Glutaminase
- Glutaminase抑制剂（2）
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7655 |
CB-839CB-839 是一种有效的，选择性的，口服生物可利用的 glutaminase 抑制剂，对重组人GAC的 IC50 为 24 nM。Phase 1。 |
c. Indicated cell lines were treated with 0, 20 or 200 nM CB-839 in the presence or absence of FBS. In the absence of FBS, all cell lines are more sensitive for inhibition with CB-839, especially the IDH1/2 mutant cell lines.
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| S7753 |
BPTESBPTES是一种有效的选择性Glutaminase GLS1 (KGA)抑制剂，其IC50为0.16 μM。它对谷氨酸脱氢酶的活性没有影响，对γ谷氨酰转肽酶的活性只有很微弱的抑制作用。 |
Glu-dependent associates with sensitivity to glycolytic inhibitors 3-BrPA (left) and GLN-addicted associates with sensitivity to glutaminolytic inhibitors BPTEs.
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