Dynamin

抑制剂选择性比较

特异性亚型抑制剂

Dynamin产品

所有产品(5) Dynamin抑制剂(5)

目录号	产品描述	文献引用	实验数据
S8047	Dynasore Dynasore 是一种细胞渗透性的，可逆的，非竞争性dynamin抑制剂，抑制dynamin 1/2的GTPase活性，无细胞试验中IC50为15 μM，也抑制线粒体dynamin Drp1，对其他小GTP酶没有作用效果。Dynasore 可抑制 mTORC1 活性并诱导自噬。Dynasore 抑制多种病毒的入侵，包括HSV。	Theranostics, 2021, 11(5):2364-2380 J Mater Chem B, 2021, 9(11):2641-2655 Front Microbiol, 2021, 12:636307	Immunocytochemistry demonstrates NR4A1 nuclear location at control (non-chymase treated) in HL-1 cells (a). Chymase (2.5 ug/ml) treatment for 2 h induces NR4A1 (red) cytoplasmic translocation in HL-1 cells as well as myosin (green) disruption (panel b). Active chymase enters HL-1 cells and is prevented by Dynasore (c and d). There marked entry into HL-1 cell nuclei and cytoplasm after treatment with chymase (5 ug/ml) for 2 h that is prevented by pre-treatment with Dynasore. Lack of co-staining with caveolin 3 (green) demonstrates that chymase is not transported via caveolae. Dynasore prevents transferrin uptake in HL-1 cells.
S7162	Mdivi-1 Mdivi-1 (Mitochondrial division inhibitor 1)是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂，抑制了DRP1（发动蛋白相关GTP酶）和Dynamin I (Dnm1)的IC50为1-10 μM。Mdivi-1 可减少线粒体自噬而增加细胞凋亡。	Free Radic Biol Med, 2021, S0891-5849(21)00198-2 J Cell Physiol, 2021, 10.1002/jcp.30386 Environ Pollut, 2021, 283:117082	a Representative TUNEL/DAPI photomicrographs of ipsilateral cortex in different groups (scale bar = 100 μm).
S9887^New	P110 P110 是一种 dynamin-related protein 1 (Drp1) 特异性抑制剂，可直接与 Drp1 结合。
S7163	Dyngo-4a Dyngo-4a是一种有效的dynamin抑制剂，作用于DynI (brain)，DynI (rec)，和DynII (rec)，IC50分别为0.38 μM，1.1 μM，和 2.3 μM 。	Cell Chem Biol, 2021, S2451-9456(21)00265-8 Signal Transduct Target Ther, 2020, 5(1):214 Arch Biochem Biophys, 2020, 680:108239	Immunofluorescence analysis of EGFR distribution in HCC827 and H1650 cells treated with dynasore, dyngo-4a, or control reagents. Images were captured using a fluorescent microscope (Olympus BX63, 40X objective). Scale bar = 10 μm.
S5422	Trimethyloctadecylammonium bromide Trimethyloctadecylammonium bromide (Octadecyltrimethylammonium bromide, OcTMAB, C18TAB) is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ.

目录号	产品描述	文献引用	实验数据
S8047	Dynasore Dynasore 是一种细胞渗透性的，可逆的，非竞争性dynamin抑制剂，抑制dynamin 1/2的GTPase活性，无细胞试验中IC50为15 μM，也抑制线粒体dynamin Drp1，对其他小GTP酶没有作用效果。Dynasore 可抑制 mTORC1 活性并诱导自噬。Dynasore 抑制多种病毒的入侵，包括HSV。	Theranostics,2021, 11(5):2364-2380 J Mater Chem B,2021, 9(11):2641-2655 Front Microbiol,2021, 12:636307	Immunocytochemistry demonstrates NR4A1 nuclear location at control (non-chymase treated) in HL-1 cells (a). Chymase (2.5 ug/ml) treatment for 2 h induces NR4A1 (red) cytoplasmic translocation in HL-1 cells as well as myosin (green) disruption (panel b). Active chymase enters HL-1 cells and is prevented by Dynasore (c and d). There marked entry into HL-1 cell nuclei and cytoplasm after treatment with chymase (5 ug/ml) for 2 h that is prevented by pre-treatment with Dynasore. Lack of co-staining with caveolin 3 (green) demonstrates that chymase is not transported via caveolae. Dynasore prevents transferrin uptake in HL-1 cells.
S7162	Mdivi-1 Mdivi-1 (Mitochondrial division inhibitor 1)是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂，抑制了DRP1（发动蛋白相关GTP酶）和Dynamin I (Dnm1)的IC50为1-10 μM。Mdivi-1 可减少线粒体自噬而增加细胞凋亡。	Free Radic Biol Med,2021, S0891-5849(21)00198-2 J Cell Physiol,2021, 10.1002/jcp.30386 Environ Pollut,2021, 283:117082	a Representative TUNEL/DAPI photomicrographs of ipsilateral cortex in different groups (scale bar = 100 μm).
S9887^New	P110 P110 是一种 dynamin-related protein 1 (Drp1) 特异性抑制剂，可直接与 Drp1 结合。
S7163	Dyngo-4a Dyngo-4a是一种有效的dynamin抑制剂，作用于DynI (brain)，DynI (rec)，和DynII (rec)，IC50分别为0.38 μM，1.1 μM，和 2.3 μM 。	Cell Chem Biol,2021, S2451-9456(21)00265-8 Signal Transduct Target Ther,2020, 5(1):214 Arch Biochem Biophys,2020, 680:108239	Immunofluorescence analysis of EGFR distribution in HCC827 and H1650 cells treated with dynasore, dyngo-4a, or control reagents. Images were captured using a fluorescent microscope (Olympus BX63, 40X objective). Scale bar = 10 μm.
S5422	Trimethyloctadecylammonium bromide Trimethyloctadecylammonium bromide (Octadecyltrimethylammonium bromide, OcTMAB, C18TAB) is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ.