Sorafenib
别名: NSC-724772,BAY 43-9006 中文名称：索拉非尼
Sorafenib是Raf-1和B-Raf的多重激酶抑制剂，无细胞试验中IC50分别为6 nM和22 nM。Sorafenib 还可抑制VEGFR-2、VEGFR-3、PDGFR-β、Flt-3和c-KIT，对应的IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM。Sorafenib 可诱导autophagy、apoptosis并激活ferroptosis，Sorafenib 具有抗肿瘤活性。
Sorafenib Chemical Structure
CAS: 284461-73-0
客户使用Selleck的Sorafenib发表文献522篇
产品质控
批次：
纯度：
99.89%
99.89
Sorafenib相关产品
| 相关靶点 | C-Raf/Raf-1 B-Raf A-raf | 点击展开 |
|---|---|---|
| 相关化合物库 | 激酶抑制剂库 MAPK抑制剂库 细胞周期化合物库 TGF-beta/Smad信号通路库 抗阿尔茨海默病化合物库 | 点击展开 |
相关信号通路图
Raf抑制剂选择性比较
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| OS-RC-2 | Growth Inhibition Assay | IC50=9.11243 μM | SANGER | ||
| LC-1F | Growth Inhibition Assay | IC50=9.10834 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=8.76353 μM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=8.63746 μM | SANGER | ||
| NB14 | Growth Inhibition Assay | IC50=8.63133 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=8.40002 μM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=7.84511 μM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=7.76503 μM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50=7.62663 μM | SANGER | ||
| NB1 | Growth Inhibition Assay | IC50=7.40407 μM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=7.05989 μM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=7.05676 μM | SANGER | ||
| SIMA | Growth Inhibition Assay | IC50=7.00101 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=6.61062 μM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=6.52849 μM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=6.45866 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=6.31839 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=6.25266 μM | SANGER | ||
| SR | Growth Inhibition Assay | IC50=6.00678 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=5.95682 μM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50=5.73568 μM | SANGER | ||
| JAR | Growth Inhibition Assay | IC50=5.50824 μM | SANGER | ||
| NCI-H510A | Growth Inhibition Assay | IC50=5.41685 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=5.24929 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=5.13227 μM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=5.07294 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=4.48905 μM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=4.40484 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=4.28798 μM | SANGER | ||
| BC-3 | Growth Inhibition Assay | IC50=4.23391 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=4.16815 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=3.88198 μM | SANGER | ||
| ST486 | Growth Inhibition Assay | IC50=3.83673 μM | SANGER | ||
| BC-1 | Growth Inhibition Assay | IC50=3.7402 μM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50=3.66099 μM | SANGER | ||
| MRK-nu-1 | Growth Inhibition Assay | IC50=3.61468 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=3.47509 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=3.13162 μM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=3.12003 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=3.06299 μM | SANGER | ||
| MFH-ino | Growth Inhibition Assay | IC50=2.92185 μM | SANGER | ||
| KMOE-2 | Growth Inhibition Assay | IC50=2.8135 μM | SANGER | ||
| L-540 | Growth Inhibition Assay | IC50=2.75789 μM | SANGER | ||
| K052 | Growth Inhibition Assay | IC50=2.74616 μM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=2.69609 μM | SANGER | ||
| SIG-M5 | Growth Inhibition Assay | IC50=2.42242 μM | SANGER | ||
| NCI-H2171 | Growth Inhibition Assay | IC50=2.39764 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=2.3162 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=2.21393 μM | SANGER | ||
| D-247MG | Growth Inhibition Assay | IC50=2.1448 μM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=1.8842 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=1.8098 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=1.63812 μM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50=1.61726 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=1.59165 μM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=1.47935 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=1.37648 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=1.35578 μM | SANGER | ||
| NCI-H1436 | Growth Inhibition Assay | IC50=1.21678 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=1.20809 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=1.02098 μM | SANGER | ||
| GDM-1 | Growth Inhibition Assay | IC50=0.90698 μM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50=0.88818 μM | SANGER | ||
| HOP-62 | Growth Inhibition Assay | IC50=0.85088 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=0.65613 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=0.5636 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=0.47073 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.25022 μM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=0.07416 μM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=0.03184 μM | SANGER | ||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=0.00418 μM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=0.00000303 μM | SANGER | ||
| NCI-SNU-16 | Growth Inhibition Assay | IC50=9.21026 μM | SANGER | ||
| SHP-77 | Growth Inhibition Assay | IC50=9.71662 μM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=9.7561 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=9.76029 μM | SANGER | ||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=10.4745 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=10.5441 μM | SANGER | ||
| NB7 | Growth Inhibition Assay | IC50=10.7526 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=11.1216 μM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=11.3876 μM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=11.9044 μM | SANGER | ||
| CHP-126 | Growth Inhibition Assay | IC50=11.9738 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=12.0278 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=12.0985 μM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=12.5413 μM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=12.5479 μM | SANGER | ||
| NCI-H1522 | Growth Inhibition Assay | IC50=12.746 μM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50=13.2911 μM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=13.5126 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=13.6046 μM | SANGER | ||
| NCI-H1882 | Growth Inhibition Assay | IC50=13.8555 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=14.0609 μM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=14.1551 μM | SANGER | ||
| NCI-H1694 | Growth Inhibition Assay | IC50=14.4811 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=14.9616 μM | SANGER | ||
| ECC4 | Growth Inhibition Assay | IC50=15.0558 μM | SANGER | ||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=15.4131 μM | SANGER | ||
| SCH | Growth Inhibition Assay | IC50=15.4728 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=15.6534 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=16.0714 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=16.1297 μM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50=16.1661 μM | SANGER | ||
| NCI-H2141 | Growth Inhibition Assay | IC50=16.189 μM | SANGER | ||
| LC4-1 | Growth Inhibition Assay | IC50=16.6119 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=17.006 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=17.0072 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=17.1638 μM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50=17.6833 μM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=17.8344 μM | SANGER | ||
| COR-L279 | Growth Inhibition Assay | IC50=18.1362 μM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50=18.7143 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=18.8041 μM | SANGER | ||
| LU-165 | Growth Inhibition Assay | IC50=19.7008 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=20.3184 μM | SANGER | ||
| RL | Growth Inhibition Assay | IC50=20.9692 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=21.1889 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=21.3752 μM | SANGER | ||
| HUTU-80 | Growth Inhibition Assay | IC50=21.3946 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=21.3992 μM | SANGER | ||
| PF-382 | Growth Inhibition Assay | IC50=21.4403 μM | SANGER | ||
| LB373-MEL-D | Growth Inhibition Assay | IC50=21.5615 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=21.6394 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=21.8513 μM | SANGER | ||
| Daudi | Growth Inhibition Assay | IC50=21.9304 μM | SANGER | ||
| D-542MG | Growth Inhibition Assay | IC50=22.0256 μM | SANGER | ||
| U-698-M | Growth Inhibition Assay | IC50=22.4603 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=22.7366 μM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=23.8897 μM | SANGER | ||
| ECC12 | Growth Inhibition Assay | IC50=24.2803 μM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50=24.3239 μM | SANGER | ||
| IST-SL2 | Growth Inhibition Assay | IC50=24.4362 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=24.5221 μM | SANGER | ||
| DMS-153 | Growth Inhibition Assay | IC50=24.8614 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=25.0265 μM | SANGER | ||
| SK-N-DZ | Growth Inhibition Assay | IC50=26.3414 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=26.5796 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=26.8535 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=26.9828 μM | SANGER | ||
| THP-1 | Growth Inhibition Assay | IC50=27.2141 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=27.332 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50=27.6231 μM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50=29.1746 μM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=30.7278 μM | SANGER | ||
| NCI-H2227 | Growth Inhibition Assay | IC50=30.9806 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=31.4492 μM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50=32.0826 μM | SANGER | ||
| EVSA-T | Growth Inhibition Assay | IC50=32.2585 μM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=33.1101 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=33.1603 μM | SANGER | ||
| NCI-H2196 | Growth Inhibition Assay | IC50=33.2557 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=33.3135 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=33.8638 μM | SANGER | ||
| LP-1 | Growth Inhibition Assay | IC50=33.9956 μM | SANGER | ||
| A253 | Growth Inhibition Assay | IC50=34.2296 μM | SANGER | ||
| SK-MM-2 | Growth Inhibition Assay | IC50=34.9451 μM | SANGER | ||
| NCI-H1963 | Growth Inhibition Assay | IC50=35.3072 μM | SANGER | ||
| MMAC-SF | Growth Inhibition Assay | IC50=35.8785 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=36.0654 μM | SANGER | ||
| WSU-NHL | Growth Inhibition Assay | IC50=36.164 μM | SANGER | ||
| CESS | Growth Inhibition Assay | IC50=36.2848 μM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=36.5835 μM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=37.1237 μM | SANGER | ||
| MHH-CALL-2 | Growth Inhibition Assay | IC50=37.1821 μM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50=38.43 μM | SANGER | ||
| CP66-MEL | Growth Inhibition Assay | IC50=39.0733 μM | SANGER | ||
| OPM-2 | Growth Inhibition Assay | IC50=39.8432 μM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=40.3096 μM | SANGER | ||
| EC-GI-10 | Growth Inhibition Assay | IC50=41.5805 μM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=42.8406 μM | SANGER | ||
| DG-75 | Growth Inhibition Assay | IC50=43.7595 μM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=45.4058 μM | SANGER | ||
| NCI-H82 | Growth Inhibition Assay | IC50=45.5758 μM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=46.1873 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50=46.434 μM | SANGER | ||
| NCI-H1395 | Growth Inhibition Assay | IC50=46.4756 μM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=47.1405 μM | SANGER | ||
| TGW | Growth Inhibition Assay | IC50=49.0791 μM | SANGER | ||
| NCI-H748 | Growth Inhibition Assay | IC50=49.4753 μM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=49.6628 μM | SANGER | ||
| MV4-11 | Antiproliferative activity assay | IC50 = 0.00087 μM | 19754199 | ||
| MV4-11 | Cytotoxicity assay | IC50 = 0.00087 μM | 19654408 | ||
| TT | Antiproliferative activity assay | IC50 = 0.0014 μM | 18849971 | ||
| RS4-11 | Function assay | IC50 = 0.002 μM | 19654408 | ||
| MOLM13 | Function assay | IC50 = 0.002 μM | 24641103 | ||
| Sf9 | Function assay | IC50 = 0.003 μM | 21708468 | ||
| RS4-11 | Function assay | IC50 = 0.0032 μM | 19654408 | ||
| MV4-11 | Growth inhibition assay | IC50 = 0.004 μM | 29357250 | ||
| A375 | Function assay | IC50 = 0.0044 μM | 29461827 | ||
| MOLM13 | Antiproliferative activity assay | IC50 = 0.005 μM | 24641103 | ||
| MV4-11 | Function assay | IC50 = 0.007 μM | 23362959 | ||
| MV4-11 | Cytotoxicity assay | IC50 = 0.007 μM | 26342867 | ||
| HEK293 | Function assay | Kd = 0.013 μM | 19754199 | ||
| Kasumi-1 | Antiproliferative activity assay | IC50 = 0.015 μM | 20570526 | ||
| MV4-11 | Antiproliferative activity assay | IC50 = 0.015 μM | 20570526 | ||
| sf9 | Function assay | IC50 = 0.015 μM | 29266937 | ||
| sf9 | Function assay | IC50 = 0.018 μM | 21708468 | ||
| sf9 | Function assay | IC50 = 0.02 μM | 23618709 | ||
| MV4-11 | Antiproliferative activity assay | GI50 = 0.03 μM | 21708468 | ||
| Sf9 | Function assay | IC50 = 0.042 μM | 26081023 | ||
| SF9 | Function assay | IC50 = 0.043 μM | 18473434 | ||
| MV4-11 | Cytotoxicity assay | GI50 = 0.043 μM | 23618709 | ||
| MV4-11 | Function assay | GI50 = 0.043 μM | 26081023 | ||
| SF9 | Function assay | IC50 = 0.044 μM | 26081023 | ||
| SF9 | Function assay | IC50 = 0.054 μM | 21708468 | ||
| SF9 | Function assay | IC50 = 0.054 μM | 23618709 | ||
| MOLM13 | Antiproliferative activity assay | GI50 = 0.056 μM | 21708468 | ||
| MOLM13 | Antiproliferative activity assay | GI50 = 0.056 μM | 22726931 | ||
| MOLM13 | Cytotoxicity assay | GI50 = 0.056 μM | 23618709 | ||
| MOLM-13 | Function assay | GI50 = 0.056 μM | 26081023 | ||
| SF9 | Function assay | IC50 = 0.058 μM | 29266937 | ||
| WM266.4 | Antiproliferative activity assay | IC50 = 0.06 μM | 25496804 | ||
| MDA-MB-231 | Function assay | IC50 = 0.063 μM | 28431342 | ||
| SF9 | Function assay | IC50 = 0.09 μM | 29266937 | ||
| Spodoptera frugiperda | Function assay | IC50 = 0.09 μM | 26922228 | ||
| SF9 | Function assay | IC50 = 0.09 μM | 23562241 | ||
| SF9 | Function assay | IC50 = 0.1 μM | 23442188 | ||
| SF9 | Function assay | IC50 = 0.1 μM | 23442188 | ||
| HEK293 | Function assay | IC50 = 0.12 μM | 26318998 | ||
| MCF7 | Antiproliferative activity assay | IC50 = 0.19 μM | 25496804 | ||
| MV4-11 | Antiproliferative activity human | IC50 = 0.3 μM | 28242553 | ||
| HepG2 | Antiproliferative activity assay | EC50 = 0.302 μM | 27010810 | ||
| THP1 | Antiproliferative activity assay | IC50 = 0.31 μM | 20570526 | ||
| SMMC7721 | Cytotoxicity assay | IC50 = 0.37 μM | 25982075 | ||
| HT-29 | Antiproliferative activity assay | IC50 = 0.39 μM | 25778995 | ||
| sf9 | Function assay | Kd = 0.6 μM | 28109791 | ||
| T47D | Antiproliferative activity assay | IC50 = 0.61 μM | 25778995 | ||
| A549 | Cytotoxicity assay | IC50 = 0.63 μM | 25982075 | ||
| HeLa | Cytotoxicity assay | IC50 = 0.64 μM | 30015070 | ||
| WM3629 | Antiproliferative activity assay | GI50 = 0.65 μM | 20466542 | ||
| SMMC7721 | Antiproliferative activity assay | IC50 = 0.65 μM | 26342134 | ||
| WM3629 | Growth inhibition assay | GI50 = 0.78 μM | 20149658 | ||
| WM3629 | Antiproliferative activity assay | GI50 = 0.78 μM | 26810260 | ||
| MCF7 | Antiproliferative activity assay | IC50 = 0.78 μM | 25778995 | ||
| K562 | Antiproliferative activity assay | IC50 = 0.86 μM | 24315192 | ||
| COLO205 | Antiproliferative activity assay | IC50 = 0.87 μM | 25778995 | ||
| T29 | Cytotoxicity assay | IC50 = 0.9 μM | 26318998 | ||
| MDA-MB-231 | Cytotoxicity assay | IC50 = 0.94 μM | 25086238 | ||
| MDA-MB-231 | Cytotoxicity assay | IC50 = 0.94 μM | 25440879 | ||
| HepG2 | Antiproliferative activity assay | IC50 = 1.06 μM | 29628325 | ||
| BL21(DE3) | Function assay | IC50 = 1.1 μM | 19928858 | ||
| K562 | Antiproliferative activity assay | IC50 = 1.22 μM | 25778995 | ||
| MDA-MB-231 | Growth inhibition assay | GI50 = 1.26 μM | 28088086 | ||
| MDA-MB-231 | Cytotoxicity assay | GI50 = 1.26 μM | 26590508 | ||
| MDA-MB-231 | Antiproliferative activity assay | GI50 = 1.26 μM | 27017549 | ||
| SK-MEL-28 | Antiproliferative activity assay | EC50 = 1.3 μM | 18942827 | ||
| sf9 | Function assay | Kd = 1.3 μM | 28109791 | ||
| F-6-8 | Cytotoxicity assay | IC50 = 1.3 μM | 26318998 | ||
| A549 | Antiproliferative activity assay | IC50 = 1.45 μM | 26342134 | ||
| rhabdomyosarcoma | Antiviral activity assay | EC50 = 1.5 μM | 27288186 | ||
| HL-60(TB) | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| RPMI8226 | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| KM12 | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| LOXIMVI | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| HCT116 | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| HOP92 | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| SF539 | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| UACC62 | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| SF295 | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| MDA-MB-435 | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| SK-MEL-5 | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| T47D | Growth inhibition assay | GI50 = 1.58 μM | 28088086 | ||
| RPMI8266 | Cytotoxicity assay | GI50 = 1.58 μM | 26590508 | ||
| HL-60(TB) | Cytotoxicity assay | GI50 = 1.58 μM | 26590508 | ||
| KM12 | Cytotoxicity assay | GI50 = 1.58 μM | 26590508 | ||
| HCT116 | Cytotoxicity assay | GI50 = 1.58 μM | 26590508 | ||
| SF295 | Cytotoxicity assay | GI50 = 1.58 μM | 26590508 | ||
| SF539 | Cytotoxicity assay | GI50 = 1.58 μM | 26590508 | ||
| SK-MEL-2 | Cytotoxicity assay | GI50 = 1.58 μM | 26590508 | ||
| MDA-MB-435 | Cytotoxicity assay | GI50 = 1.58 μM | 26590508 | ||
| SK-MEL-5 | Cytotoxicity assay | GI50 = 1.58 μM | 26590508 | ||
| LOXIMVI | Cytotoxicity assay | GI50 = 1.58 μM | 26590508 | ||
| T47D | Cytotoxicity assay | GI50 = 1.58 μM | 26590508 | ||
| SMMC7721 | Antiproliferative activity assay | IC50 = 1.58 μM | 26753815 | ||
| LOXIMVI | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| UACC62 | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| SK-MEL-5 | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| KM12 | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| MDA-MB-435 | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| SF539 | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| SF295 | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| HCT116 | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| HOP92 | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| RPMI8226 | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| HL-60(TB) | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| T47D | Antiproliferative activity assay | GI50 = 1.58 μM | 27017549 | ||
| 7dF3 | Function assay | IC50 = 1.62 μM | 29266937 | ||
| MDA-MB-435 | Antiproliferative activity assay | IC50 = 1.67 μM | 25778995 | ||
| HL60 | Cytotoxicity assay | IC50 = 1.68 μM | 24858546 | ||
| SW579 | Antiproliferative activity human | IC50 = 1.73 μM | 28242553 | ||
| MCF7 | Antiproliferative activity assay | IC50 = 1.88 μM | 25637123 | ||
| A375P | Antiproliferative activity assay | IC50 = 1.9 μM | 24128410 | ||
| A549 | Cytotoxicity assay | IC50 = 1.92 μM | 24826815 | ||
| HCT116 | Antiproliferative activity assay | IC50 = 2 μM | 22808911 | ||
| MDA-MB-231 | Cytotoxicity assay | IC50 = 2 μM | 23454017 | ||
| NCI-H23 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| NCI-H522 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| HOP62 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| NCI-H226 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| HT-29 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| U251 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| COLO205 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| CCRF-CEM | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| MALME-3M | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| M14 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| UACC257 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| PC3 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| SK-MEL-2 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| MDA-MB-468 | Growth inhibition assay | GI50 = 2 μM | 28088086 | ||
| CCRF-CEM | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| NCI-H23 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| NCI-H522 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| COLO205 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| HT-29 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| SK-MEL-28 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| HOP62 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| UACC257 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| NCI-H226 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| U251 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| PC3 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| M14 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| MDA-MB-468 | Cytotoxicity assay | GI50 = 2 μM | 26590508 | ||
| PC3 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| MALME-3M | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| U251 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| UACC257 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| SK-MEL-2 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| COLO205 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| NCI-H23 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| HT-29 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| M14 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| NCI-H226 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| HOP62 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| MDA-MB-468 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| CCRF-CEM | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| NCI-H522 | Antiproliferative activity assay | GI50 = 2 μM | 27017549 | ||
| A549 | Antiproliferative activity assay | IC50 = 2.02 μM | 26753815 | ||
| MDA-MB-435 | Growth inhibition assay | IC50 = 2.11 μM | 29189002 | ||
| NCI-H460 | Antiproliferative activity assay | IC50 = 2.19 μM | 30216849 | ||
| H460 | Cytotoxicity assay | IC50 = 2.19 μM | 24826815 | ||
| H460 | Cytotoxicity assay | IC50 = 2.19 μM | 25086238 | ||
| H460 | Cytotoxicity assay | IC50 = 2.19 μM | 25440879 | ||
| A375 | Toxicity assay | IC50 = 2.2 μM | 19654408 | ||
| H460 | Antiproliferative activity assay | IC50 = 2.25 μM | 26991938 | ||
| HCT116 | Antiproliferative activity assay | IC50 = 2.3 μM | 23260578 | ||
| MKN45 | Antiproliferative activity assay | IC50 = 2.32 μM | 30216849 | ||
| MKN45 | Cytotoxicity assay | IC50 = 2.32 μM | 24826815 | ||
| MKN45 | Cytotoxicity assay | IC50 = 2.32 μM | 25086238 | ||
| MKN45 | Cytotoxicity assay | IC50 = 2.32 μM | 25440879 | ||
| U937 | Antiproliferative activity assay | GI50 = 2.34 μM | 29459144 | ||
| A375 | Antiproliferative activity assay | IC50 = 2.4 μM | 22808911 | ||
| HeLa | Growth inhibition assay | IC50 = 2.44 μM | 29102175 | ||
| MDA-MB-231 | Cytotoxicity assay | IC50 = 2.5 μM | 22414612 | ||
| MCF7 | Antiproliferative activity assay | IC50 = 2.51 μM | 30216849 | ||
| UO31 | Antiproliferative activity assay | IC50 = 2.51 μM | 30216849 | ||
| NCI-H322M | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| NCI-H460 | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| KM12 | Growth inhibition assay | TGI = 2.51 μM | 28088086 | ||
| LOXIMVI | Growth inhibition assay | TGI = 2.51 μM | 28088086 | ||
| EKVX | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| HCT116 | Growth inhibition assay | TGI = 2.51 μM | 28088086 | ||
| SW620 | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| SF268 | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| SF539 | Growth inhibition assay | TGI = 2.51 μM | 28088086 | ||
| A498 | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| UACC62 | Growth inhibition assay | TGI = 2.51 μM | 28088086 | ||
| IGROV1 | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| HCT15 | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| SK-MEL-28 | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| SK-MEL-28 | Growth inhibition assay | TGI = 2.51 μM | 28088086 | ||
| ACHN | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| SK-MEL-5 | Growth inhibition assay | TGI = 2.51 μM | 28088086 | ||
| NCI/ADR-RES | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| MCF7 | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| SN12C | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| Hs 578T | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| SKOV3 | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| UO31 | Growth inhibition assay | GI50 = 2.51 μM | 28088086 | ||
| NCI-H460 | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| HCT15 | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| SW620 | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| SF268 | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| IGROV1 | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| OVCAR8 | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| NCI/ADR-RES | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| SKOV3 | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| SN12C | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| NCI-H322M | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| MCF7 | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| UO31 | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| Hs578T | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| A498 | Cytotoxicity assay | GI50 = 2.51 μM | 26590508 | ||
| A498 | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| SKOV3 | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| UO31 | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| NCI-ADR-RES | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| SN12C | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| IGROV1 | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| ACHN | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| OVCAR8 | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| SK-MEL-28 | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| NCI-H322M | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| SF268 | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| HCT15 | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| NCI-H460 | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| SW620 | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| EKVX | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| MCF7 | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| Hs 578T | Antiproliferative activity assay | GI50 = 2.51 μM | 27017549 | ||
| HT-29 | Antiproliferative activity assay | IC50 = 2.58 μM | 29886324 | ||
| A375P | Antiproliferative activity assay | GI50 = 2.58 μM | 26810260 | ||
| TPC1 | Antiproliferative activity assay | EC50 = 2.6 μM | 22559926 | ||
| Hep3B | Growth inhibition assay | IC50 = 2.63 μM | 29102175 | ||
| A375P | Antiproliferative activity assay | IC50 = 2.7 μM | 22460030 | ||
| U937 | Antiproliferative activity assay | GI50 = 2.74 μM | 26318067 | ||
| U937 | Cytotoxicity assay | GI50 = 2.74 μM | 24878193 | ||
| MCF7 | Growth inhibition assay | IC50 = 2.78 μM | 29102175 | ||
| MDA-MB-231 | Antiproliferative activity assay | IC50 = 2.8 μM | 29202403 | ||
| HepG2 | Antiproliferative activity assay | IC50 = 2.84 μM | 28242553 | ||
| U937 | Growth inhibition assay | GI50 = 2.85 μM | 22014755 | ||
| A549 | Cytotoxicity assay | IC50 = 2.92 μM | 28927801 | ||
| A549 | Cytotoxicity assay | IC50 = 2.92 μM | 27777009 | ||
| ZR75-30 | Growth inhibition assay | IC50 = 2.96 μM | 29102175 | ||
| PC3 | Cytotoxicity assay | IC50 = 3.03 μM | 28340913 | ||
| MDA-MB-231 | Antiproliferative activity assay | IC50 = 3.08 μM | 26991938 | ||
| A549 | Growth inhibition assay | IC50 = 3.1 μM | 29102175 | ||
| K562 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| MOLT4 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| A549/ATCC | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| RPMI8226 | Growth inhibition assay | TGI = 3.16 μM | 28088086 | ||
| SR | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| HOP62 | Growth inhibition assay | TGI = 3.16 μM | 28088086 | ||
| NCI-H226 | Growth inhibition assay | TGI = 3.16 μM | 28088086 | ||
| U251 | Growth inhibition assay | TGI = 3.16 μM | 28088086 | ||
| COLO205 | Growth inhibition assay | TGI = 3.16 μM | 28088086 | ||
| M14 | Growth inhibition assay | TGI = 3.16 μM | 28088086 | ||
| HCC2998 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| SNB75 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| 786-0 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| A498 | Growth inhibition assay | TGI = 3.16 μM | 28088086 | ||
| HCT15 | Growth inhibition assay | TGI = 3.16 μM | 28088086 | ||
| OVCAR3 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| OVCAR4 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| Caki1 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| SNB19 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| OVCAR5 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| DU145 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| OVCAR8 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| SN12C | Growth inhibition assay | TGI = 3.16 μM | 28088086 | ||
| MDA-MB-231 | Growth inhibition assay | TGI = 3.16 μM | 28088086 | ||
| RXF393 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| BT549 | Growth inhibition assay | GI50 = 3.16 μM | 28088086 | ||
| K562 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| MOLT4 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| SNB19 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| SR | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| A549 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| OVCAR3 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| OVCAR4 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| SNB75 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| OVCAR5 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| DU145 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| 786-0 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| BT549 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| ACHN | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| Caki1 | Cytotoxicity assay | GI50 = 3.16 μM | 26590508 | ||
| 786-0 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| LOXIMVI | Antiproliferative activity assay | TGI = 3.16 μM | 27017549 | ||
| Caki1 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| OVCAR5 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| RXF393 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| SNB75 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| OVCAR3 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| SNB19 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| SK-MEL-5 | Antiproliferative activity assay | TGI = 3.16 μM | 27017549 | ||
| OVCAR4 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| SK-MEL-2 | Antiproliferative activity assay | TGI = 3.16 μM | 27017549 | ||
| BT549 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| MOLT4 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| K562 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| HCC2998 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| HCC2998 | Antiproliferative activity assay | TGI = 3.16 μM | 27017549 | ||
| A549/ATCC | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| DU145 | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| SR | Antiproliferative activity assay | GI50 = 3.16 μM | 27017549 | ||
| MCF7 | Cytotoxicity assay | IC50 = 3.18 μM | 28927801 | ||
| PC3 | Cytotoxicity assay | IC50 = 3.18 μM | 28927801 | ||
| MCF7 | Cytotoxicity assay | IC50 = 3.18 μM | 27777009 | ||
| A549 | Antiproliferative activity assay | IC50 = 3.19 μM | 25778995 | ||
| PC3 | Cytotoxicity assay | IC50 = 3.24 μM | 27777009 | ||
| HeLa | Function assay | IC50 = 3.3 μM | 15225706 | ||
| HeLa | Function assay | IC50 = 3.3 μM | 15225706 | ||
| LoVo | Cytotoxicity assay | IC50 = 3.3 μM | 23454017 | ||
| A375 | Antiproliferative activity assay | IC50 = 3.36 μM | 29602674 | ||
| HT-29 | Antiproliferative activity assay | IC50 = 3.37 μM | 26991938 | ||
| FLT3 gene-deficient U937 | Antiproliferative activity assay | GI50 = 3.4 μM | 21708468 | ||
| FLT3 negative U937 | Cytotoxicity assay | GI50 = 3.4 μM | 23618709 | ||
| U937 | Cytotoxicity assay | GI50 = 3.4 μM | 26081023 | ||
| A375P | Antiproliferative activity assay | GI50 = 3.4 μM | 29459144 | ||
| ACHN | Cytotoxicity assay | IC50 = 3.4 μM | 29517908 | ||
| ACHN | Cytotoxicity assay | IC50 = 3.4 μM | 29297688 | ||
| HepG2 | Function assay | IC50 = 3.4 μM | 26071861 | ||
| A375P | Cytotoxicity assay | GI50 = 3.4 μM | 24878193 | ||
| HepG2 | Cytotoxicity assay | IC50 = 3.44 μM | 28927801 | ||
| HepG2 | Cytotoxicity assay | IC50 = 3.44 μM | 27777009 | ||
| ACHN | Cytotoxicity assay | IC50 = 3.5 μM | 29786436 | ||
| HepG2 | Antiproliferative activity assay | IC50 = 3.5 μM | 25462265 | ||
| HT-29 | Cytotoxicity assay | IC50 = 3.61 μM | 24826815 | ||
| HT-29 | Antiproliferative activity assay | IC50 = 3.61 μM | 30216849 | ||
| HT-29 | Cytotoxicity assay | IC50 = 3.61 μM | 25086238 | ||
| HT-29 | Cytotoxicity assay | IC50 = 3.61 μM | 25440879 | ||
| MCF7 | Anticancer activity assay | IC50 = 3.64 μM | 29549841 | ||
| Sf9 | Function assay | IC50 = 3.8 μM | 21708468 | ||
| Sf9 | Function assay | IC50 = 3.8 μM | 23618709 | ||
| Sf9 | Function assay | IC50 = 3.8 μM | 26081023 | ||
| A2058 | Cytotoxicity assay | IC50 = 3.8 μM | 22708987 | ||
| NCI-H460 | Cytotoxicity assay | IC50 = 3.9 μM | 23454017 | ||
| SK-MEL-30 | Cytotoxicity assay | IC50 = 3.9 μM | 29461827 | ||
| HT-29 | Anticancer activity assay | IC50 = 3.97 μM | 29549841 | ||
| SF268 | Growth inhibition assay | TGI = 3.98 μM | 28088086 | ||
| SNB75 | Growth inhibition assay | TGI = 3.98 μM | 28088086 | ||
| OVCAR3 | Growth inhibition assay | TGI = 3.98 μM | 28088086 | ||
| SNB19 | Growth inhibition assay | TGI = 3.98 μM | 28088086 | ||
| Hs 578T | Growth inhibition assay | TGI = 3.98 μM | 28088086 | ||
| TK10 | Growth inhibition assay | GI50 = 3.98 μM | 28088086 | ||
| BT549 | Growth inhibition assay | TGI = 3.98 μM | 28088086 | ||
| Caki1 | Antiproliferative activity assay | TGI = 3.98 μM | 27017549 | ||
| TK10 | Antiproliferative activity assay | GI50 = 3.98 μM | 27017549 | ||
| MDA-MB-435 | Antiproliferative activity assay | TGI = 3.98 μM | 27017549 | ||
| HCT116 | Antiproliferative activity assay | TGI = 3.98 μM | 27017549 | ||
| MDA-MB-231 | Antiproliferative activity assay | TGI = 3.98 μM | 27017549 | ||
| HepG2 | Cytotoxicity assay | IC50 = 4 μM | 23454017 | ||
| HT-29 | Cytotoxicity assay | IC50 = 4 μM | 23454017 | ||
| A549 | Cytotoxicity assay | IC50 = 4 μM | 23454017 | ||
| HuH7 | Cytotoxicity assay | GI50 = 4 μM | 23726028 | ||
| PC3 | Antiproliferative activity assay | IC50 = 4.13 μM | 25778995 | ||
| HeLa | Cytotoxicity assay | IC50 = 4.163 μM | 23362959 | ||
| MDA-MB-436 | Antiproliferative activity assay | IC50 = 4.2 μM | 29202403 | ||
| MCF7 | Cytotoxicity assay | IC50 = 4.21 μM | 27043268 | ||
| MCF7 | Cytotoxicity assay | IC50 = 4.21 μM | 28340913 | ||
| LOXIMVI | Antiproliferative activity assay | IC50 = 4.25 μM | 25778995 | ||
| OVCAR4 | Cytotoxicity assay | TGI = 4.31 μM | 26590508 | ||
| WM1361 | Antiproliferative activity assay | GI50 = 4.345 μM | 20148563 | ||
| WM266.4 | Growth inhibition assay | GI50 = 4.5 μM | 20199087 | ||
| HepG2 | Cytotoxicity assay | GI50 = 4.5 μM | 23726028 | ||
| A549 | Antiproliferative activity assay | IC50 = 4.5 μM | 23260578 | ||
| LS174T | Function assay | IC50 = 4.52 μM | 29266937 | ||
| 8505C | Antiproliferative activity assay | IC50 = 4.7 μM | 29032031 | ||
| OVCAR8 | Cytotoxicity assay | TGI = 4.73 μM | 26590508 | ||
| MDA-MB-231 | Cytotoxicity assay | IC50 = 4.77 μM | 20435479 | ||
| B16-F1 | Antiproliferative activity assay | IC50 = 4.9 μM | 18477505 | ||
| WM164 | Antiproliferative activity assay | IC50 = 4.9 μM | 17561392 | ||
| B16-F1 | Antiproliferative activity assay | IC50 = 4.9 μM | 20056548 | ||
| MDA-MB-468 | Cytotoxicity assay | IC50 = 4.9 μM | 26159483 | ||
| 786-O | Cytotoxicity assay | IC50 = 4.9 μM | 29517908 | ||
| 786-O | Cytotoxicity assay | IC50 = 4.9 μM | 29297688 | ||
| WM266.4 | Antiproliferative activity assay | GI50 = 4.933 μM | 20148563 | ||
| WM266.4 | Growth inhibition assay | IC50 = 5 μM | 19323560 | ||
| WM164 | Antiproliferative activity assay | IC50 = 5 μM | 20056548 | ||
| HepG2 | Antiproliferative activity assay | IC50 = 5 μM | 23260578 | ||
| HepG2 | Antiproliferative activity assay | IC50 = 5 μM | 23932071 | ||
| NCI-H23 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| NCI-H322M | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| NCI-H460 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| NCI-H522 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| HT-29 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| CCRF-CEM | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| SW620 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| HOP92 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| 786-0 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| MDA-MB-435 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| PC3 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| UACC257 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| SKOV3 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| RXF393 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| T47D | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| MDA-MB-468 | Growth inhibition assay | TGI = 5.01 μM | 28088086 | ||
| UACC62 | Antiproliferative activity assay | TGI = 5.01 μM | 27017549 | ||
| UACC257 | Antiproliferative activity assay | TGI = 5.01 μM | 27017549 | ||
| SK-MEL-5 | Antiproliferative activity assay | LC50 = 5.01 μM | 27017549 | ||
| M14 | Antiproliferative activity assay | TGI = 5.01 μM | 27017549 | ||
| NCI-H23 | Antiproliferative activity assay | TGI = 5.01 μM | 27017549 | ||
| SF295 | Antiproliferative activity assay | TGI = 5.01 μM | 27017549 | ||
| HOP92 | Antiproliferative activity assay | TGI = 5.01 μM | 27017549 | ||
| BT549 | Antiproliferative activity assay | TGI = 5.01 μM | 27017549 | ||
| MDA-MB-231 | Cytotoxicity assay | IC50 = 5.1 μM | 26159483 | ||
| DU145 | Cytotoxicity assay | IC50 = 5.1 μM | 22708987 | ||
| A549 | Cytotoxicity assay | IC50 = 5.21 μM | 20181414 | ||
| HeLa | Cytotoxicity assay | IC50 = 5.23 μM | 26342867 | ||
| 786-O | Cytotoxicity assay | IC50 = 5.3 μM | 29786436 | ||
| HCT116 | Antiproliferative activity assay | GI50 = 5.4 μM | 15225706 | ||
| A375 | Antiproliferative activity assay | IC50 = 5.4 μM | 18477505 | ||
| SK-MEL-188 | Antiproliferative activity assay | IC50 = 5.4 μM | 17561392 | ||
| A375 | Antiproliferative activity assay | IC50 = 5.4 μM | 20056548 | ||
| MCF7 | Cytotoxicity assay | IC50 = 5.5 μM | 26159483 | ||
| A375 | Antiproliferative activity assay | IC50 = 5.58 μM | 19464887 | ||
| A375P | Cytotoxicity assay | IC50 = 5.58 μM | 20797858 | ||
| A375P | Antiproliferative activity assay | GI50 = 5.58 μM | 21353571 | ||
| A375P | Growth inhibition assay | GI50 = 5.58 μM | 22014755 | ||
| A375P | Growth inhibition assay | GI50 = 5.58 μM | 20149658 | ||
| A375P | Antiproliferative activity assay | GI50 = 5.58 μM | 20466542 | ||
| A375P | Antiproliferative activity assay | IC50 = 5.6 μM | 19857963 | ||
| A375P | Antiproliferative activity assay | IC50 = 5.6 μM | 21592628 | ||
| A375P | Antiproliferative activity assay | IC50 = 5.6 μM | 22033063 | ||
| A375P | Cytotoxicity assay | IC50 = 5.6 μM | 19897366 | ||
| A375P | Antiproliferative activity assay | IC50 = 5.6 μM | 22647720 | ||
| HCT116 | Cytotoxicity assay | IC50 = 5.65 μM | 24215818 | ||
| SH-SY5Y | Antiproliferative activity assay | IC50 = 5.73 μM | 24315192 | ||
| HepG2 | Cytotoxicity assay | IC50 = 5.74 μM | 25461318 | ||
| Bel7402 | Cytotoxicity assay | IC50 = 5.8 μM | 23454017 | ||
| HT-29 | Cytotoxicity assay | IC50 = 5.9 μM | 28865276 | ||
| melanoma | Growth inhibition assay | IC50 = 6.1 μM | 16392826 | ||
| K562 | Antiproliferative activity assay | GI50 = 6.2 μM | 21708468 | ||
| HepG2 | Cytotoxicity assay | IC50 = 6.2 μM | 28865276 | ||
| A549 | Anticancer activity assay | IC50 = 6.21 μM | 29549841 | ||
| SMMC7721 | Antiproliferative activity assay | IC50 = 6.23 μM | 22721924 | ||
| HepG2 | Antiproliferative activity assay | IC50 = 6.3 μM | 23932071 | ||
| SF295 | Growth inhibition assay | TGI = 6.31 μM | 28088086 | ||
| SK-MEL-2 | Growth inhibition assay | TGI = 6.31 μM | 28088086 | ||
| OVCAR5 | Growth inhibition assay | TGI = 6.31 μM | 28088086 | ||
| UO31 | Growth inhibition assay | TGI = 6.31 μM | 28088086 | ||
| A498 | Antiproliferative activity assay | TGI = 6.31 μM | 27017549 | ||
| MALME-3M | Antiproliferative activity assay | TGI = 6.31 μM | 27017549 | ||
| U251 | Antiproliferative activity assay | TGI = 6.31 μM | 27017549 | ||
| SK-MEL-2 | Antiproliferative activity assay | LC50 = 6.31 μM | 27017549 | ||
| RPMI8226 | Antiproliferative activity assay | TGI = 6.31 μM | 27017549 | ||
| HCC2998 | Antiproliferative activity assay | LC50 = 6.31 μM | 27017549 | ||
| NCI-H522 | Antiproliferative activity assay | TGI = 6.31 μM | 27017549 | ||
| HUVEC | Antiproliferative activity assay | IC50 = 6.42 μM | 23644219 | ||
| A549 | Cytotoxicity assay | IC50 = 6.53 μM | 27043268 | ||
| A549 | Cytotoxicity assay | IC50 = 6.53 μM | 28340913 | ||
| LoVo | Antiproliferative activity assay | IC50 = 6.56 μM | 24315192 | ||
| A375 | Function assay | IC50 = 6.599 μM | 21807507 | ||
| HCT116 | Function assay | GI50 = 6.6 μM | 15225706 | ||
| HepG2 | Cytotoxicity assay | IC50 = 6.7 μM | 26159483 | ||
| BCPAP | Antiproliferative activity assay | IC50 = 6.7 μM | 29032031 | ||
| A549 | Cytotoxicity assay | IC50 = 6.7 μM | 28865276 | ||
| PC3 | Cytotoxicity assay | IC50 = 6.8 μM | 23021967 | ||
| SGC7901 | Cytotoxicity assay | IC50 = 6.9 μM | 23454017 | ||
| OS-RC2 | Cytotoxicity assay | IC50 = 7 μM | 29517908 | ||
| OS-RC2 | Cytotoxicity assay | IC50 = 7 μM | 29297688 | ||
| COLO205 | Antiproliferative activity human | IC50 = 7.04 μM | 28242553 | ||
| rhabdomyosarcoma | Cytotoxicity activity against human | CC50 = 7.05 μM | 27288186 | ||
| HuH7 | Cytotoxicity assay | IC50 = 7.1 μM | 26159483 | ||
| MDA-MB-231 | Antiproliferative activity assay | IC50 = 7.18 μM | 22721924 | ||
| FLT3-negative K562 | Cytotoxicity assay | GI50 = 7.3 μM | 23618709 | ||
| K562 | Function assay | GI50 = 7.3 μM | 26081023 | ||
| K562 | Function assay | GI50 = 7.3 μM | 26081023 | ||
| MCF7 | Antiproliferative activity assay | IC50 = 7.33 μM | 23644219 | ||
| A549 | Cytotoxicity assay | TGI = 7.36 μM | 26590508 | ||
| WI38 | Cytotoxicity assay | IC50 = 7.54 μM | 24826815 | ||
| A375 | Cytotoxicity assay | IC50 = 7.56 μM | 24215818 | ||
| MDA-MB-231 | Cytotoxicity assay | IC50 = 7.62 μM | 20181414 | ||
| 786-0 | Cytotoxicity assay | TGI = 7.62 μM | 26590508 | ||
| HS27 | Antiproliferative activity assay | IC50 = 7.8 μM | 19857963 | ||
| HS27 | Cytotoxicity assay | IC50 = 7.8 μM | 19897366 | ||
| HCT116 | Cytotoxicity assay | IC50 = 7.8 μM | 22483592 | ||
| HS27 | Antiproliferative activity assay | IC50 = 7.85 μM | 19464887 | ||
| HS27 | Antiproliferative activity assay | GI50 = 7.85 μM | 21353571 | ||
| A549/ATCC | Growth inhibition assay | TGI = 7.94 μM | 28088086 | ||
| DU145 | Growth inhibition assay | TGI = 7.94 μM | 28088086 | ||
| NCI/ADR-RES | Growth inhibition assay | TGI = 7.94 μM | 28088086 | ||
| MCF7 | Growth inhibition assay | TGI = 7.94 μM | 28088086 | ||
| PC3 | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| UO31 | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| NCI-ADR-RES | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| LOXIMVI | Antiproliferative activity assay | LC50 = 7.94 μM | 27017549 | ||
| SK-MEL-28 | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| KM12 | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| COLO205 | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| HT-29 | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| NCI-H226 | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| HOP62 | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| T47D | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| MDA-MB-468 | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| EKVX | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| MCF7 | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| Hs 578T | Antiproliferative activity assay | TGI = 7.94 μM | 27017549 | ||
| MGC803 | Antiproliferative activity assay | IC50 = 7.99 μM | 26560049 | ||
| HCT116 | Antiproliferative activity assay | IC50 = 8.08 μM | 24440479 | ||
| PC3 | Cytotoxicity assay | IC50 = 8.08 μM | 27043268 | ||
| HCT116 | Antiproliferative activity assay | IC50 = 8.08 μM | 23644219 | ||
| WM266.4 | Antiproliferative activity assay | GI50 = 8.1 μM | 23025996 | ||
| WM266.4 | Antiproliferative activity assay | GI50 = 8.12 μM | 22583669 | ||
| Ketr3 | Antiproliferative activity assay | IC50 = 8.27 μM | 30216849 | ||
| A375 | Antiproliferative activity assay | IC50 = 8.27 μM | 30216849 | ||
| HepG2 | Antiproliferative activity assay | IC50 = 8.27 μM | 30216849 | ||
| MX1 | Antiproliferative activity assay | IC50 = 8.27 μM | 30216849 | ||
| MX1 | Cytotoxicity assay | IC50 = 8.27 μM | 24675135 | ||
| WM266.4 | Growth inhibition assay | GI50 = 8.3 μM | 22361686 | ||
| PLC/PRF/5 | Cytotoxicity assay | IC50 = 8.3 μM | 21531053 | ||
| A375 | Antiproliferative activity assay | IC50 = 8.33 μM | 29886324 | ||
| HCT116 | Cytotoxicity assay | IC50 = 8.41 μM | 29631788 | ||
| WI38 | Cytotoxicity assay | IC50 = 8.42 μM | 26991938 | ||
| HepG2 | Cytotoxicity assay | IC50 = 8.42 μM | 27162123 | ||
| HepG2 | Cytotoxicity assay | IC50 = 8.42 μM | 23871909 | ||
| HT-29 | Antiproliferative activity assay | IC50 = 8.44 μM | 29602674 | ||
| HepG2 | Cytotoxicity assay | IC50 = 8.67 μM | 24675135 | ||
| MCF7 | Cytotoxicity assay | IC50 = 8.83 μM | 20435479 | ||
| MCF7 | Cytotoxicity assay | IC50 = 9.12 μM | 24300920 | ||
| HepG2 | Antiproliferative activity assay | IC50 = 9.14 μM | 26560049 | ||
| A375 | Cytotoxicity assay | IC50 = 9.17 μM | 24675135 | ||
| MGC803 | Antiproliferative activity assay | IC50 = 9.2 μM | 29032031 | ||
| SKOV3 | Cytotoxicity assay | IC50 = 9.25 μM | 24300920 | ||
| RS4:11 | Function assay | GI50 = 9.3 μM | 26081023 | ||
| RS4:11 | Cytotoxicity assay | GI50 = 9.3 μM | 23618709 | ||
| MIAPaCa2 | Antiproliferative activity assay | IC50 = 9.32 μM | 29032031 | ||
| PANC1 | Growth inhibition assay | IC50 = 9.32 μM | 29102175 | ||
| MHCC97H | Growth inhibition assay | IC50 = 9.32 μM | 29102175 | ||
| RS4:11 | Antiproliferative activity assay | GI50 = 9.4 μM | 21708468 | ||
| Hep3B | Cytotoxicity assay | IC50 = 9.4 μM | 28865276 | ||
| LoVo | Growth inhibition assay | IC50 = 9.47 μM | 29102175 | ||
| SMMC7721 | Antiproliferative activity assay | IC50 = 9.96 μM | 25637123 | ||
| MCF7 | Cytotoxicity assay | TGI = 9.97 μM | 26590508 | ||
| IGROV1 | Growth inhibition assay | TGI = 10 μM | 28088086 | ||
| ACHN | Growth inhibition assay | TGI = 10 μM | 28088086 | ||
| TK10 | Growth inhibition assay | TGI = 10 μM | 28088086 | ||
| 786-0 | Antiproliferative activity assay | TGI = 10 μM | 27017549 | ||
| SN12C | Antiproliferative activity assay | TGI = 10 μM | 27017549 | ||
| Caki1 | Antiproliferative activity assay | LC50 = 10 μM | 27017549 | ||
| TK10 | Antiproliferative activity assay | TGI = 10 μM | 27017549 | ||
| RXF393 | Antiproliferative activity assay | TGI = 10 μM | 27017549 | ||
| OVCAR8 | Antiproliferative activity assay | TGI = 10 μM | 27017549 | ||
| SNB75 | Antiproliferative activity assay | TGI = 10 μM | 27017549 | ||
| NCI-H322M | Antiproliferative activity assay | TGI = 10 μM | 27017549 | ||
| MDA-MB-435 | Antiproliferative activity assay | LC50 = 10 μM | 27017549 | ||
| SF539 | Antiproliferative activity assay | TGI = 10 μM | 27017549 | ||
| SF268 | Antiproliferative activity assay | TGI = 10 μM | 27017549 | ||
| NCI-H460 | Antiproliferative activity assay | TGI = 10 μM | 27017549 | ||
| DU145 | Antiproliferative activity assay | TGI = 10 μM | 27017549 | ||
| K1 | Antiproliferative activity assay | IC50 = 10.2 μM | 29032031 | ||
| Bel7402 | Cytotoxicity assay | IC50 = 10.26 μM | 21504204 | ||
| Bel7402 | Growth inhibition assay | IC50 = 10.31 μM | 29102175 | ||
| OVCAR3 | Cytotoxicity assay | TGI = 10.32 μM | 26590508 | ||
| SGC7901 | Cytotoxicity assay | IC50 = 10.37 μM | 20435479 | ||
| SNB75 | Cytotoxicity assay | TGI = 10.42 μM | 26590508 | ||
| A431 | Antiproliferative activity assay | IC50 = 10.46 μM | 29032031 | ||
| SMMC7721 | Antiproliferative activity assay | IC50 = 10.61 μM | 29032031 | ||
| GES-1 | Cytotoxicity assay | IC50 = 10.68 μM | 27162123 | ||
| H460 | Cytotoxicity assay | IC50 = 10.8 μM | 24300920 | ||
| BGC823 | Antiproliferative activity assay | IC50 = 10.91 μM | 22721924 | ||
| Hep3B | Cytotoxicity assay | IC50 = 11.2 μM | 28342400 | ||
| MCF7 | Cytotoxicity assay | IC50 = 11.34 μM | 27162123 | ||
| MCF7 | Cytotoxicity assay | IC50 = 11.34 μM | 23871909 | ||
| SK-MEL-2 | Antiproliferative activity human | IC50 = 11.35 μM | 28242553 | ||
| HepG2 | Cytotoxicity assay | IC50 = 11.49 μM | 21504204 | ||
| A375P | Antiproliferative activity assay | IC50 = 11.5 μM | 22014559 | ||
| SGC7901 | Cytotoxicity assay | IC50 = 11.5 μM | 24300920 | ||
| HeLa | Antiproliferative activity assay | IC50 = 12.01 μM | 29103873 | ||
| PANC1 | Cytotoxicity assay | IC50 = 12.3 μM | 24300920 | ||
| HepG2 | Antiproliferative activity assay | IC50 = 12.54 μM | 29032031 | ||
| A549 | Antiproliferative activity assay | IC50 = 12.54 μM | 23644219 | ||
| Caki1 | Growth inhibition assay | TGI = 12.59 μM | 28088086 | ||
| OVCAR8 | Growth inhibition assay | TGI = 12.59 μM | 28088086 | ||
| SKOV3 | Antiproliferative activity assay | TGI = 12.6 μM | 27017549 | ||
| ACHN | Antiproliferative activity assay | TGI = 12.6 μM | 27017549 | ||
| OVCAR3 | Antiproliferative activity assay | TGI = 12.6 μM | 27017549 | ||
| OVCAR4 | Antiproliferative activity assay | TGI = 12.6 μM | 27017549 | ||
| HCT15 | Antiproliferative activity assay | TGI = 12.6 μM | 27017549 | ||
| SW620 | Antiproliferative activity assay | TGI = 12.6 μM | 27017549 | ||
| A549/ATCC | Antiproliferative activity assay | TGI = 12.6 μM | 27017549 | ||
| MDA-MB-468 | Cytotoxicity assay | TGI = 13.09 μM | 26590508 | ||
| SK-MEL-28 | Cytotoxicity assay | TGI = 13.39 μM | 26590508 | ||
| A549 | Antiproliferative activity assay | IC50 = 13.64 μM | 26560049 | ||
| A375 | Antiproliferative activity human | IC50 = 13.64 μM | 28242553 | ||
| A375 | Antiproliferative activity assay | IC50 = 13.64 μM | 25462267 | ||
| K562 | Antiproliferative activity assay | IC50 = 13.85 μM | 23644219 | ||
| Hep3B | Cytotoxicity assay | IC50 = 14.08 μM | 21504204 | ||
| T47D | Cytotoxicity assay | TGI = 14.38 μM | 26590508 | ||
| NCI-H226 | Cytotoxicity assay | TGI = 14.42 μM | 26590508 | ||
| MDA-MB-231 | Antiproliferative activity assay | IC50 = 14.62 μM | 24440479 | ||
| MDA-MB-231 | Antiproliferative activity assay | IC50 = 14.62 μM | 23644219 | ||
| NCI-H522 | Cytotoxicity assay | TGI = 14.82 μM | 26590508 | ||
| SK-MEL-2 | Cytotoxicity assay | TGI = 14.85 μM | 26590508 | ||
| OS-RC2 | Cytotoxicity assay | IC50 = 15 μM | 29786436 | ||
| HepG2 | Antiproliferative activity assay | IC50 = 15 μM | 29103873 | ||
| fibroblast | Antiproliferative activity assay | IC50 = 15.1 μM | 18477505 | ||
| HT-29 | Cytotoxicity assay | IC50 = 15.2 μM | 24675135 | ||
| U87MG | Cytotoxicity assay | IC50 = 15.57 μM | 24826815 | ||
| BT549 | Antiproliferative activity assay | LC50 = 15.8 μM | 27017549 | ||
| GES-1 | Cytotoxicity assay | IC50 = 15.8 μM | 23871909 | ||
| SNB19 | Antiproliferative activity assay | TGI = 15.85 μM | 27017549 | ||
| IGROV1 | Antiproliferative activity assay | TGI = 15.9 μM | 27017549 | ||
| HCT116 | Antiproliferative activity assay | LC50 = 15.9 μM | 27017549 | ||
| OS-RC2 | Cytotoxicity assay | IC50 = 16 μM | 23454017 | ||
| A375 | Cytotoxicity assay | IC50 = 16.24 μM | 25461318 | ||
| SKOV3 | Cytotoxicity assay | TGI = 16.36 μM | 26590508 | ||
| WM1361 | Antiproliferative activity assay | IC50 = 16.44 μM | 29602674 | ||
| MKN28 | Antiproliferative activity assay | IC50 = 17 μM | 29032031 | ||
| SMMC7721 | Cytotoxicity assay | IC50 = 17.3 μM | 21504204 | ||
| UACC257 | Cytotoxicity assay | TGI = 17.33 μM | 26590508 | ||
| EAhy926 | Antiangiogenic activity assay | IC50 = 18.52 μM | 29032031 | ||
| SMMC7721 | Cytotoxicity assay | IC50 = 18.7 μM | 24300920 | ||
| Ketr3 | Cytotoxicity assay | IC50 = 18.8 μM | 24675135 | ||
| NCI-H522 | Cytotoxicity assay | IC50 = 19.26 μM | 25461318 | ||
| A549 | Cytotoxicity assay | IC50 = 19.54 μM | 27162123 | ||
| SH-SY5Y | Cytotoxicity assay | IC50 = 19.54 μM | 23871909 | ||
| MGC803 | Antiproliferative activity assay | IC50 = 19.92 μM | 29103873 | ||
| EKVX | Growth inhibition assay | TGI = 19.95 μM | 28088086 | ||
| OVCAR5 | Antiproliferative activity assay | TGI = 20 μM | 27017549 | ||
| UACC62 | Antiproliferative activity assay | LC50 = 20 μM | 27017549 | ||
| UACC257 | Antiproliferative activity assay | LC50 = 20 μM | 27017549 | ||
| MDA-MB-231 | Antiproliferative activity assay | LC50 = 20 μM | 27017549 | ||
| U87 | Cytotoxicity assay | IC50 = 21.07 μM | 20435479 | ||
| EJ | Cytotoxicity assay | IC50 = 22.9 μM | 24300920 | ||
| HCT116 | Antiproliferative activity assay | IC50 = 23.31 μM | 29602674 | ||
| HOP62 | Cytotoxicity assay | TGI = 23.55 μM | 26590508 | ||
| MDA-MB-231 | Cytotoxicity assay | TGI = 23.93 μM | 26590508 | ||
| PC3 | Antiproliferative activity assay | IC50 = 24.2 μM | 24440479 | ||
| PC3 | Antiproliferative activity assay | IC50 = 24.2 μM | 23644219 | ||
| EAhy926 | Antiproliferative activity assay | IC50 = 24.36 μM | 28068599 | ||
| EAhy926 | Anti-angiogenic activity in human | IC50 = 24.36 μM | 29102175 | ||
| U251 | Cytotoxicity assay | IC50 = 24.71 μM | 20435479 | ||
| NIH/3T3 | Antiproliferative activity assay | IC50 = 24.75 μM | 21592628 | ||
| NIH/3T3 | Antiproliferative activity assay | IC50 = 24.75 μM | 22647720 | ||
| DU145 | Cytotoxicity assay | IC50 = 24.91 μM | 27162123 | ||
| DU145 | Cytotoxicity assay | IC50 = 24.91 μM | 23871909 | ||
| U251 | Antiproliferative activity assay | LC50 = 25.1 μM | 27017549 | ||
| M14 | Antiproliferative activity assay | LC50 = 25.1 μM | 27017549 | ||
| NCI-H522 | Antiproliferative activity assay | LC50 = 25.1 μM | 27017549 | ||
| OVCAR4 | Growth inhibition assay | TGI = 25.12 μM | 28088086 | ||
| SH-SY5Y | Cytotoxicity assay | IC50 = 27.71 μM | 27162123 | ||
| A549 | Cytotoxicity assay | IC50 = 27.71 μM | 23871909 | ||
| PLC/PRF/5 | Cytotoxicity assay | IC50 = 29.9 μM | 28109948 | ||
| SK-MEL-5 | Cytotoxicity assay | TGI = 31.26 μM | 26590508 | ||
| A498 | Antiproliferative activity assay | LC50 = 31.6 μM | 27017549 | ||
| SK-MEL-28 | Antiproliferative activity assay | LC50 = 31.6 μM | 27017549 | ||
| KM12 | Antiproliferative activity assay | LC50 = 31.6 μM | 27017549 | ||
| COLO205 | Antiproliferative activity assay | LC50 = 31.6 μM | 27017549 | ||
| NCI-H226 | Antiproliferative activity assay | LC50 = 31.6 μM | 27017549 | ||
| SF295 | Antiproliferative activity assay | LC50 = 31.6 μM | 27017549 | ||
| HOP62 | Antiproliferative activity assay | LC50 = 31.6 μM | 27017549 | ||
| T47D | Antiproliferative activity assay | LC50 = 31.6 μM | 27017549 | ||
| MHCC97L | Cytotoxicity assay | IC50 = 34.41 μM | 28109948 | ||
| MDA-MB-231 | Antiproliferative activity assay | IC50 = 35 μM | 24315192 | ||
| MDA-MB-231 | Cytotoxicity assay | IC50 = 36 μM | 22483592 | ||
| B16-BL6 | Cytotoxicity assay | IC50 = 36.48 μM | 29631788 | ||
| UO31 | Antiproliferative activity assay | LC50 = 39.8 μM | 27017549 | ||
| SN12C | Antiproliferative activity assay | LC50 = 39.8 μM | 27017549 | ||
| RXF393 | Antiproliferative activity assay | LC50 = 39.8 μM | 27017549 | ||
| SNB75 | Antiproliferative activity assay | LC50 = 39.8 μM | 27017549 | ||
| SF268 | Antiproliferative activity assay | LC50 = 39.8 μM | 27017549 | ||
| NCI-H23 | Antiproliferative activity assay | LC50 = 39.8 μM | 27017549 | ||
| HT-29 | Antiproliferative activity assay | LC50 = 39.8 μM | 27017549 | ||
| HOP92 | Antiproliferative activity assay | LC50 = 39.8 μM | 27017549 | ||
| NCI-H460 | Antiproliferative activity assay | LC50 = 39.8 μM | 27017549 | ||
| SW620 | Antiproliferative activity assay | LC50 = 39.8 μM | 27017549 | ||
| MDA-MB-468 | Antiproliferative activity assay | LC50 = 39.8 μM | 27017549 | ||
| MALME-3M | Growth inhibition assay | TGI = 39.81 μM | 28088086 | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Sorafenib是Raf-1和B-Raf的多重激酶抑制剂，无细胞试验中IC50分别为6 nM和22 nM。Sorafenib 还可抑制VEGFR-2、VEGFR-3、PDGFR-β、Flt-3和c-KIT，对应的IC50值分别为90 nM、20 nM、57 nM、59 nM和68 nM。Sorafenib 可诱导autophagy、apoptosis并激活ferroptosis，Sorafenib 具有抗肿瘤活性。 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶点 |
|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | Sorafenib抑制野生型和V599E突变型B-Raf活性，IC50分别为22 nM 和 38 nM。Sorafenib也能有效抑制mVEGFR2 (Flk-1)，mVEGFR3，mPDGFRβ，Flt3，和c-Kit，IC50分别为15 nM，20 nM，57 nM，58 nM，和68 nM。Sorafenib 能够较弱地抑制FGFR-1，IC50 为580 nM。Sorafenib对ERK-1，MEK-1，EGFR，HER-2，IGFR-1，c-Met，PKB，PKA，cdk1/cyclinB，PKCα，PKCγ，和pim-1没有活性。Sorafenib显著抑制NIH 3T3细胞中VEGFR2磷酸化，IC50 为 30 nM，也会抑制HEK-293细胞中Flt-3磷酸化，IC50 为20 nM。Sorafenib有效阻断大多数细胞中MEK 1/2 和 ERK 1/2磷酸化，但不阻断A549 或 H460细胞中该过程，同时不影响PKB通路的抑制。Sorafenib抑制HAoSMC 和 MDA-MB-231细胞的增殖，IC50分别为0.28 μM 和 2.6 μM。[1]除了抑制RAF/MEK/ERK信号通路，Sorafenib tosylate显著抑制eIF4E的磷酸化作用，并以MEK/ERK依赖的方式下调肝癌(HCC)细胞中Mcl-1水平。Sorafenib 抑制PLC/PRF/5 和HepG2细胞的增殖，IC50分别为6.3 μM 和 4.5 μM，并诱导显著的细胞凋亡。[2] | |||
|---|---|---|---|---|
| 激酶实验 | 生化检测 | |||
| 重组杆状病毒表达的Raf-1 (残基305–648)和 B-Raf (残基 409–765)以融合蛋白纯化。全长人MEK-1由PCR产生，并以大肠杆菌裂解物中的融合蛋白纯化。将Sorafenib加入到含Raf-1 (80纳克)，或B-Raf (80 纳克) 以及MEK-1 (1 微克) 混合物的实验缓冲液[20 mM Tris (pH 8.2)，100 mM NaCl，5 mM MgCl2，和0.15% β-巯基乙醇]中，DMSO终浓度为1%。加入25微升10 μM γ[33P]ATP (400 Ci/mol)启动Raf激酶试验(终体积50微升)，并在32 °C下培育25分钟。磷酸化的MEK-1通过过滤到磷酸纤维素板上采集，使用1%磷酸洗掉未结合的放射性。微波炉加热干燥后，使用β型板计数器量化过滤器结合放射性。人VEGFR2 (KDR)激酶域被表达，并从Sf9裂解物中纯化。VEGFR2的时间分辨荧光分析法能量转移测试在96孔不透明板中以时间分辨荧光分析法能量转移格式进行。最终反应条件如下：1 到10 μM ATP，25 nM poly GT生物素，2 nM 铕标记的磷酸(p)-酪氨酸抗体(PY20)，10 nM APC，1% DMSO 终浓度的1 到 7 nM 细胞质激酶域，50 mM HEPES (pH 7.5)，10 mM MgCl2，0.1 mM EDTA，0.015% Brij-35，0.1 毫克/毫升BSA，和0.1% β-巯基乙醇。反应体积为100微升，加入酶启动反应。反应启动~1.5 到 2.0小时后，板以615 和 665 nM在Perkin-Elmer VictorV多标记分析仪上读数。信号按如下比率计算：对每孔(665 nm/615 nM) × 10,000。对IC50的产生，在酶起始反应之前加入Sorafenib。50倍的库存板由Sorafenib在50% DMSO/50%蒸馏水溶液中连续稀释制得。最终Sorafenib在1% DMSO中的浓度范围为10 μM 到 4.56 nM。 | ||||
| 细胞实验 | 细胞系 | MDA-MB-231，和 HAoSMC | ||
| 浓度 | 溶解于DMSO，终浓度为~10 μM | |||
| 孵育时间 | 72小时 | |||
| 方法 | 细胞在逐渐增加浓度的Sorafenib下暴露72小时。细胞数通过Cell TiterGlo ATP发光测定试剂盒进行定量。该试验通过测定基于细胞中ATP量的发光信号，测量每孔中的活细胞。 | |||
| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western blot | LC3-I / LC-3II / ATG5 p-STAT3 / STAT3 / Mcl-1 β-catenin / Survivin / Mcl-1 / PTMA pERK / ERK p-PKM2(y105) / PMK2 / Caspase-9 RET(pY1016) / VEGFR2(pY1214) / MEK1(pT292) / ERK(pY204) Cyclin D1 |
|
23392173 | |
| Growth inhibition assay | Cell viability |
|
26039995 | |
| Immunofluorescence | p65 cytochrome c |
|
22286758 | |
| ELISA | TGF-beta / CD206 Caspase-9 / Caspase-3 |
|
26158762 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 | Sorafenib(~60 mg/kg)口服给药，对各种人肿瘤异种移植模型，包括MDA-MB-231，Colo-205，HT-29，DLD-1，NCI-H460，和A549表现出广谱的、剂量依赖性抗肿瘤活性，而没有毒性。与抗肿瘤功效相联系，Sorafenib 治疗有效抑制HT-29 和 MDA-MB-231异种移植物中MEK 1/2磷酸化和pERK 1/2水平，但对Colo-205异种移植物没有作用，并且也能显著抑制MDA MB-231，HT-29 和 Colo-205肿瘤异种移植物中肿瘤微血管面积(MVA)和微血管密度(MVD)。[1] 在SCID小鼠体内，Sorafenib治疗对PLC/PRF/5肿瘤异种移植产生剂量依赖性生长抑制，10 mg/kg和30 mg/kg剂量下，TGIs分别为49%和78%，与ERK 和 eIF4E磷酸化抑制，微血管面积减少，和肿瘤细胞凋亡的诱导相一致。[2] Sorafenib通过下调NF-κB介导的Mcl-1 和 cIAP2表达的作用机制使bax-/-细胞对TRAIL剂量依赖性敏感。 Sorafenib (30-60 mg/kg) 与 TRAIL (5 mg/kg)结合对TRAIL抗性HCT116 bax-/-和HT29肿瘤异种移植物表现出显著的功效。[3] | |
|---|---|---|
| 动物实验 | Animal Models | 雌性 NCr-nu/nu 小鼠，皮下植入MDA-MB-231，Colo-205，HT-29，H460，或 A549 细胞 |
| Dosages | ~60 mg/kg | |
| Administration | 口服，每天一次 | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05068752 | Recruiting | Pancreas Cancer |
HonorHealth Research Institute|Bayer|Genentech Inc. |
October 28 2021 | Phase 2 |
| NCT04763408 | Recruiting | Carcinoma Hepatocellular |
Eisai Inc. |
April 9 2021 | -- |
| NCT04000737 | Recruiting | Advanced Hepatocellular Carcinoma |
Yiviva Inc. |
January 10 2020 | Phase 2 |
化学信息&溶解度
| 分子量 | 464.82 | 分子式 | C21H16ClF3N4O3 |
| CAS号 | 284461-73-0 | SDF | Download Sorafenib SDF |
| Smiles | CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
DMSO : 93 mg/mL ( (200.07 mM)； DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Water : Insoluble Ethanol : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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