Dihydrotestosterone (DHT)

For research use only. Not for use in humans.

目录号：S4757 别名： androstanolone, stanolone, 5α-DHT 中文名称：双氢睾酮

Dihydrotestosterone (DHT) Chemical Structure

CAS No. 521-18-6

Dihydrotestosterone (DHT, androstanolone, stanolone, 5α-DHT)是一种内源性的雄激素性类固醇和激素，是雄激素受体的激动剂，其亲和力比睾酮高2-3倍，诱导雄激素受体信号的效力比睾酮高3倍。

规格

价格

库存

购买数量

10mM (1mL in DMSO)	RMB 1367.81	现货
25mg	RMB 1286.81	现货
100mg	RMB 3030.86	现货
大包装	有超大折扣

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客户使用Selleck生产的Dihydrotestosterone (DHT)发表文献5篇：

Hum Reprod, 2020, 6 pii: deaa077

PubMed: 32372097 ( click the link to review the publication )

Prostate, 2020, 80(9):674-686

PubMed: 32294305 ( click the link to review the publication )

Biochem Biophys Res Commun, 2020, 21;526(1):267-272

PubMed: 32209261 ( click the link to review the publication )

Onco Targets Ther, 2020, 13:9821-9837

PubMed: 33061460 ( click the link to review the publication )

Circulation, 2019, 140(13):1070-1080

PubMed: 31378084 ( click the link to review the publication )

产品安全说明书

Androgen Receptor抑制剂选择性比较

生物活性

产品描述

靶点

Androgen Receptor ^[1]
()

体外研究

在雄激素受体阳性的膀胱癌UMUC3和TCC-SUP细胞中，dihydrotestosterone (DHT)可在mRNA和蛋白水平上增加EGFR和ERBB2的表达。在AR阳性细胞中，DHT还可上调EGFR磷酸化水平及其下游蛋白AKT（pAKT）和ERK1/2(pERK)的磷酸化水平^[1]。

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
CV-1 cell	Ml[xSpVv[3Srb36gZZN{[Xl?			NECxOVNC\2:waYP0bYMh[WO2aY\peJkhMEWFNUCpJIFo[Wmwc4SgbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGNXNTFiY3XscEwhTUN3ME2wMlAxPiEQvF2=	Mo\aQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwQTh5MUWzOEc,QTh5MUWzOFww[T5?
MDA-MB-453 cell	NHrvdoVHfW6ldHnvckBie3OjeR?=			MVnEbZNxdGGlZX3lcpQhd2ZiW{PIYWRJXCCocn;tJIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHX4dJJme3OnZDDpckBOTEFvTVKtOFU{KGOnbHzzJIJ6KHeqb3zlJINmdGxicnXj[ZB1d3JiYnnu[Ilv\yCjc4PhfUwhU2l;MD6wNFAzKM7:TR?=	MlWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdyM{SxNVcoRjF5MEO0NVE4RC:jPh?=
HepG2 cell	NULyUphZTnWwY4Tpc44h[XO\|YYm=			M2PoTWFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iYX7kdo9o\W5icnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGhmeEd{IHPlcIx{KGG\|c3Xzd4VlKGG\|IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjY4TpeoF1cW:wLDDJR\|UxRTBwMEG4NkDPxE1?	M3y2flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUS5PFY3Lz5zN{G0PVg3PjxxYU6=
MDA453 cell	MkX4SpVv[3Srb36gZZN{[Xl?			MVnEbZNxdGGlZX3lcpQhd2ZiW{PIYWRJXCCocn;tJIh2dWGwIFHSJIlvKE2GQUS1N{Bk\WyuczygT4k:OC5yMEOg{txO	MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF6MUG0NUc,OTdzOEGxOFE9N2F-
mouse C2C12 cell	M1vncWZ2dmO2aX;uJIF{e2G7			MYrB[49vcXO2IHHjeIl3cXS7IHH0JJJifCCDUjD0doFve2[nY4Tl[EBqdiCvb4Xz[UBEOkNzMjDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJJRz[W6\|YXP0bZZifGmxbjDhd5NigSxiRVO1NF0xNjB{ODFOwG0>	NF;ZXFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{G4NVE1OSd-MUexPFEyPDF:L3G+
monkey COS7 cell	NIHqR5RHfW6ldHnvckBie3OjeR?=			NWS2[llYSmmwZHnu[{Bi\m[rbnn0fUB1dyCqdX3hckBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5ibX;ub4V6KEORU{egZ4VtdHNiYomge4hwdGViY3XscEBjcW6maX7nJIF{e2G7LDDLbV0xNjByMEKg{txO	NITkT2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES0NlkyOid-MUi0OFI6OTJ:L3G+
CHO cell	NYewNWlPTnWwY4Tpc44h[XO\|YYm=			NX76c3VTSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBVT1J3IHX4dJJme3OnZDDpckBEUE9iY3XscJMh[nlibIXjbYZmemG\|ZTDhd5NigSxiRVO1NF01NjR7IN88US=>	NILYTZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOEOwO\|I6PCd-MUizNFczQTR:L3G+
COS7 cell	MULGeY5kfGmxbjDhd5NigQ>?			Ml;0RYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDXO\|QySyCvdYThcpQh\XiycnXzd4VlKGmwIFPPV\|ch[2WubIOgZZN{\XO\|ZXSgZZMhdHWlaX\ldoF{\SCjY4Tpeol1gSCjZoTldkAzPCCqcoOgZpkhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjBzMjFOwG0>	MkS3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOUSyO\|koRjJ{MEm0Nlc6RC:jPh?=
COS7 cell	M3fvXGZ2dmO2aX;uJIF{e2G7			M3HyemFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4KgWFg4P0FibYX0ZY51KGW6cILld5Nm\CCrbjDDU3M4KGOnbHzzJIF{e2W\|c3XkJIF{KGy3Y3nm[ZJie2ViYXP0bZZqfHliYX\0[ZIhOjRiaILzJIJ6KHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5yMUWg{txO	NV[5foJuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwPVQzPzlpPkKyNFk1Ojd7PD;hQi=>
COS7 cell	NVTTO2xxTnWwY4Tpc44h[XO\|YYm=			MoL5RYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hS0:VNzDj[YxteyCjc4Pld5Nm\CCjczDseYNq\mW{YYPlJIFkfGm4aYT5JIFnfGW{IEK0JIhzeyCkeTDy[ZBwenSncjDn[Y5mKGG\|c3H5MEBGSzVyPUCuNFA3OiEQvF2=	NXK4NopERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwPVQzPzlpPkKyNFk1Ojd7PD;hQi=>
LNCaP-hr cell	M{jWUWZ2dmO2aX;uJIF{e2G7		NWD3ZVVWOyCmYYnz	MX7B[49vcXO2IHHjeIl3cXS7IHH0JGFv\HKxZ3XuJJJm[2WydH;yJHQ5PzeDIH31eIFvfCCrbjDoeY1idiCOTlPhVE1peiClZXzsd{Bie3Onc4Pl[EBieyCycn;zeIF1\SC\|cHXjbYZq[yCjboTp[4VvKHOnY4LleIlwdiCvZXHzeZJm\CCjZoTldkA{KGSjeYOgZpkh\W68eX3lMYludXWwb3Hzd4F6NCCHQ{WwQVAvODF3IN88US=>	NHTZRYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G5PVQ4Pyd-MkOxPVk1Pzd:L3G+
LNCaP-hr cell	NIT0eINHfW6ldHnvckBie3OjeR?=		NYq1TlNnOyCmYYnz	MYPB[49vcXO2IHHjeIl3cXS7IHH0JJdqdGRidInw[UBCdmS{b3flckBz\WOncITvdkBqdiCqdX3hckBNVkOjUD3odkBk\WyuczDhd5Nme3OnZDDhd{Bxem:\|dHH0[UB{eGWlaX\pZ{BidnSrZ3XuJJNm[3KndHnvckBu\WG\|dYLl[EBi\nSncjCzJIRigXNiYomg[Y57gW2nLXntcZVvd2G\|c3H5MEBGSzVyPUCuNFA3OiEQvF2=	M1XENlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|MUm5OFc4Lz5{M{G5PVQ4PzxxYU6=
HEK293 cell	NEfJfmJHfW6ldHnvckBie3OjeR?=			MnvDRYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hUEWNMkmzJINmdGy\|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjF6IH7N	M3X2PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{C1Olg5Lz5{NUOwOVY5QDxxYU6=
COS	NVL4XZZSTnWwY4Tpc44h[XO\|YYm=			MYPCbY5lcW6pIHHm[olvcXS7IHHnZYlve3RiQX7kdo9o\W5icnXj[ZB1d3JiZYjwdoV{e2WmIFPPV{Bk\WyuczygT4khRSByLkCwNkDPxE1w	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek86QDdzNUO0K\|46QDdzNUO0QE9iRg>?
COS-1	NV:3OXZ3TnWwY4Tpc44h[XO\|YYm=			MlmxRolv\GmwZzDh[oZqdmm2eTDmc5IhcHWvYX6gRY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW\|c3XkJIlvKEORUz2xJINmdGy\|LDDLbUA:KDBwMECzJO69VS5?	NG\MUmg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi97OUK1O\|I2Lz57OUK1O\|I2RC:jPh?=
CV-1	NEGxTVBHfW6ldHnvckBie3OjeR?=			MYrB[49vcXO2IHHjeIl3cXS7IHHnZYlve3RiSIXtZY4hSW6mcn;n[Y4hemWlZYD0c5Ih\XiycnXzd4VlKGmwIFPWMVEh[2WubIOsJGVEPTBiPTCwMlAxPSEQvF2u	M3PHfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493Nzl7MkW3NlUoRjl7MkW3NlU9N2F-
COS	MoezSpVv[3Srb36gZZN{[Xl?			M4\FNWlvKH[rdILvJIJqdmSrbnegZYZncW6rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4KgeJJidnOoZXP0[YQhcW62bzDDU3Mh[2WubIOuMEBKSzVyIE2gNE4xODRizszNMi=>	NEfydXY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEKzNFYzQCd-MUCyN\|A3Ojh:L3G+
CV-1	NXO0cVR{TnWwY4Tpc44h[XO\|YYm=			NVjTVY5PUW5idnn0do8h[WexbnnzeIlkKGGldHn2bZR6KGGpYXnud5QhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4KgeZNqdmdiY3;0doFve2[nY4Tpc44h[XO\|YYmgbY4hS1ZvMTDj[Yxtey5uIFXDOVAhRSByLkCwOkDPxE1w	M2X5dFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzFyMkOwOlI5Lz5zMEKzNFYzQDxxYU6=
CV-1	M4PTfGZ2dmO2aX;uJIF{e2G7			NF\Nc4tC\2:waYP0JIFkfGm4aYT5JJRwKHSqZTDoeY1idiCjbnTyc4dmdiC{ZXPldJRweiBqaFHSLUBqdiCFVj2xJINmdGy\|LDDFR\|UxKD1iMD6wNFYh\|ryPLh?=	NIjVWZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zMEO0NFYzPCd-MUCzOFA3OjR:L3G+
CV1	NHvGNG9HfW6ldHnvckBie3OjeR?=			NFzXW3dC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJIFv\HKxZ3XuJJJm[2WydH;yJIlvKEOYMTDj[YxteyCvZXHzeZJm\CCjczDzeIlufWyjdHnvckBw\iCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[WO2aY\peJkh[nliY3;0doFve2[nY4Tpc44h[XO\|YYmsJGVEPTBiPTCwMlAxPTFizszNMi=>	NXPjPYJKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUewN\|QyOTdpPkG3NFM1OTF5PD;hQi=>
CV1	MkjDSpVv[3Srb36gZZN{[Xl?			MlO1Rolv\GmwZzDh[oZqdmm2eTD0c{BpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hS1ZzIHPlcIx{NCCNaTC9JFAvODByMjFOwG0v	Mkm1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{NUe4N\|goRjF5MkW3PFM5RC:jPh?=
CV1	MUPGeY5kfGmxbjDhd5NigQ>?			NF\VWGFC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJIFv\HKxZ3XuJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCFVkGgZ4VtdHNuIFXDOVAhRSByLkCwOVEh\|ryPLh?=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ3N{izPEc,OTd{NUe4N\|g9N2F-
MDA-MB-453	MmHhSpVv[3Srb36gZZN{[Xl?			M3;p[mRqe3CuYXPlcYVvfCCxZjDbN2heTEiWIH\yc40hcHWvYX6gRXIh\XiycnXzd4VlKGmwIF3ERU1OSi12NUOgZ4VtdHNuIFvpJF0hOC5yMECzJO69VS5?	NUj0NVJWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N\|kyOTJpPkG3OFM6OTF{PD;hQi=>
CV1	NWHlNZhpTnWwY4Tpc44h[XO\|YYm=			M3TwRmFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gZY5lem:pZX6gdoVk\XC2b4Kg[ZhxemW\|c3XkJIlvKEOYMTDj[YxteyCkeTD0doFve2O{aYD0bY9v[WxiYXP0bZZifGmxbjDhd5NigSxiRVO1NEA:KDBwMEC1O{DPxE1w	NV\NeXRURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe0N\|kyOTJpPkG3OFM6OTF{PD;hQi=>
CV1	M4S5ZWZ2dmO2aX;uJIF{e2G7			MnvaRYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hS1ZzIHPlcIx{KGK7IITyZY5{[3KrcITpc45idCCjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwJF0hOC5yMEW3JO69VS5?	NV;QU2FwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NFM6OzhpPkG3O\|A{QTN6PD;hQi=>
MDA-MB-453	Mme5SpVv[3Srb36gZZN{[Xl?			NVLhR3ZyTGm\|cHzhZ4Vu\W62IH;mJHs{UF2GSGSg[pJwdSCqdX3hckBCdmS{b3flckBz\WOncITvdkBqdiCqdX3hckBOTEFvTVKtOFU{KGOnbHzzMEBMcSB;IECuNFAxQSEQvF2u	NUDtXoRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0NFA1QTlpPkG4OFAxPDl7PD;hQi=>
CV1	M2nie2Z2dmO2aX;uJIF{e2G7			NW\a[nlqSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBidmS{b3flckBz\WOncITvdkBqdiCFVkGgZ4VtdHNiYomgeJJidnOlcnnweIlwdmGuIHHjeIl3[XSrb36gZZN{[XluIFXDOVAhRSByLkCwOVch\|ryPLh?=	M3vubFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6NECwOFk6Lz5zOESwNFQ6QTxxYU6=
Saos2	MU\GeY5kfGmxbjDhd5NigQ>?			MYrBZ5Rqfmm2eTDheEBidmS{b3flckBz\WOncITvdkBqdiCqdX3hckBU[W:\|MjDj[YxteyCjc4Pld5Nm\CCjczDJUFYhemWycnXzd4lwdixiSVO1NEA:KDBwMECwNFUh\|ryPLh?=	NUC1O2FCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi0OFI6OTJpPkG4OFQzQTF{PD;hQi=>
CV1	MnnCSpVv[3Srb36gZZN{[Xl?			MXjB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IHHmdolk[W5iZ4Ll[Y4hdW:wa3X5JGNXOSClZXzsd{BjgSClb4TyZY5{\mWldHnvckBie3OjeTygSWM2OCB;IECuNFA2OSEQvF2u	MmrkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh2NEK5NVIoRjF6NESyPVEzRC:jPh?=
MDA-kb2	M2njcWZ2dmO2aX;uJIF{e2G7			MXjB[49vcXO2IHHjeIl3cXS7IHH0JIFv\HKxZ3XuJJJm[2WydH;yJIlvKGi3bXHuJG1FSS2tYkKgZ4VtdHNiYYPz[ZN{\WRiYYOgd5RqdXWuYYTpc44hd2ZibIXjbYZmemG\|ZTDhZ5Rqfmm2eTDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDNVUxKD1iMD6wNFA2KM7:TT6=	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTV7MkK0OUc,OTl3OUKyOFU9N2F-
MDA-kb2	NUDK[oNKTnWwY4Tpc44h[XO\|YYm=			NV;aOGg3SWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBqdiCqdX3hckBOTEFva3KyJINmdGy\|IHHzd4V{e2WmIHHzJJN1cW23bHH0bY9vKG:oIHz1Z4ln\XKjc3WgZYN1cX[rdImgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR\|E2OCB;IECuNFAxPSEQvF2u	NGfwS4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUW5NlI1PSd-MUm1PVIzPDV:L3G+
MDA-MB-453	MWXGeY5kfGmxbjDhd5NigQ>?			M3\WUmRqe3CuYXPlcYVvfCCxZjDbN2hedWW2aInseJJq\W6xbH;u[UBnem:vIHHu[JJw\2WwIILlZ4VxfG:{IHnuJIh2dWGwIF3ERU1OSi12NUOgZ4VtdHNuIFnDOVAhRSByLkCwNUDPxE1w	NInw[5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOU[wOlg4OCd-MUm2NFY5PzB:L3G+
MDA-MB-453	MX3GeY5kfGmxbjDhd5NigQ>?			M1rOUGFod26rc4SgZYN1cX[rdImgZZQh[W6mcn;n[Y4hemWlZYD0c5IhcW5iaIXtZY4hVUSDLV3CMVQ2OyClZXzsd{B1emGwc3\lZ5Rm\CC5aYToJG1OXFZvTGXDJIF{e2W\|c3XkJIF{KGmwZIXjeIlwdiCxZjDNUXRXNUyWUj;wdo9ud3SncjDsbY5s\WRiTGXDJIdmdmViYomgcJVkcW[ncnHz[UB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVAhRSByLkCwNkDPxE1w	NYDEZnJpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm2NFY5PzBpPkG5OlA3QDdyPD;hQi=>
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NIH3T3	NH7DVFdHfW6ldHnvckBie3OjeR?=			NYnHe5M{SWexbnnzeEBi[3Srdnn0fUBifCCjbnTyc4dmdiC{ZXPldJRweiCrbjDtc5V{\SCQSVizWFMh[2WubIOgeJJidnOrZX70cJkhfHKjboPm[YN1\WRid3n0bEBj\XSjLXfhcIFkfG:\|aXThd4UhemWyb4L0[ZIh\2WwZTDhd5Nme3OnZDDhd{Bk\WyudXzhdkB1emGwc3\vdo1ifGmxbjDifUBTNVODVDDhd5NigSxiRVO1NEA:KDBwMECzPVgyKM7:TT6=	NH7ufHc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUi1OlkzOSd-MUm4OVY6OjF:L3G+
COS7	NUjIPFlnTnWwY4Tpc44h[XO\|YYm=			M3LRd2Fod26rc4SgZYN1cX[rdImgZZQh[W6mcn;n[Y4hemWlZYD0c5IhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBi\nKrY3HuJIdz\WWwIH3vcotmgSCFT2O3JINmdGy\|IHPvMZRz[W6\|ZnXjeIVlKHerdHigS4FtPC2GQlSgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR\|UxKD1iMD6wNkDPxE1w	NV74O3RGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUm4OlMxQDNpPkG5PFY{ODh\|PD;hQi=>
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Freestyle293F	M1G3fWZ2dmO2aX;uJIF{e2G7		MnzhN{BpenN?	NH:zU5ZFcXOybHHj[Y1mdnRib3[gX\|E4NWGucHjhMY1mfGi7bD2zTH0udWmkb3zldo9v\SCocn;tJIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IGS4O\|dCKG23dHHueEBmgHC{ZYPz[YQhcW5iSFXLNlk{KGSncnn2[YQhTnKnZWP0fYxmOjl\|RjDj[YxteyCjZoTldkA{KGi{czygTWM2OCB;IECuNFAzPiEQvF2u	MlT4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOUSyO\|koRjJ{MEm0Nlc6RC:jPh?=
HeLa	MYrGeY5kfGmxbjDhd5NigQ>?			Mmm2WJJidnOjY4TpeoF1cW:wIH;mJIh2dWGwIHHu[JJw\2WwIILlZ4VxfG:{IITyZY5{\mWldHXkJIlvKGi3bXHuJGhmVGFiY3XscJMh[nlibIXjbYZmemG\|ZTDy[ZBwenSncjDn[Y5mKGG\|c3H5MEBC[3Srdnn0fUA:KDBwMEC4JO69VS5?	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh7N{[xNUc,OjJ6OUe2NVE9N2F-
HeLa	NXjTNWJsTnWwY4Tpc44h[XO\|YYm=			M{PGW3BienSrYXygZYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hUGWOYTDj[YxteyClbz3lfJBz\XO\|aX7nJGFTTSCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYnHz[YQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDBZ5Rqfmm2eTC9JFAvODB6IN88UU4>	MlLiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7NUe5OFcoRjJ{OUW3PVQ4RC:jPh?=
Freestyle293F	MonISpVv[3Srb36gZZN{[Xl?			M2TPWmlvcGmkaYTpc44hd2Zid3ns[EB1gXCnIFHu[JJw\2WwIILlZ4VxfG:{IDj1cotvd3ewIH;ybYdqdiliZYjwdoV{e2WmIHnuJGZz\WW\|dIns[VI6O0ZiY3XscJMtKEmFNUCgQUAxNjByMkGg{txONg>?	NHnw[3M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{G5PVQ4Pyd-MkOxPVk1Pzd:L3G+
Freestyle293F	MYXGeY5kfGmxbjDhd5NigQ>?			NHftVnNKdmirYnn0bY9vKG:oIFHu[JJw\2WwIILlZ4VxfG:{IGS4O\|dCKG23dHHueEApfW6tbn;3ckBwemmpaX6pJIV5eHKnc4Pl[EBqdiCIcnXld5R6dGV{OUPGJINmdGy\|LDDJR\|UxKD1iMD6wNFI3KM7:TT6=	MlfvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNzOUm0O\|coRjJ\|MUm5OFc4RC:jPh?=
COS7	NVrYc49OTnWwY4Tpc44h[XO\|YYm=		MU[yJIhzew>?	NV\aRVJyTGm\|cHzhZ4Vu\W62IH;mJHs{UF1iXUXhcJBp[S2GSGSg[pJwdSCvb4Xz[UBidmS{b3flckBz\WOncITvdkBmgHC{ZYPz[YQhcW5ibX;ub4V6KEORU{egZ4VtdHNiYX\0[ZIhOiCqcoOgZpkhe2OrboTpcIxifGmxbjDjc5VvfGmwZzDhcoFtgXOrczygTWM2OCB;IECuNFAyKM7:TT6=	MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV{N{ixOkc,OjN3Mke4NVY9N2F-
C2C12	MV;GeY5kfGmxbjDhd5NigQ>?		NX3vTFVSPSCmYYnz	MXHB[49vcXO2IHHjeIl3cXS7IHH0JIFv\HKxZ3XuJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCvb4Xz[UBEOkNzMjDj[YxteyCjc4Pld5Nm\CCjczDvd5Rmd2KuYYP0JIRq\m[ncnXueIlifGmxbjDh[pRmeiB3IHThfZMtKEWFNUCgQUAxNjByMEC1JO69VS5?	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlyMEK5NEc,OjR7MECyPVA9N2F-
C2C12	MmC2SpVv[3Srb36gZZN{[Xl?			MlnvRYdwdmm\|dDDhZ5Rqfmm2eTDheEBpfW2jbjDhcoRzd2enbjDy[YNmeHSxcjDlfJBz\XO\|ZXSgbY4hdW:3c3WgR\|JEOTJiY3XscJMh[nliYX7kdo9o\W5vc4DlZ4lncWNicnXzdI9ve2ViZXzlcYVvfC2mcnn2[Y4hdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR\|UxKD1iMD6wNFAyOyEQvF2u	NFflV3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUGyNVk3PCd-MkWxNlE6PjR:L3G+
COS7	MWnGeY5kfGmxbjDhd5NigQ>?		NEnHOoszPCCqcoO=	M1rHd2Fod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gRXIh\XiycnXzd4VlKGmwIFHmdolk[W5iZ4Ll[Y4hdW:wa3X5JGNQWzdiY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NEA:KDBwMECzJO69VS5?	MmfKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2NUS4OFkoRjJ6NEW0PFQ6RC:jPh?=
Shionogi	MmWxSpVv[3Srb36gZZN{[Xl?	NV;seoVoOTBicF2=		M{T2bmlv\HWldHnvckBw\iCycn;sbYZmemG2aX;uJI9nKG2xdYPlJHNpcW:wb3fpJINmdGy\|IHH0JFExKHCP	NULGOIg1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUe3NVE5PTVpPkG3O\|EyQDV3PD;hQi=>
MCF7	NYLzeoNXTnWwY4Tpc44h[XO\|YYm=	Mn34N\|AhfU1?	MUKyOEBpenN?	NYDVTWkzSW62YXfvcol{fCCjY4Tpeol1gSCjdDDBVkBqdiCqdX3hckBOS0Z5IHPlcIx{KGG\|c3Xzd4VlKGG\|IILl[JVkfGmxbjDpckBCWiCuZY\lcEBifCB\|MDD1UUBi\nSncjCyOEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{KHKnbHH0bZZmKHSxIHPvcpRzd2x?	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjBzNEe1NUc,OjJyMUS3OVE9N2F-

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Cyclin D1 / Cyclin D2 / Cyclin D3 / Cyclin E2 / Cyclin A1 / AR; PubMed: 26372468 PLoS One HPr-1AR cells were treated with 10 nM DHT or vehicle control for 24–48 hours (h), and immunoblot analysis of cell lysates reveals that cyclin D1 and D2 protein expression decreased substantially with DHT treatment compared to vehicle. p-CDK2 / CDK2 / CDK4 / CDK6 / CDKN1A / p-RB / RB ; PubMed: 26372468 PLoS One HPr-1AR cells were treated with 10 nM DHT or vehicle control for 24–48 hours (h). Immunoblot analysis of cell lysates reveals that CDK4 and CDK6 protein expression decreased and CDKN1A expression increased with DHT treatment compared to vehicle. CDK2 phosphorylation at threonine 160 (T160) decreased nearly 50% with androgen treatment at 24 and 48 hours, albeit not significantly, and total CDK2 protein expression remained unchanged. Relative to total RB expression, the levels of various phosphorylated forms of RB (S780 and S807/811) decreased over time with androgen treatment. p27 / p-p27 ; PubMed: 22139837 J Biol Chem CWR22Rv1 or CWR22R3 cells were stimulated with 10 nm DHT for 6 h, with the addition of MG132 during the last 2 h before harvesting. Proteins were then immunoblotted. AR / PP1 ; PubMed: 26636645 Oncotarget HeLa cells were transfected with Flag-PP1α and HA-AR and then incubated for overnight in androgen-depleted medium without or with androgen (10 nM of DHT) as indicated for blotting.	26372468 22139837 26636645
Immunofluorescence	FOXO1 / p27 ; PubMed: 22139837 J Biol Chem CWR22R3 cells cultured in medium with CDS serum were treated without/with DHT (10 nm) for 4 h. The cells were immunostained for FOXO1 and p27 and examined with a confocal microscope. AKT(S473) / PKCα(S657) ; PubMed: 22139837 J Biol Chem CWR22R3 cells cultured in medium with CDS serum were treated without/with 10 nm DHT (−/+ DHT) for 4 h. The cells were immunostained for AKT or PKCα phosphorylation and examined with a confocal microscope. Bars: 20 μm	22139837

体内研究

DHT可减轻SOD1-G93A小鼠的肌萎缩症状并增加其体重。DHT的处理增加了肌肉中胰岛素样生长因子1的表达，通过逆向轴浆运输发挥其肌肉营养性和神经营养性效果。其处理还减缓了神经肌肉接头处的去神经支配作用、以及减少轴突和运动神经元的丢失。DHT处理的SOD1-G93A小鼠改善了运动行为，生命期限也有所延长^[2]。

细胞实验： ^[1]	- 合并 Cell lines: 膀胱癌细胞 Concentrations: 1 nM Incubation Time: 24 h Method: 对铺于24孔板的、达到50%-60%融合率的细胞进行MMTV-luc报告质粒和PRL-TK-luc质粒共转染实验。转染完6小时后，将培养基替换为含活性炭处理胎牛血清的培养基，加入或不加入配体（DHT、HF或同时加入），处理24小时。收集细胞、溶解、进行荧光素酶活性检测。 (Only for Reference)
动物实验： ^[2]	- 合并 Animal Models: SOD1-G93A mutant mice with the congenic C57BL/6J background Dosages: 5 mg Administration: silastic implant (Only for Reference)

参考文献

溶解度 (25°C)

体外	DMSO	58 mg/mL (199.69 mM)
	Ethanol	58 mg/mL (199.69 mM)
	Water	Insoluble

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download Dihydrotestosterone (DHT) SDF

分子量	290.44
化学式	C₁₉H₃₀O₂
CAS号	521-18-6
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	androstanolone, stanolone, 5α-DHT

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04032067	Not yet recruiting	Drug: GV1001 placebo\|Drug: Proscar placebo	Benign Prostatic Hyperplasia (BPH)	GemVax & Kael	August 28 2019	Phase 3

技术支持

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研究领域

产品类型

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Dihydrotestosterone (DHT)

客户使用Selleck生产的Dihydrotestosterone (DHT)发表文献5篇：

产品安全说明书

Androgen Receptor抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download Dihydrotestosterone (DHT) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2021-01-06)

技术支持

Androgen Receptor Signaling Pathway Map

相关Androgen Receptor产品