Wee1

所有产品(2) Wee1抑制剂(2)

目录号	产品描述	文献引用	实验数据
S1525	Adavosertib (MK-1775) Adavosertib (MK-1775, AZD1775)是一种有效的，高选择性Wee1抑制剂，无细胞试验中IC50为5.2 nM；阻碍G2期DNA损伤检验点。Phase 2。	Cancer Cell, 2020, 15 pii: S1535-6108(20)30164-1 Sci Adv, 2020, 6(24):eaaz7808 Clin Cancer Res, 2020, 27 pii: clincanres	Diagnostic AML blasts from patients either at first diagnosis or at relapse are equally sensitive to MK-1775. Freshly isolated cells from patient AML#10 were purified by standard Ficoll-Hypaque density centrifugation. AML#10, HL-60, and HL-60/Ara-C cells were treated with MK-1775 for 48 h. Whole cell lysates were subjected to Western blotting and probed with anti-p-CDK1, -CDK1, -p-CDK2, -CDK2, -γH2AX, or -β-actin antibody.
S8148	PD0166285 PD0166285 是一种有效的 Wee1 和 Chk1 抑制剂，对Wee1和Myt1的IC50值分别为24 nM和72 nM。PD0166285 也是一种新型的G2检查点的抑制剂。PD0166285 可诱导凋亡。	Cancer Sci, 2020, 112(1):133-143 Nature, 2019, 10.1038/s41586-019-1607-3 Nature, 2019, 574(7777):268-272

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产品描述

文献引用

实验数据

S1525

Adavosertib (MK-1775, AZD1775)是一种有效的，高选择性Wee1抑制剂，无细胞试验中IC50为5.2 nM；阻碍G2期DNA损伤检验点。Phase 2。

S8148

PD0166285 是一种有效的 Wee1 和 Chk1 抑制剂，对Wee1和Myt1的IC50值分别为24 nM和72 nM。PD0166285 也是一种新型的G2检查点的抑制剂。PD0166285 可诱导凋亡。

目录号	产品描述	文献引用	实验数据
S1525	Adavosertib (MK-1775) Adavosertib (MK-1775, AZD1775)是一种有效的，高选择性Wee1抑制剂，无细胞试验中IC50为5.2 nM；阻碍G2期DNA损伤检验点。Phase 2。	Cancer Cell,2020, 15 pii: S1535-6108(20)30164-1 Sci Adv,2020, 6(24):eaaz7808 Clin Cancer Res,2020, 27 pii: clincanres	Diagnostic AML blasts from patients either at first diagnosis or at relapse are equally sensitive to MK-1775. Freshly isolated cells from patient AML#10 were purified by standard Ficoll-Hypaque density centrifugation. AML#10, HL-60, and HL-60/Ara-C cells were treated with MK-1775 for 48 h. Whole cell lysates were subjected to Western blotting and probed with anti-p-CDK1, -CDK1, -p-CDK2, -CDK2, -γH2AX, or -β-actin antibody.
S8148	PD0166285 PD0166285 是一种有效的 Wee1 和 Chk1 抑制剂，对Wee1和Myt1的IC50值分别为24 nM和72 nM。PD0166285 也是一种新型的G2检查点的抑制剂。PD0166285 可诱导凋亡。	Cancer Sci,2020, 112(1):133-143 Nature,2019, 10.1038/s41586-019-1607-3 Nature,2019, 574(7777):268-272

目录号

产品描述

文献引用

实验数据

S1525