Dynamin

抑制剂选择性比较

特异性亚型抑制剂

Dynamin产品

所有产品(6) Dynamin抑制剂(6)

目录号	产品描述	文献引用	实验数据
S8047	Dynasore Dynasore 是一种细胞渗透性的，可逆的，非竞争性dynamin抑制剂，抑制dynamin 1/2的GTPase活性，无细胞试验中IC50为15 μM，也抑制线粒体dynamin Drp1，对其他小GTP酶没有作用效果。Dynasore 可抑制 mTORC1 活性并诱导自噬。Dynasore 抑制多种病毒的入侵，包括HSV。	Nature, 2022, 603(7899):159-165 J Neuroinflammation, 2022, 19(1):53 Cell Death Discov, 2022, 8(1):197	Immunocytochemistry demonstrates NR4A1 nuclear location at control (non-chymase treated) in HL-1 cells (a). Chymase (2.5 ug/ml) treatment for 2 h induces NR4A1 (red) cytoplasmic translocation in HL-1 cells as well as myosin (green) disruption (panel b). Active chymase enters HL-1 cells and is prevented by Dynasore (c and d). There marked entry into HL-1 cell nuclei and cytoplasm after treatment with chymase (5 ug/ml) for 2 h that is prevented by pre-treatment with Dynasore. Lack of co-staining with caveolin 3 (green) demonstrates that chymase is not transported via caveolae. Dynasore prevents transferrin uptake in HL-1 cells.
S7162	Mdivi-1 Mdivi-1 (Mitochondrial division inhibitor 1)是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂，抑制了DRP1（发动蛋白相关GTP酶）和Dynamin I (Dnm1)的IC50为1-10 μM。Mdivi-1 可减少线粒体自噬而增加细胞凋亡。	Exp Mol Med, 2022, 10.1038/s12276-022-00745-9 Oxid Med Cell Longev, 2022, 2022:3745135 Cancer Discov, 2022, 12(1):250-269	a Representative TUNEL/DAPI photomicrographs of ipsilateral cortex in different groups (scale bar = 100 μm).
S9887^New	P110 P110 是一种 dynamin-related protein 1 (Drp1) 特异性抑制剂，可直接与 Drp1 结合。
E1081^New	MiTMAB MiTMAB 是一种选择性的动力蛋白（dynamin）抑制剂，靶向动力蛋白-磷脂的相互作用。 MiTMAB 抑制 dynamin GTPase 活性，Ki 为 940 nM。
S7163	Dyngo-4a Dyngo-4a是一种有效的dynamin抑制剂，作用于DynI (brain)，DynI (rec)，和DynII (rec)，IC50分别为0.38 μM，1.1 μM，和 2.3 μM 。	Nature, 2022, 603(7899):159-165 Theranostics, 2022, 12(3):1148-1160 Explor Target Antitumor Ther, 2022, 3:37-49	Immunofluorescence analysis of EGFR distribution in HCC827 and H1650 cells treated with dynasore, dyngo-4a, or control reagents. Images were captured using a fluorescent microscope (Olympus BX63, 40X objective). Scale bar = 10 μm.
S5422	Trimethyloctadecylammonium bromide Trimethyloctadecylammonium bromide (Octadecyltrimethylammonium bromide, OcTMAB, C18TAB) is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ.

目录号	产品描述	文献引用	实验数据
S8047	Dynasore Dynasore 是一种细胞渗透性的，可逆的，非竞争性dynamin抑制剂，抑制dynamin 1/2的GTPase活性，无细胞试验中IC50为15 μM，也抑制线粒体dynamin Drp1，对其他小GTP酶没有作用效果。Dynasore 可抑制 mTORC1 活性并诱导自噬。Dynasore 抑制多种病毒的入侵，包括HSV。	Nature,2022, 603(7899):159-165 J Neuroinflammation,2022, 19(1):53 Cell Death Discov,2022, 8(1):197	Immunocytochemistry demonstrates NR4A1 nuclear location at control (non-chymase treated) in HL-1 cells (a). Chymase (2.5 ug/ml) treatment for 2 h induces NR4A1 (red) cytoplasmic translocation in HL-1 cells as well as myosin (green) disruption (panel b). Active chymase enters HL-1 cells and is prevented by Dynasore (c and d). There marked entry into HL-1 cell nuclei and cytoplasm after treatment with chymase (5 ug/ml) for 2 h that is prevented by pre-treatment with Dynasore. Lack of co-staining with caveolin 3 (green) demonstrates that chymase is not transported via caveolae. Dynasore prevents transferrin uptake in HL-1 cells.
S7162	Mdivi-1 Mdivi-1 (Mitochondrial division inhibitor 1)是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂，抑制了DRP1（发动蛋白相关GTP酶）和Dynamin I (Dnm1)的IC50为1-10 μM。Mdivi-1 可减少线粒体自噬而增加细胞凋亡。	Exp Mol Med,2022, 10.1038/s12276-022-00745-9 Oxid Med Cell Longev,2022, 2022:3745135 Cancer Discov,2022, 12(1):250-269	a Representative TUNEL/DAPI photomicrographs of ipsilateral cortex in different groups (scale bar = 100 μm).
S9887^New	P110 P110 是一种 dynamin-related protein 1 (Drp1) 特异性抑制剂，可直接与 Drp1 结合。
E1081^New	MiTMAB MiTMAB 是一种选择性的动力蛋白（dynamin）抑制剂，靶向动力蛋白-磷脂的相互作用。 MiTMAB 抑制 dynamin GTPase 活性，Ki 为 940 nM。
S7163	Dyngo-4a Dyngo-4a是一种有效的dynamin抑制剂，作用于DynI (brain)，DynI (rec)，和DynII (rec)，IC50分别为0.38 μM，1.1 μM，和 2.3 μM 。	Nature,2022, 603(7899):159-165 Theranostics,2022, 12(3):1148-1160 Explor Target Antitumor Ther,2022, 3:37-49	Immunofluorescence analysis of EGFR distribution in HCC827 and H1650 cells treated with dynasore, dyngo-4a, or control reagents. Images were captured using a fluorescent microscope (Olympus BX63, 40X objective). Scale bar = 10 μm.
S5422	Trimethyloctadecylammonium bromide Trimethyloctadecylammonium bromide (Octadecyltrimethylammonium bromide, OcTMAB, C18TAB) is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ.