PAI-1

抑制剂选择性比较

PAI-1产品

目录号 产品描述 文献引用 实验数据
S9194

Toddalolactone

Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM.

S7922

Tiplaxtinin (PAI-039)

Tiplaxtinin(PAI-039)是口服有效的选择性纤溶酶原激活物抑制剂-1(PAI-1)抑制剂,IC50为2.7 μM。

S3785

Notoginsenoside R1

Notoginsenoside R1 is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways.

S6776New

TM5275 Sodium

TM 5275 sodium 是一种口服的、生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制剂,其IC50值为6.95 μM。

S6778New

TM5441

TM5441是一种口服生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制剂,其IC50值介于9.7 μM 和60.3 μM 之间。TM5441可诱导几种人类癌细胞系的内源性细胞凋亡。

目录号 产品描述 文献引用 实验数据
S9194

Toddalolactone

Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM.

S7922

Tiplaxtinin (PAI-039)

Tiplaxtinin(PAI-039)是口服有效的选择性纤溶酶原激活物抑制剂-1(PAI-1)抑制剂,IC50为2.7 μM。

S3785

Notoginsenoside R1

Notoginsenoside R1 is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways.

S6776New

TM5275 Sodium

TM 5275 sodium 是一种口服的、生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制剂,其IC50值为6.95 μM。

S6778New

TM5441

TM5441是一种口服生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制剂,其IC50值介于9.7 μM 和60.3 μM 之间。TM5441可诱导几种人类癌细胞系的内源性细胞凋亡。