DYRK
抑制剂选择性比较
DYRK产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S7338 |
AZ191AZ191是一种有效的选择性DYRK1B抑制剂,无细胞试验中IC50为17 nM,比作用于DYRK1A 和 DYRK2选择性分别高5和110倍。 |
![]() ![]() In (e), quiescent cells were left untreated or treated for 30 min with 10 nM R1881, in the absence or presence of the DYRK 1B inhibitor AZ191, which was added (1 μM) 15 min before hormonal stimulation. Control cells in right panel were treated with the inhibitor alone. In left panels, lysate proteins were immunoprecipitated with anti-DYRK 1B antibody. Immune complexes were analyzed for DYRK 1B activity using MBP as a substrate. DYRK 1B levels in immune complexes were detected by immunoblot with anti-DYRK 1B antibody. In right panels, lysate proteins were analyzed by western blot, using antibodies against the indicated proteins. |
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S7327 |
ID-8ID-8能够在长期培养中维持胚胎干细胞自我更新。 |
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S3817 |
Harmine hydrochlorideHarmine (Telepathine)是属于β-咔啉家族化合物的一种荧光harmala生物碱,是一种高细胞渗透性的 DYRK1A 的激酶口袋结合ATP的竞争性抑制剂,与DYRK2结合IC50值高约60倍。Harmine 还可以抑制 monoamine oxidases (MAOs) 和 cdc-like kinases (CLKs)。Harmine 抑制 5-HT2A serotonin receptor 的Ki值为397 nM。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S7338 |
AZ191AZ191是一种有效的选择性DYRK1B抑制剂,无细胞试验中IC50为17 nM,比作用于DYRK1A 和 DYRK2选择性分别高5和110倍。 |
![]() ![]() In (e), quiescent cells were left untreated or treated for 30 min with 10 nM R1881, in the absence or presence of the DYRK 1B inhibitor AZ191, which was added (1 μM) 15 min before hormonal stimulation. Control cells in right panel were treated with the inhibitor alone. In left panels, lysate proteins were immunoprecipitated with anti-DYRK 1B antibody. Immune complexes were analyzed for DYRK 1B activity using MBP as a substrate. DYRK 1B levels in immune complexes were detected by immunoblot with anti-DYRK 1B antibody. In right panels, lysate proteins were analyzed by western blot, using antibodies against the indicated proteins. |
|
S7327 |
ID-8ID-8能够在长期培养中维持胚胎干细胞自我更新。 |
||
S3817 |
Harmine hydrochlorideHarmine (Telepathine)是属于β-咔啉家族化合物的一种荧光harmala生物碱,是一种高细胞渗透性的 DYRK1A 的激酶口袋结合ATP的竞争性抑制剂,与DYRK2结合IC50值高约60倍。Harmine 还可以抑制 monoamine oxidases (MAOs) 和 cdc-like kinases (CLKs)。Harmine 抑制 5-HT2A serotonin receptor 的Ki值为397 nM。 |