BI 2536

目录号:S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI 2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM,比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。

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RMB 1978.87 现货
RMB 981.57 现货
RMB 1704.35 现货
RMB 5492.59 现货
RMB 8160.83 现货
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客户购买Selleck的此次产品后发表的文献54篇:

客户使用该产品的12个实验数据:

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like cells after treatment with BI 2536 for 24 and 48 hours, respectively.

    Oncotarget, 2017, 8(23):37633-37645. BI 2536 purchased from Selleck.

    Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

  • J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

    Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

产品安全说明书

PLK抑制剂选择性比较

生物活性

产品描述 BI 2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM,比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。
特性 BI 2536是第一个有效的Plk1选择性抑制剂,抑制 Plk1的标记。
靶点
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性,只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶(IC50>10 μM)选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞,抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化,抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴,及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞,使细胞周期停在G2/M期, 随后DNA分解及凋亡,且累积断裂的PARP p85片段,这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长,EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖,EC50为12-31 nM。[1] BI 2536 抑制Plk1,降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力,EC50为1.4-5.6 nM。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 M4r5O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[xepVKSzVyPUCuNFA4PzZizszN M3rZbXNCVkeHUh?=
ACN M3S0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqwOo5EUUN3ME2wMlAxQDR|IN88US=> MoHFV2FPT0WU
TE-8 M1riPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPNTWk1UUN3ME2wMlAxQTRzIN88US=> MlfyV2FPT0WU
LC-2-ad NX22ZWtvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEGwPVMh|ryP MorXV2FPT0WU
ALL-PO M1i1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HHVWlEPTB;MD6wNVMh|ryP M3i3cHNCVkeHUh?=
EW-16 M3TyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7TcphtUUN3ME2wMlAyOzN4IN88US=> MYDTRW5ITVJ?
KM12 MkXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF20U|VKSzVyPUCuNFE{PDhizszN NYj1XXlXW0GQR1XS
GI-1 M3\a[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3UbmhJUUN3ME2wMlAyOzh|IN88US=> NHfoOpBUSU6JRWK=
LS-411N NWrBWlZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH3TWM2OD1yLkCxOFA4KM7:TR?= MmryV2FPT0WU
ES8 MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMEG0PVQh|ryP NWDwb|dJW0GQR1XS
SNU-C2B M{LuWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLtTlVwUUN3ME2wMlAyPTJ4IN88US=> NVSyR5NvW0GQR1XS
CESS NYfRWnUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPwNWdKSzVyPUCuNFE3ODJizszN NFzyNJRUSU6JRWK=
697 NFiw[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\kWWY5UUN3ME2wMlAyPjZ6IN88US=> NWLGUG1FW0GQR1XS
NCI-H1963 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\hOZpKSzVyPUCuNFE3PzNizszN M{\m[nNCVkeHUh?=
IA-LM NIrTZpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEG2PFgh|ryP M3znV3NCVkeHUh?=
SW954 NXfaUmJ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMEG3NFUh|ryP NW\INYRIW0GQR1XS
RL95-2 NEjNT3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzTUlFzUUN3ME2wMlAyPzN6IN88US=> MlOxV2FPT0WU
LXF-289 NVfBepNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3jeINKSzVyPUCuNFE4PyEQvF2= Mlf6V2FPT0WU
OCUB-M NV;KZXBLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFz6PZFKSzVyPUCuNFE5OjZizszN M3\3R3NCVkeHUh?=
RKO NIPRcmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDHTWM2OD1yLkCxPVg4KM7:TR?= NH\TTnZUSU6JRWK=
LOUCY MkTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMEKwOUDPxE1? MmHKV2FPT0WU
NOS-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHETWM2OD1yLkCyNFk{KM7:TR?= NFPPV|dUSU6JRWK=
A4-Fuk MnzMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHvTWM2OD1yLkCyNlE5KM7:TR?= NXqxSYN1W0GQR1XS
A388 M3nhTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvUc3pNUUN3ME2wMlAzOjJ5IN88US=> NXPiOoJmW0GQR1XS
TE-9 M4T3WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT0O2dKSzVyPUCuNFIzPjFizszN NGDYXW9USU6JRWK=
KURAMOCHI NGP6W4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7RblhTUUN3ME2wMlAzOjh3IN88US=> MmfoV2FPT0WU
KALS-1 NIfVc5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTKTWM2OD1yLkCyN|M5KM7:TR?= MmDQV2FPT0WU
HOP-62 NWXTc5RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEK0NkDPxE1? NHLld4RUSU6JRWK=
RPMI-8402 NYfyNFZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWT0fow4UUN3ME2wMlAzPTB6IN88US=> M3H2N3NCVkeHUh?=
TE-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTBwMEK1NVIh|ryP M4j0N3NCVkeHUh?=
CCRF-CEM NEPVdWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMEK1OFMh|ryP NXjBWmtMW0GQR1XS
HUTU-80 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIW3WIFKSzVyPUCuNFI3OjRizszN NGjPe25USU6JRWK=
NCI-H1648 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nXU2lEPTB;MD6wNlY1PyEQvF2= MlvOV2FPT0WU
HCE-4 MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;iTWM2OD1yLkCyOlgzKM7:TR?= NVXrRlZbW0GQR1XS
ETK-1 M3TkXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDJVGNKSzVyPUCuNFI4OzZizszN MULTRW5ITVJ?
TE-15 Mn:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjCUFVxUUN3ME2wMlAzPzN6IN88US=> M3HCVnNCVkeHUh?=
BE-13 M2nTdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXnT2dKSzVyPUCuNFI4PCEQvF2= NEO0dFNUSU6JRWK=
KE-37 MnXlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMEK3OFEh|ryP Mn\5V2FPT0WU
NCI-H1355 NIe3fXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{i1V2lEPTB;MD6wNlc5OyEQvF2= NIrweplUSU6JRWK=
TE-11 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfCTHFKSzVyPUCuNFI5ODlizszN NH;ubVBUSU6JRWK=
BL-70 NXrMTXNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEK4OVch|ryP M4DqSnNCVkeHUh?=
ES6 NFX5dJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEK4PFEh|ryP NYDB[|ZqW0GQR1XS
GT3TKB NEH0fo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEK5OVMh|ryP M3XpbXNCVkeHUh?=
LB647-SCLC Mo\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojjTWM2OD1yLkCzNVk2KM7:TR?= NH;5fJZUSU6JRWK=
NB13 NVjke3BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLaTWM2OD1yLkCzN|E3KM7:TR?= MmHjV2FPT0WU
ST486 MmfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmezTWM2OD1yLkCzN|M4KM7:TR?= MXfTRW5ITVJ?
NCI-H82 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;jdVJKSzVyPUCuNFM{PDNizszN MX;TRW5ITVJ?
NTERA-S-cl-D1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfkOWVEUUN3ME2wMlA{Ozl7IN88US=> NF3ZZYlUSU6JRWK=
ES4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LkeWlEPTB;MD6wN|Q3OyEQvF2= NWTVUGFMW0GQR1XS
SK-NEP-1 NFO4U5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwMEO0PVkh|ryP M1S3UnNCVkeHUh?=
Becker NE[4blRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3oTWM2OD1yLkCzOVU2KM7:TR?= NHvPbFJUSU6JRWK=
A101D NXzndYM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3m1PGlEPTB;MD6wN|c1QCEQvF2= NH7LfHpUSU6JRWK=
SK-UT-1 NIfBOmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEO3O|Qh|ryP MnriV2FPT0WU
SW982 NXv1cG1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPO[XlVUUN3ME2wMlA{PzlizszN NIPl[4JUSU6JRWK=
TE-10 MojRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3Qb3JKSzVyPUCuNFQxPDZizszN NEjzbXNUSU6JRWK=
OVCAR-4 NWe5N5dnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2r6O2lEPTB;MD6wOFA2QSEQvF2= MoTtV2FPT0WU
KP-N-YS MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\aV5NKUUN3ME2wMlA1ODh3IN88US=> M133T3NCVkeHUh?=
BL-41 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP0WmVbUUN3ME2wMlA1OTJ3IN88US=> M3PnR3NCVkeHUh?=
MZ1-PC NYi0OHkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjxSoZyUUN3ME2wMlA1OTJ5IN88US=> NVy3T|ZXW0GQR1XS
PF-382 NUXjfJFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\pTWM2OD1yLkC0NVk5KM7:TR?= M37hdXNCVkeHUh?=
MOLT-13 MlHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LVZmlEPTB;MD6wOFI{QCEQvF2= MmDTV2FPT0WU
HCC1599 M3faUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jTemlEPTB;MD6wOFI2QCEQvF2= NUTvUXhwW0GQR1XS
IST-MEL1 MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LQc2lEPTB;MD6wOFQ1OiEQvF2= NFzSRYdUSU6JRWK=
LU-139 NWDxeJJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfUNG5KSzVyPUCuNFQ1PDJizszN NWXhO3hbW0GQR1XS
MS-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLLbZpuUUN3ME2wMlA1PzBzIN88US=> M37hfHNCVkeHUh?=
MFH-ino NVL3c4J2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\TfFVbUUN3ME2wMlA2ODB|IN88US=> NIW5b21USU6JRWK=
IMR-5 Mmn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXYb4Q3UUN3ME2wMlA2ODJzIN88US=> NYXmWHdqW0GQR1XS
TE-5 NXfMU5RlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljrTWM2OD1yLkC1NFY{KM7:TR?= Mn7aV2FPT0WU
DJM-1 M1LYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzMSWhiUUN3ME2wMlA2OTR{IN88US=> NYD0Z2tkW0GQR1XS
NB17 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjZboN3UUN3ME2wMlA2OjB5IN88US=> MlSxV2FPT0WU
KARPAS-45 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[0TWM2OD1yLkC1N|U5KM7:TR?= NEPrUWlUSU6JRWK=
TGBC1TKB NXnBWVdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXNNoV{UUN3ME2wMlA2PDB3IN88US=> NWPEPZRWW0GQR1XS
ML-2 MoLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTvbWNWUUN3ME2wMlA2PDF2IN88US=> MWrTRW5ITVJ?
no-10 NFnVOFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn35TWM2OD1yLkC1OFc1KM7:TR?= MYTTRW5ITVJ?
CTV-1 NEnObJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMEW1NFIh|ryP MljnV2FPT0WU
SJSA-1 NHGxfHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NESyRo1KSzVyPUCuNFU2OiEQvF2= MYjTRW5ITVJ?
HC-1 NFXHXIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3pZYpKSzVyPUCuNFU2QTdizszN MljxV2FPT0WU
TE-12 NXjsN2l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHvfI5KSzVyPUCuNFU3OTNizszN M4DOZ3NCVkeHUh?=
KY821 Mn;DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrKU5ROUUN3ME2wMlA2PjN{IN88US=> NYrGeVBxW0GQR1XS
TALL-1 M2X1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rR[2lEPTB;MD6wOVcxQCEQvF2= MUDTRW5ITVJ?
DEL NFrlOllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHjfGJGUUN3ME2wMlA2PzB7IN88US=> NUjzcJRRW0GQR1XS
TE-6 NHnINoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEW3NlIh|ryP MkDwV2FPT0WU
SK-LMS-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHuOnRKSzVyPUCuNFU5ODVizszN M4PWV3NCVkeHUh?=
EW-1 Mk\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXYPI5VUUN3ME2wMlA2QDN5IN88US=> M{OyWnNCVkeHUh?=
8-MG-BA M2nldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LWO2lEPTB;MD6wOVg2OSEQvF2= MXPTRW5ITVJ?
NALM-6 Mn3VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rvNGlEPTB;MD6wOVk4OyEQvF2= NH\ZcGlUSU6JRWK=
LB771-HNC MnnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEW5O|kh|ryP NUnBeFBVW0GQR1XS
HT-144 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLqPJhKSzVyPUCuNFYyOyEQvF2= M3fPS3NCVkeHUh?=
KM-H2 NHPsc41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwME[yNlEh|ryP Mn;XV2FPT0WU
SF268 NX7lV4h{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwME[yPFYh|ryP NF\LNIhUSU6JRWK=
RS4-11 NFnSV5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33LSmlEPTB;MD6wOlMxPCEQvF2= MnjTV2FPT0WU
MHH-PREB-1 MorVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{K1dWlEPTB;MD6wOlMyQSEQvF2= NF[zOGtUSU6JRWK=
ATN-1 MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XrcGlEPTB;MD6wOlM1PSEQvF2= NXfPfoh4W0GQR1XS
BB30-HNC MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD4UXEzUUN3ME2wMlA3PDN4IN88US=> M1nWcnNCVkeHUh?=
CPC-N M1nhUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnBe|BOUUN3ME2wMlA3PTJ2IN88US=> M2fyOnNCVkeHUh?=
NB1 M4ftVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwME[2NVMh|ryP M1iwbXNCVkeHUh?=
KS-1 Mk[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwME[3OFgh|ryP NYXLelRjW0GQR1XS
RXF393 NYrtSJZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwME[3OlQh|ryP NETnR21USU6JRWK=
IST-SL2 NFOzU|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMEewNFQh|ryP NWfhS3diW0GQR1XS
GI-ME-N MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMEeyPFYh|ryP NEDtTHlUSU6JRWK=
VA-ES-BJ NEO1bJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvMTWM2OD1yLkC3OFc2KM7:TR?= NG\PfmZUSU6JRWK=
NCI-H1581 NEf6W5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEe0O|gh|ryP MYnTRW5ITVJ?
U-266 M33sZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nJeGlEPTB;MD6wO|Q6PyEQvF2= MoHSV2FPT0WU
DMS-114 NIDHfVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEe1Nlgh|ryP M4XLbXNCVkeHUh?=
NCI-H187 MmS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13TSmlEPTB;MD6wO|czPiEQvF2= M4LtfXNCVkeHUh?=
SW962 M2[yTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;oeGlEPTB;MD6wO|g{QSEQvF2= MWjTRW5ITVJ?
MONO-MAC-6 NHvHWo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXvUWVLUUN3ME2wMlA4QTh4IN88US=> NX;LNYhzW0GQR1XS
MOLT-16 M{LJSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDYfVJ1UUN3ME2wMlA5OTJzIN88US=> MXXTRW5ITVJ?
KNS-42 NXTxV5R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\tTWM2OD1yLkC4NVYyKM7:TR?= MWfTRW5ITVJ?
CMK NUXzO2tDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYewUZZJUUN3ME2wMlA5OjJ3IN88US=> M{jWb3NCVkeHUh?=
Ramos-2G6-4C10 MlPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMEiyNlUh|ryP NY[3UJh4W0GQR1XS
Daudi M{HhdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mke0TWM2OD1yLkC4NlU3KM7:TR?= MXnTRW5ITVJ?
NCI-H510A NU\xUplXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnyzTWM2OD1yLkC4N|M3KM7:TR?= M1zHdHNCVkeHUh?=
LB831-BLC MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMEi1OlEh|ryP NFjPcnlUSU6JRWK=
HEL MnjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\NXo4yUUN3ME2wMlA5PjZ6IN88US=> MlTGV2FPT0WU
LU-134-A NITj[G1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHITWM2OD1yLkC4O|A5KM7:TR?= MlmxV2FPT0WU
NCI-H1694 NI\YeWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXWzdJVzUUN3ME2wMlA5PzR2IN88US=> NXrFT3AxW0GQR1XS
KGN NUH4UVhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHCPYhIUUN3ME2wMlA5PzV7IN88US=> NEP5[|ZUSU6JRWK=
A253 M2LGeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjrdmtKSzVyPUCuNFg5OjJizszN NE\VV2FUSU6JRWK=
DG-75 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj6NYZKSzVyPUCuNFg6OjJizszN M{jpfXNCVkeHUh?=
MOLT-4 NGPBRXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TlVGlEPTB;MD6wPFk5OyEQvF2= MUHTRW5ITVJ?
NCI-SNU-5 M37COmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV:w[FdoUUN3ME2wMlA6OjV6IN88US=> NF\6eG5USU6JRWK=
ONS-76 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfwTWM2OD1yLkC5Nlc3KM7:TR?= NHHCZ4tUSU6JRWK=
NCI-H446 Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[wPGlEPTB;MD6wPVQ3OiEQvF2= NUL1Omp[W0GQR1XS
COR-L279 NYTwbW1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rVfWlEPTB;MD6wPVU2PiEQvF2= MV;TRW5ITVJ?
Calu-6 NWLJVHUyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMEm1PVgh|ryP MU\TRW5ITVJ?
BC-3 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFuyOWZKSzVyPUCuNFk3PjJizszN MVnTRW5ITVJ?
NCI-H2126 MmHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEm3PVEh|ryP NXr2NHRLW0GQR1XS
NCI-H1882 NEnzVINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILud2hKSzVyPUCuNFk5ODlizszN NV3EUGU6W0GQR1XS
BB65-RCC MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfJVHVJUUN3ME2wMlExOjl2IN88US=> NXrEdVd5W0GQR1XS
DU-4475 NIrxe5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PET2lEPTB;MD6xNFQxPyEQvF2= Mke3V2FPT0WU
NCI-H526 NInObHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTBwMUC0OEDPxE1? MX3TRW5ITVJ?
NEC8 M4iyVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfMTWM2OD1yLkGwOVI2KM7:TR?= M1vMbnNCVkeHUh?=
NCI-H1304 NEXpR2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2CydGlEPTB;MD6xNFU6PCEQvF2= M4njZnNCVkeHUh?=
L-540 M4LHd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLZXIFKSzVyPUCuNVA4ODhizszN NVvwc3p7W0GQR1XS
NCI-SNU-16 MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnn3TWM2OD1yLkGwO|QzKM7:TR?= MorIV2FPT0WU
HD-MY-Z NWnRVWpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHrcFhuUUN3ME2wMlExQDV4IN88US=> MVzTRW5ITVJ?
K-562 NH;aTY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGW0PXdKSzVyPUCuNVA5PThizszN MV;TRW5ITVJ?
JAR M1\3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1Lp[mlEPTB;MD6xNFkzPSEQvF2= MUfTRW5ITVJ?
MZ2-MEL NI\aRWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMUGwOUDPxE1? M{LjfHNCVkeHUh?=
L-363 MoH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUCwOZhSUUN3ME2wMlEyODd7IN88US=> MX\TRW5ITVJ?
BV-173 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX71[5JCUUN3ME2wMlEyOjR|IN88US=> NIe4NmlUSU6JRWK=
NCI-H524 MnLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnLT497UUN3ME2wMlEyOjd2IN88US=> MWPTRW5ITVJ?
EoL-1-cell MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFK3UWVKSzVyPUCuNVE3PzJizszN M2XiWHNCVkeHUh?=
K052 M4XJUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPGcFlKSzVyPUCuNVE4OTJizszN NELZUFhUSU6JRWK=
TK10 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPmVmRKSzVyPUCuNVE4OjhizszN NICzXY5USU6JRWK=
KU812 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\tTWM2OD1yLkGyNFQ1KM7:TR?= M2fBWHNCVkeHUh?=
RPMI-8226 NYnMdGhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[yO3ptUUN3ME2wMlEzODV{IN88US=> M3\MN3NCVkeHUh?=
MZ7-mel MkXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDsTWM2OD1yLkGyNlM4KM7:TR?= MnTlV2FPT0WU
SK-PN-DW NIXtXHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofHTWM2OD1yLkGyNlg4KM7:TR?= NXfoXJN2W0GQR1XS
SR MnLLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTBwMUK0OFEh|ryP NVvseVdnW0GQR1XS
RPMI-6666 NIPKb4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\pTWM2OD1yLkGyO|Q{KM7:TR?= MX;TRW5ITVJ?
no-11 NImzSmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3O2fGlEPTB;MD6xNlg3QSEQvF2= MnzZV2FPT0WU
EW-3 MkXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXz0SlFGUUN3ME2wMlEzQDl|IN88US=> M2nJW3NCVkeHUh?=
LAMA-84 NVn6dHp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMUOxPFch|ryP NXeyXndbW0GQR1XS
HT M1Tmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfhZWxnUUN3ME2wMlE{PTd2IN88US=> NGfN[FBUSU6JRWK=
KP-N-RT-BM-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLHXJZJUUN3ME2wMlE{PjF{IN88US=> M1\WfXNCVkeHUh?=
NCI-H747 NEj1UXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrFO4hKSzVyPUCuNVM4KM7:TR?= MULTRW5ITVJ?
NCCIT Mlm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\XXGlEPTB;MD6xN|k{QSEQvF2= MkKxV2FPT0WU
MLMA MofNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP3bYJKSzVyPUCuNVQyPjdizszN NH7se2lUSU6JRWK=
LP-1 MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknsTWM2OD1yLkG0NlQh|ryP MlTxV2FPT0WU
CAL-148 NWHOUVZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\xUJpKSzVyPUCuNVQ1QDNizszN M1WyVnNCVkeHUh?=
GB-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMUS1NlYh|ryP M1Xze3NCVkeHUh?=
COR-L88 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTBwMUS4NFIh|ryP MWnTRW5ITVJ?
NKM-1 NV2yTXVsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTBwMUS5NFYh|ryP MXrTRW5ITVJ?
NB5 NEfwOJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLCVHR4UUN3ME2wMlE2PDZ{IN88US=> MYnTRW5ITVJ?
SH-4 NVy3N2tLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMUW0OlYh|ryP MnXHV2FPT0WU
EM-2 NY\JdmtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFu0ZlVKSzVyPUCuNVU1PjdizszN NVPMV5hsW0GQR1XS
TGBC24TKB MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1T5cGlEPTB;MD6xOVY2QSEQvF2= MX7TRW5ITVJ?
SCLC-21H MmrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[5b2NKSzVyPUCuNVU4ODJizszN M3rkZ3NCVkeHUh?=
COLO-684 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7jW|BKSzVyPUCuNVU4OjFizszN NX7vOIJQW0GQR1XS
KINGS-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnMNppHUUN3ME2wMlE2QTFizszN NY\1e2ZqW0GQR1XS
LS-123 M2LWdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\2SmlEPTB;MD6xOVkyPyEQvF2= NIXqUXFUSU6JRWK=
MC116 Mm\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkT0TWM2OD1yLkG2NVU5KM7:TR?= Ml[xV2FPT0WU
SU-DHL-1 M33GSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jacmlEPTB;MD6xOlIxPiEQvF2= M4fZPXNCVkeHUh?=
NCI-H64 NWTWOFdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMU[zOFch|ryP NITDS3ZUSU6JRWK=
HCE-T M3;MO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMU[1NFQh|ryP NF;3d2hUSU6JRWK=
LOXIMVI MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMU[5OFkh|ryP M3z0R3NCVkeHUh?=
ARH-77 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DhSWlEPTB;MD6xO|M4QSEQvF2= M4HMR3NCVkeHUh?=
DOHH-2 NXLqT|hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzJWnpKSzVyPUCuNVc3PzJizszN MoPIV2FPT0WU
COLO-320-HSR MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2r3S2lEPTB;MD6xPFE2PCEQvF2= M4L1XnNCVkeHUh?=
NB6 M2jXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfYS4JyUUN3ME2wMlE5PTZ4IN88US=> MV3TRW5ITVJ?
L-428 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMUi4NVMh|ryP MXPTRW5ITVJ?
SNB75 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3GzcWlEPTB;MD6xPFgzPCEQvF2= NXjVO3dlW0GQR1XS
NCI-H2141 M{PZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXWTWM2OD1yLkG5NFEyKM7:TR?= NF\Y[Y1USU6JRWK=
KARPAS-299 NF65UmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnMdGRbUUN3ME2wMlE6OjRzIN88US=> MmDwV2FPT0WU
LC4-1 MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMUm1NFIh|ryP NGe2TXJUSU6JRWK=
UACC-257 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jq[GlEPTB;MD6xPVk1PyEQvF2= M{HobnNCVkeHUh?=
EVSA-T MlPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzwXo5XUUN3ME2wMlIxOzF{IN88US=> M4\BN3NCVkeHUh?=
JiyoyeP-2003 Mmf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkL2TWM2OD1yLkKwOFc4KM7:TR?= MnXpV2FPT0WU
NCI-H720 Mn65S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DSSWlEPTB;MD6yNFUzPSEQvF2= NVLCUm5LW0GQR1XS
GAK MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTBTWM2OD1yLkKxNVg6KM7:TR?= NYLOXGtlW0GQR1XS
HH MmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDUcJhPUUN3ME2wMlIyPDB3IN88US=> Ml;yV2FPT0WU
NCI-H1436 NF\kT|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMkG0OlQh|ryP NFi4VnpUSU6JRWK=
GR-ST NUTQRVU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rPT2lEPTB;MD6yNVQ5QCEQvF2= M4C0RXNCVkeHUh?=
BC-1 NHSw[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTBwMkK2NVYh|ryP MWXTRW5ITVJ?
SIG-M5 M1L2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPLfVNjUUN3ME2wMlIzPzJ5IN88US=> NWLnNIYxW0GQR1XS
NCI-H345 NUfienlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTBwMkO4NFUh|ryP MWTTRW5ITVJ?
OPM-2 NWi4e2VwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXMTWM2OD1yLkKzPFgzKM7:TR?= MWnTRW5ITVJ?
LB1047-RCC NUjMTGM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPX[3NKSzVyPUCuNlQ1OSEQvF2= M{PLT3NCVkeHUh?=
CTB-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDFNlhVUUN3ME2wMlI1PDl|IN88US=> MnTLV2FPT0WU
A3-KAW Ml;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[3Z5UzUUN3ME2wMlI2OzRzIN88US=> MYnTRW5ITVJ?
SF126 NGPKSGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfrTWM2OD1yLkK1N|g{KM7:TR?= NELsT5dUSU6JRWK=
KARPAS-422 NWLj[oFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;KWWlEPTB;MD6yOVQ{PSEQvF2= M1TJOnNCVkeHUh?=
MEG-01 NFP5cJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMkW2O|Mh|ryP MYPTRW5ITVJ?
NCI-H209 M{n6TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTwTWM2OD1yLkK2N|c1KM7:TR?= MnLKV2FPT0WU
SBC-1 NXT0SI1wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX0XoxxUUN3ME2wMlI3PSEQvF2= MWLTRW5ITVJ?
K5 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMk[5PFQh|ryP NX:5eWZiW0GQR1XS
QIMR-WIL MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrqeHRKSzVyPUCuNlcyPTVizszN NUi5ZVFRW0GQR1XS
NMC-G1 NV;CWmxzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDYb3VKSzVyPUCuNlgzOTdizszN NVzD[FY6W0GQR1XS
IST-MES1 NIi1bXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[wWmZKSzVyPUCuNlkzOzhizszN M{LDbnNCVkeHUh?=
SW684 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwM{CwOFch|ryP NYXkTpBvW0GQR1XS
MV-4-11 NWi5R5pJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LXPGlEPTB;MD6zNFc5QCEQvF2= NFzTT49USU6JRWK=
LAN-6 NI[2N|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PXdmlEPTB;MD6zNVU4OiEQvF2= NG\McYtUSU6JRWK=
RH-1 M1XhZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwM{G4O|Eh|ryP M4rhR3NCVkeHUh?=
CP66-MEL MkPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfDOoJKSzVyPUCuN|E5PzhizszN M4S0WHNCVkeHUh?=
EC-GI-10 MlTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTnTWM2OD1yLkOyPVg4KM7:TR?= M4rIfnNCVkeHUh?=
GDM-1 NGfmO2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2L3UWlEPTB;MD6zN|A2QSEQvF2= M{HBUXNCVkeHUh?=
IST-SL1 MnX4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwM{S5NVQh|ryP M{TRRnNCVkeHUh?=
KMOE-2 M{jtXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL5Z2xKSzVyPUCuN|UyPzVizszN MVTTRW5ITVJ?
OS-RC-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\IXIZKSzVyPUCuN|U2PDRizszN MoraV2FPT0WU
HDLM-2 NVLOUWtQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4GxR2lEPTB;MD6zO|gyPCEQvF2= NV3kWGd3W0GQR1XS
DSH1 M3flRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3wTWM2OD1yLkO4OlMyKM7:TR?= NYDXPYZ{W0GQR1XS
LS-1034 NVrUPWxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfkeVNKSzVyPUCuN|g6PTRizszN NGe1V2xUSU6JRWK=
LB373-MEL-D MlyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e5XWlEPTB;MD6zPVE6PyEQvF2= NE\Id2hUSU6JRWK=
GOTO M3LnPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3teWdKSzVyPUCuOFIyOThizszN M13G[nNCVkeHUh?=
MRK-nu-1 NIjXcotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvxTWM2OD1yLkSyNlA2KM7:TR?= NXfpd5ZxW0GQR1XS
SK-MM-2 M2r1Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PQe2lEPTB;MD60N|Q1OiEQvF2= MonhV2FPT0WU
BOKU Mo\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwNEO3PVIh|ryP NEPwe2FUSU6JRWK=
NOMO-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrFTWM2OD1yLkSzPFYh|ryP MUHTRW5ITVJ?
J-RT3-T3-5 NYr4b2s5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwNES4O|gh|ryP NHPHPWdUSU6JRWK=
COLO-668 NGTVTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwNEW2Olgh|ryP MlToV2FPT0WU
SF539 NIjTRo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4OyRmlEPTB;MD60PFY5PCEQvF2= MoHoV2FPT0WU
LB2518-MEL MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYewRZV6UUN3ME2wMlQ6PzB|IN88US=> MX3TRW5ITVJ?
TE-441-T M2TST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfZZ5g6UUN3ME2wMlUxOTJizszN NVfGN|R4W0GQR1XS
MDA-MB-134-VI MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HEZWlEPTB;MD61NFkzOSEQvF2= MmP4V2FPT0WU
SCC-3 NV;RNm1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP3TWM2OD1yLkWxPFc{KM7:TR?= MmnlV2FPT0WU
KLE NELXfG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwNUKxO|Eh|ryP NGTkO4VUSU6JRWK=
LB2241-RCC NU\LepZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLCTVNKSzVyPUCuOVI2OjVizszN NHPLS3ZUSU6JRWK=
NCI-H1417 NFT1dItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7rdI5KUUN3ME2wMlU{PDN3IN88US=> M4nTUXNCVkeHUh?=
NCI-H2081 NH7LWJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDPTWM2OD1yLkW4OlEyKM7:TR?= NUXmT2s6W0GQR1XS
NCI-H1522 NILWWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwNUmzPFMh|ryP M4TQfHNCVkeHUh?=
NCI-H889 M2TyOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfOcJNKUUN3ME2wMlU6QDR2IN88US=> NFHWOlFUSU6JRWK=
CGTH-W-1 NFXFeHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvwZW1KSzVyPUCuOlA4PTVizszN MmLjV2FPT0WU
EB-3 NHHBUpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH[5SFBKSzVyPUCuOlEyPTNizszN MnHuV2FPT0WU
D-336MG NEDwUpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwNkG3PVEh|ryP NH60[XdUSU6JRWK=
LC-1F M1;5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFO5eZRKSzVyPUCuOlI2QTJizszN NXvZdWhuW0GQR1XS
MHH-NB-11 NHvyVmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHz5RoZKSzVyPUCuOlM5ODFizszN MkDzV2FPT0WU
SK-N-FI NInRTIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zp[2lEPTB;MD62N|kyKM7:TR?= M1nvOXNCVkeHUh?=
NCI-H69 MmrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfHTWM2OD1yLk[0PFc6KM7:TR?= MVzTRW5ITVJ?
SCH NVPheG9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XKVmlEPTB;MD62OlAzOyEQvF2= NEf2fHlUSU6JRWK=
LS-513 NYL0T3pjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwNkeyOVkh|ryP M2jISnNCVkeHUh?=
CP67-MEL NYfYR4tCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\OT3JWUUN3ME2wMlY4PTl4IN88US=> MX;TRW5ITVJ?
GCIY MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwN{CzOlMh|ryP M3f4Z3NCVkeHUh?=
SHP-77 NHXmSXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwN{C3N|Qh|ryP M4KyPHNCVkeHUh?=
EHEB MlrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTLRWVXUUN3ME2wMlcyQDV2IN88US=> M{XqN3NCVkeHUh?=
D-247MG M3jMfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXz2cW9wUUN3ME2wMlc{OjN{IN88US=> NHzIWJRUSU6JRWK=
Raji MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;sdXhJUUN3ME2wMlc1QTh7IN88US=> M4P1TXNCVkeHUh?=
MPP-89 MmTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fSSGlEPTB;MD63OVk4QCEQvF2= MX7TRW5ITVJ?
EKVX NWTGc2tST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnUXI5KSzVyPUCuO|kxPzNizszN MY\TRW5ITVJ?
HCC2218 M1fTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\MVYFTUUN3ME2wMlc6OTNzIN88US=> NEDadVVUSU6JRWK=
KNS-81-FD M1\YVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7PVodKSzVyPUCuPFExOTFizszN M3nKcXNCVkeHUh?=
HCC2157 MoLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fzRmlEPTB;MD64OFk2OSEQvF2= M2T6U3NCVkeHUh?=
BT-474 MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvvXVJ{UUN3ME2wMlg5QDV2IN88US=> NHnlO2pUSU6JRWK=
NCI-H748 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrqfY02UUN3ME2wMlkyOiEQvF2= MYjTRW5ITVJ?
EW-24 MkDvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXG[mQ{UUN3ME2wMlkzODB{IN88US=> NX;QTG9DW0GQR1XS
D-263MG NF\pc4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjZUohKSzVyPUCuPVQ2OTJizszN MnHoV2FPT0WU
OMC-1 Mn;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwOU[zO|Mh|ryP M13nWnNCVkeHUh?=
NCI-H2196 NVqxbVVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rQSGlEPTB;MD65O|c4PyEQvF2= MXfTRW5ITVJ?
HAL-01 M{jvXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwOUm4O|Ih|ryP M3m4RnNCVkeHUh?=
NCI-H2107 NXK1VId6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\F[mlEPTB;MT6wNVg2PCEQvF2= NYXCZ5pLW0GQR1XS
LB996-RCC NX:yc|Q1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrqV5dKSzVyPUGuNFgxPTFizszN NGnVToJUSU6JRWK=
NCI-H1395 NXnoXmVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rZOWlEPTB;MT6xNFY4KM7:TR?= MYLTRW5ITVJ?
CHP-126 MmjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTFwMU[xPVkh|ryP MWfTRW5ITVJ?
NB69 M1zuWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7VWYpKSzVyPUGuNlYyPDhizszN Mn\SV2FPT0WU
CAS-1 MnfJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jRWWlEPTB;MT6zOFI{OSEQvF2= MXjTRW5ITVJ?
JVM-3 NEjWW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTFwNEe4OVUh|ryP Mn3VV2FPT0WU
DMS-153 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTFwNUe2O|Qh|ryP MljIV2FPT0WU
SK-MEL-2 NGP5TZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTFwN{G3PFkh|ryP M1vKU3NCVkeHUh?=
NCI-H1155 NEixeFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwN{O2O|Yh|ryP MlLJV2FPT0WU
NCI-H1092 MnzrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TrfWlEPTB;MT63OlE5OiEQvF2= MVTTRW5ITVJ?
LU-165 M4HFbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzUTm54UUN3ME2xMlg3PDd4IN88US=> MlzDV2FPT0WU
HL-60 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFwOUm5NFgh|ryP MXzTRW5ITVJ?
REH NEG2XmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJwMEC1PFIh|ryP MYXTRW5ITVJ?
JVM-2 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJwME[xN|Uh|ryP MnfmV2FPT0WU
MN-60 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1L5W2lEPTB;Mj6xO|MxQCEQvF2= MofxV2FPT0WU
SCC-15 NG\QXodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjud242UUN3ME2yMlIxOjdizszN NG\1SXRUSU6JRWK=
SNU-C1 M{nBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmL3TWM2OD1{LkKxN|Q{KM7:TR?= MlzuV2FPT0WU
SK-MEL-1 NWezSnZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTJwM{KwOFch|ryP NUniRoRLW0GQR1XS
TGW MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJwM{WwNlch|ryP M1zHW3NCVkeHUh?=
CA46 M2jJRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XpdWlEPTB;Mj63OVk3PyEQvF2= NUfnTpVmW0GQR1XS
NCI-H23 M4mxfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTNTWM2OD1{LkiwO|kyKM7:TR?= NG\0co9USU6JRWK=
MMAC-SF NUnjOnhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TpXmlEPTB;Mj64OlYzQCEQvF2= MUjTRW5ITVJ?
NCI-H2171 Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;NdFB2UUN3ME2zMlA{PDR6IN88US=> MUPTRW5ITVJ?
A704 NHXheJpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO4SpZWUUN3ME2zMlE1OTl2IN88US=> M3XjN3NCVkeHUh?=
DB MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULiW3R{UUN3ME2zMlI2PTd4IN88US=> Mo[3V2FPT0WU
NCI-H719 NETrT3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlm4TWM2OD1|LkOwN|g1KM7:TR?= M3L3XnNCVkeHUh?=
MC-CAR NUHoOYFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\XTWM2OD1|LkW0PFE4KM7:TR?= M{XHR3NCVkeHUh?=
SIMA MkO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\oTWM2OD1|LkW4OFE3KM7:TR?= NYPsb4ZKW0GQR1XS
SW872 NGfHUplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXtTWM2OD1|Lke4NVAyKM7:TR?= Ml65V2FPT0WU
HCC1187 M17oSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTNwN{izNVUh|ryP Mom5V2FPT0WU
EW-13 NEHmN3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLaTWM2OD1|LkizOFE4KM7:TR?= Ml:2V2FPT0WU
NCI-SNU-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPCbHdkUUN3ME20MlIyQTl7IN88US=> NEHYVJNUSU6JRWK=
NCI-H226 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHe1fZVKSzVyPUSuN|M3ODZizszN NXu2T2REW0GQR1XS
RPMI-8866 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvtTWM2OD12LkO2NFI6KM7:TR?= NFrZZ|dUSU6JRWK=
OCI-AML2 MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;j[29KSzVyPUSuOVUzOyEQvF2= NIjUWoZUSU6JRWK=
LU-65 NXnMVXZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HsTmlEPTB;ND65N|A{OyEQvF2= MVTTRW5ITVJ?
SK-N-DZ NHLRS2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTVwNkO0OlUh|ryP M{\WOnNCVkeHUh?=
NB14 NFfqPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3NTWM2OD13Lkm3NVM2KM7:TR?= NUnJOHVHW0GQR1XS
COLO-829 MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTZwM{OzOVkh|ryP NVfkN5NMW0GQR1XS
MHH-CALL-2 M3HmNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPoW3VIUUN3ME22MlUyPTB6IN88US=> NF3zNFRUSU6JRWK=
NCI-H1770 M{KzO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fOWmlEPTB;Nj62OlkxPCEQvF2= NYrYT|lbW0GQR1XS
ECC4 M1vrNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTZwOEKxO|kh|ryP Mn32V2FPT0WU
A498 NITJVppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[1dZppUUN3ME22Mlg4OTl{IN88US=> MmC3V2FPT0WU
DMS-79 NIe5WItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDVdFJtUUN3ME23MlA1PTF{IN88US=> NV;xfmlVW0GQR1XS
P30-OHK NH3HdpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTdwMkG5NFYh|ryP NULOVZBIW0GQR1XS
D-502MG M1zzemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkmxTWM2OD15Lkm4N|Yh|ryP MnG5V2FPT0WU
RCC10RGB NFfGXmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2D6TmlEPTB;OD6wOlI5KM7:TR?= NEX5foxUSU6JRWK=
U-698-M MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfZdJRKSzVyPUiuNlkzOjZizszN MUDTRW5ITVJ?
BB49-HNC Mn6xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPNdHdKSzVyPUmuOFIzPjVizszN MlvqV2FPT0WU
ES1 NIK5fGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTlwNki5OVYh|ryP NUTUTGl{W0GQR1XS
MFM-223 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzvWYpKSzVyPUGwMlk6OjdizszN NFv3SmdUSU6JRWK=
C2BBe1 M376SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfjOmhVUUN3ME2xNU4{PTJ|IN88US=> NUL6doFEW0GQR1XS
EB2 MnrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i2d2lEPTB;MUKuOlg5OSEQvF2= NUf1XJVwW0GQR1XS
C8166 Mlf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PaNWlEPTB;MUOuPFMxOyEQvF2= NHu4cHpUSU6JRWK=
ES3 NILTRXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLldWx2UUN3ME2xN{46QTd5IN88US=> NVHQc2lTW0GQR1XS
NCI-H1650 M4WzOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2GxfWlEPTB;MU[uN|c3PSEQvF2= MUHTRW5ITVJ?
Mo-T NYeyc|lwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFvtXYdKSzVyPUG3MlQxOjlizszN Mmq1V2FPT0WU
NB7 NHPCT|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;NR2lEPTB;MUeuO|Q3PyEQvF2= Mk[zV2FPT0WU
ES7 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHVTYtbUUN3ME2xPU42PTB5IN88US=> MYDTRW5ITVJ?
ES5 NEDjT2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HvWWlEPTB;MkGuO|Y4OSEQvF2= NFL6eI1USU6JRWK=
MSTO-211H Ml[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDvXVdKSzVyPUKxMlg5PThizszN MlW3V2FPT0WU
U-87-MG NFf0PFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTFRodwUUN3ME2yOU4yQTZ4IN88US=> MWXTRW5ITVJ?
THP-1 NGrUdYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzKTWM2OD1{OT63NlAyKM7:TR?= MoDVV2FPT0WU
NB10 M2PuWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\UeWlEPTB;M{CuNlY6PCEQvF2= M1TESXNCVkeHUh?=
NH-12 NEfxW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYKxdo1pUUN3ME2zN{4zODF5IN88US=> NF7ZR3hUSU6JRWK=
COLO-824 M2fJcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPuTWM2OD1|ND6xNFA3KM7:TR?= M37uR3NCVkeHUh?=
SKM-1 Mlv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDXR|ZKSzVyPUO3Mlg1OjJizszN MlzMV2FPT0WU
NCI-H1838 NHnacGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPRZZVjUUN3ME2zPE4{Pzl5IN88US=> MWHTRW5ITVJ?
RL NYPE[pQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTN7LkK0O|ch|ryP MVrTRW5ITVJ?
COLO-800 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTRyLkC3O|Mh|ryP NW\ufJVLW0GQR1XS
KG-1 NIHEbFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3FOIhKSzVyPUSwMlg6PTVizszN NIHkVG9USU6JRWK=
TUR M2nRVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTRzLk[zPVkh|ryP M3SwPHNCVkeHUh?=
LNCaP-Clone-FGC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTRzLkmwNVch|ryP MnfSV2FPT0WU
NCI-H322M M3fU[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXjTWM2OD12Mj61PVg1KM7:TR?= NEXTUY5USU6JRWK=
LNCaP  NV3NdFZbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTlzLkOgcm0> M1iw[VI2PTB3MUe0
C4-2 NIjVPHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\Fc2lEPTB;ODDuUS=> NVu5OIpMOjV3MEWxO|Q>
JURKAT M{HheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofZNlQhcA>? MnfzTWM2OD12MU[uOlYhdk1? NEHNU3czPDVzOUm5OS=>
MOLT-4 M3GxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M375OVI1KGh? NFjpOWJKSzVyPUK4OVMvPSCwTR?= NWPwbFVCOjR3MUm5PVU>
REH MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKxNlQhcA>? MkLsTWM2OD1{OEeuOlghdk1? MoixNlQ2OTl7OUW=
NALM-6 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXxOm03OjRiaB?= NIjX[nhKSzVyPUO0N|MxKG6P NHK3TI0zPDVzOUm5OS=>
RS 4;11 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LkO|I1KGh? NELoTHJKSzVyPUWxPU4xPSCwTR?= M37TbVI1PTF7OUm1
697 M{DOVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\lTFI1KGh? NICybGhKSzVyPUKxNFcvOSCwTR?= NGjK[lQzPDVzOUm5OS=>
SIL-ALL Mm\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml6yNlQhcA>? NV7aZowyUUN3ME2xPVkvPzdibl2= MkLTNlQ2OTl7OUW=
CEM NVXoVoZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnsUXF5OjRiaB?= NHG3XItKSzVyPUWyMlE5KG6P NVXVOXFqOjR3MUm5PVU>
P12 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW[yOEBp MV7JR|UxRTN7LkK3JI5O NWLYbnNlOjR3MUm5PVU>
NALM-16 MonvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Hjb|I1KGh? MWHJR|UxRTl4LkK4JI5O MnvMNlQ2OTl7OUW=
JURKAT MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrKR3o1QCCq MkDhTWM2OD1zND64OEBvVQ>? NWPMTG82OjR3MUm5PVU>
MOLT-4 MkH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPW[VNPPDhiaB?= MXjJR|UxRTJ4Lk[gcm0> Mm\hNlQ2OTl7OUW=
REH NUnLPGZvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXi0PEBp M1SxNWlEPTB;NESuO|Ehdk1? NFH0TW4zPDVzOUm5OS=>
NALM-6 Mm\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH3WWo1QCCq Mo[0TWM2OD1{Mz6yOkBvVQ>? M3fFV|I1PTF7OUm1
RS 4;11 M{juRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVT1ZYRNPDhiaB?= M3zXfWlEPTB;MU[0MlI5KG6P NHX2c|EzPDVzOUm5OS=>
697 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK4N2M1QCCq MXXJR|UxRTNyNT6zJI5O NH7vXZYzPDVzOUm5OS=>
SIL-ALL NY\TNGhlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVi0PEBp NWWyXmlCUUN3ME23OE43OiCwTR?= M1S0O|I1PTF7OUm1
CEM MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn4OFghcA>? NWTOXpM5UUN3ME2yOE42PSCwTR?= M3z4[|I1PTF7OUm1
P12 NVLMRol6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LVXVQ5KGh? M4nqeGlEPTB;MUiuOFYhdk1? MUSyOFUyQTl7NR?=
NALM-16 NETj[YtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LFXVQ5KGh? M4PufGlEPTB;NkOuNlQhdk1? M4nzNlI1PTF7OUm1
JURKAT NFL4b5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\xO|IhcA>? NEfK[mZKSzVyPUOuOlUhdk1? M{S4VFI1PTF7OUm1
MOLT-4 NI\WdXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlruO|IhcA>? MVzJR|UxRTdwM{mgcm0> NXvyOmhuOjR3MUm5PVU>
REH MlnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUW3NkBp MkH4TWM2OD1zNj6wNUBvVQ>? M3rRUlI1PTF7OUm1
NALM-6 NWTuTpVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HkOFczKGh? MlH5TWM2OD1zLke4JI5O NWG2[ZFTOjR3MUm5PVU>
RS 4;11 NGTYO5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV[3NkBp MUPJR|UxRTRwM{igcm0> NH:z[lQzPDVzOUm5OS=>
697 NUewVHVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIr4PIU4OiCq MXLJR|UxRTd2LkK4JI5O NFfiZZozPDVzOUm5OS=>
SIL-ALL M1K3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DWTFczKGh? Ml22TWM2OD15LkKgcm0> NUmwVlN{OjR3MUm5PVU>
CEM NHnIdG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHK5U4c4OiCq NHnTOoZKSzVyPUWuOFIhdk1? MlHLNlQ2OTl7OUW=
P12 NFvL[2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW[3NkBp NIT1T4RKSzVyPU[uN|chdk1? M37EbVI1PTF7OUm1
NALM-16 M{LqW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYj1VHBlPzJiaB?= Ml\MTWM2OD15Nz63N{BvVQ>? M3XMZVI1PTF7OUm1
Y79 MoTWRZBweHSxc3nzJGF{e2G7 NHzLV4EyNTVyIH7N NYnaXnY{OTJxMkSgbC=> MnP5SG1UVw>? MUnpcoR2[2WmIHHwc5B1d3OrczD3bIlkcCClYX6gZoUh\W6qYX7j[YQh[nliSGS= NGPO[40zPDN4Nk[2OS=>
WER-Rb-1 NVLIRo1ySXCxcITvd4l{KEG|c3H5 NVfDc2hoOS13MDDuUS=> MUixNk8zPCCq Mk\QSG1UVw>? NVn2dJZDcW6mdXPl[EBieG:ydH;zbZMhf2irY3igZ4FvKGKnIHXubIFv[2WmIHL5JGhV MnmwNlQ{PjZ4NkW=
G7 NGXvOZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfmTWM2OD1|LkOgcm0> MYqyOFIxPDd|Mx?=
G166 M1SwdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HSUWlEPTB;Nz6wJI5O M3XUVlI1OjB2N{Oz
CB660 MojVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n5Z2lEPTB;Nj60JI5O MYOyOFIxPDd|Mx?=
CB1117 NGnueHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF3Lk[gcm0> MkPXNlQzODR5M{O=
KB-3-1 NWq5PW9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTVWlJZUUN3ME2xMlQ5KMLzIECuOVMhdk1? NFLmPYMzOzl4MkS0OS=>
KB-8-5-11 NX22cpNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXO1N5pOUUN3ME21MlAyKMLzIEKuNFEhdk1? MV6yN|k3OjR2NR?=
KB-C-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF4Lke2JOKyKDRwNUGgcm0> Mm\VNlM6PjJ2NEW=
KB-V-1 NETBR4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJ6MT6yOEDDuSB|MT61O{BvVQ>? NI\3NnMzOzl4MkS0OS=>
OVCAR-8 NHK3NIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljaTWM2OD15LkG5JOKyKDNwNkCgcm0> M3jHdFI{QTZ{NES1
NCI-ADR-RES MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnTTXlGUUN3ME2xNlc{NjNyINMxJFE6OS5{MDDuUS=> MnfxNlM6PjJ2NEW=
MCF7 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDCbWlKSzVyPUWuNVEhyrFiMT60O{BvVQ>? M3niSFI{QTZ{NES1
MCF7-FLV1000 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrKNXVmUUN3ME2zPVMvOThiwsGgO|QvQDNibl2= MkTtNlM6PjJ2NEW=
S1 NUHvR3BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTJ2LkOwJOKyKDRwN{Wgcm0> NULx[ll3OjN7NkK0OFU>
S1-M1-80 Mo[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHDSnhKSzVyPUK2NU4xPiEEsTC0PE4zPSCwTR?= NVfyRpBMOjN7NkK0OFU>
CORL-23/P MnOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXf2O|RuUUN3ME20MlM5KMLzIEGuNlUhdk1? M4PTOVI{QTZ{NES1
CORL-23/R Mn;RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTVwMU[gxtEhOS56MzDuUS=> NHzCTmkzOzl4MkS0OS=>
NIH3T3 NHPQe25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy0dpFKSzVyPUSwMlYxKMLzIESuPVchdk1? M4LQOFI{QTZ{NES1
NIH3T3-G185 NIjkbpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLDTWM2OD1{NEGzMlQxKMLzIESyN{43PiCwTR?= MUKyN|k3OjR2NR?=
pcDNA-HEK293 M4izU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX5TWM2OD1{Lke1JOKyKDBwNkegcm0> NYfST4R2OjN7NkK0OFU>
MDR19-HEK293 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjLTWM2OD16NT61NEDDuSBzMz62O{BvVQ>? MoK1NlM6PjJ2NEW=
R482-HEK293 Mo\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP5OVVtUUN3ME2yOU46PyEEsTC0Mlk2KG6P NF7zNZMzOzl4MkS0OS=>
MRP1-HEK293 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTJwOUmgxtEhOS52OTDuUS=> MorHNlM6PjJ2NEW=
SF188 M{TlNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVmxNE0yODBibl2= MWWyOE06PiCq NYXxNWluTE2VTx?= MWrpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWVvIHHu[EBkd26lZX70doF1cW:wLTDk[ZBm\GWwdDDtZY5v\XJ? M1rWcFI{QDh5NkS1
T98G NVXXWXNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TBV|ExNTFyMDDuUS=> MV2yOE06PiCq NXK5N3VsTE2VTx?= NGPySWlqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDjc45k\W62cnH0bY9vNSCmZYDl[IVvfCCvYX7u[ZI> M{fHTVI{QDh5NkS1
DU145 M2jkb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PK[WROW09? NFjYXYZKSzVy4pk8OlAhdk1? M{f0dlI{QDh2NEK4
LNCaP  NYfrZ45iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;nSG1UVw>? Mn25TWM2OOLKvEe1JI5O M4Wy[VI{QDh2NEK4
PC3 M4fIPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7VSG1UVw>? NUTTR3U6UUN3MPMIwFE4PSCwTR?= MV:yN|g5PDR{OB?=
RT4 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HDfmlEPTB;MkeuNlEhdk1? Mni5NlM4QTJ4M{m=
5637 NYjBdWw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTR3LkS3JI5O MUGyN|c6OjZ|OR?=
T24 NIK5UmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTd7LkGyJI5O M4rCVFI{Pzl{NkO5
MCF7  NFGxUJBHfW6ldHnvckBCe3OjeR?= NUm0SWRCOTByIH7N NVfsSVZ4OSCq M1vvSGROW09? M1TtTJJm\HWlZYOgeIhmKGmwZIXjeIlwdiCxZtMgS5Jm[jFuwrDT[4syNMLiUIOyMOKhW2W{cHnuZVMtKGGwZNMgW4l{eDJ? MXmyN|c4ODJ2NB?=
KB-V1  Mn7wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jHPGlEPTB;Mz65NkDPxE1? M3Lne|I{PTl|MUm2
Hec50co M3fScGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTVibl2= MX6yN|E1PjZ6Nx?=
MDA-MB-468 NIjiU5pCeG:ydH;zbZMhSXO|YYm= NHXLeYkyNzVxMUCgcm0> MmHONlQwPDhxN{KgbC=> MWfEUXNQ NGXtTI5qdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MYiyN|E1PDJ7NB?=
MCF10A M{XBUGFxd3C2b4Ppd{BCe3OjeR?= NGjDN4oyNzVxMUCgcm0> MnHDNlQwPDhxN{KgbC=> NWC5eVl{TE2VTx?= NFLlXINqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M{jLbFI{OTR2Mkm0
Huh-7 Mmq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfPeIUyNzFyL{GwNE8yODByIH7N MXi0PEBp NFfxc|Bl\WO{ZXHz[ZMhfGinIHPlcIwhfmmjYnnsbZR6KGSxc3Wt[IVx\W6mZX70cJk> NVzm[Y5mOjJ5NEW1PFc>
Daoy  MkK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X6dVEvQDd3LUK0NEBvVQ>? MlfXO|IhcA>? MVfEUXNQ M3\icWlEPTB;NTDuUS=> NH\nNVQzOjN7MEK3PS=>
ONS-76 NYLHcHkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnP0NU45PzVvMkSwJI5O NIDFXYY4OiCq NVjQfYhPTE2VTx?= NWDTPJJnUUN3ME23MlUhdk1? NVf5[3hOOjJ|OUCyO|k>
SUM 149 MoXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnJZpMxNTFyMDDuUS=> NGLieYQ4OiCq Mmr4bY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy M4nzT|IzOzB7OUO5
MDA-MB-231 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvYNE0yODBibl2= MVe3NkBp NVjqXVVJcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz MWKyNlMxQTl|OR?=
HR5 M37XfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV2wMVExOCCwTR?= MXe3NkBp Mn24bY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy NX;kV|dZOjJ|MEm5N|k>
BT-474-M1 NXnyS3VUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDEdGg5OC1zMECgcm0> NWnaV|dtPzJiaB?= NHnlW5BqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI> MWOyNlMxQTl|OR?=
AU565 NIS5PWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYmwMVExOCCwTR?= NULpVW1ZPzJiaB?= M1TDUolvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> MYWyNlMxQTl|OR?=
T47D NYHTTJN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vIXVAuOTByIH7N NFj1OJM4OiCq MlXHbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy NUfkUYxtOjJ|MEm5N|k>
MCF7 NG[wOZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrodXYxNTFyMDDuUS=> MXi3NkBp NUjqRlZIcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz NE[xWmIzOjNyOUmzPS=>
HCT116p53(+/+) NUi2[|hJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPmfJNnOTBvMUCwNEBvVQ>? NYPUc2s{OjRxNEigbC=> NWTubVNScW6qaXLpeJMh[2WubDDwdo9tcW[ncnH0bY9vKGOxbYDs[ZRmdHliYYSgNlUhdk1? MViyNlI3OjF5MR?=
HCT116p53(-/-) MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LRTlExNTFyMECgcm0> NFTLVXYzPC92ODDo MmfZbY5pcWKrdIOgZ4VtdCCycn;sbYZmemG2aX;uJINwdXCuZYTlcJkh[XRiMkWgcm0> M33KclIzOjZ{MUex
HeLa  M3SzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvFU41LOTBvMUCwJI5O NYjab2hVPDhiaB?= M{jVSGROW09? MoW2TWM2OD13Mj65JI5O NGi4[pQzOjB6MEKzOS=>
HeLa  MlrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fFXVExNTFyMDDuUS=> NHvWXI84OiCq M4jpXWROW09? NF3LR5FKSzVyPUWwMlUhdk1? M1nmelIzODhyMkO1
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U937 Ml;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjwNU8yOC9zMECgcm0> M1ewUFczKGh? NX7hNJJFTE2VTx?= M3O5dYlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MV[xPVQ2QDN3OB?=
CAL62 NWr6ZYU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fUdFAvOS1zMECgcm0> MoXDO|IhcA>? NGnp[4hFVVOR Ml6wSWM2OD1zLkSgcm0> NXTLZpVnOTl{MkO1OVM>
OCUT-1 MlS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnSNE4yNTFyMDDuUS=> NUXGcZFXPzJiaB?= M2HnN2ROW09? M33BVmVEPTB;Mj6zJI5O NHnFe|MyQTJ{M{W1Ny=>
8505C NFzaSIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37uUlAvOS1zMECgcm0> M13sOlczKGh? NXHUOZNwTE2VTx?= NHPFfnRGSzVyPUOuNkBvVQ>? Ml:0NVkzOjN3NUO=
ACT-1 M2\4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUmwbG9oOC5zLUGwNEBvVQ>? M{\VTVczKGh? NIjiNXpFVVOR NYr2e5RGTUN3ME21MlQhdk1? NUXTbJVPOTl{MkO1OVM>
SW1736 NEXGPGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\1XppbOC5zLUGwNEBvVQ>? NIiyNow4OiCq NWfJWZJzTE2VTx?= NInaSYRGSzVyPUWuOkBvVQ>? MWKxPVIzOzV3Mx?=

... Click to View More Cell Line Experimental Data

体内研究 BI 2536静脉注射给药多种移植瘤模型,每周一次或两次,效果都很好,通过使细胞周期停滞而抑制细胞增殖,随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤,每周一次或两次,显著抑制肿瘤生长,T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型,也显著抑制肿瘤生长,T/C分别为5% 和14%。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验: [1]
+ 展开

体外Plk1激酶实验:

重组人Plk1 (1-603残基) 作为氮端,携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析,使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时,使用 20 ng 重组激酶,及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP)中30oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上,使用1% TCA冲洗实验板,然后利用放射性进行测量。绘制剂量反应曲线,而计算IC50值。
细胞实验:[1]
+ 展开
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等
  • Concentrations: 溶于DMSO, 终浓度为~1 μM
  • Incubation Time: 24,和72小时
  • Method: 使用不同浓度BI 2536处理细胞24和72小时。 在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量,细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟,然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。
    (Only for Reference)
动物实验:[1]
+ 展开
  • Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠
  • Formulation: 在盐酸(0.1 N)中配制,然后在0.9% NaCl中稀释。
  • Dosages: ~50 mg/kg
  • Administration: 静脉注射,每周一到两次
    (Only for Reference)

溶解度 (25°C)

体外 Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
30% PEG 400+0.5% Tween 80+5% Propylene glycol
15mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 521.66
化学式

C28H39N7O3

CAS号 755038-02-9
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • 回答:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

相关PLK产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID