PDE5 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S4683 Sildenafil Mesylate

Sildenafil Mesylate是Sildenafil的甲磺酸盐形式,Sildenafil是Phosphodiesterase 5的抑制剂。

Selective
S2515 Vardenafil HCl Trihydrate

Vardenafil HCl Trihydrate是一种新型PDE抑制剂,作用于PDE5和PDE1,IC50分别为0.7和180 nM。

Selective PDE5, IC50: 0.7 nM
S5957 Vardenafil hydrochloride

Vardenafil (BAY38-9456, Levitra, Staxyn) hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase (PDE) with IC50 of 0.7 nM, 11 nM and 180 nM for PDE5, PDE6 and PDE1, respectively.

Selective PDE5, IC50: 0.7 nM
S4019 Avanafil

Avanafil是一种高度选择性PDE5抑制剂,IC50为1nM.

Selective PDE5, IC50: 1 nM
S1512 Tadalafil (IC351)

Tadalafil是一种PDE-5抑制剂,无细胞试验中IC50为1.8 nM。Tadalafil对PDE5的选择性比对PDEs家族中其他成员高9000倍以上,除了PDE11。它能部分抑制PDE11

Selective PDE5, IC50: 1.8 nM
S4684 Sildenafil

Sildenafil是Phosphodiesterase 5抑制剂,其IC50为5.22 nM。

Selective PDE5, IC50: 5.22 nM
S2312 Icariin

Icariin是一种cGMP特异性的PDE5抑制剂,IC50为0.432 μM,作用于PDE5比作用于PDE4选择性高167倍。

Selective PDE5, IC50: 0.432 μM
S1431 Sildenafil Citrate

Sildenafil Citrate,一种环鸟苷酸单磷酸盐(cGMP)特异性的Ⅵ型磷酸二酯酶(PDE5)选择性抑制剂,对勃起功能障碍具有良好的耐受性和较高作用效果。

Pan PDE5, IC50: 3.5 nM
S6433 Udenafil

Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs.

Pan PDE5, IC50: 8.25 nM
S4837 Ibudilast

Ibudilast (KC-404, AV411, MN166) is a relatively non-selective phosphodiesterase inhibitor with anti-inflammatory and neuroprotective activities.

Pan PDE5, IC50: 2.2 μM
S2320 Luteolin

Luteolin是一种非选择性的PDE抑制剂,作用于PDE1-5Ki分别为15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM和9.5 μM。Phase 2.

Pan PDE5, Ki: 9.5 μM
S5836 IBMX

IBMX (Isobutylmethylxanthine, 1-Methyl-3-Isobutylxanthine) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist.

Pan PDE5, IC50: 31.7 μM