Parasite

抑制剂选择性比较

Parasite产品

所有产品(46) Parasite抑制剂(46)

目录号	产品描述	文献引用	实验数据
S2468	Fenbendazole Fenbendazole 是一种广谱苯并咪唑类驱虫药，作用于胃肠道寄生虫，IC50为0.01 μg/ml。
S1837	Flubendazole Flubendazole (Flumoxanal, NSC 313680)是一种驱虫剂，作用于MDAY-D2 细胞，IC50为3 nM。	Sci Rep, 2020, 10(1):13124 RSC Advances, 2018, 10.1039/C7RA12259D	Inhibitory curves and IC50 values for the reference compound flubendazole (B) against VEGFR2.
S7379	E-64 E-64是一种非可逆的、选择性的半胱氨酸蛋白酶抑制剂，同样也抑制木瓜蛋白酶、钙蛋白酶和cathepsins B、H，但不抑制丝氨酸蛋白酶或天冬氨酸蛋白酶。抑制木瓜蛋白酶的IC50为9nM。E-64 可在丝虫的寄生虫中诱导氧化应激和凋亡。	Molecules, 2022, 27(6)1755 Sci Adv, 2021, 7(3)eabc6364 Cell Chem Biol, 2021, S2451-9456(21)00213-0
S3079	Atovaquone Atovaquone (Atavaquone)用于治疗或预防肺孢子菌肺炎，弓形虫病, 疟疾和巴贝西虫。	J Cell Biochem, 2022, 10.1002/jcb.30213 Sci Rep, 2019, 9(1):536 Sci Transl Med, 2015, 7(290):290ra89
S2028	Diclazuril Diclazuril 是一种抗球虫药。	Hum Mol Genet, 2020, ddaa244
S1851	Oxibendazole Oxibendazole是一种广谱驱虫药。	Oncol Lett, 2018, 15(2):2218-2226
S2501	Pyrantel Pamoate Pyrantel pamoate (Pyrantel Embonate)是一种广谱驱虫剂，用于治疗一些寄生虫感染。
S1691	Praziquantel Praziquantel是一种驱虫药，有效作用于扁形虫。	Parasitology, 2020, 1-11 PLoS Negl Trop Dis, 2015, 9(3):e0003593	Schistosomicidal effects of PZQ, ART and OXA on 14-day-schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development.
S4141	Dinitolmide Dinitolmide (Zoalene) 是一种广谱抗球虫的药物。
S4044	Toltrazuril Toltrazuril 是一种抗原生动物药剂，对球虫寄生虫有活性。
S4094	Tetramisole HCl Tetramisole是右旋和左旋异构体的混合物，用作驱虫剂。
S1830	Oxfendazole Oxfendazole (RS-8858)是Fenbendazole的亚砜形式，是一种广谱的苯并咪唑类驱虫药。	Mol Med Rep, 2019, 19(4):2921-2926
S3999	α-santonin α-santonin, a naturally occurring sesquiterpene lactone, is a potent antiparasitic agent.
S3741	Benznidazole Benznidazole (Radanil)是一种硝基咪唑衍生物，能够干扰寄生虫蛋白质的生物合成、影响其细胞因子的产生、刺激宿主的吞噬作用，因而具有抗原虫活性。
S4866	Nicarbazin Nicarbazin是一种有效的抗球虫试剂，是一种广谱的寄生虫药物。
S4876	Robenidine Hydrochloride Robenidine Hydrochloride (Dexium, Nugatex, Rasexinium, Toraxine) 是一种应用于家禽中的抗球虫剂。
S4145	Decoquinate Decoquinate是一种球虫抑制药。
S4599	Benzyl benzoate Benzyl benzoate (Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester) 是治疗疥疮的旧制剂之一。
S4422	Nitenpyram Nitenpyram是一个nicotinic acetylcholine receptor (AchR)激动剂，用于兽医对家畜和宠物寄生虫的治疗。	Proc Natl Acad Sci U S A, 2020, 117(21):11321-11327
S0081	DDD107498 DDD107498 (M-5717, DDD-498) 是一种 P. falciparum translation elongation factor 2 的抑制剂。DDD107498 具有针对疟原虫寄生虫的多个生命周期阶段的有效地抗疟疾的活性。
S4610	Mebendazole Mebendazole (Vermox, Telmin, Pantelmin, Mebenvet) 是一种合成的苯并咪唑衍生物，还是一种驱虫药物。它能通过抑制寄生虫的胞质微管的形成，干扰它们的生殖和生存，有选择性的、不可逆的抑制糖吸收。	Genome Med, 2021, 13(1):146 Aging (Albany NY), 2021, 13(13):17407-17427 Am J Cancer Res, 2020, 10(8):2649-2676
S4167	Cyromazine Cyromazine是一种三嗪类昆虫生长调节剂，作为杀虫剂和杀螨剂。
S5722	Oxantel Pamoate Oxantel Pamoate is the pamoate salt form of oxantel, a tetrahydropyrimidine anthelmintic used against intesitnal worms, particularly in a veterinary setting.
S5345	Nerolidol Nerolidol (Peruviol) is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties.	Int Immunopharmacol, 2020, 80:106118
S4898	Sulfalozine sodium Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) 是一种抗原生动物药，用于球虫病的研究。
S4068	Tinidazole Tinidazole (CP12574)是抗寄生药。
S5816	Pyrvinium Pyrvinium是一种驱虫剂，对蛲虫有效。	Mol Carcinog, 2021, 10.1002/mc.23308 Med Oncol, 2021, 38(2):21 Front Microbiol, 2020, 11:579362
S4882	Resorantel Resorantel是一种安全的抗绦虫药，对莫尼茨绦虫和Thysaniezia spp.十分有效，对Paramphistomum spp.有一定效力。
S5017	Oxyclozanide Oxyclozanide (Oxiclozanidum, Zanil, Oxyclozanid, Zanilox)是N-水杨酰苯胺驱虫剂，也是线粒体解偶联驱虫剂。兽用。
S5948	Amodiaquine Amodiaquine是一种合成的氨基喹啉，通过与原生动物或寄生DNA结合、阻止DNA和RNA的生成以及后续蛋白质的合成。它被用于治疗疟疾。	Nat Biomed Eng, 2021, 10.1038/s41551-021-00718-9 bioRxiv, 2020, 10.1101/2020.04.13.039917 bioRxiv, 2020, 2020/9/20.4.7.30734
S3713	Moxidectin Moxidectin (Milbemycin B) is a potent, broad-spectrum endectocide with activity against a wide range of nematodes, insects and acari.
S3707	Ethopabate Ethopabate (ETP, Ethyl pabate)是一种球虫抑制剂，常被用于治疗鸡类球虫病。
S4104	Diminazene Aceturate Diminazene是一种二脒，也称4,4-（1-三氮烯-1,3-二取代基）双（苯甲脒)，用作有效的杀锥虫剂。	Am J Physiol Lung Cell Mol Physiol, 2020, 10.1152/ajplung.00025.2020
S5055	Milbemycin Oxime Milbemycin Oxime是广谱性抗寄生虫药物，对蠕虫和螨虫具有活性作用。
S5031	Sulfaquinoxaline sodium Sulfaquinoxaline sodium (N'1-quinoxalin-2-ylsulphanilamide sodium, SQ-Na)是sulfaquinoxaline的钠盐形式，通过抑制微生物的核酸、蛋白的合成，用于治疗家禽、猪、羊的球虫病。
S3889	Arteether Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.	ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522
S3591	Eprinomectin Eprinomectin (EPM, MK-397) 是一种极好的具有抗蠕虫、杀虫和杀螨活性的广谱杀菌剂。
S5094	Maduramycin Ammonium Maduramicin，可分离来源于放射菌类Actinomadura rubra，是一种抗原虫剂，用于阻止球虫病，兽用。	Cancers (Basel), 2019, 11(6)
S5093	Rafoxanide Rafoxanide (Disalan, Ranide, Flukanide, Bovanide)是一类N-水杨酰苯胺，被用作驱虫剂，在治疗和控制动物体内吸虫感染中有效。
S5092	Febantel Febantel (Rintal, Combotel, Oratel, Bay Vh 5757, Negabot Plus) 是一种前体药物，可代谢成为fenbendazole和oxfendazole，它们是活性驱虫剂。
S5557	Aklomide Aklomide (2-Chloro-4-nitrobenzamide) is a coccidiostat and used to fight disease, parasites and insects that infest poultry.
S0467	Emodepside Emodepside (QHT06, BAY 44-4400, PF 1022-221) 是一种PF1022A的半合成衍生物，是一种具有广谱的驱虫活性的环八肽。 Emodepside 可激活 Ca-dependent SLO-1-like K channels。
S4389	Bephenium Hydroxynaphthoate Bephenium 是一种 B-type Acetylcholine receptor (AChR) 的激活剂。Bephenium 可选择性地激活由Hco-UNC-29.1，Hco-UNC-38，Hco-UNC-63，Hco-ACR-8亚基组成的Hco-L-AChR1亚型。Bephenium hydroxynaphthoate 是一种驱虫药，以前用于治疗钩虫感染和蛔虫病。
S4564	Diethylcarbamazine citrate Diethylcarbamazine citrate是丝虫微丝蚴中花生四烯酸代谢的抑制剂，对几种寄生虫高度特异，不含任何有毒金属元素。
S4999	Avermectin B1 Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.
S5247	Selamectin Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.

目录号	产品描述	文献引用	实验数据
S2468	Fenbendazole Fenbendazole 是一种广谱苯并咪唑类驱虫药，作用于胃肠道寄生虫，IC50为0.01 μg/ml。
S1837	Flubendazole Flubendazole (Flumoxanal, NSC 313680)是一种驱虫剂，作用于MDAY-D2 细胞，IC50为3 nM。	Sci Rep,2020, 10(1):13124 RSC Advances,2018, 10.1039/C7RA12259D	Inhibitory curves and IC50 values for the reference compound flubendazole (B) against VEGFR2.
S7379	E-64 E-64是一种非可逆的、选择性的半胱氨酸蛋白酶抑制剂，同样也抑制木瓜蛋白酶、钙蛋白酶和cathepsins B、H，但不抑制丝氨酸蛋白酶或天冬氨酸蛋白酶。抑制木瓜蛋白酶的IC50为9nM。E-64 可在丝虫的寄生虫中诱导氧化应激和凋亡。	Molecules,2022, 27(6)1755 Sci Adv,2021, 7(3)eabc6364 Cell Chem Biol,2021, S2451-9456(21)00213-0
S3079	Atovaquone Atovaquone (Atavaquone)用于治疗或预防肺孢子菌肺炎，弓形虫病, 疟疾和巴贝西虫。	J Cell Biochem,2022, 10.1002/jcb.30213 Sci Rep,2019, 9(1):536 Sci Transl Med,2015, 7(290):290ra89
S2028	Diclazuril Diclazuril 是一种抗球虫药。	Hum Mol Genet,2020, ddaa244
S1851	Oxibendazole Oxibendazole是一种广谱驱虫药。	Oncol Lett,2018, 15(2):2218-2226
S2501	Pyrantel Pamoate Pyrantel pamoate (Pyrantel Embonate)是一种广谱驱虫剂，用于治疗一些寄生虫感染。
S1691	Praziquantel Praziquantel是一种驱虫药，有效作用于扁形虫。	Parasitology,2020, 1-11 PLoS Negl Trop Dis,2015, 9(3):e0003593	Schistosomicidal effects of PZQ, ART and OXA on 14-day-schistosomula. Magnification of the in vitro-cultured schistosomula treated with PZQ, ART, and OXA at 10 μM. Drugs were added at day 14 and schistosomula were analyzed at day 21 (late treatment). 0.1% DMSO in medium (solvent of the drugs; used as negative control) had no effect on schistosomula development.
S4141	Dinitolmide Dinitolmide (Zoalene) 是一种广谱抗球虫的药物。
S4044	Toltrazuril Toltrazuril 是一种抗原生动物药剂，对球虫寄生虫有活性。
S4094	Tetramisole HCl Tetramisole是右旋和左旋异构体的混合物，用作驱虫剂。
S1830	Oxfendazole Oxfendazole (RS-8858)是Fenbendazole的亚砜形式，是一种广谱的苯并咪唑类驱虫药。	Mol Med Rep,2019, 19(4):2921-2926
S3999	α-santonin α-santonin, a naturally occurring sesquiterpene lactone, is a potent antiparasitic agent.
S3741	Benznidazole Benznidazole (Radanil)是一种硝基咪唑衍生物，能够干扰寄生虫蛋白质的生物合成、影响其细胞因子的产生、刺激宿主的吞噬作用，因而具有抗原虫活性。
S4866	Nicarbazin Nicarbazin是一种有效的抗球虫试剂，是一种广谱的寄生虫药物。
S4876	Robenidine Hydrochloride Robenidine Hydrochloride (Dexium, Nugatex, Rasexinium, Toraxine) 是一种应用于家禽中的抗球虫剂。
S4145	Decoquinate Decoquinate是一种球虫抑制药。
S4599	Benzyl benzoate Benzyl benzoate (Ascabiol, Novoscabin, Scabitox, Benzoic acid benzyl ester) 是治疗疥疮的旧制剂之一。
S4422	Nitenpyram Nitenpyram是一个nicotinic acetylcholine receptor (AchR)激动剂，用于兽医对家畜和宠物寄生虫的治疗。	Proc Natl Acad Sci U S A,2020, 117(21):11321-11327
S0081	DDD107498 DDD107498 (M-5717, DDD-498) 是一种 P. falciparum translation elongation factor 2 的抑制剂。DDD107498 具有针对疟原虫寄生虫的多个生命周期阶段的有效地抗疟疾的活性。
S4610	Mebendazole Mebendazole (Vermox, Telmin, Pantelmin, Mebenvet) 是一种合成的苯并咪唑衍生物，还是一种驱虫药物。它能通过抑制寄生虫的胞质微管的形成，干扰它们的生殖和生存，有选择性的、不可逆的抑制糖吸收。	Genome Med,2021, 13(1):146 Aging (Albany NY),2021, 13(13):17407-17427 Am J Cancer Res,2020, 10(8):2649-2676
S4167	Cyromazine Cyromazine是一种三嗪类昆虫生长调节剂，作为杀虫剂和杀螨剂。
S5722	Oxantel Pamoate Oxantel Pamoate is the pamoate salt form of oxantel, a tetrahydropyrimidine anthelmintic used against intesitnal worms, particularly in a veterinary setting.
S5345	Nerolidol Nerolidol (Peruviol) is a naturally occurring sesquiterpene found in the essential oils of many types of plants and flowers. It has diverse range of pharmacological and biological activities including antioxidant, anti-microbial, anti-biofilm, anti-parasitic, insecticidal, anti-ulcer, skin penetration enhancer, anti-tumor, anti-nociceptive and anti-inflammatory properties.	Int Immunopharmacol,2020, 80:106118
S4898	Sulfalozine sodium Sulfalozine sodium (Sulfaclozine sodium, Sulfachlopryrazine sodium) 是一种抗原生动物药，用于球虫病的研究。
S4068	Tinidazole Tinidazole (CP12574)是抗寄生药。
S5816	Pyrvinium Pyrvinium是一种驱虫剂，对蛲虫有效。	Mol Carcinog,2021, 10.1002/mc.23308 Med Oncol,2021, 38(2):21 Front Microbiol,2020, 11:579362
S4882	Resorantel Resorantel是一种安全的抗绦虫药，对莫尼茨绦虫和Thysaniezia spp.十分有效，对Paramphistomum spp.有一定效力。
S5017	Oxyclozanide Oxyclozanide (Oxiclozanidum, Zanil, Oxyclozanid, Zanilox)是N-水杨酰苯胺驱虫剂，也是线粒体解偶联驱虫剂。兽用。
S5948	Amodiaquine Amodiaquine是一种合成的氨基喹啉，通过与原生动物或寄生DNA结合、阻止DNA和RNA的生成以及后续蛋白质的合成。它被用于治疗疟疾。	Nat Biomed Eng,2021, 10.1038/s41551-021-00718-9 bioRxiv,2020, 10.1101/2020.04.13.039917 bioRxiv,2020, 2020/9/20.4.7.30734
S3713	Moxidectin Moxidectin (Milbemycin B) is a potent, broad-spectrum endectocide with activity against a wide range of nematodes, insects and acari.
S3707	Ethopabate Ethopabate (ETP, Ethyl pabate)是一种球虫抑制剂，常被用于治疗鸡类球虫病。
S4104	Diminazene Aceturate Diminazene是一种二脒，也称4,4-（1-三氮烯-1,3-二取代基）双（苯甲脒)，用作有效的杀锥虫剂。	Am J Physiol Lung Cell Mol Physiol,2020, 10.1152/ajplung.00025.2020
S5055	Milbemycin Oxime Milbemycin Oxime是广谱性抗寄生虫药物，对蠕虫和螨虫具有活性作用。
S5031	Sulfaquinoxaline sodium Sulfaquinoxaline sodium (N'1-quinoxalin-2-ylsulphanilamide sodium, SQ-Na)是sulfaquinoxaline的钠盐形式，通过抑制微生物的核酸、蛋白的合成，用于治疗家禽、猪、羊的球虫病。
S3889	Arteether Arteether is a well-known antimalarial drug which acts by producing free radicals within the malarial parasite.	ACS Infect Dis,2020, 10.1021/acsinfecdis.0c00522
S3591	Eprinomectin Eprinomectin (EPM, MK-397) 是一种极好的具有抗蠕虫、杀虫和杀螨活性的广谱杀菌剂。
S5094	Maduramycin Ammonium Maduramicin，可分离来源于放射菌类Actinomadura rubra，是一种抗原虫剂，用于阻止球虫病，兽用。	Cancers (Basel),2019, 11(6)
S5093	Rafoxanide Rafoxanide (Disalan, Ranide, Flukanide, Bovanide)是一类N-水杨酰苯胺，被用作驱虫剂，在治疗和控制动物体内吸虫感染中有效。
S5092	Febantel Febantel (Rintal, Combotel, Oratel, Bay Vh 5757, Negabot Plus) 是一种前体药物，可代谢成为fenbendazole和oxfendazole，它们是活性驱虫剂。
S5557	Aklomide Aklomide (2-Chloro-4-nitrobenzamide) is a coccidiostat and used to fight disease, parasites and insects that infest poultry.
S0467	Emodepside Emodepside (QHT06, BAY 44-4400, PF 1022-221) 是一种PF1022A的半合成衍生物，是一种具有广谱的驱虫活性的环八肽。 Emodepside 可激活 Ca-dependent SLO-1-like K channels。
S4389	Bephenium Hydroxynaphthoate Bephenium 是一种 B-type Acetylcholine receptor (AChR) 的激活剂。Bephenium 可选择性地激活由Hco-UNC-29.1，Hco-UNC-38，Hco-UNC-63，Hco-ACR-8亚基组成的Hco-L-AChR1亚型。Bephenium hydroxynaphthoate 是一种驱虫药，以前用于治疗钩虫感染和蛔虫病。
S4564	Diethylcarbamazine citrate Diethylcarbamazine citrate是丝虫微丝蚴中花生四烯酸代谢的抑制剂，对几种寄生虫高度特异，不含任何有毒金属元素。
S4999	Avermectin B1 Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.
S5247	Selamectin Selamectin (UK-124114) is a novel macrocyclic lactone of the avermectin class. It paralyses and/or kills a wide range of invertebrate parasites through interference with their chloride channel conductance causing disruption of normal neurotransmission and has adulticidal, ovicidal and larvicidal activity against fleas.

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抑制剂选择性比较

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