OX Receptor
信号通路图
研究领域
抑制剂选择性比较
特异性亚型抑制剂
OX Receptor产品
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7585 |
SB-334867SB-334867 是一种选择性 orexin-1 (OX1) receptor 拮抗剂。 |
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| S1545 |
SB408124SB408124是一种非肽类OX1 receptor拮抗剂，作用于全细胞和膜，Ki分别为57 nM和27 nM，比作用于OX2受体选择性高50倍。 |
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| S6726New |
MK1064MK1064是选择性orexin 2 receptor拮抗剂，IC50为18 nM。 |
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| S2160 |
Almorexant HClAlmorexant HCl 是口服有效的双重orexin receptor 拮抗剂，其作用于受体 OX1 和 OX2 的 IC50 分别为 6.6 nM 和 3.4 nM。 |
(C) No significant changes were observed compared with PBS control (n = 5) when sSNA is measured as % range. Grouped data for the % range from every treatment group are compared. AXT at 75 mg/kg (n = 4) produced no effect on baseline sympathetic activity. (D) AXT at 30 mg/kg (n = 5) and 75 mg/kg (n = 5) attenuated the effect of intermittent orexin-A (10 pmol×10; n = 5) on sSNA. Statistical significance was determined using one-way analysis of variance followed by Holm-Sidak correction to compare the effects with the control. Data are expressed as mean±S.E.M. ****P<0.0001; ***P<0.001; *P <0.05. #P<0.05 compared with intermittent orexin-A (10 pmol×10).
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| S6717New |
TCS-OX2-29TCX-OX2-29是OX2R 拮抗剂，pKi=7.5。对hOX2R的选择性比hOX1R高250倍以上，IC50分别为40 nM和>10000 nM。 |
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7585 |
SB-334867SB-334867 是一种选择性 orexin-1 (OX1) receptor 拮抗剂。 |
||
| S1545 |
SB408124SB408124是一种非肽类OX1 receptor拮抗剂，作用于全细胞和膜，Ki分别为57 nM和27 nM，比作用于OX2受体选择性高50倍。 |
||
| S6726New |
MK1064MK1064是选择性orexin 2 receptor拮抗剂，IC50为18 nM。 |
||
| S2160 |
Almorexant HClAlmorexant HCl 是口服有效的双重orexin receptor 拮抗剂，其作用于受体 OX1 和 OX2 的 IC50 分别为 6.6 nM 和 3.4 nM。 |
(C) No significant changes were observed compared with PBS control (n = 5) when sSNA is measured as % range. Grouped data for the % range from every treatment group are compared. AXT at 75 mg/kg (n = 4) produced no effect on baseline sympathetic activity. (D) AXT at 30 mg/kg (n = 5) and 75 mg/kg (n = 5) attenuated the effect of intermittent orexin-A (10 pmol×10; n = 5) on sSNA. Statistical significance was determined using one-way analysis of variance followed by Holm-Sidak correction to compare the effects with the control. Data are expressed as mean±S.E.M. ****P<0.0001; ***P<0.001; *P <0.05. #P<0.05 compared with intermittent orexin-A (10 pmol×10).
|
|
| S6717New |
TCS-OX2-29TCX-OX2-29是OX2R 拮抗剂，pKi=7.5。对hOX2R的选择性比hOX1R高250倍以上，IC50分别为40 nM和>10000 nM。 |
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