SGK
抑制剂选择性比较
SGK产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S7209 |
GSK650394GSK650394是一种血清和糖皮质激素调节的激酶-1抑制剂,对SGK1和SGK2的 IC50分别为62 nM和103 nM。 |
![]() ![]() BV-2 cells were incubated in the absence or presence of gsk650394 (1 μM) for 30 min, followed by LPS (500 ng/ml) administration for 30 min, and then fixed. NF-κB p65 protein was visualized by indirect immunofluorescence staining using an antibody for NF-κB p65. For nuclear staining, the cells were stained with DAPI. Bar = 20 μm.
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S8824New |
EMD638683EMD638683 是一种 serum- and glucocorticoid-inducible kinase 1 (SGK1) 的高度选择性抑制剂,其IC50值为3 μM。EMD638683 具有降压药效和抗肿瘤活性。 |
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S9672New |
PROTAC SGK3 degrader-1PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 是一种包含308-R SGK抑制剂与VH032 VHL结合配体的PROTAC偶联物,靶向 SGK3 (Serum/Glucocorticoid Regulated Kinase Family Member 3) 的降解。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S7209 |
GSK650394GSK650394是一种血清和糖皮质激素调节的激酶-1抑制剂,对SGK1和SGK2的 IC50分别为62 nM和103 nM。 |
![]() ![]() BV-2 cells were incubated in the absence or presence of gsk650394 (1 μM) for 30 min, followed by LPS (500 ng/ml) administration for 30 min, and then fixed. NF-κB p65 protein was visualized by indirect immunofluorescence staining using an antibody for NF-κB p65. For nuclear staining, the cells were stained with DAPI. Bar = 20 μm.
|
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S8824New |
EMD638683EMD638683 是一种 serum- and glucocorticoid-inducible kinase 1 (SGK1) 的高度选择性抑制剂,其IC50值为3 μM。EMD638683 具有降压药效和抗肿瘤活性。 |
||
S9672New |
PROTAC SGK3 degrader-1PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 是一种包含308-R SGK抑制剂与VH032 VHL结合配体的PROTAC偶联物,靶向 SGK3 (Serum/Glucocorticoid Regulated Kinase Family Member 3) 的降解。 |