tbY5lfWOnZDDhdI9xfG:|aYO= M2rvWlI{PzJ3MEGz
hMSC12 NID5e2NCeG:ydH;zbZMhSXO|YYm= M16ydVExOM7:TR?= NYixSFlVPGR? NXrwRodwcW6qaXLpeJMhd3O2ZX;n[Y5q[yCldXz0eZJmNWmwZIXj[YQh[2WubDDk[YF1cCCjbnSgZ4Ft[2moaXPheIlwdg>? NX\hbJM3OjN4NUe4NlI>
HM7  NH\YUmZCeG:ydH;zbZMhSXO|YYm= MWWyNO69VcLi M1TzOVFp M1fUeoJtd2OtczDhdIlkfWyjcnXuJGEh[WOndHH0[U1qdmS3Y3XkJINie3Cjc3WtN{Bi[3SrdnH0bY9vKGGwZDDQRXJRKGOuZXH2ZYdm M3mwRlI{PTh|NEGy
Hep-2  M2jXZmFxd3C2b4Ppd{BCe3OjeR?= NUG3eIRDOjEQvF5CpC=> MmHqNlRp MmDoSG1UVw>? NF75ZmJidGyndnnheIV{KHSqZTDk[YNz\WG|ZTDv[kBk\WyuII\pZYJqdGm2eTDpcoR2[2WmIHL5JJNqdGmkaX7pci=> MmTqNlM2QDByM{K=
HSCs M{fZZ2Fxd3C2b4Ppd{BCe3OjeR?= NXjVUYlWPTEQvF2= M4fndFI1cA>? NE\oSpZFVVOR Mof6bY5pcWKrdIOgcoltd3SrbnniMYlv\HWlZXSgSG5CKGSjbXHn[UBqdmSrY3H0[YQh[nliUFHSVEBkdGWjdnHn[S=> NWnXPWhYOjN2OUm4O|Q>
HL-60  M2PB[2N6fG:2b4jpZ4l1gSCDc4PhfS=> MWOyNO69VcLi M2P1RlI1cA>? MnfidoVlfWOnczD0bIUh[3m2b4TvfIlkKGWoZnXjeEBw\iCHcom1 M33KZ|I{PDl2NEiw
HA NXf6eZRLSXCxcITvd4l{KEG|c3H5 MmHiOVDPxE1? NWHqbY1mOjSq NF74[oR{fXCycnXzd4V{KHSqZTDjcIVifmGpZTDv[kBRSVKSIHHu[EBk[XOyYYPlMVMtKC15LDDhcoQhNTliaX7keYNm\CCkeTDic5J1\XqxbXniM3NCUEF? M2ToflI{PDd3OUW2
C666-1 NFTJXXRCeG:ydH;zbZMhSXO|YYm= M33xOFUx|ryP NXnubmU1OjSq M1npdJN2eHC{ZYPz[ZMhfGinIHPs[YF3[WenIH;mJHBCWlBiYX7kJINie3Cjc3WtN{whNTduIHHu[EAuQSCrbnT1Z4VlKGK7IHLvdpRmgm:vaXKvV2FJSQ>? NYD2XlduOjN2N{W5OVY>
Hepa1-6 MVPBdI9xfG:|aYOgRZN{[Xl? M3uxbFUx|ryP NELpfXEzcA>? MVzpcohq[mm2czDjeZJkfW2rbjDhcoQhemW|dnXyZZRzd2xvaX7keYNm\CCjcH;weI9{cXN? Mm\hNlM1PDZ5NUO=
PLC/PRF/5c MVPBdI9xfG:|aYOgRZN{[Xl? MmPJOVDPxE1? MkDGNYg> NXLWT4hVeHKndnXueJMh[XCxcITvd4l{KHS{aXfn[ZJm\CCkeTDDTW4> NX3EcFNVOjN2M{i4NlQ>
HCT116 MY\BdI9xfG:|aYOgRZN{[Xl? NYP0NWxkOTByzszN MYCxMlVp MYfpcohq[mm2czDPd{1qdmS3Y3XkJINmdGxiZHXheIg> M1z1UVI{PzR2M{Wz
HCEC NILBUmVHfW6ldHnvckBCe3OjeR?= Mk\OOVDPxE1? NW\sVXN[PzKq NVPyb|NKTE2VTx?= NIGyc3Bz\XO2b4Lld{Bw\iC2aHWgco9zdWGuIFjDSWMheGinbn;0fZBm MVOyN|c1OjBzMR?=
Primary rat cerebral cortical neurons NF3I[YNCeG:ydH;zbZMhSXO|YYm= MmfzNVAx|ryP M1XHcVFp MmO4dJJmfmWwdIOgR4QucW6mdXPl[EBieG:ydH;zbZMh[W6mIHPlcIwh\GWjdHi= MmDBNlM4PDF|MUe=
MDA-MB-231  NUPhXZBySXCxcITvd4l{KEG|c3H5 MWWyOe69VQ>? M3LPPVI1cA>? NGr2Z4Zi[nKxZ3H0[ZMh[3m2b4TvfIlkcXS7IHHu[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiaX7keYNm\CCkeTDS[|M> NUX4cnNzOjV|M{e1OFQ>
NLRP3-Tet-on-MC/9  MUDBdI9xfG:|aYOgRZN{[Xl? MWexNE01OM7:TR?= NFrmc|QyOmh? MkDtZZR1\W63YYTld{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgR2FRWy2jc4PvZ4lifGWmIF7MVnA{KG23dHHueJMhcW5idHjlJHRmfC2xbjDzfZN1\W1? NHvRR24zOzdyM{O4PS=>
KNS42  MlLrRZBweHSxc3nzJGF{e2G7 MofVOVDPxE1? MkTqNYg> M1vFeJJm\HWlZYOgZ4VtdCCmZXH0bEBidmRiY3;tdIxmfGWueTDhZo9tcXOqZXSgZ4F{eGG|ZTCzM|ch[WO2aY\peJkhcW5icnXzdI9ve2VidH:gRWJVNTJ4Mz:ySGcwdWW2Zn;ycYlvKGOxbXLpcoF1cW:w M{LvU|I{PjlzMUS1
MCF-7  NFPXc4hCeG:ydH;zbZMhSXO|YYm= NITnboMzOM7:TdMg NXjybJB{PzKq MXXpcohq[mm2czDldZVwdC1iYX7kJFQuV0iWLX3l[IlifGWmIHHwc5B1d3Orcx?= M1HlOFI{Pjd3NkSz
hCMEC/D3  NF;me4ZCeG:ydH;zbZMhSXO|YYm= M1TtflI2|ryP NX\MVXRuPzKq MYny[YR2[2W|IFz0fGEhcW6mdXPl[EBieG:ydH;zbZM> MXiyN|Y3PTF7OB?=
Jurkat MWrBdI9xfG:|aYOgRZN{[Xl? MVGxNk42NTVyzszN NF71[JgycA>? MXHkc5NmKGSncHXu[IVvfGy7IIP1dJBz\XO|ZYOgV3BJNWmwZIXj[YQhWGG{LUSgZ4xm[X[jZ3WsJHBCWlBiY3zlZZZi\2VuIFTORUBnemGpbXXueIF1cW:wLDDhcoQhdG:|czDv[kB3cWGkaXzpeJk> MXGyN|Q1Ojl5Nh?=
CNE-1 MWXBdI9xfG:|aYOgRZN{[Xl? NH7HUWMzOM7:TdMg M2T3c|I1cA>? M3Tu[YlvcGmkaYTzJHJCTDByMT3pcoR2[2WmIHPlcIwh\GWjdHi= Mo\vNlM1OjZ6NUC=
HONE-1 M{HuU2Fxd3C2b4Ppd{BCe3OjeR?= MUmyNO69VcLi NFHqPIozPGh? MX;pcohq[mm2czDSRWQxODFvaX7keYNm\CClZXzsJIRm[XSq NELmVHEzOzR{Nki1NC=>
astrocytes cell M3nPeGFxd3C2b4Ppd{BCe3OjeR?= M3HXVlQx|ryP M37pUFZp MkH6doVlfWOnczDlZZJtgSCjcH;weI9{cXNiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5m NF;WVmczOzRzMUe3PC=>
U-937 Ml7HRZBweHSxc3nzJGF{e2G7 MYexNO69VQ>? MX6zNI1qdg>? NXL5SoNneHKndnXueJMhXE6ILXnu[JVk\WRibnXjdo9xfG:|aYO= M1;scFI{PDFyN{S4
MDA-MB-231 MkDORZBweHSxc3nzJGF{e2G7 NWLPfnZyOTByzszN NWf0R5g2OWh? MYHpcohq[mm2czDz[Y5{cXSrenH0bY9vKHSxIGTSRWlNKHWyb36gUXRFUCCmb4fuMZJm\3WuYYTpc44> NXXrNWNLOjN2MEi0Nlk>
HeLa  NGnvZWhCeG:ydH;zbZMhSXO|YYm= M1LubVExOM7:TR?= M13BfVJp NITXZ2pjdG:la4OgTnJUNTF3IFnu[JVk\XNiQYDvdJRwfGmlIFPlcIwhTGWjdHi= NIXvTJMzOzN2NEC0OS=>
Ec109 NHzCUVRCeG:ydH;zbZMhSXO|YYm= NGfxNZcyOM7:TR?= MnXwOog> M2fpXIJtd2OtczDhdI9xfG:2aXOgZ49u[mmwYYTpc44hd2ZiVHH0MXNu[WOQNzDhcoQhemGmaXH0bY9v NUXm[Wg4OjN|M{i1Olg>
H460  MkDnRZBweHSxc3nzJGF{e2G7 MXyxNO69VQ>? NXfBeI9UPmh? NXrPeJNK[myxY3vzJIFxd3C2b4TpZ{Bkd22kaX7heIlwdiCxZjDUZZQuW22jY163JIFv\CC{YXTpZZRqd25? NFnFPWczOzN|OEW2PC=>
HeLa  M3jyUmFxd3C2b4Ppd{BCe3OjeR?= MXO1NO69VQ>? NUnkc4k5OS53aB?= MXzhZpJw\2G2ZYRCpGNpdGGveXTpZU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NUj1eVE1OjN|MEO4NFQ>
SK-HEP1 NXP5foN4SXCxcITvd4l{KEG|c3H5 NIjqW2UyODEQvF2= Mm\vNYg> MlzHbY5pcWKrdIOgR5JVOSCjY4TpeoF1\WRiY3HzdIF{\S1|LDCtO{whNThuID25MEBidmRicH;sfUhCTFBvcnnic5NmMSCyb3z5cYVz[XOn NFO2TXczOzNyMk[1NC=>
QGY7701 MmW4RZBweHSxc3nzJGF{e2G7 Mn\VNlXPxE1? MUSxMlVp NVPUZ5hHcW6qaXLpeJMh[WOldX31cIF1cW:wIH;mJJN2[i2JMTDwbIF{\SCrbnT1Z4VlKGK7IFTPXEAsKHG3ZYLj[ZRqdg>? NHz4U20zOzJ2MEC2NS=>
HepG2 MoWzRZBweHSxc3nzJGF{e2G7 NF;KPWMzOM7:TR?= MoPmN|BucW5? NULpOm9DcW6qaXLpeJMhfGinIHXubIFv[2WmIHPlcIwh\GWjdHigZpkh[2:vYnnu[YQhfHKnYYTt[Y51KG:oIHHwbYdmdmmwIHHu[EBVWkGLTB?= NF\sdJozOzJ{NEKzPS=>
U87  MVLBdI9xfG:|aYOgRZN{[Xl? MU[yOe69VQ>? M4LYVVJp M13GeIRm[3KnYYPld{Bqe2:uaYH1bZJqfGmpZX7pckApUVOOKT3pcoR2[2WmIHHwc5B1d3SrYzDj[YxtKGSnYYToMEBjfXRibn;0JI5m[3KxdHnjJINmdGxiZHXheIg> MXmyN|IzQTZ{Nh?=
HSC-2 NGHvSXhCeG:ydH;zbZMhSXO|YYm= MYGyOU82OM7:TR?= NUfkOVlWOWh? MYXpcohq[mm2czDTUk0{QC2rbnT1Z4VlKGO7dH;0c5hq[2m2eR?= NYTZU|FsOjNzNUWyOFg>
HSC-4 MWXBdI9xfG:|aYOgRZN{[Xl? NIDLUWEzPS93MN88US=> M{HseVFp MlXtbY5pcWKrdIOgV24uOzhvaX7keYNm\CCleYTveI95cWOrdIm= NYjWOo57OjNzNUWyOFg>
CL-1 M1L4bGFxd3C2b4Ppd{BCe3OjeR?= NITBOlczOM7:TR?= MYqxbC=> MXjicI9kc3NiT2C0OFkhcW6mdXPl[EBk\WyuIHTlZZRp NYDJXXlpOjNzM{G3PFI>
MEL NG[4N5RCeG:ydH;zbZMhSXO|YYm= M4PrXFIx|ryP M2Hme|I1cA>? NYnNVXRmTE2VTx?= MmS2bY1x[Wm{ZYOgVFJZPy2rbnT1Z4VlKE2HTDDj[YxtKGGyb4D0c5Nqew>? NVW2WIt5OjNyMUS4PFc>
Bel-7402  Mo\1R4F{eGG|ZTDBZ5RqfmG2aX;uJGF{e2G7 NIK0OHk2OM7:TR?= NWP3TWpvOmh? M2rOdYlvcGmkaYTzJHBETS2rbnT1Z4VlKGGwb3nrbZM> MYeyN|AxQDd2Mh?=
Eca-109 MUfBdI9xfG:|aYOgRZN{[Xl? Mlr6NlXPxE1? Ml7YN|BucW5? M1fIU4lvcGmkaYTzJGJLNUJzMT3pcoR2[2WmIHPlcIwh\GWjdHi= M2DFVVI{ODd4OU[3
MEL MnPXRZBweHSxc3nzJGF{e2G7 M3;rVFIx|ryP NF\4c|UycA>? MWLEUXNQ MVvpcZBicXKnczDQNng4NWmwZIXj[YQhVUWOIHPlcIwh[XCxcITvd4l{ M2jWeFI{ODF2OEi3
Bel-7402  NWDVOHpmSXCxcITvd4l{KEG|c3H5 NWHGZpUyPTEQvF2= NHnIXmIzcA>? Mlz1bY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> NYfSTFBZOjNyMEi3OFI>
L929 Mo\ZSpVv[3Srb36gRZN{[Xl? MWqyMlXPxE1? NIniS4kycA>? NX;PbYxYcW6lcnXhd4V{KFKLUEGg[ZhxemW|c3nvckBidmRiZYjhZ4Vz[mG2ZXSgWG5H|rFvaX7keYNm\CCvaYTvZ4hwdmS{aXHsJIR6e2[3bnP0bY9vKGGwZDDSU3MheHKxZIXjeIlwdg>? NGfXOXgzOzByMEWxPC=>
RCC  M2DnRWNmdGxiVnnhZoltcXS7IFHzd4F6 M173W|ExOM7:TR?= MlrqNlRp M4TGT5Jm[2:4ZYLld{B1cGVidnnhZoltcXS7IH;mJINmdGy|IHX4dI9{\WRidH:gNVVlNVCJSkK= NGHkWWgzOjl7MUS5OC=>
NB2a/d1 NUS4eIxYSXCxcITvd4l{KEG|c3H5 MXqxNFDPxE1? MWC3Nog> NHXwR4tifHSnboXheIV{KHO2YYXyc5Nxd3KrbnWtbY5lfWOnZDDjZZNx[XOnIHHjeIl3cXS7LDDQRXJRNCCjbnSgeIF2KGOuZXH2ZYdm MkjFNlI6QDh3NEG=
T cell Mo\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPWRYJ4OjVvMUCw{txO NXjhR4FbOjSq NYrr[2Rr\G:|ZT3k[ZBmdmSnboTsfUBqdmirYnn0[YQhXCClZXzsJJBzd2yrZnXyZZRqd25ibXXkbYF1\WRidHjyc5VocCC2aHWgZ48ue3SrbYXsZZRqd25id3n0bEBidnSrLVPEN{BidmRiYX70bU1ETDJ6 MYWyNlk5OjV|OB?=
K562 NEf1NY5CeG:ydH;zbZMhSXO|YYm= MofYNVAx|ryP M2T2[FFp MnnIZoxw[2u|IFHico9j[X[rc3P1ceKhTi2rbnT1Z4VlKGGyb4D0c5Nqew>? NV:4eFRtOjJ7N{KzO|I>
Jurkat  M3L3SGFxd3C2b4Ppd{BCe3OjeR?= MnrEOFDPxE1? NVvKXVFYOWh? MXjhZo9tcXOqZYOgSoF{VC2rbnT1Z4VlKGOjc4Dhd4Uh[WO2aY\heIlwdiCjbnSgZ4VtdCCmZXH0bC=> MYSyNlk1Ojd|OB?=
BGC-823 M2H6VWFxd3C2b4Ppd{BCe3OjeR?= NXjjN2xyOTByzszN MonLNYg> M4\ZZ5BienSrYXzsfUBz\XOldXXzJINmdGy|IHHnZYlve3RiZHHtZYdmKG:oIHThbYR7\Wmw NFvpemMzOjl{NkW0OS=>
Hep3B MXfBdI9xfG:|aYOgRZN{[Xl? M4W4WVUx|ryP MYmxbC=> NHjTOVVjdG:la4OgZZBweHSxc3nzJIlv\HWlZXSgZpkhUEWJQ4O= MkLkNlI6OjNzNUS=
LLC-PK1 M1S5U2Fxd3C2b4Ppd{BCe3OjeR?= MmfINlDPxE1? MXuxbC=> NXi1WmpzeHKndnXueJMh[2m|cHzheIlvNWmwZIXj[YQh\GWpcnHkZZRqd25ib3[gRZRoPSxiYnXjcIlvNTFuIHHu[EBCfGdzMjDwdo91\Wmwcx?= NXX5[HdrOjJ6OU[wN|c>
A549 MXvBdI9xfG:|aYOgRZN{[Xl? M13VPFUx|ryP M4XNPFFp MWLicI9kc3NidHjlJGJCUS2rbnT1Z4VlKGGyb4D0c5Nqe8Li NXjacZI1OjJ6OEeyNVU>
SGC-7901  NI\4SFhCeG:ydH;zbZMhSXO|YYm= MnzkNVDPxE1? NXzwbFQ2OjSq MX\pcohq[mm2czFOtkzPui2maX3leIh6dGGlconsd4hqc2:waX6tbY5lfWOnZDDhdI9xfG:|aYRCpC=> MYOyNlg1QDV7Nx?=
DM6 M3LJU2Fxd3C2b4Ppd{BCe3OjeR?= NELv[2oyODEQvF2= NHXpbm44Omh? MnLnZoxw[2u|IHLveIghTTKILUGgZY5lKEV{RoTyMY1m\GmjdHXkJIN6fG:2b4jpZ4l1gQ>? MUCyNlgzPTN{OB?=
MCF-7, MDA-MB-468, Caco-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nHcFUx|ryP MlLaOFhp NXXqfJNmcW6qaXLpeJMhfGinIHPlcIwh\3Kxd4ToJIlvcGmkaYTpc44hcW6mdXPl[EBjgSC|YYDvcolv NVjaVZB2OjJ6MEC5Olg>
A2750  NFnJdmdCeG:ydH;zbZMhSXO|YYm= MofGNlDPxE1? NULxeWJwOmh? NESwNZNFVVOR NFj3SGNjdG:la4OgZ4F{eGG|ZTDjcIVifmGpZTDkeZJqdmdiaHXs[Y5idGmwIITy[YF1dWWwdDDhcoQhemWmdXPld{BifXSxcHjh[4lkKGOnbHyg[IVifGh? NID4XIIzOjd6NEO2Ny=>
U87  M4foS2Fxd3C2b4Ppd{BCe3OjeR?= NEn0VGMzOM7:TR?= M2nJWVI1cA>? M{nWe5Jm\HWlZYOgeIhmKGGyb4D0c5NqeyC{YYTlJIlv\HWlZXSgZpkhWEyDQh?= Mn:4NlI4Pzh5OEC=
HT1080 M3vxe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDaTJY2OM7:TR?= MWW3[C=> M1vFOIlvcGmkaYTzJJRp\SClZXzsJIdzd3e2aDDpcohq[mm2aX;uJINifXOnZDDifUBkd22kaX7l[EB1emWjdH3lcpQhd2ZiRFPBJIFv\CCRTWC= NGPEO2kzOjd2MEm4OC=>
A549  MUjBdI9xfG:|aYOgRZN{[Xl? Moe3OVDPxE1? NIOxUpgzcA>? NYrVfpE3eGG{dHnhcIx6KGSnY4LlZZNmeyC|b3TpeY0he2WuZX7peIUucW6mdXPl[EBieG:ydH;zbZM> NVHIRoVvOjJ5MkG4NFQ>
Primary OPC MnvtRZBweHSxc3nzJGF{e2G7 NXjETZo1Oc7:TR?= MoC3OogwOjSq MmTqdoVlfWOnczD0bIUheGW{Y3XueIFo\SCxZjDj[YxteyCrbjDlZZJtgS1iYX7kJIxifGVvYYDvdJRwe2m|L37lZ5Jwe2m| Mlf0NlI4ODd|OEW=
PMNs M3;SXGFxd3C2b4Ppd{BCe3OjeR?= Ml7IOFDPxE1? M2H4dVZp NInMdlNFVVOR MkXIdoV3\XK|ZXSgeIhmKGGvb4XueEBw\iClbHXheoVlKGOjc4Dhd4UuOyC2bzDu[YFzKH[naHnjcIUhdGW4ZXzz M4q3[VIzPjl{NUe3
A549  NHG2b2ZCeG:ydH;zbZMhSXO|YYm= NHr6W5U2OM7:TR?= MUWxbC=> M1[3b5Bz\X[nboTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEKjb3j1c5Nq\GViSR?= NX;OWWJiOjJ4OEe2N|U>
AGS NU[2[G9DSXCxcITvd4l{KEG|c3H5 NVPYWVQxOjEQvF2= MVGxNog> MW\pcohq[mm2czD0bIUh[WO2aY\heIlwdiCxZjDwdo8u[2G|cHHz[U0{KGmwIILld5BwdnOnIITvJJRp\SCHdF;BZ{BnemGldHnvci=> NHezc24zOjZ6N{O5PC=>
shC9  MnXERZBweHSxc3nzJGF{e2G7 MUWxNO69VQ>? MoTRNVZp MXPicJVvfHNiU1jIJIV5eHKnc4Ppc44hcW5ic3jDPUBk\WyuczDlfJBwe2WmIITvJIVqfGincjDQRUBweiCOUFO= M1\YOlIzPjRzMEm0
primary MEFs NGi4TIxHfW6ldHnvckBCe3OjeR?= M3OyVFEzcA>? M{TLPeKhcW6lcnXhd4V{KGW2b4Dvd4ll\S2rbnT1Z4VlKG2rdH;jbI9v\HKrYXygcYVu[nKjbnWg[IVxd2yjcnn6ZZRqd25? MmfLNlI3OTN5Nke=
3T9 MEFs NU\KS5k4TnWwY4Tpc44hSXO|YYm= MlO2NVZp M2n5WYlv[3KnYYPld{BkgXSxY3jyc41mKGNicnXs[YF{\SCjZoTldkBmfG:yb4Pp[IUufHKnYYTt[Y51 MWiyNlYyOzd4Nx?=
3T9 MEFs M3\qbWZ2dmO2aX;uJGF{e2G7 NEmxNGgyQGh? M{jkSZVxemWpdXzheIV{KGmwaYTpZZRweiClYYPwZZNmNTliYoX0JIRwf26{ZXf1cIF1\XNiZX\m[YN1d3JiY3HzdIF{\XNiYX\0[ZIh\XSxcH;zbYRmKHS{ZXH0cYVvfA>? MWGyNlYyOzd4Nx?=
MDA-MB-231  NFX0bJlCeG:ydH;zbZMhSXO|YYm= M3TV[VIx|ryP MUK0[C=> M3T0eJJm\HWlZYOgeIhmKGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhdWW2Zn;ycYlvKHS{ZXH0cYVvfCC5YYOgd4lodmmoaXPhcpRtgQ>? M1HFclIzPTl|NESx
C6  MXHBdI9xfG:|aYOgRZN{[Xl? NVq5boZWOTEQvF2= M{GzZlI1cA>? NVHmWmd[[myxY3vzJJRp\SC|dYDwdoV{e2m4ZTDl[oZm[3Rib3[geIhmKHCncITp[IUhd25idnnhZoltcXS7 MoG5NlI2QDh7OEC=
HL-60  M2TWOWFxd3C2b4Ppd{BCe3OjeR?= NF;iPIgyODEQvF2= M{L5NVI1cA>? NETYfXNqdmirYnn0d{B1cGViY3XscEBieG:ydH;zbZMhe2WuZXP0[YQhMCtrLX3lcpRpgWxizsKtLFHjjpJ4KT3kbYdtfWOxcInyZY5we2mmZdMgOS=> MofHNlI2PDZ4Nkm=
HL-60 M17jNWFxd3C2b4Ppd{BCe3OjeR?= MYixNE05OM7:TR?= MoraOIg> NHXVXFdqdmirYnn0d{BVT0iTLXnu[JVk\WRiY3XscEBieG:ydH;zbZPDqA>? NX:0TmtqOjJ3MkOyNlk>
BCC NYfKRYlYSXCxcITvd4l{KEG|c3H5 NI\RRWY2OM7:TR?= Mn3aNYg> M3;nV4lvcGmkaYTzJGRCXFNvbXXkbYF1\WRiZ4Lve5RpKGmwaHnibZRqd25? MmXsNlI2OTl2M{[=
RAW 264.7 NEDEd5RCeG:ydH;zbZMhSXO|YYm= NXPm[|dUPTBxMUCw{txO NVLkbW5wOWh? NW\DVHAx[2:wY3XueJJifGmxbj3k[ZBmdmSnboSgbY5pcWKrdIOgSG9PNWmwZIXj[YQhelKQQTDjcIVifmGpZR?= MkjYNlI1QTF2Mk[=
K562 NUDRXmxkSXCxcITvd4l{KEG|c3H5 NGnJU3AzPc7:TR?= M3rGWVJp NWK4TmF3eHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliY3:teJJm[XSvZX70JJdqfGhiYX31doVve2mwIFegZY5lKFSUQVnM M1TuNFIzPDh|N{e3
SGC-7901 NFTJbJRCeG:ydH;zbZMhSXO|YYm= Mn3zNlAh|ryPwrC= MUSybC=> MVHheJRmdnWjdHXzJGgzVzMEoH;yJHRPTiEQsT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{KGG|IIflcIwh[XNiY3HzdIF{\S1|IHHjeIl3cXS7wrC= NXvyV4Q{OjJ2N{G1PFk>
PC3 M3PEdmFxd3C2b4Ppd{BCe3OjeR?= MkG5NVDPxE1? NIfkOWQ1cA>? NVrm[I1K[2:3boTldpMh\myjdn;jc5hq\C2rbnT1Z4VlKGOjc4Dhd4UuemWuYYTl[EBieG:ydH;zbZM> M33QUVIzPDdzOUe0
SMMC-7721 NXvzcJN3SXCxcITvd4l{KEG|c3H5 NYHtcoRqPTEQvF2= MofZOFhp NVvtTVdP[XS2ZX71ZZRmeyCxVGKtbY5lfWOnZDDhdI9xfG:|aYO= MYKyNlQ3PTh|Mx?=
HeLa  NH\EUYtCeG:ydH;zbZMhSXO|YYm= MV61NOKh|ryP NFXTR3c1Nziq M1vQS4lvcGmkaYTzJHNVWy2rbnT1Z4VlKGyjdHWtdIhie2ViYYDvdJRwfGmlIHX2[Y51ew>? Ml;PNlI1PjB3MES=
HeLa  NVe0XnV6SXCxcITvd4l{KEG|c3H5 M1XaOFUxyqEQvF2= NXLnOFVxOWh? NY\iSpo3e3WycILld5NmeyC2aHWgSnJCWC2rbnT1Z4VlKGGlY4XteYxifGmxbjDv[kBidm6neHnuJHYheG:|aYTpeoUh[2WubIO= MXOyNlQ1QTR2MB?=
T47D  NHHSVpJCeG:ydH;zbZMhSXO|YYm= NXvpcWpwOTByzszN MXOxbC=> NES5[WtjdG:la4OgeIhmKGenbnXyZZRqd25ib3[gSU1k[WRxQ2TGNkBjgSCVVGO= NX;Ed3hmOjJ2MEGxOlg>
HeLa  MWTBdI9xfG:|aYOgRZN{[Xl? M2rT[VMx|ryP MVu0bC=> NH2yTZDDqGmwY4LlZZNmeyC2aHWg[4Vv\XKjbDDj[YxtKH[rYXLpcIl1gSB2ODDoJIFnfGW{IIDoc5Rw\HmwYX3pZ{B1emWjdH3lcpTDqA>? NH7QOYszOjN7NEK0PC=>
HCC MoDlRZBweHSxc3nzJGF{e2G7 NGOwS4QzOCEQvF5CpC=> NV[2SWRLOmh? M{HiSIF1fGWwdXH0[ZMhfGinIFTIRUBqdmS3Y3XkJIFkfGm4YYTpc44hd2ZiUFHSVC=> M{TVTlIzOzR{N{Oy
mESCs NV7DO3l1SXCxcITvd4l{KEG|c3H5 NIDSW5IzNjYQvF2= MoPlNog> MWXpcohq[mm2czD0bIUhVmGILX3l[IlifGWmIHPhd5Bie2ViYXP0bZZifGmxbh?= M{S4c|IzOjh3Mke0
EMT-6  NFvycZREgXSxdH;4bYNqfHliQYPzZZk> MknWNVAx|ryP MUOxbC=> MWfwZZJ1cWGubImgZoxw[2unZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhe2m{YX3ld4lv\Q>? MV2yNlI2OTl{MR?=
MCF7 MVPBdI9xfG:|aYOgRZN{[Xl? NFHKW4Y2OMLizszN NWfnXG9LOWh? M2LDdolvcGmkaYTzJHBCKGGldHn2ZZRm\CClYYPwZZNmNTNuID25MEBidmRicH;sfUhCTFBvcnnic5NmMSCyb3z5cYVz[XOn NWPsW2g4OjJ{MkOzOFU>
K562 MYfBdI9xfG:|aYOgRZN{[Xl? NIfuc4kzOCEQvF5CpC=> MYG0PIg> M1LLRWROW09? NUGyUZZ5[myxY3vzJIxieGG2aX7pZk1qdmS3Y3XkJIlvcGmkaYTpc44hd2ZidnnhZoltcXS7IHHu[EBieG:ydH;zbZMhcW6mdXP0bY9v M1ntWFIzOjF4MUW4
Molt4-hyg MXnBdI9xfG:|aYOgRZN{[Xl? NWPNPVZCOTEQvF2= NYLrbmdjOC53aB?= NWn1T485[myxY3vzJIZiem6nc3;sMYlv\HWlZXSgZ4F{eGG|ZT2zMYxqc2ViYXP0bZZqfHl? NGriOIozPjJ5NUixNS=>
HeLa NY\yPYtxSXCxcITvd4l{KEG|c3H5 NFG4eI8yOM7:TR?= MVuwMlVp MmPQbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhfGinIHPvcYJqdmWmIITy[YF1dWWwdDD3bZRpKGexbXnzbY4hViCjbnSgWHJCUUx? NXvjXHdjOjJzN{m2OlE>
Jurkat T MYHBdI9xfG:|aYOgRZN{[Xl? MoT5N|DPxE1? NYfqVIk3OC53aB?= NI\JWXpFVVOR MVzicI9kc3NidHjlJJpqemGvLXnu[JVk\WRiYYDvdJRwe2m| MlXGNlIyPTl6OUi=
Neutrophil MoX3RZBweHSxc3nzJGF{e2G7 NHnMXW4zOM7:TR?= M3\vV|AvPWh? NVPrWm15[XS2ZX71ZZRmeyC2aHWgdJJwNWGyb4D0c5Rq[yCnZn\lZ5Qhd2ZiTXHSNS=> MXWyOlE6Pjh2NB?=
HCT116 NXLmZ3JkSXCxcITvd4l{KEG|c3H5 NELUb3U2OMLizszN M1y0VFJp Ml7SdoV3\XK|ZYOgd5lv\XKpaYP0bYMh[XCxcITvd4l{KGWoZnXjeJMhd2ZiY3Xs[YNwgGmkIHHu[EBPWENvMUdCpC=> NUDIc29{OjJzNUm3OVI>
MDA-MB-231  NXW0T2N6SXCxcITvd4l{KEG|c3H5 MV:yMlUuPy53zszN MnXiNog> M3zyeolvcGmkaYTzJJRp\SClZXzsJIRm[XSqIH;mJG1FSS2PQj2yN|Eh[2WubIOgbY5lfWOnZDDifUBUTFRiaX6gZUBkd26lZX70doF1cW:wIHTldIVv\GWwdDDtZY5v\XJ? Mnr0NlIyOTV3Mk[=
LNCaP NXqxe|BHSXCxcITvd4l{KEG|c3H5 NIPucmQ1OM7:TR?= MnX0Nog> MnHFbY5pcWKrdIOgZpV1\WmwIHnu[JVk\WRiY3XscEBieG:ydH;zbZM> M3fsZ|IzOTF2N{[0
MB231 NWXZcW1ESXCxcITvd4l{KEG|c3H5 NHLVZmUyODEQvF2= MmrqNYg> MoTPSG1UVw>? MWnhZpJw\2G2ZYOgeIhmKGmwZIXjeIlwdiCxZjDj[YxtKGSnYYToJIJ6KFeHRUGgbY5pcWKrdHnvckwhXFKDSVygeJJm[XSvZX70MEBidmRidHjlJINwdWKrbnH0bY9v M321R|IzOTF{OUSw
HCC38  NEXKb2VCeG:ydH;zbZMhSXO|YYm= NF2zbYoyODEQvF2= NEnLUIUycA>? NUHB[ZZjTE2VTx?= NEG4dIZi[nKxZ3H0[ZMhfGinIHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGK7IGfFSVEhcW6qaXLpeIlwdixiVGLBTWwhfHKnYYTt[Y51NCCjbnSgeIhmKGOxbXLpcoF1cW:w NX3SUIdvOjJzMUK5OFA>
MDA-MB231 MV\BdI9xfG:|aYOgRZN{[Xl? MVS1NOKh|ryP M3PWdlI1cA>? M{\MWWROW09? MUDhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo NXHoZol2OjJzMEGzN|U>
LNCaP MVfBdI9xfG:|aYOgRZN{[Xl? MmPhOVDDqM7:TR?= MX[yOIg> M1HHXmROW09? MXThZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo NYrCem1EOjJzMEGzN|U>
HCT116 MYrBdI9xfG:|aYOgRZN{[Xl? NXrLNnBsPTEEoN88US=> NIqze4wzPGh? NFnwTGlFVVOR NG\pW2Zi[nKxZ3H0[ZMh[3W{Y4XtbY4ucW6mdXPl[EBk\WyuIHTlZZRp NHS5ZYczOjFyMUOzOS=>
Ishikawa  MkjWRZBweHSxc3nzJGF{e2G7 M{jXTVI2|ryP MUOyOIg> NGHySIZz\WS3Y3XzJINmdGxiZHXheIgh[W6mIHHwc5B1d3OrczDpcoR2[2WmIHL5JGJi\iCDMR?= NW\LfI1UOjJyOEi5NVg>
 YD-8  NWTW[4ZJSXCxcITvd4l{KEG|c3H5 M3vqdFExOM7:TR?= Mmf6NYg> MX7pcohq[mm2czDQUGVQNWmwZIXj[YQh[XCxcITvd4l{ NVLYS25YOjJyOE[xPFM>
eosinophil  MkfSRZBweHSxc3nzJGF{e2G7 Mk\6PVDPxE1? M2\NXlI1cA>? MYTpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBH[XNiYX70bYJw\HoEoB?= MWGyNlA4QTN|NB?=
L929 Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIP6U2EzNjYQvF2= NETqTnczPGh? MVzpcohq[mm2czD0bIUh\XiycnXzd4lwdiCxZjDwMZA{QCCjbnSgUmYu|rqEIITvJIF2\22nboSgWG5H|rFvaX7keYNm\CCwZXPyc5B1d3OrczDhcoQh[XW2b4DoZYd6 NWnydmlMOjJyMkewPVc>
YD-8  NGLEOFBCeG:ydH;zbZMhSXO|YYm= M{j2S|ExOM7:TR?= NFK5cJIycA>? NEXpfY9jdG:la4OgeIhmKEeVLVjDcE1qdmS3Y3XkJIFxd3C2b4Ppdy=> NUK3SZNROjJyMkCwO|g>
HBx M{DCUGFxd3C2b4Ppd{BCe3OjeR?= M3nJS|I2|ryP MUS0PIg> MVrEUXNQ M{jPSpJm\HWlZXSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KDNvTVG= NX\xdXBTOjJyMkCwO|g>
U937  NH;WV5pCeG:ydH;zbZMhSXO|YYm= NWnWSItwPTEEoN88US=> MVGxbC=> NXrNcoxXcW6qaXLpeJMhUEZvaX7keYNm\CCjcH;weI9{cXQEoB?= MX:yNVk6QDd|MR?=
HL60 M3z1WWFxd3C2b4Ppd{BCe3OjeR?= MXS0NO69VQ>? NHvTcng1OG2rbh?= NFiwcJNFVVOR MYXicI9kc3NiQl7ER{Bkd22yb4Xu[JMhcW6mdXPlJIV5eG:|dYLlJI9nKHCqb4PwbIF1cWS7bIPldolv\SCjbnSgSG5CKG[{YXft[Y51[XSrb36= NVroSnNDOjF7OEOyPVY>
M-14 NXTNe5JoSXCxcITvd4l{KEG|c3H5 M1\4NlI2|ryP M3XqN|AvPWh? NYizNlRkyqCrbnjpZol1eyCkb4ToJJRp\SClcoXk[UBmgHS{YXP0MUBidmRiY3;tdI92dmRvaX7keYNm\CCjcH;weI9{cXN? MkjVNlE6PTR7NUm=
SK-BR-3 MVTBdI9xfG:|aYOgRZN{[Xl? MWO1NOKh|ryP MYGybC=> MlrKZoxw[2u|IHHwc5B1d3SrYzDEUmEh\nKjZ33lcpRifGmxbjDpcoR2[2WmIHL5JINwdWKrbnH0bY9vKG:oIGPNMVE3PCCjbnSgdoFlcWG2aX;u NXPkbldOOjF7MEGzPFY>
MDA-MB-468 NUKydWJzSXCxcITvd4l{KEG|c3H5 MmT6OVDDqM7:TR?= M3zlZVJp M2TscIJtd2OtczDhdI9xfG:2aXOgSG5CKG[{YXft[Y51[XSrb36gbY5lfWOnZDDifUBkd22kaX7heIlwdiCxZjDTUU0yPjRiYX7kJJJi\GmjdHnvci=> NIfWZWIzOTlyMUO4Oi=>

... Click to View More Cell Line Experimental Data

体内研究 有研究表明,体内Z-VAD-FMK的给药不具有毒性,在动物模型中可抑制凋亡。在小鼠中,腹腔注射HK-GBS可引起早产,而预处理以Z-VAD-FMK可延迟早产现象。在OVA-sensitized的小鼠中,z-VAD-fmk的处理可抑制过敏原诱导的白细胞浸润。在OVA致敏前全身性注射z-VAD-fmk可减少OVA-sensitized/challenged小鼠中炎性细胞的积累、黏液的高分泌以及Th2细胞因子的释放。处理以z-VAD-fmk可阻止晶状体上皮细胞、角质细胞的终末分化;单核细胞向巨噬细胞的分化;以及红系造血祖细胞的分化。z-VAD-fmk可减缓过敏原诱导的呼吸道炎症以及高敏性、阻止后续T细胞的激活[7]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[6]

+ 展开
  • Cell lines: 颗粒细胞GC1a, HGL5, COV434
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    为了确定Z-VAD-FMK的效力,在常氧条件下,用etoposide (50 μg/ml) 和/或 Z-VAD-FMK (50 μM)对三种人源颗粒细胞系(GC1a, HGL5, COV434)进行处理,处理48小时。为了模拟卵巢片段抑制后的缺氧状态,用低氧(1% O2)状态下,用无血清培养基培养细胞,处理以Z-VAD-FMK。用WST-1试验检测细胞的代谢活性。通过FACS检测细胞活力,RT-qPCR和WB检测凋亡相关分子的表达。


    (Only for Reference)
动物实验:

[7]

+ 展开
  • Animal Models: CD1小鼠
  • Formulation: 溶解于DMSO,用PBS进行稀释,最终DMSO浓度小于1%
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

溶解度 (25°C)

化学数据

分子量 467.49
化学式

C22H30FN3O7

CAS号 187389-52-2
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Can you suggest an in vivo formulation of S7023 for animal studies?

  • 回答:

    For in vivo study of S7023, The IP formulation is 2% DMSO+35 % PEG 300+2% Tween 80+ddH2O up to 6 mg/ml. The gavage formula is 1%CMC-Na up to 30 mg/ml (suspensions).

  • 问题 2:

    What is difference between S7023 & S8102?

  • 回答:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

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