Neurokinin Receptor
抑制剂选择性比较
Neurokinin Receptor产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1189 |
AprepitantAprepitant (MK-0869, L-754030)是一种有效的选择性 neurokinin-1 receptor 拮抗剂,IC50为0.1 nM。Aprepitant 可降低炎症因子的表达水平,包括 G-CSF、IL-6、IL-8 和 TNFα。Aprepitant 可抑制人巨噬细胞 HIV 的感染。 |
![]() ![]() HepT1, HepG2, and HuH6 cells were treated with increasing doses of aprepitant or SP [100 nM] and Western blot analysis was performed for the apoptotic markers PARP, Caspase-3, and BID. |
|
S3038 |
Fosaprepitant dimeglumine saltFosaprepitant dimeglumine salt (MK-0517)是一种水溶性的阿瑞匹坦(aprepitant)磷酰基前体药物,是一种NK1拮抗剂。 |
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S5476 |
RolapitantRolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit. |
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S0772New |
L-732138L-732138 (L-732,138) 是一种有效的、选择性的 neurokinin-1 (NK-1) receptor/substance P (SP) receptor 的竞争性拮抗剂。L-732138 可在CHO细胞中抑制125I-SP与稳定表达的人类NK-1受体的结合,其IC50值为2.3 nM。 |
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S4654 |
NetupitantNetupitant (CID6451149) 是一种选择性的神经激肽1(NK1)受体拮抗剂,具有潜在的止吐剂活性。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S1189 |
AprepitantAprepitant (MK-0869, L-754030)是一种有效的选择性 neurokinin-1 receptor 拮抗剂,IC50为0.1 nM。Aprepitant 可降低炎症因子的表达水平,包括 G-CSF、IL-6、IL-8 和 TNFα。Aprepitant 可抑制人巨噬细胞 HIV 的感染。 |
![]() ![]() HepT1, HepG2, and HuH6 cells were treated with increasing doses of aprepitant or SP [100 nM] and Western blot analysis was performed for the apoptotic markers PARP, Caspase-3, and BID. |
|
S3038 |
Fosaprepitant dimeglumine saltFosaprepitant dimeglumine salt (MK-0517)是一种水溶性的阿瑞匹坦(aprepitant)磷酰基前体药物,是一种NK1拮抗剂。 |
||
S5476 |
RolapitantRolapitant (SCH-619734) is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit. |
||
S0772New |
L-732138L-732138 (L-732,138) 是一种有效的、选择性的 neurokinin-1 (NK-1) receptor/substance P (SP) receptor 的竞争性拮抗剂。L-732138 可在CHO细胞中抑制125I-SP与稳定表达的人类NK-1受体的结合,其IC50值为2.3 nM。 |
||
S4654 |
NetupitantNetupitant (CID6451149) 是一种选择性的神经激肽1(NK1)受体拮抗剂,具有潜在的止吐剂活性。 |