Parasite

抑制剂选择性比较

Parasite产品

目录号 产品描述 文献引用 实验数据
S2468

Fenbendazole

Fenbendazole 是一种广谱苯并咪唑类驱虫药,作用于胃肠道寄生虫,IC50为0.01 μg/ml。

S1837

Flubendazole

Flubendazole (Flumoxanal, NSC 313680)是一种驱虫剂,作用于MDAY-D2 细胞,IC50为3 nM。

S7379

E-64

E-64是一种非可逆的、选择性的半胱氨酸蛋白酶抑制剂,同样也抑制木瓜蛋白酶、钙蛋白酶和cathepsins B、H,但不抑制丝氨酸蛋白酶或天冬氨酸蛋白酶。抑制木瓜蛋白酶的IC50为9nM。E-64 可在丝虫的寄生虫中诱导氧化应激和凋亡。

S4044

Toltrazuril

Toltrazuril 是一种抗原生动物药剂,对球虫寄生虫有活性。

S3741

Benznidazole

Benznidazole (Radanil)是一种硝基咪唑衍生物,能够干扰寄生虫蛋白质的生物合成、影响其细胞因子的产生、刺激宿主的吞噬作用,因而具有抗原虫活性。

S0081New

DDD107498 succinate

DDD107498 succinate (M-5717, DDD-498 succinate) is a potent and orally active antimalarial agent. DDD107498 succinate inhibits multiple life-cycle stages of the parasite with EC50 of 1 nM against P. falciparum 3D7. DDD107498 succinate inhibits protein synthesis by targeting eEF2/CaMKIII with EC50 of 2 nM for WT-PfeEF2.

S4422

Nitenpyram

Nitenpyram是一个nicotinic acetylcholine receptor (AchR)激动剂,用于兽医对家畜和宠物寄生虫的治疗。

S3889

Arteether

Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.

S5557

Aklomide

Aklomide (2-Chloro-4-nitrobenzamide) is a coccidiostat and used to fight disease, parasites and insects that infest poultry.

S4564

Diethylcarbamazine citrate

Diethylcarbamazine citrate是丝虫微丝蚴中花生四烯酸代谢的抑制剂,对几种寄生虫高度特异,不含任何有毒金属元素。

S5247

Selamectin

Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.

目录号 产品描述 文献引用 实验数据
S2468

Fenbendazole

Fenbendazole 是一种广谱苯并咪唑类驱虫药,作用于胃肠道寄生虫,IC50为0.01 μg/ml。

S1837

Flubendazole

Flubendazole (Flumoxanal, NSC 313680)是一种驱虫剂,作用于MDAY-D2 细胞,IC50为3 nM。

S7379

E-64

E-64是一种非可逆的、选择性的半胱氨酸蛋白酶抑制剂,同样也抑制木瓜蛋白酶、钙蛋白酶和cathepsins B、H,但不抑制丝氨酸蛋白酶或天冬氨酸蛋白酶。抑制木瓜蛋白酶的IC50为9nM。E-64 可在丝虫的寄生虫中诱导氧化应激和凋亡。

S4044

Toltrazuril

Toltrazuril 是一种抗原生动物药剂,对球虫寄生虫有活性。

S3741

Benznidazole

Benznidazole (Radanil)是一种硝基咪唑衍生物,能够干扰寄生虫蛋白质的生物合成、影响其细胞因子的产生、刺激宿主的吞噬作用,因而具有抗原虫活性。

S0081New

DDD107498 succinate

DDD107498 succinate (M-5717, DDD-498 succinate) is a potent and orally active antimalarial agent. DDD107498 succinate inhibits multiple life-cycle stages of the parasite with EC50 of 1 nM against P. falciparum 3D7. DDD107498 succinate inhibits protein synthesis by targeting eEF2/CaMKIII with EC50 of 2 nM for WT-PfeEF2.

S4422

Nitenpyram

Nitenpyram是一个nicotinic acetylcholine receptor (AchR)激动剂,用于兽医对家畜和宠物寄生虫的治疗。

S3889

Arteether

Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.

S5557

Aklomide

Aklomide (2-Chloro-4-nitrobenzamide) is a coccidiostat and used to fight disease, parasites and insects that infest poultry.

S4564

Diethylcarbamazine citrate

Diethylcarbamazine citrate是丝虫微丝蚴中花生四烯酸代谢的抑制剂,对几种寄生虫高度特异,不含任何有毒金属元素。

S5247

Selamectin

Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.