Dynamin
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S8047 | Dynasore | <1 mg/mL | 64 mg/mL | <1 mg/mL |
| S7162 | Mdivi-1 | <1 mg/mL | 70 mg/mL | <1 mg/mL |
| S7163 | Dyngo-4a | <1 mg/mL | 67 mg/mL | 1 mg/mL |
| S5422 | Trimethyloctadecylammonium bromide | -1 mg/mL | 11 mg/mL | -1 mg/mL |
- Dynamin抑制剂（4）
- 新Dynamin产品
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S8047 |
DynasoreDynasore是一种细胞渗透性的，可逆的，非竞争性dynamin抑制剂，抑制dynamin 1/2的GTPase活性，无细胞试验中IC50为15 μM，也抑制线粒体dynamin Drp1，对其他小GTP酶没有作用效果。 |
Effects of dynasore on active caspase-3 expression at 3 days after SCI. c) Active caspase-3/NeuN/DAPI double labeling. Scale bars = 100 μm. |
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| S7162 |
Mdivi-1Mdivi-1是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂，抑制了DRP1（发动蛋白相关GTP酶）和Dynamin I (Dnm1)的IC50为1-10 μM。 |
A. shCon and shPINK1 cells were pretreated with Mdivi-1 (50 μM) for 2 h, followed by treatment with 8 μM PPI for 6 h. Mitochondrial fractions (Mito) were prepared and subjected to western blot analysis. B-C. RFP-mito-expressing cells were treated as indicated in (A), and fluorescence images were evaluated by confocal microscopy. Scale bars: 10 μm. Average mitochondrial length was quantified as previously described. Data are presented as mean ± SD (*P< 0.01 compared to shCon cells treated with PPI, ##P< 0.01 compared to shPINK1 cells treated with PPI). D-E. Cells were treated as indicated in (A); apoptosis was then measured by flow cytometry, and whole-cell lysates were prepared and subjected to western blot analysis. Data are presented as mean ± SD (*P< 0.01 compared to shCon cells treated with PPI, ##P< 0.01 compared to shPINK1 cells treated with PPI).
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| S7163 |
Dyngo-4aDyngo-4a是一种有效的dynamin抑制剂，作用于DynI (brain)，DynI (rec)，和DynII (rec)，IC50分别为0.38 μM，1.1 μM，和 2.3 μM 。 |
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| S5422New |
Trimethyloctadecylammonium bromideTrimethyloctadecylammonium bromide is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ. |
