Dihydrotestosterone (DHT)

目录号:S4757 别名: androstanolone, stanolone, 5α-DHT 中文名称:双氢睾酮

仅限科研使用

Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT)是一种内源性的雄激素性类固醇和激素,是雄激素受体的激动剂,其亲和力比睾酮高2-3倍,诱导雄激素受体信号的效力比睾酮高3倍。

Dihydrotestosterone (DHT) Chemical Structure

CAS: 521-18-6

规格 价格 库存 购买数量
10mM (1mL in DMSO) RMB 1367.81 现货
RMB 1286.81 现货
RMB 3030.86 现货
大包装 有超大折扣

今日订购,明日送达 全国免运费 分装免费 分装成小规格产品(单支最小为1mg)
如1支10mg产品可分装为10支1mg产品

全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用Selleck生产的Dihydrotestosterone (DHT)发表文献17篇:

产品安全说明书

Androgen Receptor抑制剂选择性比较

相关Androgen Receptor产品

生物活性

产品描述 Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT)是一种内源性的雄激素性类固醇和激素,是雄激素受体的激动剂,其亲和力比睾酮高2-3倍,诱导雄激素受体信号的效力比睾酮高3倍。
靶点
Androgen Receptor [1]
体外研究

在雄激素受体阳性的膀胱癌UMUC3和TCC-SUP细胞中,dihydrotestosterone (DHT)可在mRNA和蛋白水平上增加EGFR和ERBB2的表达。在AR阳性细胞中,DHT还可上调EGFR磷酸化水平及其下游蛋白AKT(pAKT)和ERK1/2(pERK)的磷酸化水平[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CV-1 cell M{fnU2Z2dmO2aX;uJIF{e2G7 NXHiXpVPSWexbnnzeIlkKGGldHn2bZR6KCiHQ{WwLUBi\2GrboP0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEXi1zIHPlcIwtKEWFNUC9NE4xODZizszN NXzOeoM5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxOUi3NVU{PCd-OUi3NVU{PDxxYU6=
MDA-MB-453 cell MlyzSpVv[3Srb36gZZN{[Xl? M4i0VmRqe3CuYXPlcYVvfCCxZjDbN2heTEiWIH\yc40hcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKE2GQT3NRk01PTNiY3XscJMh[nlid3jvcIUh[2WubDDy[YNmeHSxcjDibY5lcW6pIHHzd4F6NCCNaU2wMlAxODJizszN NXjMcFVIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewN|QyOTdpPkG3NFM1OTF5PD;hQi=>
HepG2 cell NV3hb3U6TnWwY4Tpc44h[XO|YYm= NF7HWotC[3Srdnn0fUBi\2GrboP0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBJ\XCJMjDj[YxteyCjc4Pld5Nm\CCjczDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYXP0bZZifGmxbjygTWM2OD1yLkCxPFIh|ryP M1PJOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUS5PFY3Lz5zN{G0PVg3PjxxYU6=
MDA453 cell NH7iZXlHfW6ldHnvckBie3OjeR?= MVfEbZNxdGGlZX3lcpQhd2ZiW{PIYWRJXCCocn;tJIh2dWGwIFHSJIlvKE2GQUS1N{Bk\WyuczygT4k:OC5yMEOg{txO MoPvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOEGxOFEoRjF5MUixNVQyRC:jPh?=
mouse C2C12 cell NH7IbFZHfW6ldHnvckBie3OjeR?= Ml7oRYdwdmm|dDDhZ5Rqfmm2eTDheEBz[XRiQWKgeJJidnOoZXP0[YQhcW5ibX;1d4UhSzKFMUKgZ4VtdHNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVA:OC5yMkig{txO MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG0NUc,OTdzOEGxOFE9N2F-
monkey COS7 cell M1LidmZ2dmO2aX;uJIF{e2G7 M1H3SGJqdmSrbnegZYZncW6rdImgeI8hcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKG2xbnvlfUBEV1N5IHPlcIx{KGK7IIfoc4xmKGOnbHygZolv\GmwZzDhd5NigSxiS3m9NE4xODB{IN88US=> MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDR2MkmxNkc,OTh2NEK5NVI9N2F-
CHO cell NE\iN3pHfW6ldHnvckBie3OjeR?= NHjNW3JC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHRIWjViZYjwdoV{e2WmIHnuJGNJVyClZXzsd{BjgSCudXPp[oVz[XOnIHHzd4F6NCCHQ{WwQVQvPDlizszN Mom0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh|MEeyPVQoRjF6M{C3Nlk1RC:jPh?=
COS7 cell NWK0PJVPTnWwY4Tpc44h[XO|YYm= NWrRV2NPSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBYPzRzQzDteZRidnRiZYjwdoV{e2WmIHnuJGNQWzdiY3XscJMh[XO|ZYPz[YQh[XNibIXjbYZmemG|ZTDhZ5Rqfmm2eTDh[pRmeiB{NDDodpMh[nlicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1yLkCxNkDPxE1? M13GVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEm0Nlc6Lz5{MkC5OFI4QTxxYU6=
COS7 cell MX;GeY5kfGmxbjDhd5NigQ>? MXzB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IGS4O|dCKG23dHHueEBmgHC{ZYPz[YQhcW5iQ1;TO{Bk\WyuczDhd5Nme3OnZDDhd{BtfWOrZnXyZZNmKGGldHn2bZR6KGGodHXyJFI1KGi{czDifUBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvODF3IN88US=> NGfofZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC5OFI4QSd-MkKwPVQzPzl:L3G+
COS7 cell NFPnRo5HfW6ldHnvckBie3OjeR?= M2LNcWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEORU{egZ4VtdHNiYYPz[ZN{\WRiYYOgcJVkcW[ncnHz[UBi[3Srdnn0fUBi\nSncjCyOEBpenNiYomgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2wMlAxPjJizszN M1\zO|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEm0Nlc6Lz5{MkC5OFI4QTxxYU6=
LNCaP-hr cell MonvSpVv[3Srb36gZZN{[Xl? NHHuZ4c{KGSjeYO= NHzOdotC\2:waYP0JIFkfGm4aYT5JIF1KEGwZILv[4VvKHKnY3XweI9zKFR6N{fBJI12fGGwdDDpckBpfW2jbjDMUmNiWC2qcjDj[YxteyCjc4Pld5Nm\CCjczDwdo9{fGG2ZTDzdIVkcW[rYzDhcpRq\2WwIIPlZ5JmfGmxbjDt[YF{fXKnZDDh[pRmeiB|IHThfZMh[nliZX76fY1mNWmvbYXuc4F{e2G7LDDFR|UxRTBwMEG1JO69VQ>? NY\BPVN5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPVk1PzdpPkKzNVk6PDd5PD;hQi=>
LNCaP-hr cell M4XIOWZ2dmO2aX;uJIF{e2G7 Ml\oN{Bl[Xm| NEL5dFRC\2:waYP0JIFkfGm4aYT5JIF1KHerbHSgeJlx\SCDbnTyc4dmdiC{ZXPldJRweiCrbjDoeY1idiCOTlPhVE1peiClZXzsd{Bie3Onc4Pl[EBieyCycn;zeIF1\SC|cHXjbYZq[yCjboTp[4VvKHOnY4LleIlwdiCvZXHzeZJm\CCjZoTldkA{KGSjeYOgZpkh\W68eX3lMYludXWwb3Hzd4F6NCCHQ{WwQVAvODB4MjFOwG0> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF7OUS3O{c,OjNzOUm0O|c9N2F-
HEK293 cell NH7YV|ZHfW6ldHnvckBie3OjeR?= M2jRW2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEiHS{K5N{Bk\WyuczDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5zODDuUS=> MlXQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|MEW2PFgoRjJ3M{C1Olg5RC:jPh?=
COS M{C5cWZ2dmO2aX;uJIF{e2G7 NGnQOXdDcW6maX7nJIFn\mmwaYT5JIFo[Wmwc4SgRY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW|c3XkJGNQWyClZXzsd{whU2liPTCwMlAxOiEQvF2u MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDdzNUO0K|46QDdzNUO0QE9iRg>?
COS-1 M2HqdWZ2dmO2aX;uJIF{e2G7 NFnFUWtDcW6maX7nJIFn\mmwaYT5JIZweiCqdX3hckBCdmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ1;TMVEh[2WubIOsJGtqKD1iMD6wNFMh|ryPLh?= MoPmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTl{NUeyOUc,QTl{NUeyOVww[T5?
CV-1 NH3rPJlHfW6ldHnvckBie3OjeR?= M3LwPWFod26rc4SgZYN1cX[rdImgZYdicW6|dDDIeY1idiCDbnTyc4dmdiC{ZXPldJRweiCneIDy[ZN{\WRiaX6gR3YuOSClZXzsd{whTUN3MDC9JFAvODB3IN88UU4> M1HMRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl7MkW3NlUoRjl7MkW3NlU9N2F-
COS NXW5bml6TnWwY4Tpc44h[XO|YYm= Ml;iTY4hfmm2cn:gZolv\GmwZzDh[oZqdmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjD0doFve2[nY4Tl[EBqdnSxIFPPV{Bk\Wyucz6sJGlEPTBiPTCwMlAxPCEQvF2u MmPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB{M{C2NlgoRjFyMkOwOlI5RC:jPh?=
CV-1 MnLmSpVv[3Srb36gZZN{[Xl? MVfJckB3cXS{bzDh[49vcXO2aXOgZYN1cX[rdImgZYdicW6|dDDoeY1idiCjbnTyc4dmdiC{ZXPldJRweiC3c3nu[{Bkd3S{YX7z[oVkfGmxbjDhd5NigSCrbjDDWk0yKGOnbHzzMkwhTUN3MDC9JFAvODB4IN88UU4> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yODJ|ME[yPEc,OTB{M{C2Nlg9N2F-
CV-1 MVXGeY5kfGmxbjDhd5NigQ>? MYjB[49vcXO2IHHjeIl3cXS7IITvJJRp\SCqdX3hckBidmS{b3flckBz\WOncITvdkApcEGUKTDpckBEXi1zIHPlcIx{NCCHQ{WwJF0hOC5yME[g{txONg>? Mlq2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB|NEC2NlQoRjFyM{SwOlI1RC:jPh?=
CV1 MYHGeY5kfGmxbjDhd5NigQ>? MlPSRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDpckBEXjFiY3XscJMhdWWjc4Xy[YQh[XNic4TpcZVt[XSrb36gc4YhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIFkfGm4aYT5JIJ6KGOxdILhcpNn\WO2aX;uJIF{e2G7LDDFR|UxKD1iMD6wNFUyKM7:TT6= NF7RbpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{CzOFEyPyd-MUewN|QyOTd:L3G+
CV1 NHjUOFNHfW6ldHnvckBie3OjeR?= NETJcVNDcW6maX7nJIFn\mmwaYT5JJRwKGi3bXHuJIFv\HKxZ3XuJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCFVkGgZ4VtdHNuIFvpJF0hOC5yMECyJO69VS5? NXnGVXdqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyOVc5OzhpPkG3NlU4QDN6PD;hQi=>
CV1 MmnKSpVv[3Srb36gZZN{[Xl? NXfoUZpYSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ2[xJINmdGy|LDDFR|UxKD1iMD6wNFUyKM7:TT6= Mne3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{NUe4N|goRjF5MkW3PFM5RC:jPh?=
MDA-MB-453 NHPlc5hHfW6ldHnvckBie3OjeR?= Mn7DSIl{eGyjY3Xt[Y51KG:oIGuzTH1FUFRiZoLvcUBpfW2jbjDBVkBmgHC{ZYPz[YQhcW5iTVTBMW1DNTR3MzDj[YxteyxiS3mgQUAxNjByMEOg{txONg>? NUm3[ZJPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N|kyOTJpPkG3OFM6OTF{PD;hQi=>
CV1 NYPzU5NbTnWwY4Tpc44h[XO|YYm= M1v0OmFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW|c3XkJIlvKEOYMTDj[YxteyCkeTD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDhd5NigSxiRVO1NEA:KDBwMEC1O{DPxE1w M3XOUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NEO5NVEzLz5zN{SzPVEyOjxxYU6=
CV1 NYfOPJFRTnWwY4Tpc44h[XO|YYm= MXTB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEXjFiY3XscJMh[nlidILhcpNkemmydHnvcoFtKGGldHn2ZZRqd25iYYPzZZktKEWFNUCgQUAxNjByNUeg{txONg>? MmrqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd5MEO5N|goRjF5N{CzPVM5RC:jPh?=
MDA-MB-453 MYrGeY5kfGmxbjDhd5NigQ>? M1rmOmRqe3CuYXPlcYVvfCCxZjDbN2heTEiWIH\yc40hcHWvYX6gRY5lem:pZX6gdoVk\XC2b4KgbY4hcHWvYX6gUWRCNU2ELUS1N{Bk\WyuczygT4khRSByLkCwNFkh|ryPLh?= NILmTmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOESwNFQ6QSd-MUi0NFA1QTl:L3G+
CV1 MnzzSpVv[3Srb36gZZN{[Xl? MUDB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHnuJGNXOSClZXzsd{BjgSC2cnHud4NzcXC2aX;uZYwh[WO2aY\heIlwdiCjc4PhfUwhTUN3MDC9JFAvODB3NzFOwG0v MoflQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2MEC0PVkoRjF6NECwOFk6RC:jPh?=
Saos2 NEWyPYdHfW6ldHnvckBie3OjeR?= M1;rW2FkfGm4aYT5JIF1KGGwZILv[4VvKHKnY3XweI9zKGmwIHj1cYFvKFOjb4OyJINmdGy|IHHzd4V{e2WmIHHzJGlNPiC{ZYDy[ZN{cW:wLDDJR|UxKD1iMD6wNFAxPSEQvF2u NHHHSpQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES0NlkyOid-MUi0OFI6OTJ:L3G+
CV1 NHr0U|JHfW6ldHnvckBie3OjeR?= NFP5NIpC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJIFv\HKxZ3XuJJJm[2WydH;yJIFnemmlYX6g[5Jm\W5ibX;ub4V6KEOYMTDj[YxteyCkeTDjc5Rz[W6|ZnXjeIlwdiCjc4PhfUwhTUN3MDC9JFAvODB3MTFOwG0v M1PHVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NESyPVEzLz5zOES0NlkyOjxxYU6=
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MDA-kb2 NU\1OWp7TnWwY4Tpc44h[XO|YYm= MnPtRYdwdmm|dDDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDNSGEuc2J{IHPlcIx{KGG|c3Xzd4VlKGG|IIP0bY12dGG2aX;uJI9nKGy3Y3nm[ZJie2ViYXP0bZZqfHliYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{G1NEA:KDBwMECwOUDPxE1w MlzYQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3OUKyOFUoRjF7NUmyNlQ2RC:jPh?=
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Shionogi NWLTRYZUTnWwY4Tpc44h[XO|YYm= MX6xNEBxVQ>? M2Llemlv\HWldHnvckBw\iCycn;sbYZmemG2aX;uJI9nKG2xdYPlJHNpcW:wb3fpJINmdGy|IHH0JFExKHCP MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzdzMUi1OUc,OTd5MUG4OVU9N2F-
MCF7 NWLDbGNCTnWwY4Tpc44h[XO|YYm= M{LZOFMxKHWP M{nVflI1KGi{cx?= MknpRY51[WexbnnzeEBi[3Srdnn0fUBifCCDUjDpckBpfW2jbjDNR2Y4KGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDBVkBt\X[nbDDheEA{OCC3TTDh[pRmeiB{NDDodpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nzJJJmdGG2aY\lJJRwKGOxboTyc4w> MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjBzNEe1NUc,OjJyMUS3OVE9N2F-
Assay
Methods Test Index PMID
Western blot Cyclin D1 / Cyclin D2 / Cyclin D3 / Cyclin E2 / Cyclin A1 / AR p-CDK2 / CDK2 / CDK4 / CDK6 / CDKN1A / p-RB / RB p27 / p-p27 AR / PP1 26372468 22139837 26636645
Immunofluorescence FOXO1 / p27 AKT(S473) / PKCα(S657) 22139837
体内研究 DHT可减轻SOD1-G93A小鼠的肌萎缩症状并增加其体重。DHT的处理增加了肌肉中胰岛素样生长因子1的表达,通过逆向轴浆运输发挥其肌肉营养性和神经营养性效果。其处理还减缓了神经肌肉接头处的去神经支配作用、以及减少轴突和运动神经元的丢失。DHT处理的SOD1-G93A小鼠改善了运动行为,生命期限也有所延长[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

细胞实验:

[1]

  • Cell lines: 膀胱癌细胞
  • Concentrations: 1 nM
  • Incubation Time: 24 h
  • Method:

    对铺于24孔板的、达到50%-60%融合率的细胞进行MMTV-luc报告质粒和PRL-TK-luc质粒共转染实验。转染完6小时后,将培养基替换为含活性炭处理胎牛血清的培养基,加入或不加入配体(DHT、HF或同时加入),处理24小时。收集细胞、溶解、进行荧光素酶活性检测。

动物实验:

[2]

  • Animal Models: SOD1-G93A mutant mice with the congenic C57BL/6J background
  • Dosages: 5 mg
  • Administration: silastic implant

溶解度(25°C)

体外

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 290.44
化学式

C19H30O2

CAS号 521-18-6
储存条件 3年 -20°C 粉状
2年 -80°C 溶于溶剂

动物体内配方计算器(澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)

mg/kg g μL

第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)

% DMSO % % Tween 80 % ddH2O
%DMSO %

计算结果:

工作液浓度: mg/ml;

DMSO母液配制方法: mg 药物溶于μL DMSO溶液(母液浓度mg/mL,:如该浓度超过该批次药物DMSO溶解度,请先联系Selleck);

体内配方配制方法:μL DMSO母液,加入μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入μL ddH2O,混匀澄清。

体内配方配制方法:μL DMSO母液,加入μL Corn oil,混匀澄清。

注意:1. 首先保证母液是澄清的;
2.一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量 浓度 体积 分子量

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04989972 Withdrawn Drug: PSIL428|Dietary Supplement: Oyster mushroom Anxiety and Depression Wake Network Inc.|Professor Roger Gibson Section of Psychiatry Faculty of Medical Sciences UWI September 15 2022 Phase 2
NCT05033444 Recruiting Drug: PRV-002|Drug: Placebo Traumatic Brain Injury (TBI) Odyssey Group International Inc.|Avance Clinical Pty Ltd. September 17 2021 Phase 1
NCT05042895 Recruiting Procedure: Group A|Procedure: Group B Infertility Woman''s Health University Hospital Egypt August 20 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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