Pictilisib (GDC-0941)

目录号:S1065 别名: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂,在无细胞试验中IC50为 3 nM,对p110β (11倍)和p110γ (25倍)具有适度的选择性。Phase 2。

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RMB 1972.48 现货
RMB 986.88 现货
RMB 1390.74 现货
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RMB 7926.11 现货
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客户购买Selleck的此次产品后发表的文献59篇:

客户使用该产品的9个实验数据:

  • Clonogenic assays of TNBC cell lines grown continuously in increasing concentrations of palbociclib, divided by gene expression subtypes: LAR, luminal androgen receptor; MSL, mesenchymal stem-like; MES, mesenchymal and basal-like. All cell lines are RB1 wild-type except RB1 mutant BT549.

    Clin Cancer Res, 2017, 23(18):5561-5572. Pictilisib (GDC-0941) purchased from Selleck.

    Dual PI3K/BRAF inhibition upregulates BIM and enhances apoptosis in PTEN cells. A, left, Western blot of 1205Lu cells treated with PLX4720 (3 μmol/L, 48 hours), the PI3K inhibitor GDC-0941 (3 μmol/L, 48 hours), or both drugs in combination (PtG); right, immunofluorescence staining of BIM (green) and DAPI (blue) in PTEN cells following PLX4720 treatment (3 μmol/L, 48 hours), the PI3K inhibitor LY294002 (10 μmol/L, 48 hours), or both drugs in combination (PLXtLY). B, left, immunofluorescence staining of PTEN 1205Lu following combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48hours) increases nuclear localization of FOXO3a (green). DAPI is shown in blue. Magnification 40. Right, combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48 hours) increases PTEN WM793 BIM mRNA levels to those observed with single BRAF inhibition (3 μmol/L PLX4720, 48 hours) in the PTENt WM35. C, PTEN cells were treated with PLX4720 (3 μmol/L, 48 hours), GDC-0941 (3 μmol/L, 48hours), or a combination of the 2 drugs (3Pt3G) before Annexin-V staining was analyzed by flow cytometry (*, P < 0.05 between the drug combination and each inhibitor alone). D, combined BRAF/PI3K inhibitor treatment blocks the escape of 1205Lu cells (PTEN) from therapy. Spheroids of 1205Lu cells were treated with either PLX4720 alone (3 and 10 μmol/L: data shows 3 mmol/L), LY294002 (10 μmol/L) alone or a combination of the 2 drugs for 72 hours. In other studies, spheroids were treated with drugs for 72 hours and then allowed to recover for 120 hours. Micrograph shows viability staining (green= live cells, red= dead cells). Magnification 10×.

    Cancer Res 2011 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck.

  • Combination of rapamycin and PI-103 leads to the suppression of AKT phosphorylation (phospho-specific western blot). Mel-Juso and 518A2 cells were treated with GDC-0941 from 0.05–1 μmol/L alone and in combination with rapamycin (50 nmol/L) for 24 hours. Control treatment was with DMSO.

     

     

    J Inves Der 2010 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck.

    Growth inhibition induced by the FGFR inhibitor BGJ398 and the PI3K inhibitors alone or in combination. AN3CA (A-C), JHUEM2 (D-F) and MFE296 (G-I) cells were treated with the indicated doses of BGJ398, GDC-0941 a n d BYL719 alone or in combination for 96 hours and an Sulforhodamine B (SRB) assay was subsequently performed. Data are presented as a percentage of the control, in which cells were treated with 0.1% (v/v) DMSO. Points represent the mean of three independent experiments (each performed in triplicate). Error bars represent the standard error of the mean (SEM) and lines were fitted using non-linear regression analysis. Interaction of BGJ398 and GDC-0941(redcircles) or BYL719(blacksquares) in AN3CA(C), JHUEM2(F) and MFE296(I). Median effect analysis was used to evaluate the interaction between the inhibitor combinations. Horizontal dotted lines indicate the boundaries for each interaction classification.

    Mol Cancer Ther, 2017.. Pictilisib (GDC-0941) purchased from Selleck.

  • TGF-β induces mTORC2 activation. ( A ) NMuMG cells were treated with TGF-β for the indicated times before lysis and immunoblotting. (B ) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to anti-Rictor immunoprecipitation, and the immunoprecipitates were subjected to in vitro kinase assays using kinase-inactive Akt1 as a substrate, before immunoblotting of the kinase reactions, immunoprecipitates and cell lysates. The left panels are from the same gel, without differential exposure. ( C ) NMuMG cells were treated or not with TGF-β or insulin for the indicated times, in the presence or absence of SB431542 or GDC-0941. The kinase activity of mTORC2 was then assessed as in B. The top panels are from the same gel, without differential exposure. (D) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to immunoprecipitation using Rictor antibody, and/or immunoblotted.

    J Cell Sci 2012 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of GDC-0941  for 3h,followed by 15-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck.

  • We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.

     

     

    Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck.

    Effects of LY294002 and GDC-0941 on the high-glucose-induced plasma membrane translocation of DGK δ1. (A, C) HEK293 cells were transfected with pAcGFP-DGKδ1 or pAcGFP-C1 vector. After being glucose-starved for 2.5 h and the subsequent pretreatment with (A) 10 μM LY294002 (Sigma-Aldrich) or (C) 1 μM GDC-0941 (Selleck Chemicals) for 30 min, the cells were incubated with or without high glucose (25 mM) for 5 min. The cells were fixed with 3.7% formaldehyde and observed using confocal laser-scanning microscopy. Scale bar = 10 μm. (B, D) After treatment with (B) LY294002 or (D) GDC-0941, the percentages of cells exhibiting the translocation of AcGFP-tagged DGK δ 1 to the plasma membrane were scored. More than 20 cells ex-pressing AcGFP-tagged DGK δ1 were counted in each experiment. The results are the means ± S.D. of three independent experiments. The statistical significance was deter-mined using Student's t -test (** P < 0.01, *** P < 0.005)

    Biochim Biophys Acta 2012 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck.

  •  

    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    Pictilisib (GDC-0941) purchased from Selleck.

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂,在无细胞试验中IC50为 3 nM,对p110β (11倍)和p110γ (25倍)具有适度的选择性。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
体外研究

GDC-0941也等效作用于PI3Kα和 PI3Kδ和PI3Kα突变型E545-K和H1047-R,也选择性作用于PI3Kβ(10倍)和 PI3Kγ(25倍), 选择性更高地作用于PI3K II, III, 和IV类成员,包括, C2β, Vps34, DNA-PK和mTOR。GDC-0941 作用于U87MG, PC3, 和 MDA-MB-361 细胞,有效抑制Akt磷酸化,IC50分别为46 nM, 37 nM,和 28 nM。GDC-0941抑制U87MG, A2780, PC3, 和MDA-MB-361细胞增殖,IC50分别为 0.95 μM, 0.14 μM, 0.28 μM, 和0.72 μM。[1]GDC-0941处理,有效抑制对Trastuzumab敏感和不敏感的HER2扩增细胞增殖,IC50为149-944 nM,与 Trastuzumab敏感性无关。GDC-0941抑制含PIK3CA突变的HER2扩增的细胞增殖,IC50<500 nM, 且有效抑制抗trastuzumab 的HER2 扩增乳腺癌细胞增殖和活力。[2]GDC-0941 显著抑制HCT116, DLD1和 HT29细胞生长,GI50分别为1081 nM, 1070 nM 和157 nM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 NGjU[oxMcW6jc3WgRZN{[Xl? Moe0NUBp NV31TYx3TE2VTx?= NF\4UXlKdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHTlcJRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlAxOyEQvF2= M3z4VFE5PzV2NkW0
Sf9 MnHJT4lv[XOnIFHzd4F6 NHXae4UyKGh? MXTEUXNQ MWfJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgTFExPDdvUjDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> NV;4SoNoOTh5NUS2OVQ>
Sf9 M2Dy[2tqdmG|ZTDBd5NigQ>? M1i1bVEhcA>? MmDHSG1UVw>? M3\1eWlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBGPTR3LVugcZV1[W62IHX4dJJme3OnZDDpckBU\jliY3XscJMh[2:neIDy[ZN{cW6pIIC4OYFteGijIIfpeIghUUN3MDDv[kAxNjByMzFOwG0> MljwNVg4PTR4NUS=
Sf9 MnrRT4lv[XOnIFHzd4F6 NHe0N|cyKGh? M{fXdWROW09? NXvodXdNUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDi[ZRiKGW6cILld5Nm\CCrbjDT[lkh[2WubIOgZ49mgHC{ZYPzbY5oKHB6NXHsdIhiKHerdHigTWM2OCCxZjCwMlA{OyEQvF2= NIm1SnkyQDd3NE[1OC=>
Sf9 MX3LbY5ie2ViQYPzZZk> NFX3d3YyKGh? NFrNUZFFVVOR M4WxWGlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYXzwbIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIE> M1PNd|E5PzV2NkW0
MDA-MB-361 M2n5SmZ2dmO2aX;uJGF{e2G7 M1rMblIhcA>? MVrEUXNQ NUX2[mpOUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBpfW2jbjDNSGEuVUJvM{[xJINmdGy|IIfpeIghWEmNM1PBJGU2PDVvSzDteZRifGmxbjD3bZRpKEmFNUCgc4YhOC5yMkig{txO NFzQNHgyQDd3NE[1OC=>
PC3 M1jBUWZ2dmO2aX;uJGF{e2G7 NV\DW4ZxOiCq NGHmd5pFVVOR NGLOUY9KdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJHBVTU5vboXscEBpfW2jbjDQR|Mh[2WubIOge4l1cCCLQ{WwJI9nKDBwMEO3JO69VQ>? MmjKNVg4PTR4NUS=
U87MG MkXqSpVv[3Srb36gRZN{[Xl? MYWyJIg> MXfEUXNQ M3;ZdmlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25iaX6gVHRGVi2wdXzsJIh2dWGwIGW4O21IKGOnbHzzJJdqfGhiSVO1NEBw\iByLkC0OkDPxE1? NYnneHFFOTh5NUS2OVQ>
MDA-MB-361 NYHMOm1HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYi5OkBp NVuxZ4dNTE2VTx?= M4H6bmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTN4MTDj[YxteyC5aYToJHBKUzOFQTDFOVQ2NUtibYX0ZZRqd25id3n0bEBKSzVyIH;mJFAvPzJizszN Mnj2NVg4PTR4NUS=
A2780 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DafFk3KGh? M1HoVmROW09? NFjxUIdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFGyO|gxKGOnbHzzJJdqfGhiUFnLN2NCKGGwZDDQWGVPKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlE1KM7:TR?= MXKxPFc2PDZ3NB?=
PC3 M{flXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvUPVYhcA>? NWWyOYpJTE2VTx?= Ml6xTWM2OD1yLkK4JO69VQ>? MXWxPFc2PDZ3NB?=
U87MG NEPQOVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\aU4JuQTZiaB?= NWi0fJRsTE2VTx?= MYPJR|UxRTBwOUWg{txO NEGxS3QyQDd3NE[1OC=>
Sf9 NX3QUWp4U2mwYYPlJGF{e2G7 M1LXfVMxKG2rbh?= NHXq[pdFVVOR MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiYX3veY51KG:oIFHUVEBkd26|dX3l[EB4cXSqIFnDOVAhd2ZiMD6wOFIh|ryP NWTKbY9jOjJ3NEizOFI>
RAW 264.7 NF\ueJZMcW6jc3WgRZN{[Xl? NF\3Ong6OCCvaX6= M3HjVmROW09? MYTJcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBCU1RicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlI6QCEQvF2= NGLoTmczOjV2OEO0Ni=>
Sf9 M3[1emtqdmG|ZTDBd5NigQ>? MnXyNUBp Mli4TY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4JmfGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKFOIOTDj[YxteyC5aYToJGlEPTBib3[gNE4xOTdizszN NVfHO3VnOjN3NEC2OFU>
Sf9 NH\UfYdMcW6jc3WgRZN{[Xl? M1ryPFEhcA>? MX;Jcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPL[IVtfGFiZYjwdoV{e2Wm NXTSU|llOjN3NEC2OFU>
Sf9 M3T6fWtqdmG|ZTDBd5NigQ>? NIjK[2YyKGh? M4LYPGlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2to[W2vYTDlfJBz\XO|ZXS= NHPsc4wzOzV2ME[0OS=>
Sf9 NGHtOJdMcW6jc3WgRZN{[Xl? MVqxJIg> NE[1PGhKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM[WyyaHGg[ZhxemW|c3Xk M2fuflI{PTRyNkS1
SKOV3 NV\SXWdnU2mwYYPlJGF{e2G7 M2HxflEh|ryP NFTQNnYyKGh? MXjEUXNQ MWPJcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9v NXPPeZhFOjN|NkCzOFg>
MCF7 NGXvUJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrQcoxuOSEQvF2= MYK5OkBp NH3ydG9FVVOR Mlj1S2k2OD1yLkC3NFIh|ryP M4TuXFI{OzZyM{S4
SKOV3 NHvwfmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPxdJhlOSEQvF2= NGDD[WM6PiCq MlLOSG1UVw>? MV7HTVUxRTBwMUS3OkDPxE1? M1TGbFI{OzZyM{S4
PC3 NEDYc|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzVUYhMPzJiaB?= MoLvSG1UVw>? NH7MXJFKSzVyPUCuNlgh|ryP NELJVJMzOTl6MUexOC=>
MCF7.1 MoXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPQO|IhcA>? NYXtVFVCTE2VTx?= M1voXGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochUEWUMjDn[Y5mKHerdHigTWM2OCCxZjCwMlI5KM7:TR?= NEm0[HEzOTl6MUexOC=>
MCF7-neo/Her2 M1fYSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Lqb|czKGh? NXvkb5AxTE2VTx?= NGrqUYlKSzVyPUCuNlkh|ryP NG\PZ24zOzZ4MkmwNy=>
MCF7-neo/Her2 NWG3b3g4U2mwYYPlJGF{e2G7 MkLyTY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKEGNVDDwbI9{eGixconsZZRqd25iYYSgV|Q4OyC5aYToJGlEPTBib3[gNE4xODdizszN MX2yN|Y3OjlyMx?=
PC3 NXLwXJNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXu3NkBp MkW5SG1UVw>? NUPQXHZPTUN3ME2wMlM1KM7:TR?= NYjCSVRTOjF7OEW2N|k>
MCF7.1 NFrHeIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUO3NkBp M3;ZVWROW09? MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCHQ{WwJI9nKDBwM{mg{txO Mlr2NlE6QDV4M{m=
PC3 NFnTVnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPpPWVpPzJiaB?= NYm2cXA5TE2VTx?= MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFCFMzDj[YxteyCmZX\pZ4lmdnRiaX6gVHRGViC5aYToJGlEPTBib3[gNE4{QSEQvF2= NYr6WWRSOjByNUC2Olk>
MCF7.1 M2\FUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3raOlczKGh? NEDVbVZFVVOR M2r0UWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochWEl|S3HsdIhiKG23dHHueEB4cXSqIFnDOVAhd2ZiMD6zOEDPxE1? NV;zSmFWOjByNUC2Olk>
MCF7.1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrmUYpQPzJiaB?= Ml;zSWM2OD1yLkeyJO69VQ>? M3rjWFIxOzR4NkW2
NCI-H1975 NYe3TWdXS3m2b4TvfIlkKEG|c3H5 NXfNdXZpPzJiaB?= NYrlU4ZbUUN3ME2wMlI4KM7:TR?= MnP0NlMxPTl3NEW=
H460 M3LP[mN6fG:2b4jpZ{BCe3OjeR?= MYq3NkBp NVf6O|ZKUUN3ME2wMlg4KM7:TR?= MoW2NlMxPTl3NEW=
HT-29 NU[2VnhzS3m2b4TvfIlkKEG|c3H5 NEXMe2k4OiCq MYDJR|UxRTBwNk[g{txO Mme1NlMxPTl3NEW=
HepG2 M3;JR2N6fG:2b4jpZ{BCe3OjeR?= Mn22O|IhcA>? NIjGN3hKSzVyPUGg{txO NYjmUGtIOjNyNUm1OFU>
SGC7901 MkXMR5l1d3SxeHnjJGF{e2G7 M4P3N|czKGh? MnPhTWM2OD1zLkig{txO Mo\ENlMxPTl3NEW=
NCI-H226 MkC1R5l1d3SxeHnjJGF{e2G7 NVHZeFZzPzJiaB?= NGX1TGlKSzVyPUKuPUDPxE1? M2TXdFI{ODV7NUS1
A549 NHfpTopEgXSxdH;4bYMhSXO|YYm= M3n5OVczKGh? M{XFU2lEPTB;Nj65JO69VQ>? NIfKbIUzOzB3OUW0OS=>
U87MG MlLZR5l1d3SxeHnjJGF{e2G7 NIfQd4s4OiCq NGDvSoRKSzVyPUeuO|ch|ryP MVmyN|A2QTV2NR?=
HBC4 M1XOWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nMT4xw\0eLNUC9MVYvODNiTR?= NUfrWo92OjJ|M{[yOFY>
BSY1 MonaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETsO29td2eJSUWwQU03NjlyIF2= NYqwRVJ1OjJ|M{[yOFY>
HBC5 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfyXGFMdG:pR1m1NF0uPi54MDDN MV:yNlM{PjJ2Nh?=
MCF7 MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDn[ZVRdG:pR1m1NF0uPy5|MzDN NVLDRZNlOjJ|M{[yOFY>
MDA-MB-231 NWXvUXRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfiUpJtd2eJSUWwQU02NjR4IF2= MYOyNlM{PjJ2Nh?=
U251 NHe3PIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTucI9oT0l3ME2tOU42OCCP NYPNblRqOjJ|M{[yOFY>
SF268 MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[5NZJtd2eJSUWwQU02NjN7IF2= M{jCTFIzOzN4MkS2
SF295 NYniPI45T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK3cI9oT0l3ME2tOk4{PyCP M{j2XVIzOzN4MkS2
SF539 M2fyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;CcI9oT0l3ME2tOk42OCCP NYD6UGhoOjJ|M{[yOFY>
SNB75 NUniXWtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3X1PYxw\0eLNUC9MVcvOTBiTR?= MVGyNlM{PjJ2Nh?=
SNB78 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HTXIxw\0eLNUC9MVYvPTJiTR?= Mn7WNlI{OzZ{NE[=
HCC2998 M4jYc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zOR4xw\0eLNUC9MVYvOjliTR?= NF;UfoIzOjN|NkK0Oi=>
KM12 NYrTZ2dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHFVWhwdG:pR1m1NF0uPS55NjDN NIrXXXIzOjN|NkK0Oi=>
HT-29 NHu5dYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfhcI9oT0l3ME2tOk4{OCCP NX\3fW46OjJ|M{[yOFY>
HCT15 M1jycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnsc4dIUTVyPT22MlEzKE1? MYqyNlM{PjJ2Nh?=
HCT116 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrkcm5td2eJSUWwQU02Njh5IF2= NWr4XG9IOjJ|M{[yOFY>
NCI-H23 MmfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHmTmRVdG:pR1m1NF0uPS55MzDN MmmyNlI{OzZ{NE[=
NCI-H226 MlW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XRO4xw\0eLNUC9MVYvOjFiTR?= NWLEdYw{OjJ|M{[yOFY>
NCI-H522 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[wcI9oT0l3ME2tOk42QCCP NX\ZNYVWOjJ|M{[yOFY>
NCI-H483 MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLsc4dIUTVyPT22MlU3KE1? M2HGWFIzOzN4MkS2
A549 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrPdHdsdG:pR1m1NF0uPi5zNTDN NFXaeZozOjN|NkK0Oi=>
DMS273 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7sc4dIUTVyPT22MlQ{KE1? NYrpRnh1OjJ|M{[yOFY>
DMS114 NGnhflJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrsc4dIUTVyPT21MlkzKE1? NFTL[pczOjN|NkK0Oi=>
LOXIMVI M3XDW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDScI9oT0l3ME2tOk4zQSCP MVSyNlM{PjJ2Nh?=
OVCAR3 M2i0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrpcI9oT0l3ME2tOk44OSCP M{fk[lIzOzN4MkS2
OVCAR4 NHWzS3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjEcI9oT0l3ME2tOU44PiCP M{jreFIzOzN4MkS2
OVCAR5 M{\meWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTkcI9oT0l3ME2tOk4zPiCP MYCyNlM{PjJ2Nh?=
OVCAR8 MkTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLpbmN4dG:pR1m1NF0uPS55MzDN NGP5UWYzOjN|NkK0Oi=>
SKOV3 M1[zT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jDXoxw\0eLNUC9MVYvPTJiTR?= NWq2S|Q{OjJ|M{[yOFY>
RXF631L MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXsc4dIUTVyPT22Mlg5KE1? M3Tv[VIzOzN4MkS2
ACHN MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnsc4dIUTVyPT22MlA4KE1? MXGyNlM{PjJ2Nh?=
St-4 NHnDXIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHsc4dIUTVyPT21MlU3KE1? MkW0NlI{OzZ{NE[=
MKN1 NETuOpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXkcI9oT0l3ME2tO{4xQCCP NIP1dWIzOjN|NkK0Oi=>
MKN7 M1;QZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjsc4dIUTVyPT22MlUxKE1? MoWyNlI{OzZ{NE[=
MKN28 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLsc4dIUTVyPT21MlUzKE1? MljhNlI{OzZ{NE[=
MKN45 M3PieWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\VVpZtd2eJSUWwQU03NjV3IF2= M3XXbFIzOzN4MkS2
MKN74 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfzcI9oT0l3ME2tOk4xOiCP NHP4fmszOjN|NkK0Oi=>
DU145 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PSd4xw\0eLNUC9MVUvQDViTR?= MXGyNlM{PjJ2Nh?=
PC3 MmDTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTXV4VIdG:pR1m1NF0uPi54NjDN MWKyNlM{PjJ2Nh?=
ES5 M3\PfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33IW2lEPTB;NUCuNlEhdk1? M13yb3NCVkeHUh?=
HH NFHzS2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvHTWM2OD1zMUGuNFghdk1? NXL3XnRRW0GQR1XS
MHH-PREB-1 M3vHUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\VS2lEPTB;MUG0MlMhdk1? MVrTRW5ITVJ?
NCI-H1770 NG[xdW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPyTWM2OD1zMkOuPFYhdk1? NUOxZlVuW0GQR1XS
HuO9 Mo\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJyNj6wNkBvVQ>? NVnDdJVlW0GQR1XS
HAL-01 M1PhUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrFRoJJUUN3ME2yNFYvPzNibl2= NVPtSVRGW0GQR1XS
NOS-1 MkiwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\BTWM2OD1{MUGuPFIhdk1? NFjrfHBUSU6JRWK=
HGC-27 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTJzMj61O{BvVQ>? M1jtT3NCVkeHUh?=
NB69 Ml\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJ2NT6yO{BvVQ>? NX7uXY1MW0GQR1XS
RS4-11 NFHtN|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJ4MT63OkBvVQ>? NF7CUZVUSU6JRWK=
DOK Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLpTWM2OD1|MEGuO{BvVQ>? NEfHNJhUSU6JRWK=
LB2241-RCC NWTyd|B6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrMUo97UUN3ME2zNFMvQDRibl2= NGCyOmtUSU6JRWK=
NCI-H1623 M4LZVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\3cnJ4UUN3ME2zNFQvODhibl2= M33VcXNCVkeHUh?=
YH-13 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\GSo1DUUN3ME2zNFQvOzJibl2= NF\GS4RUSU6JRWK=
BPH-1 MoGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3f0XWlEPTB;M{G0JI5O NEPhZ45USU6JRWK=
AN3-CA MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PQXGlEPTB;M{SwMlM4KG6P MY\TRW5ITVJ?
ES7 NYjJOW9vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTN2MT65PUBvVQ>? NWLTXJY1W0GQR1XS
MDA-MB-175-VII NYnFOpBlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfNVHdKSzVyPUO1Nk46OiCwTR?= MkDzV2FPT0WU
GAMG NH:0SoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTN5MD64OUBvVQ>? MVnTRW5ITVJ?
CHL-1 MlPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvrZplKSzVyPUO3PE43PSCwTR?= NG\YelNUSU6JRWK=
NB7 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTvWnZZUUN3ME2zPFkvQDNibl2= MoTDV2FPT0WU
MFE-280 NEjLcHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2r6SGlEPTB;NEG4MlIhdk1? M4TY[nNCVkeHUh?=
HL-60 MnXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3P5d2lEPTB;NEK1Mlc2KG6P NWPOVHE1W0GQR1XS
GCIY NXKwN3Z[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTR|Mz64JI5O NIjMOHRUSU6JRWK=
MDA-MB-361 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULTeo11UUN3ME20N|kvOTNibl2= MX;TRW5ITVJ?
LXF-289 M3XBOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn22TWM2OD12NEiuNlchdk1? M2LEbHNCVkeHUh?=
NBsusSR NWq1eFRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TOVWlEPTB;NEi4Mlg2KG6P NGfmcHVUSU6JRWK=
KU-19-19 NXfue|R6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnBNHFKSzVyPUWxOk4xPyCwTR?= M4H6fXNCVkeHUh?=
A204 M3j3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\ZWWdlUUN3ME21NlIvOzNibl2= MnTIV2FPT0WU
LB1047-RCC NYWxXVJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\uXIlKSzVyPUWyNk46OyCwTR?= M3zyUXNCVkeHUh?=
COLO-684 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnWZYNIUUN3ME21NlMvOTFibl2= MlfFV2FPT0WU
PA-1 MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTV|Mj60NUBvVQ>? NHrDZYFUSU6JRWK=
MG-63 MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3r[pRKSzVyPUW0NU4yOSCwTR?= M13kUnNCVkeHUh?=
BHT-101 NYDnT|N5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XCUWlEPTB;NUS0Mlk1KG6P MlG4V2FPT0WU
NKM-1 NX35ZlNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIflbnVKSzVyPUW5N{4xQSCwTR?= M2n6bnNCVkeHUh?=
T47D Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTV7Nz61OkBvVQ>? MnjaV2FPT0WU
MOLT-4 NXSxfJJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPYeFk{UUN3ME22NlMvPjJibl2= MV\TRW5ITVJ?
IGROV-1 NILpeGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[xfGlEPTB;NkO0MlMyKG6P M1fGb3NCVkeHUh?=
ES4 NUHTdXdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTZ|OT61OEBvVQ>? MXnTRW5ITVJ?
HuO-3N1 NHrPd41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTRVYt5UUN3ME22OFIvOzhibl2= Mnq5V2FPT0WU
NEC8 NEC3UYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnT6TWM2OD14NUOuOVchdk1? NV[yXIg{W0GQR1XS
HO-1-N-1 Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nweGlEPTB;NkW5MlE4KG6P NXiyboxqW0GQR1XS
EPCL-272H NXjyeGFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HTWWlEPTB;Nki3MlIyKG6P M3XrSnNCVkeHUh?=
D-263MG M{LoOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHnTWM2OD15MUiuNUBvVQ>? NV\vXWliW0GQR1XS
MV-4-11 Mn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PJd2lEPTB;N{K0MlMyKG6P NH2zNHhUSU6JRWK=
SK-NEP-1 MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTd{NT65OEBvVQ>? Mln2V2FPT0WU
SW872 NXPmUJliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvmbYx6UUN3ME23NlcvQDlibl2= NH;BN|ZUSU6JRWK=
P30-OHK M4TacWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHGc4pKSzVyPUezNE44OSCwTR?= MXPTRW5ITVJ?
OMC-1 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3ub2ZIUUN3ME23OVEvODlibl2= M3rHb3NCVkeHUh?=
LoVo NX7sXWx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvkTWM2OD15N{euPUBvVQ>? M3nFVnNCVkeHUh?=
LNCaP-Clone-FGC NVW5XFF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTd7Nj6zOEBvVQ>? Mlu2V2FPT0WU
L-363 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULhT|JuUUN3ME23PVgvPDJibl2= MkPWV2FPT0WU
ES8 MorKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLSTWM2OD16MUCuOVIhdk1? MnPTV2FPT0WU
697 NFTV[XVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTh|MT61OUBvVQ>? NHe1eGZUSU6JRWK=
HSC-3 M4K0Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H0SWlEPTB;OEO5MlU1KG6P NW[1S|dnW0GQR1XS
H4 NF3DOXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7BTWM2OD16NUCuPFUhdk1? MoLQV2FPT0WU
QIMR-WIL NFXx[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTrRnBkUUN3ME24OlUvOiCwTR?= NFnFPWZUSU6JRWK=
OAW-42 M1Lxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTh5Mj6xPUBvVQ>? M{D5e3NCVkeHUh?=
MCF7 M1vZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjTe4JKUUN3ME24PVgvPTlibl2= MlzkV2FPT0WU
SCC-25 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTHTWM2OD17MUSuNVkhdk1? M3[wZnNCVkeHUh?=
NCI-H1563 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XYUGlEPTB;OUG1Mlk6KG6P MVPTRW5ITVJ?
OVCAR-5 NYrWe|dKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP0TWM2OD17NECuNVchdk1? MoLlV2FPT0WU
HDLM-2 NFP0NGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTl2OT6yJI5O NXL0UYZVW0GQR1XS
NB5 MoXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz0e4tKSzVyPUm1Ok43KG6P M1jt[HNCVkeHUh?=
NCI-H292 NHvYU5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIj0fWZKSzVyPUm3OE4{OiCwTR?= NFXwUWtUSU6JRWK=
A101D M32wN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXVTWM2OD17OUCuNVkhdk1? NVTTZWRCW0GQR1XS
NCI-H1648 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTl7OD61NUBvVQ>? MnLoV2FPT0WU
EKVX NH\oZ2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnjfIpmUUN3ME2xMlAyOjlizszN NY\ZVo1iW0GQR1XS
SW1710 NVPOfolLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwMESyN|Mh|ryP NVzFRmRLW0GQR1XS
WM-115 M1PmVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XIeWlEPTB;MT6wOlY2PiEQvF2= M2rlWXNCVkeHUh?=
CAL-54 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWe2XIJHUUN3ME2xMlA4ODhzIN88US=> MkLmV2FPT0WU
TGBC24TKB NHjHeVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTFwMEiwOFUh|ryP NH\DNlFUSU6JRWK=
NCI-H520 M1nnWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rJWGlEPTB;MT6wPFk3PyEQvF2= NInWXGFUSU6JRWK=
D-423MG M3;PSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1K0NmlEPTB;MT6wPVk3OiEQvF2= NYHnZlBLW0GQR1XS
BFTC-905 NW\DbmIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrYTW8yUUN3ME2xMlE{PDR7IN88US=> NYTyPVBUW0GQR1XS
HT M4TvN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\MTJVDUUN3ME2xMlE{PDd6IN88US=> NGDtTYdUSU6JRWK=
CTB-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfWXXhKSzVyPUGuNVQzQTNizszN MXvTRW5ITVJ?
Hs-578-T MlzaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTFwMUm1OlUh|ryP M1vadXNCVkeHUh?=
HuH-7 M3O5dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkX1TWM2OD1zLkKwPVQ6KM7:TR?= NYiydpZpW0GQR1XS
LB996-RCC M{fnS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTOOYRKSzVyPUGuNlIyPzdizszN NITpRlNUSU6JRWK=
KYSE-270 M2nq[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH1TWM2OD1zLkK5O|M1KM7:TR?= Mlq3V2FPT0WU
A4-Fuk M1HBZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fvfmlEPTB;MT6yPVk6OyEQvF2= Mm\GV2FPT0WU
A498 NUTmTJVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLxfoJKSzVyPUGuN|A1PzRizszN M3;6RnNCVkeHUh?=
SK-MEL-1 NGG2XHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7SXVlKSzVyPUGuN|A3PzlizszN NHLDc|FUSU6JRWK=
AU565 M1nwT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDaSY9KSzVyPUGuN|E5PjNizszN NWjISmZwW0GQR1XS
Saos-2 Mm\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3IdmNKSzVyPUGuN|MzODVizszN MVfTRW5ITVJ?
A549 NXrYZohtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnHTWM2OD1zLkO5PVch|ryP M4[ybHNCVkeHUh?=
BFTC-909 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLkUZdKUUN3ME2xMlQ{OzB3IN88US=> MnvTV2FPT0WU
MDA-MB-415 M4\1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPIbG9vUUN3ME2xMlQ5Pjl{IN88US=> NFXVXJZUSU6JRWK=
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KM-H2 Mon1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfKc5dKSzVyPUG2MlM3PDZizszN M125bXNCVkeHUh?=
LB771-HNC NHj3T4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTF4LkS0NlIh|ryP M3jacXNCVkeHUh?=
SF268 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTF4LkS1NkDPxE1? M2jJRnNCVkeHUh?=
OE19 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PSc2lEPTB;MU[uOVI1KM7:TR?= MV;TRW5ITVJ?
MLMA MkDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K5emlEPTB;MU[uOVU4OSEQvF2= NEPXd|RUSU6JRWK=
MDA-MB-231 NFTHXYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfTW45KSzVyPUG2MlcyOzZizszN MX;TRW5ITVJ?
TGW NUnyd41zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nNeGlEPTB;MU[uPFExOiEQvF2= NUnIPFUzW0GQR1XS
MDA-MB-453 Mmi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTF5LkCwNFMh|ryP MX;TRW5ITVJ?
SNU-C2B NEmydItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2KxdmlEPTB;MUeuNFI{PyEQvF2= NUHKS4s6W0GQR1XS
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IST-MEL1 MorJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWeySo44UUN3ME2xO{46OTh{IN88US=> NGDWdnpUSU6JRWK=
NCI-H1793 MmTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTF6LkG1PFEh|ryP MlSzV2FPT0WU
HCC1395 M2DLXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEP0fVRKSzVyPUG4MlU3OTFizszN NFfLW2VUSU6JRWK=
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RMG-I M2LYemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTF6LkezPFIh|ryP MV7TRW5ITVJ?
LS-513 NU\1WmhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPxTWM2OD1zOD65NlI5KM7:TR?= Ml[4V2FPT0WU
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NCI-H727 NUDwTFlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\OUZRKSzVyPUG5MlMzQTVizszN NW[0WZJNW0GQR1XS
KP-4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELpOo1KSzVyPUG5Mlg2OzFizszN MoLnV2FPT0WU
NB13 NVrWNYZGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEH6[VRKSzVyPUG5Mlg5OzlizszN NEe3fpFUSU6JRWK=
UACC-893 NEThb3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfqflVKSzVyPUG5Mlk4PTdizszN NI\0dWpUSU6JRWK=
HT-1197 NWL4ZpBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTJyLkK5OVgh|ryP NYjXUZp{W0GQR1XS
NCI-H2029 M1PHVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUmwVmNGUUN3ME2yNE4{OjZ4IN88US=> NWPUZYR2W0GQR1XS
GI-ME-N Mn\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvEV2tXUUN3ME2yNE4{Ozd|IN88US=> M1vaR3NCVkeHUh?=
OVCAR-3 M3;jSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV62Z5RSUUN3ME2yNE42QDJ{IN88US=> M3T5SXNCVkeHUh?=
HD-MY-Z MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLZTWM2OD1{MT6zOlk3KM7:TR?= NUP3PYlFW0GQR1XS
NTERA-S-cl-D1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJzLk[3NlIh|ryP NUfRXWNvW0GQR1XS
SCH NFz6eYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjubnZKSzVyPUKyMlQ6PiEQvF2= MY\TRW5ITVJ?
KARPAS-299 NV7Tb3lVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vaOWlEPTB;MkOuN|g5PyEQvF2= MW\TRW5ITVJ?
NCI-H1650 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r2fWlEPTB;MkOuPVI1OSEQvF2= MmfsV2FPT0WU
ACHN NG\mNZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrJTWM2OD1{ND60OlU3KM7:TR?= M1PYW3NCVkeHUh?=
M059J NIrnfZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH4TWM2OD1{ND61OlM1KM7:TR?= M2DpfHNCVkeHUh?=
AM-38 NYfpfotxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJ3LkS4NUDPxE1? MlnVV2FPT0WU
KG-1 MmjyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDwPVdKSzVyPUK1MlU1QTRizszN MYXTRW5ITVJ?
COLO-824 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWO0XnlzUUN3ME2yOU42PTl7IN88US=> NYfGfZlzW0GQR1XS
NCI-H1155 NHnXSHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M170fmlEPTB;MkWuOVg1PyEQvF2= MVjTRW5ITVJ?
NCI-H441 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUi0O|V7UUN3ME2yOU44PDZ3IN88US=> MonoV2FPT0WU
J-RT3-T3-5 NXX0[2xkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrGN45KSzVyPUK2MlMxOjdizszN NXXUeI9KW0GQR1XS
JEG-3 NFzMZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17BdmlEPTB;Mk[uOlgxPSEQvF2= MVXTRW5ITVJ?
RKO M4\ZTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXTfINKSzVyPUK2Mlc3OzJizszN NYPHZYV4W0GQR1XS
CAL-85-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLxTWM2OD1{Nz6yNVE5KM7:TR?= NFvLZoNUSU6JRWK=
CAL-120 M3P5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXFOJRKSzVyPUK3MlY6OTRizszN MnX1V2FPT0WU
NCI-H2452 NVPETVd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJ5Lke3NVYh|ryP NWXU[2Z6W0GQR1XS
NCI-H1395 NGi5UWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfPTIdKSzVyPUK3Mlc5OzNizszN MmDMV2FPT0WU
KYSE-450 NGXwV|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVK2SVExUUN3ME2yO{46QDZ{IN88US=> MVLTRW5ITVJ?
S-117 NWLH[lVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjHUoFKSzVyPUK5MlM5PTdizszN MWPTRW5ITVJ?
SW13 M3PhN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDpW5RKSzVyPUK5Mlg2OTlizszN MV\TRW5ITVJ?
ES3 M{jq[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPuTWM2OD1|MD6zO|M{KM7:TR?= NGL1SI9USU6JRWK=
HCT-116 NVjheVVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnKyTWM2OD1|MD61OVU1KM7:TR?= MWXTRW5ITVJ?
NCI-H1693 NWfrVY53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\nTWM2OD1|MD61PVQzKM7:TR?= MofWV2FPT0WU
VM-CUB-1 NVnsZolJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTNyLk[0NVMh|ryP MWPTRW5ITVJ?
NCI-H2170 NHvFTYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGG1dVZKSzVyPUOxMlU4QDRizszN NEGzPYZUSU6JRWK=
ALL-PO NGLs[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDWVpZoUUN3ME2zNU45PDJ6IN88US=> MlTpV2FPT0WU
NCI-H661 NHH4do1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlS5TWM2OD1|Mj6wOlI{KM7:TR?= MWTTRW5ITVJ?
NCI-H2347 NEC3O21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDzbVJtUUN3ME2zNk41QDN5IN88US=> NELiNIJUSU6JRWK=
FTC-133 MorCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTN{LkewOkDPxE1? M3O5enNCVkeHUh?=
COLO-829 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TOW2lEPTB;M{OuN|Q3PyEQvF2= M1fzenNCVkeHUh?=
GOTO NESzNFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnWUW1WUUN3ME2zN{42OjV6IN88US=> NFPGfmlUSU6JRWK=
YAPC MnTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXJVoNuUUN3ME2zN{45OTV7IN88US=> M1jyWHNCVkeHUh?=
LCLC-103H MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;KXpRkUUN3ME2zOE4yPjJ2IN88US=> MVjTRW5ITVJ?
SiHa MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXHUVU4UUN3ME2zOE4{QDF5IN88US=> M3WyPXNCVkeHUh?=
LK-2 MnrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHUeVM3UUN3ME2zOE42PzB6IN88US=> M3XtXnNCVkeHUh?=
KP-N-YS NGq0W3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3SzcGlEPTB;M{SuO|IxOiEQvF2= NHzPb5RUSU6JRWK=
NCI-SNU-1 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTN3LkG3PUDPxE1? MWnTRW5ITVJ?
KNS-81-FD MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfQTWM2OD1|NT62OlMh|ryP MVvTRW5ITVJ?
SCC-9 M3nqZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXSVnNqUUN3ME2zOk44OTR4IN88US=> Mm\4V2FPT0WU
SH-4 M1jxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXUTWM2OD1|Nj63N{DPxE1? NHyxZYNUSU6JRWK=
HCC-1954 NILXc4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;BTWM2OD1|Nz6yO|I6KM7:TR?= Mn36V2FPT0WU
BALL-1 NWjpclJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;ld4lKSzVyPUO3MlU{OTZizszN MoHZV2FPT0WU
BE-13 NX[3T2twT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjVenhKSzVyPUO3MlcxOThizszN NULVW|JNW0GQR1XS
COLO-678 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLWSo9EUUN3ME2zO{46PDN5IN88US=> NXnJbFNvW0GQR1XS
SK-MEL-3 M3K5Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nXVmlEPTB;M{iuNlM6PyEQvF2= MV;TRW5ITVJ?
OAW-28 MlL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DuZWlEPTB;M{iuOlM6KM7:TR?= NW\Nc3UzW0GQR1XS
CAMA-1 NFzad2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XObWlEPTB;M{iuPVY6OSEQvF2= NUPvVHBvW0GQR1XS
C2BBe1 NW[4cY5lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTWTWM2OD1|OT64NVgh|ryP NUH1bVNwW0GQR1XS
A3-KAW MkDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3QbFZKSzVyPUSwMlM3PjFizszN MV;TRW5ITVJ?
SK-MEL-24 MkTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTRyLkW5N|Eh|ryP MkHQV2FPT0WU
KYSE-140 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTRyLkexOlUh|ryP MlTLV2FPT0WU
MOLT-16 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi1foRRUUN3ME20NU4yPTN4IN88US=> NGnrblFUSU6JRWK=
CFPAC-1 NWDkfXIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTR{LkWyNVEh|ryP M{LWc3NCVkeHUh?=
NB14 NI\6fG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPMTWM2OD12Mj63NFI4KM7:TR?= MV3TRW5ITVJ?
COLO-792 NWrtRm5zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTR{Lki5OlEh|ryP MWXTRW5ITVJ?
RH-1 MnfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYC1ZYpQUUN3ME20N{41QDN4IN88US=> Ml\VV2FPT0WU
NCI-H522 NHftbHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzPWpVIUUN3ME20OE4{PTZ6IN88US=> M1nvVnNCVkeHUh?=
Ca-Ski NV3lNJRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTR2LkixNVQh|ryP M4DpRXNCVkeHUh?=
KGN M3[y[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTR6LkOwOlMh|ryP NHzONVdUSU6JRWK=
UACC-62 NHnrc|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn64TWM2OD12OD60NFczKM7:TR?= MULTRW5ITVJ?
NCI-H358 M1HScWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEewV2xKSzVyPUS5MlMxOThizszN MknFV2FPT0WU
LS-411N NV3Te4t3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPKTWM2OD12OT6zNVE5KM7:TR?= M37pUnNCVkeHUh?=
IST-MES1 M1XEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDCfWdHUUN3ME20PU42PjJ3IN88US=> NUjDdXA6W0GQR1XS

... Click to View More Cell Line Experimental Data

体内研究 在微粒体中,GDC-0941仅有有限的代谢,其口服生物利用度为78%[5]。GDC-0941 每天按 75 mg/kg剂量处理携带人U87MG 恶性胶质移植瘤的雌性NCr无胸腺小鼠,显著抑制生长,肿瘤生长抑制率为 83%。[1]GDC-0941 每天按 150 mg/kg剂量口服处理携带HER2扩增的抗Trastuzumab的MDA-MB-361.1移植瘤 的小鼠,抑制肿瘤生长,且显著延迟肿瘤衰退,与肿瘤中强诱导型凋亡相关。[2] GDC-0941 每天按75 mg/kg剂量处理携带自发性B细胞滤泡性淋巴瘤的PTEN+/-LKB1+/hypo小鼠,持续2周,诱导肿瘤体积下降~40%,伴随着AKT, S6K 和SGK(血清和糖皮质激素蛋白激酶)蛋白激酶的磷酸化被切除。GDC-0941抑制肿瘤细胞增殖,诱导凋亡和抑制中心母细胞数。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

闪烁接近检测:

使用p85α调节亚基,使重组人PI3Kα, PI3Kβ, 和PI3Kδ在 Sf9 杆状病毒系统中共表达,在谷胱甘肽-琼脂糖凝胶上进行亲和层析而纯化GST-融合蛋白。重组人 PI3Kγ表达作为单体 GST融合,也想上述相似方法纯化。GDC-0941 溶于DMSO,加到含200 μg硅酸钇(Ysi) 聚赖氨酸SPA 磁珠, 4 mM MgCl2, 1 mM 二硫苏糖醇 (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, 和4% (v/v) DMSO的20 mM Tris-HCl (pH 7.5)上,总体积为 50 μL。PI3Kα (5 ng), PI3Kβ(5 ng), PI3Kδ(5 ng), 或PI3Kγ(5 ng)的重组GST-融合 ,加到实验混合物中,开始激酶反应。在室温下温育1小时后, 加入150 μL PBS终止反应。混合物在2000 rpm 转速下离心2分钟,然后使用Wallac Microbeta计数器读数。在 MDL Assay Explorer系统中使用S型,剂量-反应曲线,计算进行至少2次独立重复实验,取平均值,作为IC50值。
细胞实验:

[2]

+ 展开
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, 和MKN-7
  • Concentrations: 溶于DMSO,终浓度为~10 μM
  • Incubation Time: 48,和72小时
  • Method:

    使用不同浓度 GDC-0941处理细胞48,和 72小时。通过CellTiter-Glo Luminescent细胞活性检测实验测定细胞增殖/活力。通过Western Blot分析pAKT (Ser473), cleaved caspase-3, 和cleaved PARP通过 Caspase-Glo 3/7实验和细胞死亡检测 ELISAplus 实验分别测定caspase 3/7活性, 和凋亡。


    (Only for Reference)
动物实验:

[2]

+ 展开
  • Animal Models: 移植MDA-MB-361.1细胞的NCR裸鼠, 皮下移植BT474-M1 细胞的SCID, C.B-17/IcrHsd-Prkdcscid 小鼠
  • Formulation: 溶于10% DMSO, 5% Tween-20, 85% 水
  • Dosages: ~150 mg/kg/day
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 513.64
化学式

C23H27N7O3S2

CAS号 957054-30-7
稳定性 powder
别名 RG7321

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00999128 Completed Healthy Volunteers Genentech, Inc. October 26, 2009 Phase 1
NCT02092831 Completed Healthy Volunteer Genentech, Inc. April 2014 Phase 1
NCT01740336 Active, not recruiting Breast Cancer Genentech, Inc. February 2013 Phase 2
NCT01493843 Completed Non-Squamous Non-Small Cell Lung Cancer Genentech, Inc. January 2012 Phase 2
NCT01474668 Completed Healthy Volunteer Genentech, Inc. October 2011 Phase 1
NCT01437566 Completed Breast Cancer Genentech, Inc. October 2011 Phase 2

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操作手册

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID