Parasite

抑制剂选择性比较

Parasite产品

所有产品(11) Parasite抑制剂(11)

目录号	产品描述	文献引用	实验数据
S2468	Fenbendazole Fenbendazole 是一种广谱苯并咪唑类驱虫药，作用于胃肠道寄生虫，IC50为0.01 μg/ml。
S1837	Flubendazole Flubendazole (Flumoxanal, NSC 313680)是一种驱虫剂，作用于MDAY-D2 细胞，IC50为3 nM。	Sci Rep, 2020, 10(1):13124 RSC Advances, 2018, 10.1039/C7RA12259D	Inhibitory curves and IC50 values for the reference compound flubendazole (B) against VEGFR2.
S7379	E-64 E-64是一种非可逆的、选择性的半胱氨酸蛋白酶抑制剂，同样也抑制木瓜蛋白酶、钙蛋白酶和cathepsins B、H，但不抑制丝氨酸蛋白酶或天冬氨酸蛋白酶。抑制木瓜蛋白酶的IC50为9nM。E-64 可在丝虫的寄生虫中诱导氧化应激和凋亡。	J Am Soc Nephrol, 2020, 31(2):374-391 FASEB J, 2020, 34(9):12379-12391 bioRxiv, 2020, 2020.11.04.364315
S4044	Toltrazuril Toltrazuril 是一种抗原生动物药剂，对球虫寄生虫有活性。
S3741	Benznidazole Benznidazole (Radanil)是一种硝基咪唑衍生物，能够干扰寄生虫蛋白质的生物合成、影响其细胞因子的产生、刺激宿主的吞噬作用，因而具有抗原虫活性。
S0081^New	DDD107498 succinate DDD107498 succinate (M-5717, DDD-498 succinate) is a potent and orally active antimalarial agent. DDD107498 succinate inhibits multiple life-cycle stages of the parasite with EC50 of 1 nM against P. falciparum 3D7. DDD107498 succinate inhibits protein synthesis by targeting eEF2/CaMKIII with EC50 of 2 nM for WT-PfeEF2.
S4422	Nitenpyram Nitenpyram是一个nicotinic acetylcholine receptor (AchR)激动剂，用于兽医对家畜和宠物寄生虫的治疗。	Proc Natl Acad Sci U S A, 2020, 117(21):11321-11327
S3889	Arteether Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.	ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522
S5557	Aklomide Aklomide (2-Chloro-4-nitrobenzamide) is a coccidiostat and used to fight disease, parasites and insects that infest poultry.
S4564	Diethylcarbamazine citrate Diethylcarbamazine citrate是丝虫微丝蚴中花生四烯酸代谢的抑制剂，对几种寄生虫高度特异，不含任何有毒金属元素。
S5247	Selamectin Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.

目录号	产品描述	文献引用	实验数据
S2468	Fenbendazole Fenbendazole 是一种广谱苯并咪唑类驱虫药，作用于胃肠道寄生虫，IC50为0.01 μg/ml。
S1837	Flubendazole Flubendazole (Flumoxanal, NSC 313680)是一种驱虫剂，作用于MDAY-D2 细胞，IC50为3 nM。	Sci Rep,2020, 10(1):13124 RSC Advances,2018, 10.1039/C7RA12259D	Inhibitory curves and IC50 values for the reference compound flubendazole (B) against VEGFR2.
S7379	E-64 E-64是一种非可逆的、选择性的半胱氨酸蛋白酶抑制剂，同样也抑制木瓜蛋白酶、钙蛋白酶和cathepsins B、H，但不抑制丝氨酸蛋白酶或天冬氨酸蛋白酶。抑制木瓜蛋白酶的IC50为9nM。E-64 可在丝虫的寄生虫中诱导氧化应激和凋亡。	J Am Soc Nephrol,2020, 31(2):374-391 FASEB J,2020, 34(9):12379-12391 bioRxiv,2020, 2020.11.04.364315
S4044	Toltrazuril Toltrazuril 是一种抗原生动物药剂，对球虫寄生虫有活性。
S3741	Benznidazole Benznidazole (Radanil)是一种硝基咪唑衍生物，能够干扰寄生虫蛋白质的生物合成、影响其细胞因子的产生、刺激宿主的吞噬作用，因而具有抗原虫活性。
S0081^New	DDD107498 succinate DDD107498 succinate (M-5717, DDD-498 succinate) is a potent and orally active antimalarial agent. DDD107498 succinate inhibits multiple life-cycle stages of the parasite with EC50 of 1 nM against P. falciparum 3D7. DDD107498 succinate inhibits protein synthesis by targeting eEF2/CaMKIII with EC50 of 2 nM for WT-PfeEF2.
S4422	Nitenpyram Nitenpyram是一个nicotinic acetylcholine receptor (AchR)激动剂，用于兽医对家畜和宠物寄生虫的治疗。	Proc Natl Acad Sci U S A,2020, 117(21):11321-11327
S3889	Arteether Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.	ACS Infect Dis,2020, 10.1021/acsinfecdis.0c00522
S5557	Aklomide Aklomide (2-Chloro-4-nitrobenzamide) is a coccidiostat and used to fight disease, parasites and insects that infest poultry.
S4564	Diethylcarbamazine citrate Diethylcarbamazine citrate是丝虫微丝蚴中花生四烯酸代谢的抑制剂，对几种寄生虫高度特异，不含任何有毒金属元素。
S5247	Selamectin Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.