TRPM7 Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human Mouse Rat | ||
| MW (kDa) | 213kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | TRPM7 Rabbit Recombinant mAb detects endogenous levels of total TRPM7. |
|---|---|
| 背景 | The channel-kinase transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein with ion channel and kinase domains. TRPM7 is widely expressed in human cells and tissues, including the immune system, and is involved in a variety of cellular functions, including cell migration and homing, macrophage activation and polarization, and mast cell degranulation. This ubiquitously expressed ion channel is permeable to divalent cations including Ca2+, Mg2+, and Zn2+. At the cellular level, TRPM7 is implicated in cellular Mg2+ homeostasis, cell survival, proliferation, as well as cell adhesion and motility. At the physiological level, TRPM7 is linked to the regulation of vertebrate magnesium homeostasis primarily through its physical association with its homolog TRPM6. TRPM7 is essential for B cell development. |
实验方法
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