Recombinant Human TrkB Fc, CF(HEK293)

Human

hFc with His tag at the C-terminus.

71.7 kDa

120 kDa-130 kDa, reducing conditions

>95% as determined by Bis-Tris PAGE.

< 0.1 EU/ug by the LAL method

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

For long-term storage, keep the product lyophilized at -20°C or below. Please avoid repeated freeze-thaw cycles. Stability:​ Lyophilized: 12 months (-20°C to -80°C) Reconstituted: 3 months at -80°C under sterile conditions.

Q16620, NP_001018074.1

NTRK2; GP145-TrkB; TRKB; trk-B; BDNF/NT-3 growth factors receptor;GP145-TrkB;TRKB;trkB;TrkB;OBHD

TrkB受体，又称TrkB酪氨酸激酶或BDNF/NT-3生长因子受体或神经营养性酪氨酸激酶受体2型（NTRK2），是一种具有胞内酪氨酸激酶活性的单次跨膜催化受体。TrkB/NTRK2属于神经营养性酪氨酸受体激酶（NTRK）家族，包含两个Ig样C2型结构域、两个LRR（富含亮氨酸）重复序列、一个LRRCT结构域、一个LRRNT结构域及一个蛋白激酶结构域。TrkB/NTRK2酪氨酸激酶与Ras、Cdc42/Rac/RhoG、MAPK、PI3-K和PLCγ信号通路相偶联。TrkB/NTRK对脑源性神经营养因子（BDNF）具有高亲和力，参与神经元可塑性、长时程增强及中枢神经系统神经元的凋亡过程。作为膜结合受体，TrkB/NTRK与神经营养因子结合后发生自磷酸化，并磷酸化MAPK通路成员。NTRK2/TrkB通过调控神经元存活、增殖、迁移、分化及突触形成与可塑性，参与中枢与周围神经系统的发育和成熟。TrkB/NTRK的突变与肥胖及情绪障碍相关。