PTEN

抑制剂选择性比较

PTEN产品

目录号 产品描述 文献引用 实验数据
S7310

SF1670

SF1670是一种高度有效且专一的PTEN的抑制剂,其IC50 为 2 μM。

S8651

bpV (HOpic)

bpV (HOpic)是一种有效的PTEN抑制剂,IC50为14 nM。它对PTP-β和PTP-1B的IC50值分别约是对PTEN的IC50的350倍和1800倍。

S8174

VO-Ohpic trihydrate

VO-Ohpic是一种有效的PTEN (phosphatase and tensin homolog)抑制剂,IC50为35 nM。

S9190

Oroxin B

Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.

S0918New

Ginkgolic acid C17:1

Ginkgolic acid (C17:1) suppresses constitutive and inducible STAT3 activation through induction of PTEN and SHP-1 tyrosine phosphatase. Ginkgolic acid (C17:1) is extracted from Ginkgo biloba Leaves, Ginkgolic acid (C17:1) exhibits anticancer effects.

目录号 产品描述 文献引用 实验数据
S7310

SF1670

SF1670是一种高度有效且专一的PTEN的抑制剂,其IC50 为 2 μM。

S8651

bpV (HOpic)

bpV (HOpic)是一种有效的PTEN抑制剂,IC50为14 nM。它对PTP-β和PTP-1B的IC50值分别约是对PTEN的IC50的350倍和1800倍。

S8174

VO-Ohpic trihydrate

VO-Ohpic是一种有效的PTEN (phosphatase and tensin homolog)抑制剂,IC50为35 nM。

目录号 产品描述 文献引用 实验数据
S9190

Oroxin B

Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.

S0918New

Ginkgolic acid C17:1

Ginkgolic acid (C17:1) suppresses constitutive and inducible STAT3 activation through induction of PTEN and SHP-1 tyrosine phosphatase. Ginkgolic acid (C17:1) is extracted from Ginkgo biloba Leaves, Ginkgolic acid (C17:1) exhibits anticancer effects.