OX Receptor
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S7585 | SB-334867 | <1 mg/mL | 63 mg/mL | 3 mg/mL |
| S1545 | SB408124 | <1 mg/mL | 36 mg/mL | <1 mg/mL |
| S2160 | Almorexant HCl | <1 mg/mL | 72 mg/mL | 51 mg/mL |
| S3054 | Alverine Citrate | <1 mg/mL | 95 mg/mL | <1 mg/mL |
| S3880 | Schisantherin A | -1 mg/mL | 100 mg/mL | -1 mg/mL |
特异性亚型抑制剂
- OX Receptor抑制剂（5）
- 新OX Receptor产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7585 |
SB-334867SB-334867 是一种选择性 orexin-1 (OX1) receptor 拮抗剂。 |
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| S1545 |
SB408124SB408124是一种非肽类OX1 receptor拮抗剂，作用于全细胞和膜，Ki分别为57 nM和27 nM，比作用于OX2受体选择性高50倍。 |
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| S2160 |
Almorexant HClAlmorexant HCl 是口服有效的双重orexin receptor 拮抗剂，其作用于受体 OX1 和 OX2 的 IC50 分别为 6.6 nM 和 3.4 nM。 |
(C) No significant changes were observed compared with PBS control (n = 5) when sSNA is measured as % range. Grouped data for the % range from every treatment group are compared. AXT at 75 mg/kg (n = 4) produced no effect on baseline sympathetic activity. (D) AXT at 30 mg/kg (n = 5) and 75 mg/kg (n = 5) attenuated the effect of intermittent orexin-A (10 pmol×10; n = 5) on sSNA. Statistical significance was determined using one-way analysis of variance followed by Holm-Sidak correction to compare the effects with the control. Data are expressed as mean±S.E.M. ****P<0.0001; ***P<0.001; *P <0.05. #P<0.05 compared with intermittent orexin-A (10 pmol×10).
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| S3054 |
Alverine CitrateAlverine citrate是一种治疗功能性肠胃病的药物。 |
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| S3880New |
Schisantherin ASchisantherin A，也被称作Gomisin C，是一种五味子红素，具有止咳、镇静、消炎、抗骨质疏松、神经保护、增强认知和心脏保护活性。 |
