Pictilisib (GDC-0941)

目录号:S1065 别名: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂,在无细胞试验中IC50为 3 nM,对p110β (11倍)和p110γ (25倍)具有适度的选择性。Phase 2。

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RMB 1972.48 现货
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RMB 7926.11 现货
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客户购买Selleck的此次产品后发表的文献59篇:

客户使用该产品的9个实验数据:

  • Clonogenic assays of TNBC cell lines grown continuously in increasing concentrations of palbociclib, divided by gene expression subtypes: LAR, luminal androgen receptor; MSL, mesenchymal stem-like; MES, mesenchymal and basal-like. All cell lines are RB1 wild-type except RB1 mutant BT549.

    Clin Cancer Res, 2017, 23(18):5561-5572. Pictilisib (GDC-0941) purchased from Selleck.

    Dual PI3K/BRAF inhibition upregulates BIM and enhances apoptosis in PTEN cells. A, left, Western blot of 1205Lu cells treated with PLX4720 (3 μmol/L, 48 hours), the PI3K inhibitor GDC-0941 (3 μmol/L, 48 hours), or both drugs in combination (PtG); right, immunofluorescence staining of BIM (green) and DAPI (blue) in PTEN cells following PLX4720 treatment (3 μmol/L, 48 hours), the PI3K inhibitor LY294002 (10 μmol/L, 48 hours), or both drugs in combination (PLXtLY). B, left, immunofluorescence staining of PTEN 1205Lu following combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48hours) increases nuclear localization of FOXO3a (green). DAPI is shown in blue. Magnification 40. Right, combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48 hours) increases PTEN WM793 BIM mRNA levels to those observed with single BRAF inhibition (3 μmol/L PLX4720, 48 hours) in the PTENt WM35. C, PTEN cells were treated with PLX4720 (3 μmol/L, 48 hours), GDC-0941 (3 μmol/L, 48hours), or a combination of the 2 drugs (3Pt3G) before Annexin-V staining was analyzed by flow cytometry (*, P < 0.05 between the drug combination and each inhibitor alone). D, combined BRAF/PI3K inhibitor treatment blocks the escape of 1205Lu cells (PTEN) from therapy. Spheroids of 1205Lu cells were treated with either PLX4720 alone (3 and 10 μmol/L: data shows 3 mmol/L), LY294002 (10 μmol/L) alone or a combination of the 2 drugs for 72 hours. In other studies, spheroids were treated with drugs for 72 hours and then allowed to recover for 120 hours. Micrograph shows viability staining (green= live cells, red= dead cells). Magnification 10×.

    Cancer Res 2011 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck.

  • Combination of rapamycin and PI-103 leads to the suppression of AKT phosphorylation (phospho-specific western blot). Mel-Juso and 518A2 cells were treated with GDC-0941 from 0.05–1 μmol/L alone and in combination with rapamycin (50 nmol/L) for 24 hours. Control treatment was with DMSO.

     

     

    J Inves Der 2010 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck.

    Growth inhibition induced by the FGFR inhibitor BGJ398 and the PI3K inhibitors alone or in combination. AN3CA (A-C), JHUEM2 (D-F) and MFE296 (G-I) cells were treated with the indicated doses of BGJ398, GDC-0941 a n d BYL719 alone or in combination for 96 hours and an Sulforhodamine B (SRB) assay was subsequently performed. Data are presented as a percentage of the control, in which cells were treated with 0.1% (v/v) DMSO. Points represent the mean of three independent experiments (each performed in triplicate). Error bars represent the standard error of the mean (SEM) and lines were fitted using non-linear regression analysis. Interaction of BGJ398 and GDC-0941(redcircles) or BYL719(blacksquares) in AN3CA(C), JHUEM2(F) and MFE296(I). Median effect analysis was used to evaluate the interaction between the inhibitor combinations. Horizontal dotted lines indicate the boundaries for each interaction classification.

    Mol Cancer Ther, 2017, 16(4):637-648. Pictilisib (GDC-0941) purchased from Selleck.

  • TGF-β induces mTORC2 activation. ( A ) NMuMG cells were treated with TGF-β for the indicated times before lysis and immunoblotting. (B ) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to anti-Rictor immunoprecipitation, and the immunoprecipitates were subjected to in vitro kinase assays using kinase-inactive Akt1 as a substrate, before immunoblotting of the kinase reactions, immunoprecipitates and cell lysates. The left panels are from the same gel, without differential exposure. ( C ) NMuMG cells were treated or not with TGF-β or insulin for the indicated times, in the presence or absence of SB431542 or GDC-0941. The kinase activity of mTORC2 was then assessed as in B. The top panels are from the same gel, without differential exposure. (D) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to immunoprecipitation using Rictor antibody, and/or immunoblotted.

    J Cell Sci 2012 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck.

    After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of GDC-0941  for 3h,followed by 15-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck.

  • We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.

     

     

    Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck.

    Effects of LY294002 and GDC-0941 on the high-glucose-induced plasma membrane translocation of DGK δ1. (A, C) HEK293 cells were transfected with pAcGFP-DGKδ1 or pAcGFP-C1 vector. After being glucose-starved for 2.5 h and the subsequent pretreatment with (A) 10 μM LY294002 (Sigma-Aldrich) or (C) 1 μM GDC-0941 (Selleck Chemicals) for 30 min, the cells were incubated with or without high glucose (25 mM) for 5 min. The cells were fixed with 3.7% formaldehyde and observed using confocal laser-scanning microscopy. Scale bar = 10 μm. (B, D) After treatment with (B) LY294002 or (D) GDC-0941, the percentages of cells exhibiting the translocation of AcGFP-tagged DGK δ 1 to the plasma membrane were scored. More than 20 cells ex-pressing AcGFP-tagged DGK δ1 were counted in each experiment. The results are the means ± S.D. of three independent experiments. The statistical significance was deter-mined using Student's t -test (** P < 0.01, *** P < 0.005)

    Biochim Biophys Acta 2012 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck.

  •  

    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    Pictilisib (GDC-0941) purchased from Selleck.

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂,在无细胞试验中IC50为 3 nM,对p110β (11倍)和p110γ (25倍)具有适度的选择性。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
体外研究

GDC-0941也等效作用于PI3Kα和 PI3Kδ和PI3Kα突变型E545-K和H1047-R,也选择性作用于PI3Kβ(10倍)和 PI3Kγ(25倍), 选择性更高地作用于PI3K II, III, 和IV类成员,包括, C2β, Vps34, DNA-PK和mTOR。GDC-0941 作用于U87MG, PC3, 和 MDA-MB-361 细胞,有效抑制Akt磷酸化,IC50分别为46 nM, 37 nM,和 28 nM。GDC-0941抑制U87MG, A2780, PC3, 和MDA-MB-361细胞增殖,IC50分别为 0.95 μM, 0.14 μM, 0.28 μM, 和0.72 μM。[1]GDC-0941处理,有效抑制对Trastuzumab敏感和不敏感的HER2扩增细胞增殖,IC50为149-944 nM,与 Trastuzumab敏感性无关。GDC-0941抑制含PIK3CA突变的HER2扩增的细胞增殖,IC50<500 nM, 且有效抑制抗trastuzumab 的HER2 扩增乳腺癌细胞增殖和活力。[2]GDC-0941 显著抑制HCT116, DLD1和 HT29细胞生长,GI50分别为1081 nM, 1070 nM 和157 nM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 MmHTT4lv[XOnIFHzd4F6 MWqxJIg> NV;vRZg6TE2VTx?= NVOxcGJLUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDk[Yx1[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[SC5aYToJGlEPTBib3[gNE4xODNizszN NGPuWHkyQDd3NE[1OC=>
Sf9 MUnLbY5ie2ViQYPzZZk> NInFengyKGh? MlvZSG1UVw>? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgTFExPDdvUjDteZRidnRiZYjwdoV{e2WmIHnuJHNnQSClZXzsd{Bkd2W6cILld5NqdmdicEi1ZYxxcGFid3n0bEBKSzVyIH;mJFAvODB|IN88US=> MU[xPFc2PDZ3NB?=
Sf9 NXrhTmlpU2mwYYPlJGF{e2G7 MlHHNUBp MV3EUXNQ NGnPXW9KdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEhTTV2NT3LJI12fGGwdDDlfJBz\XO|ZXSgbY4hW2Z7IHPlcIx{KGOxZYjwdoV{e2mwZzDwPFVidHCqYTD3bZRpKEmFNUCgc4YhOC5yMEOg{txO NYjRTmd2OTh5NUS2OVQ>
Sf9 M2jUV2tqdmG|ZTDBd5NigQ>? NXr1eWRlOSCq Mnr4SG1UVw>? NH[wb49KdmirYnn0bY9vKG:oIHj1cYFvKHKnY3;tZolv[W62IGDJN2sheDFzMHLleIEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDjc4V5eHKnc4PpcocheDh3YXzwbIEhf2m2aDDJR|UxKG:oIECuNFM{KM7:TR?= NGjsU3cyQDd3NE[1OC=>
Sf9 NHXwfYxMcW6jc3WgRZN{[Xl? NFPBb3YyKGh? MkDsSG1UVw>? MoG2TY5pcWKrdHnvckBw\iCqdX3hckBz\WOxbXLpcoFvfCCSSUPLJJAyOTCjbIDoZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZS=> MXqxPFc2PDZ3NB?=
MDA-MB-361 NXfw[4kyTnWwY4Tpc44hSXO|YYm= MnjzNkBp NFnKOFVFVVOR NGrnWW5KdmirYnn0bY9vKG:oIFHreEBU\XJ2N{OgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIF3ERU1OSi1|NkGgZ4VtdHNid3n0bEBRUUt|Q1GgSVU1PS2NIH31eIF1cW:wIIfpeIghUUN3MDDv[kAxNjB{ODFOwG0> MnzENVg4PTR4NUS=
PC3 MUXGeY5kfGmxbjDBd5NigQ>? NFXIUngzKGh? MYrEUXNQ M2nQcWlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25iaX6gVHRGVi2wdXzsJIh2dWGwIGDDN{Bk\WyuczD3bZRpKEmFNUCgc4YhOC5yM{eg{txO MUixPFc2PDZ3NB?=
U87MG MoTQSpVv[3Srb36gRZN{[Xl? MlKwNkBp NISzWotFVVOR MnzmTY5pcWKrdHnvckBw\iCDa4SgV4VzPDd|IIDoc5NxcG:{eXzheIlwdiCrbjDQWGVPNW63bHygbJVu[W5iVUi3UWch[2WubIOge4l1cCCLQ{WwJI9nKDBwMES2JO69VQ>? MYmxPFc2PDZ3NB?=
MDA-MB-361 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPkUpk6PiCq NUX5VYJDTE2VTx?= MX7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlczKM7:TR?= MmP6NVg4PTR4NUS=
A2780 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV25OkBp Ml;HSG1UVw>? MlnMRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCDMke4NEBk\WyuczD3bZRpKFCLS{PDRUBidmRiUGTFUkBufXSjdHnvckB4cXSqIFnDOVAhd2ZiMD6xOEDPxE1? Ml3QNVg4PTR4NUS=
PC3 M1zBemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rRZlk3KGh? M2ey[GROW09? MWPJR|UxRTBwMkig{txO MYexPFc2PDZ3NB?=
U87MG NUnjOZRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPsNYNlQTZiaB?= MmrFSG1UVw>? MYLJR|UxRTBwOUWg{txO M3zLfFE5PzV2NkW0
Sf9 MVvLbY5ie2ViQYPzZZk> NWfwcWZ1OzBibXnu NFP0dHZFVVOR NXfBcpNHUW6qaXLpeIlwdiCxZjDoeY1idiCSSUPL[4FudWFiZYjwdoV{e2WmIHHzd4V{e2WmIHHzJIFud3WwdDDv[kBCXFBiY3;ud5Vu\WRid3n0bEBKSzVyIH;mJFAvODR{IN88US=> NYnWVYNyOjJ3NEizOFI>
RAW 264.7 NGrWUJRMcW6jc3WgRZN{[Xl? NWHmS3JMQTBibXnu Ml\lSG1UVw>? MVzJcohq[mm2aX;uJI9nKGi3bXHuJHBKO0upYX3tZUBmgHC{ZYPz[YQh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBCU1RicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlI6QCEQvF2= MYiyNlU1QDN2Mh?=
Sf9 NIrzW3dMcW6jc3WgRZN{[Xl? MlTlNUBp MYTJcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPLZoV1[SCneIDy[ZN{\WRiaX6gZoFkfWyxdnnyeZMhcW6oZXP0[YQhW0Z7IHPlcIx{KHerdHigTWM2OCCxZjCwMlAyPyEQvF2= M1LmTlI{PTRyNkS1
Sf9 MVjLbY5ie2ViQYPzZZk> NWnDUVJrOSCq MX3Jcohq[mm2aX;uJI9nKEeVVD3meZNm\CCqdX3hckBz\WOxbXLpcoFvfCCSSUPL[IVtfGFiZYjwdoV{e2Wm MXKyN|U1ODZ2NR?=
Sf9 NWq2fW9ZU2mwYYPlJGF{e2G7 MX6xJIg> M2L3cWlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2to[W2vYTDlfJBz\XO|ZXS= M33ZUFI{PTRyNkS1
Sf9 NEnwem1McW6jc3WgRZN{[Xl? MorzNUBp M{H5fmlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tidHCqYTDlfJBz\XO|ZXS= NXPqb2xQOjN3NEC2OFU>
SKOV3 NHrkZnhMcW6jc3WgRZN{[Xl? MVixJO69VQ>? NVzGZ5FpOSCq MXXEUXNQ NUPwOIpyUW6qaXLpeIlwdiCxZjDQTVNM[WyyaHGgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbh?= M3PNfVI{OzZyM{S4
MCF7 M1vzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYexJO69VQ>? NWXhTpJ[QTZiaB?= MnzmSG1UVw>? NYfQXWRLT0l3ME2wMlA4ODJizszN MnnzNlM{PjB|NEi=
SKOV3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX2xJO69VQ>? MmDkPVYhcA>? NUP6XJA3TE2VTx?= MojrS2k2OD1yLkG0O|Yh|ryP NHmzNGYzOzN4MEO0PC=>
PC3 NVSyeo9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDIW5BlPzJiaB?= M4K4[WROW09? MYjJR|UxRTBwMkig{txO Ml72NlE6QDF5MUS=
MCF7.1 M4rFN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXy3NkBp NEKyTWlFVVOR MnjkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3MlEh[2WubIOg[ZhxemW|c3nu[{BJTVJ{IHflcoUhf2m2aDDJR|UxKG:oIECuNlgh|ryP MVyyNVk5OTdzNB?=
MCF7-neo/Her2 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXPdph[PzJiaB?= MmHrSG1UVw>? M3vkdGlEPTB;MD6yPUDPxE1? MlXJNlM3PjJ7MEO=
MCF7-neo/Her2 NU\QZWJNU2mwYYPlJGF{e2G7 MkPGTY5pcWKrdHnvckBw\iCSSUPLZYxxcGFiYYPz[ZN{\WRiYYOgdoVlfWO2aX;uJI9nKEGNVDDwbI9{eGixconsZZRqd25iYYSgV|Q4OyC5aYToJGlEPTBib3[gNE4xODdizszN M1zmUlI{PjZ{OUCz
PC3 NFSzcoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XnXVczKGh? MkC1SG1UVw>? MVjFR|UxRTBwM{Sg{txO NWfPcWI1OjF7OEW2N|k>
MCF7.1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrYO|IhcA>? M4qxSWROW09? MUHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCHQ{WwJI9nKDBwM{mg{txO NVrxbW9XOjF7OEW2N|k>
PC3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfKUHF{PzJiaB?= MWrEUXNQ MonDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiZHXmbYNq\W62IHnuJHBVTU5id3n0bEBKSzVyIH;mJFAvOzlizszN Mn;XNlAxPTB4Nkm=
MCF7.1 NWewRYh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPwb4ZmPzJiaB?= MVTEUXNQ MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCLQ{WwJI9nKDBwM{Sg{txO MXqyNFA2ODZ4OR?=
MCF7.1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYe3NkBp MYrFR|UxRTBwN{Kg{txO MX[yNFM1PjZ3Nh?=
NCI-H1975 MVPDfZRwfG:6aXOgRZN{[Xl? NIPBR5I4OiCq NVvDZ3JIUUN3ME2wMlI4KM7:TR?= NFjzbXIzOzB3OUW0OS=>
H460 M37oNmN6fG:2b4jpZ{BCe3OjeR?= MkDqO|IhcA>? Mn3KTWM2OD1yLki3JO69VQ>? MV[yN|A2QTV2NR?=
HT-29 NVzkO4g2S3m2b4TvfIlkKEG|c3H5 NIHkbZM4OiCq MWnJR|UxRTBwNk[g{txO MoTjNlMxPTl3NEW=
HepG2 NITWPJZEgXSxdH;4bYMhSXO|YYm= NGn0VYw4OiCq NVjzW3VqUUN3ME2xJO69VQ>? NGTrcG8zOzB3OUW0OS=>
SGC7901 M1HtTGN6fG:2b4jpZ{BCe3OjeR?= M3[1UFczKGh? MkLSTWM2OD1zLkig{txO MmW2NlMxPTl3NEW=
NCI-H226 NX6zOYVUS3m2b4TvfIlkKEG|c3H5 MYe3NkBp MWHJR|UxRTJwOTFOwG0> NGjTVXYzOzB3OUW0OS=>
A549 MWjDfZRwfG:6aXOgRZN{[Xl? MoHaO|IhcA>? M2fn[GlEPTB;Nj65JO69VQ>? NWjoS2RyOjNyNUm1OFU>
U87MG NImwdJREgXSxdH;4bYMhSXO|YYm= NXzhR3JNPzJiaB?= NEHPNYRKSzVyPUeuO|ch|ryP NFT3ZVYzOzB3OUW0OS=>
HBC4 Mnm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTmWohtd2eJSUWwQU03NjB|IF2= NUHhc3BOOjJ|M{[yOFY>
BSY1 NXK0UnlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTuTJdtd2eJSUWwQU03NjlyIF2= MXyyNlM{PjJ2Nh?=
HBC5 NF;ONmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfZVIptd2eJSUWwQU03NjZyIF2= NHe5emgzOjN|NkK0Oi=>
MCF7 M13JUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrXXohsdG:pR1m1NF0uPy5|MzDN NIq1S5czOjN|NkK0Oi=>
MDA-MB-231 M1i4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHveG94dG:pR1m1NF0uPS52NjDN NUS5ZXk6OjJ|M{[yOFY>
U251 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnsc4dIUTVyPT21MlUxKE1? MWOyNlM{PjJ2Nh?=
SF268 M1nMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HwNIxw\0eLNUC9MVUvOzliTR?= M4DrR|IzOzN4MkS2
SF295 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LPNIxw\0eLNUC9MVYvOzdiTR?= MWSyNlM{PjJ2Nh?=
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KM12 M3ewXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPsc4dIUTVyPT21Mlc3KE1? M4LkSFIzOzN4MkS2
HT-29 MnLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7qcIVEdG:pR1m1NF0uPi5|MDDN M2DFTVIzOzN4MkS2
HCT15 Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDsc4dIUTVyPT22MlEzKE1? MVSyNlM{PjJ2Nh?=
HCT116 M1jaPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPsc4dIUTVyPT21Mlg4KE1? M1fybVIzOzN4MkS2
NCI-H23 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\wVJZtd2eJSUWwQU02Njd|IF2= Mk\2NlI{OzZ{NE[=
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NCI-H522 NInpfIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHsc4dIUTVyPT22MlU5KE1? M3HWOVIzOzN4MkS2
NCI-H483 NIjSVW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;vV4xw\0eLNUC9MVYvPTZiTR?= MW[yNlM{PjJ2Nh?=
A549 NVXxcXpPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfsc4dIUTVyPT22MlE2KE1? NIj1NXkzOjN|NkK0Oi=>
DMS273 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYr4TW94dG:pR1m1NF0uPi52MzDN NV7rfmpGOjJ|M{[yOFY>
DMS114 M4m3OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEizenNtd2eJSUWwQU02Njl{IF2= MoPCNlI{OzZ{NE[=
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OVCAR3 Ml\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nrbYxw\0eLNUC9MVYvPzFiTR?= M{\ZclIzOzN4MkS2
OVCAR4 NVHCNGpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Ht[oxw\0eLNUC9MVUvPzZiTR?= M2fGfFIzOzN4MkS2
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OVCAR8 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLKcI9oT0l3ME2tOU44OyCP NFm5NHkzOjN|NkK0Oi=>
SKOV3 M3q2bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUT0WGZxdG:pR1m1NF0uPi53MjDN NV7rUIV[OjJ|M{[yOFY>
RXF631L MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfQcI9oT0l3ME2tOk45QCCP NWH1UHk6OjJ|M{[yOFY>
ACHN MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEf0NWZtd2eJSUWwQU03NjB5IF2= MnH3NlI{OzZ{NE[=
St-4 NYDRPY9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjLcI9oT0l3ME2tOU42PiCP MnPiNlI{OzZ{NE[=
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MKN28 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLsc4dIUTVyPT21MlUzKE1? MluzNlI{OzZ{NE[=
MKN45 Mof1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXIcI9oT0l3ME2tOk42PSCP M32x[VIzOzN4MkS2
MKN74 NVrBWodUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULsc4dIUTVyPT22MlAzKE1? MlrtNlI{OzZ{NE[=
DU145 NIDifFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXFcI9oT0l3ME2tOU45PSCP M3LoflIzOzN4MkS2
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HH MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFOxc4FKSzVyPUGxNU4xQCCwTR?= NWXwVmFZW0GQR1XS
MHH-PREB-1 MmfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rIRmlEPTB;MUG0MlMhdk1? NYrIfJlHW0GQR1XS
NCI-H1770 Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljjTWM2OD1zMkOuPFYhdk1? MmXaV2FPT0WU
HuO9 NXXobllrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnezTWM2OD1{ME[uNFIhdk1? MYDTRW5ITVJ?
HAL-01 NYnUUmp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3HTWVKSzVyPUKwOk44OyCwTR?= NGrXbY1USU6JRWK=
NOS-1 NUXiWlg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTBR4hWUUN3ME2yNVEvQDJibl2= MXTTRW5ITVJ?
HGC-27 NH\RWIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7MXFlKSzVyPUKxNk42PyCwTR?= NFjNUWJUSU6JRWK=
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RS4-11 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTJ4MT63OkBvVQ>? NESwdnVUSU6JRWK=
DOK MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r4fGlEPTB;M{CxMlchdk1? MoS3V2FPT0WU
LB2241-RCC M4PiRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTNyMz64OEBvVQ>? MUTTRW5ITVJ?
NCI-H1623 NGO4VJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTNyND6wPEBvVQ>? MnHGV2FPT0WU
YH-13 NEnlSmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmG0TWM2OD1|MESuN|Ihdk1? MXrTRW5ITVJ?
BPH-1 MmfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3hOGpKSzVyPUOxOEBvVQ>? NULMPGZOW0GQR1XS
AN3-CA NFvXe|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jaSGlEPTB;M{SwMlM4KG6P NH[wN2ZUSU6JRWK=
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MDA-MB-175-VII NWPpOVZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF23SWpKSzVyPUO1Nk46OiCwTR?= MWnTRW5ITVJ?
GAMG NWT0foNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTN5MD64OUBvVQ>? MV3TRW5ITVJ?
CHL-1 MleyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rFXGlEPTB;M{e4MlY2KG6P NUHxU5liW0GQR1XS
NB7 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIWwT25KSzVyPUO4PU45OyCwTR?= MV\TRW5ITVJ?
MFE-280 NIXhUIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHhTWM2OD12MUiuNkBvVQ>? NHe3XFBUSU6JRWK=
HL-60 NULzc5doT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTR{NT63OUBvVQ>? MXPTRW5ITVJ?
GCIY M2rTXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTR|Mz64JI5O MYPTRW5ITVJ?
MDA-MB-361 M3HWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF71PJZKSzVyPUSzPU4yOyCwTR?= MVXTRW5ITVJ?
LXF-289 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILFbpVKSzVyPUS0PE4zPyCwTR?= NGDDRY1USU6JRWK=
NBsusSR NInGPJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fnPWlEPTB;NEi4Mlg2KG6P Ml\MV2FPT0WU
KU-19-19 Mn[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;obmlEPTB;NUG2MlA4KG6P NHzt[XNUSU6JRWK=
A204 NIXFe3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e4NWlEPTB;NUKyMlM{KG6P NV;JOHk{W0GQR1XS
LB1047-RCC NEC1N5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3m3[2lEPTB;NUKyMlk{KG6P MULTRW5ITVJ?
COLO-684 Mo\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljVTWM2OD13MkOuNVEhdk1? MX\TRW5ITVJ?
PA-1 MnO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfue2xuUUN3ME21N|IvPDFibl2= NIjzPHdUSU6JRWK=
MG-63 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnlTWM2OD13NEGuNVEhdk1? MVXTRW5ITVJ?
BHT-101 M4rwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\uW443UUN3ME21OFQvQTRibl2= NX21NYNEW0GQR1XS
NKM-1 M{iwW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDZeJNtUUN3ME21PVMvODlibl2= NW\mb4NZW0GQR1XS
T47D M2fyR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXOxfFcxUUN3ME21PVcvPTZibl2= M2[yTnNCVkeHUh?=
MOLT-4 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTZ{Mz62NkBvVQ>? NYTWVnFtW0GQR1XS
IGROV-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnjOIpKSzVyPU[zOE4{OSCwTR?= NUn6foFGW0GQR1XS
ES4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnrOYczUUN3ME22N|kvPTRibl2= MV\TRW5ITVJ?
HuO-3N1 M1zpWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL4PHhKSzVyPU[0Nk4{QCCwTR?= NF;WephUSU6JRWK=
NEC8 M{e2cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jKU2lEPTB;NkWzMlU4KG6P NITMNJFUSU6JRWK=
HO-1-N-1 Mn;PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4G2OWlEPTB;NkW5MlE4KG6P M{HaSnNCVkeHUh?=
EPCL-272H M17QXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTZ6Nz6yNUBvVQ>? MYXTRW5ITVJ?
D-263MG NIT4eWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHKT3NKSzVyPUexPE4yKG6P MmLFV2FPT0WU
MV-4-11 Mly4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlGyTWM2OD15MkSuN|Ehdk1? MlLsV2FPT0WU
SK-NEP-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTd{NT65OEBvVQ>? NFK5eXRUSU6JRWK=
SW872 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHZ[HVKSzVyPUeyO{45QSCwTR?= Ml;iV2FPT0WU
P30-OHK NUDrfmUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHaSHR6UUN3ME23N|AvPzFibl2= M1WzbnNCVkeHUh?=
OMC-1 MkPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DC[2lEPTB;N{WxMlA6KG6P Mn\PV2FPT0WU
LoVo MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVi3XZdNUUN3ME23O|cvQSCwTR?= NYTqXVFLW0GQR1XS
LNCaP-Clone-FGC M3HhOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnRNFlKSzVyPUe5Ok4{PCCwTR?= MYXTRW5ITVJ?
L-363 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfHUVJ3UUN3ME23PVgvPDJibl2= MX\TRW5ITVJ?
ES8 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NES4UHdKSzVyPUixNE42OiCwTR?= Mk\OV2FPT0WU
697 MojxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnsV|RKSzVyPUizNU42PSCwTR?= MWrTRW5ITVJ?
HSC-3 NEjGNlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTh|OT61OEBvVQ>? NYPwPVA4W0GQR1XS
H4 NIO5fVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T1TmlEPTB;OEWwMlg2KG6P M{m5WHNCVkeHUh?=
QIMR-WIL NYfqRm1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjGXndKSzVyPUi2OU4zKG6P MV;TRW5ITVJ?
OAW-42 NIj4NJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[5NGlEPTB;OEeyMlE6KG6P NWO4bYxVW0GQR1XS
MCF7 NXi4S4lST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\WTWM2OD16OUiuOVkhdk1? MVrTRW5ITVJ?
SCC-25 NYe4WZBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vxeWlEPTB;OUG0MlE6KG6P NVvISYtnW0GQR1XS
NCI-H1563 NYnvVIZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTlzNT65PUBvVQ>? M2fDXHNCVkeHUh?=
OVCAR-5 M1LGSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHhWo9MUUN3ME25OFAvOTdibl2= MnH1V2FPT0WU
HDLM-2 NFf1bYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1izUGlEPTB;OUS5MlIhdk1? MnHLV2FPT0WU
NB5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmL0TWM2OD17NU[uOkBvVQ>? MlvkV2FPT0WU
NCI-H292 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7rc402UUN3ME25O|QvOzJibl2= MYTTRW5ITVJ?
A101D NVi4WGg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLUTWM2OD17OUCuNVkhdk1? MXPTRW5ITVJ?
NCI-H1648 NGLreIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTl7OD61NUBvVQ>? NV2xS3o3W0GQR1XS
EKVX MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPDXFNKSzVyPUGuNFEzQSEQvF2= M{S4TXNCVkeHUh?=
SW1710 NH3MZ5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTJTWM2OD1zLkC0NlM{KM7:TR?= MUHTRW5ITVJ?
WM-115 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTFwME[2OVYh|ryP M3nDdXNCVkeHUh?=
CAL-54 NYLxXIVNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTFwMEewPFEh|ryP NF7FNXlUSU6JRWK=
TGBC24TKB M{fPbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTFwMEiwOFUh|ryP M4TZenNCVkeHUh?=
NCI-H520 NEfQT3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HTUWlEPTB;MT6wPFk3PyEQvF2= NXrsSYdvW0GQR1XS
D-423MG Moq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTFwMEm5OlIh|ryP M4XGV3NCVkeHUh?=
BFTC-905 NVq1XmtCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\wd29qUUN3ME2xMlE{PDR7IN88US=> NFLIdG1USU6JRWK=
HT NXfVR5FVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjETWM2OD1zLkGzOFc5KM7:TR?= M13UO3NCVkeHUh?=
CTB-1 NY[3XFBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PaemlEPTB;MT6xOFI6OyEQvF2= NX7kS4g3W0GQR1XS
Hs-578-T MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH64cJZKSzVyPUGuNVk2PjVizszN MYXTRW5ITVJ?
HuH-7 NY\yXGVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELqfHFKSzVyPUGuNlA6PDlizszN MYrTRW5ITVJ?
LB996-RCC NYPTfmZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwMkKxO|ch|ryP NIrub4RUSU6JRWK=
KYSE-270 MnSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTFwMkm3N|Qh|ryP NGXJd25USU6JRWK=
A4-Fuk M3TCfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f4UGlEPTB;MT6yPVk6OyEQvF2= MYjTRW5ITVJ?
A498 NVr3bXVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnW0TWM2OD1zLkOwOFc1KM7:TR?= NUPyNnpyW0GQR1XS
SK-MEL-1 M1r6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXniPGlJUUN3ME2xMlMxPjd7IN88US=> MlvGV2FPT0WU
AU565 M{\RRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTlVIZ5UUN3ME2xMlMyQDZ|IN88US=> M3P3bXNCVkeHUh?=
Saos-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrLe5ZKSzVyPUGuN|MzODVizszN MlPJV2FPT0WU
A549 MkflS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTFwM{m5O{DPxE1? MkjoV2FPT0WU
BFTC-909 M4HwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3ab|cyUUN3ME2xMlQ{OzB3IN88US=> MmL0V2FPT0WU
MDA-MB-415 MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zFTGlEPTB;MT60PFY6OiEQvF2= NHK3N2hUSU6JRWK=
639-V M2DHcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\qXIRKSzVyPUGuOVAzPDVizszN MYrTRW5ITVJ?
A704 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTI[o9{UUN3ME2xMlUxPzh3IN88US=> M1PHSHNCVkeHUh?=
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SF268 M3HOZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrWU|M2UUN3ME2xOk41PTJizszN Mnr3V2FPT0WU
OE19 M3;ETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPKTGhKSzVyPUG2MlUzPCEQvF2= M3ToNXNCVkeHUh?=
MLMA NGr1b3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\DSGlKSzVyPUG2MlU2PzFizszN NFzMSZhUSU6JRWK=
MDA-MB-231 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:3TWM2OD1zNj63NVM3KM7:TR?= NW\UUFdiW0GQR1XS
TGW M37IcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTF4LkixNFIh|ryP MmXzV2FPT0WU
MDA-MB-453 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TrVmlEPTB;MUeuNFAxOyEQvF2= NHT3e4NUSU6JRWK=
SNU-C2B MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfQTWM2OD1zNz6wNlM4KM7:TR?= MXfTRW5ITVJ?
A427 MlvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfuXIhpUUN3ME2xO{4zOzN2IN88US=> MVjTRW5ITVJ?
SK-MEL-2 NWHZPIl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETDeZlKSzVyPUG3MlMzOTNizszN Mnr3V2FPT0WU
KURAMOCHI NGHQWFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTpTWM2OD1zNz6zPFk4KM7:TR?= M{m0[3NCVkeHUh?=
IST-MEL1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTF5LkmxPFIh|ryP NHvCT3FUSU6JRWK=
NCI-H1793 MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfSVHJKSzVyPUG4MlE2QDFizszN MlXuV2FPT0WU
HCC1395 NGLsUYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLrTWM2OD1zOD61OlEyKM7:TR?= NEXPXFBUSU6JRWK=
NUGC-3 M{HZfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljRTWM2OD1zOD62OVg1KM7:TR?= NUj3NHpDW0GQR1XS
BB65-RCC MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q2b2lEPTB;MUiuOlY6KM7:TR?= M1zoTHNCVkeHUh?=
RMG-I M{\IOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVrmVFVHUUN3ME2xPE44Ozh{IN88US=> NYTmc4hSW0GQR1XS
LS-513 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7HdJpKSzVyPUG4MlkzOjhizszN NHPhdHlUSU6JRWK=
MFM-223 NF;CR2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTF7LkC3NVYh|ryP MULTRW5ITVJ?
NCI-H727 NXfmeWdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[yTWM2OD1zOT6zNlk2KM7:TR?= MV\TRW5ITVJ?
KP-4 NXPn[4t3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUH5fIZ5UUN3ME2xPU45PTNzIN88US=> NVPMOZdHW0GQR1XS
NB13 NEX5S2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnj2TWM2OD1zOT64PFM6KM7:TR?= MnrkV2FPT0WU
UACC-893 NHvYfINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7kOIRUUUN3ME2xPU46PzV5IN88US=> NVfSWlVYW0GQR1XS
HT-1197 M3\jc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTJyLkK5OVgh|ryP NVTCdG0yW0GQR1XS
NCI-H2029 NVvGd|lxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfaTWM2OD1{MD6zNlY3KM7:TR?= NUOyOWZoW0GQR1XS
GI-ME-N M37tdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJyLkOzO|Mh|ryP MoWzV2FPT0WU
OVCAR-3 MlW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3qTWM2OD1{MD61PFIzKM7:TR?= MUjTRW5ITVJ?
HD-MY-Z MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTJzLkO2PVYh|ryP NH3PRYRUSU6JRWK=
NTERA-S-cl-D1 MnfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTJzLk[3NlIh|ryP MWHTRW5ITVJ?
SCH NG\2eoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjMVXNIUUN3ME2yNk41QTZizszN NYjleVJ6W0GQR1XS
KARPAS-299 MmLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1niZWlEPTB;MkOuN|g5PyEQvF2= M3r4bHNCVkeHUh?=
NCI-H1650 Ml\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TtNWlEPTB;MkOuPVI1OSEQvF2= NGnn[pZUSU6JRWK=
ACHN M1z1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml2zTWM2OD1{ND60OlU3KM7:TR?= NILXZYNUSU6JRWK=
M059J M3HXR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfWTWM2OD1{ND61OlM1KM7:TR?= MW\TRW5ITVJ?
AM-38 NXPnPYNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PVdmlEPTB;MkWuOFgyKM7:TR?= NGDWXZFUSU6JRWK=
KG-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW2PYVKSzVyPUK1MlU1QTRizszN M2nzNnNCVkeHUh?=
COLO-824 NIrVO5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HUfGlEPTB;MkWuOVU6QSEQvF2= MlzYV2FPT0WU
NCI-H1155 NIHIXmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTyN5lKSzVyPUK1MlU5PDdizszN NX3Gc|dQW0GQR1XS
NCI-H441 MnHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJ3Lke0OlUh|ryP NULiboZHW0GQR1XS
J-RT3-T3-5 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3G3[GlEPTB;Mk[uN|AzPyEQvF2= NFPqTItUSU6JRWK=
JEG-3 MkmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJ4Lk[4NFUh|ryP MmPEV2FPT0WU
RKO MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\2TWM2OD1{Nj63OlMzKM7:TR?= NInLZlhUSU6JRWK=
CAL-85-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjOWWRKSzVyPUK3MlIyOThizszN MUXTRW5ITVJ?
CAL-120 MomyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHCT3Q4UUN3ME2yO{43QTF2IN88US=> MVfTRW5ITVJ?
NCI-H2452 NXL6UXFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7tTWM2OD1{Nz63O|E3KM7:TR?= MljPV2FPT0WU
NCI-H1395 Mn;ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTJc2dKSzVyPUK3Mlc5OzNizszN NVvRR5ZIW0GQR1XS
KYSE-450 MmjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\CfoNKUUN3ME2yO{46QDZ{IN88US=> NEjRd2ZUSU6JRWK=
S-117 MlHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknVTWM2OD1{OT6zPFU4KM7:TR?= NFfFOJpUSU6JRWK=
SW13 M{nsZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnaVHFKSzVyPUK5Mlg2OTlizszN MkHjV2FPT0WU
ES3 NVPTeHRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TtVmlEPTB;M{CuN|c{OyEQvF2= Ml7oV2FPT0WU
HCT-116 M3zkT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\vZ2lEPTB;M{CuOVU2PCEQvF2= NFKwblJUSU6JRWK=
NCI-H1693 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLsXFJKSzVyPUOwMlU6PDJizszN NFjFOIJUSU6JRWK=
VM-CUB-1 NFztZnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTNyLk[0NVMh|ryP MmCxV2FPT0WU
NCI-H2170 MorLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;pTGxZUUN3ME2zNU42Pzh2IN88US=> M2rCS3NCVkeHUh?=
ALL-PO M3HiUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;OXnRKSzVyPUOxMlg1OjhizszN MV3TRW5ITVJ?
NCI-H661 Mk\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXlTWM2OD1|Mj6wOlI{KM7:TR?= NHu0SIpUSU6JRWK=
NCI-H2347 M4XqRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;hSHBSUUN3ME2zNk41QDN5IN88US=> NYrVOnpkW0GQR1XS
FTC-133 NHvWSGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmT0TWM2OD1|Mj63NFYh|ryP M372PHNCVkeHUh?=
COLO-829 Ml\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjOTWM2OD1|Mz6zOFY4KM7:TR?= NU[wWFN7W0GQR1XS
GOTO MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jnW2lEPTB;M{OuOVI2QCEQvF2= M{XVZXNCVkeHUh?=
YAPC NWGwVmVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTN|LkixOVkh|ryP M3Lte3NCVkeHUh?=
LCLC-103H MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjOTWM2OD1|ND6xOlI1KM7:TR?= NV;5W3lxW0GQR1XS
SiHa NIDOUmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7jOogzUUN3ME2zOE4{QDF5IN88US=> NXHvZVBGW0GQR1XS
LK-2 M2PCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITTfoRKSzVyPUO0MlU4ODhizszN M{fybXNCVkeHUh?=
KP-N-YS MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\TZWlEPTB;M{SuO|IxOiEQvF2= NYXyc3dzW0GQR1XS
NCI-SNU-1 NXjJbG1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILxd|dKSzVyPUO1MlE4QSEQvF2= M3GzbXNCVkeHUh?=
KNS-81-FD M3q4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVu0UZdSUUN3ME2zOU43PjNizszN MmO4V2FPT0WU
SCC-9 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jSTWlEPTB;M{[uO|E1PiEQvF2= MnPkV2FPT0WU
SH-4 MoO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPhTWM2OD1|Nj63N{DPxE1? NITzXGpUSU6JRWK=
HCC-1954 M{HVN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLETJdKSzVyPUO3MlI4OjlizszN MUTTRW5ITVJ?
BALL-1 MmfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK5ZYVIUUN3ME2zO{42OzF4IN88US=> MlvPV2FPT0WU
BE-13 MnH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTN5LkewNVgh|ryP Mo\IV2FPT0WU
COLO-678 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vI[GlEPTB;M{euPVQ{PyEQvF2= M{jCfXNCVkeHUh?=
SK-MEL-3 MmqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGm1[pZKSzVyPUO4MlI{QTdizszN MVvTRW5ITVJ?
OAW-28 M1HEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Ppb2lEPTB;M{iuOlM6KM7:TR?= MYTTRW5ITVJ?
CAMA-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTuTWM2OD1|OD65OlkyKM7:TR?= M2TNNHNCVkeHUh?=
C2BBe1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTN7LkixPEDPxE1? MlvMV2FPT0WU
A3-KAW M{THZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\5cmlEPTB;NECuN|Y3OSEQvF2= NHnYPHZUSU6JRWK=
SK-MEL-24 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn4TWM2OD12MD61PVMyKM7:TR?= NX;MW|F6W0GQR1XS
KYSE-140 NUDVT|N1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXX0T40xUUN3ME20NE44OTZ3IN88US=> MV\TRW5ITVJ?
MOLT-16 NVzwfXUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTIdHlPUUN3ME20NU4yPTN4IN88US=> NU\WU3B3W0GQR1XS
CFPAC-1 NEKwZ2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvvVVRKSzVyPUSyMlUzOTFizszN MYXTRW5ITVJ?
NB14 NXn4c5NLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzOcXdKSzVyPUSyMlcxOjdizszN M2f2dXNCVkeHUh?=
COLO-792 Mn7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPqTWM2OD12Mj64PVYyKM7:TR?= MlrqV2FPT0WU
RH-1 NV7Bb5p2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKyNmhvUUN3ME20N{41QDN4IN88US=> NYTCZ5BHW0GQR1XS
NCI-H522 MmLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TTNGlEPTB;NESuN|U3QCEQvF2= MWrTRW5ITVJ?
Ca-Ski MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7uTWM2OD12ND64NVE1KM7:TR?= NYTySXhLW0GQR1XS
KGN MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz5TWM2OD12OD6zNFY{KM7:TR?= MWPTRW5ITVJ?
UACC-62 NHLMUI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrofVNKSzVyPUS4MlQxPzJizszN NXG5T2l7W0GQR1XS
NCI-H358 MoXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTR7LkOwNVgh|ryP MXvTRW5ITVJ?
LS-411N MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvZXJRDUUN3ME20PU4{OTF6IN88US=> Mn3YV2FPT0WU
IST-MES1 M1;D[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LETGlEPTB;NEmuOVYzPSEQvF2= MVPTRW5ITVJ?

... Click to View More Cell Line Experimental Data

体内研究 在微粒体中,GDC-0941仅有有限的代谢,其口服生物利用度为78%[5]。GDC-0941 每天按 75 mg/kg剂量处理携带人U87MG 恶性胶质移植瘤的雌性NCr无胸腺小鼠,显著抑制生长,肿瘤生长抑制率为 83%。[1]GDC-0941 每天按 150 mg/kg剂量口服处理携带HER2扩增的抗Trastuzumab的MDA-MB-361.1移植瘤 的小鼠,抑制肿瘤生长,且显著延迟肿瘤衰退,与肿瘤中强诱导型凋亡相关。[2] GDC-0941 每天按75 mg/kg剂量处理携带自发性B细胞滤泡性淋巴瘤的PTEN+/-LKB1+/hypo小鼠,持续2周,诱导肿瘤体积下降~40%,伴随着AKT, S6K 和SGK(血清和糖皮质激素蛋白激酶)蛋白激酶的磷酸化被切除。GDC-0941抑制肿瘤细胞增殖,诱导凋亡和抑制中心母细胞数。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

闪烁接近检测:

使用p85α调节亚基,使重组人PI3Kα, PI3Kβ, 和PI3Kδ在 Sf9 杆状病毒系统中共表达,在谷胱甘肽-琼脂糖凝胶上进行亲和层析而纯化GST-融合蛋白。重组人 PI3Kγ表达作为单体 GST融合,也想上述相似方法纯化。GDC-0941 溶于DMSO,加到含200 μg硅酸钇(Ysi) 聚赖氨酸SPA 磁珠, 4 mM MgCl2, 1 mM 二硫苏糖醇 (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, 和4% (v/v) DMSO的20 mM Tris-HCl (pH 7.5)上,总体积为 50 μL。PI3Kα (5 ng), PI3Kβ(5 ng), PI3Kδ(5 ng), 或PI3Kγ(5 ng)的重组GST-融合 ,加到实验混合物中,开始激酶反应。在室温下温育1小时后, 加入150 μL PBS终止反应。混合物在2000 rpm 转速下离心2分钟,然后使用Wallac Microbeta计数器读数。在 MDL Assay Explorer系统中使用S型,剂量-反应曲线,计算进行至少2次独立重复实验,取平均值,作为IC50值。
细胞实验:

[2]

+ 展开
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, 和MKN-7
  • Concentrations: 溶于DMSO,终浓度为~10 μM
  • Incubation Time: 48,和72小时
  • Method:

    使用不同浓度 GDC-0941处理细胞48,和 72小时。通过CellTiter-Glo Luminescent细胞活性检测实验测定细胞增殖/活力。通过Western Blot分析pAKT (Ser473), cleaved caspase-3, 和cleaved PARP通过 Caspase-Glo 3/7实验和细胞死亡检测 ELISAplus 实验分别测定caspase 3/7活性, 和凋亡。


    (Only for Reference)
动物实验:

[2]

+ 展开
  • Animal Models: 移植MDA-MB-361.1细胞的NCR裸鼠, 皮下移植BT474-M1 细胞的SCID, C.B-17/IcrHsd-Prkdcscid 小鼠
  • Formulation: 溶于10% DMSO, 5% Tween-20, 85% 水
  • Dosages: ~150 mg/kg/day
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 513.64
化学式

C23H27N7O3S2

CAS号 957054-30-7
稳定性 powder
in solvent
别名 RG7321

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00999128 Completed Healthy Volunteers Genentech, Inc. October 26, 2009 Phase 1
NCT02092831 Completed Healthy Volunteer Genentech, Inc. April 2014 Phase 1
NCT01740336 Active, not recruiting Breast Cancer Genentech, Inc. February 2013 Phase 2
NCT01493843 Completed Non-Squamous Non-Small Cell Lung Cancer Genentech, Inc. January 2012 Phase 2
NCT01474668 Completed Healthy Volunteer Genentech, Inc. October 2011 Phase 1
NCT01437566 Completed Breast Cancer Genentech, Inc. October 2011 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID