E2 conjugating
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S2913 | BAY 11-7082 | <1 mg/mL | 41 mg/mL | 10 mg/mL |
| S7142 | NSC697923 | <1 mg/mL | 53 mg/mL | <1 mg/mL |
- E2 conjugating抑制剂（2）
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S2913 |
BAY 11-7082BAY 11-7082是一种NF-κB抑制剂，抑制TNFα诱导的IκBα磷酸化，在肿瘤细胞中IC50为10 μM。同时对泛素化系统的组分也有抑制作用。 |
Immunofluorescence images of Ishikawa cells showing the increase in the nuclear colocalization of ERa (red) and p65 (green) after E2 incubation. Nuclear colocalization is yellow. Treatment with ICI 182,780, PDTC or Bay inhibited the nuclear localization of both ERa and p65. Blue, DAPI-stained nuclei. All pictures were obtained the same day using the same microscope settings. Original magnification 3200, bar =50 um. Arrows, cytoplasmic ERa and p65 staining. ICI, ICI 182,780; Bay, Bay 11-7082.
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| S7142 |
NSC697923NSC697923 是一种细胞选择透过性Ub-conjugating enzyme (E2)复合Ubc13-Uev1A 抑制剂. |
Immunofluorescence analysis of b-actin distribution and Lys63 ubiquitination in HK2 cells. Cells were preincubated with the specific inhibitor of the Ubc13–Uev1A complex NSC697923, in the indicated conditions before D-glucose was added. The results represent 4 independent experiments.
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