Z-VAD-FMK

目录号:S7023

Z-VAD-FMK Chemical Structure

Molecular Weight(MW): 467.49

Z-VAD-FMK是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。

规格 价格 库存 购买数量  
RMB 962.65 现货
RMB 3841.92 现货
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客户使用该产品的5个实验数据:

  • (A) LAN5 cells were untreated (top panels) or treated with 50 µM of the caspase inhibitor Z-VAD-FMK (bottom panels). Cells were co-treated with nothing (No Rx), 1 µM GSK-J4, or 1 µM venetoclax for 48 hours and assayed for apoptosis by flow cytometry.

    Science, 2018, 10(441), doi: 10.1126/scitranslmed.aao4680. Z-VAD-FMK purchased from Selleck.

    After treatment with 1.5 g/l matrine in the presence or absence of 10 nM Baf A1 or 20 nM rapamycin or 10 lM z-VAD-FMK (zVAD) for 24 hrs, the cell viability was measured by CCK-8 assay. Results were expressed as mean±S.E.M. representing at least three independent experiments. *P < 0.05, versus matrine alone group.

    J Cell Mol Med, 2017, 21(6):1171-1181. Z-VAD-FMK purchased from Selleck.

  • (A and B) Western blot analysis examining the effect of zVAD-fmk on the icaritin-induced apoptosis. The caspase inhibitor zVAD-fmk could significantly decrease the icaritin-induced cleaved caspase-3 expression. β-Actin protein levels indicate that an equal amount of protein was loaded into each lane.n=3. Mean±SD. bP<0.05, compared to the control group. eP<0.05, compared to the icaritin-treated group.

    Acta Pharmacol Sin 2014 35(4):531-9. Z-VAD-FMK purchased from Selleck.

    Active caspase-3 expression analysis. SW1116 cells were treated with ZBH-1205, CPT-11 and SN38 at 25 μmol/L for 48 h, in the presence or absence of Z-VAD-FMK (50 μmol/L, 1 h ahead of time). *P= 0.0345. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). E: Cell cycle analysis. F: Apoptosis analysis. #P=0.0259. Z-VAD-FMK(-) vs. Z-VAD-FMK(+). ALL experiments were repeated three times.

    Arch Biochem Biophys, 2016, 604:74-85.. Z-VAD-FMK purchased from Selleck.

  • Effect on the RAS of CFZ, z-VAD-fmk, or CFZ + z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Western blot analysis of ATF2 and pATF2. CP, ZP and UP were treated for 5 days; CT, ZT, UT and CC were treated for 12 days. CFZ (CP), z-VAD-fmk (ZP), CFZ + z-VAD-fmk (UP), PBS only (CC), healthy control (HC).

    Med Oncol, 2015, 32(4): 538 . Z-VAD-FMK purchased from Selleck.

产品安全说明书

Caspase抑制剂选择性比较

生物活性

产品描述 Z-VAD-FMK是一种细胞渗透性的,不可逆泛caspase抑制剂,在THP.1 和 Jurkat T细胞中阻断细胞凋亡的所有特性。
特性 Z-VAD-FMK是研究细胞凋亡的一种关键化合物。
靶点
Pan-caspase [1]
(THP.1, Jurkat T-cells)
体外研究

Z-VAD-FMK(10 mM)作用于THP.1细胞,抑制细胞凋亡。Z-VAD-FMK(10 μM)作用于THP.1细胞裂解液,抑制PARP蛋白酶活性的激活。Z-VAD-FMK(10 mM)作用于完整THP.1和 Jurkat细胞,抑制CPP32加工。[1]Z-VAD-FMK(50 μM)与Camptothecin共处理HL60细胞,废除Camptothecin处理的细胞凋亡形态。Z-VAD-FMK(50 μM)作用于HL60细胞,抑制Camptothecin诱导的DNA分裂。[2]Z-VAD-FMK (50 μM)作用于S2细胞,提高转染细胞的生存百分数从26%提高到63%。[3]Z-VAD-FMK(>100 μM)作用于人类嗜中性粒细胞,增强TNFα-诱导的中性粒细胞凋亡,较低浓度(1-30 μM)时完全抑制TNFα刺激的细胞凋亡。[4]Z-VAD-FMK (10 mM) 作用于早期角膜基质细胞,抑制细胞凋亡。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
GC1a NG[4W3lCeG:ydH;zbZMhSXO|YYm= MmrFOVDPxE1? NIHmNogzPGh? NXKwR|I3cW6maXPheIV{KGFicILveIVkfGm4ZTDl[oZm[3RiYXfhbY5{fCCndH;wc5Nq\GV? NG\V[WczPjF4OUC3OS=>
HGL5 NF\xbIdCeG:ydH;zbZMhSXO|YYm= MYi1NO69VQ>? MkWzNlRp MYDpcoRq[2G2ZYOgZUBxem:2ZXP0bZZmKGWoZnXjeEBi\2GrboP0JIV1d3Cxc3nk[S=> M3zle|I3OTZ7MEe1
HepG2 NUjJdYI3SXCxcITvd4l{KEG|c3H5 M{f4O|Ix|ryP M2jsWFFp NFrRTmFifHSnboXheIVlKHSqZTDhdI9xfG:2aXOgbY5lfWO2aX;uJI9nKEmLST2xNOKh MXyyOlE3PDd7NR?=
BEL-7402 Mk\CRZBweHSxc3nzJGF{e2G7 MljYNlDPxE1? NVPFZlBGOWh? M{jxZoF1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> NIL0T48zPjF4NEe5OS=>
CEF M{fsSWtqdmG|ZTDBd5NigQ>? M4LJWVAtOzNuNkesNVAx|ryP MY[xOY1qdg>? NHruO5Vld3ewLYLl[5Vt[XSnczDQVkBmdnq7bXWgZYN1cX[rdImgeI8hPDExvJWgZZQhOTByzszN NYrPboo2OjZzMEKzN|k>
SP2/0 M{K1Z2Fxd3C2b4Ppd{BCe3OjeR?= MXWxNFDPxE1? NV:2N4xqOWh? M3L5fGROW09? M3m4UIJtd2OtczD0bIUh[XCxcITvd4l{KG:oIGPQNk8xKGOnbHzz NVzu[JJCOjZyN{S3N|I>
HUVEC-2c NGDLUYtCeG:ydH;zbZMhSXO|YYm= M3XmRlUx|ryP M3HMN|Zp M3vRdYRm[3KnYYPl[EB1cGVib4itUGRNNWmwZIXj[YQh[XW2b4DoZYd6 MXqyOlAzOTd{OR?=
U1 MlLTRZBweHSxc3nzJGF{e2G7 MVKwMVExOM7:TR?= M1y0RlJp MoTzdoVlfWOnczDkdpVoNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDzeYJ{\XG3ZX70JGhKXi1zIILldIxq[2G2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy NGDsTI4zPTl6MEm0Ni=>
ACH-2 MWHBdI9xfG:|aYOgRZN{[Xl? MY[wMVIxOM7:TR?= NXXZfWtjOmh? NWHRZ3E2emWmdXPld{BlenWpLXnu[JVk\WRiYYDvdJRwe2m|IHHu[EB{fWK|ZYH1[Y51KEiLVj2xJJJmeGyrY3H0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz MYKyOVk5ODl2Mh?=
U1 NIHCSIRMcW6jc3WgRZN{[Xl? NGjRZlUyODEQvF2= MkfVNog> NFfpPVBqdmirYnn0d{Bk[XOyYYPlMVM> MXKyOVk5ODl2Mh?=
A549/V16 MorwRZBweHSxc3nzJGF{e2G7 NWLl[Vg6PTEQvF2= NGTRXVQycA>? M4j3VZJmeHKnc4Pld{BVTy:WTT3pcoR2[2WmIHHwc5B1d3Orcx?= NFTPUmszPTl2NkCzNy=>
SGN NFTLUI9CeG:ydH;zbZMhSXO|YYm= NICxdYQzOG2P NXzI[Y5HPDiq NUHjSpNocGG|IH7vJIlv\my3ZX7j[UBwdiCDSV[sJINidHCjaX6g[ZhxemW|c3nvckBweiClZXzsJIFxd3C2b4Ppdy=> NVezNmFvOjV6N{S2N|M>
HCT116  M1;4WGFxd3C2b4Ppd{BCe3OjeR?= M3PzO|Ux|ryP MWeybC=> MXXpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IFTEWnA> MYmyOVg3QDhzOB?=
DTK-SME NH3BeWZCeG:ydH;zbZMhSXO|YYm= NUH1bJJYPTEQvF2= NUXEOI9EOmh? MmLISG1UVw>? MUPwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IHL1dIl3[WOjaX7l NFzLPJkzPTh2M{i5Oy=>
HL-60 MYTBdI9xfG:|aYOgRZN{[Xl? MkLhOVDPxE1? NHLWVYg1QGh? NEL1[I1z\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KFONST3JTUB1emWjdH3lcpTDqA>? NHzqNW8zPTh{NEC0Ny=>
U937 MoTaRZBweHSxc3nzJGF{e2G7 NGfIWJo2OM7:TR?= NWHZdGV[PDiq NUfaNVl{emWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCVS1mtTWkhfHKnYYTt[Y51yqB? NHfSbY4zPTh{NEC0Ny=>
A549 NH[5bYRCeG:ydH;zbZMhSXO|YYm= NHLpclIzOCEQvF2= M{DzWVI1cA>? NEn2V3Nz\WS3Y3XzJINmdGxiZHXheIgh[2G3c3XkJIJ6KEiIQ2CgeJJm[XSvZX70 NEXyXI4zPTd7NEG0PS=>
HeLa NFnhS5FCeG:ydH;zbZMhSXO|YYm= M4f6V|Ex|ryP MYW0PIg> NU\z[3FM\GWlbHnu[ZMhfGinIILheIUhd2ZiYYDvdJRwe2m|IHTyZY1ifGmlYXzsfS=> MmKyNlU4PzJ3NEW=
SGC-7901 M{HtZ2Fxd3C2b4Ppd{BCe3OjeR?= NFe0VHIzOMLizszN NEnwPXQycA>? M37jdolvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgc5hidGmybHH0bY4> Ml7rNlU4PjdyN{[=
MCF-7 NELUSGhCeG:ydH;zbZMhSXO|YYm= M{n6cVEx|ryP Mmn6Nog> M3nGb4lvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgN2I> M3vtWFI2PzJ{MUG0
A549 NEjhPWhCeG:ydH;zbZMhSXO|YYm= M3uwOVExKM7:TR?= M1PIc|I1cA>? MXvEUXNQ NYDuVmdseHKxbX;0[ZMhUEKFLYTy[YF1\WRiQUW0PUBk\WyuIIP1dpZqfmGuID[gZZR1\W63YYTld{B1cGViY3zlZZZm\CCSQWLQJIV5eHKnc4Ppc44> NEDUN2MzPTZ6M{W2PC=>
U87 MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HkclUx|ryP M3j0RlFp M1PUV5Jm[2:4ZYLzJINmdGxiZ4Lve5RpKG[{b32gWG1bKHS{ZXH0cYVvfA>? NU\xVGJsOjV4OEG2Olg>
Neocortical Neuron M33wd25mfXKxdH;4bYNqfHliQYPzZZk> MnfRNVAx|ryP NFHVdYkycA>? MkC5ZY51[Wexbnn6[ZMhUG:rYX3p[IUhSS2LbnT1Z4VlKE6ndYLveI95cWOrdIm= Mn3qNlU3PzVyMEG=
Primary human placental cytotrophoblasts NFHUOIdCeG:ydH;zbZMhSXO|YYm= MnzvN|DPxE1? Mon5NlRp NHnwZWRFVVOR NWr0O|FsemW4ZYLz[ZMhfGinIHnubIljcXSrb36gc4YhOTIQsj3IV2QzKGK7IITybYNtd3OjbtMg MmKzNlU3PDJ3OUK=
MM NWDXNZM4SXCxcITvd4l{KEG|c3H5 NVvwVHZIPTEQvF2= NVHvWGlwOjCvaX6= NVHWfmdleGG{dHz5JIlvcGmkaYTzJHNJUy2rbnT1Z4VlKCClZXzsJIRm[XSq NIDCNmIzPTV|MEC5PC=>
DLD1 M362eWFxd3C2b4Ppd{BCe3OjeR?= MUSyNOKh|ryP MXexbC=> NI[4UGxx[XK2bImgdoV3\XK|ZYOgZ4VtdCCjcH;weI9{cXNiY3H1d4VlKGK7IGfTVFE> MVSyOVUzPDJ2Nh?=
MDA-MB-231 NUP5[pUyS3m2b4TvfIlkcXS7IFHzd4F6 M{LQe|Ex|ryP NGfmemwycA>? MojOZZVodWWwdIOgZ4VtdCCmZXH0bEBi\nSncjDDTHVCKHS{ZXH0cYVvfA>? MXOyOVUzOTVyMR?=
MKN28 M2rEb2Fxd3C2b4Ppd{BCe3OjeR?= Mmj6NVDPxE1? Mki1N|BucW5? M2K1NWROW09? NV7iUIlzcW6qaXLpeJMhXE6ILd8xJJBtfXNiQ1jYMYlv\HWlZXSgZZBweHSxc3nz MVeyOVUyOzl4MB?=
HL-60 MUXDfZRwfG:6aXPpeJkhSXO|YYm= NX:3PVZYOTByzszN NX7nW3JZOWh? Ml7kSG1UVw>? NHrNVpHDqGmvcILveoV{KH[rYXLpcIl1gSCxZjDUR25Cey22cnXheIVlKGOnbHzz MU[yOVUxOjl|Mh?=
AGS NXfQeZF3SXCxcITvd4l{KEG|c3H5 NXj1[4F4OTEQvF2= NGfwV3kycA>? MYHwdoV3\W62czDjeZJkfW2rbj3pcoR2[2WmIHPs[YF3[WenIH;mJINie3Cjc3WtN{whNThuIHHu[EAuQSCycn;0[Ylvew>? M2WwV|I2PDl{MkG0
A549  NIPDTWdCeG:ydH;zbZMhSXO|YYm= M2rISVEx|ryP NImxOIszPGh? Mm\pZoxw[2u|IFTNRXMucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiYX7kJIFxd3C2b4TpZ{Bk\WyuIHTlZZRp NV3weFJsOjV2M{S5PFk>
INS-1 MnTHRZBweHSxc3nzJGF{e2G7 NG\oc2Y2OM7:TR?= MnvHOog> MWXEUXNQ NGXub45l\WO{ZXHz[ZMhfGinIIDyc5BwenSrb36gc4Yh\WG{bImgZZBweHSxdHnjJINmdGy|wrC= MlnQNlU1OzB6OUe=
Primary hepatocytes  MVvBdI9xfG:|aYOgRZN{[Xl? NHH0UYc2OM7:TR?= Mk\zNVhp M3HFNIlvcGmkaYTzJIFxd3C2b4Ppd{Bw\iCqZYDheI9kgXSnczDpcoR2[2WmIHL5JGFkfCCGIHHu[EBVVkZvzsG= MnvNNlU1ODd3M{i=
L929-A  NXftNo5LS3m2b4TvfIlkcXS7IFHzd4F6 MUSyNOKh|ryP NHztclgzPGh? NYPlNolvcW6qaXLpeJMhXE6IzsGtbY5lfWOnZDDj[YxtKGSnYYTo NYf0dIExOjV|OUi1OFA>
L929-N M1XJVWN6fG:2b4jpZ4l1gSCDc4PhfS=> MnOyNlDDqM7:TR?= MmPGNlRp Mmi1[Y5p[W6lZYOg[IVifGhidnnhJIF2fG:lcnnu[UBVVkcQsTDwdo9lfWO2aX;u M1fUcFI2Ozl6NUSw
Cytotoxicity Assay M1fWemNmdGxiVnnhZoltcXS7IFHzd4F6 M3jQOlIx|ryP Mn75OFhp MmPFdJJmfmWwdDDNTG1FNWmwZIXj[YQh[2WubDDk[YF1cA>? NXX0N2Z2OjV|OUKxNVY>
COS7 MorRT4lv[XOnIFHzd4F6 NV;1RnlsOTEQvF2= MYSyOIg> MXXpcoNz\WG|ZYOgZ4F{eGG|ZTCzM|ch[WO2aY\peIlmew>? MUOyOVM5PDB{NR?=
COS7 M3HYbGFxd3C2b4Ppd{BCe3OjeR?= Ml7TNVDPxE1? MXO0PIg> NXvh[mRqeGG{dHnhcIx6KHC{ZY\lcpRm\CCIQ{GwNU1qdmS3Y3XkJINmdGxiZHXheIg> MWCyOVM5PDB{NR?=
A375 M{DRc2Fxd3C2b4Ppd{BCe3OjeR?= NInJUlQ{OM7:TR?= NGj3TpgzcA>? MnXjdJJmfmWwdIOgeIhmKGS{dXetbY5lfWOnZDDQRXJRKGOuZXH2ZYdm M1nTXlI2Ozd4MUG1
A549 Mnn0RZBweHSxc3nzJGF{e2G7 MoX6OVDPxE1? NVnaV4M4OjSq NYTMelNSemW4ZYLz[ZMhemmkb4PvcYUh[mmxZ3Xu[ZNqeyCjbnSgZZBweHSxc3nzJINifXOnZDDifUAhS2iran;u[4Ridg>? NVroNGM{OjV|NEm3PFE>
A549 MXzBdI9xfG:|aYOgRZN{[Xl? MX6yMlUuOjYQvF2= NWXISXh7OWh? Ml[y[IVkemWjc3XzJJRp\SCyb4D1cIF1cW:wIH;mJIFxd3C2b4TpZ{Bk\WyuczDk[ZBmdmRib36gZ49v[2WwdILheIlwdnN? M3vpT|I2OzR{NEK3
 NBL-W-S  NETVOY1CeG:ydH;zbZMhSXO|YYm= MY[1NO69VQ>? Mk\sNYg> Mnqy[pVtdHlicnXzZ5VmeyClZXzsJJZq[WKrbHn0fUBi\nSncjDHRW5VNTZzIITy[YF1dWWwdB?= MnHjNlU{OjN{MkK=
Caki-1  M4HQTmFxd3C2b4Ppd{BCe3OjeR?= MXm0NO69VQ>? Ml\qOFhp NYrsdlNwemWmdXPld{B1cGViboXtZoVzKG:oIFHucoV5cW5iVj3wc5NqfGm4ZTDj[Yxtew>? NVXYNIlHOjV{N{mxPVE>
769-P NYjKUJVKSXCxcITvd4l{KEG|c3H5 NVnDcm1xPDEQvF2= NVLESGtRPDiq NHe4U49z\WS3Y3XzJJRp\SCwdX3i[ZIhd2ZiQX7u[ZhqdiCYLYDvd4l1cX[nIHPlcIx{ MYGyOVI4QTF7MR?=
H9c2 MnjvRZBweHSxc3nzJGF{e2G7 NH;nVJg2OM7:TR?= NF;SV4oycA>? MnGybY5pcWKrdIOgSG9ZNWmwZIXj[YQh[2G|cHHz[UA{KGGldHn2ZZRqd25iYoX0JI5wfCC2aHWgcI9{eyCxZjDj[Yxtew>? MWCyOVI5OzhzOR?=
K562 M3rsfWFxd3C2b4Ppd{BCe3OjeR?= MXu1NO69VQ>? MX[0bC=> MoXIbY5pcWKrdIOgToFkNUFvaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> NUTLNpZHOjV{NEG2NVk>
L929 MYLBdI9xfG:|aYOgRZN{[Xl? NX25Sox2OTEQvF2= NHn4cnc3cA>? NGT4b4tqdmS3Y3XzJI5m[3KxcITvd4l{KHerdHigWG5H MYqyOVE6PTZ4MB?=
A549 MVLBdI9xfG:|aYOgRZN{[Xl? MWWxNO69VQ>? NXrEeJppO2h? NUPmfnU{emWmdXPld{Bk\WyuIHHwc5B1d3OrczDjZZV{\WRiYomgVHFS MkSwNlUyPjF4OUm=
MCF-7 NETCXlZCeG:ydH;zbZMhSXO|YYm= NVO1V4JCOjEQvF2= MlG2Nog> MkPo[IVkemWjc3XzJGtFWi2|aWLORU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NGjnO2EzPTF6MkK0NC=>
OS NXLKfnF7SXCxcITvd4l{KEG|c3H5 NGrUWoUzOC92MN88US=> NEfm[Wg4Omh? MUHpcohq[mm2czDPV{Bk\WyuII\pZYJqdGm2eTDy[YR2[3Srb36gZpkhSzZiY3XyZY1q\GV? MkDBNlUyPTJ|OUm=
HUVECs NGL6dHpCeG:ydH;zbZMhSXO|YYm= MknjNVDPxE1? MofKNog> NWftT3J5yqCrbnjpZol1eyCjcH;weI9{cXNiYX7kJIZi[2muaYTheIV{KGG3dH;wbIFogSCrbjDESW5XOi2rbn\lZ5Rm\CCKVW\FR5M> MnznNlUyOzh5MEO=
EA.hy926 NVnrUoVuSXCxcITvd4l{KEG|c3H5 Mn3XNVDPxE1? M{fqPVJp MX9CpIlvcGmkaYTzJIFxd3C2b4Ppd{BidmRiZnHjbYxqfGG2ZYOgZZV1d3CqYXf5JIlvKESHTm[yMYlv\mWldHXkJGVCNmi7OUK2 NWH6PWV2OjVzM{i3NFM>
Ebs NWnrUpVZSXCxcITvd4l{KEG|c3H5 MWKxNE0yODEQvF2= NXvqZVZpOjSq MmjLxsBOVVSVIHflcoVz[XSrb36gdoF1\SCmZXPy[YF{\WRiYYOgeIhmKGOxbnPlcpRz[XSrb36gc4Yhgi2YQVSu[o1sKGmwY4LlZZNm\A>? M{OzVVI2OTN2OEG3
Jurkat NWq1XIxpSXCxcITvd4l{KEG|c3H5 M2X2dVIx|ryP Mn[4NlRp NFLt[m1FVVOR MmnkdIFzfGmjbHz5JIlvcGmkaYSgZ4VtdCCmZXH0bEBw\iCMdYLrZZQh[2WubIOgbY5lfWOnZDDifUAyODB3OD3GOEBkd22kaX7l[EB4cXSqIG\QReKh MoDGNlUyOjB5MkO=
K562 Mom4RZBweHSxc3nzJGF{e2G7 NIjuV4cxNjFvMd88US=> MU[xbC=> M3vYfolvcGmkaYTzJINt\WG4YXflJI9nKEiVUEmwJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M1rzZlI2OTF7MUi4
IMR-32 NV74[Hc1SXCxcITvd4l{KEG|c3H5 M13XR|QxyqEQvF5CpC=> Mn\WNog> M4rpc4Rm[3KnYYPlJIlvKGGyb4D0c5Rq[yClZXzsd{Bkd22yYYLl[EB1dyCWLUKgeI95cW5? M{Xze|I2ODh2N{W1
RPMI 8226 M1XUbWFxd3C2b4Ppd{BCe3OjeR?= MXGxNFDPxE1? MlfTNYg> NYrU[Xlt[Wyvb4P0JINwdXCuZYTlcJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= MXeyOVA{Pzh3MR?=
U266  MWDBdI9xfG:|aYOgRZN{[Xl? MkXZNVAx|ryP M1vrNlFp NH\5bFFx[XK2aXHscJkh[myxY3vzJINmdGxiZHXheIgh[2G3c3XkJIJ6KG6nY4Lvd5RifGmwLUG= NGLoO2EzPTB|N{i1NS=>
H929  NYnONmtoSXCxcITvd4l{KEG|c3H5 M{\IXFExOM7:TR?= Ml;SNYg> M1f5[JBienSrYXzsfUBjdG:la4OgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhdmWlcn;zeIF1cW5vMR?= M2jHOlI2ODN5OEWx
MM.1S  NYXpOYVFSXCxcITvd4l{KEG|c3H5 MYOxNFDPxE1? NHmxOnAycA>? NGn4XlZm\m[rY3nlcpRtgSCycnX2[Y51eyC|b4Lh[oVvcWJvaX7keYNm\CClZXzsJIRm[XSqIHPvcYJqdmVid3n0bEBv\WO{b4P0ZZRqdi1z NYn3RZlLOjVyM{e4OVE>
C6 MmPmRZBweHSxc3nzJGF{e2G7 NX7aXoFvPTEQvF2= MnfCOFhp M3vqSZBz\X[nboTzJJRp\SCub4PzJI9nKGOnbHygeoli[mmuaYT5JINifXOnZDDifUBxemWpbnXuc4xwdmV? M{K4NlI2ODF|NEe5
AGS NY\DU|JsSXCxcITvd4l{KEG|c3H5 Mnu5OVDPxE1? NFPtZZQzPGh? NWPNW3Rx[WKxbHnzbJMh|rJvbHHwZYNpd26nLXnu[JVk\WRiY3XscEBl\WG2aDDhcoQhcW6qaXLpeIVlKGe{b4f0bC=> M{TV[FI2ODB7Nkm4
HeLa  Mni4RZBweHSxc3nzJGF{e2G7 NVjveoR7PDEQvF2= MW[yOIg> NVrBT|d[cW6qaXLpeJMhfGinIHnuZ5Jm[XOnZDDhdI9xfG:|aYOgbY5lfWOnZDDifUB{cVKQRkGyNS=> MYWyOFkzQDZ6NR?=
THP-1  MorHRZBweHSxc3nzJGF{e2G7 MWSxNO69VQ>? MUexbC=> M{fKSJJm\HWlZYOgZZBweHSxc3nzJIlv\HWlZXSgZpkhSUyDLWPEWOKh NWi0SpljOjR7MkO2OVM>
P815  NWjISm0{SXCxcITvd4l{KEG|c3H5 M370PVExOCEEtV2= M4e1blEzcA>? NYXhcol2TE2VTx?= MYXpcohq[mm2czD2bZJ2ey2rbnT1Z4VlKGGyb4D0c5Nqew>? NGOxXFMzPDl{M{K3Ny=>
HCT116 MUXBdI9xfG:|aYOgRZN{[Xl? MmTCNlDPxE1? NYjucFRGOjSq M{nrb4Fjem:pYYTld{Bw\iCWUT3pcoR2[2WmIHHwc5B1d3Or M1zRTFI1QDlyNES5
SW1116  NXHMPJBSSXCxcITvd4l{KEG|c3H5 MYSxNEDDvU1? NFLxR4MycA>? NFK0[otFVVOR MoTndoV{fHKjaX7zJINmdGxiYYDvdJRwe2m|IHnu[JVk\WRiYomg[4VncXSrbnniJJBtfXNiZHXjbZRi[mmwZR?= NILQVogzPDh5NEK4Oi=>
LOVO M2HQWGFxd3C2b4Ppd{BCe3OjeR?= MUCxNEDDvU1? NEfvXGQycA>? MoL0SG1UVw>? MVny[ZN1emGrboOgZ4VtdCCjcH;weI9{cXNiaX7keYNm\CCkeTDn[YZqfGmwaXKgdIx2eyCmZXPpeIFjcW6n MlnnNlQ5PzR{OE[=
SNU449  NGfjTINCeG:ydH;zbZMhSXO|YYm= NX\WXnNVOjEQvF2= NH;BNYc1QGh? NVKy[5VzTE2VTx?= Mkew[IVkemWjc3XzJI1qWi12NUGtbY5lfWOnZDDhdI9xfG:2aXO= MV:yOFg1OTZ|OB?=
Caco-2 NEHOfJhCeG:ydH;zbZMhSXO|YYm= M3jJb|Qx6oDLzszN M3L6NFRp MXHwdoV3\W62czDTWE04NWmwZIXj[YQhYk9vMTDjbIFv\2W|IHHu[EBVTVJiZILvdC=> MXOyOFgzOjF6Mx?=
macrophage NELxcnFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NGi1THoxNTJyMN88US=> NV\uSlgzOjSq NWm0bGVvcW6mdXPld{BVVkZvIHHu[EBTcXB|LXTldIVv\GWwdDDu[YNzd3C2b4Ppd{BqdiCvYXPyc5Bp[Wen NYHYeWpPOjR5OUm1OlU>
AGS  M17LU2Fxd3C2b4Ppd{BCe3OjeR?= NX7MV5pnOjEQvF2= NFnIeG8yOmh? NEfafY1FVVOR M3;wVJJm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZjDhdI9xfG:|aYOgbY4hemW|cH;ud4UhfG9idHjlJGV1V0GlIH\yZYN1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NFPuRnQzPDd6OUewNy=>
LCC9  NYC4T|hCS2WubDDWbYFjcWyrdImgRZN{[Xl? NX7zeXRpOTByzszN NVnaeJllPWR? MkLBZoxw[2u|IHPlcIwh\GWjdHigbY5lfWOnZDDifUBkd22kaX7heIlwdiCOMUegZY5lKGOqbH;yc5F2cW6n MYKyOFc5PTJ3Nh?=
U937  MoPNcoVkem:ydH;zbZMhSXO|YYm= M1zGTlExyqEQvF2= NFrkTpk{OMLibXnu MnfZbY5lfWOnczDu[YNzd3C2b4Ppd{Bkd22kaX7lJJdqfGhiVF7G NX3KZoxkOjR5N{O3OVY>
T cell NVfvWGZsS2WubDDwdo9tcW[ncnH0bY9vKGG|c3H5 NVT0O4FrOC1zMEFOwG0> NFjLVYQ4Omh? MWHJR|UxRTdyIN88UUwhcW6qaXLpeJMh[W62aT3DSFMucW6mdXPl[EBVKGOnbHygdJJwdGmoZYLheIlwdiCrbjDQRm1Eew>? NY\KdIxWOjR5Nki3NFc>
HeLa  NHX3bJlCeG:ydH;zbZMhSXO|YYm= Mo\LOVDPxE1? MXq3Nog> M1OyZWROW09? MojLdJJmfmWwdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2:vcH;1coR{yqBz4pETOS=> MlzUNlQ4PTR5OE[=
HeLa  NIHrd2ZCeG:ydH;zbZMhSXO|YYm= NEjPSVEyODEQvF2= MVeyOIg> NUTvVXl4e3WycILld5NmeyC{YYTlJI9nKGOnbHyg[IVifGhiaX7keYNm\CCkeTDveoVz\XiycnXzd4lwdiCxZjDHOVlUKG:{IFe3NXIheDF3MHfseYVlyqB? NFi4S4UzPDd{MkS2PC=>
IEC-6  NF72e|RCeG:ydH;zbZMhSXO|YYm= MnvzNVDPxE1? NV:5d|FxOjSq M1HqfZBz\X[nboTzJHRk\EFvaX7keYNm\CClYYPwZZNmNTNiY3zlZZZi\2ViYX7kJO6zNWOjdHXubY4h\GWpcnHkZZRqd25? NEWxRZgzPDdzMUW3NS=>
HCT116 NV32cHFzSXCxcITvd4l{KEG|c3H5 MoXpNlDPxE1? M{Kxe|I1cA>? NUfr[oJycW6qaXLpeJMhfGinIHPlcIwh[XCxcITveIlkKGmwZIXj[YQh[nliWVzUNlA2 NWfSbVY1OjR5MUO4NVI>
L02 M2fOXGFxd3C2b4Ppd{BCe3OjeR?= NGHub28zOM7:TR?= Mm\xNYg> NE\jN|RxemW4ZX70d{B1cGViY3XscEBieG:ydH;zbZMhcW6mdXPl[EBjgSCPRVjQ NV3uOJZrOjR5ME[0OlE>
A375 NGrnZ5BCeG:ydH;zbZMhSXO|YYm= M{XUUFIx|ryP MoDRNlRp MnPpdoV3\XK|ZYOg[IlkcXS{aX7vcoUhSi2rbnT1Z4VlKGGyb4D0c5Nqew>? M3:2WFI1Pjl7MUGx
HDPC NXHqcpdJSXCxcITvd4l{KEG|c3H5 M1X4R|UxyrWP NVLMfWVXOjSq MYTpcohq[mm2czDOU{1qdmS3Y3XkJIFxd3C2b4Ppdy=> NIXtVokzPDZ|NEW5Ny=>
A549 MXTBdI9xfG:|aYOgRZN{[Xl? M3mzblUxyrWP MnH1Nog> MY\EUXNQ M1[xTJBz\X[nboTzJJRp\SCqeYDv[IlxdG:rZDDEUmEh[2:wdHXueEBxcGG|ZTDpcoR2[2WmIHL5JINmeGijbH;jbJJwdWmw MlfnNlQ2QDhzM{W=
 BV-2 MoDsRZBweHSxc3nzJGF{e2G7 MX:yNO69VQ>? M4q5SVJp MV;zeZBxemW|c3XzJHVXNWmwZIXj[YQh[2i{b33heIlvKGW6dIL1d4lwdiCjbnSg[Ilt[XSrb36gc4YhfGinIH71Z4xm[XJiZX72[YxweGV? MXWyOFU2QDFzOB?=
HT-29  NGHVNVVCeG:ydH;zbZMhSXO|YYm= M4HMUFUx|ryP M3fweFQ5cA>? NV\MT4dV[myxY3vzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDrZYVueG[ncn;s M3fteFI1PTR7MUe1
A549 MVnBdI9xfG:|aYOgRZN{[Xl? NFTwT2I2|ryP NXHsVnVjOjSq M1G0OpN2eHC{ZYPz[ZMhPmYEoDjCT|ExODRyKT3pcoR2[2WmIHHwc5B1d3Orc9Mg M4DiflI1PTJ7OEex
MIA-PaCa-2 NEfoOnVCeG:ydH;zbZMhSXO|YYm= MXmyOIg> NFeyN|JjdG:la4OgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{KGmwZIXj[YQh[nliYn;0bEBCNTR2M{[1OEBidmRicHHjcIl1[XinbB?= MWiyOFUyODl7Mh?=
Caki-1 MkjGRZBweHSxc3nzJGF{e2G7 NYLrRo5GOjEQvF2= MmTPNYg> MUHpcohq[mm2czDTR3AucW6mdXPl[EBieG:ydH;zbZM> MXOyOFUxPDZ6MR?=
CLL MVLBdI9xfG:|aYOgRZN{[Xl? NWq5T5lzOjYQvF2= MlzaNYg> M121T5BienSrYXzsfUBjdG:la4OgUWxPOjJ|OD3pcoR2[2WmIHPlcIwh[XCxcITvd4l{ MX[yOFQ3PzZ|NB?=
SGC-7901 Ml\TRZBweHSxc3nzJGF{e2G7 MlHoNVDPxE1? NEDSN2szPGh? M{jofZBzd22xdHXzJJRp\SCFR1nJMYlvcGmkaYTl[EBk\WyuIHfyc5d1cCCrbjDTS2MuPzlyMTDj[Yxtew>? Ml\INlQ1PTR2OEi=
k1735 MVLBdI9xfG:|aYOgRZN{[Xl? NHfWZogzOOLCid88cS=> NXHXeHN3PGh? MW\pcohq[mm2c9MgV4FtdW:wZXzsZU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NHfjZmgzPDR3MUGxOi=>
HaCaT  M{ix[GFxd3C2b4Ppd{BCe3OjeR?= M{nxclExOM7:TR?= M3f0TFFp M4HOfoJtfW62czDVWmIucW6mdXPl[EBieG:ydH;zbZMhcW5iSHHDZXQh[2WubIO= NXvQcmFtOjR|NU[5PVc>
podocytes M{\PUGFxd3C2b4Ppd{BCe3OjeR?= MUiyNFDPxE1? MUC2bC=> NVr1d41KcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliMzy0MWRITQ>? M{fLOVI1OzN5N{e3
 KB MV3BdI9xfG:|aYOgRZN{[Xl? NFzhT5Y2OM7:TR?= Ml3MNlRp M4TFSIlvcGmkaYTzJGxq[29vQT3pcoR2[2WmIHPhd5Bie2VvMzDhcoQhWEGUUDDhZ5RqfmG2aX;u NEnyeXozPDN|N{S5Ni=>
 HepG2  NGHKR5hCeG:ydH;zbZMhSXO|YYm= M2Ph[FEx|ryP NEnGdpUzPGh? NFHIUJZz\WS3Y3XzJJZqdWWwdHnuJINt\WG4YXflJINifXOnZDDifUBNWFN? MUWyOFMzPThzNh?=
fetal rat lung fibroblasts  MX\LbY5ie2ViQYPzZZk> MXS4NO69VcLi NEnCeHQycA>? Mlr3bY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> NF23R3czPDNzNEGzOS=>
PDL fibroblasts M3ywXGtqdmG|ZTDBd5NigQ>? NH\OeZo5OM7:TdMg NHLMR|cycA>? NUDOfJZrcW6qaXLpeJMhS2G|cHHz[U0{KGGldHn2bZR6yqB? MVGyOFMyPDF|NR?=
MB49 NH:2NnBCeG:ydH;zbZMhSXO|YYm= MkfJNlDPxE1? NF;DZ|UycA>? M1mzfZJmfmW{c3XzJGNONWmwZIXj[YQh[2WubDDk[YF1cA>? MmGzNlQzQDJ2M{O=
5637 MX;BdI9xfG:|aYOgRZN{[Xl? M3HaR|Ix|ryP NFi4SZMycA>? MYny[ZZmenOnczDDUU1qdmS3Y3XkJINmdGxiZHXheIg> Ml60NlQzQDJ2M{O=
A549  MVvBdI9xfG:|aYOgRZN{[Xl? MkLINVAx|ryP MnzDOFhp NHuz[4V{fXCycnXzd4V{KHSqZTDhdI9xfG:|aYOgZ4F2e2WmIHL5JJBqeGW{aX7lxsA> NIH2VI4zPDJ5MkKwNS=>
MCC-2 MVjBdI9xfG:|aYOgRZN{[Xl? NF62S40zOCEQvF2= MVu2bC=> MnTSSG1UVw>? M1jl[YJtd2OtczDpcoR2[2WmIHL5JJN1[XW{b4Pwc5JqdmViYYDvdJRwe2m|IHPlcIwh\GWjdHi= M3ntPFI1OjZ{NkW4
ADF NEHmelhCeG:ydH;zbZMhSXO|YYm= MoL2OFDPxE1? MWq2bC=> Mn;VbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[2inbX;0bIVz[XC7IIDseZMhYm6FbEK= MVyyOFIzQDJ|Mh?=
 U373  Mnz3RZBweHSxc3nzJGF{e2G7 MUC0NO69VQ>? NWOyPJN2Pmh? M2LpcYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGOqZX3veIhmemGyeTDwcJV{KFqwQ3yy M2OwTlI1OjJ6MkOy
RKO-HIPK2i MnGxRZBweHSxc3nzJGF{e2G7 M1:0TFQx|ryP NVfPdHpFPmh? MV7pcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= MVqyOFIzQDJ|Mh?=
HEC-1B NYKwOmg5SXCxcITvd4l{KEG|c3H5 NFO0[WEzOM7:TR?= NFPoTZkycA>? NWC4RYx1emWmdXPld{BVWC2rbnT1Z4VlKGGyb4D0c5Nqe8LiY3HzdIF{\S1|IHHu[EBk[XOyYYPlMVk> NXjQUo1ROjR{MUOzOVg>
4T1 Mm\HR4VtdCCYaXHibYxqfHliQYPzZZk> M4\uflIvPS1zMN88US=> MkS5OIg> M4LVdmROW09? M3j3R5Jme2O3ZYOgeIhmKGO7dH;0c5hq[2m2eTDv[kA1XDFiY3XscJMhcW6mdXPl[EBjgSCVUFTUJIlvKGFiY3;uZ4VvfHKjdHnvckBl\XCnbnTlcpQhdWGwbnXy MXuyOFIxPjF4MR?=
OS  M3vhR2Fxd3C2b4Ppd{BCe3OjeR?= MVGyNO69VQ>? NILp[3c1cA>? NYe0UXU{cW6qaXLpeJMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JHBFXA>? M{XlOlI1OjB2OUO3
RPE M1L3[GFxd3C2b4Ppd{BCe3OjeR?= NHz2T3cyODEQvF2= MkP3OFhp NVHyXJU4eGG{dHnhcIx6KGmwaHnibZR{KHSqZTDjZYxx[WmwLUGgZY5lKC1{IHHjeIl3[XSrb36gZZMhf2WubDDhd{B1cGViY3HzdIF{\SCjY4TpeoF1cW:w M1i1fVI1OjB{MEWy
UD29a MoPxRZBweHSxc3nzJGF{e2G7 NXX3UZJKPTEQvF2= MlrGNlRp MknwbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiY3H1d4VlKGK7IF7VWFM> NUPocFR3OjRzOUC1O|Q>
SH-SY5Y  M1i2R2Fxd3C2b4Ppd{BCe3OjeR?= MnvGNVDPxE1? NHTFVlAzPGh? M{HKcYF1fGWwdXH0[ZMh[2G|cHHz[UBi[3SrdnH0bY9vKGGwZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhUE6HLULESy=> NFfBV5IzPDF2NUS2Ny=>
HeLa  Mk\HRZBweHSxc3nzJGF{e2G7 M3voT|ExNzJyzszN NInNfXEzPGh? NGTRbGJqdmirYnn0d{B1cGViYXP0bZZqfHlib3[geIhmKG2jan;ybZR6KG:oIITo[UBu\W2kZYLzJI9nKHSqZTDjZZNx[XOnLX\hcYltgQ>? NGrPc5QzPDF|N{K2Oi=>
SCCVII  M{fte2Fxd3C2b4Ppd{BCe3OjeR?= M{nXbFI2|ryP NGHH[noycA>? M{LMeIlvcGmkaYTzJJRp\SClZXzsJItqdGyrbnegZYZ1\XJiZHHzZZRqdmmk NIr4NpkzPDF{NkS2OC=>
RAW 264.7 NHr6UXpCeG:ydH;zbZMhSXO|YYm= NW\ac|JZOjEQvF2= MX:xPIg> NVLJO3Y1cW6lcnXhd4V{KEyFMz3JTU/Pui2jY4TpckBz[XSrbzDjc41x[XKnZDD0c{BGS1SYLV3PV{B1emWjdH3lcpQhd26ueR?= M3TkU|I1OTF4N{C3
A549  NFHSTlRCeG:ydH;zbZMhSXO|YYm= NEjnZVUzNjYQvF2= MoPMNlRp MnnE[IVkemWjc3XzJI9zcWSxbnnuMYlv\HWlZXSgZZV1d3CqYXf5JIF{KHenbHygZY5lKEyxc4Ogc4Yh|pURiH2gZYx{dyCxY3P1dpJm\CCmdYLpcoch[XW2b4DoZYdq[yCycn;j[ZN{ NY[xe2ZWOjRzMEK1NlI>
UM-SCC-10A  NYfXWpB4SXCxcITvd4l{KEG|c3H5 M4q4OVUxyrWP NVXHO3NGOmh? NYHKSXl5emWmdXPld{BieG:ydH;zbZMhcW6mdXPl[EBjgSCqaXfoMYRwe2ViaYPvZYxidnSxbHHjeI9v\Q>? M3z0XVI1ODl6N{Wz
BGC-823 M3jSPGFxd3C2b4Ppd{BCe3OjeR?= NFj5eVUyOCEQvF2= Mmq0NlRp NIP4cJZz\WS3Y3XzJJRmfHKjbnTybY5mNWmwZIXj[YQh[XCxcITvd4l{yqB? MmrlNlQxQTh3MUG=
Nalm-6  MlnDRZBweHSxc3nzJGF{e2G7 Ml7UNlDPxE1? MVi0bC=> M2L2[YlvcGmkaYTzJINie3Cjc3WtPEBidmRiY3HzdIF{\S1|IHHjeIl3[XSrb36gZY5lKFCDUmCtNUBkdGWjdnHn[S=> MmLpNlQxOzl7Nke=
KHOS  NWjQe25NSXCxcITvd4l{KEG|c3H5 MoH1OFDPxE1? M3vRUFI1cA>? NWTXd29S[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> NFzLVZIzPDB{NUO2NS=>
G292 M3PjU2Fxd3C2b4Ppd{BCe3OjeR?= MnXzOFDPxE1? NVu4R|ZLOjSq Mnn2Zoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= NUT5bnk{OjRyMkWzOlE>
MG-63 MkXIRZBweHSxc3nzJGF{e2G7 MUi0NO69VQ>? NVzOT3Z{OjSq NV65cGFl[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> MYWyOFAzPTN4MR?=
EBV-transformed B cells NXH1OpFpSXCxcITvd4l{KEG|c3H5 MkXNNlDPxE1? M3PF[VJp NXf0emdvTE2VTx?= M3;lc4Jtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? NV7YNJByOjRyMEi2Nlg>
IM-9 B NH3PcVZCeG:ydH;zbZMhSXO|YYm= M1nVPFIx|ryP M{XkWVJp NXfN[3lOTE2VTx?= MmrVZoxw[2u|IHHueIkuS0R6MDDhcoQh[W62aT3DSFg3KGGwdHnic4R6NWmwZIXj[YQh[XCxcITvd4l{ M{njOlI1ODB6NkK4
CNE1 MVLBdI9xfG:|aYOgRZN{[Xl? NIT2fpQzOM7:TR?= M4W3ZVQ5cA>? M{TxNIJtd2OtczDMT{1CNWmwZIXj[YQh[XCxcITvd4l{ MWOyN|k5PTB{OR?=
CNE2 M3\obmFxd3C2b4Ppd{BCe3OjeR?= MmT5NlDPxE1? M{LVZlQ5cA>? NHHhZZhjdG:la4OgUGsuSS2rbnT1Z4VlKGGyb4D0c5Nqew>? MoLlNlM6QDVyMkm=
HL-60 Mlv6RZBweHSxc3nzJGF{e2G7 MV[1NOK2VQ>? MXSxbC=> MmPrSG1UVw>? MmnhbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhSkFzNEW= MYeyN|k1QDd3MR?=
L929 NV23UolrSXCxcITvd4l{KEG|c3H5 NFfLUIoyNjJ34pETOeKh|ryPwrC= MUmyOIg> M4O0[4F2\22nboTzJHRPTs7zLXnu[JVk\WRibnXjdo9xfG:|aYOgZY5lKGG3dH;wbIFogQ>? M1nr[|I{QTRzN{[5
Jurkat M2foTWNmdGxiVnnhZoltcXS7IFHzd4F6 NHTHSGcz|ryP NWfLZWRSPGh? NV6yT2NremW4ZYLz[ZMh\3Kxd4ToJIlvcGmkaYTpc44h[W6mIN8yMYNifGWwaX6g[IVkemWjc3WgZpkhUFNvQWPB MorkNlM5QTZyNkG=
RAW264.7  MWrBdI9xfG:|aYOgRZN{[Xl? MoHLNVAh|ryP NW\ETpdqOjSq MXnk[YNz\WG|ZYOgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IFfB MlixNlM5OjB{MEO=
A431  M{HWV2tqdmG|ZTDBd5NigQ>? NYnqVXFSPDEQvF2= M1HtUlJp NYTNO4Jo[myxY3vzJIZqe2W2aX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPld{BidmRiUFHSVC=> M4DuZVI{QDByMEW4
Jurkat MXrD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NFLTeJgzPS1zMEFOwG0> MmDTOog> MVrpcohq[mm2czD6MWZCNUOPSz3pcoR2[2WmIHPlcIwh\GWjdHi= NHS3XHAzOzl|M{WzNi=>
COS-7  MVPGeY5kfGmxbjDBd5NigQ>? NYjxPGx{PTEEtV2= MXyyOIg> NWDJb2Qx[W[oZXP0d{B1cGVicILvZ4V{e2mwZzDv[kBCXE5zczD3bZRpKHCxbInRJJRz[WO2cx?= NIHB[o4zOzl|M{KwPC=>
CAL27 MXfBdI9xfG:|aYOgRZN{[Xl? NHLVNIMyOCEQvF2= M3z1b|Jp M4HCXpN2eHC{ZYPz[ZMhS3W{LV7Qd{1z\WS3Y3XkJJZq[WKrbHn0fUBjgSC3cDD0c{A6OCV? MnXUNlM6OTd|OU[=
THP-1  NEDaUWlCeG:ydH;zbZMhSXO|YYm= MknWNVAuPTEQvF2= M2nn[FJp MlHObY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhfHKrcITvcIll\Q>? NHnUNWczOzlyMEK5PS=>
K562 NFXvZWVCeG:ydH;zbZMhSXO|YYm= NYPlbZV{OjEQvF2= NFnpN|A1QGh? MkjObY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhPC2PVR?= NVq2Z5VxOjN6N{[4NlY>
HL-60 Mon2RZBweHSxc3nzJGF{e2G7 MWGxNFDPxE1? NWrJe3V1OjSq M3ryTYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KGGkaXX0ZY5mKGSrdHXydIVv\XQEoB?= MXKyN|g3PTd5OB?=
HeLa  Mln5RZBweHSxc3nzJGF{e2G7 MkjwNlDPxE1? Mnn6Nog> M1X0T4lvcGmkaYTzJGROVVBiaX7keYNm\CCjcH;weI9{cXN? Mn7wNlM5PjN7Nk[=
U251 M{\zS2Fxd3C2b4Ppd{BCe3OjeR?= Mk\xNlDPxE1? MXmyOIg> NVfqXJZkcW6qaXLpeJMh[2G|dHnjbY4hcW6mdXPl[EBIOi:PIIDoZZNmKGG{cnXzeEBidmRiYYDvdJRwe2m| NGD2dnAzOzhzNkixOi=>
HL-60 MlnMRZBweHSxc3nzJGF{e2G7 MlnaOVDDvU1? Moq3OIg> MXjicI9kc3NidHjlJINt\WG4YXflJI9nKGOjc4Dhd4UuOyxiLUmsJIFv\CCSQWLQJIlv\HWlZXSgZpkhPnN? M{DKd|I{QDB2N{C2
Ec-109 NXGxZVQySXCxcITvd4l{KEG|c3H5 NIrrNYsyOCEQvF2= NGf1dlM1QGh? Ml\kdoVxemW|c3XzJHBGNW2nZHnheIVlKEWlLUGwPUBk\WyuIHHwc5B1d3Orcx?= MYqyN|c5OjZ2MR?=
RKO MYTD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NYDYbYlJOTBizszN MmXuNlRp MlXHbY5pcWKrdIOgeIhmKGSnY4LlZZNmKG:oIHPlcIwhfmmjYnnsbZR6KGOjdYPl[EBjgSCGQVK= M3;ud|I{PzV6ME[0
T98G M17pPGNmdGxiVnnhZoltcXS7IFHzd4F6 NGTWO|MyNTFyMN88US=> NFvJSGszPGh? M{DlU4lueHKxdnXzJINmdGxidnnhZoltcXS7IHPveJJm[XSvZX70JJdqfGhiVGO= M{TlNVI{PzZ7Mke1
Jurkat M3viU2NmdGxiVnnhZoltcXS7IFHzd4F6 MmH6NVAxNTJyMN88US=> NUXmPYZtOjSq NWLVT2lYcW6qaXLpeJMhUGGDNDDpcoR2[2W|IHHwc5B1d3OrczDk[ZBmdmSnboSgc4Yh[2:wY3XueJJifGmxbtMg MontNlM4OzJ2OEG=
Molt-3  Ml\CRZBweHSxc3nzJGF{e2G7 NV7xd2ZvPTEQvF2= M2m1S|Jp MnnVdoVlfWOnczDt[YxifG:waX6tbY5lfWOnZDDhdI9xfG:|aYO= MlLCNlM4OjVyMUO=
hMSC12 MkewRZBweHSxc3nzJGF{e2G7 NFzqOYUyODEQvF2= MoixOIQ> M1LneIlvcGmkaYTzJI9{fGWxZ3XubYMh[3WudIXy[U1qdmS3Y3XkJINmdGxiZHXheIgh[W6mIHPhcINq\mmlYYTpc44> MVeyN|Y2Pzh{Mh?=
HM7  M3nvV2Fxd3C2b4Ppd{BCe3OjeR?= M4K2O|Ix|ryPwrC= NUXsR49DOWh? NXizfWV[[myxY3vzJIFxcWO3bHHy[Y4hSSCjY3X0ZZRmNWmwZIXj[YQh[2G|cHHz[U0{KGGldHn2ZZRqd25iYX7kJHBCWlBiY3zlZZZi\2V? MUSyN|U5OzRzMh?=
Hep-2  NV;WdIRmSXCxcITvd4l{KEG|c3H5 M3\vdlIx|ryPwrC= M1rEOlI1cA>? NWqwb5FbTE2VTx?= NGHxN2tidGyndnnheIV{KHSqZTDk[YNz\WG|ZTDv[kBk\WyuII\pZYJqdGm2eTDpcoR2[2WmIHL5JJNqdGmkaX7pci=> NGLsXYYzOzV6MECzNi=>
HSCs MXrBdI9xfG:|aYOgRZN{[Xl? MkfGOVDPxE1? MXmyOIg> NWHGOGVyTE2VTx?= NF75PY1qdmirYnn0d{BvcWyxdHnubYIucW6mdXPl[EBFVkFiZHHtZYdmKGmwZHnjZZRm\CCkeTDQRXJRKGOuZXH2ZYdm MkDMNlM1QTl6N{S=
HL-60  M13YPGN6fG:2b4jpZ4l1gSCDc4PhfS=> MY[yNO69VcLi MkS4NlRp M2jXNZJm\HWlZYOgeIhmKGO7dH;0c5hq[yCnZn\lZ5Qhd2ZiRYL5OS=> MkfNNlM1QTR2OEC=
HA NGSyfGJCeG:ydH;zbZMhSXO|YYm= Mn3POVDPxE1? MoXJNlRp NITRN5Z{fXCycnXzd4V{KHSqZTDjcIVifmGpZTDv[kBRSVKSIHHu[EBk[XOyYYPlMVMtKC15LDDhcoQhNTliaX7keYNm\CCkeTDic5J1\XqxbXniM3NCUEF? M4rJPVI{PDd3OUW2
C666-1 MmfvRZBweHSxc3nzJGF{e2G7 MYW1NO69VQ>? M2LFPVI1cA>? NIGxTWt{fXCycnXzd4V{KHSqZTDjcIVifmGpZTDv[kBRSVKSIHHu[EBk[XOyYYPlMVMtKC15LDDhcoQhNTliaX7keYNm\CCkeTDic5J1\XqxbXniM3NCUEF? NV74SYZIOjN2N{W5OVY>
Hepa1-6 NFzIZ5BCeG:ydH;zbZMhSXO|YYm= MoGyOVDPxE1? MY[ybC=> NGrtbZdqdmirYnn0d{BkfXKldX3pckBidmRicnXzeoVz[XS{b3ytbY5lfWOnZDDhdI9xfG:|aYO= NIXTV5kzOzR2Nke1Ny=>
PLC/PRF/5c MnL2RZBweHSxc3nzJGF{e2G7 NHLmSJE2OM7:TR?= NGS4WngycA>? MmDDdJJmfmWwdIOgZZBweHSxc3nzJJRzcWepZYLl[EBjgSCFSV6= MVmyN|Q{QDh{NB?=
HCT116 Ml3TRZBweHSxc3nzJGF{e2G7 NXzLfZpvOTByzszN M{WzflEvPWh? NHXCXoNqdmirYnn0d{BQey2rbnT1Z4VlKGOnbHyg[IVifGh? M2PGTlI{PzR2M{Wz
HCEC NXiwfmlvTnWwY4Tpc44hSXO|YYm= MYG1NO69VQ>? MY[3Nog> NYqxS2p6TE2VTx?= M13mfpJme3SxcnXzJI9nKHSqZTDuc5Ju[WxiSFPFR{BxcGWwb4T5dIU> MYmyN|c1OjBzMR?=
Primary rat cerebral cortical neurons NUT4dJhqSXCxcITvd4l{KEG|c3H5 MYSxNFDPxE1? MnXRNYg> MXHwdoV3\W62czDD[E1qdmS3Y3XkJIFxd3C2b4Ppd{BidmRiY3XscEBl\WG2aB?= MnnrNlM4PDF|MUe=
MDA-MB-231  M2\3RWFxd3C2b4Ppd{BCe3OjeR?= M1nkPVI2|ryP NVvuSHhkOjSq NVTTdFBD[WK{b3fheIV{KGO7dH;0c5hq[2m2eTDhcoQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgVoc{ MoPNNlU{Ozd3NES=
NLRP3-Tet-on-MC/9  MmTYRZBweHSxc3nzJGF{e2G7 NFzsfVcyOC12MN88US=> NIHaUJgyOmh? MkTIZZR1\W63YYTld{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgR2FRWy2jc4PvZ4lifGWmIF7MVnA{KG23dHHueJMhcW5idHjlJHRmfC2xbjDzfZN1\W1? MYiyN|cxOzN6OR?=
KNS42  M33BU2Fxd3C2b4Ppd{BCe3OjeR?= MnHiOVDPxE1? M2LUVVFp MnnkdoVlfWOnczDj[YxtKGSnYYToJIFv\CClb33wcIV1\Wy7IHHic4xqe2inZDDjZZNx[XOnIEOvO{Bi[3Srdnn0fUBqdiC{ZYPwc45{\SC2bzDBRnQuOjZ|L{LES{9u\XSob4LtbY4h[2:vYnnuZZRqd25? MmLMNlM3QTFzNEW=
MCF-7  MmfMRZBweHSxc3nzJGF{e2G7 NVi3ZodJOjEQvF5CpC=> NX\WdIFWPzKq MVTpcohq[mm2czDldZVwdC1iYX7kJFQuV0iWLX3l[IlifGWmIHHwc5B1d3Orcx?= MnTrNlM3PzV4NEO=
hCMEC/D3  Mn\WRZBweHSxc3nzJGF{e2G7 MlHaNlXPxE1? NWPiNYZFPzKq NUD5U25qemWmdXPld{BNfHiDIHnu[JVk\WRiYYDvdJRwe2m| NFTiPVEzOzZ4NUG5PC=>
Jurkat NV\hdFRISXCxcITvd4l{KEG|c3H5 MVyxNk42NTVyzszN NYjTZXFUOWh? MUHkc5NmKGSncHXu[IVvfGy7IIP1dJBz\XO|ZYOgV3BJNWmwZIXj[YQhWGG{LUSgZ4xm[X[jZ3WsJHBCWlBiY3zlZZZi\2VuIFTORUBnemGpbXXueIF1cW:wLDDhcoQhdG:|czDv[kB3cWGkaXzpeJk> MXuyN|Q1Ojl5Nh?=
CNE-1 M2DkPGFxd3C2b4Ppd{BCe3OjeR?= NIXQXZkzOM7:TdMg Ml;HNlRp NWjBcGp7cW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> M{DBRVI{PDJ4OEWw
HONE-1 MWHBdI9xfG:|aYOgRZN{[Xl? MmPJNlDPxE4EoB?= NXqyWnJFOjSq Mny2bY5pcWKrdIOgVmFFODBzLXnu[JVk\WRiY3XscEBl\WG2aB?= NXfwWlB[OjN2Mk[4OVA>
astrocytes cell NWjSVm9pSXCxcITvd4l{KEG|c3H5 MoPyOFDPxE1? MXq2bC=> Mkm2doVlfWOnczDlZZJtgSCjcH;weI9{cXNiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5m MWWyN|QyOTd5OB?=
U-937 MWTBdI9xfG:|aYOgRZN{[Xl? MWGxNO69VQ>? NHLQN3I{OG2rbh?= MkC4dJJmfmWwdIOgWG5HNWmwZIXj[YQhdmWlcn;weI9{cXN? MnHmNlM1OTB5NEi=
MDA-MB-231 MlTWRZBweHSxc3nzJGF{e2G7 NIrkdXYyODEQvF2= M3Xqd|Fp M3KxXYlvcGmkaYTzJJNmdnOrdHn6ZZRqd25idH:gWHJCUUxidYDvckBOXESKIHTve44uemWpdXzheIlwdg>? M4fENVI{PDB6NEK5
HeLa  NEe3WpBCeG:ydH;zbZMhSXO|YYm= MVSxNFDPxE1? MWmybC=> NIPtW5VjdG:la4OgTnJUNTF3IFnu[JVk\XNiQYDvdJRwfGmlIFPlcIwhTGWjdHi= MnnyNlM{PDRyNEW=
Ec109 MmfURZBweHSxc3nzJGF{e2G7 NHHVb5MyOM7:TR?= Mm[4Oog> M3\ydoJtd2OtczDhdI9xfG:2aXOgZ49u[mmwYYTpc44hd2ZiVHH0MXNu[WOQNzDhcoQhemGmaXH0bY9v MUCyN|M{QDV4OB?=
H460  M364bmFxd3C2b4Ppd{BCe3OjeR?= NUfEclJrOTEQvF2= MofpOog> NHf1dJpjdG:la4OgZZBweHSxdHnjJINwdWKrbnH0bY9vKG:oIGTheE1UdWGlTkegZY5lKHKjZHnheIlwdg>? M4XXfFI{OzN6NU[4
HeLa  NIjOboRCeG:ydH;zbZMhSXO|YYm= Ml7xOVDPxE1? NX36WIIyOS53aB?= NX;OfoVE[WK{b3fheIV{yqCFaHzhcZllcWFvaX7keYNm\CCjcH;weI9{cXN? NGC2VVMzOzNyM{iwOC=>
SK-HEP1 NX7USmlXSXCxcITvd4l{KEG|c3H5 NES1R5AyODEQvF2= NX3q[3FJOWh? MlLTbY5pcWKrdIOgR5JVOSCjY4TpeoF1\WRiY3HzdIF{\S1|LDCtO{whNThuID25MEBidmRicH;sfUhCTFBvcnnic5NmMSCyb3z5cYVz[XOn M{WzelI{OzB{NkWw
QGY7701 NH;DN21CeG:ydH;zbZMhSXO|YYm= M2LT[VI2|ryP M13XOVEvPWh? MkXtbY5pcWKrdIOgZYNkfW23bHH0bY9vKG:oIIP1Zk1IOSCyaHHz[UBqdmS3Y3XkJIJ6KESRWDCrJJF2\XKlZYTpci=> MkLCNlMzPDByNkG=
HepG2 M1fLR2Fxd3C2b4Ppd{BCe3OjeR?= MoDRNlDPxE1? MUizNI1qdg>? M2S2[IlvcGmkaYTzJJRp\SCnbnjhcoNm\CClZXzsJIRm[XSqIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCjcHnn[Y5qdiCjbnSgWHJCUUx? NXzydpdjOjN{MkSyN|k>
U87  NWLSPZNPSXCxcITvd4l{KEG|c3H5 MVGyOe69VQ>? MoPMNog> NHnxW2pl\WO{ZXHz[ZMhcXOxbHnxeYlzcXSrZ3XubY4hMEmVTDmtbY5lfWOnZDDhdI9xfG:2aXOgZ4VtdCCmZXH0bEwh[nW2IH7veEBv\WO{b4TpZ{Bk\WyuIHTlZZRp NWC3O|A5OjN{Mkm2NlY>
HSC-2 MXTBdI9xfG:|aYOgRZN{[Xl? NX7JWGZmOjVxNUFOwG0> NEPicGUycA>? MlHVbY5pcWKrdIOgV24uOzhvaX7keYNm\CCleYTveI95cWOrdIm= MWeyN|E2PTJ2OB?=
HSC-4 NUX6UHY4SXCxcITvd4l{KEG|c3H5 NYjjPVBXOjVxNUFOwG0> Mmn2NYg> NWDYXVlncW6qaXLpeJMhW05vM{itbY5lfWOnZDDjfZRwfG:6aXPpeJk> NWjHTnBTOjNzNUWyOFg>
CL-1 NHm3SYFCeG:ydH;zbZMhSXO|YYm= MkfFNlDPxE1? NWfZcVd[OWh? NEf2UItjdG:la4OgU3A1PDliaX7keYNm\CClZXzsJIRm[XSq NHvt[JIzOzF|MUe4Ni=>
MEL NF\heFBCeG:ydH;zbZMhSXO|YYm= M4PKSVIx|ryP MYeyOIg> NITxRoJFVVOR M4L0NIlueGGrcnXzJHAzYDdvaX7keYNm\CCPRVygZ4VtdCCjcH;weI9{cXN? NILNS3czOzBzNEi4Oy=>
Bel-7402  NV;Y[IJZS2G|cHHz[UBC[3SrdnH0bY9vKEG|c3H5 NIXoS402OM7:TR?= M1ixSFJp NISycZRqdmirYnn0d{BRS0VvaX7keYNm\CCjbn;pb4l{ NGHZWYUzOzByOEe0Ni=>
Eca-109 Mn3HRZBweHSxc3nzJGF{e2G7 MVqyOe69VQ>? NXrZcmJ2OzCvaX6= M1;BeolvcGmkaYTzJGJLNUJzMT3pcoR2[2WmIHPlcIwh\GWjdHi= NUHqSJROOjNyN{[5Olc>
MEL NXHxNVhmSXCxcITvd4l{KEG|c3H5 M4nmbVIx|ryP NFm2[|EycA>? Mn7SSG1UVw>? MYnpcZBicXKnczDQNng4NWmwZIXj[YQhVUWOIHPlcIwh[XCxcITvd4l{ NVzw[oFQOjNyMUS4PFc>
Bel-7402  MXPBdI9xfG:|aYOgRZN{[Xl? NGi3TZE2OM7:TR?= NIPndJczcA>? M4nUfolvcGmkaYTzJHBETS2rbnT1Z4VlKGGwb3nrbZM> Ml3sNlMxODh5NEK=
L929 NEHiW4hHfW6ldHnvckBCe3OjeR?= NYW2W2dtOi53zszN NInh[2sycA>? MX;pcoNz\WG|ZYOgVmlROSCneIDy[ZN{cW:wIHHu[EBmgGGlZYLiZZRm\CCWTldOtU1qdmS3Y3XkJI1qfG:laH;u[JJq[WxiZInz[pVv[3Srb36gZY5lKFKRUzDwdo9lfWO2aX;u M1XHfFI{ODByNUG4
RCC  MoToR4VtdCCYaXHibYxqfHliQYPzZZk> MW[xNFDPxE1? M3;udVI1cA>? M3XTSpJm[2:4ZYLld{B1cGVidnnhZoltcXS7IH;mJINmdGy|IHX4dI9{\WRidH:gNVVlNVCJSkK= MorVNlI6QTF2OUS=
NB2a/d1 NVLMXXN5SXCxcITvd4l{KEG|c3H5 MWOxNFDPxE1? MmDMO|Jp M1;tToF1fGWwdXH0[ZMhe3SjdYLvd5BwemmwZT3pcoR2[2WmIHPhd5Bie2ViYXP0bZZqfHluIGDBVnAtKGGwZDD0ZZUh[2ynYY\h[4U> NW\EfWI3OjJ7OEi1OFE>
T cell NUHXfmdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3OfohxOjVvMUCw{txO M2r0O|I1cA>? M37EbIRwe2VvZHXw[Y5l\W62bImgbY5pcWKrdHXkJHQh[2WubDDwdo9tcW[ncnH0bY9vKG2nZHnheIVlKHSqcn;1[4ghfGinIHPvMZN1cW23bHH0bY9vKHerdHigZY51cS2FREOgZY5lKGGwdHmtR2QzQA>? Mm[5NlI6QDJ3M{i=
K562 Mn3uRZBweHSxc3nzJGF{e2G7 MoX4NVAx|ryP NUnLTXEyOWh? MkD3Zoxw[2u|IFHico9j[X[rc3P1ceKhTi2rbnT1Z4VlKGGyb4D0c5Nqew>? M4nGZVIzQTd{M{ey
Jurkat  M{L4NWFxd3C2b4Ppd{BCe3OjeR?= Mm\FOFDPxE1? NVzYO4xEOWh? NXLPNJc4[WKxbHnzbIV{KE[jc1ytbY5lfWOnZDDjZZNx[XOnIHHjeIl3[XSrb36gZY5lKGOnbHyg[IVifGh? NFLwOlEzOjl2MkezPC=>
BGC-823 MX\BdI9xfG:|aYOgRZN{[Xl? NEHCdlYyODEQvF2= Mn\uNYg> MWXwZZJ1cWGubImgdoV{[3WnczDj[YxteyCjZ3HpcpN1KGSjbXHn[UBw\iCmYXnkfoVqdg>? NF31PFYzOjl{NkW0OS=>
Hep3B MW\BdI9xfG:|aYOgRZN{[Xl? M{H1e|Ux|ryP NXTXOm5UOWh? NUOyPWp[[myxY3vzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEiHR1Pz Mn2xNlI6OjNzNUS=
LLC-PK1 MY\BdI9xfG:|aYOgRZN{[Xl? M{XkeVIx|ryP NEjGV5QycA>? MY\wdoV3\W62czDjbZNxdGG2aX6tbY5lfWOnZDDk[Ydz[WSjdHnvckBw\iCDdHe1MEBj\WOuaX6tNUwh[W6mIFH0[|EzKHC{b4TlbY5{ NXL4fYplOjJ6OU[wN|c>
A549 M{fpWmFxd3C2b4Ppd{BCe3OjeR?= M4X4elUx|ryP Mor4NYg> NFvnPJljdG:la4OgeIhmKEKDST3pcoR2[2WmIHHwc5B1d3Orc9Mg NVrJcXc6OjJ6OEeyNVU>
SGC-7901  NVvqfGN4SXCxcITvd4l{KEG|c3H5 NGHEN2gyOM7:TR?= NVrXeGZROjSq NE\OUGFqdmirYnn0d{DPui{Qsj3kbY1mfGi7bHHjdplte2ira3;ubY4ucW6mdXPl[EBieG:ydH;zbZPDqA>? NGHobHozOjh2OEW5Oy=>
DM6 MWLBdI9xfG:|aYOgRZN{[Xl? NYjGdGNrOTByzszN NYfVUY5NPzKq MYHicI9kc3NiYn;0bEBGOkZvMTDhcoQhTTKIdIKtcYVlcWG2ZXSgZ5l1d3SxeHnjbZR6 MkPLNlI5OjV|Mki=
MCF-7, MDA-MB-468, Caco-2 MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\MZlUx|ryP NYj5NmlIPDiq MYHpcohq[mm2czD0bIUh[2WubDDndo94fGhiaX7obYJqfGmxbjDpcoR2[2WmIHL5JJNieG:waX6= MnG0NlI5ODB7Nki=
A2750  MonaRZBweHSxc3nzJGF{e2G7 NXzE[oNIOjEQvF2= NWj2PXdOOmh? Mnm3SG1UVw>? M{XMOYJtd2OtczDjZZNx[XOnIHPs[YF3[WenIHT1dolv\yCqZXzlcoFtcW5idILlZZRu\W62IHHu[EBz\WS3Y3XzJIF2fG:yaHHnbYMh[2WubDDk[YF1cA>? NUHWVXF[OjJ5OESzOlM>
U87  Mn23RZBweHSxc3nzJGF{e2G7 NXe0enJrOjEQvF2= NEnHOlczPGh? MlnsdoVlfWOnczD0bIUh[XCxcITvd4l{KHKjdHWgbY5lfWOnZDDifUBRVEGE M2\ncVIzPzd6N{iw
HT1080 NFLuSXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfoNINQPTEQvF2= NXO0TpRlP2R? Mk\kbY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHnubIljcXSrb36gZ4F2e2WmIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCGQ1GgZY5lKE:PUB?= NUDz[IFrOjJ5NEC5PFQ>
A549  MYXBdI9xfG:|aYOgRZN{[Xl? NIH3RoI2OM7:TR?= MojDNog> M2HxfpBienSrYXzsfUBl\WO{ZXHz[ZMhe2:maYXtJJNmdGWwaYTlMYlv\HWlZXSgZZBweHSxc3nz NHuxNJgzOjd{MUiwOC=>
Primary OPC MXnBdI9xfG:|aYOgRZN{[Xl? Mo\lNe69VQ>? NXnnXVN5PmhxMkTo NVHRUFhiemWmdXPld{B1cGVicHXyZ4VvfGGpZTDv[kBk\WyuczDpckBm[XKueT2gZY5lKGyjdHWtZZBweHSxc3nzM45m[3Kxc3nz NGG4NIYzOjdyN{O4OS=>
PMNs MkC4RZBweHSxc3nzJGF{e2G7 NEXTPWc1OM7:TR?= MUe2bC=> Mnf2SG1UVw>? M1vP[ZJmfmW{c3XkJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CClYYPwZZNmNTNidH:gcoVieiC4ZXjpZ4xmKGyndnXsdy=> M{CweVIzPjl{NUe3
A549  MUPBdI9xfG:|aYOgRZN{[Xl? NYDDPW9NPTEQvF2= NFHNNFUycA>? NW\3b5VSeHKndnXueJMh[XCxcITvd4l{KGmwZIXj[YQh[nliQnHvbJVwe2mmZTDJ M2\JTVIzPjh5NkO1
AGS MVXBdI9xfG:|aYOgRZN{[Xl? Ml2yNlDPxE1? MkPhNVJp NIDWSXFqdmirYnn0d{B1cGViYXP0bZZifGmxbjDv[kBxem9vY3HzdIF{\S1|IHnuJJJme3CxboPlJJRwKHSqZTDFeG9C[yCocnHjeIlwdg>? NVzKUVdjOjJ4OEezPVg>
shC9  M2r2[WFxd3C2b4Ppd{BCe3OjeR?= MYOxNO69VQ>? MXyxOog> NH30ZmpjdHWwdIOgV2hJKGW6cILld5Nqd25iaX6gd4hEQSClZXzsd{BmgHCxc3XkJJRwKGWrdHjldkBRSSCxcjDMVGM> MXmyNlY1OTB7NB?=
primary MEFs MnfhSpVv[3Srb36gRZN{[Xl? MVSxNog> Mn;jxsBqdmO{ZXHz[ZMh\XSxcH;zbYRmNWmwZIXj[YQhdWm2b3Poc45lemmjbDDt[Y1jemGwZTDk[ZBwdGG{aYrheIlwdg>? NHjyclEzOjZzM{e2Oy=>
3T9 MEFs MUnGeY5kfGmxbjDBd5NigQ>? MnTwNVZp M1:4b4lv[3KnYYPld{BkgXSxY3jyc41mKGNicnXs[YF{\SCjZoTldkBmfG:yb4Pp[IUufHKnYYTt[Y51 Mme5NlI3OTN5Nke=
3T9 MEFs MlPoSpVv[3Srb36gRZN{[Xl? MXmxPIg> MYj1dJJm\3WuYYTld{Bqdmm2aXH0c5Ih[2G|cHHz[U06KGK3dDDkc5dvemWpdXzheIV{KGWoZnXjeI9zKGOjc4Dhd4V{KGGodHXyJIV1d3Cxc3nk[UB1emWjdH3lcpQ> M37GPVIzPjF|N{[3
MDA-MB-231  M3TlPGFxd3C2b4Ppd{BCe3OjeR?= NEO4ZpYzOM7:TR?= MVK0[C=> M3q4TZJm\HWlZYOgeIhmKGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhdWW2Zn;ycYlvKHS{ZXH0cYVvfCC5YYOgd4lodmmoaXPhcpRtgQ>? NX;jfoZQOjJ3OUO0OFE>
C6  NGrrO5hCeG:ydH;zbZMhSXO|YYm= NV;XfFk4OTEQvF2= NVPPfldUOjSq MlriZoxw[2u|IITo[UB{fXCycnXzd4l3\SCnZn\lZ5Qhd2ZidHjlJJBmeHSrZHWgc44hfmmjYnnsbZR6 NX\IcnM{OjJ3OEi5PFA>
HL-60  MWXBdI9xfG:|aYOgRZN{[Xl? NGWxWVgyODEQvF2= NYTpe4lKOjSq NXfDVnl7cW6qaXLpeJMhfGinIHPlcIwh[XCxcITvd4l{KHOnbHXjeIVlKChtKT3t[Y51cHmuIN8yMUgy6obUNjmt[IlodHWlb4D5doFvd3OrZHZCpFU> MVWyNlU1PjZ4OR?=
HL-60 NInrSWhCeG:ydH;zbZMhSXO|YYm= MmTMNVAuQDEQvF2= MXS0bC=> NV2yUplGcW6qaXLpeJMhXEeKUT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{yqB? MXqyNlUzOzJ{OR?=
BCC MVnBdI9xfG:|aYOgRZN{[Xl? NF74NY42OM7:TR?= MojjNYg> NXXkO4ZGcW6qaXLpeJMhTEGWUz3t[YRq[XSnZDDndo94fGhiaX7obYJqfGmxbh?= Mnr0NlI2OTl2M{[=
RAW 264.7 MnrXRZBweHSxc3nzJGF{e2G7 NXnucHJ4PTBxMUCw{txO NGLM[mEycA>? MXXjc45k\W62cnH0bY9vNWSncHXu[IVvfCCrbnjpZol1eyCGT16tbY5lfWOnZDDyVm5CKGOuZXH2ZYdm MnLxNlI1QTF2Mk[=
K562 NUTBd|ZLSXCxcITvd4l{KEG|c3H5 MkXvNlXPxE1? NIPCfoQzcA>? NFL4WJNxemW4ZX70d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClbz30doVifG2nboSge4l1cCCjbYXy[Y5{cW5iRzDhcoQhXFKDSVy= NVHmVnF4OjJ2OEO3O|c>
SGC-7901 MljYRZBweHSxc3nzJGF{e2G7 NUDacJZUOjBizszNxsA> NFzxZ5UzcA>? NWrGfWdj[XS2ZX71ZZRmeyCKMl:yxsBweiCWTl[g{tEucW6mdXPl[EBk\WyuIHHwc5B1d3OrczDhd{B4\WyuIHHzJINie3Cjc3WtN{Bi[3Srdnn0feKh NX\ZT3JKOjJ2N{G1PFk>
PC3 MXvBdI9xfG:|aYOgRZN{[Xl? NIn5R5cyOM7:TR?= NHfMWVM1cA>? NEPqdI9kd3WwdHXyd{BndGG4b3PvfIllNWmwZIXj[YQh[2G|cHHz[U1z\WyjdHXkJIFxd3C2b4Ppdy=> MVeyNlQ4OTl5NB?=
SMMC-7721 MYLBdI9xfG:|aYOgRZN{[Xl? MUK1NO69VQ>? MVq0PIg> MVrheJRmdnWjdHXzJI9VWi2rbnT1Z4VlKGGyb4D0c5Nqew>? M3rzXFIzPDZ3OEOz
HeLa  MlrHRZBweHSxc3nzJGF{e2G7 NXL4ZXpxPTEEoN88US=> MXi0M|hp MmnubY5pcWKrdIOgV3RUNWmwZIXj[YQhdGG2ZT3wbIF{\SCjcH;weI91cWNiZY\lcpR{ M1S4WFIzPDZyNUC0
HeLa  M1\rV2Fxd3C2b4Ppd{BCe3OjeR?= M{PmTVUxyqEQvF2= MUOxbC=> NVjTRVhIe3WycILld5NmeyC2aHWgSnJCWC2rbnT1Z4VlKGGlY4XteYxifGmxbjDv[kBidm6neHnuJHYheG:|aYTpeoUh[2WubIO= NWq3dVVnOjJ2NEm0OFA>
T47D  MkXkRZBweHSxc3nzJGF{e2G7 NGP5[3AyODEQvF2= MX6xbC=> MU\icI9kc3NidHjlJIdmdmW{YYTpc44hd2ZiRT3jZYQwS1SIMjDifUBUXFN? NV61[GhEOjJ2MEGxOlg>
HeLa  M{XCW2Fxd3C2b4Ppd{BCe3OjeR?= MojwN|DPxE1? MYm0bC=> M4\mRuKhcW6lcnXhd4V{KHSqZTDn[Y5memGuIHPlcIwhfmmjYnnsbZR6KDR6IHigZYZ1\XJicHjveI9lgW6jbXnjJJRz\WG2bXXueOKh NFvhRoszOjN7NEK0PC=>
HCC MkfORZBweHSxc3nzJGF{e2G7 M1nnN|IxKM7:TdMg NXT0VJlIOmh? M{fIWYF1fGWwdXH0[ZMhfGinIFTIRUBqdmS3Y3XkJIFkfGm4YYTpc44hd2ZiUFHSVC=> MluwNlI{PDJ5M{K=
mESCs NVrHfmcxSXCxcITvd4l{KEG|c3H5 NWfJRZRuOi53zszN MX2ybC=> NYXPbJo1cW6qaXLpeJMhfGinIF7hSk1u\WSrYYTl[EBk[XOyYYPlJIFkfGm4YYTpc44> MoOzNlIzQDV{N{S=
EMT-6  NGLYOWVEgXSxdH;4bYNqfHliQYPzZZk> M4LDflExOM7:TR?= M3Kwc|Fp Ml;qdIFzfGmjbHz5JIJtd2OtZXSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KHOrcnHt[ZNqdmV? M2PyUVIzOjVzOUKx
MCF7 M1nBTmFxd3C2b4Ppd{BCe3OjeR?= MlLtOVDDqM7:TR?= M2PtSFFp MYjpcohq[mm2czDQRUBi[3SrdnH0[YQh[2G|cHHz[U0{NCBvOTygZY5lKHCxbImoRWRRNXKrYn;z[UkheG:ueX3ldoF{\Q>? NVTxXlJ1OjJ{MkOzOFU>
K562 MX\BdI9xfG:|aYOgRZN{[Xl? MVGyNEDPxE4EoB?= NGTieoQ1QGh? M3f0UmROW09? NXe5b4hx[myxY3vzJIxieGG2aX7pZk1qdmS3Y3XkJIlvcGmkaYTpc44hd2ZidnnhZoltcXS7IHHu[EBieG:ydH;zbZMhcW6mdXP0bY9v MVOyNlIyPjF3OB?=
Molt4-hyg MYrBdI9xfG:|aYOgRZN{[Xl? MoO5NVDPxE1? NVPmb4ZDOC53aB?= NX7lVnNI[myxY3vzJIZiem6nc3;sMYlv\HWlZXSgZ4F{eGG|ZT2zMYxqc2ViYXP0bZZqfHl? MY[yOlI4PThzMR?=
HeLa M{PvdGFxd3C2b4Ppd{BCe3OjeR?= NVzIZ|JvOTEQvF2= NHLwPFQxNjWq MmrIbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhfGinIHPvcYJqdmWmIITy[YF1dWWwdDD3bZRpKGexbXnzbY4hViCjbnSgWHJCUUx? MnvMNlIyPzl4NkG=
Jurkat T M2fI[mFxd3C2b4Ppd{BCe3OjeR?= NH21WFE{OM7:TR?= MmS5NE42cA>? NH:2UFBFVVOR NF\6SldjdG:la4OgeIhmKHqrcnHtMYlv\HWlZXSgZZBweHSxc3nz MlXINlIyPTl6OUi=
Neutrophil NVviVGtYSXCxcITvd4l{KEG|c3H5 NVv5PYpyOjEQvF2= MXmwMlVp NWrG[ZBs[XS2ZX71ZZRmeyC2aHWgdJJwNWGyb4D0c5Rq[yCnZn\lZ5Qhd2ZiTXHSNS=> NUDscWU3OjZzOU[4OFQ>
HCT116 NHXkNZVCeG:ydH;zbZMhSXO|YYm= NXSyXo1qPTEEoN88US=> NYm5VJVsOmh? NIC2c2lz\X[ncoPld{B{gW6ncnfpd5Rq[yCjcH;weI9{cXNiZX\m[YN1eyCxZjDj[Yxm[2:6aXKgZY5lKE6SQz2xOuKh MUCyNlE2QTd3Mh?=
MDA-MB-231  M3fIbmFxd3C2b4Ppd{BCe3OjeR?= Mn7lNk42NTdwNd88US=> MVWybC=> NFO5WHFqdmirYnn0d{B1cGViY3XscEBl\WG2aDDv[kBOTEFvTVKtNlMyKGOnbHzzJIlv\HWlZXSgZpkhW0SWIHnuJIEh[2:wY3XueJJifGmxbjDk[ZBmdmSnboSgcYFvdmW{ M3\0XVIzOTF3NUK2
LNCaP NYP0eHpNSXCxcITvd4l{KEG|c3H5 NGK2[G01OM7:TR?= MnH5Nog> NYXUcmhJcW6qaXLpeJMh[nW2ZXnuJIlv\HWlZXSgZ4VtdCCjcH;weI9{cXN? M3n4fFIzOTF2N{[0
MB231 MYnBdI9xfG:|aYOgRZN{[Xl? MWexNFDPxE1? NYfzeXZMOWh? M3;1dWROW09? MYrhZpJw\2G2ZYOgeIhmKGmwZIXjeIlwdiCxZjDj[YxtKGSnYYToJIJ6KFeHRUGgbY5pcWKrdHnvckwhXFKDSVygeJJm[XSvZX70MEBidmRidHjlJINwdWKrbnH0bY9v NID1bWUzOjFzMkm0NC=>
HCC38  NX\t[3NNSXCxcITvd4l{KEG|c3H5 MWGxNFDPxE1? MXOxbC=> Mn3CSG1UVw>? NEi2ZXFi[nKxZ3H0[ZMhfGinIHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGK7IGfFSVEhcW6qaXLpeIlwdixiVGLBTWwhfHKnYYTt[Y51NCCjbnSgeIhmKGOxbXLpcoF1cW:w NHO1PHAzOjFzMkm0NC=>
MDA-MB231 M2WxfGFxd3C2b4Ppd{BCe3OjeR?= MUS1NOKh|ryP NFH0doszPGh? NV\PO3hlTE2VTx?= M{jBeIFjem:pYYTld{BkfXKldX3pck1qdmS3Y3XkJINmdGxiZHXheIg> M3r3c|IzOTBzM{O1
LNCaP NIfrSZRCeG:ydH;zbZMhSXO|YYm= M1nWcVUxyqEQvF2= NXS3WlE3OjSq NFn5cIRFVVOR NEG2UZRi[nKxZ3H0[ZMh[3W{Y4XtbY4ucW6mdXPl[EBk\WyuIHTlZZRp MlTzNlIyODF|M{W=
HCT116 Mmr4RZBweHSxc3nzJGF{e2G7 NUD1cVJbPTEEoN88US=> MYCyOIg> MVLEUXNQ MnPTZYJzd2ejdHXzJIN2emO3bXnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MlnGNlIyODF|M{W=
Ishikawa  Mnj1RZBweHSxc3nzJGF{e2G7 MWeyOe69VQ>? MYqyOIg> MUDy[YR2[2W|IHPlcIwh\GWjdHigZY5lKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IFLh[kBCOQ>? NWLJV49XOjJyOEi5NVg>
 YD-8  MkP1RZBweHSxc3nzJGF{e2G7 NYXzdFJkOTByzszN NVHPN5BOOWh? MWXpcohq[mm2czDQUGVQNWmwZIXj[YQh[XCxcITvd4l{ MVKyNlA5PjF6Mx?=
eosinophil  MmPvRZBweHSxc3nzJGF{e2G7 MV[5NO69VQ>? NIWyNGszPGh? NXfWVnNGcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliRnHzJIFvfGmkb3T5xsA> NVX1UndoOjJyN{mzN|Q>
L929 NEXpdGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVf1PINFOi53zszN Mn[0NlRp M1vSV4lvcGmkaYTzJJRp\SCneIDy[ZN{cW:wIH;mJJAueDN6IHHu[EBPTi4QulKgeI8h[XWpbXXueEBVVkcQsT3pcoR2[2WmIH7lZ5JweHSxc3nzJIFv\CCjdYTvdIhi\3l? M33LXVIzODJ5MEm3
YD-8  MXnBdI9xfG:|aYOgRZN{[Xl? NX;3RVduOTByzszN MVGxbC=> Mn;MZoxw[2u|IITo[UBIWy2KQ3ytbY5lfWOnZDDhdI9xfG:|aYO= MnLZNlIxOjByN{i=
HBx MVvBdI9xfG:|aYOgRZN{[Xl? NE\B[HczPc7:TR?= MmTEOFhp M3PaWWROW09? MneydoVlfWOnZDDj[YxtKGSnYYToJIlv\HWlZXSgZpkhOy2PQR?= NUezb251OjJyMkCwO|g>
U937  MonrRZBweHSxc3nzJGF{e2G7 NYrxT3RXPTEEoN88US=> NXzyWVIyOWh? M3;xOIlvcGmkaYTzJGhHNWmwZIXj[YQh[XCxcITvd4l{yqB? NYnjcXhROjF7OUi3N|E>
HL60 MonqRZBweHSxc3nzJGF{e2G7 NVnhflF{PDEQvF2= MUW0NI1qdg>? M2nKTWROW09? NEDyXWtjdG:la4OgRm5FSyClb33wc5Vv\HNiaX7keYNmKGW6cH;zeZJmKG:oIIDoc5NxcGG2aXT5cJNmemmwZTDhcoQhTE6DIH\yZYdu\W62YYTpc44> MYeyNVk5OzJ7Nh?=
M-14 MUTBdI9xfG:|aYOgRZN{[Xl? MX:yOe69VQ>? NF;GfWUxNjWq MlrFxsBqdmirYnn0d{Bjd3SqIITo[UBkenWmZTDlfJRz[WO2LTDhcoQh[2:vcH;1coQucW6mdXPl[EBieG:ydH;zbZM> NIHHdW8zOTl3NEm1PS=>
SK-BR-3 NWThSZkxSXCxcITvd4l{KEG|c3H5 M1zObVUxyqEQvF2= M{D4[FJp M1y0O4Jtd2OtczDhdI9xfG:2aXOgSG5CKG[{YXft[Y51[XSrb36gbY5lfWOnZDDifUBkd22kaX7heIlwdiCxZjDTUU0yPjRiYX7kJJJi\GmjdHnvci=> Mk\PNlE6ODF|OE[=
MDA-MB-468 MVfBdI9xfG:|aYOgRZN{[Xl? MV21NOKh|ryP M1uzPVJp MWricI9kc3NiYYDvdJRwfGmlIFTORUBnemGpbXXueIF1cW:wIHnu[JVk\WRiYomgZ49u[mmwYYTpc44hd2ZiU12tNVY1KGGwZDDyZYRq[XSrb36= MXyyNVkxOTN6Nh?=

... Click to View More Cell Line Experimental Data

体内研究 有研究表明,体内Z-VAD-FMK的给药不具有毒性,在动物模型中可抑制凋亡。在小鼠中,腹腔注射HK-GBS可引起早产,而预处理以Z-VAD-FMK可延迟早产现象。在OVA-sensitized的小鼠中,z-VAD-fmk的处理可抑制过敏原诱导的白细胞浸润。在OVA致敏前全身性注射z-VAD-fmk可减少OVA-sensitized/challenged小鼠中炎性细胞的积累、黏液的高分泌以及Th2细胞因子的释放。处理以z-VAD-fmk可阻止晶状体上皮细胞、角质细胞的终末分化;单核细胞向巨噬细胞的分化;以及红系造血祖细胞的分化。z-VAD-fmk可减缓过敏原诱导的呼吸道炎症以及高敏性、阻止后续T细胞的激活[7]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[6]

+ 展开
  • Cell lines: 颗粒细胞GC1a, HGL5, COV434
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    为了确定Z-VAD-FMK的效力,在常氧条件下,用etoposide (50 μg/ml) 和/或 Z-VAD-FMK (50 μM)对三种人源颗粒细胞系(GC1a, HGL5, COV434)进行处理,处理48小时。为了模拟卵巢片段抑制后的缺氧状态,用低氧(1% O2)状态下,用无血清培养基培养细胞,处理以Z-VAD-FMK。用WST-1试验检测细胞的代谢活性。通过FACS检测细胞活力,RT-qPCR和WB检测凋亡相关分子的表达。


    (Only for Reference)
动物实验:

[7]

+ 展开
  • Animal Models: CD1小鼠
  • Formulation: 溶解于DMSO,用PBS进行稀释,最终DMSO浓度小于1%
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

溶解度 (25°C)

化学数据

分子量 467.49
化学式

C22H30FN3O7

CAS号 187389-52-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    Can you suggest an in vivo formulation of S7023 for animal studies?

  • 回答:

    For in vivo study of S7023, The IP formulation is 2% DMSO+35 % PEG 300+2% Tween 80+ddH2O up to 6 mg/ml. The gavage formula is 1%CMC-Na up to 30 mg/ml (suspensions).

  • 问题 2:

    What is difference between S7023 & S8102?

  • 回答:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID