BMI-1
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S7372 | PTC-209 | <1 mg/mL | 99 mg/mL | <1 mg/mL |
| S5315 | PRT4165 | <1 mg/mL | 11 mg/mL | 4 mg/mL |
| S7539 | PTC-209 HBr | <1 mg/mL | 100 mg/mL | <1 mg/mL |
| S8662 | PTC-028 | <1 mg/mL | 81 mg/mL | 17 mg/mL |
- BMI-1抑制剂（4）
- 新BMI-1产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7372 |
PTC-209PTC-209是一种有效的选择性BMI-1抑制剂，在HEK293T细胞系中IC50为0.5 μM，并导致癌症起始细胞(CICs)的不可逆减少。 |
Immunoblot analysis of BMI-1 and H2AK119Ub levels following 72 h treatment with 10 µM PTC-209. β-actin and total H2A served as loading controls.
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| S5315New |
PRT4165PRT4165 is a Bmi1/Ring1A inhibitor with an IC50 of 3.9 µM in the cell-free assay and also inhibits PRC1-mediated H2A ubiquitylation in vivo and in vitro. |
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| S7539 |
PTC-209 HBrPTC-209 HBr 是PTC-209的氢溴酸盐 , 这是一种强效的选择性的BMI-1抑制剂，其IC50为0.5 μM, 可以不可逆的减少癌起始细胞(CICs)。 |
b Reduced viability 96 h post treatment was observed in all MM cell lines in a dose-dependent manner, but not in BMSCs or PBMCs (c). d Downregulation of CCND1 and MYC as well as upregulation of CDNK1A and CDKN1B was noted 5 h post treatment. e Deregulation of proliferation-associated genes translated into a significant increase of cells in the G1 phase and concurrent decrease in the S and G2M phase of the cell cycle 24 h post treatment. ***P < 0.001, **P < 0.01 and *P < 0.05 vs DMSO control
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| S8662New |
PTC-028PTC-028是一种具有生物口服活性的化合物，能够通过翻译落修饰减少BMI-1水平。 |
