DYRK
抑制剂选择性比较
DYRK产品
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7338 |
AZ191AZ191是一种有效的选择性DYRK1B抑制剂，无细胞试验中IC50为17 nM，比作用于DYRK1A 和 DYRK2选择性分别高5和110倍。 |
In (e), quiescent cells were left untreated or treated for 30 min with 10 nM R1881, in the absence or presence of the DYRK 1B inhibitor AZ191, which was added (1 μM) 15 min before hormonal stimulation. Control cells in right panel were treated with the inhibitor alone. In left panels, lysate proteins were immunoprecipitated with anti-DYRK 1B antibody. Immune complexes were analyzed for DYRK 1B activity using MBP as a substrate. DYRK 1B levels in immune complexes were detected by immunoblot with anti-DYRK 1B antibody. In right panels, lysate proteins were analyzed by western blot, using antibodies against the indicated proteins. |
|
| S7327 |
ID-8ID-8能够在长期培养中维持胚胎干细胞自我更新。 |
||
| S3817 |
Harmine hydrochlorideHarmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. It can also inhibit monoamine oxidases (MAOs) and cdc-like kinases (CLKs). |
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7338 |
AZ191AZ191是一种有效的选择性DYRK1B抑制剂，无细胞试验中IC50为17 nM，比作用于DYRK1A 和 DYRK2选择性分别高5和110倍。 |
In (e), quiescent cells were left untreated or treated for 30 min with 10 nM R1881, in the absence or presence of the DYRK 1B inhibitor AZ191, which was added (1 μM) 15 min before hormonal stimulation. Control cells in right panel were treated with the inhibitor alone. In left panels, lysate proteins were immunoprecipitated with anti-DYRK 1B antibody. Immune complexes were analyzed for DYRK 1B activity using MBP as a substrate. DYRK 1B levels in immune complexes were detected by immunoblot with anti-DYRK 1B antibody. In right panels, lysate proteins were analyzed by western blot, using antibodies against the indicated proteins. |
|
| S7327 |
ID-8ID-8能够在长期培养中维持胚胎干细胞自我更新。 |
||
| S3817 |
Harmine hydrochlorideHarmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. It can also inhibit monoamine oxidases (MAOs) and cdc-like kinases (CLKs). |
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