HDAC4 Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human | ||
| MW (kDa) | 140kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | HDAC4 Rabbit Recombinant mAb detects endogenous levels of total HDAC4. |
|---|---|
| 背景 | The acetylation and deacetylation of histones play an important role in the regulation of gene transcriptions. Histone acetylation is mediated by histone acetyltransferase, resulting in modification of the structure of chromatin, nucleosomal relaxation and altered transcriptional activation. The reverse reaction is mediated by histone deacetylase (HDAC), which induces deacetylation, chromatin condensation, and transcriptional repression. HDACs are divided into three distinct classes, I, II, and III. HDAC4 belongs to class II HDAC. HDAC4 is not expressed in the nuclei of mouse embryonic stem cells, but is dramatically up-regulated upon differentiation. HDAC4 shuttles between the nucleus and cytoplasm, and serves as a nuclear corepressor that regulates bone and muscle development. The activity of HDAC4 is regulated through subcellular localization and the formation of multi-subunit complexes with other proteins. |
实验方法
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