cAMP

信号通路图

研究领域

抑制剂选择性比较

特异性亚型抑制剂

AC Selective

cAMP产品

所有产品 cAMP抑制剂(6) cAMP激活剂(1) cAMP激动剂(1)

产品目录	产品描述	文献引用	实验数据
S8414	PACAP 1-27 垂体腺苷环化酶激活肽(PACAP 1-27)是有效的PACAP受体拮抗剂。
S7499	ESI-09 ESI-09是一种特定的exchange protein directly activated by cAMP (EPAC)抑制剂，其对EPAC1和EPAC2的IC50分别为3.2 μM 和1.4 μM ，比PKA高出100多倍的选择性。	Biomed Pharmacother, 2019, 109:1268-1275 Inflammation, 2018, 41(3):1093-1103 Acta Diabetol, 2017, 54(6):581-591	PKA but not Epac blockade reversed the JWH133-mediated effects on the microglial phenotypic conversion. PKA (H89) or Epac (ESI-09) specific inhibitors were treated with JWH133. qPCR was used to investigate mRNA expression of the M1 markers CD86 (A) and CD68 (B), as well as the M2 markers Ym1 (D) and CD206 (E). Western blot analysis was conducted, and the relative CD68 (C) and CD206 (F) densities were evaluated for further determinations. The data are expressed as means ± SD. P < 0.01, *P < 0.001 vs. Throm; #P < 0.05, ##P < 0.01 vs. Throm + JWH; n = 3 per group.
S8416	PACAP 6-38 PACAP 6-38 是PACAP (pituitary adenylate cyclase-activating polypeptide)的非刺激性竞争性拮抗剂，IC50为2 nM。在体内，它还能作为功能性的CARTp拮抗剂。
S7500	HJC0350 HJC0350 是强效的选择性的EPAC2抑制剂，IC50为0.3 μM,对Epac1无抑制作用。
S8283	SQ22536 SQ22536是腺苷酸环化酶的抑制剂。可在完整人类血小板中抑制PGE-1刺激的cAMP水平升高。	J Clin Endocrinol Metab, 2019, 104(5):1697-1711 Arterioscler Thromb Vasc Biol, 2018, 38(5):1115-1124 J Food Sci, 2018, 83(9):2394-2401	Effects of AC inhibitor SQ22536 on A20 cell proliferation and expression of cAMP, Reelin, CDK5, IL-10 and caspase-3. (A) The expression level of cAMP in A20 cells treated with SQ22536 using ELISA assay. (B) The proliferation rate analysis of A20 cell treated with SQ22536 using CCK-8 assay. (C) Western blotting determined the expression levels of Reelin, CDK5, caspase-3 and IL-10 in A20 treated with SQ22536. **p<0.01.
S4552	Bithionol Bithionol是有效的sAC（可溶性腺苷酸环化酶）抑制剂，IC50为4 μM。具有抗菌、驱肠虫以及除海藻活性。
S2449	Forskolin Forskolin在各种各样细胞类型中，是一种普遍存在的真核细胞腺苷酸环化酶（AC）激活剂，在细胞生理学研究中，通常用来提高cAMP水平。	EMBO J, 2019, 38(4) Mol Ther, 2019, 10.1016/j.ymthe.2019.08.011 Mol Ther Nucleic Acids, 2019, 16:73-81
S8415	PACAP 1-38 PACAP 1-38是高度有效的PACAP受体激动剂（Kd=100 pM），能够刺激腺苷酸环化酶和吞噬作用。

产品目录	产品描述	文献引用	实验数据
S8414	PACAP 1-27 垂体腺苷环化酶激活肽(PACAP 1-27)是有效的PACAP受体拮抗剂。
S7499	ESI-09 ESI-09是一种特定的exchange protein directly activated by cAMP (EPAC)抑制剂，其对EPAC1和EPAC2的IC50分别为3.2 μM 和1.4 μM ，比PKA高出100多倍的选择性。	Biomed Pharmacother,2019, 109:1268-1275 Inflammation,2018, 41(3):1093-1103 Acta Diabetol,2017, 54(6):581-591	PKA but not Epac blockade reversed the JWH133-mediated effects on the microglial phenotypic conversion. PKA (H89) or Epac (ESI-09) specific inhibitors were treated with JWH133. qPCR was used to investigate mRNA expression of the M1 markers CD86 (A) and CD68 (B), as well as the M2 markers Ym1 (D) and CD206 (E). Western blot analysis was conducted, and the relative CD68 (C) and CD206 (F) densities were evaluated for further determinations. The data are expressed as means ± SD. P < 0.01, *P < 0.001 vs. Throm; #P < 0.05, ##P < 0.01 vs. Throm + JWH; n = 3 per group.
S8416	PACAP 6-38 PACAP 6-38 是PACAP (pituitary adenylate cyclase-activating polypeptide)的非刺激性竞争性拮抗剂，IC50为2 nM。在体内，它还能作为功能性的CARTp拮抗剂。
S7500	HJC0350 HJC0350 是强效的选择性的EPAC2抑制剂，IC50为0.3 μM,对Epac1无抑制作用。
S8283	SQ22536 SQ22536是腺苷酸环化酶的抑制剂。可在完整人类血小板中抑制PGE-1刺激的cAMP水平升高。	J Clin Endocrinol Metab,2019, 104(5):1697-1711 Arterioscler Thromb Vasc Biol,2018, 38(5):1115-1124 J Food Sci,2018, 83(9):2394-2401	Effects of AC inhibitor SQ22536 on A20 cell proliferation and expression of cAMP, Reelin, CDK5, IL-10 and caspase-3. (A) The expression level of cAMP in A20 cells treated with SQ22536 using ELISA assay. (B) The proliferation rate analysis of A20 cell treated with SQ22536 using CCK-8 assay. (C) Western blotting determined the expression levels of Reelin, CDK5, caspase-3 and IL-10 in A20 treated with SQ22536. **p<0.01.
S4552	Bithionol Bithionol是有效的sAC（可溶性腺苷酸环化酶）抑制剂，IC50为4 μM。具有抗菌、驱肠虫以及除海藻活性。

产品目录

产品描述

文献引用

实验数据

S2449

Forskolin

Forskolin在各种各样细胞类型中，是一种普遍存在的真核细胞腺苷酸环化酶（AC）激活剂，在细胞生理学研究中，通常用来提高cAMP水平。

EMBO J, 2019, 38(4)

Mol Ther, 2019, 10.1016/j.ymthe.2019.08.011

Mol Ther Nucleic Acids, 2019, 16:73-81

产品目录

产品描述

文献引用

实验数据

S8415

PACAP 1-38

PACAP 1-38是高度有效的PACAP受体激动剂（Kd=100 pM），能够刺激腺苷酸环化酶和吞噬作用。