Glutaminase

所有产品 Glutaminase抑制剂(4) 新Glutaminase产品

产品目录	产品描述	文献引用	实验数据
S7655	CB-839 CB-839 是一种有效的，选择性的，口服生物可利用的 glutaminase 抑制剂，对重组人GAC的 IC50 为 24 nM。Phase 1。	Br J Cancer, 2018, 118(8):1074-1083 Biochem Pharmacol, 2018, 156:204-214 Tumour Biol, 2016, 37(8):11007-15	Apoptotic sensitivity of K562 resistant (E) cells exposed to A1331852 (10 nM) for 4 h was restored following pharmacological inhibition of glutamine uptake or metabolism with GPNA (5 mM) for 48 h, CB-839 (10 μM) for 72 h, azaserine (25 μM) for 16 h and AOA (500 μM) for 24 h but not with EGCG (50 μM) for 24 h. Western blots confirmed the knockdown efficiency of the different siRNAs. *P<0.001, P<0.01; Error bars = Mean ± SEM (n=3).
S7753	BPTES BPTES是一种有效的选择性Glutaminase GLS1 (KGA)抑制剂，其IC50为0.16 μM。它对谷氨酸脱氢酶的活性没有影响，对γ谷氨酰转肽酶的活性只有很微弱的抑制作用。	J Cancer, 2018, 9(9):1582-1591 Onco Targets Ther, 2018, 11:3721-3729	Glu-dependent associates with sensitivity to glycolytic inhibitors 3-BrPA (left) and GLN-addicted associates with sensitivity to glutaminolytic inhibitors BPTEs.
S8778^New	UPGL00004 UPGL00004是有效的glutaminase C (GAC)抑制剂，IC50为29 nM，对GAC比对GLS2更具有选择性。
S6417^New	GK921 GK921是transglutaminase 2 (TGase 2)抑制剂，IC50为8.93 μM。

产品目录	产品描述	文献引用	实验数据
S7655	CB-839 CB-839 是一种有效的，选择性的，口服生物可利用的 glutaminase 抑制剂，对重组人GAC的 IC50 为 24 nM。Phase 1。	Br J Cancer,2018, 118(8):1074-1083 Biochem Pharmacol,2018, 156:204-214 Tumour Biol,2016, 37(8):11007-15	Apoptotic sensitivity of K562 resistant (E) cells exposed to A1331852 (10 nM) for 4 h was restored following pharmacological inhibition of glutamine uptake or metabolism with GPNA (5 mM) for 48 h, CB-839 (10 μM) for 72 h, azaserine (25 μM) for 16 h and AOA (500 μM) for 24 h but not with EGCG (50 μM) for 24 h. Western blots confirmed the knockdown efficiency of the different siRNAs. *P<0.001, P<0.01; Error bars = Mean ± SEM (n=3).
S7753	BPTES BPTES是一种有效的选择性Glutaminase GLS1 (KGA)抑制剂，其IC50为0.16 μM。它对谷氨酸脱氢酶的活性没有影响，对γ谷氨酰转肽酶的活性只有很微弱的抑制作用。	J Cancer,2018, 9(9):1582-1591 Onco Targets Ther,2018, 11:3721-3729	Glu-dependent associates with sensitivity to glycolytic inhibitors 3-BrPA (left) and GLN-addicted associates with sensitivity to glutaminolytic inhibitors BPTEs.
S8778^New	UPGL00004 UPGL00004是有效的glutaminase C (GAC)抑制剂，IC50为29 nM，对GAC比对GLS2更具有选择性。
S6417^New	GK921 GK921是transglutaminase 2 (TGase 2)抑制剂，IC50为8.93 μM。