Pictilisib (GDC-0941)

目录号:S1065 别名: RG7321

Pictilisib (GDC-0941) Chemical Structure

Molecular Weight(MW): 513.64

Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂,在无细胞试验中IC50为 3 nM,对p110β (11倍)和p110γ (25倍)具有适度的选择性。Phase 2。

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RMB 1972.48 现货
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客户购买Selleck的此次产品后发表的文献59篇:

客户使用该产品的9个实验数据:

  • Clonogenic assays of TNBC cell lines grown continuously in increasing concentrations of palbociclib, divided by gene expression subtypes: LAR, luminal androgen receptor; MSL, mesenchymal stem-like; MES, mesenchymal and basal-like. All cell lines are RB1 wild-type except RB1 mutant BT549.

    Clin Cancer Res, 2017, 23(18):5561-5572. Pictilisib (GDC-0941) purchased from Selleck.

    Dual PI3K/BRAF inhibition upregulates BIM and enhances apoptosis in PTEN cells. A, left, Western blot of 1205Lu cells treated with PLX4720 (3 μmol/L, 48 hours), the PI3K inhibitor GDC-0941 (3 μmol/L, 48 hours), or both drugs in combination (PtG); right, immunofluorescence staining of BIM (green) and DAPI (blue) in PTEN cells following PLX4720 treatment (3 μmol/L, 48 hours), the PI3K inhibitor LY294002 (10 μmol/L, 48 hours), or both drugs in combination (PLXtLY). B, left, immunofluorescence staining of PTEN 1205Lu following combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48hours) increases nuclear localization of FOXO3a (green). DAPI is shown in blue. Magnification 40. Right, combined inhibition (3 μmol/L PLX4720 t 10 μmol/L LY294002, 48 hours) increases PTEN WM793 BIM mRNA levels to those observed with single BRAF inhibition (3 μmol/L PLX4720, 48 hours) in the PTENt WM35. C, PTEN cells were treated with PLX4720 (3 μmol/L, 48 hours), GDC-0941 (3 μmol/L, 48hours), or a combination of the 2 drugs (3Pt3G) before Annexin-V staining was analyzed by flow cytometry (*, P < 0.05 between the drug combination and each inhibitor alone). D, combined BRAF/PI3K inhibitor treatment blocks the escape of 1205Lu cells (PTEN) from therapy. Spheroids of 1205Lu cells were treated with either PLX4720 alone (3 and 10 μmol/L: data shows 3 mmol/L), LY294002 (10 μmol/L) alone or a combination of the 2 drugs for 72 hours. In other studies, spheroids were treated with drugs for 72 hours and then allowed to recover for 120 hours. Micrograph shows viability staining (green= live cells, red= dead cells). Magnification 10×.

    Cancer Res 2011 71, 2750-2760. Pictilisib (GDC-0941) purchased from Selleck.

  • Combination of rapamycin and PI-103 leads to the suppression of AKT phosphorylation (phospho-specific western blot). Mel-Juso and 518A2 cells were treated with GDC-0941 from 0.05–1 μmol/L alone and in combination with rapamycin (50 nmol/L) for 24 hours. Control treatment was with DMSO.

     

     

    J Inves Der 2010 131, 495-503. Pictilisib (GDC-0941) purchased from Selleck.

    Growth inhibition induced by the FGFR inhibitor BGJ398 and the PI3K inhibitors alone or in combination. AN3CA (A-C), JHUEM2 (D-F) and MFE296 (G-I) cells were treated with the indicated doses of BGJ398, GDC-0941 a n d BYL719 alone or in combination for 96 hours and an Sulforhodamine B (SRB) assay was subsequently performed. Data are presented as a percentage of the control, in which cells were treated with 0.1% (v/v) DMSO. Points represent the mean of three independent experiments (each performed in triplicate). Error bars represent the standard error of the mean (SEM) and lines were fitted using non-linear regression analysis. Interaction of BGJ398 and GDC-0941(redcircles) or BYL719(blacksquares) in AN3CA(C), JHUEM2(F) and MFE296(I). Median effect analysis was used to evaluate the interaction between the inhibitor combinations. Horizontal dotted lines indicate the boundaries for each interaction classification.

    Mol Cancer Ther, 2017, 16(4):637-648. Pictilisib (GDC-0941) purchased from Selleck.

  • TGF-β induces mTORC2 activation. ( A ) NMuMG cells were treated with TGF-β for the indicated times before lysis and immunoblotting. (B ) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to anti-Rictor immunoprecipitation, and the immunoprecipitates were subjected to in vitro kinase assays using kinase-inactive Akt1 as a substrate, before immunoblotting of the kinase reactions, immunoprecipitates and cell lysates. The left panels are from the same gel, without differential exposure. ( C ) NMuMG cells were treated or not with TGF-β or insulin for the indicated times, in the presence or absence of SB431542 or GDC-0941. The kinase activity of mTORC2 was then assessed as in B. The top panels are from the same gel, without differential exposure. (D) NMuMG cells were treated or not with TGF-β for the indicated times, in the presence or absence of SB431542 or LY294002. Cell lysates were subjected to immunoprecipitation using Rictor antibody, and/or immunoblotted.

    J Cell Sci 2012 125(Pt 5), 1259-73. Pictilisib (GDC-0941) purchased from Selleck.

    Effects of LY294002 and GDC-0941 on the high-glucose-induced plasma membrane translocation of DGK δ1. (A, C) HEK293 cells were transfected with pAcGFP-DGKδ1 or pAcGFP-C1 vector. After being glucose-starved for 2.5 h and the subsequent pretreatment with (A) 10 μM LY294002 (Sigma-Aldrich) or (C) 1 μM GDC-0941 (Selleck Chemicals) for 30 min, the cells were incubated with or without high glucose (25 mM) for 5 min. The cells were fixed with 3.7% formaldehyde and observed using confocal laser-scanning microscopy. Scale bar = 10 μm. (B, D) After treatment with (B) LY294002 or (D) GDC-0941, the percentages of cells exhibiting the translocation of AcGFP-tagged DGK δ 1 to the plasma membrane were scored. More than 20 cells ex-pressing AcGFP-tagged DGK δ1 were counted in each experiment. The results are the means ± S.D. of three independent experiments. The statistical significance was deter-mined using Student's t -test (** P < 0.01, *** P < 0.005)

    Biochim Biophys Acta 2012 1823, 2210-6. Pictilisib (GDC-0941) purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of GDC-0941  for 3h,followed by 15-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Pictilisib (GDC-0941) purchased from Selleck.

    We treated all of drugs in T47D which has a PI3KCA H1044R mutation with the concentration shown below for 1 hour and performed western blot analysis using antibodies to phospho-AKT(SERINE 472), and total AKT.

     

     

    Saraswati Sukumar of Johns Hopkins University School of Medicine. Pictilisib (GDC-0941) purchased from Selleck.

  •  

    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    Pictilisib (GDC-0941) purchased from Selleck.

产品安全说明书

PI3K抑制剂选择性比较

生物活性

产品描述 Pictilisib (GDC-0941) 是一种有效的PI3Kα/δ抑制剂,在无细胞试验中IC50为 3 nM,对p110β (11倍)和p110γ (25倍)具有适度的选择性。Phase 2。
靶点
p110α [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
p110β [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR [1]
(Cell-free assay)
3 nM 3 nM 33 nM 75 nM 0.58 μM(Ki app)
体外研究

GDC-0941也等效作用于PI3Kα和 PI3Kδ和PI3Kα突变型E545-K和H1047-R,也选择性作用于PI3Kβ(10倍)和 PI3Kγ(25倍), 选择性更高地作用于PI3K II, III, 和IV类成员,包括, C2β, Vps34, DNA-PK和mTOR。GDC-0941 作用于U87MG, PC3, 和 MDA-MB-361 细胞,有效抑制Akt磷酸化,IC50分别为46 nM, 37 nM,和 28 nM。GDC-0941抑制U87MG, A2780, PC3, 和MDA-MB-361细胞增殖,IC50分别为 0.95 μM, 0.14 μM, 0.28 μM, 和0.72 μM。[1]GDC-0941处理,有效抑制对Trastuzumab敏感和不敏感的HER2扩增细胞增殖,IC50为149-944 nM,与 Trastuzumab敏感性无关。GDC-0941抑制含PIK3CA突变的HER2扩增的细胞增殖,IC50<500 nM, 且有效抑制抗trastuzumab 的HER2 扩增乳腺癌细胞增殖和活力。[2]GDC-0941 显著抑制HCT116, DLD1和 HT29细胞生长,GI50分别为1081 nM, 1070 nM 和157 nM。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Sf9 NYfBZ|lXU2mwYYPlJGF{e2G7 NIXNVZIyKGh? NWXYdYVYTE2VTx?= MY\Jcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGSnbIThJIV5eHKnc4Pl[EBqdiCVZkmgZ4VtdHNiY3;lfJBz\XO|aX7nJJA5PWGucHjhJJdqfGhiSVO1NEBw\iByLkCwN{DPxE1? MU[xPFc2PDZ3NB?=
Sf9 MUTLbY5ie2ViQYPzZZk> M2XtZVEhcA>? M3fYfGROW09? M3;4OmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBJOTB2Nz3SJI12fGGwdDDlfJBz\XO|ZXSgbY4hW2Z7IHPlcIx{KGOxZYjwdoV{e2mwZzDwPFVidHCqYTD3bZRpKEmFNUCgc4YhOC5yMEOg{txO NFvLenYyQDd3NE[1OC=>
Sf9 MUnLbY5ie2ViQYPzZZk> M1\ZVFEhcA>? NHLqT4hFVVOR MWfJcohq[mm2aX;uJI9nKGi3bXHuJJJm[2:vYnnuZY51KFCLM1ugdFEyOGKndHGgSVU1PS2NIH31eIFvfCCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[SC5aYToJGlEPTBib3[gNE4xODNizszN MYKxPFc2PDZ3NB?=
Sf9 NV7SbnBFU2mwYYPlJGF{e2G7 MU[xJIg> NFnz[mNFVVOR M{LlWmlvcGmkaYTpc44hd2ZiaIXtZY4hemWlb33ibY5idnRiUFmzT{BxOTFyYnX0ZUBmgHC{ZYPz[YQhcW5iU3[5JINmdGy|IHPv[ZhxemW|c3nu[{BxQDWjbIDoZUB4cXSqIFnDOVAhd2ZiMD6wN|Mh|ryP M{nuWlE5PzV2NkW0
Sf9 NVq5eIdRU2mwYYPlJGF{e2G7 MVKxJIg> MVjEUXNQ NVfIfFdwUW6qaXLpeIlwdiCxZjDoeY1idiC{ZXPvcYJqdmGwdDDQTVNMKHBzMUDhcJBp[SCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJINw\XiycnXzd4lv\yCyOEXhcJBp[Q>? NHm1SXkyQDd3NE[1OC=>
MDA-MB-361 NEL6VGFHfW6ldHnvckBCe3OjeR?= M4LXbVIhcA>? NYfKbYNvTE2VTx?= MULJcohq[mm2aX;uJI9nKEGtdDDT[ZI1PzNicHjvd5Bpd3K7bHH0bY9vKGmwIHj1cYFvKE2GQT3NRk0{PjFiY3XscJMhf2m2aDDQTWs{S0FiRUW0OU1MKG23dHH0bY9vKHerdHigTWM2OCCxZjCwMlAzQCEQvF2= MW[xPFc2PDZ3NB?=
PC3 M2\idmZ2dmO2aX;uJGF{e2G7 M3fkc|IhcA>? NUTDeHBFTE2VTx?= NVTGWY9oUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBRXEWQLX71cIwhcHWvYX6gVGM{KGOnbHzzJJdqfGhiSVO1NEBw\iByLkCzO{DPxE1? NWiw[Y5KOTh5NUS2OVQ>
U87MG NHXEOnBHfW6ldHnvckBCe3OjeR?= NWfSV4xxOiCq Mn7JSG1UVw>? NV7HfoRSUW6qaXLpeIlwdiCxZjDBb5QhW2W{NEezJJBpd3OyaH;yfYxifGmxbjDpckBRXEWQLX71cIwhcHWvYX6gWVg4VUdiY3XscJMhf2m2aDDJR|UxKG:oIECuNFQ3KM7:TR?= NGHJdY0yQDd3NE[1OC=>
MDA-MB-361 NUHFWpp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWf3VHUxQTZiaB?= M3;YWWROW09? M{XIXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVTBMW1DNTN4MTDj[YxteyC5aYToJHBKUzOFQTDFOVQ2NUtibYX0ZZRqd25id3n0bEBKSzVyIH;mJFAvPzJizszN NHX3e3EyQDd3NE[1OC=>
A2780 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmX5PVYhcA>? NFX6TlFFVVOR MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEF{N{iwJINmdGy|IIfpeIghWEmNM1PBJIFv\CCSVFXOJI12fGG2aX;uJJdqfGhiSVO1NEBw\iByLkG0JO69VQ>? NYHaWWxNOTh5NUS2OVQ>
PC3 Mm\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDBN4k6PiCq M2S2PGROW09? M3vlWWlEPTB;MD6yPEDPxE1? MUSxPFc2PDZ3NB?=
U87MG NXO1V|Q1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnj2PVYhcA>? MmjDSG1UVw>? NETIOplKSzVyPUCuPVUh|ryP NH3IO3kyQDd3NE[1OC=>
Sf9 MnzRT4lv[XOnIFHzd4F6 Mnf5N|AhdWmw MWTEUXNQ NHTmTJJKdmirYnn0bY9vKG:oIHj1cYFvKFCLM1vnZY1u[SCneIDy[ZN{\WRiYYPz[ZN{\WRiYYOgZY1wfW62IH;mJGFVWCClb37zeY1m\CC5aYToJGlEPTBib3[gNE4xPDJizszN MlTsNlI2PDh|NEK=
RAW 264.7 Ml;0T4lv[XOnIFHzd4F6 M1[2N|kxKG2rbh?= Mn;XSG1UVw>? M4DjeWlvcGmkaYTpc44hd2ZiaIXtZY4hWEl|S3fhcY1iKGW6cILld5Nm\CCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEGNVDDwbI9{eGixconsZZRqd25id3n0bEBKSzVyIH;mJFAvOjl6IN88US=> MomzNlI2PDh|NEK=
Sf9 NEnr[ZhMcW6jc3WgRZN{[Xl? M1Xqc|EhcA>? Mn;rTY5pcWKrdHnvckBw\iCJU2St[pV{\WRiaIXtZY4hemWlb33ibY5idnRiUFmzT4JmfGFiZYjwdoV{e2WmIHnuJIJi[3Wub4\pdpV{KGmwZnXjeIVlKFOIOTDj[YxteyC5aYToJGlEPTBib3[gNE4xOTdizszN NILxZ44zOzV2ME[0OS=>
Sf9 Mm\ST4lv[XOnIFHzd4F6 MV:xJIg> NIjJfFdKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM\GWudHGg[ZhxemW|c3Xk MljBNlM2PDB4NEW=
Sf9 MUTLbY5ie2ViQYPzZZk> MmTONUBp NFTUeINKdmirYnn0bY9vKG:oIFfTWE1nfXOnZDDoeY1idiC{ZXPvcYJqdmGwdDDQTVNM\2GvbXGg[ZhxemW|c3Xk NXnhfIk6OjN3NEC2OFU>
Sf9 M3;2VmtqdmG|ZTDBd5NigQ>? Mm\yNUBp M{HtdmlvcGmkaYTpc44hd2ZiR2PUMYZ2e2WmIHj1cYFvKHKnY3;tZolv[W62IGDJN2tidHCqYTDlfJBz\XO|ZXS= MV6yN|U1ODZ2NR?=
SKOV3 NXOzO25IU2mwYYPlJGF{e2G7 NGjPZWgyKM7:TR?= MVGxJIg> M3y3fWROW09? M1XPPGlvcGmkaYTpc44hd2ZiUFmzT4FteGijIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiQXv0JHNmejR5MzDwbI9{eGixconsZZRqd25? NILyUmkzOzN4MEO0PC=>
MCF7 NHP3NWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17VWVEh|ryP NGP1R3Q6PiCq MlTwSG1UVw>? MnfCS2k2OD1yLkC3NFIh|ryP NIjRfowzOzN4MEO0PC=>
SKOV3 NGnPcW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[welEh|ryP M1LSbFk3KGh? M{\wNmROW09? NYmzTYR1T0l3ME2wMlE1PzZizszN M4TiW|I{OzZyM{S4
PC3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX[3NkBp M1ntUmROW09? NFHUVFJKSzVyPUCuNlgh|ryP NYLDNWZSOjF7OEG3NVQ>
MCF7.1 NU\tNFJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYC3NkBp M3fvbmROW09? MVLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJGhGWjJiZ3Xu[UB4cXSqIFnDOVAhd2ZiMD6yPEDPxE1? NF7p[YozOTl6MUexOC=>
MCF7-neo/Her2 MnW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XmN|czKGh? NYezN|g1TE2VTx?= NYLkT5lwUUN3ME2wMlI6KM7:TR?= M1\SR|I{PjZ{OUCz
MCF7-neo/Her2 NI\rVlVMcW6jc3WgRZN{[Xl? MWXJcohq[mm2aX;uJI9nKFCLM1vhcJBp[SCjc4Pld5Nm\CCjczDy[YR2[3Srb36gc4YhSUuWIIDoc5NxcG:{eXzheIlwdiCjdDDTOFc{KHerdHigTWM2OCCxZjCwMlAxPyEQvF2= M2jxUlI{PjZ{OUCz
PC3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXHSlFIPzJiaB?= MYrEUXNQ M4LNfGVEPTB;MD6zOEDPxE1? MYiyNVk5PTZ|OR?=
MCF7.1 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4K2dFczKGh? MUjEUXNQ MWrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkeuNUBk\WyuczDlfJBz\XO|aX7nJHBKO0ujbIDoZUBufXSjboSge4l1cCCHQ{WwJI9nKDBwM{mg{txO NIXqU3gzOTl6NU[zPS=>
PC3 MoDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XRelczKGh? NYDmZ2t3TE2VTx?= NFHTelNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDDN{Bk\WyuczDk[YZq[2mnboSgbY4hWFSHTjD3bZRpKEmFNUCgc4YhOC5|OTFOwG0> NWfTfVltOjByNUC2Olk>
MCF7.1 MoH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;3ZVczKGh? NVPaZW9HTE2VTx?= M3\tUmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTVPGO{4yKGOnbHzzJIV5eHKnc4PpcochWEl|S3HsdIhiKG23dHHueEB4cXSqIFnDOVAhd2ZiMD6zOEDPxE1? MViyNFA2ODZ4OR?=
MCF7.1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUi3NkBp NInQWmlGSzVyPUCuO|Ih|ryP M2TOR|IxOzR4NkW2
NCI-H1975 MUPDfZRwfG:6aXOgRZN{[Xl? MXe3NkBp M1HvWGlEPTB;MD6yO{DPxE1? NUH4ZnJmOjNyNUm1OFU>
H460 NGTTfXJEgXSxdH;4bYMhSXO|YYm= M1viV|czKGh? MUTJR|UxRTBwOEeg{txO Mk\2NlMxPTl3NEW=
HT-29 MXTDfZRwfG:6aXOgRZN{[Xl? NXfFZ5FzPzJiaB?= M3LVcmlEPTB;MD62OkDPxE1? M2\WUVI{ODV7NUS1
HepG2 MWPDfZRwfG:6aXOgRZN{[Xl? Mo\mO|IhcA>? M4\2RWlEPTB;MTFOwG0> M4[wPVI{ODV7NUS1
SGC7901 NILZc2NEgXSxdH;4bYMhSXO|YYm= NWDNU49ZPzJiaB?= NH[2S4FKSzVyPUGuPEDPxE1? MnfuNlMxPTl3NEW=
NCI-H226 NUnIS|N5S3m2b4TvfIlkKEG|c3H5 NVPRSIdwPzJiaB?= MWLJR|UxRTJwOTFOwG0> M2jlUVI{ODV7NUS1
A549 M1vSUWN6fG:2b4jpZ{BCe3OjeR?= NWXYeW5iPzJiaB?= NHvpSIhKSzVyPU[uPUDPxE1? Mn34NlMxPTl3NEW=
U87MG M2Lo[GN6fG:2b4jpZ{BCe3OjeR?= M4fHUVczKGh? MnPpTWM2OD15Lke3JO69VQ>? NIPQbWEzOzB3OUW0OS=>
HBC4 NGLnWHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXXOXlYdG:pR1m1NF0uPi5yMzDN NIfOcVQzOjN|NkK0Oi=>
BSY1 NIrDfJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPU[o41dG:pR1m1NF0uPi57MDDN MX[yNlM{PjJ2Nh?=
HBC5 MkHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3X1e4xw\0eLNUC9MVYvPjBiTR?= M3vOWlIzOzN4MkS2
MCF7 NGSwN4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3j4coxw\0eLNUC9MVcvOzNiTR?= M37Tc|IzOzN4MkS2
MDA-MB-231 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlKxcI9oT0l3ME2tOU41PiCP NX:1W3hmOjJ|M{[yOFY>
U251 MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DkVoxw\0eLNUC9MVUvPTBiTR?= MoXCNlI{OzZ{NE[=
SF268 NInJXXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDwcI9oT0l3ME2tOU4{QSCP MXiyNlM{PjJ2Nh?=
SF295 Mnn5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmmycI9oT0l3ME2tOk4{PyCP MljhNlI{OzZ{NE[=
SF539 NUX6WGZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHQcI9oT0l3ME2tOk42OCCP MWmyNlM{PjJ2Nh?=
SNB75 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrsc4dIUTVyPT23MlExKE1? NXy3bYVLOjJ|M{[yOFY>
SNB78 M1LHcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTDcI9oT0l3ME2tOk42OiCP M2\SPFIzOzN4MkS2
HCC2998 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HSZYxw\0eLNUC9MVYvOjliTR?= MlS1NlI{OzZ{NE[=
KM12 NFruVGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXj2W49HdG:pR1m1NF0uPS55NjDN Mni5NlI{OzZ{NE[=
HT-29 NUi3[nRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfsc4dIUTVyPT22MlMxKE1? MVyyNlM{PjJ2Nh?=
HCT15 M2L6Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHGNJJudG:pR1m1NF0uPi5zMjDN NFnWTIkzOjN|NkK0Oi=>
HCT116 M324T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXQcI9oT0l3ME2tOU45PyCP MWmyNlM{PjJ2Nh?=
NCI-H23 Mn;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLTRXptd2eJSUWwQU02Njd|IF2= MoHqNlI{OzZ{NE[=
NCI-H226 M{fZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTXfJNWdG:pR1m1NF0uPi5{MTDN MlfoNlI{OzZ{NE[=
NCI-H522 NX\teHdHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYi1R2FJdG:pR1m1NF0uPi53ODDN M4POb|IzOzN4MkS2
NCI-H483 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;6cI9oT0l3ME2tOk42PiCP MlfVNlI{OzZ{NE[=
A549 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVSzd3h5dG:pR1m1NF0uPi5zNTDN MUSyNlM{PjJ2Nh?=
DMS273 MlHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGWxTVhtd2eJSUWwQU03NjR|IF2= M3vjNFIzOzN4MkS2
DMS114 M2LWfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHsc4dIUTVyPT21MlkzKE1? MmjaNlI{OzZ{NE[=
LOXIMVI NF;XNG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPzcI9oT0l3ME2tOk4zQSCP M1TDOVIzOzN4MkS2
OVCAR3 MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfrVHFtd2eJSUWwQU03NjdzIF2= NEO0U3ozOjN|NkK0Oi=>
OVCAR4 NIHhRXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHi[GFtd2eJSUWwQU02Njd4IF2= NWjqXmZyOjJ|M{[yOFY>
OVCAR5 NXnhbGFUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPUdYhUdG:pR1m1NF0uPi5{NjDN MUiyNlM{PjJ2Nh?=
OVCAR8 NI[xfnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTNcI9oT0l3ME2tOU44OyCP MoTkNlI{OzZ{NE[=
SKOV3 M{G2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTISo1qdG:pR1m1NF0uPi53MjDN NFz5OHUzOjN|NkK0Oi=>
RXF631L MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\UU3Ztd2eJSUWwQU03Njh6IF2= M4X0e|IzOzN4MkS2
ACHN NIO3VnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTjTFJtd2eJSUWwQU03NjB5IF2= NF\TNpczOjN|NkK0Oi=>
St-4 NUjNXnh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHleVFtd2eJSUWwQU02NjV4IF2= MmLUNlI{OzZ{NE[=
MKN1 NEPUb4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrncI9oT0l3ME2tO{4xQCCP NYrRbFdEOjJ|M{[yOFY>
MKN7 M2XucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fqdoxw\0eLNUC9MVYvPTBiTR?= MX2yNlM{PjJ2Nh?=
MKN28 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPDcI9oT0l3ME2tOU42OiCP MYqyNlM{PjJ2Nh?=
MKN45 M1HhXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfU[2pWdG:pR1m1NF0uPi53NTDN NWrG[VZKOjJ|M{[yOFY>
MKN74 Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTROnFEdG:pR1m1NF0uPi5yMjDN NX3JTohFOjJ|M{[yOFY>
DU145 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzGO21td2eJSUWwQU02Njh3IF2= M3zKZlIzOzN4MkS2
PC3 NXfob5c5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlm5cI9oT0l3ME2tOk43PiCP M2PRcFIzOzN4MkS2
ES5 NHHx[XdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlO0TWM2OD13MD6yNUBvVQ>? MUXTRW5ITVJ?
HH NGLKXZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\ORpNKSzVyPUGxNU4xQCCwTR?= NXi2PG1{W0GQR1XS
MHH-PREB-1 NWrSOmpWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFntXZNKSzVyPUGxOE4{KG6P MYjTRW5ITVJ?
NCI-H1770 NGTC[opIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjIbXY2UUN3ME2xNlMvQDZibl2= NH7nRXJUSU6JRWK=
HuO9 NYK5VGV{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFf1NGlKSzVyPUKwOk4xOiCwTR?= NYjsbHprW0GQR1XS
HAL-01 Mlr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fk[GlEPTB;MkC2Mlc{KG6P MoDPV2FPT0WU
NOS-1 M3[zUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHXXJpTUUN3ME2yNVEvQDJibl2= NXXxdlB3W0GQR1XS
HGC-27 M4Hscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTJzMj61O{BvVQ>? Mn3CV2FPT0WU
NB69 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTJ2NT6yO{BvVQ>? M2DROXNCVkeHUh?=
RS4-11 NHrFO21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jjb2lEPTB;Mk[xMlc3KG6P MkXxV2FPT0WU
DOK Ml\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXwTWM2OD1|MEGuO{BvVQ>? M3ezcHNCVkeHUh?=
LB2241-RCC MoHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;JSWlEPTB;M{CzMlg1KG6P MV;TRW5ITVJ?
NCI-H1623 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTNyND6wPEBvVQ>? MVXTRW5ITVJ?
YH-13 M3TjRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;GTWM2OD1|MESuN|Ihdk1? MVrTRW5ITVJ?
BPH-1 M{j0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml6xTWM2OD1|MUSgcm0> M2TsSnNCVkeHUh?=
AN3-CA NFO4U49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTN2MD6zO{BvVQ>? MWXTRW5ITVJ?
ES7 M2HuUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHwTWM2OD1|NEGuPVkhdk1? NEjyW5JUSU6JRWK=
MDA-MB-175-VII MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvaZ2FKSzVyPUO1Nk46OiCwTR?= MmOzV2FPT0WU
GAMG NX7ZUFl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\ybYdKSzVyPUO3NE45PSCwTR?= MVTTRW5ITVJ?
CHL-1 NX3rR|BLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\wOod{UUN3ME2zO|gvPjVibl2= MX;TRW5ITVJ?
NB7 NV62c2NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVK0UZBGUUN3ME2zPFkvQDNibl2= NHmxUI9USU6JRWK=
MFE-280 M1vBbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLiTWM2OD12MUiuNkBvVQ>? M2\xRnNCVkeHUh?=
HL-60 NWnnemVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPlTWM2OD12MkWuO|Uhdk1? MUPTRW5ITVJ?
GCIY NXLHfmJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTR|Mz64JI5O NEHSXpZUSU6JRWK=
MDA-MB-361 NXPZbXF3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fUN2lEPTB;NEO5MlE{KG6P MnLsV2FPT0WU
LXF-289 M3zFZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DNW2lEPTB;NES4MlI4KG6P NIHG[WxUSU6JRWK=
NBsusSR NWHidplHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTuPHhKSzVyPUS4PE45PSCwTR?= MYnTRW5ITVJ?
KU-19-19 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfTe3FkUUN3ME21NVYvODdibl2= MXHTRW5ITVJ?
A204 MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPmTWM2OD13MkKuN|Mhdk1? M4\aPXNCVkeHUh?=
LB1047-RCC Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPxbot4UUN3ME21NlIvQTNibl2= MX7TRW5ITVJ?
COLO-684 MmTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzpXJVKSzVyPUWyN{4yOSCwTR?= MYHTRW5ITVJ?
PA-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jLT2lEPTB;NUOyMlQyKG6P NX3NN5VuW0GQR1XS
MG-63 NYPRcphPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTV2MT6xNUBvVQ>? MXrTRW5ITVJ?
BHT-101 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDqTWM2OD13NESuPVQhdk1? M2D6XnNCVkeHUh?=
NKM-1 NVzFdo04T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3nfG1iUUN3ME21PVMvODlibl2= MUTTRW5ITVJ?
T47D NX\u[ZJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfDRWhKSzVyPUW5O{42PiCwTR?= NH;PeFFUSU6JRWK=
MOLT-4 NWLBUIk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rmWWlEPTB;NkKzMlYzKG6P NX\MT2FWW0GQR1XS
IGROV-1 NGWwWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jlZWlEPTB;NkO0MlMyKG6P MX;TRW5ITVJ?
ES4 M{nhcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTZ|OT61OEBvVQ>? NEDoO4RUSU6JRWK=
HuO-3N1 M{HWUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jETmlEPTB;NkSyMlM5KG6P NIOyNo1USU6JRWK=
NEC8 NYSxV2NxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTZ3Mz61O{BvVQ>? MnHnV2FPT0WU
HO-1-N-1 MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXQem1KSzVyPU[1PU4yPyCwTR?= NF\wTlZUSU6JRWK=
EPCL-272H NYPHepJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELnfW5KSzVyPU[4O{4zOSCwTR?= NV;hXohDW0GQR1XS
D-263MG NH;keFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor2TWM2OD15MUiuNUBvVQ>? MVjTRW5ITVJ?
MV-4-11 MoPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrQZnVrUUN3ME23NlQvOzFibl2= M4PUSnNCVkeHUh?=
SK-NEP-1 NH:3SmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTd{NT65OEBvVQ>? Moj3V2FPT0WU
SW872 MnXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTd{Nz64PUBvVQ>? MVjTRW5ITVJ?
P30-OHK M1\6VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHWxXGdKSzVyPUezNE44OSCwTR?= MYXTRW5ITVJ?
OMC-1 NFHTWoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTd3MT6wPUBvVQ>? NVG5dnBLW0GQR1XS
LoVo NXf4fGZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{To[WlEPTB;N{e3Mlkhdk1? M2DOTHNCVkeHUh?=
LNCaP-Clone-FGC M{DndWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PsRmlEPTB;N{m2MlM1KG6P NWTEephYW0GQR1XS
L-363 M2PTRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPTRmY3UUN3ME23PVgvPDJibl2= M3TMVHNCVkeHUh?=
ES8 NIfDdoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRThzMD61NkBvVQ>? MV7TRW5ITVJ?
697 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTh|MT61OUBvVQ>? M1LW[XNCVkeHUh?=
HSC-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XZbWlEPTB;OEO5MlU1KG6P MVjTRW5ITVJ?
H4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH23XoRKSzVyPUi1NE45PSCwTR?= MXPTRW5ITVJ?
QIMR-WIL MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1H3emlEPTB;OE[1MlIhdk1? NHfSXnBUSU6JRWK=
OAW-42 M4fiNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTh5Mj6xPUBvVQ>? MWPTRW5ITVJ?
MCF7 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnmOW9iUUN3ME24PVgvPTlibl2= M1fNXnNCVkeHUh?=
SCC-25 MnLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fYSGlEPTB;OUG0MlE6KG6P MYrTRW5ITVJ?
NCI-H1563 NWHrcJBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknZTWM2OD17MUWuPVkhdk1? NETtdndUSU6JRWK=
OVCAR-5 MkXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTl2MD6xO{BvVQ>? MlvlV2FPT0WU
HDLM-2 MlvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3GfYRQUUN3ME25OFkvOiCwTR?= M13BSnNCVkeHUh?=
NB5 MlvGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\zTWM2OD17NU[uOkBvVQ>? MWHTRW5ITVJ?
NCI-H292 NITwUXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPyR3BHUUN3ME25O|QvOzJibl2= MUjTRW5ITVJ?
A101D NGL5ZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTSWWJKSzVyPUm5NE4yQSCwTR?= MoTOV2FPT0WU
NCI-H1648 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:3PI97UUN3ME25PVgvPTFibl2= Ml75V2FPT0WU
EKVX NX61bHJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TafmlEPTB;MT6wNVI6KM7:TR?= MnHOV2FPT0WU
SW1710 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFwMESyN|Mh|ryP M2PEPHNCVkeHUh?=
WM-115 M1j5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFwME[2OVYh|ryP MYLTRW5ITVJ?
CAL-54 NIXI[FFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zKZmlEPTB;MT6wO|A5OSEQvF2= Mnz2V2FPT0WU
TGBC24TKB M3jKSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL5PZFKSzVyPUGuNFgxPDVizszN NIfPc2VUSU6JRWK=
NCI-H520 M136Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS5TWM2OD1zLkC4PVY4KM7:TR?= NGjkWZdUSU6JRWK=
D-423MG NGT2RmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDCVJpKSzVyPUGuNFk6PjJizszN NFfB[JpUSU6JRWK=
BFTC-905 Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfCTWM2OD1zLkGzOFQ6KM7:TR?= NUmzfmxmW0GQR1XS
HT NGL1[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jkcmlEPTB;MT6xN|Q4QCEQvF2= NID6WVlUSU6JRWK=
CTB-1 NUW3eXFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDKOWZKSzVyPUGuNVQzQTNizszN M1XRTHNCVkeHUh?=
Hs-578-T NU[ybFR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFWyOFJKSzVyPUGuNVk2PjVizszN M1P3[HNCVkeHUh?=
HuH-7 NXewPYRnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\yenZKSzVyPUGuNlA6PDlizszN MYHTRW5ITVJ?
LB996-RCC NEXSeGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTFwMkKxO|ch|ryP M{Phd3NCVkeHUh?=
KYSE-270 NGTHUVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3vTWM2OD1zLkK5O|M1KM7:TR?= NIPlT|hUSU6JRWK=
A4-Fuk M2H3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP0dXg3UUN3ME2xMlI6QTl|IN88US=> NEXXeHZUSU6JRWK=
A498 NF;IV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPMTWM2OD1zLkOwOFc1KM7:TR?= MkHoV2FPT0WU
SK-MEL-1 M4\BT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHkTWM2OD1zLkOwOlc6KM7:TR?= NGXJTZhUSU6JRWK=
AU565 NYjlb3hIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjpcW0zUUN3ME2xMlMyQDZ|IN88US=> M3\oWHNCVkeHUh?=
Saos-2 NIrhfG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLuTWM2OD1zLkOzNlA2KM7:TR?= MnzNV2FPT0WU
A549 NH:1OYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTreWNiUUN3ME2xMlM6QTdizszN M3;rb3NCVkeHUh?=
BFTC-909 M{GzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTFwNEOzNFUh|ryP Mk\nV2FPT0WU
MDA-MB-415 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTFwNEi2PVIh|ryP NVG1c|VEW0GQR1XS
639-V MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DnfGlEPTB;MT61NFI1PSEQvF2= NYDWOm9qW0GQR1XS
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PANC-03-27 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXXTWdEUUN3ME2xMlUyPDB6IN88US=> NXz0TmNGW0GQR1XS
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LB771-HNC MoTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jPfmlEPTB;MU[uOFQzOiEQvF2= M2nzU3NCVkeHUh?=
SF268 MmjiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojoTWM2OD1zNj60OVIh|ryP M2D2N3NCVkeHUh?=
OE19 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTF4LkWyOEDPxE1? MoTNV2FPT0WU
MLMA NXP1V49nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXMUYoxUUN3ME2xOk42PTdzIN88US=> MYLTRW5ITVJ?
MDA-MB-231 NWDHeWdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;uTWM2OD1zNj63NVM3KM7:TR?= MVzTRW5ITVJ?
TGW MnPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX3RXRKSzVyPUG2MlgyODJizszN MlL0V2FPT0WU
MDA-MB-453 NWT0NJN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELBcJBKSzVyPUG3MlAxODNizszN MWfTRW5ITVJ?
SNU-C2B Mn7CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTF5LkCyN|ch|ryP NGjJSY5USU6JRWK=
A427 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlm3TWM2OD1zNz6yN|M1KM7:TR?= M1XYRXNCVkeHUh?=
SK-MEL-2 NULFR28{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzMTWM2OD1zNz6zNlE{KM7:TR?= M3PIc3NCVkeHUh?=
KURAMOCHI NHLpVGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF5LkO4PVch|ryP MVjTRW5ITVJ?
IST-MEL1 NWfPPXBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr4b5NKSzVyPUG3MlkyQDJizszN NHzWNppUSU6JRWK=
NCI-H1793 M3fRZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\1SYxHUUN3ME2xPE4yPThzIN88US=> NF7YTXNUSU6JRWK=
HCC1395 NXLENpg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVf5eWNsUUN3ME2xPE42PjFzIN88US=> MWHTRW5ITVJ?
NUGC-3 Mn;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTF6Lk[1PFQh|ryP MUPTRW5ITVJ?
BB65-RCC M370PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe1Rlh1UUN3ME2xPE43PjlizszN M1O5eXNCVkeHUh?=
RMG-I NFKyWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLBN4pKSzVyPUG4Mlc{QDJizszN M4P4Z3NCVkeHUh?=
LS-513 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLZXI84UUN3ME2xPE46OjJ6IN88US=> M3HCNHNCVkeHUh?=
MFM-223 NVzUSFhMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[yWHpKSzVyPUG5MlA4OTZizszN NHfS[JlUSU6JRWK=
NCI-H727 MoTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLkTWM2OD1zOT6zNlk2KM7:TR?= M4HYeHNCVkeHUh?=
KP-4 Mlf2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrTTWM2OD1zOT64OVMyKM7:TR?= MX7TRW5ITVJ?
NB13 NVHCe2tPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTMemZsUUN3ME2xPU45QDN7IN88US=> NX7lUHozW0GQR1XS
UACC-893 NGLCZ2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDYc|UxUUN3ME2xPU46PzV5IN88US=> MUfTRW5ITVJ?
HT-1197 NHvIOZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTJyLkK5OVgh|ryP NVuxWGpMW0GQR1XS
NCI-H2029 M1nrbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[zTWM2OD1{MD6zNlY3KM7:TR?= MYfTRW5ITVJ?
GI-ME-N M3\Qe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XJVWlEPTB;MkCuN|M4OyEQvF2= M2HSS3NCVkeHUh?=
OVCAR-3 M1TTNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP3TWM2OD1{MD61PFIzKM7:TR?= M2jQSHNCVkeHUh?=
HD-MY-Z NXP3cIRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LuSGlEPTB;MkGuN|Y6PiEQvF2= NWPRO41QW0GQR1XS
NTERA-S-cl-D1 MoLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTJzLk[3NlIh|ryP NW\WcYd6W0GQR1XS
SCH NGXsZo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjIUZdKSzVyPUKyMlQ6PiEQvF2= Mkj0V2FPT0WU
KARPAS-299 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfNc|BOUUN3ME2yN{4{QDh5IN88US=> MY\TRW5ITVJ?
NCI-H1650 M4\rS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3UNINKSzVyPUKzMlkzPDFizszN M4Huc3NCVkeHUh?=
ACHN M1HNOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHvVodbUUN3ME2yOE41PjV4IN88US=> MVrTRW5ITVJ?
M059J NIThPZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vuN2lEPTB;MkSuOVY{PCEQvF2= NW\iZ4ltW0GQR1XS
AM-38 NXfZVoNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\LbWVKSzVyPUK1MlQ5OSEQvF2= NHLkNIFUSU6JRWK=
KG-1 NXHyVYpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TkUGlEPTB;MkWuOVQ6PCEQvF2= M3vJV3NCVkeHUh?=
COLO-824 NYnhSIc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnK0TWM2OD1{NT61OVk6KM7:TR?= NYXkPZNmW0GQR1XS
NCI-H1155 NFHCboJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfMTWM2OD1{NT61PFQ4KM7:TR?= NELJXWFUSU6JRWK=
NCI-H441 NXrOSXRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLGTWM2OD1{NT63OFY2KM7:TR?= NGjlZmJUSU6JRWK=
J-RT3-T3-5 MnTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzOXJlKSzVyPUK2MlMxOjdizszN M4XHeXNCVkeHUh?=
JEG-3 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTJ4Lk[4NFUh|ryP MljvV2FPT0WU
RKO NGjjOlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\Gd3VKSzVyPUK2Mlc3OzJizszN MYfTRW5ITVJ?
CAL-85-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnO3TWM2OD1{Nz6yNVE5KM7:TR?= MWTTRW5ITVJ?
CAL-120 MnX0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nFSmlEPTB;MkeuOlkyPCEQvF2= MkSwV2FPT0WU
NCI-H2452 NV\5UWpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfvXWM2UUN3ME2yO{44PzF4IN88US=> NWniemJsW0GQR1XS
NCI-H1395 M{\2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTtTWM2OD1{Nz63PFM{KM7:TR?= NUPUNnY6W0GQR1XS
KYSE-450 MlPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTJ5Lkm4OlIh|ryP NVPsRoNSW0GQR1XS
S-117 NFPTfnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjSWWVKUUN3ME2yPU4{QDV5IN88US=> M4Kwb3NCVkeHUh?=
SW13 MkfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\5WHVKSzVyPUK5Mlg2OTlizszN NELBdoRUSU6JRWK=
ES3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jBfWlEPTB;M{CuN|c{OyEQvF2= Mn22V2FPT0WU
HCT-116 NXPZS5E6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTNyLkW1OVQh|ryP MVjTRW5ITVJ?
NCI-H1693 MknwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfpTWM2OD1|MD61PVQzKM7:TR?= NYK0VpF2W0GQR1XS
VM-CUB-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHvTWM2OD1|MD62OFE{KM7:TR?= MYjTRW5ITVJ?
NCI-H2170 M1;SXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETQTG1KSzVyPUOxMlU4QDRizszN MWPTRW5ITVJ?
ALL-PO NILGfYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7STphKSzVyPUOxMlg1OjhizszN M33vWXNCVkeHUh?=
NCI-H661 Mn72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfITWM2OD1|Mj6wOlI{KM7:TR?= MXPTRW5ITVJ?
NCI-H2347 NYXqU3VXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTN{LkS4N|ch|ryP M1e0R3NCVkeHUh?=
FTC-133 M1rCfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fBdWlEPTB;M{KuO|A3KM7:TR?= NUjZZXV[W0GQR1XS
COLO-829 NVL1fY4yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnPcGRsUUN3ME2zN{4{PDZ5IN88US=> NE\QVXZUSU6JRWK=
GOTO MnnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHrTWM2OD1|Mz61NlU5KM7:TR?= M2HI[XNCVkeHUh?=
YAPC NY\oOZFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37l[WlEPTB;M{OuPFE2QSEQvF2= NYjncFZyW0GQR1XS
LCLC-103H NXHBSnppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3BTWM2OD1|ND6xOlI1KM7:TR?= MojZV2FPT0WU
SiHa MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3QW3FKSzVyPUO0MlM5OTdizszN MYfTRW5ITVJ?
LK-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjUTWM2OD1|ND61O|A5KM7:TR?= MoHSV2FPT0WU
KP-N-YS M3jZS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTN2LkeyNFIh|ryP Ml7IV2FPT0WU
NCI-SNU-1 M4iyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXPTmlKSzVyPUO1MlE4QSEQvF2= MmDuV2FPT0WU
KNS-81-FD M{XENWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnpdJdUUUN3ME2zOU43PjNizszN MYHTRW5ITVJ?
SCC-9 NGj3S41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DTNmlEPTB;M{[uO|E1PiEQvF2= NFzDS|lUSU6JRWK=
SH-4 Mk\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\3ZoRWUUN3ME2zOk44OyEQvF2= NWL3O3hIW0GQR1XS
HCC-1954 NG\xfVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHESVZKSzVyPUO3MlI4OjlizszN MojPV2FPT0WU
BALL-1 NU\WR|BUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTLTWM2OD1|Nz61N|E3KM7:TR?= MoTEV2FPT0WU
BE-13 MkXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTLTWM2OD1|Nz63NFE5KM7:TR?= NWXX[m84W0GQR1XS
COLO-678 Mm\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjtTWM2OD1|Nz65OFM4KM7:TR?= MkHVV2FPT0WU
SK-MEL-3 NX7yeHRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLJTWM2OD1|OD6yN|k4KM7:TR?= M1PHXnNCVkeHUh?=
OAW-28 M331SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTN6Lk[zPUDPxE1? M4XF[HNCVkeHUh?=
CAMA-1 NIr3OIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3i3NWlEPTB;M{iuPVY6OSEQvF2= NVuyTlJWW0GQR1XS
C2BBe1 NIPHeVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\FTWM2OD1|OT64NVgh|ryP M3i3c3NCVkeHUh?=
A3-KAW MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfMTWM2OD12MD6zOlYyKM7:TR?= NF61[HdUSU6JRWK=
SK-MEL-24 M1PlRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LXcmlEPTB;NECuOVk{OSEQvF2= Mo\rV2FPT0WU
KYSE-140 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXWTWM2OD12MD63NVY2KM7:TR?= MlfDV2FPT0WU
MOLT-16 M3y5TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXj1SI5XUUN3ME20NU4yPTN4IN88US=> NF\KfplUSU6JRWK=
CFPAC-1 M{jaWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTR{LkWyNVEh|ryP M4TqWnNCVkeHUh?=
NB14 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfkTHRKSzVyPUSyMlcxOjdizszN NFXCZ25USU6JRWK=
COLO-792 MmjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn6TWM2OD12Mj64PVYyKM7:TR?= MlWxV2FPT0WU
RH-1 NGTBO5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrIVHJ4UUN3ME20N{41QDN4IN88US=> NULCSIRIW0GQR1XS
NCI-H522 NGDNO|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXqTWM2OD12ND6zOVY5KM7:TR?= NYmy[4R2W0GQR1XS
Ca-Ski NHS4[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1v0N2lEPTB;NESuPFEyPCEQvF2= NG\YSJRUSU6JRWK=
KGN NE[1fFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;ETWM2OD12OD6zNFY{KM7:TR?= MWfTRW5ITVJ?
UACC-62 NF3jW41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\BPWlEPTB;NEiuOFA4OiEQvF2= MXnTRW5ITVJ?
NCI-H358 NXvGZXE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XEOmlEPTB;NEmuN|AyQCEQvF2= MmHuV2FPT0WU
LS-411N M2fqWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3XNFJKSzVyPUS5MlMyOThizszN MU\TRW5ITVJ?
IST-MES1 NYixdI1FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XhbmlEPTB;NEmuOVYzPSEQvF2= NULHT2hYW0GQR1XS

... Click to View More Cell Line Experimental Data

体内研究 在微粒体中,GDC-0941仅有有限的代谢,其口服生物利用度为78%[5]。GDC-0941 每天按 75 mg/kg剂量处理携带人U87MG 恶性胶质移植瘤的雌性NCr无胸腺小鼠,显著抑制生长,肿瘤生长抑制率为 83%。[1]GDC-0941 每天按 150 mg/kg剂量口服处理携带HER2扩增的抗Trastuzumab的MDA-MB-361.1移植瘤 的小鼠,抑制肿瘤生长,且显著延迟肿瘤衰退,与肿瘤中强诱导型凋亡相关。[2] GDC-0941 每天按75 mg/kg剂量处理携带自发性B细胞滤泡性淋巴瘤的PTEN+/-LKB1+/hypo小鼠,持续2周,诱导肿瘤体积下降~40%,伴随着AKT, S6K 和SGK(血清和糖皮质激素蛋白激酶)蛋白激酶的磷酸化被切除。GDC-0941抑制肿瘤细胞增殖,诱导凋亡和抑制中心母细胞数。[3]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

闪烁接近检测:

使用p85α调节亚基,使重组人PI3Kα, PI3Kβ, 和PI3Kδ在 Sf9 杆状病毒系统中共表达,在谷胱甘肽-琼脂糖凝胶上进行亲和层析而纯化GST-融合蛋白。重组人 PI3Kγ表达作为单体 GST融合,也想上述相似方法纯化。GDC-0941 溶于DMSO,加到含200 μg硅酸钇(Ysi) 聚赖氨酸SPA 磁珠, 4 mM MgCl2, 1 mM 二硫苏糖醇 (DTT), 1 μM ATP, 0.125 μCi [γ-33P]-ATP, 和4% (v/v) DMSO的20 mM Tris-HCl (pH 7.5)上,总体积为 50 μL。PI3Kα (5 ng), PI3Kβ(5 ng), PI3Kδ(5 ng), 或PI3Kγ(5 ng)的重组GST-融合 ,加到实验混合物中,开始激酶反应。在室温下温育1小时后, 加入150 μL PBS终止反应。混合物在2000 rpm 转速下离心2分钟,然后使用Wallac Microbeta计数器读数。在 MDL Assay Explorer系统中使用S型,剂量-反应曲线,计算进行至少2次独立重复实验,取平均值,作为IC50值。
细胞实验:

[2]

+ 展开
  • Cell lines: SKBR-3, BT474-M1, AU-565, HCC-1419, ZR75-30, KPL-4, JIMT-1, BT474-EEI, HCC-1954, MCF-7, CALU-3, SKOV-3, 和MKN-7
  • Concentrations: 溶于DMSO,终浓度为~10 μM
  • Incubation Time: 48,和72小时
  • Method:

    使用不同浓度 GDC-0941处理细胞48,和 72小时。通过CellTiter-Glo Luminescent细胞活性检测实验测定细胞增殖/活力。通过Western Blot分析pAKT (Ser473), cleaved caspase-3, 和cleaved PARP通过 Caspase-Glo 3/7实验和细胞死亡检测 ELISAplus 实验分别测定caspase 3/7活性, 和凋亡。


    (Only for Reference)
动物实验:

[2]

+ 展开
  • Animal Models: 移植MDA-MB-361.1细胞的NCR裸鼠, 皮下移植BT474-M1 细胞的SCID, C.B-17/IcrHsd-Prkdcscid 小鼠
  • Formulation: 溶于10% DMSO, 5% Tween-20, 85% 水
  • Dosages: ~150 mg/kg/day
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 44 mg/mL (85.66 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
2% DMSO+30% PEG 300+5% Tween 80+ddH2O
5mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 513.64
化学式

C23H27N7O3S2

CAS号 957054-30-7
稳定性 powder
in solvent
别名 RG7321

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01740336 Completed Breast Cancer Genentech Inc. February 6 2013 Phase 2
NCT00999128 Completed Healthy Volunteers Genentech Inc. October 26 2009 Phase 1
NCT02092831 Completed Healthy Volunteer Genentech Inc. April 2014 Phase 1
NCT01474668 Completed Healthy Volunteer Genentech Inc. October 2011 Phase 1
NCT01437566 Completed Breast Cancer Genentech Inc. October 2011 Phase 2
NCT01240226 Completed Healthy Volunteer Genentech Inc. November 2010 Phase 1

技术支持

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操作手册

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID