Dihydrotestosterone (DHT)

For research use only. Not for use in humans.

目录号：S4757 别名： androstanolone, stanolone, 5α-DHT 中文名称：双氢睾酮

Dihydrotestosterone (DHT) Chemical Structure

CAS No. 521-18-6

Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT)是一种内源性的雄激素性类固醇和激素，是雄激素受体的激动剂，其亲和力比睾酮高2-3倍，诱导雄激素受体信号的效力比睾酮高3倍。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 1367.81	现货
25mg	RMB 1286.81	现货
100mg	RMB 3030.86	现货
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客户使用Selleck生产的Dihydrotestosterone (DHT)发表文献14篇：

J Med Chem, 2022, 65(3):2507-2521

PubMed: 35077161 ( click the link to review the publication )

Life Sci Alliance, 2022, 5(4)e202101116

PubMed: 35110354 ( click the link to review the publication )

J Oncol, 2022, 2022:6085948

PubMed: 35444697 ( click the link to review the publication )

Arch Biochem Biophys, 2022, 715:109094

PubMed: 34813774 ( click the link to review the publication )

Gene, 2022, 819:146264

PubMed: 35114283 ( click the link to review the publication )

Differentiation, 2022, 123:42-49

PubMed: 35030420 ( click the link to review the publication )

Environ Health Perspect, 2021, 129(4):47010

PubMed: 33851871 ( click the link to review the publication )

Sci Rep, 2021, 11(1):14880

PubMed: 34290270 ( click the link to review the publication )

Prostate, 2021, 81(9):508-520

PubMed: 33955576 ( click the link to review the publication )

Hum Reprod, 2020, 6 pii: deaa077

PubMed: 32372097 ( click the link to review the publication )

Prostate, 2020, 80(9):674-686

PubMed: 32294305 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 21;526(1):267-272

PubMed: 32209261 ( click the link to review the publication )

Onco Targets Ther, 2020, 13:9821-9837

PubMed: 33061460 ( click the link to review the publication )

Circulation, 2019, 140(13):1070-1080

PubMed: 31378084 ( click the link to review the publication )

产品安全说明书

Androgen Receptor抑制剂选择性比较

生物活性

产品描述

靶点

Androgen Receptor ^[1]
()

体外研究

在雄激素受体阳性的膀胱癌UMUC3和TCC-SUP细胞中，dihydrotestosterone (DHT)可在mRNA和蛋白水平上增加EGFR和ERBB2的表达。在AR阳性细胞中，DHT还可上调EGFR磷酸化水平及其下游蛋白AKT（pAKT）和ERK1/2(pERK)的磷酸化水平^[1]。

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
CV-1 cell	MYTGeY5kfGmxbjDhd5NigQ>?			NHTy[mdC\2:waYP0bYMh[WO2aY\peJkhMEWFNUCpJIFo[Wmwc4SgbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGNXNTFiY3XscEwhTUN3ME2wMlAxPiEQvF2=	MnvDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTh5MUWzOEc,QTh5MUWzOFww[T5?
MDA-MB-453 cell	NW[2bIVuTnWwY4Tpc44h[XO\|YYm=			NILw[ZRFcXOybHHj[Y1mdnRib3[gX\|NJZUSKVDDmdo9uKGi3bXHuJIFv\HKxZ3XuJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCPRFGtUWIuPDV\|IHPlcIx{KGK7IIfoc4xmKGOnbHygdoVk\XC2b4KgZolv\GmwZzDhd5NigSxiS3m9NE4xODB{IN88US=>	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB\|NEGxO{c,OTdyM{SxNVc9N2F-
HepG2 cell	MlvlSpVv[3Srb36gZZN{[Xl?			NWTQV2JqSWO2aY\peJkh[WejaX7zeEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hUGWyR{KgZ4VtdHNiYYPz[ZN{\WRiYYOgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHjeIl3[XSrb36sJGlEPTB;MD6wNVgzKM7:TR?=	NYDjRXVWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexOFk5PjZpPkG3NVQ6QDZ4PD;hQi=>
MDA453 cell	M1XWXmZ2dmO2aX;uJIF{e2G7			NVrwZmRZTGm\|cHzhZ4Vu\W62IH;mJHs{UF2GSGSg[pJwdSCqdX3hckBCWiCrbjDNSGE1PTNiY3XscJMtKEurPUCuNFA{KM7:TR?=	NYLifnFuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPFEyPDFpPkG3NVgyOTRzPD;hQi=>
mouse C2C12 cell	NWTscFB2TnWwY4Tpc44h[XO\|YYm=			NGjnXohC\2:waYP0JIFkfGm4aYT5JIF1KHKjdDDBVkB1emGwc3\lZ5Rm\CCrbjDtc5V{\SCFMlOxNkBk\WyuczDifUBtfWOrZnXyZZNmKHKncH;yeIVzKHS{YX7zZYN1cX[jdHnvckBie3OjeTygSWM2OD1yLkCyPEDPxE1?	M3y5T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUixNVQyLz5zN{G4NVE1OTxxYU6=
monkey COS7 cell	M33GTGZ2dmO2aX;uJIF{e2G7			NWGxNXpKSmmwZHnu[{Bi\m[rbnn0fUB1dyCqdX3hckBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5ibX;ub4V6KEORU{egZ4VtdHNiYomge4hwdGViY3XscEBjcW6maX7nJIF{e2G7LDDLbV0xNjByMEKg{txO	NVS3fVNFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OFI6OTJpPkG4OFQzQTF{PD;hQi=>
CHO cell	MYTGeY5kfGmxbjDhd5NigQ>?			MnPURYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDUS3I2KGW6cILld5Nm\CCrbjDDTG8h[2WubIOgZpkhdHWlaX\ldoF{\SCjc4PhfUwhTUN3ME20MlQ6KM7:TR?=	NV3z[GdURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUizNFczQTRpPkG4N\|A4Ojl2PD;hQi=>
COS7 cell	MWfGeY5kfGmxbjDhd5NigQ>?			MkXBRYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDXO\|QySyCvdYThcpQh\XiycnXzd4VlKGmwIFPPV\|ch[2WubIOgZZN{\XO\|ZXSgZZMhdHWlaX\ldoF{\SCjY4Tpeol1gSCjZoTldkAzPCCqcoOgZpkhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjBzMjFOwG0>	NFS0THo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkC5OFI4QSd-MkKwPVQzPzl:L3G+
COS7 cell	MWDGeY5kfGmxbjDhd5NigQ>?			NULnPGtrSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBVQDd5QTDteZRidnRiZYjwdoV{e2WmIHnuJGNQWzdiY3XscJMh[XO\|ZYPz[YQh[XNibIXjbYZmemG\|ZTDhZ5Rqfmm2eTDh[pRmeiB{NDDodpMh[nlicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1yLkCxOUDPxE1?	M1\GTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEm0Nlc6Lz5{MkC5OFI4QTxxYU6=
COS7 cell	NXfScHBjTnWwY4Tpc44h[XO\|YYm=			MmnKRYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hS0:VNzDj[YxteyCjc4Pld5Nm\CCjczDseYNq\mW{YYPlJIFkfGm4aYT5JIFnfGW{IEK0JIhzeyCkeTDy[ZBwenSncjDn[Y5mKGG\|c3H5MEBGSzVyPUCuNFA3OiEQvF2=	M1:w[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEm0Nlc6Lz5{MkC5OFI4QTxxYU6=
LNCaP-hr cell	MUfGeY5kfGmxbjDhd5NigQ>?		Mn;2N{Bl[Xm\|	M1XjSmFod26rc4SgZYN1cX[rdImgZZQhSW6mcn;n[Y4hemWlZYD0c5IhXDh5N1GgcZV1[W62IHnuJIh2dWGwIFzOR4FRNWi{IHPlcIx{KGG\|c3Xzd4VlKGG\|IIDyc5N1[XSnIIPw[YNq\mmlIHHueIlo\W5ic3XjdoV1cW:wIH3lZZN2emWmIHHmeIVzKDNiZHH5d{BjgSCnbor5cYUucW2vdX7vZZN{[XluIFXDOVA:OC5yMUWg{txO	NUf3RphJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPVk1PzdpPkKzNVk6PDd5PD;hQi=>
LNCaP-hr cell	NWDYZWVqTnWwY4Tpc44h[XO\|YYm=		MojYN{Bl[Xm\|	M4XUSWFod26rc4SgZYN1cX[rdImgZZQhf2muZDD0fZBmKEGwZILv[4VvKHKnY3XweI9zKGmwIHj1cYFvKEyQQ3HQMYhzKGOnbHzzJIF{e2W\|c3XkJIF{KHC{b4P0ZZRmKHOyZXPp[olkKGGwdHnn[Y4he2WlcnX0bY9vKG2nYYP1doVlKGGodHXyJFMh\GG7czDifUBmdnq7bXWtbY1ufW6xYYPzZZktKEWFNUC9NE4xODZ{IN88US=>	M3\CcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUm5OFc4Lz5{M{G5PVQ4PzxxYU6=
HEK293 cell	M3W4PGZ2dmO2aX;uJIF{e2G7			Mlj5RYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hUEWNMkmzJINmdGy\|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjF6IH7N	NHnI[GE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUOwOVY5QCd-MkWzNFU3QDh:L3G+
COS	NVrGSIRuTnWwY4Tpc44h[XO\|YYm=			Mne4Rolv\GmwZzDh[oZqdmm2eTDh[4FqdnO2IFHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDDU3Mh[2WubIOsJGtqKD1iMD6wNFIh\|ryPLh?=	NE\VV4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OEexOVM1Lz57OEexOVM1RC:jPh?=
COS-1	M2SxV2Z2dmO2aX;uJIF{e2G7			MlPYRolv\GmwZzDh[oZqdmm2eTDmc5IhcHWvYX6gRY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW\|c3XkJIlvKEORUz2xJINmdGy\|LDDLbUA:KDBwMECzJO69VS5?	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QTJ3N{K1K\|46QTJ3N{K1QE9iRg>?
CV-1	MVTGeY5kfGmxbjDhd5NigQ>?			NWDn[XpMSWexbnnzeEBi[3Srdnn0fUBi\2GrboP0JGh2dWGwIFHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEXi1zIHPlcIx{NCCHQ{WwJF0hOC5yMEWg{txONg>?	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QTJ3N{K1K\|46QTJ3N{K1QE9iRg>?
COS	NIXyPGZHfW6ldHnvckBie3OjeR?=			NG\CRo5KdiC4aYTyc{BjcW6maX7nJIFn\mmwaYT5JIF1KGi3bXHuJIFv\HKxZ3XuJJJm[2WydH;yJJRz[W6\|ZnXjeIVlKGmwdH:gR29UKGOnbHzzMkwhUUN3MDC9JFAvODB2IN88UU4>	MnXGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB{M{C2NlgoRjFyMkOwOlI5RC:jPh?=
CV-1	NWnGe4ZwTnWwY4Tpc44h[XO\|YYm=			Mm\NTY4hfmm2cn:gZYdwdmm\|dHnjJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JidYPpcoch[2:2cnHud4Zm[3Srb36gZZN{[XliaX6gR3YuOSClZXzsd{4tKEWFNUCgQUAxNjByNjFOwG0v	Mo\TQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTB{M{C2NlgoRjFyMkOwOlI5RC:jPh?=
CV-1	Ml2xSpVv[3Srb36gZZN{[Xl?			NGPldVJC\2:waYP0JIFkfGm4aYT5JJRwKHSqZTDoeY1idiCjbnTyc4dmdiC{ZXPldJRweiBqaFHSLUBqdiCFVj2xJINmdGy\|LDDFR\|UxKD1iMD6wNFYh\|ryPLh?=	M{jjTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyM{SwOlI1Lz5zMEO0NFYzPDxxYU6=
CV1	MoPUSpVv[3Srb36gZZN{[Xl?			MnPDRYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDpckBEXjFiY3XscJMhdWWjc4Xy[YQh[XNic4TpcZVt[XSrb36gc4YhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIFkfGm4aYT5JIJ6KGOxdILhcpNn\WO2aX;uJIF{e2G7LDDFR\|UxKD1iMD6wNFUyKM7:TT6=	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzB\|NEGxO{c,OTdyM{SxNVc9N2F-
CV1	NInERpNHfW6ldHnvckBie3OjeR?=			NWHTcHM5SmmwZHnu[{Bi\m[rbnn0fUB1dyCqdX3hckBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ2[xJINmdGy\|LDDLbUA:KDBwMECwNkDPxE1w	M{XCT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MkW3PFM5Lz5zN{K1O\|g{QDxxYU6=
CV1	MoS5SpVv[3Srb36gZZN{[Xl?			NHq5SmFC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJIFv\HKxZ3XuJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCFVkGgZ4VtdHNuIFXDOVAhRSByLkCwOVEh\|ryPLh?=	NU\DeVRFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyOVc5OzhpPkG3NlU4QDN6PD;hQi=>
MDA-MB-453	MYjGeY5kfGmxbjDhd5NigQ>?			MWnEbZNxdGGlZX3lcpQhd2ZiW{PIYWRJXCCocn;tJIh2dWGwIFHSJIV5eHKnc4Pl[EBqdiCPRFGtUWIuPDV\|IHPlcIx{NCCNaTC9JFAvODByMzFOwG0v	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzR\|OUGxNkc,OTd2M{mxNVI9N2F-
CV1	MoGxSpVv[3Srb36gZZN{[Xl?			MnXWRYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hS1ZzIHPlcIx{KGK7IITyZY5{[3KrcITpc45idCCjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwJF0hOC5yMEW3JO69VS5?	NWLDelVjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N\|kyOTJpPkG3OFM6OTF{PD;hQi=>
CV1	NVvjXYgxTnWwY4Tpc44h[XO\|YYm=			NWPQZ5FNSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5iQ2[xJINmdGy\|IHL5JJRz[W6\|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJIF{e2G7LDDFR\|UxKD1iMD6wNFU4KM7:TT6=	NGP4N5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{ewN\|k{QCd-MUe3NFM6Ozh:L3G+
MDA-MB-453	Ml\WSpVv[3Srb36gZZN{[Xl?			NHnSXXdFcXOybHHj[Y1mdnRib3[gX\|NJZUSKVDDmdo9uKGi3bXHuJGFv\HKxZ3XuJJJm[2WydH;yJIlvKGi3bXHuJG1FSS2PQj20OVMh[2WubIOsJGtqKD1iMD6wNFA6KM7:TT6=	M3fxS\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NECwOFk6Lz5zOESwNFQ6QTxxYU6=
CV1	NWrROWwyTnWwY4Tpc44h[XO\|YYm=			MnvtRYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDpckBEXjFiY3XscJMh[nlidILhcpNkemmydHnvcoFtKGGldHn2ZZRqd25iYYPzZZktKEWFNUCgQUAxNjByNUeg{txONg>?	M3TK[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NECwOFk6Lz5zOESwNFQ6QTxxYU6=
Saos2	NXfOVHpQTnWwY4Tpc44h[XO\|YYm=			MUjBZ5Rqfmm2eTDheEBidmS{b3flckBz\WOncITvdkBqdiCqdX3hckBU[W:\|MjDj[YxteyCjc4Pld5Nm\CCjczDJUFYhemWycnXzd4lwdixiSVO1NEA:KDBwMECwNFUh\|ryPLh?=	NXnOTXE5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OFI6OTJpPkG4OFQzQTF{PD;hQi=>
CV1	NIPtVVRHfW6ldHnvckBie3OjeR?=			NXnZeFQ3SWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBi\nKrY3HuJIdz\WWwIH3vcotmgSCFVkGgZ4VtdHNiYomgZ491emGwc3\lZ5Rqd25iYYPzZZktKEWFNUCgQUAxNjByNUGg{txONg>?	M1;uUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NESyPVEzLz5zOES0NlkyOjxxYU6=
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MDA-kb2	MnnWSpVv[3Srb36gZZN{[Xl?			MW\B[49vcXO2IHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHnuJIh2dWGwIF3ERU1s[jJiY3XscJMh[XO\|ZYPz[YQh[XNic4TpcZVt[XSrb36gc4YhdHWlaX\ldoF{\SCjY4Tpeol1gSCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFMUWwJF0hOC5yMEC1JO69VS5?	Mn[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTl3OUKyOFUoRjF7NUmyNlQ2RC:jPh?=
MDA-MB-453	NFv1TZJHfW6ldHnvckBie3OjeR?=			M{jsUGRqe3CuYXPlcYVvfCCxZjDbN2hedWW2aInseJJq\W6xbH;u[UBnem:vIHHu[JJw\2WwIILlZ4VxfG:{IHnuJIh2dWGwIF3ERU1OSi12NUOgZ4VtdHNuIFnDOVAhRSByLkCwNUDPxE1w	NH\1[oE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[wOlg4OCd-MUm2NFY5PzB:L3G+
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Freestyle293F	M2PzPGZ2dmO2aX;uJIF{e2G7		MkDqN{BpenN?	NXyw[YkzTGm\|cHzhZ4Vu\W62IH;mJHsyPy2jbIDoZU1u\XSqeXytN2heNW2rYn;s[ZJwdmViZoLvcUBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDUPFc4SSCvdYThcpQh\XiycnXzd4VlKGmwIFjFT\|I6OyCmZYLpeoVlKE[{ZXXTeJlt\TJ7M1[gZ4VtdHNiYX\0[ZIhOyCqcoOsJGlEPTBiPTCwMlAxOjZizszNMi=>	MlP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOUSyO\|koRjJ{MEm0Nlc6RC:jPh?=
HeLa	M2nLNWZ2dmO2aX;uJIF{e2G7			MVHUdoFve2GldHn2ZZRqd25ib3[gbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JidILhcpNn\WO2ZXSgbY4hcHWvYX6gTIVN[SClZXzsd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO\|YYmsJGFkfGm4aYT5JF0hOC5yMEig{txONg>?	M1LNT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OEm3OlEyLz5{Mki5O\|YyOTxxYU6=
HeLa	MWLGeY5kfGmxbjDhd5NigQ>?			NUS3OldUWGG{dHnhcEBi\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJIFv\HKxZ3XuJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCKZVzhJINmdGy\|IHPvMYV5eHKnc4PpcochSVKHIHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDiZZNm\CC2cnHud4FkfGm4YYTpc44h[XO\|YYmsJGFkfGm4aYT5JF0hOC5yMEig{txONg>?	NHzEUGw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm1O\|k1Pyd-MkK5OVc6PDd:L3G+
Freestyle293F	NHTKNlNHfW6ldHnvckBie3OjeR?=			NIrmUGVKdmirYnn0bY9vKG:oIIfpcIQhfHmyZTDBcoRzd2enbjDy[YNmeHSxcjCoeY5sdm:5bjDvdolocW5rIHX4dJJme3OnZDDpckBHemWnc4T5cIUzQTOIIHPlcIx{NCCLQ{WwJF0hOC5yMEKxJO69VS5?	NVTic5l{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOxPVk1PzdpPkKzNVk6PDd5PD;hQi=>
Freestyle293F	NHPMcGtHfW6ldHnvckBie3OjeR?=			MnTpTY5pcWKrdHnvckBw\iCDbnTyc4dmdiC{ZXPldJRweiCWOEe3RUBufXSjboSgLJVvc26xd36gc5Jq\2mwKTDlfJBz\XO\|ZXSgbY4hTnKnZYP0fYxmOjl\|RjDj[YxteyxiSVO1NEA:KDBwMECyOkDPxE1w	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF7OUS3O{c,OjNzOUm0O\|c9N2F-
COS7	NEjzWFBHfW6ldHnvckBie3OjeR?=		NECyNpkzKGi{cx?=	MV3EbZNxdGGlZX3lcpQhd2ZiW{PIYUBePWGucHjhMWRJXCCocn;tJI1wfXOnIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBud26tZYmgR29UPyClZXzsd{Bi\nSncjCyJIhzeyCkeTDzZ4lvfGmubHH0bY9vKGOxdX70bY5oKGGwYXz5d4l{NCCLQ{WwJF0hOC5yMEGg{txONg>?	NWDJOJRPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1Nlc5OTZpPkKzOVI4QDF4PD;hQi=>
C2C12	NUH3b3dXTnWwY4Tpc44h[XO\|YYm=		NF3ZTpA2KGSjeYO=	MkPwRYdwdmm\|dDDhZ5Rqfmm2eTDheEBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5ibX;1d4UhSzKFMUKgZ4VtdHNiYYPz[ZN{\WRiYYOgc5N1\W:kbHHzeEBlcW[oZYLlcpRq[XSrb36gZYZ1\XJiNTDkZZl{NCCHQ{WwJF0hOC5yMECwOUDPxE1w	NWXucGtrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFAzQTBpPkK0PVAxOjlyPD;hQi=>
C2C12	NH7GcFlHfW6ldHnvckBie3OjeR?=			NV2xd2xZSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5ibX;1d4UhSzKFMUKgZ4VtdHNiYomgZY5lem:pZX6td5Bm[2moaXOgdoV{eG:wc3Wg[YxmdWWwdD3kdol3\W5ibIXjbYZmemG\|ZTDy[ZBwenSncjDn[Y5mKGG\|c3H5MEBGSzVyIE2gNE4xODBzMzFOwG0v	NFfOS489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUGyNVk3PCd-MkWxNlE6PjR:L3G+
COS7	M3PuN2Z2dmO2aX;uJIF{e2G7		MorzNlQhcHK\|	MVfB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIFHSJIV5eHKnc4Pl[EBqdiCDZoLpZ4FvKGe{ZXXuJI1wdmuneTDDU3M4KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUCgQUAxNjByMzFOwG0v	NEiwWpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OES1OFg1QSd-Mki0OVQ5PDl:L3G+
Shionogi	NFezZ4pHfW6ldHnvckBie3OjeR?=	M2f2flExKHCP		MXLJcoR2[3Srb36gc4YheHKxbHnm[ZJifGmxbjDv[kBud3W\|ZTDTbIlwdm:paTDj[YxteyCjdDCxNEBxVQ>?	NGXFbHE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{exNVg2PSd-MUe3NVE5PTV:L3G+
MCF7	NED2VlhHfW6ldHnvckBie3OjeR?=	MkDGN\|AhfU1?	MmDrNlQhcHK\|	MX7BcpRi\2:waYP0JIFkfGm4aYT5JIF1KEGUIHnuJIh2dWGwIF3DSlch[2WubIOgZZN{\XO\|ZXSgZZMhemWmdXP0bY9vKGmwIFHSJIxmfmWuIHH0JFMxKHWPIHHmeIVzKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm\|aYOgdoVt[XSrdnWgeI8h[2:wdILvcC=>	M3PI[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEG0O\|UyLz5{MkCxOFc2OTxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Cyclin D1 / Cyclin D2 / Cyclin D3 / Cyclin E2 / Cyclin A1 / AR; PubMed: 26372468 PLoS One HPr-1AR cells were treated with 10 nM DHT or vehicle control for 24–48 hours (h), and immunoblot analysis of cell lysates reveals that cyclin D1 and D2 protein expression decreased substantially with DHT treatment compared to vehicle. p-CDK2 / CDK2 / CDK4 / CDK6 / CDKN1A / p-RB / RB ; PubMed: 26372468 PLoS One HPr-1AR cells were treated with 10 nM DHT or vehicle control for 24–48 hours (h). Immunoblot analysis of cell lysates reveals that CDK4 and CDK6 protein expression decreased and CDKN1A expression increased with DHT treatment compared to vehicle. CDK2 phosphorylation at threonine 160 (T160) decreased nearly 50% with androgen treatment at 24 and 48 hours, albeit not significantly, and total CDK2 protein expression remained unchanged. Relative to total RB expression, the levels of various phosphorylated forms of RB (S780 and S807/811) decreased over time with androgen treatment. p27 / p-p27 ; PubMed: 22139837 J Biol Chem CWR22Rv1 or CWR22R3 cells were stimulated with 10 nm DHT for 6 h, with the addition of MG132 during the last 2 h before harvesting. Proteins were then immunoblotted. AR / PP1 ; PubMed: 26636645 Oncotarget HeLa cells were transfected with Flag-PP1α and HA-AR and then incubated for overnight in androgen-depleted medium without or with androgen (10 nM of DHT) as indicated for blotting.	26372468 22139837 26636645
Immunofluorescence	FOXO1 / p27 ; PubMed: 22139837 J Biol Chem CWR22R3 cells cultured in medium with CDS serum were treated without/with DHT (10 nm) for 4 h. The cells were immunostained for FOXO1 and p27 and examined with a confocal microscope. AKT(S473) / PKCα(S657) ; PubMed: 22139837 J Biol Chem CWR22R3 cells cultured in medium with CDS serum were treated without/with 10 nm DHT (−/+ DHT) for 4 h. The cells were immunostained for AKT or PKCα phosphorylation and examined with a confocal microscope. Bars: 20 μm	22139837

体内研究

DHT可减轻SOD1-G93A小鼠的肌萎缩症状并增加其体重。DHT的处理增加了肌肉中胰岛素样生长因子1的表达，通过逆向轴浆运输发挥其肌肉营养性和神经营养性效果。其处理还减缓了神经肌肉接头处的去神经支配作用、以及减少轴突和运动神经元的丢失。DHT处理的SOD1-G93A小鼠改善了运动行为，生命期限也有所延长^[2]。

细胞实验： ^[1]	- 合并 Cell lines: 膀胱癌细胞 Concentrations: 1 nM Incubation Time: 24 h Method: 对铺于24孔板的、达到50%-60%融合率的细胞进行MMTV-luc报告质粒和PRL-TK-luc质粒共转染实验。转染完6小时后，将培养基替换为含活性炭处理胎牛血清的培养基，加入或不加入配体（DHT、HF或同时加入），处理24小时。收集细胞、溶解、进行荧光素酶活性检测。 (Only for Reference)
动物实验： ^[2]	- 合并 Animal Models: SOD1-G93A mutant mice with the congenic C57BL/6J background Dosages: 5 mg Administration: silastic implant (Only for Reference)

参考文献

溶解度 (25°C)

体外	DMSO	58 mg/mL (199.69 mM)
	Ethanol	58 mg/mL (199.69 mM)
	Water	Insoluble

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Dihydrotestosterone (DHT) SDF

分子量	290.44
化学式	C₁₉H₃₀O₂
CAS号	521-18-6
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	androstanolone, stanolone, 5α-DHT

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05033444	Recruiting	Drug: PRV-002\|Drug: Placebo	Traumatic Brain Injury (TBI)	Odyssey Group International Inc.\|Avance Clinical Pty Ltd.	September 17 2021	Phase 1
NCT04989972	Not yet recruiting	Drug: PSIL428\|Dietary Supplement: Oyster mushroom	Anxiety and Depression	Wake Network Inc.\|Professor Roger Gibson Section of Psychiatry Faculty of Medical Sciences UWI	September 15 2021	Phase 2
NCT05042895	Recruiting	Procedure: Group A\|Procedure: Group B	Infertility	Woman''s Health University Hospital Egypt	August 20 2021	Not Applicable

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操作手册

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研究领域

产品类型

定制您的化合物库

Dihydrotestosterone (DHT)

客户使用Selleck生产的Dihydrotestosterone (DHT)发表文献14篇：

产品安全说明书

Androgen Receptor抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Dihydrotestosterone (DHT) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

技术支持

Androgen Receptor Signaling Pathway Map

相关Androgen Receptor产品