SGK

特异性亚型抑制剂

• SGK1 Selective
• SGK2
• SGK3 Selective

SGK产品

目录号	产品描述	文献引用	实验数据
S7209	GSK650394 GSK650394是一种血清和糖皮质激素调节的激酶-1抑制剂,对SGK1和SGK2的 IC50分别为62 nM和103 nM。	SLAS Discov, 2021, 24725552211002465 Biomedicines, 2021, 9(1)E33 Sci Adv, 2020, 6(50)eabc8096	BV-2 cells were incubated in the absence or presence of gsk650394 (1 μM) for 30 min, followed by LPS (500 ng/ml) administration for 30 min, and then fixed. NF-κB p65 protein was visualized by indirect immunofluorescence staining using an antibody for NF-κB p65. For nuclear staining, the cells were stained with DAPI. Bar = 20 μm.
S8824	EMD638683 EMD638683 是一种 serum- and glucocorticoid-inducible kinase 1 (SGK1) 的高度选择性抑制剂，其IC50值为3 μM。EMD638683 具有降压药效和抗肿瘤活性。
S9672	PROTAC SGK3 degrader-1 PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 是一种包含308-R SGK抑制剂与VH032 VHL结合配体的PROTAC偶联物，靶向 SGK3 (Serum/Glucocorticoid Regulated Kinase Family Member 3) 的降解。

目录号	产品描述	文献引用	实验数据
S7209	GSK650394 GSK650394是一种血清和糖皮质激素调节的激酶-1抑制剂,对SGK1和SGK2的 IC50分别为62 nM和103 nM。	SLAS Discov,2021, 24725552211002465 Biomedicines,2021, 9(1)E33 Sci Adv,2020, 6(50)eabc8096	BV-2 cells were incubated in the absence or presence of gsk650394 (1 μM) for 30 min, followed by LPS (500 ng/ml) administration for 30 min, and then fixed. NF-κB p65 protein was visualized by indirect immunofluorescence staining using an antibody for NF-κB p65. For nuclear staining, the cells were stained with DAPI. Bar = 20 μm.
S8824	EMD638683 EMD638683 是一种 serum- and glucocorticoid-inducible kinase 1 (SGK1) 的高度选择性抑制剂，其IC50值为3 μM。EMD638683 具有降压药效和抗肿瘤活性。
S9672	PROTAC SGK3 degrader-1 PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 是一种包含308-R SGK抑制剂与VH032 VHL结合配体的PROTAC偶联物，靶向 SGK3 (Serum/Glucocorticoid Regulated Kinase Family Member 3) 的降解。