Obatoclax Mesylate (GX15-070)
中文名称：奥巴克拉甲磺酸盐
Obatoclax Mesylate (GX15-070)是一种Bcl-2拮抗剂，无细胞试验中Ki为0.22 μM，可以协助抑制MCL-1介导的抗细胞凋亡作用。
Obatoclax Mesylate (GX15-070) Chemical Structure
CAS: 803712-79-0
客户使用Selleck的Obatoclax Mesylate (GX15-070)发表文献108篇
产品质控
批次：
纯度：
99.85%
99.85
Obatoclax Mesylate (GX15-070)相关产品
| 相关靶点 | Bcl-2 Bcl-B Bcl-w Bcl-xL Mcl-1 Bax Bfl-1 Bad Bcl-xL | 点击展开 |
|---|---|---|
| 相关化合物库 | 自噬化合物库 凋亡分子化合物库 铁死亡化合物库 细胞焦亡化合物库 线粒体靶向化合物库 | 点击展开 |
相关信号通路图
Bcl-2抑制剂选择性比较
细胞实验数据示例
| 细胞系 | 实验类型 | 给药浓度 | 孵育时间 | 活性描述 | 文献信息 |
|---|---|---|---|---|---|
| SW1783 | Growth Inhibition Assay | IC50=0.19305 μM | SANGER | ||
| AM-38 | Growth Inhibition Assay | IC50=0.19225 μM | SANGER | ||
| NCI-H441 | Growth Inhibition Assay | IC50=0.19148 μM | SANGER | ||
| MHH-ES-1 | Growth Inhibition Assay | IC50=0.18629 μM | SANGER | ||
| LCLC-103H | Growth Inhibition Assay | IC50=0.18527 μM | SANGER | ||
| Hs-578-T | Growth Inhibition Assay | IC50=0.18292 μM | SANGER | ||
| NCI-H522 | Growth Inhibition Assay | IC50=0.18094 μM | SANGER | ||
| MV-4-11 | Growth Inhibition Assay | IC50=0.17977 μM | SANGER | ||
| 8305C | Growth Inhibition Assay | IC50=0.17971 μM | SANGER | ||
| TYK-nu | Growth Inhibition Assay | IC50=0.17949 μM | SANGER | ||
| TK10 | Growth Inhibition Assay | IC50=0.17702 μM | SANGER | ||
| MKN28 | Growth Inhibition Assay | IC50=0.17653 μM | SANGER | ||
| NCI-H292 | Growth Inhibition Assay | IC50=0.17601 μM | SANGER | ||
| BB65-RCC | Growth Inhibition Assay | IC50=0.17545 μM | SANGER | ||
| BT-474 | Growth Inhibition Assay | IC50=0.17489 μM | SANGER | ||
| DJM-1 | Growth Inhibition Assay | IC50=0.17451 μM | SANGER | ||
| HCC1143 | Growth Inhibition Assay | IC50=0.17396 μM | SANGER | ||
| EB-3 | Growth Inhibition Assay | IC50=0.1731 μM | SANGER | ||
| D-542MG | Growth Inhibition Assay | IC50=0.16986 μM | SANGER | ||
| HLE | Growth Inhibition Assay | IC50=0.16877 μM | SANGER | ||
| ATN-1 | Growth Inhibition Assay | IC50=0.16656 μM | SANGER | ||
| KARPAS-422 | Growth Inhibition Assay | IC50=0.16574 μM | SANGER | ||
| GB-1 | Growth Inhibition Assay | IC50=0.16424 μM | SANGER | ||
| GT3TKB | Growth Inhibition Assay | IC50=0.16283 μM | SANGER | ||
| YKG-1 | Growth Inhibition Assay | IC50=0.16273 μM | SANGER | ||
| DU-4475 | Growth Inhibition Assay | IC50=0.16162 μM | SANGER | ||
| SW872 | Growth Inhibition Assay | IC50=0.16042 μM | SANGER | ||
| SK-MEL-2 | Growth Inhibition Assay | IC50=0.15668 μM | SANGER | ||
| AN3-CA | Growth Inhibition Assay | IC50=0.15639 μM | SANGER | ||
| 639-V | Growth Inhibition Assay | IC50=0.15596 μM | SANGER | ||
| HEL | Growth Inhibition Assay | IC50=0.15447 μM | SANGER | ||
| NCI-H1355 | Growth Inhibition Assay | IC50=0.15293 μM | SANGER | ||
| SJSA-1 | Growth Inhibition Assay | IC50=0.14707 μM | SANGER | ||
| TE-1 | Growth Inhibition Assay | IC50=0.14407 μM | SANGER | ||
| ES6 | Growth Inhibition Assay | IC50=0.1436 μM | SANGER | ||
| NCI-H747 | Growth Inhibition Assay | IC50=0.143 μM | SANGER | ||
| LS-411N | Growth Inhibition Assay | IC50=0.14295 μM | SANGER | ||
| RD | Growth Inhibition Assay | IC50=0.13997 μM | SANGER | ||
| MFE-296 | Growth Inhibition Assay | IC50=0.13864 μM | SANGER | ||
| SK-UT-1 | Growth Inhibition Assay | IC50=0.13628 μM | SANGER | ||
| SK-LU-1 | Growth Inhibition Assay | IC50=0.13449 μM | SANGER | ||
| RPMI-8866 | Growth Inhibition Assay | IC50=0.13261 μM | SANGER | ||
| ACHN | Growth Inhibition Assay | IC50=0.13247 μM | SANGER | ||
| QIMR-WIL | Growth Inhibition Assay | IC50=0.13223 μM | SANGER | ||
| COLO-792 | Growth Inhibition Assay | IC50=0.13165 μM | SANGER | ||
| NCI-H2087 | Growth Inhibition Assay | IC50=0.13027 μM | SANGER | ||
| EW-18 | Growth Inhibition Assay | IC50=0.13026 μM | SANGER | ||
| Ramos-2G6-4C10 | Growth Inhibition Assay | IC50=0.12916 μM | SANGER | ||
| SNU-423 | Growth Inhibition Assay | IC50=0.12914 μM | SANGER | ||
| SK-MES-1 | Growth Inhibition Assay | IC50=0.12913 μM | SANGER | ||
| NCI-H520 | Growth Inhibition Assay | IC50=0.12867 μM | SANGER | ||
| BE-13 | Growth Inhibition Assay | IC50=0.12866 μM | SANGER | ||
| HT-1376 | Growth Inhibition Assay | IC50=0.12668 μM | SANGER | ||
| HCE-T | Growth Inhibition Assay | IC50=0.12531 μM | SANGER | ||
| HCC1806 | Growth Inhibition Assay | IC50=0.12383 μM | SANGER | ||
| EFM-19 | Growth Inhibition Assay | IC50=0.12374 μM | SANGER | ||
| NCI-SNU-1 | Growth Inhibition Assay | IC50=0.12148 μM | SANGER | ||
| NY | Growth Inhibition Assay | IC50=0.11817 μM | SANGER | ||
| J-RT3-T3-5 | Growth Inhibition Assay | IC50=0.1175 μM | SANGER | ||
| NCI-H810 | Growth Inhibition Assay | IC50=0.11664 μM | SANGER | ||
| ES8 | Growth Inhibition Assay | IC50=0.11633 μM | SANGER | ||
| SF539 | Growth Inhibition Assay | IC50=0.11616 μM | SANGER | ||
| PANC-10-05 | Growth Inhibition Assay | IC50=0.11491 μM | SANGER | ||
| EoL-1-cell | Growth Inhibition Assay | IC50=0.11467 μM | SANGER | ||
| MC116 | Growth Inhibition Assay | IC50=0.11337 μM | SANGER | ||
| NCI-H1648 | Growth Inhibition Assay | IC50=0.11286 μM | SANGER | ||
| Ca9-22 | Growth Inhibition Assay | IC50=0.11128 μM | SANGER | ||
| ARH-77 | Growth Inhibition Assay | IC50=0.11 μM | SANGER | ||
| J82 | Growth Inhibition Assay | IC50=0.10884 μM | SANGER | ||
| MZ1-PC | Growth Inhibition Assay | IC50=0.1083 μM | SANGER | ||
| A2058 | Growth Inhibition Assay | IC50=0.10655 μM | SANGER | ||
| NTERA-S-cl-D1 | Growth Inhibition Assay | IC50=0.10448 μM | SANGER | ||
| HTC-C3 | Growth Inhibition Assay | IC50=0.10432 μM | SANGER | ||
| 647-V | Growth Inhibition Assay | IC50=0.10408 μM | SANGER | ||
| HUTU-80 | Growth Inhibition Assay | IC50=0.10365 μM | SANGER | ||
| ES4 | Growth Inhibition Assay | IC50=0.10264 μM | SANGER | ||
| LB771-HNC | Growth Inhibition Assay | IC50=0.10255 μM | SANGER | ||
| NCI-H460 | Growth Inhibition Assay | IC50=0.1009 μM | SANGER | ||
| MN-60 | Growth Inhibition Assay | IC50=0.09897 μM | SANGER | ||
| TE-8 | Growth Inhibition Assay | IC50=0.09885 μM | SANGER | ||
| KYSE-410 | Growth Inhibition Assay | IC50=0.09797 μM | SANGER | ||
| PANC-03-27 | Growth Inhibition Assay | IC50=0.09671 μM | SANGER | ||
| TE-10 | Growth Inhibition Assay | IC50=0.09584 μM | SANGER | ||
| IST-SL2 | Growth Inhibition Assay | IC50=0.09468 μM | SANGER | ||
| U-698-M | Growth Inhibition Assay | IC50=0.09409 μM | SANGER | ||
| NCI-H2122 | Growth Inhibition Assay | IC50=0.09378 μM | SANGER | ||
| HO-1-N-1 | Growth Inhibition Assay | IC50=0.09249 μM | SANGER | ||
| A704 | Growth Inhibition Assay | IC50=0.0915 μM | SANGER | ||
| KMOE-2 | Growth Inhibition Assay | IC50=0.09039 μM | SANGER | ||
| Calu-6 | Growth Inhibition Assay | IC50=0.09029 μM | SANGER | ||
| RPMI-6666 | Growth Inhibition Assay | IC50=0.08967 μM | SANGER | ||
| A4-Fuk | Growth Inhibition Assay | IC50=0.08947 μM | SANGER | ||
| HCT-116 | Growth Inhibition Assay | IC50=0.08802 μM | SANGER | ||
| A431 | Growth Inhibition Assay | IC50=0.08801 μM | SANGER | ||
| CP50-MEL-B | Growth Inhibition Assay | IC50=0.08793 μM | SANGER | ||
| PA-1 | Growth Inhibition Assay | IC50=0.08769 μM | SANGER | ||
| LoVo | Growth Inhibition Assay | IC50=0.0872 μM | SANGER | ||
| LS-123 | Growth Inhibition Assay | IC50=0.08719 μM | SANGER | ||
| A3-KAW | Growth Inhibition Assay | IC50=0.08566 μM | SANGER | ||
| A427 | Growth Inhibition Assay | IC50=0.08512 μM | SANGER | ||
| KURAMOCHI | Growth Inhibition Assay | IC50=0.08509 μM | SANGER | ||
| RS4-11 | Growth Inhibition Assay | IC50=0.08497 μM | SANGER | ||
| 5637 | Growth Inhibition Assay | IC50=0.08367 μM | SANGER | ||
| DEL | Growth Inhibition Assay | IC50=0.08347 μM | SANGER | ||
| HuCCT1 | Growth Inhibition Assay | IC50=0.08333 μM | SANGER | ||
| CESS | Growth Inhibition Assay | IC50=0.08269 μM | SANGER | ||
| HOP-62 | Growth Inhibition Assay | IC50=0.08245 μM | SANGER | ||
| CHP-212 | Growth Inhibition Assay | IC50=0.08095 μM | SANGER | ||
| NCI-H727 | Growth Inhibition Assay | IC50=0.08053 μM | SANGER | ||
| BFTC-905 | Growth Inhibition Assay | IC50=0.07909 μM | SANGER | ||
| NCI-H358 | Growth Inhibition Assay | IC50=0.07879 μM | SANGER | ||
| 8-MG-BA | Growth Inhibition Assay | IC50=0.07801 μM | SANGER | ||
| MMAC-SF | Growth Inhibition Assay | IC50=0.07668 μM | SANGER | ||
| CTB-1 | Growth Inhibition Assay | IC50=0.07588 μM | SANGER | ||
| WSU-NHL | Growth Inhibition Assay | IC50=0.07554 μM | SANGER | ||
| MLMA | Growth Inhibition Assay | IC50=0.07534 μM | SANGER | ||
| CTV-1 | Growth Inhibition Assay | IC50=0.07517 μM | SANGER | ||
| BxPC-3 | Growth Inhibition Assay | IC50=0.07458 μM | SANGER | ||
| P12-ICHIKAWA | Growth Inhibition Assay | IC50=0.07349 μM | SANGER | ||
| YT | Growth Inhibition Assay | IC50=0.07345 μM | SANGER | ||
| ESS-1 | Growth Inhibition Assay | IC50=0.07246 μM | SANGER | ||
| SW626 | Growth Inhibition Assay | IC50=0.07204 μM | SANGER | ||
| Daudi | Growth Inhibition Assay | IC50=0.07081 μM | SANGER | ||
| KYSE-70 | Growth Inhibition Assay | IC50=0.06945 μM | SANGER | ||
| NCI-H226 | Growth Inhibition Assay | IC50=0.06632 μM | SANGER | ||
| SW962 | Growth Inhibition Assay | IC50=0.06569 μM | SANGER | ||
| CA46 | Growth Inhibition Assay | IC50=0.06537 μM | SANGER | ||
| CAL-27 | Growth Inhibition Assay | IC50=0.06464 μM | SANGER | ||
| NB13 | Growth Inhibition Assay | IC50=0.06421 μM | SANGER | ||
| NOS-1 | Growth Inhibition Assay | IC50=0.06411 μM | SANGER | ||
| BL-70 | Growth Inhibition Assay | IC50=0.06302 μM | SANGER | ||
| BL-41 | Growth Inhibition Assay | IC50=0.06219 μM | SANGER | ||
| LOXIMVI | Growth Inhibition Assay | IC50=0.06188 μM | SANGER | ||
| KYSE-180 | Growth Inhibition Assay | IC50=0.06142 μM | SANGER | ||
| COR-L23 | Growth Inhibition Assay | IC50=0.06134 μM | SANGER | ||
| NCI-H1299 | Growth Inhibition Assay | IC50=0.0613 μM | SANGER | ||
| IA-LM | Growth Inhibition Assay | IC50=0.06053 μM | SANGER | ||
| BC-1 | Growth Inhibition Assay | IC50=0.06022 μM | SANGER | ||
| BCPAP | Growth Inhibition Assay | IC50=0.05892 μM | SANGER | ||
| GAMG | Growth Inhibition Assay | IC50=0.058 μM | SANGER | ||
| OCI-AML2 | Growth Inhibition Assay | IC50=0.05777 μM | SANGER | ||
| SF268 | Growth Inhibition Assay | IC50=0.05756 μM | SANGER | ||
| SK-PN-DW | Growth Inhibition Assay | IC50=0.05729 μM | SANGER | ||
| COLO-205 | Growth Inhibition Assay | IC50=0.05716 μM | SANGER | ||
| A388 | Growth Inhibition Assay | IC50=0.05695 μM | SANGER | ||
| ETK-1 | Growth Inhibition Assay | IC50=0.05672 μM | SANGER | ||
| Daoy | Growth Inhibition Assay | IC50=0.05616 μM | SANGER | ||
| LCLC-97TM1 | Growth Inhibition Assay | IC50=0.05594 μM | SANGER | ||
| NEC8 | Growth Inhibition Assay | IC50=0.0559 μM | SANGER | ||
| 697 | Growth Inhibition Assay | IC50=0.05323 μM | SANGER | ||
| COLO-320-HSR | Growth Inhibition Assay | IC50=0.05289 μM | SANGER | ||
| PC-14 | Growth Inhibition Assay | IC50=0.05252 μM | SANGER | ||
| HMV-II | Growth Inhibition Assay | IC50=0.05239 μM | SANGER | ||
| NCI-H2342 | Growth Inhibition Assay | IC50=0.05117 μM | SANGER | ||
| LK-2 | Growth Inhibition Assay | IC50=0.05063 μM | SANGER | ||
| COLO-680N | Growth Inhibition Assay | IC50=0.05047 μM | SANGER | ||
| PF-382 | Growth Inhibition Assay | IC50=0.04939 μM | SANGER | ||
| MRK-nu-1 | Growth Inhibition Assay | IC50=0.04936 μM | SANGER | ||
| SCC-15 | Growth Inhibition Assay | IC50=0.04902 μM | SANGER | ||
| ES1 | Growth Inhibition Assay | IC50=0.04885 μM | SANGER | ||
| CHL-1 | Growth Inhibition Assay | IC50=0.04857 μM | SANGER | ||
| NCI-H1770 | Growth Inhibition Assay | IC50=0.04697 μM | SANGER | ||
| L-363 | Growth Inhibition Assay | IC50=0.04679 μM | SANGER | ||
| REH | Growth Inhibition Assay | IC50=0.04635 μM | SANGER | ||
| SCC-25 | Growth Inhibition Assay | IC50=0.04494 μM | SANGER | ||
| HT-29 | Growth Inhibition Assay | IC50=0.0449 μM | SANGER | ||
| EW-13 | Growth Inhibition Assay | IC50=0.04406 μM | SANGER | ||
| LB373-MEL-D | Growth Inhibition Assay | IC50=0.04232 μM | SANGER | ||
| HuP-T4 | Growth Inhibition Assay | IC50=0.04118 μM | SANGER | ||
| SW1710 | Growth Inhibition Assay | IC50=0.04018 μM | SANGER | ||
| KYSE-150 | Growth Inhibition Assay | IC50=0.04011 μM | SANGER | ||
| CAL-51 | Growth Inhibition Assay | IC50=0.04005 μM | SANGER | ||
| EW-16 | Growth Inhibition Assay | IC50=0.03909 μM | SANGER | ||
| NCI-H64 | Growth Inhibition Assay | IC50=0.03842 μM | SANGER | ||
| SW756 | Growth Inhibition Assay | IC50=0.03821 μM | SANGER | ||
| HEC-1 | Growth Inhibition Assay | IC50=0.0368 μM | SANGER | ||
| HOS | Growth Inhibition Assay | IC50=0.03473 μM | SANGER | ||
| DoTc2-4510 | Growth Inhibition Assay | IC50=0.03393 μM | SANGER | ||
| IMR-5 | Growth Inhibition Assay | IC50=0.03244 μM | SANGER | ||
| OVCAR-8 | Growth Inhibition Assay | IC50=0.03107 μM | SANGER | ||
| G-401 | Growth Inhibition Assay | IC50=0.03093 μM | SANGER | ||
| A101D | Growth Inhibition Assay | IC50=0.03055 μM | SANGER | ||
| NUGC-3 | Growth Inhibition Assay | IC50=0.03048 μM | SANGER | ||
| 8505C | Growth Inhibition Assay | IC50=0.0304 μM | SANGER | ||
| CMK | Growth Inhibition Assay | IC50=0.03023 μM | SANGER | ||
| KYSE-270 | Growth Inhibition Assay | IC50=0.02976 μM | SANGER | ||
| MZ2-MEL | Growth Inhibition Assay | IC50=0.02959 μM | SANGER | ||
| SUP-T1 | Growth Inhibition Assay | IC50=0.02949 μM | SANGER | ||
| S-117 | Growth Inhibition Assay | IC50=0.02906 μM | SANGER | ||
| DMS-273 | Growth Inhibition Assay | IC50=0.02847 μM | SANGER | ||
| CAL-62 | Growth Inhibition Assay | IC50=0.02602 μM | SANGER | ||
| MEL-JUSO | Growth Inhibition Assay | IC50=0.02473 μM | SANGER | ||
| HSC-2 | Growth Inhibition Assay | IC50=0.02466 μM | SANGER | ||
| MC-CAR | Growth Inhibition Assay | IC50=0.02356 μM | SANGER | ||
| MEL-HO | Growth Inhibition Assay | IC50=0.02348 μM | SANGER | ||
| RPMI-2650 | Growth Inhibition Assay | IC50=0.02296 μM | SANGER | ||
| A2780 | Growth Inhibition Assay | IC50=0.02079 μM | SANGER | ||
| ONS-76 | Growth Inhibition Assay | IC50=0.02036 μM | SANGER | ||
| THP-1 | Growth Inhibition Assay | IC50=0.01998 μM | SANGER | ||
| RPMI-8402 | Growth Inhibition Assay | IC50=0.01858 μM | SANGER | ||
| CAL-85-1 | Growth Inhibition Assay | IC50=0.01832 μM | SANGER | ||
| HCC1569 | Growth Inhibition Assay | IC50=0.01797 μM | SANGER | ||
| TGW | Growth Inhibition Assay | IC50=0.01739 μM | SANGER | ||
| RVH-421 | Growth Inhibition Assay | IC50=0.01674 μM | SANGER | ||
| LC-2-ad | Growth Inhibition Assay | IC50=0.01581 μM | SANGER | ||
| NB69 | Growth Inhibition Assay | IC50=0.01565 μM | SANGER | ||
| DOHH-2 | Growth Inhibition Assay | IC50=0.01412 μM | SANGER | ||
| HSC-3 | Growth Inhibition Assay | IC50=0.01355 μM | SANGER | ||
| CAL-12T | Growth Inhibition Assay | IC50=0.01346 μM | SANGER | ||
| SNG-M | Growth Inhibition Assay | IC50=0.01317 μM | SANGER | ||
| SR | Growth Inhibition Assay | IC50=0.01235 μM | SANGER | ||
| SW1417 | Growth Inhibition Assay | IC50=0.01225 μM | SANGER | ||
| ACN | Growth Inhibition Assay | IC50=0.01131 μM | SANGER | ||
| RKO | Growth Inhibition Assay | IC50=0.01044 μM | SANGER | ||
| NKM-1 | Growth Inhibition Assay | IC50=0.00972 μM | SANGER | ||
| IPC-298 | Growth Inhibition Assay | IC50=0.00927 μM | SANGER | ||
| BB30-HNC | Growth Inhibition Assay | IC50=0.00858 μM | SANGER | ||
| GAK | Growth Inhibition Assay | IC50=0.00848 μM | SANGER | ||
| ES7 | Growth Inhibition Assay | IC50=0.00846 μM | SANGER | ||
| ST486 | Growth Inhibition Assay | IC50=0.00825 μM | SANGER | ||
| IST-MEL1 | Growth Inhibition Assay | IC50=0.00818 μM | SANGER | ||
| SIG-M5 | Growth Inhibition Assay | IC50=0.0071 μM | SANGER | ||
| HN | Growth Inhibition Assay | IC50=0.00679 μM | SANGER | ||
| 769-P | Growth Inhibition Assay | IC50=0.00678 μM | SANGER | ||
| EW-1 | Growth Inhibition Assay | IC50=0.00651 μM | SANGER | ||
| IGR-1 | Growth Inhibition Assay | IC50=0.00601 μM | SANGER | ||
| IGROV-1 | Growth Inhibition Assay | IC50=0.006 μM | SANGER | ||
| HGC-27 | Growth Inhibition Assay | IC50=0.00524 μM | SANGER | ||
| SW620 | Growth Inhibition Assay | IC50=0.00511 μM | SANGER | ||
| COLO-679 | Growth Inhibition Assay | IC50=0.00498 μM | SANGER | ||
| PSN1 | Growth Inhibition Assay | IC50=0.00467 μM | SANGER | ||
| KYSE-140 | Growth Inhibition Assay | IC50=0.00435 μM | SANGER | ||
| HT-144 | Growth Inhibition Assay | IC50=0.0043 μM | SANGER | ||
| SH-4 | Growth Inhibition Assay | IC50=0.00417 μM | SANGER | ||
| MZ7-mel | Growth Inhibition Assay | IC50=0.00399 μM | SANGER | ||
| A375 | Growth Inhibition Assay | IC50=0.0035 μM | SANGER | ||
| HCC2998 | Growth Inhibition Assay | IC50=0.00335 μM | SANGER | ||
| HAL-01 | Growth Inhibition Assay | IC50=0.00297 μM | SANGER | ||
| SK-MEL-3 | Growth Inhibition Assay | IC50=0.00264 μM | SANGER | ||
| KYSE-510 | Growth Inhibition Assay | IC50=0.00233 μM | SANGER | ||
| EW-7 | Growth Inhibition Assay | IC50=0.00175 μM | SANGER | ||
| LOUCY | Growth Inhibition Assay | IC50=0.00175 μM | SANGER | ||
| MCF7 | Growth Inhibition Assay | IC50=0.00159 μM | SANGER | ||
| MHH-PREB-1 | Growth Inhibition Assay | IC50=0.0014 μM | SANGER | ||
| KE-37 | Growth Inhibition Assay | IC50=0.00128 μM | SANGER | ||
| G-361 | Growth Inhibition Assay | IC50=0.00124 μM | SANGER | ||
| EB2 | Growth Inhibition Assay | IC50=0.00118 μM | SANGER | ||
| BHT-101 | Growth Inhibition Assay | IC50=0.00106 μM | SANGER | ||
| C-33-A | Growth Inhibition Assay | IC50=0.000848 μM | SANGER | ||
| 786-0 | Growth Inhibition Assay | IC50=0.000776 μM | SANGER | ||
| GR-ST | Growth Inhibition Assay | IC50=0.000648 μM | SANGER | ||
| BHY | Growth Inhibition Assay | IC50=0.000601 μM | SANGER | ||
| KYSE-450 | Growth Inhibition Assay | IC50=0.000469 μM | SANGER | ||
| NALM-6 | Growth Inhibition Assay | IC50=0.000356 μM | SANGER | ||
| SK-MEL-30 | Growth Inhibition Assay | IC50=0.000355 μM | SANGER | ||
| KARPAS-45 | Growth Inhibition Assay | IC50=0.0000317 μM | SANGER | ||
| SK-HEP-1 | Growth Inhibition Assay | IC50=0.19637 μM | SANGER | ||
| OAW-28 | Growth Inhibition Assay | IC50=0.20178 μM | SANGER | ||
| TE-15 | Growth Inhibition Assay | IC50=0.20252 μM | SANGER | ||
| HCE-4 | Growth Inhibition Assay | IC50=0.20284 μM | SANGER | ||
| JiyoyeP-2003 | Growth Inhibition Assay | IC50=0.20336 μM | SANGER | ||
| OVCAR-4 | Growth Inhibition Assay | IC50=0.20628 μM | SANGER | ||
| SNU-449 | Growth Inhibition Assay | IC50=0.20797 μM | SANGER | ||
| SBC-5 | Growth Inhibition Assay | IC50=0.21215 μM | SANGER | ||
| T84 | Growth Inhibition Assay | IC50=0.21248 μM | SANGER | ||
| LP-1 | Growth Inhibition Assay | IC50=0.21302 μM | SANGER | ||
| MG-63 | Growth Inhibition Assay | IC50=0.21382 μM | SANGER | ||
| OAW-42 | Growth Inhibition Assay | IC50=0.21478 μM | SANGER | ||
| L-540 | Growth Inhibition Assay | IC50=0.21598 μM | SANGER | ||
| RH-1 | Growth Inhibition Assay | IC50=0.22242 μM | SANGER | ||
| HCT-15 | Growth Inhibition Assay | IC50=0.22484 μM | SANGER | ||
| OCUB-M | Growth Inhibition Assay | IC50=0.22488 μM | SANGER | ||
| GP5d | Growth Inhibition Assay | IC50=0.22528 μM | SANGER | ||
| NCI-H2030 | Growth Inhibition Assay | IC50=0.22734 μM | SANGER | ||
| ML-2 | Growth Inhibition Assay | IC50=0.22889 μM | SANGER | ||
| CAL-39 | Growth Inhibition Assay | IC50=0.22936 μM | SANGER | ||
| MIA-PaCa-2 | Growth Inhibition Assay | IC50=0.23287 μM | SANGER | ||
| TE-9 | Growth Inhibition Assay | IC50=0.2332 μM | SANGER | ||
| LB2518-MEL | Growth Inhibition Assay | IC50=0.23372 μM | SANGER | ||
| DB | Growth Inhibition Assay | IC50=0.23438 μM | SANGER | ||
| NCI-H596 | Growth Inhibition Assay | IC50=0.23571 μM | SANGER | ||
| SW1990 | Growth Inhibition Assay | IC50=0.23946 μM | SANGER | ||
| P30-OHK | Growth Inhibition Assay | IC50=0.2405 μM | SANGER | ||
| ALL-PO | Growth Inhibition Assay | IC50=0.24169 μM | SANGER | ||
| Saos-2 | Growth Inhibition Assay | IC50=0.24571 μM | SANGER | ||
| MFH-ino | Growth Inhibition Assay | IC50=0.24692 μM | SANGER | ||
| OE33 | Growth Inhibition Assay | IC50=0.2511 μM | SANGER | ||
| Calu-3 | Growth Inhibition Assay | IC50=0.25297 μM | SANGER | ||
| HT | Growth Inhibition Assay | IC50=0.25621 μM | SANGER | ||
| LXF-289 | Growth Inhibition Assay | IC50=0.25984 μM | SANGER | ||
| KGN | Growth Inhibition Assay | IC50=0.26089 μM | SANGER | ||
| NCI-H1417 | Growth Inhibition Assay | IC50=0.26524 μM | SANGER | ||
| SF126 | Growth Inhibition Assay | IC50=0.27302 μM | SANGER | ||
| SAS | Growth Inhibition Assay | IC50=0.27308 μM | SANGER | ||
| 22RV1 | Growth Inhibition Assay | IC50=0.27378 μM | SANGER | ||
| GI-1 | Growth Inhibition Assay | IC50=0.27487 μM | SANGER | ||
| ES3 | Growth Inhibition Assay | IC50=0.27763 μM | SANGER | ||
| NB1 | Growth Inhibition Assay | IC50=0.27876 μM | SANGER | ||
| NCI-H650 | Growth Inhibition Assay | IC50=0.28302 μM | SANGER | ||
| IST-MES1 | Growth Inhibition Assay | IC50=0.28554 μM | SANGER | ||
| UM-UC-3 | Growth Inhibition Assay | IC50=0.2914 μM | SANGER | ||
| CAL-120 | Growth Inhibition Assay | IC50=0.29631 μM | SANGER | ||
| UACC-62 | Growth Inhibition Assay | IC50=0.30241 μM | SANGER | ||
| TE-11 | Growth Inhibition Assay | IC50=0.30249 μM | SANGER | ||
| MKN1 | Growth Inhibition Assay | IC50=0.3036 μM | SANGER | ||
| KS-1 | Growth Inhibition Assay | IC50=0.30526 μM | SANGER | ||
| GCIY | Growth Inhibition Assay | IC50=0.31002 μM | SANGER | ||
| OVCAR-5 | Growth Inhibition Assay | IC50=0.31106 μM | SANGER | ||
| U-266 | Growth Inhibition Assay | IC50=0.31147 μM | SANGER | ||
| Calu-1 | Growth Inhibition Assay | IC50=0.31289 μM | SANGER | ||
| SK-LMS-1 | Growth Inhibition Assay | IC50=0.31429 μM | SANGER | ||
| COLO-741 | Growth Inhibition Assay | IC50=0.31614 μM | SANGER | ||
| RPMI-8226 | Growth Inhibition Assay | IC50=0.31641 μM | SANGER | ||
| KM12 | Growth Inhibition Assay | IC50=0.3183 μM | SANGER | ||
| NMC-G1 | Growth Inhibition Assay | IC50=0.3186 μM | SANGER | ||
| SJRH30 | Growth Inhibition Assay | IC50=0.32052 μM | SANGER | ||
| COR-L105 | Growth Inhibition Assay | IC50=0.32218 μM | SANGER | ||
| IM-9 | Growth Inhibition Assay | IC50=0.33021 μM | SANGER | ||
| TE-12 | Growth Inhibition Assay | IC50=0.33317 μM | SANGER | ||
| KG-1 | Growth Inhibition Assay | IC50=0.33432 μM | SANGER | ||
| U251 | Growth Inhibition Assay | IC50=0.33456 μM | SANGER | ||
| EFO-27 | Growth Inhibition Assay | IC50=0.33951 μM | SANGER | ||
| EW-24 | Growth Inhibition Assay | IC50=0.33984 μM | SANGER | ||
| SF295 | Growth Inhibition Assay | IC50=0.33999 μM | SANGER | ||
| MC-IXC | Growth Inhibition Assay | IC50=0.345 μM | SANGER | ||
| NCI-H2405 | Growth Inhibition Assay | IC50=0.34732 μM | SANGER | ||
| NCI-H2009 | Growth Inhibition Assay | IC50=0.34739 μM | SANGER | ||
| LB1047-RCC | Growth Inhibition Assay | IC50=0.35815 μM | SANGER | ||
| KNS-81-FD | Growth Inhibition Assay | IC50=0.36667 μM | SANGER | ||
| HOP-92 | Growth Inhibition Assay | IC50=0.3683 μM | SANGER | ||
| L-428 | Growth Inhibition Assay | IC50=0.37016 μM | SANGER | ||
| C3A | Growth Inhibition Assay | IC50=0.37379 μM | SANGER | ||
| NCI-H1792 | Growth Inhibition Assay | IC50=0.37655 μM | SANGER | ||
| HuH-7 | Growth Inhibition Assay | IC50=0.3791 μM | SANGER | ||
| AGS | Growth Inhibition Assay | IC50=0.38638 μM | SANGER | ||
| HT-1197 | Growth Inhibition Assay | IC50=0.3946 μM | SANGER | ||
| CGTH-W-1 | Growth Inhibition Assay | IC50=0.39913 μM | SANGER | ||
| KNS-42 | Growth Inhibition Assay | IC50=0.40045 μM | SANGER | ||
| HuO-3N1 | Growth Inhibition Assay | IC50=0.40055 μM | SANGER | ||
| VMRC-RCZ | Growth Inhibition Assay | IC50=0.40303 μM | SANGER | ||
| SW954 | Growth Inhibition Assay | IC50=0.40335 μM | SANGER | ||
| MES-SA | Growth Inhibition Assay | IC50=0.40505 μM | SANGER | ||
| Ca-Ski | Growth Inhibition Assay | IC50=0.40524 μM | SANGER | ||
| SW13 | Growth Inhibition Assay | IC50=0.40626 μM | SANGER | ||
| NCI-H1437 | Growth Inhibition Assay | IC50=0.40805 μM | SANGER | ||
| U-118-MG | Growth Inhibition Assay | IC50=0.40904 μM | SANGER | ||
| NCI-H1734 | Growth Inhibition Assay | IC50=0.42013 μM | SANGER | ||
| HDLM-2 | Growth Inhibition Assay | IC50=0.42033 μM | SANGER | ||
| AU565 | Growth Inhibition Assay | IC50=0.42468 μM | SANGER | ||
| FADU | Growth Inhibition Assay | IC50=0.42649 μM | SANGER | ||
| OS-RC-2 | Growth Inhibition Assay | IC50=0.43083 μM | SANGER | ||
| CAMA-1 | Growth Inhibition Assay | IC50=0.43626 μM | SANGER | ||
| MONO-MAC-6 | Growth Inhibition Assay | IC50=0.43849 μM | SANGER | ||
| LB831-BLC | Growth Inhibition Assay | IC50=0.44371 μM | SANGER | ||
| SW982 | Growth Inhibition Assay | IC50=0.44528 μM | SANGER | ||
| SCC-3 | Growth Inhibition Assay | IC50=0.44579 μM | SANGER | ||
| C32 | Growth Inhibition Assay | IC50=0.45229 μM | SANGER | ||
| BFTC-909 | Growth Inhibition Assay | IC50=0.45299 μM | SANGER | ||
| MEG-01 | Growth Inhibition Assay | IC50=0.45373 μM | SANGER | ||
| M14 | Growth Inhibition Assay | IC50=0.45979 μM | SANGER | ||
| MPP-89 | Growth Inhibition Assay | IC50=0.46256 μM | SANGER | ||
| HCC1937 | Growth Inhibition Assay | IC50=0.46384 μM | SANGER | ||
| SW837 | Growth Inhibition Assay | IC50=0.46722 μM | SANGER | ||
| DU-145 | Growth Inhibition Assay | IC50=0.46729 μM | SANGER | ||
| LB996-RCC | Growth Inhibition Assay | IC50=0.47054 μM | SANGER | ||
| C8166 | Growth Inhibition Assay | IC50=0.474 μM | SANGER | ||
| MOLT-4 | Growth Inhibition Assay | IC50=0.47734 μM | SANGER | ||
| DMS-53 | Growth Inhibition Assay | IC50=0.47809 μM | SANGER | ||
| TE-5 | Growth Inhibition Assay | IC50=0.48305 μM | SANGER | ||
| KYSE-520 | Growth Inhibition Assay | IC50=0.48343 μM | SANGER | ||
| Detroit562 | Growth Inhibition Assay | IC50=0.4886 μM | SANGER | ||
| SIMA | Growth Inhibition Assay | IC50=0.49417 μM | SANGER | ||
| NCI-H1651 | Growth Inhibition Assay | IC50=0.4967 μM | SANGER | ||
| HCC1599 | Growth Inhibition Assay | IC50=0.49955 μM | SANGER | ||
| ABC-1 | Growth Inhibition Assay | IC50=0.50496 μM | SANGER | ||
| CAL-33 | Growth Inhibition Assay | IC50=0.50844 μM | SANGER | ||
| OPM-2 | Growth Inhibition Assay | IC50=0.50937 μM | SANGER | ||
| RPMI-7951 | Growth Inhibition Assay | IC50=0.50957 μM | SANGER | ||
| HT-1080 | Growth Inhibition Assay | IC50=0.51119 μM | SANGER | ||
| LC4-1 | Growth Inhibition Assay | IC50=0.51403 μM | SANGER | ||
| OVCAR-3 | Growth Inhibition Assay | IC50=0.5157 μM | SANGER | ||
| CAPAN-1 | Growth Inhibition Assay | IC50=0.52288 μM | SANGER | ||
| SK-OV-3 | Growth Inhibition Assay | IC50=0.52434 μM | SANGER | ||
| HuP-T3 | Growth Inhibition Assay | IC50=0.52827 μM | SANGER | ||
| NCI-H838 | Growth Inhibition Assay | IC50=0.52849 μM | SANGER | ||
| K5 | Growth Inhibition Assay | IC50=0.53201 μM | SANGER | ||
| CAL-72 | Growth Inhibition Assay | IC50=0.53387 μM | SANGER | ||
| NH-12 | Growth Inhibition Assay | IC50=0.53959 μM | SANGER | ||
| SNB75 | Growth Inhibition Assay | IC50=0.5573 μM | SANGER | ||
| BPH-1 | Growth Inhibition Assay | IC50=0.56344 μM | SANGER | ||
| NOMO-1 | Growth Inhibition Assay | IC50=0.56372 μM | SANGER | ||
| G-402 | Growth Inhibition Assay | IC50=0.56499 μM | SANGER | ||
| NCI-H2052 | Growth Inhibition Assay | IC50=0.56741 μM | SANGER | ||
| RCM-1 | Growth Inhibition Assay | IC50=0.57166 μM | SANGER | ||
| COR-L279 | Growth Inhibition Assay | IC50=0.57185 μM | SANGER | ||
| A253 | Growth Inhibition Assay | IC50=0.57525 μM | SANGER | ||
| SK-MM-2 | Growth Inhibition Assay | IC50=0.57679 μM | SANGER | ||
| NCI-H1703 | Growth Inhibition Assay | IC50=0.59427 μM | SANGER | ||
| UACC-257 | Growth Inhibition Assay | IC50=0.59487 μM | SANGER | ||
| KALS-1 | Growth Inhibition Assay | IC50=0.60011 μM | SANGER | ||
| ES5 | Growth Inhibition Assay | IC50=0.6048 μM | SANGER | ||
| MHH-CALL-2 | Growth Inhibition Assay | IC50=0.60888 μM | SANGER | ||
| ChaGo-K-1 | Growth Inhibition Assay | IC50=0.61229 μM | SANGER | ||
| TGBC1TKB | Growth Inhibition Assay | IC50=0.6198 μM | SANGER | ||
| KU-19-19 | Growth Inhibition Assay | IC50=0.64586 μM | SANGER | ||
| COLO-684 | Growth Inhibition Assay | IC50=0.65611 μM | SANGER | ||
| LS-1034 | Growth Inhibition Assay | IC50=0.65819 μM | SANGER | ||
| RT-112 | Growth Inhibition Assay | IC50=0.66587 μM | SANGER | ||
| Capan-2 | Growth Inhibition Assay | IC50=0.66622 μM | SANGER | ||
| HSC-4 | Growth Inhibition Assay | IC50=0.66698 μM | SANGER | ||
| COLO-824 | Growth Inhibition Assay | IC50=0.67823 μM | SANGER | ||
| NCI-H2170 | Growth Inhibition Assay | IC50=0.68258 μM | SANGER | ||
| GDM-1 | Growth Inhibition Assay | IC50=0.68494 μM | SANGER | ||
| KP-4 | Growth Inhibition Assay | IC50=0.69573 μM | SANGER | ||
| VA-ES-BJ | Growth Inhibition Assay | IC50=0.69986 μM | SANGER | ||
| KM-H2 | Growth Inhibition Assay | IC50=0.70091 μM | SANGER | ||
| HH | Growth Inhibition Assay | IC50=0.70662 μM | SANGER | ||
| DK-MG | Growth Inhibition Assay | IC50=0.71016 μM | SANGER | ||
| VM-CUB-1 | Growth Inhibition Assay | IC50=0.71259 μM | SANGER | ||
| COLO-829 | Growth Inhibition Assay | IC50=0.71985 μM | SANGER | ||
| OMC-1 | Growth Inhibition Assay | IC50=0.72104 μM | SANGER | ||
| NB12 | Growth Inhibition Assay | IC50=0.72504 μM | SANGER | ||
| NCI-H28 | Growth Inhibition Assay | IC50=0.74083 μM | SANGER | ||
| A673 | Growth Inhibition Assay | IC50=0.75177 μM | SANGER | ||
| LB2241-RCC | Growth Inhibition Assay | IC50=0.76087 μM | SANGER | ||
| CCRF-CEM | Growth Inhibition Assay | IC50=0.77052 μM | SANGER | ||
| NCI-H510A | Growth Inhibition Assay | IC50=0.77186 μM | SANGER | ||
| SW48 | Growth Inhibition Assay | IC50=0.77333 μM | SANGER | ||
| NCI-H2081 | Growth Inhibition Assay | IC50=0.78147 μM | SANGER | ||
| RMG-I | Growth Inhibition Assay | IC50=0.78212 μM | SANGER | ||
| LU-99A | Growth Inhibition Assay | IC50=0.78413 μM | SANGER | ||
| KP-N-YS | Growth Inhibition Assay | IC50=0.78921 μM | SANGER | ||
| MDA-MB-231 | Growth Inhibition Assay | IC50=0.80131 μM | SANGER | ||
| U031 | Growth Inhibition Assay | IC50=0.81423 μM | SANGER | ||
| EVSA-T | Growth Inhibition Assay | IC50=0.81672 μM | SANGER | ||
| MDA-MB-157 | Growth Inhibition Assay | IC50=0.82271 μM | SANGER | ||
| EHEB | Growth Inhibition Assay | IC50=0.82276 μM | SANGER | ||
| KINGS-1 | Growth Inhibition Assay | IC50=0.82555 μM | SANGER | ||
| 23132-87 | Growth Inhibition Assay | IC50=0.82843 μM | SANGER | ||
| EFO-21 | Growth Inhibition Assay | IC50=0.84089 μM | SANGER | ||
| DOK | Growth Inhibition Assay | IC50=0.848 μM | SANGER | ||
| NCI-H2171 | Growth Inhibition Assay | IC50=0.8496 μM | SANGER | ||
| NCI-SNU-5 | Growth Inhibition Assay | IC50=0.8557 μM | SANGER | ||
| SK-N-DZ | Growth Inhibition Assay | IC50=0.85943 μM | SANGER | ||
| SNU-C2B | Growth Inhibition Assay | IC50=0.86801 μM | SANGER | ||
| CP66-MEL | Growth Inhibition Assay | IC50=0.8711 μM | SANGER | ||
| SN12C | Growth Inhibition Assay | IC50=0.88637 μM | SANGER | ||
| A172 | Growth Inhibition Assay | IC50=0.88698 μM | SANGER | ||
| NCI-H2347 | Growth Inhibition Assay | IC50=0.88753 μM | SANGER | ||
| NCI-H2228 | Growth Inhibition Assay | IC50=0.89339 μM | SANGER | ||
| SNU-387 | Growth Inhibition Assay | IC50=0.90264 μM | SANGER | ||
| SK-MEL-24 | Growth Inhibition Assay | IC50=0.91344 μM | SANGER | ||
| MDA-MB-468 | Growth Inhibition Assay | IC50=0.9173 μM | SANGER | ||
| NCI-H1694 | Growth Inhibition Assay | IC50=0.91876 μM | SANGER | ||
| CCF-STTG1 | Growth Inhibition Assay | IC50=0.92637 μM | SANGER | ||
| K052 | Growth Inhibition Assay | IC50=0.94047 μM | SANGER | ||
| NCI-H446 | Growth Inhibition Assay | IC50=0.9501 μM | SANGER | ||
| MFE-280 | Growth Inhibition Assay | IC50=0.96291 μM | SANGER | ||
| KU812 | Growth Inhibition Assay | IC50=0.99389 μM | SANGER | ||
| MDA-MB-361 | Growth Inhibition Assay | IC50=0.99777 μM | SANGER | ||
| Raji | Growth Inhibition Assay | IC50=1.02267 μM | SANGER | ||
| TE-6 | Growth Inhibition Assay | IC50=1.03566 μM | SANGER | ||
| CAL-148 | Growth Inhibition Assay | IC50=1.04443 μM | SANGER | ||
| NCI-H1963 | Growth Inhibition Assay | IC50=1.04553 μM | SANGER | ||
| SK-N-AS | Growth Inhibition Assay | IC50=1.04685 μM | SANGER | ||
| RERF-LC-MS | Growth Inhibition Assay | IC50=1.06349 μM | SANGER | ||
| BEN | Growth Inhibition Assay | IC50=1.07137 μM | SANGER | ||
| CAS-1 | Growth Inhibition Assay | IC50=1.09123 μM | SANGER | ||
| SW780 | Growth Inhibition Assay | IC50=1.09181 μM | SANGER | ||
| LU-65 | Growth Inhibition Assay | IC50=1.0941 μM | SANGER | ||
| D-283MED | Growth Inhibition Assay | IC50=1.12272 μM | SANGER | ||
| HCC2157 | Growth Inhibition Assay | IC50=1.13642 μM | SANGER | ||
| RCC10RGB | Growth Inhibition Assay | IC50=1.14006 μM | SANGER | ||
| PLC-PRF-5 | Growth Inhibition Assay | IC50=1.15229 μM | SANGER | ||
| H4 | Growth Inhibition Assay | IC50=1.15439 μM | SANGER | ||
| TUR | Growth Inhibition Assay | IC50=1.15752 μM | SANGER | ||
| NCI-H2141 | Growth Inhibition Assay | IC50=1.18946 μM | SANGER | ||
| PFSK-1 | Growth Inhibition Assay | IC50=1.20532 μM | SANGER | ||
| SK-MEL-28 | Growth Inhibition Assay | IC50=1.23221 μM | SANGER | ||
| SCC-9 | Growth Inhibition Assay | IC50=1.23665 μM | SANGER | ||
| T47D | Growth Inhibition Assay | IC50=1.23696 μM | SANGER | ||
| TCCSUP | Growth Inhibition Assay | IC50=1.25029 μM | SANGER | ||
| SU-DHL-1 | Growth Inhibition Assay | IC50=1.25118 μM | SANGER | ||
| HL-60 | Growth Inhibition Assay | IC50=1.25588 μM | SANGER | ||
| NCI-H1436 | Growth Inhibition Assay | IC50=1.26149 μM | SANGER | ||
| DMS-114 | Growth Inhibition Assay | IC50=1.26632 μM | SANGER | ||
| BOKU | Growth Inhibition Assay | IC50=1.28095 μM | SANGER | ||
| MS-1 | Growth Inhibition Assay | IC50=1.29069 μM | SANGER | ||
| NCI-H661 | Growth Inhibition Assay | IC50=1.30478 μM | SANGER | ||
| HT-3 | Growth Inhibition Assay | IC50=1.30529 μM | SANGER | ||
| CAL-54 | Growth Inhibition Assay | IC50=1.30725 μM | SANGER | ||
| SW1463 | Growth Inhibition Assay | IC50=1.31872 μM | SANGER | ||
| COLO-668 | Growth Inhibition Assay | IC50=1.33056 μM | SANGER | ||
| PANC-08-13 | Growth Inhibition Assay | IC50=1.33803 μM | SANGER | ||
| BB49-HNC | Growth Inhibition Assay | IC50=1.3401 μM | SANGER | ||
| M059J | Growth Inhibition Assay | IC50=1.35832 μM | SANGER | ||
| NCCIT | Growth Inhibition Assay | IC50=1.37988 μM | SANGER | ||
| LN-405 | Growth Inhibition Assay | IC50=1.39264 μM | SANGER | ||
| UMC-11 | Growth Inhibition Assay | IC50=1.39996 μM | SANGER | ||
| NB5 | Growth Inhibition Assay | IC50=1.41227 μM | SANGER | ||
| TE-441-T | Growth Inhibition Assay | IC50=1.42817 μM | SANGER | ||
| ME-180 | Growth Inhibition Assay | IC50=1.44392 μM | SANGER | ||
| HCC70 | Growth Inhibition Assay | IC50=1.46096 μM | SANGER | ||
| no-10 | Growth Inhibition Assay | IC50=1.46181 μM | SANGER | ||
| JEG-3 | Growth Inhibition Assay | IC50=1.50132 μM | SANGER | ||
| no-11 | Growth Inhibition Assay | IC50=1.50882 μM | SANGER | ||
| CHP-126 | Growth Inhibition Assay | IC50=1.56691 μM | SANGER | ||
| EGI-1 | Growth Inhibition Assay | IC50=1.58025 μM | SANGER | ||
| D-392MG | Growth Inhibition Assay | IC50=1.5963 μM | SANGER | ||
| RT4 | Growth Inhibition Assay | IC50=1.59637 μM | SANGER | ||
| A204 | Growth Inhibition Assay | IC50=1.59801 μM | SANGER | ||
| NCI-H1304 | Growth Inhibition Assay | IC50=1.63591 μM | SANGER | ||
| Becker | Growth Inhibition Assay | IC50=1.64241 μM | SANGER | ||
| OE19 | Growth Inhibition Assay | IC50=1.65518 μM | SANGER | ||
| EKVX | Growth Inhibition Assay | IC50=1.65618 μM | SANGER | ||
| KLE | Growth Inhibition Assay | IC50=1.65714 μM | SANGER | ||
| K-562 | Growth Inhibition Assay | IC50=1.67037 μM | SANGER | ||
| MDA-MB-175-VII | Growth Inhibition Assay | IC50=1.68997 μM | SANGER | ||
| NCI-H716 | Growth Inhibition Assay | IC50=1.69304 μM | SANGER | ||
| Caov-3 | Growth Inhibition Assay | IC50=1.69413 μM | SANGER | ||
| HCC1187 | Growth Inhibition Assay | IC50=1.70545 μM | SANGER | ||
| CAKI-1 | Growth Inhibition Assay | IC50=1.72292 μM | SANGER | ||
| MOLT-16 | Growth Inhibition Assay | IC50=1.73307 μM | SANGER | ||
| PC-3 | Growth Inhibition Assay | IC50=1.7508 μM | SANGER | ||
| DV-90 | Growth Inhibition Assay | IC50=1.75585 μM | SANGER | ||
| RXF393 | Growth Inhibition Assay | IC50=1.77294 μM | SANGER | ||
| SK-NEP-1 | Growth Inhibition Assay | IC50=1.82339 μM | SANGER | ||
| HCC1419 | Growth Inhibition Assay | IC50=1.82692 μM | SANGER | ||
| BV-173 | Growth Inhibition Assay | IC50=1.82995 μM | SANGER | ||
| MKN7 | Growth Inhibition Assay | IC50=1.8922 μM | SANGER | ||
| LAN-6 | Growth Inhibition Assay | IC50=1.89553 μM | SANGER | ||
| Mo-T | Growth Inhibition Assay | IC50=1.90039 μM | SANGER | ||
| HCC1395 | Growth Inhibition Assay | IC50=1.92863 μM | SANGER | ||
| HC-1 | Growth Inhibition Assay | IC50=1.9347 μM | SANGER | ||
| HPAF-II | Growth Inhibition Assay | IC50=1.94418 μM | SANGER | ||
| CPC-N | Growth Inhibition Assay | IC50=1.98002 μM | SANGER | ||
| MKN45 | Growth Inhibition Assay | IC50=1.99119 μM | SANGER | ||
| NCI-H1693 | Growth Inhibition Assay | IC50=2.00433 μM | SANGER | ||
| SHP-77 | Growth Inhibition Assay | IC50=2.00533 μM | SANGER | ||
| NCI-H1522 | Growth Inhibition Assay | IC50=2.01724 μM | SANGER | ||
| SW1573 | Growth Inhibition Assay | IC50=2.022 μM | SANGER | ||
| DBTRG-05MG | Growth Inhibition Assay | IC50=2.06087 μM | SANGER | ||
| SCC-4 | Growth Inhibition Assay | IC50=2.1431 μM | SANGER | ||
| DMS-153 | Growth Inhibition Assay | IC50=2.16668 μM | SANGER | ||
| MDA-MB-415 | Growth Inhibition Assay | IC50=2.1752 μM | SANGER | ||
| NCI-H2126 | Growth Inhibition Assay | IC50=2.22888 μM | SANGER | ||
| MDA-MB-453 | Growth Inhibition Assay | IC50=2.2332 μM | SANGER | ||
| U-87-MG | Growth Inhibition Assay | IC50=2.28592 μM | SANGER | ||
| LNCaP-Clone-FGC | Growth Inhibition Assay | IC50=2.30102 μM | SANGER | ||
| NCI-H1581 | Growth Inhibition Assay | IC50=2.32105 μM | SANGER | ||
| BC-3 | Growth Inhibition Assay | IC50=2.36509 μM | SANGER | ||
| HCC38 | Growth Inhibition Assay | IC50=2.38447 μM | SANGER | ||
| HCC2218 | Growth Inhibition Assay | IC50=2.40809 μM | SANGER | ||
| RO82-W-1 | Growth Inhibition Assay | IC50=2.4125 μM | SANGER | ||
| C2BBe1 | Growth Inhibition Assay | IC50=2.41578 μM | SANGER | ||
| LAMA-84 | Growth Inhibition Assay | IC50=2.57368 μM | SANGER | ||
| GMS-10 | Growth Inhibition Assay | IC50=2.57611 μM | SANGER | ||
| GCT | Growth Inhibition Assay | IC50=2.58694 μM | SANGER | ||
| SK-CO-1 | Growth Inhibition Assay | IC50=2.6166 μM | SANGER | ||
| NCI-H526 | Growth Inhibition Assay | IC50=2.6345 μM | SANGER | ||
| SW1088 | Growth Inhibition Assay | IC50=2.77839 μM | SANGER | ||
| HT55 | Growth Inhibition Assay | IC50=2.78695 μM | SANGER | ||
| NB10 | Growth Inhibition Assay | IC50=2.81748 μM | SANGER | ||
| UACC-893 | Growth Inhibition Assay | IC50=2.85749 μM | SANGER | ||
| NCI-H1618 | Growth Inhibition Assay | IC50=2.88153 μM | SANGER | ||
| NCI-H1092 | Growth Inhibition Assay | IC50=3.07812 μM | SANGER | ||
| SBC-1 | Growth Inhibition Assay | IC50=3.08553 μM | SANGER | ||
| NCI-H1623 | Growth Inhibition Assay | IC50=3.0934 μM | SANGER | ||
| SiHa | Growth Inhibition Assay | IC50=3.11977 μM | SANGER | ||
| D-263MG | Growth Inhibition Assay | IC50=3.14788 μM | SANGER | ||
| NCI-H1573 | Growth Inhibition Assay | IC50=3.19641 μM | SANGER | ||
| NCI-H82 | Growth Inhibition Assay | IC50=3.34439 μM | SANGER | ||
| NCI-H2196 | Growth Inhibition Assay | IC50=3.35008 μM | SANGER | ||
| MFM-223 | Growth Inhibition Assay | IC50=3.37351 μM | SANGER | ||
| COLO-678 | Growth Inhibition Assay | IC50=3.38186 μM | SANGER | ||
| EW-3 | Growth Inhibition Assay | IC50=3.4095 μM | SANGER | ||
| MHH-NB-11 | Growth Inhibition Assay | IC50=3.44069 μM | SANGER | ||
| EM-2 | Growth Inhibition Assay | IC50=3.6398 μM | SANGER | ||
| FTC-133 | Growth Inhibition Assay | IC50=3.65458 μM | SANGER | ||
| NCI-H209 | Growth Inhibition Assay | IC50=3.67653 μM | SANGER | ||
| TGBC24TKB | Growth Inhibition Assay | IC50=3.68355 μM | SANGER | ||
| LC-1F | Growth Inhibition Assay | IC50=3.71764 μM | SANGER | ||
| C-4-II | Growth Inhibition Assay | IC50=3.75643 μM | SANGER | ||
| NCI-H1650 | Growth Inhibition Assay | IC50=3.78455 μM | SANGER | ||
| JVM-2 | Growth Inhibition Assay | IC50=3.93639 μM | SANGER | ||
| CaR-1 | Growth Inhibition Assay | IC50=3.97617 μM | SANGER | ||
| MDA-MB-134-VI | Growth Inhibition Assay | IC50=4.02952 μM | SANGER | ||
| NCI-H719 | Growth Inhibition Assay | IC50=4.15388 μM | SANGER | ||
| GOTO | Growth Inhibition Assay | IC50=4.29705 μM | SANGER | ||
| NCI-N87 | Growth Inhibition Assay | IC50=4.38821 μM | SANGER | ||
| NB6 | Growth Inhibition Assay | IC50=4.42509 μM | SANGER | ||
| DSH1 | Growth Inhibition Assay | IC50=4.47116 μM | SANGER | ||
| BT-20 | Growth Inhibition Assay | IC50=4.49002 μM | SANGER | ||
| NCI-H1882 | Growth Inhibition Assay | IC50=4.5057 μM | SANGER | ||
| WM-115 | Growth Inhibition Assay | IC50=4.50881 μM | SANGER | ||
| SKG-IIIa | Growth Inhibition Assay | IC50=4.6777 μM | SANGER | ||
| NCI-H69 | Growth Inhibition Assay | IC50=4.70275 μM | SANGER | ||
| MSTO-211H | Growth Inhibition Assay | IC50=4.83565 μM | SANGER | ||
| Mewo | Growth Inhibition Assay | IC50=4.96313 μM | SANGER | ||
| GI-ME-N | Growth Inhibition Assay | IC50=5.00509 μM | SANGER | ||
| T98G | Growth Inhibition Assay | IC50=5.06508 μM | SANGER | ||
| ECC4 | Growth Inhibition Assay | IC50=5.09372 μM | SANGER | ||
| EW-11 | Growth Inhibition Assay | IC50=5.18099 μM | SANGER | ||
| COLO-800 | Growth Inhibition Assay | IC50=5.19349 μM | SANGER | ||
| NCI-H1755 | Growth Inhibition Assay | IC50=5.23027 μM | SANGER | ||
| KMS-12-PE | Growth Inhibition Assay | IC50=5.35085 μM | SANGER | ||
| HCC1954 | Growth Inhibition Assay | IC50=5.85971 μM | SANGER | ||
| NCI-H187 | Growth Inhibition Assay | IC50=5.92989 μM | SANGER | ||
| LU-165 | Growth Inhibition Assay | IC50=5.99002 μM | SANGER | ||
| YAPC | Growth Inhibition Assay | IC50=5.99068 μM | SANGER | ||
| LU-139 | Growth Inhibition Assay | IC50=6.08368 μM | SANGER | ||
| D-502MG | Growth Inhibition Assay | IC50=6.32047 μM | SANGER | ||
| IST-SL1 | Growth Inhibition Assay | IC50=6.53948 μM | SANGER | ||
| DG-75 | Growth Inhibition Assay | IC50=6.88786 μM | SANGER | ||
| NCI-H1155 | Growth Inhibition Assay | IC50=6.95581 μM | SANGER | ||
| EFE-184 | Growth Inhibition Assay | IC50=7.31695 μM | SANGER | ||
| AsPC-1 | Growth Inhibition Assay | IC50=7.48807 μM | SANGER | ||
| SW948 | Growth Inhibition Assay | IC50=7.58395 μM | SANGER | ||
| NCI-H524 | Growth Inhibition Assay | IC50=9.58628 μM | SANGER | ||
| KOSC-2 | Growth Inhibition Assay | IC50=9.62834 μM | SANGER | ||
| T-24 | Growth Inhibition Assay | IC50=9.94415 μM | SANGER | ||
| NCI-H748 | Growth Inhibition Assay | IC50=10.6397 μM | SANGER | ||
| NCI-H23 | Growth Inhibition Assay | IC50=10.6442 μM | SANGER | ||
| UACC-812 | Growth Inhibition Assay | IC50=11.717 μM | SANGER | ||
| SCLC-21H | Growth Inhibition Assay | IC50=12.1551 μM | SANGER | ||
| NCI-SNU-16 | Growth Inhibition Assay | IC50=13.1258 μM | SANGER | ||
| HD-MY-Z | Growth Inhibition Assay | IC50=14.6363 μM | SANGER | ||
| SK-N-FI | Growth Inhibition Assay | IC50=14.8912 μM | SANGER | ||
| LB647-SCLC | Growth Inhibition Assay | IC50=15.7195 μM | SANGER | ||
| NCI-H345 | Growth Inhibition Assay | IC50=17.343 μM | SANGER | ||
| NCI-H1563 | Growth Inhibition Assay | IC50=18.7601 μM | SANGER | ||
| RL | Growth Inhibition Assay | IC50=21.2656 μM | SANGER | ||
| KY821 | Growth Inhibition Assay | IC50=22.0553 μM | SANGER | ||
| JVM-3 | Growth Inhibition Assay | IC50=25.0413 μM | SANGER | ||
| NCI-H1793 | Growth Inhibition Assay | IC50=28.5499 μM | SANGER | ||
| LU-134-A | Growth Inhibition Assay | IC50=30.2037 μM | SANGER | ||
| NCI-H1395 | Growth Inhibition Assay | IC50=32.2431 μM | SANGER | ||
| NCI-H1993 | Growth Inhibition Assay | IC50=32.8218 μM | SANGER | ||
| P31-FUJ | Growth Inhibition Assay | IC50=33.4899 μM | SANGER | ||
| LS-513 | Growth Inhibition Assay | IC50=35.8879 μM | SANGER | ||
| SK-MEL-1 | Growth Inhibition Assay | IC50=40.3499 μM | SANGER | ||
| SW684 | Growth Inhibition Assay | IC50=43.9661 μM | SANGER | ||
| COR-L88 | Growth Inhibition Assay | IC50=44.0665 μM | SANGER | ||
| NCI-H889 | Growth Inhibition Assay | IC50=45.0087 μM | SANGER | ||
| TALL-1 | Growth Inhibition Assay | IC50=46.1199 μM | SANGER | ||
| KARPAS-299 | Growth Inhibition Assay | IC50=47.1993 μM | SANGER | ||
| 点击查看更多细胞系数据 | |||||
生物活性
| 产品描述 | Obatoclax Mesylate (GX15-070)是一种Bcl-2拮抗剂，无细胞试验中Ki为0.22 μM，可以协助抑制MCL-1介导的抗细胞凋亡作用。 | ||
|---|---|---|---|
| 特性 | Obatoclax是有应用前景的小分子Bcl-2拮抗剂，抑制Bcl-2蛋白家族所有相关的膜结构，包括 Mcl-1。 | ||
| 靶点 |
|
| 体外研究(In Vitro) | ||||
| 体外研究活性 | 5 μM Obatoclax作用于SK-Mel5细胞完全抑制Mcl-1参与的Bak修复，且阻断由Mcl-1引起的抗ABT-373诱导的KB/Bcl-2细胞凋亡。 [1] Obatoclax是拟BH3，可以与许多Bcl-2家族成员结合，包括Bcl-2, Bcl-xL,和Mcl-1。Obatoclax特异取代Mcl-1的激活BH3域，随后引起Bak低聚反应和细胞色素C释放调节的细胞凋亡。Obatoclax可有效作用于缺乏Bcl-xL或Bcl-xL低表达的细胞系，Obatoclax作用于所有强表达Mcl-1, Bcl-2,和Bcl-xL的细胞系时显示出较低的细胞毒性。Obatoclax抑制多发性骨髓瘤细胞（MM）系如KMS12PE, KMS18, MY5等等，IC50值为52到1100nM。当有浓度为150 nmol的抗细胞毒素剂IL-6 或IGF-1存在时，也可观察到抑制作用。Obatoclax增强melphalan, dexamethasone,或bortezomib的抗骨髓瘤活性。 [2] Obatoclax加强肿瘤坏死因子相关凋亡诱导配体（TRAIL）调节的细胞凋亡。 [3] |
|||
|---|---|---|---|---|
| 激酶实验 | Bcl-2 结合实验 | |||
| 使用SIE计分函数计算Obatoclaxs与BCL-2的结合力。[4] 为了确定实验的准确性，计算一组12个小分子与BCL-2的结合亲和力。 | ||||
| 细胞实验 | 细胞系 | 人类多发性骨髓瘤细胞（MM），外周血淋巴细胞(PBLs)，及髓基质细胞(BMSCs) | ||
| 浓度 | 10 μM 左右 | |||
| 孵育时间 | 48-72小时 | |||
| 方法 | Obatoclax溶解在DMSO中，浓度为5 mM。通过MTT实验测细胞活力。人类多发性骨髓瘤细胞（MM），外周血淋巴细胞(PBLs)，及髓基质细胞(BMSCs)按每孔2x104(HMCLs) 或5~10x103(PBLs)密度接种在96孔板上。加入不同浓度的Obatoclax，实验组加入IGF-1(50 ng/mL)或IL-6(10 ng/mL)，对照组不加。细胞温育48到72小时，测定细胞活力。 |
|||
| 实验图片 | 检测方法 | 检测指标 | 实验图片 | PMID |
| Western blot | Cyclin D1 / p27 Kip1 p-Cyclin D1 p-GSK3β / GSK3β / p-ERK / ERK / p-p38 / p38 |
|
28382170 | |
| Growth inhibition assay | Cell proliferation Cell viability |
|
28035994 | |
| 体内研究(In Vivo) | ||
| 体内研究活性 |
Obatoclax作用于携带人类C33A 子宫瘤的SCID鼠，按鼠体重，每千克处理0.5 mg Obatoclax，结果显示强抗癌活性。[1] |
|
|---|---|---|
| 动物实验 | Animal Models | 携带SW480, C33A, PC3,和4T1细胞的雌性BALB/c 或CB17 SCID/SCID鼠。 |
| Dosages | 0.0313, 0.25, 0.5，和2 mg/kg | |
| Administration | 在鼠尾部静脉注射，每天一次。 | |
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT00438178 | Completed | Hematological Malignancies |
Gemin X|Teva Branded Pharmaceutical Products R&D Inc. |
October 2005 | Phase 1 |
| NCT00600964 | Completed | Chronic Lymphocytic Leukemia |
Gemin X|Teva Branded Pharmaceutical Products R&D Inc. |
September 2004 | Phase 1 |
化学信息&溶解度
| 分子量 | 413.49 | 分子式 | C20H19N3O.CH4O3S |
| CAS号 | 803712-79-0 | SDF | Download Obatoclax Mesylate (GX15-070) SDF |
| Smiles | CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O | ||
| 储存条件(自收到货起) | |||
|
体外溶解度 |
DMSO : 83 mg/mL ( (200.73 mM)； DMSO吸湿会降低化合物溶解度，请使用新开封DMSO) Water : Insoluble Ethanol : Insoluble |
摩尔浓度计算器 |
|
体内溶解度 现配现用，请按从左到右的顺序依次添加，澄清后再加入下一溶剂 |
动物体内配方计算器 | ||||
实验计算
动物体内配方计算器（澄清溶液）
第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）
mg/kg
g
μL
只
第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
计算结果：
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；
体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH2O，混匀澄清。
体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。
注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
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