FXR

  • 抑制剂选择性比较
  • 溶解性比较
目录号 产品目录 溶解度(25°C)
DMSO 酒精
S3736 Fondaparinux Sodium 100 mg/mL 1 mg/mL <1 mg/mL
S3792 Guggulsterone E&Z -1 mg/mL 62 mg/mL -1 mg/mL
S2782 GW4064 <1 mg/mL 100 mg/mL <1 mg/mL
S2694 Turofexorate Isopropyl (XL335) <1 mg/mL 33 mg/mL 2 mg/mL
S1843 Chenodeoxycholic Acid <1 mg/mL 79 mg/mL 79 mg/mL
S4003 Lithocholic acid <1 mg/mL 75 mg/mL 47 mg/mL
S8733 Tropifexor (LJN452) <1 mg/mL 100 mg/mL <1 mg/mL
S7660 Obeticholic Acid <1 mg/mL 84 mg/mL 84 mg/mL
产品目录 产品描述 文献引用 实验数据
S3736New

Fondaparinux Sodium

Fondaparinux是一种合成的喃葡萄糖,具有抗血栓形成的活性。它能选择性地结合抗凝血酶 III,从而加强对活化Factor Xa的中和。它是Factor Xa的合成型抑制剂。

S3792New

Guggulsterone E&Z

Guggulsterone is one of the active constituent of Commiphora mukul. It occurs in two isomeric forms, namely Z-GS and E-GS. Guggulsterone act as antagonist ligands for the bile acid receptor, farnesoid X receptor, and as active ingredients responsible for the hypolipidemic activity.

S2782

GW4064

GW4064是一种farnesoid X receptor (FXR)激动剂,CV1细胞系中EC50为65 nM。浓度达到1 μM时,对其他核受体没有活性。

S2694

Turofexorate Isopropyl (XL335)

Turofexorate Isopropyl (XL335)是一种有效的,选择性的FXR激动剂,EC50为4 nM,高选择性作用于其他核受体,如LXR, PPAR, ER等,Phase 1。

S1843

Chenodeoxycholic Acid

Chenodeoxycholic acid 是一种天然存在的人体胆汁酸。

S4003

Lithocholic acid

Lithocholic acid是一种胆汁酸,可以溶解脂肪用于吸收。

S8733New

Tropifexor (LJN452)

Tropifexor (LJN452) is a novel and highly potent agonist of FXR with EC50 of 0.2 nM in HTRF assay. It shows no significant off-target activity against a broad panel of enzyme, ion channel, nuclear receptor, and GPCR (>10000-fold selectivity for FXR).

S7660

Obeticholic Acid

Obeticholic Acid是一种有效的选择性farnesoid X receptor (FXR)兴奋剂,EC50为99 nM。Phase 3。