RNR

所有产品(4) RNR抑制剂(4)

目录号	产品描述	文献引用	实验数据
S1218	Clofarabine Clofarabine (Clolar)抑制 ribonucleotide reductase (RNR) (IC50 = 65 nM)和 DNA polymerase 的酶活性。Clofarabine 可诱导自噬和凋亡。	Hum Cell, 2021, 10.1007/s13577-021-00579-z Cancer Cell Int, 2020, 19;20:58 Hum Cell, 2020, 10.1007/s13577-020-00425-8	Immunoblot analysis of cell lysates of NCI-H929 cells treated with CLO (5 μM, 3-48 h) GAPDH served as the loading control for each membrane, and data are representative of at least two independent experiments
S7470	Triapine Triapine (3-AP) 是一种强效的ribonucleotide reductase (RNR)抑制剂，通过抑制DNA的合成而具有广谱抗肿瘤活性。	Cell, 2021, 184(2):334-351.e20 Sci Rep, 2021, 11(1):13474 Anticancer Res, 2021, 41(6):2795-2804	(a) Quantification of p-RPA/ Rad51, 53BP1 and γH2AX in GBM01 cells treated with DMSO or triapine. (b) Quantification of p-RPA/Rad51, 53BP1 and γH2AX in GBM02 cells treated with DMSO or triapine.
S0283	COH-29 COH29 (RNR Inhibitor COH29) 是一种有效的 ribonucleotide reductase (RNR) 的抑制剂，具有抗癌活性。COH29 (RNR Inhibitor COH29) 在体外抑制重组 RNR small subunit (RRM1/RRM2) 的活性，对应的IC50值为16 μM。	Adv Sci (Weinh), 2021, e2100881
S3641	Osalmid Osalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.

目录号	产品描述	文献引用	实验数据
S1218	Clofarabine Clofarabine (Clolar)抑制 ribonucleotide reductase (RNR) (IC50 = 65 nM)和 DNA polymerase 的酶活性。Clofarabine 可诱导自噬和凋亡。	Hum Cell,2021, 10.1007/s13577-021-00579-z Cancer Cell Int,2020, 19;20:58 Hum Cell,2020, 10.1007/s13577-020-00425-8	Immunoblot analysis of cell lysates of NCI-H929 cells treated with CLO (5 μM, 3-48 h) GAPDH served as the loading control for each membrane, and data are representative of at least two independent experiments
S7470	Triapine Triapine (3-AP) 是一种强效的ribonucleotide reductase (RNR)抑制剂，通过抑制DNA的合成而具有广谱抗肿瘤活性。	Cell,2021, 184(2):334-351.e20 Sci Rep,2021, 11(1):13474 Anticancer Res,2021, 41(6):2795-2804	(a) Quantification of p-RPA/ Rad51, 53BP1 and γH2AX in GBM01 cells treated with DMSO or triapine. (b) Quantification of p-RPA/Rad51, 53BP1 and γH2AX in GBM02 cells treated with DMSO or triapine.
S0283	COH-29 COH29 (RNR Inhibitor COH29) 是一种有效的 ribonucleotide reductase (RNR) 的抑制剂，具有抗癌活性。COH29 (RNR Inhibitor COH29) 在体外抑制重组 RNR small subunit (RRM1/RRM2) 的活性，对应的IC50值为16 μM。	Adv Sci (Weinh),2021, e2100881
S3641	Osalmid Osalmid suppresses ribonucleotide reductase (RR) activity in a concentration-dependent manner, with a 50% RR activity-inhibitory concentration (IC50) of 8.23 μM.

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