PTEN

PTEN产品

目录号	产品描述	文献引用	实验数据
S7310	SF1670 SF1670是一种高度有效且专一的PTEN的抑制剂，其IC50 为 2 μM。	J Cancer, 2021, 12(7):2140-2150 Elife, 2020, 9e55676 Elife, 2020, 9e55676	A、total of 1.5 μM PTEN inhibitor SF1670 inhibited the expression of PTEN and decreased the level of CD11b
S8651	bpV (HOpic) bpV (HOpic) (Bisperoxovanadium (HOpic))是一种有效的PTEN抑制剂，IC50为14 nM。它对PTP-β和PTP-1B的IC50值分别约是对PTEN的IC50的350倍和1800倍。	Int J Mol Sci, 2021, 22(12)6570 Front Cell Dev Biol, 2020, 8:587 J Cell Mol Med, 2020, 24(1):61-78
S8174	VO-Ohpic trihydrate VO-Ohpic是一种有效的PTEN (phosphatase and tensin homolog)抑制剂，IC50为35 nM。	Aging (Albany NY), 2020, 24;12(2):1213-1236 Life Sci, 2020, 25;253:117718 Eur Rev Med Pharmacol Sci, 2020, 24(6):2811-2819
S9190	Oroxin B Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.	J Cancer, 2021, 12(7):2140-2150
S0918	Ginkgolic acid C17:1 Ginkgolic acid C17:1 (GAC 17:1) 通过废除上游的 JAK2 和 Src 来抑制 STAT3 的组成性激活。Ginkgolic acid C17:1 可以诱导 PTEN 和 SHP-1 的大量表达。Ginkgolic acid C17:1 诱导肿瘤细胞凋亡。

目录号	产品描述	文献引用	实验数据
S7310	SF1670 SF1670是一种高度有效且专一的PTEN的抑制剂，其IC50 为 2 μM。	J Cancer,2021, 12(7):2140-2150 Elife,2020, 9e55676 Elife,2020, 9e55676	A、total of 1.5 μM PTEN inhibitor SF1670 inhibited the expression of PTEN and decreased the level of CD11b
S8651	bpV (HOpic) bpV (HOpic) (Bisperoxovanadium (HOpic))是一种有效的PTEN抑制剂，IC50为14 nM。它对PTP-β和PTP-1B的IC50值分别约是对PTEN的IC50的350倍和1800倍。	Int J Mol Sci,2021, 22(12)6570 Front Cell Dev Biol,2020, 8:587 J Cell Mol Med,2020, 24(1):61-78
S8174	VO-Ohpic trihydrate VO-Ohpic是一种有效的PTEN (phosphatase and tensin homolog)抑制剂，IC50为35 nM。	Aging (Albany NY),2020, 24;12(2):1213-1236 Life Sci,2020, 25;253:117718 Eur Rev Med Pharmacol Sci,2020, 24(6):2811-2819

目录号	产品描述	文献引用	实验数据
S9190	Oroxin B Oroxin B (Hypocretin-2), one of flavonoids isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent, selectively induces tumor-suppressive ER stress in malignant lymphoma cells and has antioxidant activity. Oroxin B significantly inhibits proliferation and induce apoptosis, which may be strongly associated with the inhibiting COX-2/VEGF and PTEN/PI3K/AKT signaling pathway in SMMC-7721 cells, Oroxin B potentially be used as a novel therapeutic agent for liver cancer.COX-2, VEGF, PI3K, and p-AKT expression levels are downregulated, while PTEN is upregulated after Oroxin B treatment.	J Cancer, 2021, 12(7):2140-2150
S0918	Ginkgolic acid C17:1 Ginkgolic acid C17:1 (GAC 17:1) 通过废除上游的 JAK2 和 Src 来抑制 STAT3 的组成性激活。Ginkgolic acid C17:1 可以诱导 PTEN 和 SHP-1 的大量表达。Ginkgolic acid C17:1 诱导肿瘤细胞凋亡。