DYRK
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S7338 | AZ191 | <1 mg/mL | 85 mg/mL | 1 mg/mL |
| S7327 | ID-8 | <1 mg/mL | 60 mg/mL | 2 mg/mL |
| S3817 | Harmine hydrochloride | 21 mg/mL | 21 mg/mL | -1 mg/mL |
- DYRK抑制剂（3）
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7338 |
AZ191AZ191是一种有效的选择性DYRK1B抑制剂，无细胞试验中IC50为17 nM，比作用于DYRK1A 和 DYRK2选择性分别高5和110倍。 |
(E) BEL7402 and HepG2 cells were treated with vehicle or 10 μM of the DYRK1B inhibitor, AZ191, alone and in combination with BafA1 for 24 h. Cyclin D1 expression was examined by immunoblot analysis.
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| S7327 |
ID-8ID-8能够在长期培养中维持胚胎干细胞自我更新。 |
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| S3817 |
Harmine hydrochlorideHarmine, a fluorescent harmala alkaloid belonging to the beta-carboline family of compounds, is a highly cell-permeant and competitive inhibitor of ATP binding to the kinase pocket of DYRK1A, with about 60-fold higher IC50 value for DYRK2. It can also inhibit monoamine oxidases (MAOs) and cdc-like kinases (CLKs). |
