Calcitriol (RO215535)

For research use only. Not for use in humans.

目录号:S1466 别名: Topitriol, 1,25-Dihydroxyvitamin D3 中文名称:骨化三醇

Calcitriol (RO215535) Chemical Structure

CAS No. 32222-06-3

Calcitriol (RO215535, Topitriol, 1,25-Dihydroxyvitamin D3)作为vitamin D的激素活性形式,是一种非选择性vitamin D receptor的激活剂,对vitamin D receptor的结合亲和力(IC50=0.4 nM)是选择性VDRA paricalcitol的10倍以上。建议现配现用。

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客户使用Selleck生产的Calcitriol (RO215535)发表文献37篇:

产品安全说明书

Vitamin抑制剂选择性比较

生物活性

产品描述 Calcitriol (RO215535, Topitriol, 1,25-Dihydroxyvitamin D3)作为vitamin D的激素活性形式,是一种非选择性vitamin D receptor的激活剂,对vitamin D receptor的结合亲和力(IC50=0.4 nM)是选择性VDRA paricalcitol的10倍以上。建议现配现用。
靶点
vitamin D receptor [1]
(Cell-free assay)
体外研究

Calcitriol是PHA诱导的淋巴细胞增殖的有效抑制剂,在培养72小时后抑制70%氚标记的胸腺嘧啶核苷掺入。Calcitriol以浓度依赖性方式抑制PHA刺激的外周血单核细胞中白细胞介素-2(IL-2)的生产。[1] Calcitriol通过从内质网和肌醇1,4,5-三磷酸肌醇和甘油二酯的形成动员钙,在5秒内增加细胞内钙离子浓度。[2] Calcitriol能抑制人前列腺腺癌细胞增殖,促进人前列腺腺癌细胞的分化。Calcitriol选择性降低IV型胶原酶(MMP-2和MMP-9)的分泌水平。[3] 在鳞状细胞癌和前列腺癌中,Calcitriol具有抗增殖活性,并增强基于铂的药物的抗肿瘤活性。在小鼠鳞状细胞癌和PC-3细胞中,Calcitriol比paclitaxel有更强的作用,降低降低克隆存活。 [4] Calcitriol是在多种恶性细胞类型的一种有效的抗增殖剂。Calcitriol通过一下方面发挥作用,增加G0/G1期阻滞,诱导细胞凋亡和分化,生长因子受体的表达的调节。Calcitriol促进许多细胞毒性剂的抗肿瘤作用和抑制能肿瘤细胞的侵袭性和形成新血管。[5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HCT116 MlGyR5l1d3SxeHnjxsBie3OjeR?= NUDxfW0{OTJyIHi= M2rpemN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGhEXDFzNjDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiClZXzsJINwfW62IHHmeIVzKDF{MDDodpMtKEmFNUC9NYUuODVizszN MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl{NkC2PEc,OjJ7Mk[wOlg9N2F-
HOS NYrYTlZsTnWwY4Tpc44h[XO|YYm= MXrBZ5Rqfmm2eTDheEBpfW2jbjDWSHIh\XiycnXzd4VlKGmwIHj1cYFvKEiRUzDj[YxteyC2cnHud4Zm[3SnZDD3bZRpKHCJTEOtbG9kNCCyQ1TORU1pXkSUIHHu[EBxcFKOLWTLJIF{e2W|c3XkJIF{KGG|c3Xzd4VlKGG|IITyZY5{[3KrcITpc45idCCjY4TpeoF1cW:wIH3lZZN2emWmIEK0JIhzeyCyb4P0JIlv\mWldHnvckBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTBiPTCwMlAxODBzIN88UU4> M2L3NVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOEi5N|M1Lz5{MUi4PVM{PDxxYU6=
SK-MEL-188 MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYDhToJiPDhiaILz NVS0U45wT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvTVXMMVE5QCClZXzsd{Bu\WG|dYLl[EBi\nSncjC0PEBpenNiYomgUXRUN1CPUzDhd5NigSxiSVO1NEA:KDBwMECwNFEh|ryPLh?= NEjrUmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3NFc4QSd-MkewO|A4Pzl:L3G+
osteosarcoma cells M1rVRWZ2dmO2aX;uJIF{e2G7 NWj0e5FDTW[oZXP0JI9vKF[GUjD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliaX6gbJVu[W5ib4P0[Y9{[XKlb33hJINmdGy|LDDFR|UxKD1iMD6wNFAxOTB4IN88UU4> Ml3rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOThyNUSyN|AoRjF6MEW0NlMxRC:jPh?=
HOS/SF MkmzSpVv[3Srb36gZZN{[Xl? MWmyOEBpenN? Mlv5WJJidnOjY4TpeoF1cW:wIH;mJHZFWi2vZXTpZZRm\CCxc4Tlc4NidGOrbjDwdo9ud3SncjDpckBpfW2jbjDIU3MwW0ZiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NEA:KDBwMECwNFI3KM7:TT6= NYPnRo9ORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA4OjhpPkK0PVAxPzJ6PD;hQi=>
LM05e MXTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MoK1O|IhcHK| NGHISFhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JI1wfXOnIFzNNFVmKGOnbHzzJIF{e2W|c3XkJIF{KGSnY4LlZZNmKGmwIHPlcIwhdnWvYnXyJIFnfGW{IEeyJIhzeyCkeTDXV3Qh[XO|YYmsJGlEPTBiPTCwMlAxODB|IN88UU4> NWjtU3F1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA{OzlpPkK0PVAxOzN7PD;hQi=>
HEK293 MoCzSpVv[3Srb36gZZN{[Xl? NVPydWc2XHKjboPy[ZBz\XO|aX;uJI9nKF[SMU[teIFo\2WmIG\EVkApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgbIFz[m:{aX7nJJBEVVhvR1HMOE1PS2:UIHHu[EBOUDFyMDjVRXMqKFhiNITrMWxWSyC{ZYDvdpRmeiCybHHzcYllKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJG5Ed1JicnXjdpVqfG2nboSgZpkh[mW2YT3nZYxi[3Sxc3nkZZNmKHKncH;yeIVzKGenbnWgZoF{\WRibXHtcYFtcWGwIIT3c{1pgWK{aXSgZZN{[XluIFnDOVAhRSByLkCwNFA2KM7:TT6= M{X0e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUi5PFE4Lz5{OUm4PVgyPzxxYU6=
HEK293 NV2x[lJwTnWwY4Tpc44h[XO|YYm= NXy1VXI4XHKjboPhZ5RqfmG2aX;uJI9nKF[SMU[teIFo\2WmIG\EVkApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOgbIFz[m:{aX7nJJBEVVhvR1HMOE1TYFKjbIDoZUBidmRiTVixNFApXUGVKTDYJFR1cy2OVVOgdoVxd3K2ZYKgdIxie22rZDDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCrboTldoFkfGmxbjD3bZRpKFK[UnHsdIhiKGK7IHLleIEu\2GuYXP0c5Nq\GG|ZTDy[ZBwenSncjDn[Y5mKGKjc3XkJI1idW2jbHnhckB1f29vLDDFR|UxKD1iMD6wNFAxPyEQvF2u MnXNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl7OEm4NVcoRjJ7OUi5PFE4RC:jPh?=
HEK293T NVu3elE5TnWwY4Tpc44h[XO|YYm= NGGyS5lC\2:waYP0JIFkfGm4aYT5JIF1KEeDTESgSG5CNWKrbnTpcoch\G:vYXnuJIZ2e2WmIG\EVkApfW6tbn;3ckBwemmpaX6pJIxq\2GwZDDibY5lcW6pIHTvcYFqdiCneIDy[ZN{\WRiaX6gWWFUNWKuYTDISWshOjl|VDDj[YxteyCjc4Pld5Nm\CCjczDi[ZRiNWyjY4ThcYF{\SC2cnHud4NzcXC2aX;uZYwh[WO2aY\heIlwdiCkeTDGVmVVNWKjc3XkJGdmdmWETFH6[ZIh[XO|YYmsJGlEPTBiPTCwMlAxODB7NUOg{txONg>? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODF2NE[5O{c,OzBzNES2PVc9N2F-
HEK293 NWLqelhNTnWwY4Tpc44h[XO|YYm= M4LYRmFod26rc4SgZYN1cX[rdImgZZQhXkSUIDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyClb4TyZY5{\mWldHXkJJdqfGhiTlPvVkBie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjDOR49TKHKnY4L1bZRu\W62IHL5JJR4dy2qeXLybYQh[XO|YYmsJGlEPTBiPTCwMlAxODFizszNMi=> NFXQWG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[xN|QzOCd-Mk[2NVM1OjB:L3G+
HEK293 NEnYPWxHfW6ldHnvckBie3OjeR?= M3fq[VE3KHSxIEK0JIhzew>? MVvB[49vcXO2IHHjeIl3cXS7IHH0JHZFWiCrbjDoeY1idiCKRVuyPVMh[2WubIOgZZN{\XO|ZXSgZZMhfHKjboPjdolxfGmxbnHsJIFkfGm4aYT5JIFnfGW{IEG2JJRwKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTBiPTCwMlAxODF{IN88UU4> NEnw[ZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[xN|QzOCd-Mk[2NVM1OjB:L3G+
ROS 17/2.8 NIPFcG9HfW6ldHnvckBie3OjeR?= M3TRblE3KGi{cx?= NYnoemZiSWO2aY\peJkh[XRiVlTSJIlvKHKjdDDSU3MhOTdxMj64JINmdGy|IHHzd4V{e2WmIHHzJJRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJI9nKDJ2LXj5[JJwgHmuYYPlJIdmdmVicILvcY91\XJiYX\0[ZIhOTZiaILzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OCB;IECuNFAxOiEQvF2u MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTF4N{i5N{c,OTlzNke4PVM9N2F-
osteosarcoma cells NUnHfYlYTnWwY4Tpc44h[XO|YYm= Ml3uRYN1cX[rdImgZZQhXkSUIHnuJJJifCCxc4Tlc5NiemOxbXGgZ4VtdHNiYYPz[ZN{\WRiYYOgNlQucHmmcn;4fYxie2VidILhcpNkemmydHnvckBjgSC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxKD1iMD6wNFAzKM7:TT6= MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzl4MEmyOEc,OTd7NkC5NlQ9N2F-
ROS 17/2.8 NULBc2t3TnWwY4Tpc44h[XO|YYm= M2XldFE3KGi{cx?= M4THVGFkfGm4aYT5JIF1KHKjdDDy[YNwdWKrbnHueEBnfWyuIHzlcod1cCCYRGKg[ZhxemW|c3XkJIlvKHKjdDDSU3MhOTdxMj64JINmdGy|IITyZY5{\mWldHXkJJdqfGhiMkStbJllem:6eXzhd4Uh\2WwZTDwdo9ud3SncjDhd5Nme3OnZDDhd{B1emGwc3PybZB1cW:wYXygZYN1cX[jdHnvckBi\nSncjCxOkBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5yMECyJO69VS5? NXTiSY8xRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi3NlIyOzBpPkG4O|IzOTNyPD;hQi=>
ROS 17/2.8 M3LLO2Z2dmO2aX;uJIF{e2G7 MUOxOkBpenN? NE\mZYVC[3Srdnn0fUBifCC{YYSgdoVkd22kaX7hcpQh\nWubDDs[Y5ofGhiVlTSJIV5eHKnc4Pl[EBqdiC{YYSgVm9UKDF5L{KuPEBk\WyuczD0doFve2[nY4Tl[EB4cXSqIEK0MYh6\HKxeInsZZNmKGenbnWgdJJwdW:2ZYKgZZN{\XO|ZXSgZZMhfHKjboPjdolxfGmxbnHsJIFkfGm4YYTpc44h[W[2ZYKgNVYhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiS3mgQUAxNjByMEKg{txONg>? NHnNNIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUGwOVY4Pyd-MkGxNFU3Pzd:L3G+
ROS 17/2.8 NHLYOlNHfW6ldHnvckBie3OjeR?= NFPaepcyPiCqcoO= M3TwfWFod26rc4SgZYN1cX[rdImgZZQhemG2IG\EVkBqdiCUT2OgNVcwOi56IHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghS3myMkThNUBz\XCxcoTldkBxdGG|bXnkJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIFP5dFI1[TFidILhcpNkemmydHnvckBi\nSncjCxOkBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwJF0hOC5yMECyJO69VS5? NXjDOGw4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNVg6OThpPkKyNFE5QTF6PD;hQi=>
osteosarcoma cells NGP0WHhHfW6ldHnvckBie3OjeR?= NVnaUZBJUW6mdXP0bY9vKG:oIG\EVk1u\WSrYYTl[EAzPC2qeXTyc5h6dGG|ZTD0doFve2O{aYD0bY9vKGmwIILheEBwe3Snb4PhdoNwdWFiY3XscJMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGTDVyIE2gNE4xODB{IN88UU4> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTlyMkKzOUc,OjF7MEKyN|U9N2F-
osteosarcoma cells M{nBTGZ2dmO2aX;uJIF{e2G7 MnToWJJidnOjY4TpeoF1cW:wIH;mJHZFWiCrbjDyZZQhd3O2ZX;zZZJkd22jIHPlcIx{KGG|c3Xzd4VlKGG|IEK0MYh6\HKxeInsZZNmKHS{YX7zZ5JqeHSrb37hcEBi[3Srdnn0fUBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVFPTBiPTCwMlAxODJizszNMi=> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ|MES0OEc,OjZ4M{C0OFQ9N2F-
osteosarcoma cells M4jjUGZ2dmO2aX;uJIF{e2G7 MVWxOkBpenN? NF7oZlVKdmirYnn0bY9vKG:oIG\EVk1qdmS3Y3XkJFI1NWi7ZILvfJlt[XOnIITyZY5{[3KrcITpc44hcW5icnH0JI9{fGWxc3HyZ49u[SClZXzsd{Bi\nSncjCxOkBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHREWwJF0hOC5yMECyJO69VS5? MoPrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2OUCwNVAoRjJ{NEmwNFExRC:jPh?=
osteosarcoma cells NVu2dlFQTnWwY4Tpc44h[XO|YYm= NInl[o1C[3Srdnn0fUBifCCYRGKgbY4hemG2IH;zeIVwe2G{Y3;tZUBk\WyuczDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZiMkStbJllem:6eXzhd4UhemWyb4L0[ZIh\2WwZTD0doFve2O{aYD0bY9vKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3MDC9JFAvODByMzFOwG0v M{jVbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF7OEG5O|AzLz5zOUixPVcxOjxxYU6=
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C3H10T1/2 Mo\sSpVv[3Srb36gZZN{[Xl? NXK4ZpNZOC53IIXN NF;tTJczPCCqcoO= NVz2UoYxTW[oZXP0JI9vKEO\UEK0RVEhWk6DIHzleoVtKGmwIH7vck11[XKpZYTpcoche2mUTlGgeJJm[XSnZDDtc5V{\SCFM1ixNHQyNzJiY3XscJMh[XRiMD61JJVOKGGodHXyJFI1KGi{czDifUByWEOUIHHuZYx6e2m| MnHSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5M{C5PFQoRjJ2N{OwPVg1RC:jPh?=
C3H10T1/2 NVfBSmlHTnWwY4Tpc44h[XO|YYm= NWj5Oop1OC53IIXN NYT5SFBLOjRiaILz NEHOPXNKdmirYnn0bY9vKG:oIHjl[IdmcG:pIIPp[45idGmwZzDwZZRpf2G7IHnuJI5wdi22YYLn[ZRqdmdic3nSUmEhfHKnYYTl[EBud3W|ZTDDN2gyOFRzL{KgZ4VtdHNiYYPz[ZN{\WRiYYOg[YZn\WO2IH;uJHZFWiCneIDy[ZN{cW:wIHH0JFAvPSC3TTDh[pRmeiB{NDDodpMh[nlicWDDVkBidmGueYPpdy=> M1rSfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{OwPVg1Lz5{NEezNFk5PDxxYU6=
C3H10T1/2 MV\GeY5kfGmxbjDhd5NigQ>? Mn3DNE42KHWP NXXvfmpsOjRiaILz NHLTNlFKdmirYnn0bY9vKG:oIHjl[IdmcG:pIIPp[45idGmwZzDwZZRpf2G7IHnuJHZFWi2tbn;jb4Rwf25ibX;1d4UhSzOKMUDUNU8zKGOnbHzzJIF{e2W|c3XkJIF{KGWoZnXjeEBwdiCYRGKg[ZhxemW|c3nvckBifCByLkWgeW0h[W[2ZYKgNlQhcHK|IHL5JJFRS1JiYX7hcJl{cXN? MkHiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR5M{C5PFQoRjJ2N{OwPVg1RC:jPh?=
LX2 NEPSOGVHfW6ldHnvckBie3OjeR?= MYGxNFAhdk1? MmDGNlQhcHK| NXnpdYp2XHKjboPhZ5RqfmG2aX;uJI9nKF[GUjDpckBpfW2jbjDMXFIh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDUS2Zj\XSjMT3pcoR2[2WmIFPPUFFCOSCvUl7BJIV5eHKnc4Ppc44h[XRiMUCwJI5OKGGodHXyJFI1KGi{czDifUBSNVCFUjDhcoFtgXOrcx?= M1LsUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyM{WwPVk6Lz5|MEO1NFk6QTxxYU6=
ROS 17/2.8 M2LnXGZ2dmO2aX;uJIF{e2G7 MV[xOkBpenN? MmDhTY5lfWO2aX;uJI9nKF[GUjD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliYYPz[ZN{\WRiYYOgZYN1cX[jdHnvckBw\iB{ND3ofYRzd3i7bHHz[UBo\W6nIHX4dJJme3Orb36gbY4hemG2IGLPV{AyPy9{LkigZ4VtdHNiYX\0[ZIhOTZiaILzJIJ6KGy3Y3nm[ZJie2VicnXwdpRmeiCjc4PhfS=> NFjXeHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkW3OFkzOSd-Mk[1O|Q6OjF:L3G+
HL60 MoHTSpVv[3Srb36gZZN{[Xl? MlzBN|AhfG9iMUCwNEBvVQ>? MnnIOFghcHK| NVXIUZZjUW6mdXP0bY9vKG:oIHPlcIwh\GmoZnXy[Y51cWG2aX;uJIlvKGi3bXHuJGhNPjBiY3XscJMh[XO|ZYPz[YQh[XNibXH0eZJqdmdibX;ydIhwdG:paXPhcEBkcGGwZ3XzJIF1KDNyIITvJFExODBibl2gZYZ1\XJiNEigbJJ{KGK7IGfybYdpfCe|LVfp[Y1{[SC|dHHpcolv\y2kYYPl[EBnd3K2eTDtbYNzd3Olb4DpZ{B3cWW5IHHzd4F6 MmrjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzMkexOFkoRjJ3MUK3NVQ6RC:jPh?=
SW480-ADH M1j1Z2Z2dmO2aX;uJIF{e2G7 M2jjdFExOCCwTR?= MYK0PEBpenN? Mo[yTY5lfWO2aX;uJI9nKGi3bXHuJHNYPDhyLVHETEBk\WyuIHTp[oZmemWwdHnheIlwdiCjc4Pld5Nm\CCjczDmc5Ju[XSrb36gc4Yh[2:vcHHjeEBmeGm2aHXsbY9q\CCrc3zhcoR{KG:oIHjp[4htgSCjZHjldoVvfCClZXzsd{BifCBzMDCnMVchVSCjZoTldkA1QCCqcoOgZpkheGijc3WtZ49vfHKjc4SgcYlkem:|Y3;wfS=> NI\GbWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm4PVM4QSd-MkK5PFk{Pzl:L3G+
SW480-ADH M1;TdmZ2dmO2aX;uJIF{e2G7 NELwbJcyOCCwTR?= MmXIOFghcHK| NFjDNWxKdmS3Y4Tpc44hd2ZiaIXtZY4hW1d2OECtRWRJKGOnbHyg[Iln\mW{ZX70bYF1cW:wIHHzd4V{e2WmIHHzJIZwem2jdHnvckBw\iClb33wZYN1KGWyaYTo[Yxqd2mmIHnzcIFv\HNib3[gbIlocGy7IHHkbIVz\W62IHPlcIx{KGG2IEGwJEcuQCCPIHHmeIVzKDR6IHjyd{BjgSCyaHHz[U1kd262cnHzeEBucWO{b4Pjc5B6 M2qyVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUi5N|c6Lz5{Mkm4PVM4QTxxYU6=
MCF7 NEXMc5dCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXv1bHM1OTByIH7N MVi0PEBpenN? Mn:5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPQ1[3JINmdGy|IHH0JFExKCdvNzDNJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmgdoVt[XSrdnWgeI8hfW62cnXheIVlNWOxboTyc4w> MmDrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7OEmzO|koRjJ{OUi5N|c6RC:jPh?=
CLL MkT3SpVv[3Srb36gZZN{[Xl? NXHLWpdbOTByIH7N MW[yOEBpenN? MUDF[oZm[3Rib36gR3lROjSDMTDpckBpfW2jbjDwdolu[XK7IFPMUEBk\WyuczDhd5Nme3OnZDDhd{BqdmO{ZXHz[UBqdiCYRGKtdoVofWyjdHXkJGdCTER2NXHsdIhiKG2UTlGg[ZhxemW|c3nvckBifCBzMECgcm0hcW6ldXLheIVlKG[xcjCyOEBpenNiYomgdZVidnSrdHH0bZZmKFKWLWDDVkBu\XSqb3S= NHzlOmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUG0PFM6Oid-MkWxOFg{QTJ:L3G+
CLL MVjGeY5kfGmxbjDhd5NigQ>? NIGzZWsyODBibl2= MoHCNlQhcHK| MmPJSYZn\WO2IH;uJGN[WDJ2QUGgbY4hcHWvYX6gdJJqdWG{eTDDUGwh[2WubIOgZZN{\XO|ZXSgZZMhcW6lcnXhd4UhcW5iVlTSMZJm\3WuYYTl[EBETEuQMVGgcXJPSSCneIDy[ZN{cW:wIHH0JFExOCCwTTDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCzdXHueIl1[XSrdnWgVnQuWEOUIH3leIhw\A>? Mlj3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjVzNEizPVIoRjJ3MUS4N|kzRC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
CyclinD1 ; 

PubMed: 28643892     


Immunoblot analysis of cyclinD1 in AXT cells treated with the indicated concentrations of calcitriol for 14 h. 

IRE1α / p-eIF2α / eIF2α / Atf4 / CHOP ; 

PubMed: 28643892     


Immunoblot analysis of Ire1a and total or phosphorylated (p-) forms of eIf2a, Atf4 and Chop in AXT cells treated with 5 lM calcitriol for the indicated times.

p-PERK / PERK ; 

PubMed: 28643892     


Immunoblot analysis of total or phosphorylated (p-) forms of Perk and Atf4 in AXT cells treated with 5 lM calcitriol for the indicated times or with 1 lM thapsigardin (Thap) for 1.5 h.

FGFR1 / FGFR2 / FGFR3 / FGFR4 ; 

PubMed: 29776409     


Representative immunoblots and average data (n = 6) of FGFR1, FGFR2, FGFR3, and FGFR4 from control and calcitriol (1 and 10 nM)-treated HL-1 cells.

Wnt10b / Wnt16 ; 

PubMed: 30149605     


Wnt10b and Wnt 16 protein expression in calcitriol-treated osteoclasts. With calcitriol treatment of 10 to 100 nM overnight, Western blot analysis showed a significant increase in Wnt 10b expression. Wnt 16 expression in osteoclasts after different doses of calcitriol was not significantly different at the protein level. Actin protein served as a loading control. 

28643892 29776409 30149605

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

溶解度 (25°C)

体外 DMSO 83 mg/mL (199.21 mM)
Water Insoluble
Ethanol '''83 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 416.64
化学式

C27H44O3

CAS号 32222-06-3
储存条件 3年 -20°C 粉状
别名 Topitriol, 1,25-Dihydroxyvitamin D3

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04551170 Recruiting Drug: Theophylline|Drug: Placebo Pseudohypoparathyroidism|Albright Hereditary Osteodystrophy|Pseudohypoparathyroidism Type 1a Vanderbilt University Medical Center July 13 2020 Phase 2
NCT03029429 Recruiting Drug: Theophylline|Drug: Placebos Pseudohypoparathyroidism|Albright Hereditary Osteodystrophy Vanderbilt University Medical Center|Harvard University September 1 2018 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项
免费分装抑制剂
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID