iNOS Rabbit Recombinant mAb
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使用信息
| 抗体应用 | wb,ELISA | ||
|---|---|---|---|
| 稀释比例 |
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| 反应性 | Human Mouse | ||
| MW (kDa) | 131kDa | ||
| 抗体类型 | Rabbit | ||
| 浓度 | 1mg/ml | ||
| 储存液配方 | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. | ||
| 储存条件 (自收到货起) |
Store at –20°C. |
生物描述
| 特异性 | iNOS Rabbit Recombinant mAb detects endogenous levels of total iNOS. |
|---|---|
| 背景 | Nitric oxide synthases (NOS) can be categorised into calcium dependent constitutive isoforms (endothelial NOS (eNOS) and neuronal NOS (nNOS)) and the calcium independent inducible isoform (iNOS), which is produced by a variety of mammalian cells as a result of cytokine and/or bacterial endotoxin stimulation. eNOS and nNOS only produce nanomolar concentrations of NO for seconds or minutes when activated. However, iNOS the inducible isoform generates higher amounts of NO, in the micromolar range and for longer intervals such as for hours or days. Thus, the expression levels of iNOS in tissues is a measure of NO generated in that tissue or its surrounding environment. iNOS overexpression produces pro-tumor or anti-tumor effects on tumor growth, depending on the tumor microenvironment and the tumor type in animal models. |
实验方法
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