| S7922 |
Tiplaxtinin (PAI-039)
|
Tiplaxtinin(PAI-039)是口服有效的选择性纤溶酶原激活物抑制剂-1(PAI-1)抑制剂，IC50为2.7 μM。
|
-
Cell Death Dis, 2025, 16(1):529
-
Biomed Pharmacother, 2025, 189:118324
-
Int J Mol Sci, 2025, 26(1)401
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|
| S3785 |
Notoginsenoside R1
|
Notoginsenoside R1 (Sanchinoside R1) is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways. |
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Scientific Reports, 2026, 16(1):27251
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Food Sci Nutr, 2023, 11(12):7791-7802
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Food Science & Nutrition, 2023, 7791-7802
|
|
| S9194 |
Toddalolactone
|
Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM. |
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| S3242 |
Loureirin B
|
Loureirin B (LB, LrB)，是从Dracaena cochinchinensis中提取的类黄酮，是 PAI-1 的抑制剂，其IC50值为26.10 μM。Loureirin B 可下调TGF-β1刺激的成纤维细胞中的 p-ERK 和 p-JNK。Loureirin B 主要通过增加Pdx-1、MafA、细胞内ATP水平来促进胰岛素分泌，抑制 KATP 电流，Ca2+ 进入细胞内。 |
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| S6776 |
TM5275 Sodium
|
TM 5275 sodium 是一种口服的、生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制剂，其IC50值为6.95 μM。 |
|
|
| S6778 |
TM5441
|
TM5441是一种口服生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制剂，其IC50值介于9.7 μM 和60.3 μM 之间。TM5441可诱导几种人类癌细胞系的内源性细胞凋亡。 |
|
|
| S7922 |
Tiplaxtinin (PAI-039)
|
Tiplaxtinin(PAI-039)是口服有效的选择性纤溶酶原激活物抑制剂-1(PAI-1)抑制剂，IC50为2.7 μM。
|
- Cell Death Dis, 2025, 16(1):529
- Biomed Pharmacother, 2025, 189:118324
- Int J Mol Sci, 2025, 26(1)401
|
|
| S3785 |
Notoginsenoside R1
|
Notoginsenoside R1 (Sanchinoside R1) is the main ingredient with cardiovascular activity in Panax notoginseng. It inhibits TNF-α-induced PAI-1 overexpression via extracellular signal-related kinases (ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling pathways. |
- Scientific Reports, 2026, 16(1):27251
- Food Sci Nutr, 2023, 11(12):7791-7802
- Food Science & Nutrition, 2023, 7791-7802
|
|
| S9194 |
Toddalolactone
|
Toddalolactone, a natural coumarin, inhibits the activity of recombinant human Plasminogen activator inhibitor-1 (PAI-1) in a dose-dependent manner, yielding an IC50 value of 37.31 ± 3.23 μM. |
|
|
| S3242 |
Loureirin B
|
Loureirin B (LB, LrB)，是从Dracaena cochinchinensis中提取的类黄酮，是 PAI-1 的抑制剂，其IC50值为26.10 μM。Loureirin B 可下调TGF-β1刺激的成纤维细胞中的 p-ERK 和 p-JNK。Loureirin B 主要通过增加Pdx-1、MafA、细胞内ATP水平来促进胰岛素分泌，抑制 KATP 电流，Ca2+ 进入细胞内。 |
|
|
| S6776 |
TM5275 Sodium
|
TM 5275 sodium 是一种口服的、生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制剂，其IC50值为6.95 μM。 |
|
|
| S6778 |
TM5441
|
TM5441是一种口服生物活性的 plasminogen activator inhibitor-1 (PAI-1) 抑制剂，其IC50值介于9.7 μM 和60.3 μM 之间。TM5441可诱导几种人类癌细胞系的内源性细胞凋亡。 |
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