• CDK1
  • CDK2
  • CDK3
  • CDK4
  • CDK5
  • CDK6
  • CDK7
  • CDK9
  • CLK
  • Cdc
  • CDK8
  • CDK12
  • CDK13
  • CDK19
  • CDK11
  • CDK/cyclin complexes

CDK13 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S8894 SR-4835 SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13 with IC50 of 99 nM and Kd of 98 nM for CDK12 and IC50 of 4.9 nM for CDK13. SR-4835 disables triple-negative breast cancer (TNBC) cells. SR-4835 promotes synergy with DNA-damaging chemotherapy and PARP inhibitors. Selective CDK13, IC50: 4.9 nM
S6595 THZ531 THZ531 is a selective covalent inhibitor of CDK12 and CDK13 with IC50 values of 158 and 69 nM, respectively. Pan CDK13, IC50: 69 nM
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