BI 2536

目录号:S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI 2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM,比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。

规格 价格 库存 购买数量  
RMB 1978.87 现货
RMB 981.57 现货
RMB 1704.35 现货
RMB 5492.59 现货
RMB 8160.83 现货
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客户购买Selleck的此次产品后发表的文献55篇:

客户使用该产品的13个实验数据:

  • (C) HeLa cells were treated with inhibitors of Aurora B (hesperadin), Aurora A (Aurora A inhibitor I), CDK1 (roscovitine), or PLK1 (BI2536) for 2 hours before immunostaining for tubulin and phosphorylated RV[S/T]F (p-RV[S/T]F). Nuclei are indicated with DAPI. Control cells were not treated with any inhibitor. More than 50 cells were imaged for each condition in three independent experiments. Scale bar, 20 μm.

    Science, 2018, 11(530), doi: 10.1126/scisignal.aai8669. BI 2536 purchased from Selleck.

    Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

  • (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

    (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

    Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like cells after treatment with BI 2536 for 24 and 48 hours, respectively.

    Oncotarget, 2017, 8(23):37633-37645. BI 2536 purchased from Selleck.

  • Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

  • Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

产品安全说明书

PLK抑制剂选择性比较

生物活性

产品描述 BI 2536是一种有效的Plk1抑制剂,无细胞试验中IC50为0.83 nM,比作用于Plk2和Plk3选择性分别高4和11倍。Phase 2。
特性 BI 2536是第一个有效的Plk1选择性抑制剂,抑制 Plk1的标记。
靶点
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
体外研究

除了Plk1, BI 2536也抑制 Plk2 和Plk3活性,只是抑制程度低点,IC50分别为3.5 nM和9.0 nM。BI 2536比一组63种其他蛋白激酶(IC50>10 μM)选择性高1000多倍。BI 2536 按10 nM 到 100 nM剂量作用于HeLa细胞,抑制有丝分裂中心体中γ-微管蛋白招募和Apc6 磷酸化,抑制染色体臂中释放黏结蛋白, 诱导产生单极主轴,及一些依赖Plk1的其他有丝分裂过程。与作用于Plk1 RNAi效果相一致, BI 2536处理HeLa细胞,使细胞周期停在G2/M期, 随后DNA分解及凋亡,且累积断裂的PARP p85片段,这种作用存在浓度依赖性。BI 2536抑制一组32种人肿瘤细胞系生长,EC50为2-25 nM,抑制指数生长的hTERT-RPE1,人脐静脉内皮细胞 (HUVECs),和正常大鼠肾脏(NRK) 细胞的增殖,EC50为12-31 nM。[1] BI 2536 抑制Plk1,降低甲状腺未分化癌(ATC)细胞如 CAL62, OCUT-1, SW1736, 8505C,和 ACT-1 的生长的生长和活力,EC50为1.4-5.6 nM。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDuTWM2OD1yLkCwO|c3KM7:TR?= NX;pXJdSW0GQR1XS
ACN MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\hTWlEPTB;MD6wNFg1OyEQvF2= M3rUN3NCVkeHUh?=
TE-8 NXS0VYI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3m5S2lEPTB;MD6wNFk1OSEQvF2= MoTRV2FPT0WU
LC-2-ad NY\DfHd7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfv[plKSzVyPUCuNFExQTNizszN M1XjTnNCVkeHUh?=
ALL-PO NH;sSFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fTW2lEPTB;MD6wNVMh|ryP NIXTeWtUSU6JRWK=
EW-16 M4TrN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEGzN|Yh|ryP MkjhV2FPT0WU
KM12 NE\sNmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\PNXNZUUN3ME2wMlAyOzR6IN88US=> NGe5SYJUSU6JRWK=
GI-1 NYjWS3RIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrlVVVKSzVyPUCuNFE{QDNizszN M1nCc3NCVkeHUh?=
LS-411N NUTCS5JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEG0NFch|ryP MV3TRW5ITVJ?
ES8 NEfKWW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF2yRYxKSzVyPUCuNFE1QTRizszN MoTtV2FPT0WU
SNU-C2B NV\tWmRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLpW3ZKSzVyPUCuNFE2OjZizszN NVzITFRQW0GQR1XS
CESS M3HCSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTvWmZOUUN3ME2wMlAyPjB{IN88US=> M2X6SHNCVkeHUh?=
697 Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrxc5hwUUN3ME2wMlAyPjZ6IN88US=> MofRV2FPT0WU
NCI-H1963 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml21TWM2OD1yLkCxOlc{KM7:TR?= MonOV2FPT0WU
IA-LM MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\ISlNKSzVyPUCuNFE3QDhizszN NEDlbphUSU6JRWK=
SW954 M4C3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYntfpRZUUN3ME2wMlAyPzB3IN88US=> NGW5SnNUSU6JRWK=
RL95-2 MoC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEG3N|gh|ryP NUDFO4NCW0GQR1XS
LXF-289 NHfybHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXOTWM2OD1yLkCxO|ch|ryP M3q4WnNCVkeHUh?=
OCUB-M M1XGdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTBwMEG4NlYh|ryP NGnKRoRUSU6JRWK=
RKO NH;sO3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HFZ2lEPTB;MD6wNVk5PyEQvF2= MVnTRW5ITVJ?
LOUCY MmXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPkWGNzUUN3ME2wMlAzODVizszN MVnTRW5ITVJ?
NOS-1 NFHiRlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWS1cldCUUN3ME2wMlAzODl|IN88US=> MYLTRW5ITVJ?
A4-Fuk NW\UU3Q2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEKyNVgh|ryP MnvPV2FPT0WU
A388 M1zHdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;oNGlEPTB;MD6wNlIzPyEQvF2= MUfTRW5ITVJ?
TE-9 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnVOoNlUUN3ME2wMlAzOjZzIN88US=> NVLNXZpvW0GQR1XS
KURAMOCHI NWXnZmJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HZd2lEPTB;MD6wNlI5PSEQvF2= MYPTRW5ITVJ?
KALS-1 NW\sTIpXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEKzN|gh|ryP MYrTRW5ITVJ?
HOP-62 M13oXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEK0NkDPxE1? MYHTRW5ITVJ?
RPMI-8402 MmPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HsfGlEPTB;MD6wNlUxQCEQvF2= MmfVV2FPT0WU
TE-1 NUnOUFl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwMEK1NVIh|ryP NES5[3dUSU6JRWK=
CCRF-CEM MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rpWGlEPTB;MD6wNlU1OyEQvF2= MnOwV2FPT0WU
HUTU-80 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPlTWM2OD1yLkCyOlI1KM7:TR?= Mkf2V2FPT0WU
NCI-H1648 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD4NWR1UUN3ME2wMlAzPjR5IN88US=> NWOxcZYxW0GQR1XS
HCE-4 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33rT2lEPTB;MD6wNlY5OiEQvF2= MXHTRW5ITVJ?
ETK-1 MoToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEK3N|Yh|ryP MkW4V2FPT0WU
TE-15 NVHqS5EzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\ZTWM2OD1yLkCyO|M5KM7:TR?= M4DROXNCVkeHUh?=
BE-13 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjGTWM2OD1yLkCyO|Qh|ryP MkfqV2FPT0WU
KE-37 NYDYZXk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33tNmlEPTB;MD6wNlc1OSEQvF2= NXXxUplqW0GQR1XS
NCI-H1355 M1voeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnZendPUUN3ME2wMlAzPzh|IN88US=> MYLTRW5ITVJ?
TE-11 MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDqZ|FvUUN3ME2wMlAzQDB7IN88US=> NUP5cZN3W0GQR1XS
BL-70 MlTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjjTWM2OD1yLkCyPFU4KM7:TR?= MXfTRW5ITVJ?
ES6 NGrqbnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMEK4PFEh|ryP MXXTRW5ITVJ?
GT3TKB NU\1boNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fmeWlEPTB;MD6wNlk2OyEQvF2= NGPZ[ItUSU6JRWK=
LB647-SCLC MnfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMEOxPVUh|ryP MkTyV2FPT0WU
NB13 M4nrZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEOzNVYh|ryP NIHoPIdUSU6JRWK=
ST486 M1rheGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTUN2NKSzVyPUCuNFM{OzdizszN M37aZ3NCVkeHUh?=
NCI-H82 M{jQSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XVeWlEPTB;MD6wN|M1OyEQvF2= NYi2ZmtVW0GQR1XS
NTERA-S-cl-D1 M{[0XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwMEOzPVkh|ryP MlrGV2FPT0WU
ES4 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PhRWlEPTB;MD6wN|Q3OyEQvF2= MYfTRW5ITVJ?
SK-NEP-1 NVfxXIhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mny5TWM2OD1yLkCzOFk6KM7:TR?= Mo\FV2FPT0WU
Becker NVjsUnIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTIZ5dKSzVyPUCuNFM2PTVizszN NUHUXW1pW0GQR1XS
A101D NGL2dVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMEO3OFgh|ryP M{[3[nNCVkeHUh?=
SK-UT-1 MoHyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETySopKSzVyPUCuNFM4PzRizszN M2nxdXNCVkeHUh?=
SW982 Mmf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHWTWM2OD1yLkCzO|kh|ryP NFPOdI1USU6JRWK=
TE-10 MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TkNWlEPTB;MD6wOFA1PiEQvF2= NGnBc3RUSU6JRWK=
OVCAR-4 NYjQbG9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHCTWM2OD1yLkC0NFU6KM7:TR?= NWLnTlZ4W0GQR1XS
KP-N-YS NX3kSXBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;LTWM2OD1yLkC0NFg2KM7:TR?= Mn;YV2FPT0WU
BL-41 NVm2VlhGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHEb2FOUUN3ME2wMlA1OTJ3IN88US=> NHjVcFZUSU6JRWK=
MZ1-PC NWrvVZpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PFWWlEPTB;MD6wOFEzPyEQvF2= NGPQSGhUSU6JRWK=
PF-382 MmP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:xTWM2OD1yLkC0NVk5KM7:TR?= NH\QdJBUSU6JRWK=
MOLT-13 NXHlSFU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\Ib2pKSzVyPUCuNFQzOzhizszN MmrxV2FPT0WU
HCC1599 NID3[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli4TWM2OD1yLkC0NlU5KM7:TR?= MV7TRW5ITVJ?
IST-MEL1 MoLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXHT2tEUUN3ME2wMlA1PDR{IN88US=> M1\PdXNCVkeHUh?=
LU-139 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnWTWM2OD1yLkC0OFQzKM7:TR?= M1uyUHNCVkeHUh?=
MS-1 NHK5fXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7pZlhKSzVyPUCuNFQ4ODFizszN M{T4bHNCVkeHUh?=
MFH-ino Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvPTWM2OD1yLkC1NFA{KM7:TR?= MnLVV2FPT0WU
IMR-5 M4jPUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDRTWM2OD1yLkC1NFIyKM7:TR?= NXzBdG42W0GQR1XS
TE-5 MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojuTWM2OD1yLkC1NFY{KM7:TR?= MmThV2FPT0WU
DJM-1 NGrjVlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\wVJR4UUN3ME2wMlA2OTR{IN88US=> NYDDVZBuW0GQR1XS
NB17 NE\P[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z6XmlEPTB;MD6wOVIxPyEQvF2= M3LycnNCVkeHUh?=
KARPAS-45 NEf2endIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfXTWM2OD1yLkC1N|U5KM7:TR?= MVXTRW5ITVJ?
TGBC1TKB Mny2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37m[WlEPTB;MD6wOVQxPSEQvF2= NUL5dFZ{W0GQR1XS
ML-2 NGH3e|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvR[o5RUUN3ME2wMlA2PDF2IN88US=> NX3WV3N6W0GQR1XS
no-10 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHn1WIZKSzVyPUCuNFU1PzRizszN NWXYOWppW0GQR1XS
CTV-1 NUm4Wm86T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonITWM2OD1yLkC1OVAzKM7:TR?= MoPGV2FPT0WU
SJSA-1 MlTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXDR5lnUUN3ME2wMlA2PTJizszN MWTTRW5ITVJ?
HC-1 M1XXcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF33UZBKSzVyPUCuNFU2QTdizszN NV\4WG1UW0GQR1XS
TE-12 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVGzeHZJUUN3ME2wMlA2PjF|IN88US=> M1;idXNCVkeHUh?=
KY821 NI\GRZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXaRYVuUUN3ME2wMlA2PjN{IN88US=> NX[0VXdVW0GQR1XS
TALL-1 M{W4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTBwMEW3NFgh|ryP M2fZc3NCVkeHUh?=
DEL NIXCRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXPTWM2OD1yLkC1O|A6KM7:TR?= MVzTRW5ITVJ?
TE-6 MlLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\CVWlEPTB;MD6wOVczOiEQvF2= M3XFTnNCVkeHUh?=
SK-LMS-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWja[3cyUUN3ME2wMlA2QDB3IN88US=> Mn21V2FPT0WU
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NCI-H524 NV\LSWdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\YUIlHUUN3ME2wMlEyOjd2IN88US=> NEnOeXJUSU6JRWK=
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HH NH\CRYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\EUm1tUUN3ME2wMlIyPDB3IN88US=> M3PONHNCVkeHUh?=
NCI-H1436 NHXXOWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TwVWlEPTB;MD6yNVQ3PCEQvF2= NIe1OFFUSU6JRWK=
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KARPAS-422 M2L4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PFXWlEPTB;MD6yOVQ{PSEQvF2= M2nFPXNCVkeHUh?=
MEG-01 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwMkW2O|Mh|ryP M3;1VXNCVkeHUh?=
NCI-H209 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMk[zO|Qh|ryP MljMV2FPT0WU
SBC-1 MlfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXxeIlKSzVyPUCuNlY2KM7:TR?= NGXMeI5USU6JRWK=
K5 NXLkc|JmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzpU3dHUUN3ME2wMlI3QTh2IN88US=> NH64dplUSU6JRWK=
QIMR-WIL NXfGco9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDYO|hKSzVyPUCuNlcyPTVizszN M4i3[HNCVkeHUh?=
NMC-G1 M{TvSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPSe3JKSzVyPUCuNlgzOTdizszN M4rW[3NCVkeHUh?=
IST-MES1 NWHTWXY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrkZlFKSzVyPUCuNlkzOzhizszN M1i4fHNCVkeHUh?=
SW684 MnX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXOzOJd{UUN3ME2wMlMxODR5IN88US=> NH;tdGxUSU6JRWK=
MV-4-11 MlL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfiSpNKSzVyPUCuN|A4QDhizszN MVPTRW5ITVJ?
LAN-6 M17KRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\QWIpKSzVyPUCuN|E2PzJizszN NW\4ZYx1W0GQR1XS
RH-1 MkOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDhTWM2OD1yLkOxPFcyKM7:TR?= NX\vR45zW0GQR1XS
CP66-MEL NVfMXJA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvlTWM2OD1yLkOxPFc5KM7:TR?= MoH6V2FPT0WU
EC-GI-10 M{TRW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zoRmlEPTB;MD6zNlk5PyEQvF2= NHj1TpZUSU6JRWK=
GDM-1 Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwM{OwOVkh|ryP M4i3VnNCVkeHUh?=
IST-SL1 NUjNcnFLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTBwM{S5NVQh|ryP M1\xW3NCVkeHUh?=
KMOE-2 NIn1enhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGj2c2dKSzVyPUCuN|UyPzVizszN M1PBS3NCVkeHUh?=
OS-RC-2 NEnsfpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGzVmpZUUN3ME2wMlM2PTR2IN88US=> M1vFO3NCVkeHUh?=
HDLM-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TLNmlEPTB;MD6zO|gyPCEQvF2= Mn7NV2FPT0WU
DSH1 NWPYXoRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\X[GlEPTB;MD6zPFY{OSEQvF2= MW\TRW5ITVJ?
LS-1034 MkPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\vUVZKSzVyPUCuN|g6PTRizszN M1nK[3NCVkeHUh?=
LB373-MEL-D M3\VcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvwV3JKSzVyPUCuN|kyQTdizszN NIDWNo1USU6JRWK=
GOTO NUHxXG03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwNEKxNVgh|ryP MkT0V2FPT0WU
MRK-nu-1 Moi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwNEKyNFUh|ryP NIHNNWFUSU6JRWK=
SK-MM-2 NIq3N2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHWTWM2OD1yLkSzOFQzKM7:TR?= MmDUV2FPT0WU
BOKU MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\mR2pLUUN3ME2wMlQ{Pzl{IN88US=> M{D4[HNCVkeHUh?=
NOMO-1 NHzaeHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoexTWM2OD1yLkSzPFYh|ryP M{\hPHNCVkeHUh?=
J-RT3-T3-5 MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWq4[pV7UUN3ME2wMlQ1QDd6IN88US=> NI\EVGZUSU6JRWK=
COLO-668 NGPZVJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFv6VlRKSzVyPUCuOFU3PjhizszN M2fsdHNCVkeHUh?=
SF539 M{nR[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHmTWM2OD1yLkS4Olg1KM7:TR?= NIPTXVJUSU6JRWK=
LB2518-MEL MmDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf2[IQzUUN3ME2wMlQ6PzB|IN88US=> MWHTRW5ITVJ?
TE-441-T NYHPZ|dMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwNUCxNkDPxE1? Mnz5V2FPT0WU
MDA-MB-134-VI NIrScINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3kT5VKSzVyPUCuOVA6OjFizszN MVPTRW5ITVJ?
SCC-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LqNmlEPTB;MD61NVg4OyEQvF2= MUDTRW5ITVJ?
KLE MkXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwNUKxO|Eh|ryP NUXQUWtMW0GQR1XS
LB2241-RCC NXfLNVJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzvTWM2OD1yLkWyOVI2KM7:TR?= M2jw[XNCVkeHUh?=
NCI-H1417 NWi3cZo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrJcFJKSzVyPUCuOVM1OzVizszN NX\4e|lrW0GQR1XS
NCI-H2081 NHKzSVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;Ye|BlUUN3ME2wMlU5PjFzIN88US=> NWjNcJJvW0GQR1XS
NCI-H1522 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zTTGlEPTB;MD61PVM5OyEQvF2= NF;vblNUSU6JRWK=
NCI-H889 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n4SGlEPTB;MD61PVg1PCEQvF2= MojjV2FPT0WU
CGTH-W-1 Mo\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP1TWM2OD1yLk[wO|U2KM7:TR?= MUjTRW5ITVJ?
EB-3 M3nFcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlGzTWM2OD1yLk[xNVU{KM7:TR?= MUjTRW5ITVJ?
D-336MG NILmPHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmm2TWM2OD1yLk[xO|kyKM7:TR?= M3q4c3NCVkeHUh?=
LC-1F MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIDKc4NKSzVyPUCuOlI2QTJizszN NGDqdIdUSU6JRWK=
MHH-NB-11 NWCzeVZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTCWmFSUUN3ME2wMlY{QDBzIN88US=> M3nKb3NCVkeHUh?=
SK-N-FI NFzpXFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwNkO5NUDPxE1? Mn74V2FPT0WU
NCI-H69 MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vTcWlEPTB;MD62OFg4QSEQvF2= Mk\mV2FPT0WU
SCH NE\6TmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPMSWxKSzVyPUCuOlYxOjNizszN NVHlcGcyW0GQR1XS
LS-513 NG\XUZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYe2dZBMUUN3ME2wMlY4OjV7IN88US=> MVzTRW5ITVJ?
CP67-MEL M3nFXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofUTWM2OD1yLk[3OVk3KM7:TR?= M2XhdHNCVkeHUh?=
GCIY NX[weo9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mom3TWM2OD1yLkewN|Y{KM7:TR?= NWCxPIhbW0GQR1XS
SHP-77 M1Pu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVX2fmFNUUN3ME2wMlcxPzN2IN88US=> M4rpTnNCVkeHUh?=
EHEB M2PoXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fpUmlEPTB;MD63NVg2PCEQvF2= MUDTRW5ITVJ?
D-247MG NYPCO5FmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\oNZd2UUN3ME2wMlc{OjN{IN88US=> NEnMXJNUSU6JRWK=
Raji MoX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq2eYUxUUN3ME2wMlc1QTh7IN88US=> NFvHSFZUSU6JRWK=
MPP-89 NVH3cmF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HUXGlEPTB;MD63OVk4QCEQvF2= MX3TRW5ITVJ?
EKVX M2THV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrrWVVtUUN3ME2wMlc6ODd|IN88US=> NVrzNXg2W0GQR1XS
HCC2218 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7JXoVKSzVyPUCuO|kyOzFizszN MlPTV2FPT0WU
KNS-81-FD MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwOEGwNVEh|ryP NWXwdYZwW0GQR1XS
HCC2157 Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\hO|dWUUN3ME2wMlg1QTVzIN88US=> MWDTRW5ITVJ?
BT-474 NFruNo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwOEi4OVQh|ryP M4PIZ3NCVkeHUh?=
NCI-H748 NHjHcWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorDTWM2OD1yLkmxNkDPxE1? NVHyW2lMW0GQR1XS
EW-24 NV30TYlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwOUKwNFIh|ryP M4D1RXNCVkeHUh?=
D-263MG MlryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwOUS1NVIh|ryP MUjTRW5ITVJ?
OMC-1 M3radmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwOU[zO|Mh|ryP NVva[Wk2W0GQR1XS
NCI-H2196 NFjxPVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYC1SohlUUN3ME2wMlk4Pzd5IN88US=> MlSwV2FPT0WU
HAL-01 MlLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fxSmlEPTB;MD65PVg4OiEQvF2= NYPZWVRxW0GQR1XS
NCI-H2107 NHOxdW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTFwMEG4OVQh|ryP M{X6WnNCVkeHUh?=
LB996-RCC NXHJR4l6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\vXJRKSzVyPUGuNFgxPTFizszN MVzTRW5ITVJ?
NCI-H1395 NWXFelhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfFOpZKSzVyPUGuNVA3PyEQvF2= NHv5dXNUSU6JRWK=
CHP-126 M33zZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{S2TGlEPTB;MT6xOlE6QSEQvF2= NWjk[ZluW0GQR1XS
NB69 NI\HTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTFwMk[xOFgh|ryP MljZV2FPT0WU
CAS-1 MlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LDdGlEPTB;MT6zOFI{OSEQvF2= MoLvV2FPT0WU
JVM-3 NWjyenVwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmW1TWM2OD1zLkS3PFU2KM7:TR?= MVHTRW5ITVJ?
DMS-153 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFizZWNKSzVyPUGuOVc3PzRizszN NW\VZlJHW0GQR1XS
SK-MEL-2 NYLKNWlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPscWVQUUN3ME2xMlcyPzh7IN88US=> Ml;xV2FPT0WU
NCI-H1155 NHKzOHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HmUGlEPTB;MT63N|Y4PiEQvF2= MmX6V2FPT0WU
NCI-H1092 M1nJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEmwWHJKSzVyPUGuO|YyQDJizszN Ml\lV2FPT0WU
LU-165 NH;hc4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrEWlZKSzVyPUGuPFY1PzZizszN MYHTRW5ITVJ?
HL-60 MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LkSWlEPTB;MT65PVkxQCEQvF2= MUHTRW5ITVJ?
REH MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HVO2lEPTB;Mj6wNFU5OiEQvF2= MnHiV2FPT0WU
JVM-2 NVHxO2tqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\OTWM2OD1{LkC2NVM2KM7:TR?= MofaV2FPT0WU
MN-60 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELOXFlKSzVyPUKuNVc{ODhizszN NV3L[IlbW0GQR1XS
SCC-15 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjmTWM2OD1{LkKwNlch|ryP NX;1fnV{W0GQR1XS
SNU-C1 M2fOTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULMcIM{UUN3ME2yMlIyOzR|IN88US=> NIjq[XhUSU6JRWK=
SK-MEL-1 NIC4ZphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXLTWM2OD1{LkOyNFQ4KM7:TR?= M4jIVXNCVkeHUh?=
TGW MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHy5R3dKSzVyPUKuN|UxOjdizszN MVXTRW5ITVJ?
CA46 M{HvSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTJwN{W5Olch|ryP MonrV2FPT0WU
NCI-H23 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;w[WlEPTB;Mj64NFc6OSEQvF2= MW\TRW5ITVJ?
MMAC-SF Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor3TWM2OD1{Lki2OlI5KM7:TR?= NVvxW4hZW0GQR1XS
NCI-H2171 NUTlTm11T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETS[JZKSzVyPUOuNFM1PDhizszN M{jiXXNCVkeHUh?=
A704 MmDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\O[mlEPTB;Mz6xOFE6PCEQvF2= NISwPJFUSU6JRWK=
DB NXvWOmdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTNwMkW1O|Yh|ryP NXLyVIM{W0GQR1XS
NCI-H719 NY\ST252T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPqTWM2OD1|LkOwN|g1KM7:TR?= NEiyVIlUSU6JRWK=
MC-CAR MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTNwNUS4NVch|ryP NFWwdmFUSU6JRWK=
SIMA NVrQXWd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTNwNUi0NVYh|ryP M2rZVHNCVkeHUh?=
SW872 NXjieGE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2WwSmlEPTB;Mz63PFExOSEQvF2= NYjFU|R{W0GQR1XS
HCC1187 M1PoXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TjS2lEPTB;Mz63PFMyPSEQvF2= MYnTRW5ITVJ?
EW-13 M2fkeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1W3ZWlEPTB;Mz64N|QyPyEQvF2= M2jhSnNCVkeHUh?=
NCI-SNU-1 NHjuUXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\uTmlEPTB;ND6yNVk6QSEQvF2= NUXhSopWW0GQR1XS
NCI-H226 NFrFTlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfMTWM2OD12LkOzOlA3KM7:TR?= NWfrWWFvW0GQR1XS
RPMI-8866 M3nDdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHi[GhKSzVyPUSuN|YxOjlizszN M4TRZXNCVkeHUh?=
OCI-AML2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXTUWE2UUN3ME20MlU2OjNizszN NH\YOYxUSU6JRWK=
LU-65 NV60OYtjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETkR5FKSzVyPUSuPVMxOzNizszN NFPV[GRUSU6JRWK=
SK-N-DZ MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTVwNkO0OlUh|ryP NVPlW203W0GQR1XS
NB14 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\rS2lEPTB;NT65O|E{PSEQvF2= NX7nenFWW0GQR1XS
COLO-829 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTZwM{OzOVkh|ryP NUnLTnFkW0GQR1XS
MHH-CALL-2 NUHEdZpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTZwNUG1NFgh|ryP NHS3OmFUSU6JRWK=
NCI-H1770 MnTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn;CTWM2OD14Lk[2PVA1KM7:TR?= MnvzV2FPT0WU
ECC4 MnzoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHWZ4RYUUN3ME22MlgzOTd7IN88US=> MXvTRW5ITVJ?
A498 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTo[oNKSzVyPU[uPFcyQTJizszN NHXhbmtUSU6JRWK=
DMS-79 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHaTWM2OD15LkC0OVEzKM7:TR?= NYH3eow5W0GQR1XS
P30-OHK M{K4[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rKbmlEPTB;Nz6yNVkxPiEQvF2= NVq5SYc4W0GQR1XS
D-502MG NGnOU4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HifWlEPTB;Nz65PFM3KM7:TR?= MmTQV2FPT0WU
RCC10RGB NXznSotUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRThwME[yPEDPxE1? NEC5bYhUSU6JRWK=
U-698-M NIXWOmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRThwMkmyNlYh|ryP MY\TRW5ITVJ?
BB49-HNC M3u5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3Nb41KSzVyPUmuOFIzPjVizszN NUSyfpVIW0GQR1XS
ES1 M1K0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEeyUIxKSzVyPUmuOlg6PTZizszN MXXTRW5ITVJ?
MFM-223 MnPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;TSmlEPTB;MUCuPVkzPyEQvF2= MmLkV2FPT0WU
C2BBe1 M2e4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHm2TmlKSzVyPUGxMlM2OjNizszN M2rSO3NCVkeHUh?=
EB2 NWGxTotMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXNTWM2OD1zMj62PFgyKM7:TR?= M3rjTHNCVkeHUh?=
C8166 NF3aVZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH0U2h6UUN3ME2xN{45OzB|IN88US=> NX7MU4Z4W0GQR1XS
ES3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HhcmlEPTB;MUOuPVk4PyEQvF2= NGfBNYRUSU6JRWK=
NCI-H1650 MlPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIq2WnVKSzVyPUG2MlM4PjVizszN Moe3V2FPT0WU
Mo-T NF7GPFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO3PYtnUUN3ME2xO{41ODJ7IN88US=> M3TDR3NCVkeHUh?=
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HeLa  NHexNoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M172UVExNTFyMDDuUS=> NXz1fmI2PDhiaB?= NUT3SIxDTE2VTx?= NIS3UmNKSzVyPUWyMlkhdk1? M{f3bVIzODhyMkO1
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A498 M4LWOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XxOlUuQDBibl2= NU\FcIhWQTZiaB?= M{HBb2hEdA>? M{HGcZN2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= MkHDNlE3PDJ|N{S=
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Caki-1 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3YbYtRPS16MDDuUS=> M4nCVlk3KGh? MnHjTGNt MlPkd5VxeHKnc4Pld{B1cGVicILvcIln\XKjdHnvckBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldkB4cXSqIFnDOVDDqH[jbIXld{Bw\iB{IITvJFIxKG6P M1TaZVIyPjR{M{e0
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HMC-1.2 NF7Tc25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fB[lEuOTByMDDuUS=> MX[3NkBp MVHpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> MXGyNVI1OjF6OR?=
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U937 M4jTXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjJNU8yOC9zMECgcm0> M4i0XFczKGh? M4PUN2ROW09? M3jVbIlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MWKxPVQ2QDN3OB?=
CAL62 NVPGVmEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGjEdJIxNjFvMUCwJI5O M2LYXFczKGh? NVvQR3hYTE2VTx?= NUTONnY2TUN3ME2xMlQhdk1? MWWxPVIzOzV3Mx?=
OCUT-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mom2NE4yNTFyMDDuUS=> M{XpSVczKGh? NUfIUJExTE2VTx?= MnnVSWM2OD1{LkOgcm0> NXnzeJlFOTl{MkO1OVM>
8505C MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUOxdlU1OC5zLUGwNEBvVQ>? MlTmO|IhcA>? MlLlSG1UVw>? MoDSSWM2OD1|LkKgcm0> NUDIXGlKOTl{MkO1OVM>
ACT-1 M2nkZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\SOmlnOC5zLUGwNEBvVQ>? NX:5SJREPzJiaB?= M3XxZWROW09? MX7FR|UxRTVwNDDuUS=> NYHpR|B[OTl{MkO1OVM>
SW1736 NUDCOWJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XnVVAvOS1zMECgcm0> Mk\EO|IhcA>? Ml20SG1UVw>? MV7FR|UxRTVwNjDuUS=> NVPPd|M6OTl{MkO1OVM>

... Click to View More Cell Line Experimental Data

体内研究 BI 2536静脉注射给药多种移植瘤模型,每周一次或两次,效果都很好,通过使细胞周期停滞而抑制细胞增殖,随后诱导肿瘤细胞死亡。BI 2536按 50 mg/kg剂量处理HCT 116移植瘤,每周一次或两次,显著抑制肿瘤生长,T/C 分别为15%和0.3%。BI 2536每周处理两次BxPC-3和A549模型,也显著抑制肿瘤生长,T/C分别为5% 和14%。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验: [1]
+ 展开

体外Plk1激酶实验:

重组人Plk1 (1-603残基) 作为氮端,携带杆状病毒表达系统的GST-标记的融合蛋白通过亲和层析,使用谷胱甘肽-琼脂糖而纯化。在梯度稀释的BI 2536存在时,使用 20 ng 重组激酶,及10 μg牛奶中的酪蛋白作为底物进行Plk1 酶活性实验。在终体积为60 μL 的混合物(15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP)中30oC下进行激酶反应45分钟。加入 125 μL 冰冻的5% TCA终止反应。沉淀物转移到混合酯纤维素的多屏过滤板上,使用1% TCA冲洗实验板,然后利用放射性进行测量。绘制剂量反应曲线,而计算IC50值。
细胞实验:[1]
+ 展开
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji, PC-3,等等
  • Concentrations: 溶于DMSO, 终浓度为~1 μM
  • Incubation Time: 24,和72小时
  • Method: 使用不同浓度BI 2536处理细胞24和72小时。 在荧光分光光度计中测量Alamar Blue染料转换而测定细胞生长。为了测定培养基中DNA含量,细胞悬液在80%乙醇中混合, 使用溶于PBS的0.25% Triton X-100处理5分钟,然后与0.1% RNase 和溶于PBS的 10 μg/mL碘化丙啶在室温下温育20分钟。通过流式细胞仪分析而测定细胞周期谱。
    (Only for Reference)
动物实验:[1]
+ 展开
  • Animal Models: 皮下注射HCT 116, NCI-H460, 或A549 细胞的雌性BomTac:NMRI-Foxn1nu 小鼠
  • Formulation: 在盐酸(0.1 N)中配制,然后在0.9% NaCl中稀释。
  • Dosages: ~50 mg/kg
  • Administration: 静脉注射,每周一到两次
    (Only for Reference)

溶解度 (25°C)

体外 Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
30% PEG 400+0.5% Tween 80+5% Propylene glycol
15mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 521.66
化学式

C28H39N7O3

CAS号 755038-02-9
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia Myeloid Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • 回答:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

PLK Inhibitors with Unique Features

相关PLK产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID