HSF1 选择性抑制剂

目录号 产品名 产品描述 Selective / Pan IC50 / Ki
S7428 Rocaglamide

Rocaglamide is a potent inhibitor of NF-κB activation and heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits thetranslation initiation factor eIF4A with anticancer properties in leukemia. Rocaglamide is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases.

Selective HSF1, IC50: 50 nM

DTHIB (Direct Targeted HSF1 InhiBitor) is a direct and selective inhibitor of heat shock factor 1 (HSF1) with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB exhibits potently anticancer activities.

Selective HSF1, Kd: 160 nM
S8402 KRIBB11

KRIBB11抑制热激诱导的荧光素酶活性,IC50为1.2 μM。它是转录因子热休克因子1(HSF1)的抑制剂。

Selective HSF1, IC50: 1.2 μM
S3604 Triptolide (PG490)

Triptolide (PG490) 是一种三环氧二萜类化合物,是从中草药雷公藤中提取的免疫抑制剂。它是一种NF-κB抑制剂,抑制NF-κB转录活性,破坏p65/CBP的相互作用,减少p65蛋白。