Substance P

  • 抑制剂选择性比较
  • 溶解性比较
目录号 产品目录 溶解度(25°C)
DMSO 酒精
S1189 Aprepitant <1 mg/mL 107 mg/mL 15 mg/mL
S4654 Netupitant <1 mg/mL 2 mg/mL 100 mg/mL
产品目录 产品描述 文献引用 实验数据
S1189

Aprepitant

Aprepitant是一种有效的选择性neurokinin-1 receptor拮抗剂,IC50为0.1 nM。

S5476New

Rolapitant

Rolapitant is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.

S4654

Netupitant

Netupitant是一种选择性的神经激肽1(NK1)受体拮抗剂,具有潜在的止吐剂活性。