PDHK
抑制剂选择性比较
PDHK产品
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7517 |
AZD7545AZD7545是有效的PDHK抑制剂，对PDHK1和PDHK2的IC50分别为36.8 nM和6.4 nM。在高浓度下不能抑制PDHK4，其能刺激PDHK4活性。 |
AZD7545 mediated growth suppression of BRAFV600E mutant and NRASmut melanoma cells. Twenty-four hours after plating, both A375 and IGR37 cell lines (BRAFV600E) (a) and SKMel30, IPC298 and MelJuso cell lines (NRASmut) (b) were treated with 10 μM of AZD7545. The plates were imaged using an IncuCyte ZOOM live cell microscope (Essen BioScience) and images were taken every 3 h for a total of 90 h (BRAFV600E) and 120 h (NRASmut). Results are shown for one representative of three biological replicates
|
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7517 |
AZD7545AZD7545是有效的PDHK抑制剂，对PDHK1和PDHK2的IC50分别为36.8 nM和6.4 nM。在高浓度下不能抑制PDHK4，其能刺激PDHK4活性。 |
AZD7545 mediated growth suppression of BRAFV600E mutant and NRASmut melanoma cells. Twenty-four hours after plating, both A375 and IGR37 cell lines (BRAFV600E) (a) and SKMel30, IPC298 and MelJuso cell lines (NRASmut) (b) were treated with 10 μM of AZD7545. The plates were imaged using an IncuCyte ZOOM live cell microscope (Essen BioScience) and images were taken every 3 h for a total of 90 h (BRAFV600E) and 120 h (NRASmut). Results are shown for one representative of three biological replicates
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