BMI-1
抑制剂选择性比较
BMI-1产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S7372 |
PTC-209PTC-209是一种有效的选择性BMI-1抑制剂,在HEK293T细胞系中IC50为0.5 μM,并导致癌症起始细胞(CICs)的不可逆减少。 |
![]() ![]() Immunoblot analysis of BMI-1 and H2AK119Ub levels following 72 h treatment with 10 µM PTC-209. β-actin and total H2A served as loading controls.
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S8820 |
PTC596PTC596是第二代BMI-1抑制剂,可加速BMI-1的降解。PTC596 可下调 MCL-1 并诱导p53依赖性的线粒体的凋亡。处理套细胞淋巴瘤细胞72小时,IC50为68-340 nM。 |
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S5315 |
PRT4165PRT4165 is a Bmi1/Ring1A inhibitor with an IC50 of 3.9 µM in the cell-free assay and also inhibits PRC1-mediated H2A ubiquitylation in vivo and in vitro. |
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S7539 |
PTC-209 HBrPTC-209 HBr 是PTC-209的氢溴酸盐 , 这是一种强效的选择性的BMI-1抑制剂,其IC50为0.5 μM, 可以不可逆的减少癌起始细胞(CICs)。 |
![]() ![]() b Reduced viability 96 h post treatment was observed in all MM cell lines in a dose-dependent manner, but not in BMSCs or PBMCs (c). d Downregulation of CCND1 and MYC as well as upregulation of CDNK1A and CDKN1B was noted 5 h post treatment. e Deregulation of proliferation-associated genes translated into a significant increase of cells in the G1 phase and concurrent decrease in the S and G2M phase of the cell cycle 24 h post treatment. ***P < 0.001, **P < 0.01 and *P < 0.05 vs DMSO control
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S8662 |
PTC-028PTC-028是一种具有生物口服活性的化合物,能够通过翻译后修饰减少BMI-1水平。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S7372 |
PTC-209PTC-209是一种有效的选择性BMI-1抑制剂,在HEK293T细胞系中IC50为0.5 μM,并导致癌症起始细胞(CICs)的不可逆减少。 |
![]() ![]() Immunoblot analysis of BMI-1 and H2AK119Ub levels following 72 h treatment with 10 µM PTC-209. β-actin and total H2A served as loading controls.
|
|
S8820 |
PTC596PTC596是第二代BMI-1抑制剂,可加速BMI-1的降解。PTC596 可下调 MCL-1 并诱导p53依赖性的线粒体的凋亡。处理套细胞淋巴瘤细胞72小时,IC50为68-340 nM。 |
||
S5315 |
PRT4165PRT4165 is a Bmi1/Ring1A inhibitor with an IC50 of 3.9 µM in the cell-free assay and also inhibits PRC1-mediated H2A ubiquitylation in vivo and in vitro. |
||
S7539 |
PTC-209 HBrPTC-209 HBr 是PTC-209的氢溴酸盐 , 这是一种强效的选择性的BMI-1抑制剂,其IC50为0.5 μM, 可以不可逆的减少癌起始细胞(CICs)。 |
![]() ![]() b Reduced viability 96 h post treatment was observed in all MM cell lines in a dose-dependent manner, but not in BMSCs or PBMCs (c). d Downregulation of CCND1 and MYC as well as upregulation of CDNK1A and CDKN1B was noted 5 h post treatment. e Deregulation of proliferation-associated genes translated into a significant increase of cells in the G1 phase and concurrent decrease in the S and G2M phase of the cell cycle 24 h post treatment. ***P < 0.001, **P < 0.01 and *P < 0.05 vs DMSO control
|
|
S8662 |
PTC-028PTC-028是一种具有生物口服活性的化合物,能够通过翻译后修饰减少BMI-1水平。 |