MALT

特异性亚型抑制剂

• MALT1 Selective

MALT产品

目录号	产品描述	文献引用	实验数据
S8898	MLT-748 MLT-748 是一种有效的、选择性的 MALT1 的变构抑制剂，IC50值为5 nM。MLT-748 通过置换 Trp580 而结合在半胱天冬酶和免疫球蛋白 (Ig3) 域之间的交界面上并将催化位点锁定在非活性的状态。
S7429	MI-2 (MALT1 inhibitor) MI-2 (MALT1 inhibitor) 是不可逆的MALT1抑制剂，其IC50为 5.84 μM。	Blood Adv, 2020, 4(5):819-829 Cell Metab, 2019, 29(5):1166-1181 Mol Carcinog, 2019, 58(12):2340-2352	(a-b) Cell growth analysis via MTT assay. Melanoma cell lines, including A2028, A375, WM35, Skmel28, CRL7625 and CRL7626, were seeded in 96-well dishes, and treated in tetrads for 48 hours with varying doses of MI-2. Graph represents average percent of live cells normalized to the untreated group +/- SD.
S9896New	JNJ-67856633 JNJ-67856633 (JNJ-6633) 是一种有效的、选择性的 MALT1 protease 变构抑制剂。

目录号	产品描述	文献引用	实验数据
S8898	MLT-748 MLT-748 是一种有效的、选择性的 MALT1 的变构抑制剂，IC50值为5 nM。MLT-748 通过置换 Trp580 而结合在半胱天冬酶和免疫球蛋白 (Ig3) 域之间的交界面上并将催化位点锁定在非活性的状态。
S7429	MI-2 (MALT1 inhibitor) MI-2 (MALT1 inhibitor) 是不可逆的MALT1抑制剂，其IC50为 5.84 μM。	Blood Adv,2020, 4(5):819-829 Cell Metab,2019, 29(5):1166-1181 Mol Carcinog,2019, 58(12):2340-2352	(a-b) Cell growth analysis via MTT assay. Melanoma cell lines, including A2028, A375, WM35, Skmel28, CRL7625 and CRL7626, were seeded in 96-well dishes, and treated in tetrads for 48 hours with varying doses of MI-2. Graph represents average percent of live cells normalized to the untreated group +/- SD.
S9896New	JNJ-67856633 JNJ-67856633 (JNJ-6633) 是一种有效的、选择性的 MALT1 protease 变构抑制剂。