Palbociclib (PD-0332991) HCl

Pfizer辉瑞授权 目录号:S1116

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。

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RMB 902.49 现货
RMB 1406.17 现货
RMB 4670.26 现货
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客户使用该产品的9个实验数据:

  • PD-0332991 causes inhibition of proliferation of EAC cells in a dose-dependent manner. Western blots showing the phosphorylation status of pRB at Ser780 and Ser795 after incubation with 125 nmol/L PD-0332991 for 24 and 72 hours. Reduction in cyclin A expression and the expression of RB2 (p130) tumor suppressor 72 hours after PD-0332991 treatment are shown (bottom). Total pRB (RB1) and actin are loading controls and T293 cell lysate (293) is a positive control for total pRB and phospho-pRB (Ph-RB). E, anchorage-independent growth of the 3 cell lines in the presence or absence (Cnt) of 125 nmol/L PD-0332991 for 3 weeks.

    Clin Cancer Res 2011 17(13), 4513-22. Palbociclib (PD-0332991) HCl purchased from Selleck.

    b, c MelJuso cells were treated for 12–48 h with 1 µM Selumetinib or 5 µM Palbociclib and the cells were fixed, stained with propidium iodide and cell cycle distribution was determined by flow cytometry (b) and whole cell extracts were fractionated by SDS-PAGE, transferred onto PVDF membrane and immuno-blotted with the indicated antibodies (c). Data is from a single experiment representative of three separate experiments with similar results. The data in (b) are mean ± S.D. from a single experiment with three replicate dishes of cell per data point; similar results were obtained in two additional experiments

    Cell Mol Life Sci, 2016, 73(4):883-900. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • (A) Percentage of DN3a cells in S-phase (as gated on DAPI profile) from control (Zfp36l1/2fl/fl) and Zfp36l1/2fl/fl; CD2Cre (DCKO) mice, after 1 d of treatment with vector or palbociclib (drug).

    J Immunol, 2016, 197(7):2673-85. Palbociclib (PD-0332991) HCl purchased from Selleck.

     

    Patient tumor cell sensitivity to combinatorial treatment with histone deacetylase (HDAC)/cyclin-dependent kinase (CDK) inhibitors in 3-D culture. The effect of each drug or drug combination was assessed by fluorescent dye to identify live (green) and dead cells (red). Cells from breast reduction patients were used as non-cancer control in the assay.

    Pharmacogenomics J 2013 13(1), 94-104. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • The expression of respective proteins in CDK4/6-Rb-apoptosis pathway in cells was examined by Western blot after 3 days of palbociclib treatment.

    Biochim Biophys Acta, 2018, 1864(5 Pt A):1573-1582. Palbociclib (PD-0332991) HCl purchased from Selleck.

     

    Cdk4 is upregulated in ARMS and mMSCs transfected with PAX7-FKHR fusion gene (MP7F), and can be specifi cally inhibited. D: IF results showing overexpression of cdk4 in MP7F cells compared to parental mMSCs and reduced expression of cdk4 after treatment of MP7F cells with the cdk4 inhibitor, PD-0332991. E: IF results showing MyoD1 expression in parental mMSCs cells, and MP7F cells untreated and after treatment with the cdk4 inhibitor, PD-0332991.

    Clin Transl Oncol 2012 14(3), 197-206 . Palbociclib (PD-0332991) HCl purchased from Selleck.

  • WM3734 melanoma cells were treated by PD-0332991 for 36 hours; melanoma cells treated by Doxorubicin (DXR)  at 0.5 μM is included as a control.

     

     

    Dr. Gao Zhang of University of Pennsylvania. Palbociclib (PD-0332991) HCl purchased from Selleck.

    Serum-deprived T98G glioma cells are restimulated with serum(FBS) with or without 1 μΜ PD-0332991.

     

     

    Dr. Sabine Paternot and Dr Pierre Roger of IRIBHM, ULB, Brussels. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • P16INK4A knockdown in INK4A/ARF-wt human glioma cell LN319 potentiates PDGF-Apromoted anchorage-dependent growth in vitro. Soft agar growth of Ink4a/Arf-deficient mAst and LN444 cells treated with PD0332991. (A) IB analysis. (B) Quantification of soft agar assays. β-actin was used as a loading control in all IB experiments. Data are presented as mean ± s.d. and representative of two independent experiments. **, P < 0.01; ***, P < 0.001

    Dr. Kun-Wei Liu from University of Pittsburgh. Palbociclib (PD-0332991) HCl purchased from Selleck.

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。
特性 PD-0332991作为有应用前景的工具测定CDK激酶是否具有明显的治疗价值。
靶点
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外研究

PD 0332991 对其他蛋白激酶包括EGFR, FGFR, PGFR, IR等没有抑制效果。 PD 0332991作用于Cdk4时是非ATP竞争性抑制剂。PD 0332991抑制MDA-MB-435乳腺癌细胞,IC50为66 nM,是由于Rb 在Ser780的磷酸化作用下降。PD 0332991抑制胸苷合并到Rb阳性的人类乳腺癌,结肠癌 肺癌,及白血病的DNA中,IC50值为4 nM到0.17 μM。PD 0332991作用于Rb阴性细胞没有抑制效果。PD 0332991作用于MDA-MB-453乳腺癌细胞和结肠-205细胞使细胞积累在G1期。[1]PD 0332991也有效作用于骨髓瘤5T33MM细胞,使细胞对Bortezomib敏感。[2]PD 0332991抑制luminalER-阳性和HER2-增强的乳腺癌细胞系,包括MDA-MB-175 ZR-75-30 CAMA-1 MDA-MB-134 HCC-202 UACC-893 等等。在这些细胞系中,PD 0332991增强Tamoxifen和Trastuzumab 的活性。在MCF7抗Tamoxifen细胞中,PD 0332991也增强tamoxifen 的敏感性。[3] 最新研究显示PD 0332991可以抑制恶性横纹肌样肿瘤(MRT)细胞系包括MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS,且MRT细胞系对PD 0332991敏感性和p16表达呈负相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 MUPLbY5ie2ViQYPzZZk> M{nkVFI1KGh? NIDE[JpKdmirYnn0bY9vKG:oIFPET|Qh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBT[iCyaH;zdIhwenmuYYTpc44hf2m2aDDJR|UxKG:oIECuNFAzKM7:TR?= NVToWVY5OjR4NEGxNFM>
COLO205 NVnmOIxCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnoZXBqPzJiaB?= NGLn[ohCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEO2JO69VQ>? NHjMbVMzPDZ2MUGwNy=>
U937 NIrDPY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj3fGU4OiCq NVXHSlh7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX7jc5Jxd3KjdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlvfG9iRF7BJJdqfGhiSVO1NEBw\iByLkG0JO69VQ>? Mlf2NlQ3PDFzMEO=
MOLM13 NVfDXodVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17RWFczKGh? MWTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2RTF2xN{Bk\WyuczDoZZJjd3KrbnegSmxVOyCLVFSgcZV1[W62IHHzd4V{e2WmIHHzJIlv[2:{cH;yZZRqd25ib3[gX|NJZXSqeX3p[Ilv\SCrboTvJGRPSSC5aYToJGlEPTBib3[gNE4xQTZizszN NV\Q[nI4OjR4NEGxNFM>
MOLM13 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:3NkBp Mle5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDzc5Ji\mWwaXKtdoV{cXO2YX70JIh2dWGwIF3PUG0yOyClZXzsd{Bie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEm2JO69VQ>? M3ruUVI1PjRzMUCz
MDA-MB-435 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P4XVI1KGh? NFSwb|hKSzVyPUCuNVYh|ryP MVuxOVgxOTh|MR?=
K562 NGP2TXREgXSxdH;4bYMhSXO|YYm= MWK5OkBp MVTEUXNQ NXW0dnAyUUN3ME2yJO69VQ>? NX:4OGFJOjR2MUe1OlY>
DU145 NYPUdpFtS3m2b4TvfIlkKEG|c3H5 NWrxRXlqQTZiaB?= Mn3CSG1UVw>? MlnqTWM2OD15LkWg{txO M3\IfVI1PDF5NU[2
MDA-MB-231 Mn\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGL3Wo0yKM7:TR?= MorFNlQhcA>? MXrEUXNQ MV;D[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|EheGijc3W= MVWyOFQyPzV4Nh?=
MCF7 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;LNUDPxE1? NH6xTokzPCCq M1zQfGROW09? NUHpR|ZvS2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdzIIDoZZNm MXiyOFQyPzV4Nh?=
MCF7 M3XWfWtqdmG|ZTDBd5NigQ>? NXOzfW1HPSEQvF2= MofGNlQhcA>? NGnhXnhFVVOR NI\NRWVKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGNFUzRxY4njcIlvTDFiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC{ZYTpco9jdGG|dH;tZUBxcG:|cHjvdplt[XSrb36gZZQhW2W{N{iw M{fpUlI1PDF5NU[2
MDA-MB-231 Mm\2T4lv[XOnIFHzd4F6 MW[1JO69VQ>? Ml;0NlQhcA>? NXvHdmloTE2VTx?= M3i2UmlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgR2RMPC:leXPsbY5FOSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKndHnuc4Jt[XO2b33hJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OEC= MWiyOFQyPzV4Nh?=
MDA-MB-231 MkfNSpVv[3Srb36gRZN{[Xl? NFfReYoyNTFyIN88US=> NGrZXoIzPCCq MWDEUXNQ M2nXR4Rw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhWEGUUDDjcIVifmGpZR?= M4XTZlI1PDF5NU[2
MCF7 MVvGeY5kfGmxbjDBd5NigQ>? M4\sSlEuOTBizszN MkHwNlQhcA>? MnXBSG1UVw>? MmS5[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BRSVKSIHPs[YF3[Wen NWHUVWpJOjR2MUe1OlY>
MDA-MB-231 NVW0flJNTnWwY4Tpc44hSXO|YYm= NHL0XWExNjVvMTFOwG0> NXrWUYtJPDhiaB?= NXPCTXg3TE2VTx?= NV\JR29ycGG|IH7vJGNmdGxiY4njcIUh[XK{ZYP0JIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEB{fWJvR{GgdIhie2V? MVmyOFQyPzV4Nh?=
MCF7 NGm2[2VHfW6ldHnvckBCe3OjeR?= NXfycWtoOC53LUGg{txO MYK0PEBp NIDGdm5FVVOR NH72PHNp[XNibn:gR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMTDwbIF{\Q>? NInoPXEzPDRzN{W2Oi=>
697 M1TjSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PtTWlEPTB;MUS4MlM5KG6P MmTvV2FPT0WU
P12-ICHIKAWA MkPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7sT2pLUUN3ME25Ok4xPCCwTR?= MY\TRW5ITVJ?
NB69 NY[1fXgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTF4MT64JI5O NW\0bHdYW0GQR1XS
EoL-1 NXfvNYJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTF6Nz6yOkBvVQ>? NEfxTndUSU6JRWK=
BHT-101 MmTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHGTWM2OD1zOUiuNlUhdk1? NH:3cm1USU6JRWK=
SK-NEP-1 NVfocIpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonBTWM2OD1{MkCuNFIhdk1? M2eydHNCVkeHUh?=
MHH-NB-11 MoDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVm5S5BuUUN3ME2yNlAvOTlibl2= MVLTRW5ITVJ?
AsPC-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH0WYtKSzVyPUK1Nk42OyCwTR?= M1HLNHNCVkeHUh?=
ES1 M3\MbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTJ3Nj6yOUBvVQ>? MnLiV2FPT0WU
LAMA-84 M3flTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4f2SWlEPTB;MkW4MlE6KG6P MlSyV2FPT0WU
MOLT-16 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL3TWM2OD1{NUiuOFkhdk1? M3;VNnNCVkeHUh?=
ES7 M3jrVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJ5Mz6wPUBvVQ>? MorzV2FPT0WU
KY821 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2f5R2lEPTB;M{G0MlEhdk1? NGDoe4JUSU6JRWK=
RT-112 M1PPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTN{MT6wOUBvVQ>? NFHQWlJUSU6JRWK=
HL-60 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\Ud3NKSzVyPUO0NE43PiCwTR?= MoLKV2FPT0WU
MOLT-4 NIf3Z|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LicmlEPTB;M{S1MlE{KG6P MnvjV2FPT0WU
KARPAS-45 M{TDWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{njfWlEPTB;M{e2MlE3KG6P M1\NSXNCVkeHUh?=
SK-N-AS M33xTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\mVIpKSzVyPUO4O{45OyCwTR?= MUDTRW5ITVJ?
CTB-1 NXnCfVFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTRyNT6wNkBvVQ>? NEjre4JUSU6JRWK=
NKM-1 MmruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLoUYRKSzVyPUSxNU45QSCwTR?= M{PGZ3NCVkeHUh?=
HTC-C3 NHrUR3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlG4TWM2OD12M{KuPVUhdk1? MnPLV2FPT0WU
BE-13 M12zXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTyTWM2OD12NESuNlchdk1? M4jHSHNCVkeHUh?=
KOSC-2 MofDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrXTWM2OD12Nk[uPUBvVQ>? MnHVV2FPT0WU
NB14 MmD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPETWM2OD12OEOuOVghdk1? NYXWZpVHW0GQR1XS
CAL-27 NWjFUFVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;ETWM2OD12OUSuOVkhdk1? NXfvU|czW0GQR1XS
H9 NVjDfJlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTR7NT60N{BvVQ>? Mn7BV2FPT0WU
RS4-11 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\GO4hmUUN3ME21NFQvPzNibl2= MoPIV2FPT0WU
PA-1 M4TxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi1SGNDUUN3ME21NFkvQDZibl2= Ml;iV2FPT0WU
MV-4-11 NXXjTFZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HsUWlEPTB;NUGzMlg2KG6P NHX6V45USU6JRWK=
OS-RC-2 MoP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2riSmlEPTB;NUKxMlYzKG6P NEDQTlVUSU6JRWK=
RPMI-8226 MofsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTV{Nj64OkBvVQ>? M2jXXHNCVkeHUh?=
HGC-27 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTV4ND65PUBvVQ>? M3n0XXNCVkeHUh?=
CHP-212 NFfjXZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvp[oNKSzVyPUW5N{42QSCwTR?= NXT6dWtXW0GQR1XS
NB10 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm3fldKSzVyPUW5PU4yQCCwTR?= NGL3S4FUSU6JRWK=
HH M3LQSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X4VmlEPTB;NUm5MlQ{KG6P MkmzV2FPT0WU
EW-16 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTZyMz61NkBvVQ>? NX;DfHVtW0GQR1XS
ES8 Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTZyNT6yNUBvVQ>? MlHlV2FPT0WU
HAL-01 M{XUe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\UfoRKSzVyPU[wOU43PyCwTR?= NGHFUVJUSU6JRWK=
A204 NF:3SYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3tOYt4UUN3ME22N|MvQTFibl2= NIXvcHJUSU6JRWK=
MHH-PREB-1 MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnZdog2UUN3ME22N|YvQTlibl2= MWrTRW5ITVJ?
EM-2 NV\jNpZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYKwfnNTUUN3ME22OVAvPjRibl2= MnTUV2FPT0WU
BV-173 MoXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTZ3Mj60PEBvVQ>? Mnz1V2FPT0WU
ONS-76 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTOS4dsUUN3ME22O|cvQDJibl2= M{nle3NCVkeHUh?=
KM-H2 NFPodIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\JZmlEPTB;Nkm1MlU1KG6P NYHmPWdLW0GQR1XS
D-263MG M2[2dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:ydWlEPTB;N{G3MlEzKG6P MYnTRW5ITVJ?
ES3 Mn3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlftTWM2OD15MkiuPVMhdk1? MVHTRW5ITVJ?
VA-ES-BJ M1LpXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXQcYlKSzVyPUezNk4zPyCwTR?= M1nxXHNCVkeHUh?=
NBsusSR MkLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVr6SXB{UUN3ME23OFIvQTlibl2= NUPzVJVtW0GQR1XS
NCI-H520 M4O0Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDGTnVKSzVyPUe0Ok42OiCwTR?= MWDTRW5ITVJ?
ES5 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTd3Mj64JI5O MXvTRW5ITVJ?
T-24 MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[0R4tmUUN3ME23O|gvPzFibl2= M{fRbXNCVkeHUh?=
SW962 MlPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYS1WGZRUUN3ME24NFgvPjNibl2= NEjpZmVUSU6JRWK=
EW-3 NGH1U|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XuPWlEPTB;OEC4Mlc3KG6P NWL1fm97W0GQR1XS
RXF393 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRThzMj63PUBvVQ>? NFzwN4VUSU6JRWK=
U251 NXXmWnF2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLldIszUUN3ME24NVMvQDhibl2= MmjyV2FPT0WU
CAMA-1 NGTDeY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfyVnRKSzVyPUizN{46PCCwTR?= MljVV2FPT0WU
JVM-3 MlK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTh3MT63PEBvVQ>? NV\nSnpoW0GQR1XS
COLO-800 NV\PNnVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1j6WWlEPTB;OEm3Mlc5KG6P M{LSUHNCVkeHUh?=
OVCAR-5 NUOwSId[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\rZ5dDUUN3ME25NFAvOSCwTR?= M3HpfXNCVkeHUh?=
LB1047-RCC MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFezWWVKSzVyPUmyO{42PiCwTR?= MmPUV2FPT0WU
SW954 M2nmSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGyfGVGUUN3ME25NlkvPDFibl2= M3ztUHNCVkeHUh?=
J-RT3-T3-5 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnhXlZKSzVyPUmzOk4xPiCwTR?= NULjWXVJW0GQR1XS
Mewo NYLFXGdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTl|Nj62JI5O NEnKW|dUSU6JRWK=
NCI-H1770 M4rmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTl2MD61OUBvVQ>? MmDrV2FPT0WU
HO-1-N-1 M4LhV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDHRVFKSzVyPUm2Nk45OSCwTR?= NHvUb29USU6JRWK=
HSC-3 NXLl[olxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:0SnZKSzVyPUm2Ok41QCCwTR?= MnrvV2FPT0WU
TYK-nu NUDNZWI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXK2V5RHUUN3ME25PVgvOjVibl2= MoP2V2FPT0WU
KYSE-150 M{TJfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV35VW1NUUN3ME2xMlAxODd4IN88US=> NHfsZ3hUSU6JRWK=
SN12C MlHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rjSGlEPTB;MT6wNFg4PSEQvF2= NYPI[|FNW0GQR1XS
MOLT-13 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWi3VVJLUUN3ME2xMlAyPDJzIN88US=> MVPTRW5ITVJ?
TE-11 NGXHSnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TWUWlEPTB;MT6wOFgyOiEQvF2= NHPFeo9USU6JRWK=
DB NWrY[3h4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LPemlEPTB;MT6wO|I4OyEQvF2= M3TYfnNCVkeHUh?=
CAL-39 NFmzSIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTFwMEe1NlIh|ryP NX7UdFN5W0GQR1XS
A3-KAW M{eyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml65TWM2OD1zLkC4OFA5KM7:TR?= MU\TRW5ITVJ?
CHP-134 NITydZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXCTWM2OD1zLkGxPFA4KM7:TR?= NEHKfY5USU6JRWK=
TGW M4XLTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjBT5RKSzVyPUGuNVI{QTVizszN Mo\RV2FPT0WU
QIMR-WIL MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2W0c2lEPTB;MT6xN|E{PCEQvF2= M{jmUHNCVkeHUh?=
NCI-SNU-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUmzR|RuUUN3ME2xMlE3OzV2IN88US=> NELPc4tUSU6JRWK=
CGTH-W-1 NUXiUWJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnPV4tZUUN3ME2xMlE4OTh4IN88US=> NFXxeJhUSU6JRWK=
MHH-ES-1 M1y0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFwMUe5PFYh|ryP MlXlV2FPT0WU
LB2241-RCC NXzr[3JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7OfVZ4UUN3ME2xMlE5PjJizszN NGS5WVlUSU6JRWK=
ML-2 NGqzcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7uTWM2OD1zLkKwO|M1KM7:TR?= NEDyXnpUSU6JRWK=
COR-L23 MlHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfzTWM2OD1zLkKyPVM{KM7:TR?= MXTTRW5ITVJ?
BFTC-905 M{HrRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK4d5hvUUN3ME2xMlI1OjZ5IN88US=> NWD2c3dIW0GQR1XS
Hs-578-T NVnsfZR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTFwMkW4NVch|ryP NFTrN2tUSU6JRWK=
KG-1 Ml;qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTFwMk[2PFYh|ryP M3XEO3NCVkeHUh?=
HEL Mk\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWC3PYdyUUN3ME2xMlI6OzN6IN88US=> MXHTRW5ITVJ?
A549 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfQZ5lNUUN3ME2xMlI6Ozl7IN88US=> M1vETHNCVkeHUh?=
COLO-741 M37rb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvQXGNJUUN3ME2xMlMzODh7IN88US=> NYLqNpp[W0GQR1XS
PC-3 Moe3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInmPHJKSzVyPUGuN|UzOjFizszN MVzTRW5ITVJ?
HOS NEjLSlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XUWmlEPTB;MT6zOVI6PiEQvF2= Mom2V2FPT0WU
HT-1080 Mnf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnOfoNKSzVyPUGuN|c2OTlizszN MnTtV2FPT0WU
TE-8 MkTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjEW4dKSzVyPUGuOFE4PzRizszN MnvtV2FPT0WU
BHY NHPEfZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PEN2lEPTB;MT60OlkzOyEQvF2= NXvhcZM2W0GQR1XS
BB65-RCC M2jLNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTFwNUC1Nlgh|ryP M2K1NHNCVkeHUh?=
HN MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTFwNUSwO|Eh|ryP MnzFV2FPT0WU
NCI-H441 NYO5bItXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUCw[HFkUUN3ME2xMlU1QTB5IN88US=> NYXVZYR6W0GQR1XS
RPMI-8866 NGC2XHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInU[XVKSzVyPUGuOVg2ODdizszN NFPkenZUSU6JRWK=
CAL-62 M3S1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTFwNkC4OlIh|ryP NH;tU25USU6JRWK=
MG-63 M3Xp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XsOGlEPTB;MT62NVgyOyEQvF2= NFHwc4RUSU6JRWK=
SK-LU-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\UTWM2OD1zLk[yNVUzKM7:TR?= MkDxV2FPT0WU
BCPAP M2O5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFf1eZJKSzVyPUGuOlY1PTdizszN NV7GUGJuW0GQR1XS
22RV1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTFwNke4OFMh|ryP M2nCOnNCVkeHUh?=
T47D NUf6PIJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;5NGdKSzVyPUGuOlgxPjFizszN MX3TRW5ITVJ?
MSTO-211H NX:2cYtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTFwNkm2NFMh|ryP NGe0[YxUSU6JRWK=
DEL NGGwbZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTFwN{CyO|Mh|ryP NG\kc4NUSU6JRWK=
H4 M2niXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT3TWM2OD1zLkezNlEzKM7:TR?= NF3E[ppUSU6JRWK=
CAL-51 NHfzd2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPNfY1NUUN3ME2xMlc1QDV3IN88US=> NXi5Om5vW0GQR1XS
ABC-1 NVHRNpVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\EbIF3UUN3ME2xMlc5PTh{IN88US=> M4q4VnNCVkeHUh?=
MZ2-MEL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW[yS2NzUUN3ME2xMlc6PTR{IN88US=> MWjTRW5ITVJ?
YKG-1 NF:2fWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX75eFV1UUN3ME2xMlgyODZzIN88US=> MULTRW5ITVJ?
KM12 NHnRc2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTFwOEG2NFIh|ryP NYjRV29sW0GQR1XS
L-363 NH31ZWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXIXZVKSzVyPUGuPFc1OTJizszN NHf4RZFUSU6JRWK=
KU812 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXroOI1JUUN3ME2xMlg6Ojh{IN88US=> NHXxdI1USU6JRWK=
LOXIMVI NILGPFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTFwOUGyNlgh|ryP M4XxNnNCVkeHUh?=
G-401 NGKxZ2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHFOnliUUN3ME2xMlkzPDJ6IN88US=> NGLzVHhUSU6JRWK=
SW780 MnHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;pU|hoUUN3ME2xMlk3OjR4IN88US=> M4TycXNCVkeHUh?=
SW872 Mk[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrwU|JKSzVyPUGuPVg{OyEQvF2= NGLPOW5USU6JRWK=
NB7 NXW5R4RMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moq2TWM2OD1zLkm5N|I{KM7:TR?= M3LGW3NCVkeHUh?=
T98G NF:yTVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFP6Xm1KSzVyPUKuNFA3PjZizszN NG\rU5NUSU6JRWK=
SW1710 NEm0TnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLMTWM2OD1{LkC2PVQ2KM7:TR?= NWnSXJB{W0GQR1XS
NCI-H1573 NUXjT|ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJwMEeyPVgh|ryP NVnKTVRGW0GQR1XS
KE-37 M2jqUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\QUmJpUUN3ME2yMlA5QTVzIN88US=> MUPTRW5ITVJ?
786-0 MoPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWeyRYZQUUN3ME2yMlE2PDN7IN88US=> NWnQU2JbW0GQR1XS
SAS M1;GSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTJwMkCzO|Qh|ryP MVHTRW5ITVJ?
CAL-54 NUH1Z2loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PuOGlEPTB;Mj6yNFQyOyEQvF2= NH7NOYtUSU6JRWK=
SF268 NHXFT4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTJwMkOxNlIh|ryP M1PFZXNCVkeHUh?=
SW620 MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoThTWM2OD1{LkK2NVY6KM7:TR?= MV;TRW5ITVJ?
MN-60 NHrEPHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTJwM{GwOkDPxE1? NXnCcXZtW0GQR1XS
EFO-27 M2ToOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[3fmlEPTB;Mj6zNlA2QCEQvF2= M2DvZXNCVkeHUh?=
NCI-H747 NXrqbIJDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDnPFBXUUN3ME2yMlMzOTl7IN88US=> NVjpbHpWW0GQR1XS
HCC2218 NH2z[45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\ETWM2OD1{LkO1N|c1KM7:TR?= NGPJUJRUSU6JRWK=
MIA-PaCa-2 MmPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDBTWM2OD1{LkO2OFM4KM7:TR?= MnjCV2FPT0WU
SJSA-1 NHL1RZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzmSGtKSzVyPUKuN|c4QTZizszN M3PQbHNCVkeHUh?=
RKO M2XTZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn23TWM2OD1{LkO4OFk3KM7:TR?= MoHhV2FPT0WU
NB6 NF6xN5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4L1UWlEPTB;Mj60NFM4PCEQvF2= M1;WNXNCVkeHUh?=
ES4 M2Hhfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTJwNEW0NlIh|ryP NFrnR|lUSU6JRWK=
EGI-1 NFrLcHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTjU2JKSzVyPUKuOFY5QDNizszN Mlf6V2FPT0WU
CTV-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonXTWM2OD1{LkWyO|c{KM7:TR?= NGPpfFRUSU6JRWK=
NCI-H1355 NYLjTZV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlK3TWM2OD1{LkW1PVUyKM7:TR?= NETGTplUSU6JRWK=
GT3TKB Mnv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLONXVKSzVyPUKuOVkyQTlizszN M4T6Z3NCVkeHUh?=
SK-HEP-1 Ml7DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HxT2lEPTB;Mj61PVI3PiEQvF2= NHzmbZNUSU6JRWK=
GAMG NW\FVpROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLMToVKSzVyPUKuOVk{QTRizszN M3jDdnNCVkeHUh?=
SK-MES-1 MoPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3VTWM2OD1{Lk[xPFA{KM7:TR?= NFnIWlVUSU6JRWK=
RO82-W-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJwNkKwOVch|ryP M{CzdXNCVkeHUh?=
ECC10 MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn2TWM2OD1{LkewNlA3KM7:TR?= M3rOPXNCVkeHUh?=
MCF7 MnLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2HXU2lEPTB;Mj63NVQ3PCEQvF2= NITXOJpUSU6JRWK=
D-283MED M1fzVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTDTWM2OD1{LkeyOFMh|ryP Mn\GV2FPT0WU
RPMI-7951 M1LMeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTJwN{W2PVQh|ryP NEO2PZVUSU6JRWK=
Ramos-2G6-4C10 MlzwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVntdYZJUUN3ME2yMlc4ODl7IN88US=> NGS2cItUSU6JRWK=
KGN MlGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\FTWM2OD1{LkixPFg1KM7:TR?= NX\1PGZMW0GQR1XS
NUGC-3 MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJwOEK1NFUh|ryP NYTKZW9EW0GQR1XS
NCI-H292 MlrIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3GxSGlEPTB;Mj64OVA2OyEQvF2= MXTTRW5ITVJ?
Becker MoTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jh[mlEPTB;Mj65OVg{OiEQvF2= MXrTRW5ITVJ?
NCI-H1299 NWrDZnpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPkWmpKSzVyPUOuNFUzPjNizszN M1;TPHNCVkeHUh?=
ETK-1 NV7nNVBET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\Be2d6UUN3ME2zMlA2PDNizszN MmX3V2FPT0WU
TK10 MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvoeIFQUUN3ME2zMlIxOTZ3IN88US=> NFvXVmJUSU6JRWK=
VMRC-RCZ M{PrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTNwM{[0PFgh|ryP NHfubXVUSU6JRWK=
YH-13 NHjEWFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\xTWM2OD1|LkS0NFc6KM7:TR?= MXLTRW5ITVJ?
DU-145 NYC2T|hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P1[mlEPTB;Mz60OlI3QSEQvF2= M3\lbHNCVkeHUh?=
SW1088 NHezeolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrnTWM2OD1|LkS3OFch|ryP MVrTRW5ITVJ?
HOP-92 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTNwNUCzOFIh|ryP NFnVSohUSU6JRWK=
KP-N-YS NWfFTXd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[4bGlEPTB;Mz62NlE{QSEQvF2= NF[zOmJUSU6JRWK=
NCI-H460 M3:2d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTNwNk[3N{DPxE1? NXj3S2Z5W0GQR1XS
U-2-OS M4rZcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTNwN{K1N|Uh|ryP NIGzZ3lUSU6JRWK=
A101D MlLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV:x[25OUUN3ME2zMlc3QTN4IN88US=> MULTRW5ITVJ?
MDA-MB-231 M{PldWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4W4c2lEPTB;Mz64NVk2OSEQvF2= M1ThZ3NCVkeHUh?=
IST-MES1 NWPmWJNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPFbGlKSzVyPUOuPFMzKM7:TR?= M1nmPXNCVkeHUh?=
COR-L105 MnLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XSOmlEPTB;ND6wNVgh|ryP M1XhVnNCVkeHUh?=
NCI-H1437 M1HJTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEOwTmxKSzVyPUSuNFI{ODJizszN NFnTWFhUSU6JRWK=
CAL-85-1 NHH1fo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHET4J4UUN3ME20MlAzPDZzIN88US=> M{XCWXNCVkeHUh?=
MZ1-PC M4q1e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTkTWM2OD12LkG4OVU3KM7:TR?= MVTTRW5ITVJ?
VM-CUB-1 NFXhZVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUC4XFJ{UUN3ME20MlMyOjh2IN88US=> MXjTRW5ITVJ?
CHL-1 NGi5em1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHlXnRnUUN3ME20MlMzOTZ7IN88US=> NYHMcJE4W0GQR1XS
MDA-MB-361 NEjLfZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnvSTWM2OD12LkOzNVU{KM7:TR?= M3nXbHNCVkeHUh?=
NCI-H661 NF;HXGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7ENVl3UUN3ME20MlUxODl{IN88US=> NE\pT|NUSU6JRWK=
EW-11 NGK1TWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfkUJRKSzVyPUSuOVIzOzFizszN MmW0V2FPT0WU
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HLE NYrnTY9kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{H1WmlEPTB;MUSuN|g2OiEQvF2= NX7sc4xTW0GQR1XS
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LB996-RCC M3LXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MortTWM2OD1{MD63NVY5KM7:TR?= NGTXXYVUSU6JRWK=
KYSE-70 M1Xafmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;0NmlEPTB;MkCuPFA2QSEQvF2= Mk\pV2FPT0WU
CAL-72 MojnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HRemlEPTB;MkCuPVE2KM7:TR?= NVraSlR1W0GQR1XS
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Calu-6 NGXaUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfITWM2OD1{NT61NFcyKM7:TR?= M{L6OnNCVkeHUh?=
SJRH30 MlLVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK4TWM2OD1{NT62OFk3KM7:TR?= MmXBV2FPT0WU
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GP5d M{nHOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfySWpDUUN3ME2yOk41PDlzIN88US=> M{HiOXNCVkeHUh?=
NCI-H2291 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DLWWlEPTB;Mk[uOlU1OSEQvF2= MkK0V2FPT0WU
BALL-1 MlTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXzd5ZKSzVyPUK2Mlk{QTdizszN M3jrRnNCVkeHUh?=
HCC1954 NETpcXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3WTWM2OD1{Nj65PFA5KM7:TR?= NYTzUolNW0GQR1XS
NCI-H2452 NXn4Oo5GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXVXoo3UUN3ME2yO{41OTZ|IN88US=> MofFV2FPT0WU
LU-99A NELCeYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTJ5LkW1PFIh|ryP NGDjfHhUSU6JRWK=
NTERA-S-cl-D1 NWrIRmp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrYPXFVUUN3ME2yO{44Ojl7IN88US=> NYH4R3FJW0GQR1XS
PANC-10-05 M3;aS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnL5TWM2OD1{Nz63O|c2KM7:TR?= NVvtUWJGW0GQR1XS
NCI-H2405 MmTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPWT4pKSzVyPUK3Mlk{QDdizszN M4rLVXNCVkeHUh?=
MDA-MB-415 M4q5S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjYTWM2OD1{OD60NVM4KM7:TR?= NIPlSZVUSU6JRWK=
NCI-H2342 NIjHVYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX3Vm9KSzVyPUK4MlUzQDFizszN NY\BTIFDW0GQR1XS
TGBC24TKB MoW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTJ6LkexNVch|ryP M4nOUXNCVkeHUh?=
LU-134-A NUHKfIVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7MRm0xUUN3ME2yPE46OjZzIN88US=> NX;IW2NpW0GQR1XS
SCC-4 MkOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTNzLkC0PVQh|ryP MYTTRW5ITVJ?
Saos-2 NU\kZlVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTNzLkmzNFYh|ryP M2nMPHNCVkeHUh?=
RERF-LC-MS M4HpfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTN{LkiyN|Eh|ryP NEHDcm1USU6JRWK=
M14 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvRe2d{UUN3ME2zNk46PzZ2IN88US=> Ml3yV2FPT0WU
HPAF-II M3PCOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHf1ZWlKSzVyPUOzMlUxOTFizszN NYTjT3RmW0GQR1XS
NCI-H1755 NUHwWIFIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PtV2lEPTB;M{SuN|MxPSEQvF2= NFTMVndUSU6JRWK=
D-392MG NWXiWVR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXZcWhzUUN3ME2zOU45Pjd2IN88US=> NGWx[YNUSU6JRWK=
A704 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXjWnpKSzVyPUO2MlA1OjdizszN MnjXV2FPT0WU
CP50-MEL-B MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XPfWlEPTB;M{[uNVkyOSEQvF2= NHn0c|JUSU6JRWK=
EW-18 M3rjV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PiZWlEPTB;M{[uOFUzKM7:TR?= MlnOV2FPT0WU
WM-115 MojYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXnbmNxUUN3ME2zOk45ODl7IN88US=> NWHqO3JOW0GQR1XS
LU-65 M2LHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoexTWM2OD1|Nz6xOFE4KM7:TR?= MWjTRW5ITVJ?
NCI-H1563 MoHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTN5LkK0PFQh|ryP MkDmV2FPT0WU
DBTRG-05MG Ml;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\rXWlEPTB;M{iuNFY6OSEQvF2= MWjTRW5ITVJ?
NCI-H630 NWfS[m17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTN6LkS3NVQh|ryP MYjTRW5ITVJ?
NCI-H1155 NFH1eFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHkTWM2OD1|OT6yOFIh|ryP MUHTRW5ITVJ?
OVACR-3 NGDVT|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnEOXpKSzVyPUO5MlkyQTVizszN MYXTRW5ITVJ?
OAW-42 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorhTWM2OD12MD60NlU5KM7:TR?= M1nG[HNCVkeHUh?=
JVM-2 MmDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\Dc2lEPTB;NEGuNlQyPSEQvF2= MUTTRW5ITVJ?
C3A M2m2Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[3TWM2OD12MT6zOFQ4KM7:TR?= M2T5RXNCVkeHUh?=
HT55 M1\ucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTR{LkK4OFEh|ryP M{jOPXNCVkeHUh?=
OVCAR-4 Mk[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTDW2RIUUN3ME20Nk4zQTd2IN88US=> MUTTRW5ITVJ?
MEG-01 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPQZ4pKSzVyPUSyMlQ3OTZizszN M37WXHNCVkeHUh?=
NCI-H82 M2PmZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXudHVKSzVyPUSzMlk5QTJizszN Mn\WV2FPT0WU
JEG-3 M2HWeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rFdWlEPTB;NESuPVQ4KM7:TR?= M2izfHNCVkeHUh?=
BPH-1 NF[2UGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH1OIpKUUN3ME20Ok4{QTl6IN88US=> M{X1enNCVkeHUh?=
MPP-89 NXi0eYRLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDPTYlKSzVyPUS3MlI5QThizszN MmXPV2FPT0WU
ALL-PO MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2P6NGlEPTB;NEeuOFE5QCEQvF2= NE\FeHBUSU6JRWK=
HT MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TwR2lEPTB;NEeuOFkzKM7:TR?= MXLTRW5ITVJ?
NCI-H2347 NYXCXINPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfFOFBKSzVyPUS4MlA4OTVizszN NVOzdFZkW0GQR1XS
A2780 MlruS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTR7LkSyNlgh|ryP MYTTRW5ITVJ?
KARPAS-299 NU\CTJhYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITjRoRKSzVyPUS5MlUyOTlizszN NGHWZndUSU6JRWK=
NCI-H1651 MlXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\HRXNjUUN3ME20PU45QDJzIN88US=> NXzYfGw5W0GQR1XS

... Click to View More Cell Line Experimental Data

体内研究 150 mg/kg PD 0332991处理 MDA-MB-435移植瘤完全抑制肿瘤。在多种人类肿瘤移植瘤中,PD 0332991也显示广谱抗癌活性,通过除去血管中p-Rb和增殖Marker Ki-67,且调节基因使其处于E2F转录水平控制。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

Cdk实验:

PD0332991溶解在DMSO中。在96孔板上进行CDK 实验。通过杆状病毒感染,所有的CDK-cyclin 激酶复合体 在昆虫细胞中表达。实验底物为与GST融合的一段pRb。每孔体积为0.1 ml,包含:终浓度为20 mm Tris-HCl(pH 为7.4), 50 mmNaCl, 1 mm二硫苏糖醇, 10 mmMgCl2, 25 μm ATP (用于CDK4-cyclin D1, CDK6-cyclin D2,和CDK6-cyclin D3)或12 μm ATP (用于CDK2-cyclin E, CDK2-cyclin A, 和CDC2-cyclin B),0.25 μCi [γ-32P]ATP, 20 ng 酶, 1 μg GST·RB-Cterm, 及PD 0332991 (0.001-0.1μM)。除了[γ-32P]ATP的所有混合物加到孔中,放在搅拌器上搅拌2分钟。加入 [γ-32P]ATP开始反应, 在25 oC下温育15分钟。加入0.1 ml 20% 三氯乙酸终止反应, 在4 oC维持至少1小时,使底物沉淀。用0.2 ml 10%三氯乙酸冲洗5次,用β-计数器板测定掺入的放射性。
细胞实验:

[1]

+ 展开
  • Cell lines: MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,和K562细胞
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24小时
  • Method:

    肿瘤细胞包括MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,及K562按每孔2×104个细胞接种在96孔板上,温育过夜。加入PD 0332991 (0.01-1 μM) ,37oC温育24小时。每孔加入[14C]胸甘(0.1 μCi) ,进行同位素示踪,持续72小时。用β-计数器板测定掺入的放射性。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 携带晚期人类肿瘤移植瘤,包括结肠-205, MDA-MB-435 乳腺癌, SF-295 恶性胶质瘤, ZR-75-1 乳腺癌, PC-3 前列腺癌, H125 肺癌, SW-620结肠癌, H23肺癌,及MDA-MB-468 乳腺癌 (Rb 阴性)的SCID鼠
  • Formulation: 溶解在乳酸钠buffer(50 mM, pH 4.0)中
  • Dosages: 0-150 mg/kg
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
Saline
6 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 483.99
化学式

C24H29N7O2.HCl

CAS号 827022-32-2
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03007979 Not yet recruiting Breast Cancer|Breast Carcinoma|Cancer of Breast|Malignant Tumor of Breast Washington University School of Medicine February 28, 2017 Phase 2
NCT02907918 Not yet recruiting Breast Cancer|Cancer of Breast|Breast Carcinoma Washington University School of Medicine|Pfizer February 28, 2017 Phase 2
NCT01209598 Completed Sarcoma|Liposarcoma Memorial Sloan Kettering Cancer Center|Pfizer September 23, 2010 Phase 2
NCT03054363 Not yet recruiting Breast Cancer University of Colorado, Denver March 2017 Phase 1|Phase 2
NCT03024489 Not yet recruiting Head and Neck Cancer|Locally Advanced|Unresectable Mahidol University February 2017 Phase 1|Phase 2
NCT02947685 Not yet recruiting HER-2 Positive Breast Cancer|Estrogen Receptor Positive Breast Cancer Alliance Foundation Trials, LLC.|Pfizer|German Breast Group (GBG)|Fondazione Michelangelo|PrECOG, LLC.|The Australia and New Zealand Breast Cancer Trials Group (ANZBCTG)|Alliance Foundation Trials Biorepository - Washington State University|Alliance Foundation Trials Central Imaging Core Lab - Ohio State University|Mastering Breast Cancer Initiative, LLC|Mayo Clinic Statistics and Data Center|INC Research|SOLTI Breast Cancer Research Group February 2017 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID