Dynamin

抑制剂选择性比较

Dynamin产品

所有产品 Dynamin抑制剂(4)

产品目录	产品描述	文献引用	实验数据
S8047	Dynasore Dynasore是一种细胞渗透性的，可逆的，非竞争性dynamin抑制剂，抑制dynamin 1/2的GTPase活性，无细胞试验中IC50为15 μM，也抑制线粒体dynamin Drp1，对其他小GTP酶没有作用效果。	Emerg Microbes Infect, 2019, 8(1):773-786 Biochem Biophys Res Commun, 2018, 495(1):1158-1166 Virol J, 2018, 15(1):1	Immunocytochemistry demonstrates NR4A1 nuclear location at control (non-chymase treated) in HL-1 cells (a). Chymase (2.5 ug/ml) treatment for 2 h induces NR4A1 (red) cytoplasmic translocation in HL-1 cells as well as myosin (green) disruption (panel b). Active chymase enters HL-1 cells and is prevented by Dynasore (c and d). There marked entry into HL-1 cell nuclei and cytoplasm after treatment with chymase (5 ug/ml) for 2 h that is prevented by pre-treatment with Dynasore. Lack of co-staining with caveolin 3 (green) demonstrates that chymase is not transported via caveolae. Dynasore prevents transferrin uptake in HL-1 cells.
S7162	Mdivi-1 Mdivi-1是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂，抑制了DRP1（发动蛋白相关GTP酶）和Dynamin I (Dnm1)的IC50为1-10 μM。	Cell Tissue Res, 2019, 10.1007/s00441-019-03126-3 Biomed Pharmacother, 2018, 103:1408-1414 J Cell Mol Med, 2018, 10.1111/jcmm.13975	a Representative TUNEL/DAPI photomicrographs of ipsilateral cortex in different groups (scale bar = 100 μm).
S7163	Dyngo-4a Dyngo-4a是一种有效的dynamin抑制剂，作用于DynI (brain)，DynI (rec)，和DynII (rec)，IC50分别为0.38 μM，1.1 μM，和 2.3 μM 。	Cell Commun Signal, 2018, 16(1):40 J Immunol, 2018, 200(3):997-1007 J Struct Biol, 2018, 10.1016/j.jsb.2018.10.007	Immunofluorescence analysis of EGFR distribution in HCC827 and H1650 cells treated with dynasore, dyngo-4a, or control reagents. Images were captured using a fluorescent microscope (Olympus BX63, 40X objective). Scale bar = 10 μm.
S5422	Trimethyloctadecylammonium bromide Trimethyloctadecylammonium bromide is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ.

产品目录	产品描述	文献引用	实验数据
S8047	Dynasore Dynasore是一种细胞渗透性的，可逆的，非竞争性dynamin抑制剂，抑制dynamin 1/2的GTPase活性，无细胞试验中IC50为15 μM，也抑制线粒体dynamin Drp1，对其他小GTP酶没有作用效果。	Emerg Microbes Infect,2019, 8(1):773-786 Biochem Biophys Res Commun,2018, 495(1):1158-1166 Virol J,2018, 15(1):1	Immunocytochemistry demonstrates NR4A1 nuclear location at control (non-chymase treated) in HL-1 cells (a). Chymase (2.5 ug/ml) treatment for 2 h induces NR4A1 (red) cytoplasmic translocation in HL-1 cells as well as myosin (green) disruption (panel b). Active chymase enters HL-1 cells and is prevented by Dynasore (c and d). There marked entry into HL-1 cell nuclei and cytoplasm after treatment with chymase (5 ug/ml) for 2 h that is prevented by pre-treatment with Dynasore. Lack of co-staining with caveolin 3 (green) demonstrates that chymase is not transported via caveolae. Dynasore prevents transferrin uptake in HL-1 cells.
S7162	Mdivi-1 Mdivi-1是一个具有选择性和细胞穿膜性的线粒体分裂抑制剂，抑制了DRP1（发动蛋白相关GTP酶）和Dynamin I (Dnm1)的IC50为1-10 μM。	Cell Tissue Res,2019, 10.1007/s00441-019-03126-3 Biomed Pharmacother,2018, 103:1408-1414 J Cell Mol Med,2018, 10.1111/jcmm.13975	a Representative TUNEL/DAPI photomicrographs of ipsilateral cortex in different groups (scale bar = 100 μm).
S7163	Dyngo-4a Dyngo-4a是一种有效的dynamin抑制剂，作用于DynI (brain)，DynI (rec)，和DynII (rec)，IC50分别为0.38 μM，1.1 μM，和 2.3 μM 。	Cell Commun Signal,2018, 16(1):40 J Immunol,2018, 200(3):997-1007 J Struct Biol,2018, 10.1016/j.jsb.2018.10.007	Immunofluorescence analysis of EGFR distribution in HCC827 and H1650 cells treated with dynasore, dyngo-4a, or control reagents. Images were captured using a fluorescent microscope (Olympus BX63, 40X objective). Scale bar = 10 μm.
S5422	Trimethyloctadecylammonium bromide Trimethyloctadecylammonium bromide is a Dynamin I inhibitor with an IC50 of 1.9 μM and also inhibits Dynamin Ⅱ.