MPS1

抑制剂选择性比较

MPS1产品

目录号 产品描述 文献引用 实验数据
S2731

AZ 3146

AZ 3146是一种选择性Mps1抑制剂,IC50为35 nM左右,有助于聚集CENP-E(驱动蛋白相关的动力蛋白),对FAK, JNK1, JNK2和Kit作用效果稍弱。

S8214New

Empesertib (BAY1161909)

Empesertib (BAY1161909), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib (BAY1161909) has potential antineoplastic activity.

S8215

BAY 1217389

BAY 1217389一种具有生物口服活性的、选择性丝氨酸/苏氨酸激酶monopolar spindle 1 (Mps1)抑制剂,IC50低于10 nM,具有良好的选择性。

S8911New

BOS172722

BOS-172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 2 nM.

S7488

MPI-0479605

MPI-0479605 是一种ATP竞争性的选择性的有丝分裂激酶Mps1抑制剂,IC50为1.8 nM, 其选择性超过其他激酶40倍。

S0426New

Pim1/AKK1-IN-1

Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd of 35 nM, 53 nM, 75 nM and 380 nM for Pim1, AKK1, MST2 and LKB1, respectively. Pim1/AKK1-IN-1 also inhibits MPSK1 and TNIK.

目录号 产品描述 文献引用 实验数据
S2731

AZ 3146

AZ 3146是一种选择性Mps1抑制剂,IC50为35 nM左右,有助于聚集CENP-E(驱动蛋白相关的动力蛋白),对FAK, JNK1, JNK2和Kit作用效果稍弱。

S8214New

Empesertib (BAY1161909)

Empesertib (BAY1161909), a derivative of triazolopyridine, is an orally bioavailable, selective inhibitor of the serine/threonine monopolar spindle 1 (Mps1) kinase with IC50 of <1 nM. Empesertib (BAY1161909) has potential antineoplastic activity.

S8215

BAY 1217389

BAY 1217389一种具有生物口服活性的、选择性丝氨酸/苏氨酸激酶monopolar spindle 1 (Mps1)抑制剂,IC50低于10 nM,具有良好的选择性。

S8911New

BOS172722

BOS-172722 is a monopolar spindle 1 (MPS1) checkpoint inhibitor with IC50 of 2 nM.

S7488

MPI-0479605

MPI-0479605 是一种ATP竞争性的选择性的有丝分裂激酶Mps1抑制剂,IC50为1.8 nM, 其选择性超过其他激酶40倍。

S0426New

Pim1/AKK1-IN-1

Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd of 35 nM, 53 nM, 75 nM and 380 nM for Pim1, AKK1, MST2 and LKB1, respectively. Pim1/AKK1-IN-1 also inhibits MPSK1 and TNIK.