PTEN

抑制剂选择性比较

PTEN产品

目录号 产品描述 文献引用 实验数据
S7310

SF1670

SF1670是一种高度有效且专一的PTEN的抑制剂，其IC50 为 2 μM。

Cell Mol Immunol, 2020, 10.1038/s41423-020-0363-5
Aging (Albany NY), 2020, 13;12(7):6352-6369
Biochem Pharmacol, 2020, 171:113674
S8651

bpV (HOpic)

bpV (HOpic)是一种有效的PTEN抑制剂，IC50为14 nM。它对PTP-β和PTP-1B的IC50值分别约是对PTEN的IC50的350倍和1800倍。
J Cell Mol Med, 2020, 24(1):61-78
J Diabetes Res, 2020, 31;2020:9481720
Eur J Pharmacol, 2019, 854:298-306
S8174

VO-Ohpic trihydrate

VO-Ohpic是一种有效的PTEN (phosphatase and tensin homolog)抑制剂，IC50为35 nM。
Aging (Albany NY), 2020, 24;12(2):1213-1236
Life Sci, 2020, 25;253:117718
Stem Cell Res Ther, 2020, 11(1):140
S9190

Oroxin B

Oroxin B, one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels is found to be downregulated, while PTEN was upregulated after Oroxin B treatment.
目录号 产品描述 文献引用 实验数据
S7310

SF1670

SF1670是一种高度有效且专一的PTEN的抑制剂，其IC50 为 2 μM。

Cell Mol Immunol,2020, 10.1038/s41423-020-0363-5
Aging (Albany NY),2020, 13;12(7):6352-6369
Biochem Pharmacol,2020, 171:113674
S8651

bpV (HOpic)

bpV (HOpic)是一种有效的PTEN抑制剂，IC50为14 nM。它对PTP-β和PTP-1B的IC50值分别约是对PTEN的IC50的350倍和1800倍。
J Cell Mol Med,2020, 24(1):61-78
J Diabetes Res,2020, 31;2020:9481720
Eur J Pharmacol,2019, 854:298-306
S8174

VO-Ohpic trihydrate

VO-Ohpic是一种有效的PTEN (phosphatase and tensin homolog)抑制剂，IC50为35 nM。
Aging (Albany NY),2020, 24;12(2):1213-1236
Life Sci,2020, 25;253:117718
Stem Cell Res Ther,2020, 11(1):140
目录号 产品描述 文献引用 实验数据
S9190

Oroxin B

Oroxin B, one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels is found to be downregulated, while PTEN was upregulated after Oroxin B treatment.