MK-2206 2HCl

目录号:S1078

MK-2206 2HCl Chemical Structure

Molecular Weight(MW): 480.39

MK-2206 2HCl是一种高度选择性的Akt1/2/3抑制剂,在无细胞试验中IC50分别为8 nM/12 nM/65 nM;对250种其他蛋白激酶没有抑制活性。Phase 2。

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客户购买Selleck的此次产品后发表的文献180篇:

客户使用该产品的19个实验数据:

  • Inhibition of AKT signaling abolishes MKK4 phosphorylation on Ser78 in injured axons. Cultures of sensory neurons were treated with 5 µM MK-2206 or 5 µM GDC-0068 for 1 hr prior to axotomy. Axonal proteins harvested at indicated time points after axotomy were subjected to immunoblot analysis.

    Cell, 2015, 160(1-2): 161-76 . MK-2206 2HCl purchased from Selleck.

    Cancer Cell 2013 24, 766-76. MK-2206 2HCl purchased from Selleck.

  • The PI3K or AKT inhibition does not restore sensitivity to WZ4002 in PC9 WZR. PC9GR4 or WZR10 cells were treated with WZ4002 alone at the indicated concentrations or in combination with the AKT inhibitor MK-2206 (1 uM). MK-2206 effectively inhibited AKT in both cells.

    Cancer Discov 2012 2, 934-47. MK-2206 2HCl purchased from Selleck.

    Rap1b negatively regulates neutrophil transcellular migration by limiting PI3K-Akt signaling. (A-D) Effect of Akt inhibitor MK2206 (2 uM), Src inhibitor PP2 (10 uM), or vehicle control (DMSO) on WT or Rap1b-/- neutrophil functions. (A) Percentage of neutrophil transendothelial migration in 3D migration model. (B) ECM degradation assessed on Oregon green-labeled gelatin matrix; (left) representative images on (bar, 10 um) and (right) bar graph is percentage of matrix degradation. (C) Percentage of cells forming multiple protrusions. (D) Percentage of neutrophils present at junction of activated bEND.3 in 3D migration assay. Mean ?SD; n = 3 independent experiments. **, P < 0.01; ***, P < 0.001; NS, not significant using unpaired Student's t test).

    J Exp Med 2014 211(9), 1741-58. MK-2206 2HCl purchased from Selleck.

  • VE-cadherin-induced Akt activation mediates YAP phosphorylation and translocation in ECs. HUVECs were starved for 1h and treated with thrombin (1U) for 1h. Total cell lysates were probed with anti-pAkt, Akt or b-actin antibody. The representative blots of three independent experiments are depicted, and the normalized values for p-Akt are shown. HUVECs were cultured and starved as described as in d and incubated for 8h in complete medium with the Akt inhibitor, MK-2206 (1 uM). pAkt, Akt, pYAP and YAP were detected by western blotting using specific antibodies.

    Nat Commun 2015 6:6943. MK-2206 2HCl purchased from Selleck.

    Inhibitors of AKT or ERK overcome SDF-1a-mediated resistance to ibrutinib-triggered PARP and caspase 3 cleavage in CXCR4S338X-expressing BCWM.1 cells. CXCR4S338X-expressing WM cells were treated with ibrutinib (0.5 uM) alone or in the presence of SDF-1a (20 nM) and/or the AKT inhibitors MK-2206 (0.5 uM) and AZD-5363 (0.5 uM); or the MEK inhibitors AS-703026 (0.25 uM), AZD-6244 (0.5 uM) and UO126 (5.0 uM). (a) Immunoblotting results for phosphoAKT (S473) and phospho-ERK (T202/Y204) in CXCR4S338X-expressing BCWM.1 cells pretreated with ibrutinib with and without AKT or ERK inhibitors, then subjected to SDF-1a stimulation for 2 min. The inhibitory effect of AZD-5363 on AKT, which is known to paradoxically hyper-phosphorylate pAKT(S473) was confirmed by inhibition of the phospho-activity for the downstream AKT targets glycogen synthase kinase 3b and pS6. (b) Immunoblotting results for cleaved PARP and cleaved caspase 3 in CXCR4S338X-expressing BCWM.1 cells treated with ibrutinib and/or AKT or ERK inhibitors for 6 h at IC50 doses. GAPDH, glyceraldehyde 3-phosphate dehydrogenase.

    Leukemia 2015 29(1), 169-76. MK-2206 2HCl purchased from Selleck.

  • Induction of apoptosis positively correlates with FOXO3a protein levels and phosphorylation. (a) Treatment of 11 cell lines seeded in 6-well plates with 8 μM MK-2206 or DMSO for 48 hours. Nuclei were harvested for PI staining and FACS analysis and the differences between drug and no drug are displayed as in Figure b. Both conditions were performed in triplo for each cell line. Below the FACS data is a we stern blot of cell lysates from this panel treated with 8 μM MK-2206 or DMSO and harvested at 24 hours. Each cell line name corresponds to the two western lanes below it and the four cell cycle bars above it.

    Cancer Res 2013 73, 2189-98. MK-2206 2HCl purchased from Selleck.

    IC50 values for an Akt inhibitor (MK-2206) and a MEK inhibitor (U0126) in a panel of mouse and human anaplastic (ATC) and follicular (FTC) carcinoma cell lines. On the bottom, a Western blotting showing the effect on the activation of Akt and ERK1/2 of one hour exposure to these inhibitors (MK-2206: 500 nM, U0126: 10 μM).

    Oncotarget 2011 2, 1109-26. MK-2206 2HCl purchased from Selleck.

  • Mean IL-8 concentrations determined by ELISA of the supernatants of HeLa cells infected with wild-type Salmonella. Kinase inhibitors are indicated on the x axis, and the target families of the inhibitors are indicated above each column. CEC, chelerythrine; Pim Inh, Pim-1 inhibitor 2. Inhibitors that significantly affected IL-8 production relative to the control (P < 0.05, Bonferroni post hoc test from one-way ANOVA) are indicated with an asterisk. Relative cell viability is also shown, as determined by reduction of XTT by viable cells. A450, absorbance at 450 nm.

    Sci Signal 2011 4, rs9. MK-2206 2HCl purchased from Selleck.

    Reducing cellular levels of PtdIns5P by overexpression of PIP4Kα inhibits clonogenic growth of U2OS but enhances cell survival in response to H2O2 stimulation. A) U2OS cells (1000) were plated, allowed to attach overnight, and then treated with DMSO (control), PI-103 (0.5 μM), U0126 (5 μM), or SB203580 (5 μM) for 9 d. Cell colonies were stained using crystal violet. Dried plates were scanned. Representative results are shown. B) U2OS cells (1000) were plated, allowed to attach overnight, and then treated with DMSO (control), MK-2206 (1 μM), triciribine (1 μM), KU0063794 (1 μM), or PI-103 (0.5 μM) for 9 d. Cell colonies were stained using crystal violet. Dried plates were scanned. Representative results are shown.

    FASEB J 2013 27, 1644-56. MK-2206 2HCl purchased from Selleck.

  • A. Western blot analysis of pAKT activation in ovarian cancer cell lines treated with exogenous IGF-1. B. Activation of pAKT by IGF-1 in low-grade ovarian cancer cell lines was blocked by the AKT inhibitor MK-2206 in a dose-dependent manner.

    Gynecol Oncol 2011 123, 13-8. MK-2206 2HCl purchased from Selleck.

    Confocal microscopy images of NO formation. DAF 2 DA-loaded washed platelets (1.0109 platelets/mL) were preincubated at 378C with saline (A), and then stimulated for 1min with 0.1 (B), 1.0 (C) or 10 (D) μM AEA. In Panel (E-F-G) washed platelets were preincubated with 1 μM SR1 (E), 1 Mm MK2206 (F) or 20 μM LY294002 (G), and then stimulated for 1min with 1.0 μM AEA. In panel (H) is reported the effect of 5 mg/mL collagen, used as a positive control. All the experiments were carried out in the presence of 100 μM L-arginine. NO formation was visualized by confocal microscropy as detailed in Methods.

     

     

    J Cell Biochem 2011 112, 924–932. MK-2206 2HCl purchased from Selleck.

  • The AEA effect on eNOS phosphorylation. Washed platelets (1.0109 platelets/mL), preincubated at 378C with saline, 1 μM SR1, 1 μM SR2, 20 μM LY294002, 1 μM MK2206, 1.0 μM EGTA, or 30 μM BAPTA/AM, were stimulated for 1 min with 1.0 μM AEA. At the end of incubation suitable aliquots were immunoblotted with anti-p-eNOSser1177 as detailed in Methods.Blots are representative of five independent experiments.

     

     

    J Cell Biochem 2011 112, 924–932. MK-2206 2HCl purchased from Selleck.

    Effect of selected agents on NOx and cGMP formation induced by AEA. Washed platelets (1.0109 platelets/mL), prewarmed at 378C with saline or 1mM SR1, 1 μM SR2, 20 μM URB597 (URB), 1 μM MK2206 (MK) or 20 μM LY294002 (LY), were incubated for 1min with 100 μM L-arginine in the presence of 1.0 μM AEA. NOx (panel A) and cGMP (panel B) content were determined as detailed in Methods. Each bar represents the meanSD of five independent experiments carried out in triplicate. Student,s t-test: P <0.0001 versus none;P <0.0005; P <0.005 versus AEA

     

     

    J Cell Biochem 2011 112, 924–932. MK-2206 2HCl purchased from Selleck.

  • C.U87MG cells were treated with vehicle or 1 μM MK-2206 for 1 hr, and then irradiated with 6 Gy. Total cell lysate was harvested 1 hr after IR and subjected to Western blot analysis with the indicated antibody. Cells without IR treatment were used as a control.

    D. Cells were treated with vehicle (control) or 1 μM MK-2206 for 1 hr, then irradiated with indicated dosage. 4 hr after IR, cells were fed with drug-free medium, and incubated for another 20 hr at 37°C, after which they were trypsinized and seeded for clonogenic survival assay. Colony-forming efficiency was determined 14 d later.
     

     

    Radiat Oncol 2009 4, 43. MK-2206 2HCl purchased from Selleck.

    MK-2206 2HCL inhibited the sorafenib-induced PI3K/mTOR pathway activation and enhanced the cytotoxic effects of sorafenib in resistant cell lines. (A) HUH-7 hepatoma cells treated with sorafenib (5 μM) for 24 h with or without pretreatment with specific kinase inhibitors (MK-2206 2HCL, 15 μM). The expressions of p-AKT and cleaved PARP were revealed by Western blotting. (B) SK-HEP-1 hepatoma cells treated with sorafenib (5 μM) for 24 h with or without pretreatment with specific kinase inhibitors (MK-2206 2HCL, 15 μM). The expressions of p-AKT and cleaved RARP were revealed by Western blotting. (C) HUH-7 hepatoma cells treated with sorafenib (5 μM) with or without the kinase inhibitors for 24 h. The proportions of apoptotic cells were evaluated by annexin V labeling. (D) SK-HEP-1 hepatoma cells treated with sorafenib (5 μM) with or without the kinase inhibitors for 24 h. The proportions of apoptotic cells were evaluated by annexin V labeling. (*P < 0.05, HUH-7, SK-HEP-1 are control groups, R-HUH-7, R-SK-HEP-1 are resistant groups).

    J Surg Res, 2016, 206(2):371-379. MK-2206 2HCl purchased from Selleck.

  • After starved in serum-free medium for 24h, Breast cancer cells incubated with the indicated concentrations of MK-2206 for 3h,followed by 15-minute stimolation of 100ng/ml EGF.

     
     

     

    Dr. Zhang of Tianjin Medical University. MK-2206 2HCl purchased from Selleck.

    Comparative effects of inhibitors by immunofluorescence microscopy study. Confluent HC11 cells were grown on poly-L-lysine-coated glass coverslips (immunofluorescence) and on plastic plates (biochemical control) and then treated with inhibitors according to the standard procedure. Upper part: the biochemical action of the inhibitors was tested to validate the immunofluorescence results. Cellular proteins were analyzed by SDS-PAGE and the immunoblots were successively probed with anti-ADRP, anti-β-casein, and anti- β-actin antibodies and their respective HRP-conjugated secondary antibodies. Each experimental condition was performed in duplicate. Lower part: cells were fixed, permeabilized and subjected to immunofluorescence microscopy using antiserum against ADRP and TRITC-conjugated secondary antibody (red).

    Biochim Biophys Acta 2012 1823, 987-96. MK-2206 2HCl purchased from Selleck.

  •  

    PI3K pathway signaling in GDC-0941 and MK-2206 treated MCF-7 derivatives with PIK3CA or  AKT1 mutations. Cells were grown in medium containing 5% FBS and treated with vehicle or increasing concentrations of GDC-0941 (0 nM, 50 nM, 100 nM, and 400 nM) or MK-2206 (0 nM, 100 nM, 250 nM, 1000 nM). After 24 hours of drug treatment, lysates were prepared and equal amounts of protein were load ed onto SDS-PAGE gels and blotted with the indicated antibodies.

    MK-2206 2HCl purchased from Selleck.

产品安全说明书

Akt抑制剂选择性比较

生物活性

产品描述 MK-2206 2HCl是一种高度选择性的Akt1/2/3抑制剂,在无细胞试验中IC50分别为8 nM/12 nM/65 nM;对250种其他蛋白激酶没有抑制活性。Phase 2。
特性 MK-2206是第一个进入临床研究阶段的Akt小分子变构抑制剂。
靶点
Akt1 [1]
(Cell-free assay)
Akt2 [1]
(Cell-free assay)
Akt3 [1]
(Cell-free assay)
8 nM 12 nM 65 nM
体外研究

MK-2206是变构抑制剂,由pleckstrin同源结构域激活。MK-2206抑制Akt的苏氨酸308位点和丝氨酸473位点的自身磷酸化作用。另外,MK-2206阻止Akt调节的下游信号分子(包括TSC2, PRAS40,及核糖体S6蛋白)的磷酸化作用。与抑制Ras 突变型细胞系(如NCI-H358, NCI-H23, NCI-H1299, 和Calu-6)相比,MK-2206 更有效地抑制Ras野生型细胞系(如A431, HCC827, 和NCI-H292)。MK-2206和细胞毒素药剂如erlotinib 和lapatinib联用作用于肺部NCI-H460肿瘤细胞或者卵巢A2780肿瘤细胞,MK-2206也显示出协同效应。[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
NCI-H292 MVLDfZRwfG:6aXOgRZN{[Xl? MYCzJO69VQ>? Mn7tO|IhcA>? MX\EUXNQ NET5XY1KdmirYnn0bY9vKG:oIHPlcIwheHKxbHnm[ZJifGmxbh?= MlL4NlA2PzFyNkm=
A431 MnfDT4lv[XOnIFHzd4F6 NUO1c2tqPSEQvF2= NWDUOGdzPSCq M4\UOWROW09? MljuV5VxeHKnc4Pld{B1cGVic3nncoFtcW6pIH;mJGFsfCCjbnSgSZJs MV:yNFU4OTB4OR?=
HepG2 MX;DfZRwfG:6aXOgRZN{[Xl? MX:xNEDPxE1? Mn\TNlQhcA>? NIDLeo1FVVOR MlvnV4Vve2m2aYrld{Bz\XOrc4ThcpQh[2WubIOgeI8hfGinIHP5eI91d3irYzDl[oZm[3Rib3[gd49z[W[nbnni M1rLTFIyOjB3OUK1
Sk-Hep1 M1L4SGN6fG:2b4jpZ{BCe3OjeR?= NHjaNXUyOCEQvF2= Mn\nNlQhcA>? MlvGSG1UVw>? NIW3ZYNU\W6|aYTpfoV{KHKnc3nzeIFvfCClZXzsd{B1dyC2aHWgZ5l1d3SxeHnjJIVn\mWldDDv[kB{d3KjZnXubYI> NGLsPHMzOTJyNUmyOS=>
OCUT1 cells harbored PIK3CA (H1047R+/+) NVvPSYx[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYqzJO69VQ>? NF;IZ5k2KGR? MVnEUXNQ MUfJR|UxRTBwMUSg{txO NHv5[HkzOTJ6OUK2Oy=>
K1 cells harbored PIK3CA (E542K+/+) MlTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfHN{DPxE1? NHmy[Xk2KGR? M4\K[mROW09? M3W1UGlEPTB;MD61NkDPxE1? NWmxN|NGOjF{OEmyOlc>
FTC133 cells harbored PTEN (allele deletion and R130+) MnvWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUOzJO69VQ>? NXfZRno6PSCm M4T6bGROW09? MYXJR|UxRTBwMUig{txO MXGyNVI5QTJ4Nx?=
C643 cells harbored HRAS (G13R+/−) MmrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1W0e|Mh|ryP NF3wZnM2KGR? MXzEUXNQ MWjJR|UxRTBwMkeg{txO M2fKZlIyOjh7Mk[3
Hth7 cells harbored NRAS (Q61R+/−) MlOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUCzdHBEOyEQvF2= MknkOUBl NFXk[lZFVVOR NIP3T4xKSzVyPUSuOUDPxE1? MVyyNVI5QTJ4Nx?=
TPC1 cells harbored RET/PTC1 rearrangement NX7WeFk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrT[o9ROyEQvF2= NEDDeJc2KGR? MnLqSG1UVw>? MWfJR|UxRTBwNUmg{txO NIS1SJYzOTJ6OUK2Oy=>
Hth74 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorTN{DPxE1? M4jmOlUh\A>? MV7EUXNQ NFXQZWZKSzVyPUKuNVkh|ryP NUK1SXd{OjF{OEmyOlc>
KAT18 M2ftO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXnZpVGOyEQvF2= M33xcVUh\A>? M{LPN2ROW09? Mlj0TWM2OD12Lk[yJO69VQ>? MnXJNlEzQDl{Nke=
SW1736 NUmycHpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3yNVAxKM7:TR?= MonOOUBl Mmf6SG1UVw>? NULVVnN1UUN3ME20O{42PiEQvF2= Ml3RNlEzQDl{Nke=
WRO MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH5NVAxOCEQvF2= NW\CPGVqPSCm NEfBdnpFVVOR MWjJR|UxRjFyMECg{txO NIfBZnozOTJ6OUK2Oy=>
TAD2 NWnaT5JwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVuxNFAxKM7:TR?= MYi1JIQ> MlrpSG1UVw>? M330e2lEPTB-MUCwNEDPxE1? MUmyNVI5QTJ4Nx?=
LN229 NGi5fWxCeG:ydH;zbZMhSXO|YYm= M{f6d|AvPSEQvF2= M4PuV|YxKGh? M{n5cWROW09? MlTmRZVodWWwdIOgZZBweHSxZ3XubYMh\W[oZXP0d{Bw\iCpZX\peIlvcWJ? Ml7mNlIxPTd7MUS=
T98G M2LTc2Fxd3C2b4Ppd{BCe3OjeR?= NIPwcGcxNjVizszN NHS0UVY3OCCq NU\Sc5pxTE2VTx?= MWnBeYdu\W62czDhdI9xfG:pZX7pZ{Bm\m[nY4TzJI9nKGenZnn0bY5q[g>? MnPFNlIxPTd7MUS=
HC11 M2HnS2Z2dmO2aX;uJGF{e2G7 NUPhPFM2OTBizszN MojiNlQhcA>? MonqSG1UVw>? NVn0XVBIUW6qaXLpeJMh|rJvY3Hz[YlvKGGwZDDBSHJRKHO7boTo[ZNqew>? MXmyNlQzPjZ{MR?=
MOLT-4 MXnDfZRwfG:6aXOgRZN{[Xl? NFHsUm8yOCEQvF2= NXG0TmRkPDhiaB?= NY\1T5ROTE2VTx?= NVrCWpFkUUN3ME2xMlfjiIoQvF2= M3GxTlIzPjF2MkSz
CEM-R NHz4U5dEgXSxdH;4bYMhSXO|YYm= M1jndVExKM7:TR?= NYTMS21pPDhiaB?= NUP6Z5JETE2VTx?= NVLjRY9xUUN3ME2zMlPjiIoQvF2= NGDuOnYzOjZzNEK0Ny=>
CEM-S M1Psc2N6fG:2b4jpZ{BCe3OjeR?= M3[3VVExKM7:TR?= MU[0PEBp Ml7JSG1UVw>? MkniTWM2OD13LkJihKnPxE1? NYHaUWJ2OjJ4MUSyOFM>
MOLT-4 MljLSpVv[3Srb36gRZN{[Xl? MXmxNEDPxE1? M4XZVVI1KGh? M4\xO2ROW09? NUK1cHZmSmyxY3vzJINmdGy|IHnuJJRp\SCJMD;HNUBxcGG|ZTDv[kB1cGViY3XscEBkgWOuZR?= MV[yNlYyPDJ2Mx?=
MOLT-4 MoHlSpVv[3Srb36gRZN{[Xl? M1j2VlTjiIoQvF2= MVG0JIg> MoC5SG1UVw>? Mo[5TY5kemWjc3XzJJRp\SCjbX;1cpQhd2ZiY3zlZZZm\CCOQ{PBM2ItKGFid3XscE1me3SjYnzpd4hm\CCjdYTvdIhi\3libXHyb4Vz MkXtNlI3OTR{NEO=
CEM-R MoXpSpVv[3Srb36gRZN{[Xl? NFn2WWg16oDLzszN MkTaOEBp NEfMOoVFVVOR MXTJcoNz\WG|ZYOgeIhmKGGvb4XueEBw\iClbHXheoVlKEyFNFGvRkwh[SC5ZXzsMYV{fGGkbHnzbIVlKGG3dH;wbIFogSCvYYLr[ZI> MUOyNlYyPDJ2Mx?=
CEM-S M{O0eGZ2dmO2aX;uJGF{e2G7 MVm05qCK|ryP MUW0JIg> M2T2TGROW09? M1zEbGlv[3KnYYPld{B1cGViYX3veY51KG:oIHPs[YF3\WRiTFO1RU9DNCCjIIflcIwu\XO2YXLsbZNp\WRiYYX0c5Bp[We7IH3hdotmeg>? M4K2cFIzPjF2MkSz
HepG2 cell NHKyOpNMcW6jc3WgRZN{[Xl? NH;SNoszOCEQvF2= MXeyOEBp NEPoR4RFVVOR NYfUc4dLTG:5boLl[5Vt[XSnczD0bIUheGixc4Doc5J6dGG2aX;uJI9nKEGNVB?= M3XsTVI{Pzl5M{G5
HepG2 cell MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVKzNEDPxE1? MXyyOEBp NITTdYJFVVOR MoO4TY5pcWKrdIOgZ4VtdCCpcn;3eIg> M3vNSFI{Pzl5M{G5
HepG2 cell MUnBdI9xfG:|aYOgRZN{[Xl? NHnWWJAzOCEQvF2= Mnj1NlQhcA>? M4DRbGROW09? NGTJbpFKdmS3Y3XzJINmdGxiYYDvdJRwe2m| MlLiNlM4QTd|MUm=
GEO NVH3dGxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjU[JU2ODBibl2= M3XINlczKGh? NXzoZ44xTE2VTx?= NVHn[nplUW6qaXLpeJMh[2WubDDndo94fGh? M2j2[VI1PThzMkOx
CNE-1 NVjK[GtQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYq4bIRVOTBizszN NEHzWVU6PiCq NYiwNHVrTE2VTx?= NHS1XG1KSzVyPUKuPVYh|ryP Mn;mNlU{OzZ7MkW=
CNE-2 NVHnXplUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYixNEDPxE1? MkH0PVYhcA>? NVL6boxYTE2VTx?= NX3EOpRWUUN3ME20MlU{KM7:TR?= NHm5TWEzPTN|NkmyOS=>
HONE-1 MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXrNVAh|ryP NHLW[XY6PiCq M3PtfmROW09? MoDNTWM2OD1|LkO3JO69VQ>? Mn;jNlU{OzZ7MkW=
SUNE-1 MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWGxNEDPxE1? Ml7EPVYhcA>? NETJT3lFVVOR Mk\6TWM2OD1yLkWyJO69VQ>? M2jTPVI2OzN4OUK1
CNE-2 M3rVT2Z2dmO2aX;uJGF{e2G7 M3jFdlExKM7:TR?= MmXrOFghcA>? NVPuVHJDTE2VTx?= MWTJcoR2[2W|IHPlcIwh[3mlbHWgZZJz\XO2IHH0JGcy MWqyOVM{Pjl{NR?=
HONE-1 M2HlN2Z2dmO2aX;uJGF{e2G7 MmXZNVAh|ryP M2XndlQ5KGh? M{jpc2ROW09? NULwdYdnUW6mdXPld{Bk\WyuIHP5Z4xmKGG{cnXzeEBifCCJMR?= M1\i[FI2OzN4OUK1
NEC8 MmS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHHeGs{UUN3ME2wMlA6PjVzIN88US=> NVvF[HhlW0GQR1XS
P12-ICHIKAWA MlfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjvNJdKSzVyPUCuNVE3OiEQvF2= NHLCW5ZUSU6JRWK=
MDA-MB-175-VII NFfBfnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;hVoMzUUN3ME2wMlE{PzN6IN88US=> MWXTRW5ITVJ?
AsPC-1 M3[3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFyzVGpKSzVyPUCuNlIyOjJizszN NGXvPVdUSU6JRWK=
T47D NXe0eHVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XyN2lEPTB;MD6yPFI2KM7:TR?= MXTTRW5ITVJ?
HH NG\NZppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NICxbXJKSzVyPUCuN|AzQDNizszN NVPycZdZW0GQR1XS
MOLT-16 Mm\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rBUWlEPTB;MD6zNFMzKM7:TR?= NIezb4lUSU6JRWK=
ES5 NXrLXphnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofkTWM2OD1yLkO0OFU2KM7:TR?= MWrTRW5ITVJ?
RS4-11 MonBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnPcmQ3UUN3ME2wMlM1PjFizszN MYrTRW5ITVJ?
KARPAS-45 NXnR[JNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwM{ezNlEh|ryP MmexV2FPT0WU
NCI-H720 M4TyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7wTWM2OD1yLkO3Olc6KM7:TR?= MnnTV2FPT0WU
H9 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXzSJRCUUN3ME2wMlM5QDh|IN88US=> NX\qc|doW0GQR1XS
EFM-19 MnrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvGNWNNUUN3ME2wMlQ1ODFizszN MUjTRW5ITVJ?
SBC-1 NFfwem1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvncXdtUUN3ME2wMlQ1ODN3IN88US=> MoHnV2FPT0WU
A4-Fuk Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnYOWpQUUN3ME2wMlQ3QDZ6IN88US=> M4rL[XNCVkeHUh?=
NCI-H1563 NX3rUJM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnJN|FKSzVyPUCuOFgyQDlizszN M{L2WnNCVkeHUh?=
HCC1419 M3TzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\kXpJKSzVyPUCuOFg5QTJizszN NU\TZ4s6W0GQR1XS
H-EMC-SS MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwNEm5N|kh|ryP M2rmO3NCVkeHUh?=
BHT-101 NEfOZ4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXnWo9EUUN3ME2wMlUzQTZzIN88US=> Ml\yV2FPT0WU
IGROV-1 MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTBwNUWyOFkh|ryP NIqwOpdUSU6JRWK=
HGC-27 NILXUINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HFV2lEPTB;MD61Olc5OyEQvF2= MojiV2FPT0WU
MDA-MB-361 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwNUe3OlEh|ryP NGLlSllUSU6JRWK=
KE-37 NFW3bGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXvVFdtUUN3ME2wMlU5OjZizszN MV7TRW5ITVJ?
HCC70 Mn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwNUm4Nlch|ryP NFnXXIpUSU6JRWK=
LNCaP-Clone-FGC M3;t[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLSc29KSzVyPUCuOlExPDhizszN MlHPV2FPT0WU
HAL-01 M2PaVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfVV5FuUUN3ME2wMlYzOTNizszN NF3rPZNUSU6JRWK=
HT NE\Lc4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjLTWM2OD1yLk[zNlM6KM7:TR?= NVyyeYxtW0GQR1XS
MDA-MB-415 MnjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfXOplKSzVyPUCuOlM3OjZizszN MUDTRW5ITVJ?
NOS-1 NVLDR21nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPXSXFKSzVyPUCuOlM4OjNizszN M1Pq[HNCVkeHUh?=
DU-145 MnjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDUWHJvUUN3ME2wMlY1PzR3IN88US=> NEC1bXdUSU6JRWK=
OCUB-M MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn5TWM2OD1yLkewPVY3KM7:TR?= M33kT3NCVkeHUh?=
VA-ES-BJ NV:wV5cxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILGTJlKSzVyPUCuO|MxOjVizszN MXHTRW5ITVJ?
J-RT3-T3-5 MmPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwN{S0NFMh|ryP MYnTRW5ITVJ?
MOLT-4 NIXwT3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnGTWM2OD1yLkiwOVgzKM7:TR?= MnXlV2FPT0WU
NB7 M3njdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHK0S|ZKSzVyPUCuPFI1OTFizszN NUj5RW5OW0GQR1XS
L-363 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYr3T3hoUUN3ME2wMlg{PDR{IN88US=> NX\Fd|A1W0GQR1XS
NKM-1 NXnWWGdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfabIZKSzVyPUCuPFYzPTNizszN MlnZV2FPT0WU
HOP-92 NFr1[5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zJfmlEPTB;MD64O|IzOyEQvF2= NUPr[HVkW0GQR1XS
OAW-42 NFOyNGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTCTWM2OD1yLki4O|Ih|ryP NVPjbVB{W0GQR1XS
HuO9 M3\pZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLvZnVVUUN3ME2wMlkzPzVzIN88US=> M2rzZXNCVkeHUh?=
MFE-280 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPpTWM2OD1yLkm2OFY2KM7:TR?= Mn[0V2FPT0WU
EM-2 NIfUSGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHWTWM2OD1yLkm3PVM6KM7:TR?= M13JU3NCVkeHUh?=
NCI-H520 NH3sTIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTBwOUi1PVIh|ryP NGTUNpJUSU6JRWK=
LB2241-RCC NWryTlZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljNTWM2OD1yLkm5O|M1KM7:TR?= MYXTRW5ITVJ?
SK-NEP-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDaSWp7UUN3ME2xMlE1PDh3IN88US=> NVL3UlB1W0GQR1XS
LXF-289 NGixV5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTFwMUexOVYh|ryP MUPTRW5ITVJ?
EPLC-272H MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfRNIJ[UUN3ME2xMlE4OjV4IN88US=> MX7TRW5ITVJ?
COLO-684 NIjWVIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTFwMkO3NlUh|ryP MlzHV2FPT0WU
ES1 NEPXeIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHLTWM2OD1zLkK0NFY2KM7:TR?= NVW3NGNvW0GQR1XS
DOHH-2 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDvTWM2OD1zLkK4NlA{KM7:TR?= NWfoOppZW0GQR1XS
CTB-1 NVH0dlFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTFwMki5PUDPxE1? M1O0SHNCVkeHUh?=
G-401 M3fmOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\DcWlEPTB;MT6yPVc6PSEQvF2= Mof3V2FPT0WU
LoVo MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X3emlEPTB;MT6zNlU{PCEQvF2= NEnhVZJUSU6JRWK=
Ramos-2G6-4C10 NXjNcJhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\NS2lEPTB;MT6zN|cxOSEQvF2= M1\2eXNCVkeHUh?=
MFM-223 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPHV|VKSzVyPUGuN|Q1PjFizszN MUDTRW5ITVJ?
PA-1 NUPFbFc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDFZXBsUUN3ME2xMlM2OjZ3IN88US=> NUTvfYdoW0GQR1XS
697 NIHhTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjRUZlXUUN3ME2xMlM4PjF4IN88US=> MW\TRW5ITVJ?
QIMR-WIL NXjRb5duT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;pTWM2OD1zLkS5NVE3KM7:TR?= MoH6V2FPT0WU
HOS MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTFwNEm1OVgh|ryP MnvHV2FPT0WU
DMS-273 NFrUZWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzJNoFSUUN3ME2xMlUyQTV7IN88US=> MnfsV2FPT0WU
ME-180 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITzXYNKSzVyPUGuOVY5QTFizszN NFP4VXNUSU6JRWK=
HCC2218 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHwWGJFUUN3ME2xMlY5OjJ3IN88US=> MnfuV2FPT0WU
CAL-54 NGDRTVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;YNWlEPTB;MT63NVI1OiEQvF2= MUDTRW5ITVJ?
OMC-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTFwN{S2O|ch|ryP NFvnVlJUSU6JRWK=
COR-L105 NV\ySGNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnzflE{UUN3ME2xMlc6PzN5IN88US=> NF[3[|dUSU6JRWK=
BV-173 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\KTWM2OD1zLkixNFc1KM7:TR?= NVHrW4tzW0GQR1XS
RKO MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTFwOEexNFEh|ryP MonoV2FPT0WU
SNU-387 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLwRVhKSzVyPUGuPFg1ODZizszN Mn\FV2FPT0WU
SW1088 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7KTWM2OD1zLkm0OlA3KM7:TR?= NEPj[4hUSU6JRWK=
Hs-578-T NGL5fYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3CcmVKSzVyPUKuNVE1OzNizszN MoHIV2FPT0WU
OC-314 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVm4UmZ2UUN3ME2yMlE2ODh4IN88US=> M2DMSnNCVkeHUh?=
RMG-I NUnLPHk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XXU2lEPTB;Mj6xOlM6QCEQvF2= M1nVTnNCVkeHUh?=
NCI-H1395 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTJwMUiwPVEh|ryP NXG2VmdXW0GQR1XS
GAMG MmDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJwMkO4OFUh|ryP MXfTRW5ITVJ?
LB1047-RCC NV;5TGhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3m1e2lEPTB;Mj6yOFMyPyEQvF2= M4fQS3NCVkeHUh?=
MN-60 M{\uZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPiUItKSzVyPUKuNlk6OjNizszN MlvKV2FPT0WU
OAW-28 M2jqW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvuW4VKSzVyPUKuNlk6PTFizszN MWnTRW5ITVJ?
NCI-H2228 NGXwV4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfzPYM{UUN3ME2yMlMyPTV{IN88US=> MUTTRW5ITVJ?
ABC-1 M33KOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnNdo5KSzVyPUKuN|MzPTNizszN MnX4V2FPT0WU
LS-513 MmXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkm3TWM2OD1{LkOzOFg1KM7:TR?= MV3TRW5ITVJ?
KS-1 NW\XTIdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK0TWM2OD1{LkO4NVkyKM7:TR?= M2LscHNCVkeHUh?=
NB69 NFzOboJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L2cmlEPTB;Mj6zPFk5OyEQvF2= M1XJOHNCVkeHUh?=
VM-CUB-1 M{LvdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[5clJ[UUN3ME2yMlM6ODh|IN88US=> MVnTRW5ITVJ?
D-423MG M2XBNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XtZ2lEPTB;Mj60NVA1PCEQvF2= NEXwUoVUSU6JRWK=
EW-18 MnK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTJwNEG5N|kh|ryP NGr6ZZpUSU6JRWK=
YH-13 MkX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDnTWM2OD1{LkS2NVU{KM7:TR?= Mn3QV2FPT0WU
T-24 NGjtO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PwVmlEPTB;Mj60O|g5OSEQvF2= NHj4b2dUSU6JRWK=
ES8 NIHDO3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLqN4tKSzVyPUKuOFkzQDdizszN NVvZc5V7W0GQR1XS
ES3 NIfQNXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfR[2hKSzVyPUKuOFk4PTlizszN NEDC[lNUSU6JRWK=
RXF393 M1XJUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3BbJhNUUN3ME2yMlYxPDh5IN88US=> MojEV2FPT0WU
RPMI-8226 Mn\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTJwNkK5OVMh|ryP Ml;1V2FPT0WU
AGS MmG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmS3TWM2OD1{LkeyNVM4KM7:TR?= MmPJV2FPT0WU
HCC1395 MlTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTJwN{WxPFch|ryP M1vRXHNCVkeHUh?=
MV-4-11 MmrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXwclROUUN3ME2yMlc2OjZ4IN88US=> NGrFWI1USU6JRWK=
A204 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInLO2lKSzVyPUKuPFM5PzJizszN NILuR5FUSU6JRWK=
MCF7 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XsVWlEPTB;Mj64OlEyPyEQvF2= MYfTRW5ITVJ?
SNU-423 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfuTWM2OD1{Lki5NlQzKM7:TR?= M4\6W3NCVkeHUh?=
NCI-H1048 M2CydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzQNo5KSzVyPUKuPVY5PjVizszN NYXOPI46W0GQR1XS
GR-ST NHfnTGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnVeGlKSzVyPUOuNFQ3OTFizszN MWfTRW5ITVJ?
EoL-1- MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHL3TlBKSzVyPUOuNFcxPThizszN M4rodXNCVkeHUh?=
HuH-7 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33Yb2lEPTB;Mz6wPVQ3PCEQvF2= NGntVItUSU6JRWK=
OS-RC-2 NH7kV2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTNwMUGxPUDPxE1? M1PPNXNCVkeHUh?=
EW-3 MnPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnGTWM2OD1|LkG5OVI6KM7:TR?= M4PqOXNCVkeHUh?=
NCI-H747 MmHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTkVlRzUUN3ME2zMlIxPjl2IN88US=> M1ToXnNCVkeHUh?=
EW-16 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTNwMkG4O|kh|ryP M4Ph[nNCVkeHUh?=
DOK MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTNwMkK4OVkh|ryP MnzVV2FPT0WU
HCC2157 M13uWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3[1fmlEPTB;Mz6zPFE4QSEQvF2= NHPxS4RUSU6JRWK=
OVCAR-3 NVTSV4VIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLJc5lSUUN3ME2zMlQxPzh4IN88US=> NF\SVYtUSU6JRWK=
NCI-H1623 NEC1[XpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTNwNEGyNlQh|ryP MW\TRW5ITVJ?
H4 NVzsU49jT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzBfnEzUUN3ME2zMlQ2PjJ4IN88US=> MYfTRW5ITVJ?
SW1710 NXzZbo1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfoZZk1UUN3ME2zMlQ3Pjd6IN88US=> NX3PZ2VLW0GQR1XS
RT-112 NGCxdphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG4TWM2OD1|LkWyN|g5KM7:TR?= MXjTRW5ITVJ?
DMS-114 MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTNwNkKyO|gh|ryP NYfHVmh4W0GQR1XS
AN3-CA MmfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NECzXmhKSzVyPUOuOlI1PTZizszN MWXTRW5ITVJ?
KNS-62 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PYN2lEPTB;Mz62N|M{QCEQvF2= NFrGNGtUSU6JRWK=
SJRH30 Mor1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XtVGlEPTB;Mz62PVEzOiEQvF2= MoDzV2FPT0WU
G-402 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvJTWM2OD1|LkewO|EyKM7:TR?= M2HuOHNCVkeHUh?=
MHH-PREB-1 M3rQXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTWNnFlUUN3ME2zMlczODN6IN88US=> M1HtSXNCVkeHUh?=
P30-OHK M2fPNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlS3TWM2OD1|LkiwPVc3KM7:TR?= NGTYU|dUSU6JRWK=
RVH-421 MofOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvscXVKSzVyPUOuPFE4QDhizszN MmTiV2FPT0WU
LU-134-A M12wV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfoU4ZKSzVyPUOuPFg1OjhizszN NVzpW3pHW0GQR1XS
ECC10 M2TjOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XVfGlEPTB;Mz65N|YzOiEQvF2= M3vacHNCVkeHUh?=
TGW M{nuUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fZemlEPTB;ND6wNlMxPSEQvF2= MoT0V2FPT0WU
MLMA M3vCRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{iwZWlEPTB;ND6wNlk3PiEQvF2= M4XobXNCVkeHUh?=
SCC-25 Ml25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTRwME[1OlYh|ryP NUPKNnBsW0GQR1XS
TYK-nu NXjmV2pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfNXoNqUUN3ME20MlA6PTN2IN88US=> NXW0enJlW0GQR1XS
LAMA-84 MnvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jpb2lEPTB;ND6xOFE6OSEQvF2= NVrpS5FvW0GQR1XS
Calu-3 NFLCd4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITicGlKSzVyPUSuNlQ1OTZizszN MUTTRW5ITVJ?
NCI-H460 NWToUHJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\4RWlEPTB;ND6yOlQ1OyEQvF2= NY\1[nlbW0GQR1XS
EGI-1 M{nkWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTRwM{e3O|gh|ryP M{f4dHNCVkeHUh?=
NCI-H292 MnjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHFO2NKSzVyPUSuN|gyPDZizszN NX32VlR7W0GQR1XS
HCE-T MmDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4j0Z2lEPTB;ND60NVU4QSEQvF2= MX;TRW5ITVJ?
EW-11 NH3FbldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4fTNWlEPTB;ND60NVg{QCEQvF2= NXfGb3NoW0GQR1XS
ATN-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTRwNESzNFQh|ryP NEfLUGhUSU6JRWK=
NB5 NVHkR4RNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\FTWM2OD12LkWzOlk4KM7:TR?= MWDTRW5ITVJ?
KLE M1;WRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XU[mlEPTB;ND63NFE6QCEQvF2= NX;NWIRtW0GQR1XS
CAL-39 NEXMVZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HkZ2lEPTB;ND63NlE1PiEQvF2= MUjTRW5ITVJ?
TI-73 NUDrc2p1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLITWM2OD12LkiwOlA6KM7:TR?= MnTNV2FPT0WU
HO-1-N-1 M2PhXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjNTWM2OD12Lkm0NkDPxE1? NIjYW3FUSU6JRWK=
786-0 NXnwZ4RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTRwOUS2O|Mh|ryP NIP6NWJUSU6JRWK=
SK-N-DZ M{LCRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnm4TWM2OD12Lkm2NVQzKM7:TR?= M1HhSnNCVkeHUh?=
NCI-H446 NIm2bplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzHTWM2OD13LkKwNFA6KM7:TR?= NYWxSGJMW0GQR1XS
ETK-1 NVj6N|VxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXYTWM2OD13LkKxNVY2KM7:TR?= NITkNWtUSU6JRWK=
BT-20 NFK1W2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXHZnBOUUN3ME21MlIyOzV|IN88US=> MYnTRW5ITVJ?
MEL-HO MkH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTVwM{ezN|Yh|ryP MlXIV2FPT0WU
CAL-27 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XTUGlEPTB;NT60OlM{QSEQvF2= MofUV2FPT0WU
SW872 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLwTWM2OD13LkW5OFI5KM7:TR?= NFTDe21USU6JRWK=
RPMI-2650 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDRTWJoUUN3ME21MlY3OTl7IN88US=> M4XxOXNCVkeHUh?=
PFSK-1 NUH6VZRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjETWM2OD13LkeyO|MzKM7:TR?= Ml;pV2FPT0WU
SF295 Mle2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTVwOEC2N|Mh|ryP MljxV2FPT0WU
Becker NIXoOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7BTWM2OD13Lki2OFczKM7:TR?= MXrTRW5ITVJ?
Saos-2 NV64VJhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTVwOE[1N{DPxE1? M1LFTXNCVkeHUh?=
SK-OV-3 M33QO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTsTWM2OD13Lkm5PFE3KM7:TR?= M2\jTXNCVkeHUh?=
VMRC-RCZ MlnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfDc3c6UUN3ME22MlA5Pzd|IN88US=> NVP1coxuW0GQR1XS
EW-22 NYjnclQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknUTWM2OD14LkG5OlQ6KM7:TR?= MmK1V2FPT0WU
BT-474 MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHBWJJ[UUN3ME22MlI{OyEQvF2= MoLRV2FPT0WU
BFTC-909 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HUW2lEPTB;Nj6zNFM1PSEQvF2= NYPybVBmW0GQR1XS
NB12 NUHXOFF[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmezTWM2OD14LkO5NFcyKM7:TR?= MVXTRW5ITVJ?
D-263MG NGe3[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzJc5dKSzVyPU[uOFUyPjlizszN M1;CcXNCVkeHUh?=
SNB75 NXfQTGczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTZwNkCxOFMh|ryP MlzEV2FPT0WU
A704 M1zqbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M160eWlEPTB;Nj62N|A3KM7:TR?= MVHTRW5ITVJ?
NCI-H1693 M1Xvcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\WflBKSzVyPU[uOlM3ODRizszN NF;RO3pUSU6JRWK=
LN-405 MkXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7GOmNCUUN3ME22Mlc6Pjd{IN88US=> NVPwUYhmW0GQR1XS
CHL-1 M{naXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXUfolKSzVyPU[uPFAxPzlizszN NH3mcHhUSU6JRWK=
A498 MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL3TWM2OD14LkixPVYyKM7:TR?= NH;CR3hUSU6JRWK=
TE-12 NFTwTotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\5bWxKSzVyPU[uPFM5OTdizszN NGrhV4FUSU6JRWK=
TE-6 Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3rTWM2OD14LkmzNFM5KM7:TR?= MVjTRW5ITVJ?
AU565 M3m1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLOTWM2OD14Lkm2PVU4KM7:TR?= MV7TRW5ITVJ?
RD M{TRTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7sTWM2OD14Lkm4Nlg1KM7:TR?= MnXYV2FPT0WU
SW1463 NXi2dXRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnYTWM2OD15LkGxNVY5KM7:TR?= MXXTRW5ITVJ?
LU-99A MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTdwMUSzNlIh|ryP M1rCdnNCVkeHUh?=
NCI-H28 NG[wfYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvNbXY4UUN3ME23MlI6OjRizszN MnTZV2FPT0WU
MC-IXC MmjhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnCOm92UUN3ME23MlQ5PTd4IN88US=> NFzL[IJUSU6JRWK=
GP5d Mm\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17rN2lEPTB;Nz60PFc3PCEQvF2= MnvVV2FPT0WU
GB-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTdwNUS4NFQh|ryP M2XBVXNCVkeHUh?=
CAL-33 Mm\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTdwNk[yN|Mh|ryP NYjhcWY2W0GQR1XS
MSTO-211H MmL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXBbXBKSzVyPUeuOlc{OzZizszN NF6yRXhUSU6JRWK=
TE-5 M{nqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2SxUWlEPTB;Nz63PVM{PCEQvF2= MYDTRW5ITVJ?
D-566MG Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vhfGlEPTB;OD6wOFQzQSEQvF2= NETWSYpUSU6JRWK=
JVM-3 M3Ll[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;LdWlEPTB;OD6xOVI3QCEQvF2= M13s[HNCVkeHUh?=
T98G NYS1fHhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfHTmhKSzVyPUiuNVgxPjdizszN NIPEOJFUSU6JRWK=
HCC1954 MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRThwNEWxNFQh|ryP M{jiT3NCVkeHUh?=
SF126 NUXGdGlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRThwNEW5N|Yh|ryP MlLxV2FPT0WU
LB996-RCC M1TJOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXyTWM2OD16LkWzNlU4KM7:TR?= NGPHPZVUSU6JRWK=
SKG-IIIa MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVu1Z3A5UUN3ME24MlY{ODZ7IN88US=> M4HrTXNCVkeHUh?=
NCI-SNU-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{X6NGlEPTB;OD62OFY1OyEQvF2= M2X0OHNCVkeHUh?=
LB771-HNC M3v5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{f2VWlEPTB;OD62OFY6PiEQvF2= NUnDW3ZrW0GQR1XS
SCC-4 M4rTbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjyTlNMUUN3ME24MlY5OjF7IN88US=> M{Hke3NCVkeHUh?=
CAMA-1 NGTpUpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXuXIJuUUN3ME24Mlc4OTR4IN88US=> MYXTRW5ITVJ?
D-502MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfP[FdHUUN3ME24Mlc5PjJ7IN88US=> NEi0VXBUSU6JRWK=
ESS-1 M17wZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDQeHVsUUN3ME24Mlg5PzB2IN88US=> NH7QXJNUSU6JRWK=
HEC-1 M1\ZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\WVFRKSzVyPUiuPFk5PjZizszN NV73UpJHW0GQR1XS
NB10 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvITWM2OD17LkCyNlI1KM7:TR?= NXTte4VzW0GQR1XS
8505C MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfScHdKSzVyPUmuNFQzOzJizszN NUH4ZYpmW0GQR1XS
EFO-27 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG[xSGxKSzVyPUmuNVY1OTJizszN MVfTRW5ITVJ?
HN MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zqb2lEPTB;OT6xOlYzQCEQvF2= MmXqV2FPT0WU
DSH1 MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLvTWM2OD17LkKwPFch|ryP NUPUfHBXW0GQR1XS
NBsusSR M1PkWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\WbYV2UUN3ME25MlI4PDB{IN88US=> NXvPe4UxW0GQR1XS
LS-123 NIjJRlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTlwM{G3OlEh|ryP NFTVOHNUSU6JRWK=
SHP-77 MkPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PtW2lEPTB;OT6zPVk{PSEQvF2= NEW5RZFUSU6JRWK=
ACN MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGyTWM2OD17LkWzNlc4KM7:TR?= NXnsdZpRW0GQR1XS
U251 NFnmS5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTlwNkW1OFQh|ryP NYHNZ5dXW0GQR1XS
A431 NIrRfHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX2PYJKSzVyPUmuPFAzOzhizszN NUPEcmJsW0GQR1XS
5637 NWrOeYJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n4N2lEPTB;OT64OFk5PCEQvF2= NXPnXI9ZW0GQR1XS
MDA-MB-157 NVTsUZJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTlwOUK4O|gh|ryP NUD1Z2ZyW0GQR1XS
A101D MnnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF20SldKSzVyPUmuPVk6PzRizszN M4DaXnNCVkeHUh?=
YKG-1 M3WwSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjoOll3UUN3ME2xNE4zODB4IN88US=> NUnyXZk{W0GQR1XS
LAN-6 NF3FdnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\ZR4xKSzVyPUGwMlIyPjRizszN NWTse3BYW0GQR1XS
OVCAR-5 Mn3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITSU3hKSzVyPUGwMlI1OzNizszN NF;rPVBUSU6JRWK=
A549 M3vHUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[0dIVGUUN3ME2xNE4{QTd|IN88US=> NVTmdXI5W0GQR1XS
no-11 Mn:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTFyLkSzOVMh|ryP MWjTRW5ITVJ?
SF539 NETBd|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX5TWM2OD1zMD65NFQyKM7:TR?= MUHTRW5ITVJ?
A388 NETxVFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PHRmlEPTB;MUGuN|g6PyEQvF2= MWPTRW5ITVJ?
DEL MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jVbWlEPTB;MUGuOFI1KM7:TR?= Ml7vV2FPT0WU
SW954 NUPYW21XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rUe2lEPTB;MUGuOFY3QCEQvF2= M4rsOHNCVkeHUh?=
TK10 NUTqeHhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrm[mVGUUN3ME2xNU42OjdzIN88US=> MXvTRW5ITVJ?
SW756 MmqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXO2Umg5UUN3ME2xNU42Ojl2IN88US=> MkHuV2FPT0WU
PC-3 NFTUXXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvzeHY4UUN3ME2xNU42PzZ2IN88US=> NXrNcGpLW0GQR1XS
ONS-76 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn4TWM2OD1zMT62N|Yh|ryP NVSyUnM4W0GQR1XS
A427 NY\Ve2U2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLrTWM2OD1zMT63NFk{KM7:TR?= M1PL[nNCVkeHUh?=
MEG-01 NWLa[XNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTFzLke1NFkh|ryP MXfTRW5ITVJ?
BB30-HNC M3q4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nu[WlEPTB;MUGuO|k5OiEQvF2= MWLTRW5ITVJ?
NCI-H1299 MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2P6RmlEPTB;MUGuPFA6OyEQvF2= NXnSRZZ[W0GQR1XS
GCT NXLnTXJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[3Z2lEPTB;MUGuPFIzQCEQvF2= NXf2UGpHW0GQR1XS
D-247MG NECy[pJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHic4pKSzVyPUGxMlk3PjNizszN MWDTRW5ITVJ?
CFPAC-1 NFLrNHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\JPJc5UUN3ME2xNU46Pzh{IN88US=> MofIV2FPT0WU
EKVX NIO4c5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWe4NZRlUUN3ME2xNk4xOzF|IN88US=> NHPINGlUSU6JRWK=
CAL-51 NEnseotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTF{LkC3NVYh|ryP NHPPWY1USU6JRWK=
BB49-HNC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTF{LkGxO|ch|ryP M3XkUHNCVkeHUh?=
RPMI-7951 M4\OPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF{LkG4OVQh|ryP M2PIeHNCVkeHUh?=
RH-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf4SlBKSzVyPUGyMlIyQDRizszN Ml75V2FPT0WU
BCPAP M3TEeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWC4ZXVIUUN3ME2xNk41PzR7IN88US=> M2rFSXNCVkeHUh?=
GCIY NVHne|N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTyWWZ5UUN3ME2xNk42OjB7IN88US=> MY\TRW5ITVJ?
KNS-81-FD NF\aO4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1n3OmlEPTB;MUKuOVg3QSEQvF2= MXXTRW5ITVJ?
KYSE-140 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2iyfGlEPTB;MUKuPFU6PSEQvF2= Mly2V2FPT0WU
Ca-Ski NUXuNJptT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXJd|BKSzVyPUGyMlkxPDFizszN MUHTRW5ITVJ?
TGBC1TKB NWLHcYNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGG0T5ZKSzVyPUGyMlkyOTVizszN M4Syc3NCVkeHUh?=
HCC1187 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTF|LkG5NVIh|ryP NUHI[nd3W0GQR1XS
SJSA-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{T3UWlEPTB;MUOuNlMzPyEQvF2= NH30PYdUSU6JRWK=
CTV-1 MonjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTOTWM2OD1zMz6zOFUh|ryP M2TpVnNCVkeHUh?=
WM-115 M{C2c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTF|Lk[0PFMh|ryP MkDvV2FPT0WU
CHP-212 MnXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1GzbmlEPTB;MUOuPVc{QSEQvF2= MlLiV2FPT0WU
SCC-15 MljyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PXVWlEPTB;MUOuPVc4PSEQvF2= NEm4XldUSU6JRWK=
BPH-1 NHnYV3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jOcGlEPTB;MUSuNVY3PCEQvF2= MW\TRW5ITVJ?
SW780 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rOTWlEPTB;MUSuOVAzPSEQvF2= MXXTRW5ITVJ?
NCI-H2291 NULGVGpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTrO41KSzVyPUG0MlU5PzhizszN Ml;jV2FPT0WU
JEG-3 M4T2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7wTWM2OD1zND62N|I3KM7:TR?= NV6z[3c3W0GQR1XS
CAL-120 NGezdXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjhTWM2OD1zND63NFI4KM7:TR?= NWnRW5oxW0GQR1XS
NCI-H23 NEXPUIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\UWoVFUUN3ME2xOE44QTl5IN88US=> MV;TRW5ITVJ?
MS-1 NGm4OZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPjUGJKSzVyPUG0Mlk3OTFizszN NYD3eXQ6W0GQR1XS
PC-14 MkjxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnzNmZoUUN3ME2xOE46PjV2IN88US=> NWLpTWVMW0GQR1XS
D-283MED MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF3LkCxNVEh|ryP NHnOUoxUSU6JRWK=
OE19 Mkj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3j6bmlEPTB;MUWuNVU1OSEQvF2= MmPJV2FPT0WU
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CCRF-CEM NGDqV4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTJ2Mz63PVUh|ryP NI[xd3NUSU6JRWK=
SH-4 MmLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnETWM2OD1{NE[uNFkh|ryP MWLTRW5ITVJ?
LS-1034 MmPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PLc2lEPTB;MkS2MlI3PiEQvF2= M3LzTXNCVkeHUh?=
NCI-H2347 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jxOWlEPTB;MkS3MlcyOyEQvF2= MkHZV2FPT0WU
RPMI-8866 MnTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nLSWlEPTB;MkS5MlI4KM7:TR?= MUXTRW5ITVJ?
GAK MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DyPGlEPTB;MkWzMlAxOiEQvF2= NYLjcFV1W0GQR1XS
NB6 M2HFSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfqTWM2OD1{N{CuNUDPxE1? MUDTRW5ITVJ?
COLO-680N NGixPGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTJ5Mj61Nlch|ryP NIjmR5RUSU6JRWK=
RERF-LC-MS NVu0XYc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f5R2lEPTB;Mke2MlAxPyEQvF2= NXLoPYczW0GQR1XS
TGBC11TKB Ml\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj1VY1KSzVyPUK3PE4yPzhizszN M3GyeXNCVkeHUh?=
C8166 MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2q0PWlEPTB;Mke4MlUxPiEQvF2= MmixV2FPT0WU
HDLM-2 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TGXWlEPTB;Mkm0MlQxQSEQvF2= MV\TRW5ITVJ?
IGR-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTJ7NT62OVkh|ryP NITKVlJUSU6JRWK=
FADU Mo\wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{T4ZmlEPTB;Mkm3MlUyKM7:TR?= M{CwOnNCVkeHUh?=
L-428 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnOTWM2OD1{OUeuOlE3KM7:TR?= MojKV2FPT0WU
LU-65 MkDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Ha[2lEPTB;M{C0MlMzKM7:TR?= NFO2b3pUSU6JRWK=
HEL MkDlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTNyOT65PFMh|ryP NWW3e3VKW0GQR1XS
NCI-H810 NH;yfHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1SyN2lEPTB;M{GwMlU4KM7:TR?= NVvaPXJwW0GQR1XS
C3A MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTNzMT64NFIh|ryP M1HVNHNCVkeHUh?=
NCI-H630 NFXOU2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\B[WZKSzVyPUOzNk4zQTRizszN NUe1fIRmW0GQR1XS
KP-N-YN MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUixcYprUUN3ME2zOFEvOTJ|IN88US=> MX\TRW5ITVJ?
MOLT-13 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPv[ZJKSzVyPUO0Nk4{OjZizszN Mnq3V2FPT0WU
NCI-H1993 MnHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\LTWM2OD1|NEKuN|Y2KM7:TR?= MXzTRW5ITVJ?
BE-13 MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzYTYpyUUN3ME2zOFQvOTZ5IN88US=> NEXHXJBUSU6JRWK=
IST-SL1 M3rkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnMfJlKSzVyPUO0O{41ODFizszN M{TuTHNCVkeHUh?=
TE-9 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKxTWM2OD1|NkOuOVg6KM7:TR?= M3fjZnNCVkeHUh?=
LU-135 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLzdItGUUN3ME2zOlcvODN3IN88US=> M{Sx[nNCVkeHUh?=
T84 NFTJfmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP1S4tKSzVyPUO3OE44OTJizszN MmPvV2FPT0WU
K-562 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjPTWM2OD1|OEOuN|Yh|ryP NFWweJZUSU6JRWK=
SBC-5 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTN6Nj65PFUh|ryP NWrCdJFPW0GQR1XS
NB17 NX;TdIlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfidIpKSzVyPUO5Nk42QTZizszN NVjFcVNSW0GQR1XS
NCI-H2052 NWPPPWFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17wWGlEPTB;M{m4MlQ4OiEQvF2= MWTTRW5ITVJ?
HCC38 NVzUSHhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzWVHRKSzVyPUSwNU42QTNizszN NYiyNVhrW0GQR1XS
NCI-H69 MojES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHadYVoUUN3ME20OFEvODh|IN88US=> NGS5fWhUSU6JRWK=

... Click to View More Cell Line Experimental Data

体内研究 MK-2206和这些细胞毒素药剂联用作用于NCI-H292移植瘤,MK-2206显示出非常有效的抗癌活性。卵巢癌A2780移植瘤中,按动物体重,每千克处理240mg MK-2206,则可抑制70%以上的Akt1/2在苏氨酸308位点和丝氨酸473位点的磷酸化,导致肿瘤生长抑制率达到60%。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:[3]
+ 展开

Akt激酶实验:

通过得到的GSK 生物素肽段基质测定Akt激酶。使用含镧系金属螯合物偶联单抗的均相时间分辨荧光(HTRF)测定肽段磷酸化程度,这种单抗专门作用于与链霉亲和素——藻蓝素(SA-APC)载体相结合的磷酸化作用,SA-APC载体可以结合到肽段的部分生物素上。当镧系金属螯合物与藻蓝素相接触时,无辐射的能量从镧系金属螯合物传递给藻蓝素,然后藻蓝素发射波值为655纳米的光线。工作液:100X 蛋白酶抑制剂混合物(PIC):1mg/ml苯甲脒,0.5 mg/ml 抑肽素, 0.5 mg/ml亮抑肽酶, 0.5 mg/ml 抑肽酶。10X实验 buffer: 500 mM HEPES(pH 为7.5), 1% PEG, 16.6 mM EDTA, 1 mM EGTA, 1% BSA, 20 mM 9-甘油磷酸。抑制 buffer:50 mM HEPES(pH为7.3), 16.6 mM EDTA, 0.1% BSA, 0.1% Triton X-100, 0.17 nM 标记的单抗, 0.0067mg/ml SA-APC。ATP/MgCl2工作液: 1X 实验buffer, 1 mM DTT, 1X PIC, 5% 甘油, 激活的Akt。肽段工作液:1X实验buffer, 1 mM DTT, 1X PIC, 5% 甘油 2 TM GSK生物素肽段。工作液加到合适的孔中,然后加入总负荷为16的 ATP/MgCl2,反应开始。含MK-2206的实验组和对照组加入总负荷为10的肽段工作液。然后加入总负荷为13的酶液,混匀。反应进行50分钟,然后加入总负荷为60的均相时间分辨荧光抑制buffer停止反应。阻断的反应在室温下温育30分钟以上,然后使用仪器读数。
细胞实验:[2]
+ 展开
  • Cell lines: A431, HCC827, NCI-H292, NCI-H358, NCI-H23, NCI-H1299, Calu-6,和NCI-H460细胞
  • Concentrations: 0, 0.3, 1,和3 μM
  • Incubation Time: 72或96小时
  • Method: MK-2206溶解在DMSO中,在实验使用前用培养基稀释。细胞按2~3×103密度接种在96孔板上,温育24小时。MK-2206 (分为0, 0.3, 1,和3 μmol四组)处理细胞,72或者96小时后,测定细胞增殖情况。
    (Only for Reference)
动物实验:[2]
+ 展开
  • Animal Models: 携带SK-OV-3, NCI-H292, HCC70, PC-3,和NCI-H460模型的雄性CD1裸鼠
  • Formulation: 30% Captisol
  • Dosages: 120 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 14 mg/mL (29.14 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次加入纯溶剂:
15% Captisol
17 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 480.39
化学式

C25H21N5O.2HCl

CAS号 1032350-13-2
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01306045 Recruiting Carcinoma, Non-Small-Cell Lung|Carcinoma, Small Cell Lung|Carcinoma, Thymic National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) January 21, 2011 Phase 2
NCT01802320 Active, not recruiting Colon Mucinous Adenocarcinoma|Colon Signet Ring Cell Adenocarcinoma|Rectal Mucinous Adenocarcinoma|Rectal Signet Ring Cell Adenocarcinoma|Recurrent Colon Carcinoma|Recurrent Rectal Carcinoma|Stage IIIA Colon Cancer|Stage IIIA Rectal Cancer|Stage IIIB Colon Cancer|Stage IIIB Rectal Cancer|Stage IIIC Colon Cancer|Stage IIIC Rectal Cancer|Stage IVA Colon Cancer|Stage IVA Rectal Cancer|Stage IVB Colon Cancer|Stage IVB Rectal Cancer National Cancer Institute (NCI) March 2013 Phase 2
NCT01783171 Active, not recruiting Pancreatic Adenocarcinoma|Recurrent Pancreatic Carcinoma|Stage III Pancreatic Cancer|Stage IV Pancreatic Cancer|Unresectable Pancreatic Carcinoma National Cancer Institute (NCI) January 2013 Phase 1
NCT01776008 Active, not recruiting Estrogen Receptor Positive|HER2/Neu Negative|Recurrent Breast Carcinoma|Stage IIA Breast Cancer|Stage IIB Breast Cancer|Stage IIIA Breast Cancer|Stage IIIB Breast Cancer|Stage IIIC Breast Cancer National Cancer Institute (NCI) January 2013 Phase 2
NCT01859182 Withdrawn Adenocarcinoma of the Gallbladder|Adenocarcinoma With Squamous Metaplasia of the Gallbladder|Adult Primary Cholangiocellular Carcinoma|Advanced Adult Primary Liver Cancer|Cholangiocarcinoma of the Extrahepatic Bile Duct|Localized Unresectable Adult Primary Liver Cancer|Metastatic Extrahepatic Bile Duct Cancer|Recurrent Adult Primary Liver Cancer|Recurrent Extrahepatic Bile Duct Cancer|Stage II Gallbladder Cancer|Stage IIIA Gallbladder Cancer|Stage IIIB Gallbladder Cancer|Stage IVA Gallbladder Cancer|Stage IVB Gallbladder Cancer|Unresectable Extrahepatic Bile Duct Cancer National Cancer Institute (NCI) January 2013 Phase 2
NCT01705340 Terminated Adenocarcinoma of the Gastroesophageal Junction|HER2-positive Breast Cancer|Male Breast Cancer|Recurrent Breast Cancer|Recurrent Esophageal Cancer|Recurrent Gastric Cancer|Stage IIIC Breast Cancer|Stage IIIC Esophageal Cancer|Stage IIIC Gastric Cancer|Stage IV Breast Cancer|Stage IV Esophageal Cancer|Stage IV Gastric Cancer National Cancer Institute (NCI) September 2012 Phase 1

技术支持

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操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    What is your recommendation for preparing the solution and how would you deliver it to the mice (i.p. or gavage)?

  • 回答:

    You can resuspend MK-2206 in 15% Captisol at up to 17mg/ml. It's a suspension and is for oral gavage use only.

  • 问题 2:

    I would want to know if MK-2206 could cross the blood brain barrier?

  • 回答:

    MK-2206 can cross BBB based on the following reference: https://clinicaltrials.gov/ct2/show/NCT01249105.

Akt Signaling Pathway Map

Akt Inhibitors with Unique Features

相关Akt产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID