Palbociclib (PD-0332991) HCl

Pfizer辉瑞授权 目录号:S1116

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。

规格 价格 库存 购买数量  
RMB 902.49 现货
RMB 1406.17 现货
RMB 4670.26 现货
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客户使用该产品的8个实验数据:

  • PD-0332991 causes inhibition of proliferation of EAC cells in a dose-dependent manner. Western blots showing the phosphorylation status of pRB at Ser780 and Ser795 after incubation with 125 nmol/L PD-0332991 for 24 and 72 hours. Reduction in cyclin A expression and the expression of RB2 (p130) tumor suppressor 72 hours after PD-0332991 treatment are shown (bottom). Total pRB (RB1) and actin are loading controls and T293 cell lysate (293) is a positive control for total pRB and phospho-pRB (Ph-RB). E, anchorage-independent growth of the 3 cell lines in the presence or absence (Cnt) of 125 nmol/L PD-0332991 for 3 weeks.

    Clin Cancer Res 2011 17(13), 4513-22. Palbociclib (PD-0332991) HCl purchased from Selleck.

    b, c MelJuso cells were treated for 12–48 h with 1 µM Selumetinib or 5 µM Palbociclib and the cells were fixed, stained with propidium iodide and cell cycle distribution was determined by flow cytometry (b) and whole cell extracts were fractionated by SDS-PAGE, transferred onto PVDF membrane and immuno-blotted with the indicated antibodies (c). Data is from a single experiment representative of three separate experiments with similar results. The data in (b) are mean ± S.D. from a single experiment with three replicate dishes of cell per data point; similar results were obtained in two additional experiments

    Cell Mol Life Sci, 2016, 73(4):883-900. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • (A) Percentage of DN3a cells in S-phase (as gated on DAPI profile) from control (Zfp36l1/2fl/fl) and Zfp36l1/2fl/fl; CD2Cre (DCKO) mice, after 1 d of treatment with vector or palbociclib (drug).

    J Immunol, 2016, 197(7):2673-85. Palbociclib (PD-0332991) HCl purchased from Selleck.

     

    Patient tumor cell sensitivity to combinatorial treatment with histone deacetylase (HDAC)/cyclin-dependent kinase (CDK) inhibitors in 3-D culture. The effect of each drug or drug combination was assessed by fluorescent dye to identify live (green) and dead cells (red). Cells from breast reduction patients were used as non-cancer control in the assay.

    Pharmacogenomics J 2013 13(1), 94-104. Palbociclib (PD-0332991) HCl purchased from Selleck.

  •  

    Cdk4 is upregulated in ARMS and mMSCs transfected with PAX7-FKHR fusion gene (MP7F), and can be specifi cally inhibited. D: IF results showing overexpression of cdk4 in MP7F cells compared to parental mMSCs and reduced expression of cdk4 after treatment of MP7F cells with the cdk4 inhibitor, PD-0332991. E: IF results showing MyoD1 expression in parental mMSCs cells, and MP7F cells untreated and after treatment with the cdk4 inhibitor, PD-0332991.

    Clin Transl Oncol 2012 14(3), 197-206 . Palbociclib (PD-0332991) HCl purchased from Selleck.

    WM3734 melanoma cells were treated by PD-0332991 for 36 hours; melanoma cells treated by Doxorubicin (DXR)  at 0.5 μM is included as a control.

     

     

    Dr. Gao Zhang of University of Pennsylvania. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • Serum-deprived T98G glioma cells are restimulated with serum(FBS) with or without 1 μΜ PD-0332991.

     

     

    Dr. Sabine Paternot and Dr Pierre Roger of IRIBHM, ULB, Brussels. Palbociclib (PD-0332991) HCl purchased from Selleck.

    P16INK4A knockdown in INK4A/ARF-wt human glioma cell LN319 potentiates PDGF-Apromoted anchorage-dependent growth in vitro. Soft agar growth of Ink4a/Arf-deficient mAst and LN444 cells treated with PD0332991. (A) IB analysis. (B) Quantification of soft agar assays. β-actin was used as a loading control in all IB experiments. Data are presented as mean ± s.d. and representative of two independent experiments. **, P < 0.01; ***, P < 0.001

    Dr. Kun-Wei Liu from University of Pittsburgh. Palbociclib (PD-0332991) HCl purchased from Selleck.

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。
特性 PD-0332991作为有应用前景的工具测定CDK激酶是否具有明显的治疗价值。
靶点
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外研究

PD 0332991 对其他蛋白激酶包括EGFR, FGFR, PGFR, IR等没有抑制效果。 PD 0332991作用于Cdk4时是非ATP竞争性抑制剂。PD 0332991抑制MDA-MB-435乳腺癌细胞,IC50为66 nM,是由于Rb 在Ser780的磷酸化作用下降。PD 0332991抑制胸苷合并到Rb阳性的人类乳腺癌,结肠癌 肺癌,及白血病的DNA中,IC50值为4 nM到0.17 μM。PD 0332991作用于Rb阴性细胞没有抑制效果。PD 0332991作用于MDA-MB-453乳腺癌细胞和结肠-205细胞使细胞积累在G1期。[1]PD 0332991也有效作用于骨髓瘤5T33MM细胞,使细胞对Bortezomib敏感。[2]PD 0332991抑制luminalER-阳性和HER2-增强的乳腺癌细胞系,包括MDA-MB-175 ZR-75-30 CAMA-1 MDA-MB-134 HCC-202 UACC-893 等等。在这些细胞系中,PD 0332991增强Tamoxifen和Trastuzumab 的活性。在MCF7抗Tamoxifen细胞中,PD 0332991也增强tamoxifen 的敏感性。[3] 最新研究显示PD 0332991可以抑制恶性横纹肌样肿瘤(MRT)细胞系包括MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS,且MRT细胞系对PD 0332991敏感性和p16表达呈负相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 M3fZPGtqdmG|ZTDBd5NigQ>? NGTmRWkzPCCq MlvYTY5pcWKrdHnvckBw\iCFRFu0JIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gVoIheGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCwNkDPxE1? NHvqNFUzPDZ2MUGwNy=>
COLO205 MmjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPjNYo5PzJiaB?= NYPiSWVySW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX7jc5Jxd3KjdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlvfG9iRF7BJJdqfGhiSVO1NEBw\iByLkCzOkDPxE1? NIr4d2IzPDZ2MUGwNy=>
U937 NE\GOpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn22O|IhcA>? NH3rNHlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMUSg{txO M1vKb|I1PjRzMUCz
MOLM13 NX7oS5Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkizO|IhcA>? MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2RTF2xN{Bk\WyuczDoZZJjd3KrbnegSmxVOyCLVFSgcZV1[W62IHHzd4V{e2WmIHHzJIlv[2:{cH;yZZRqd25ib3[gX|NJZXSqeX3p[Ilv\SCrboTvJGRPSSC5aYToJGlEPTBib3[gNE4xQTZizszN MVWyOFY1OTFyMx?=
MOLM13 MkTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUW3NkBp MoHWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDzc5Ji\mWwaXKtdoV{cXO2YX70JIh2dWGwIF3PUG0yOyClZXzsd{Bie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEm2JO69VQ>? NV6yVpZvOjR4NEGxNFM>
MDA-MB-435 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUeyOEBp MXfJR|UxRTBwMU[g{txO NYLkOXZrOTV6MEG4N|E>
K562 MnTxR5l1d3SxeHnjJGF{e2G7 NHHybWY6PiCq NVq5TIZOTE2VTx?= M3O2VWlEPTB;MjFOwG0> MV:yOFQyPzV4Nh?=
DU145 MWrDfZRwfG:6aXOgRZN{[Xl? MmXIPVYhcA>? NXzqVYNrTE2VTx?= MWPJR|UxRTdwNTFOwG0> MXOyOFQyPzV4Nh?=
MDA-MB-231 NEnKR4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPIclNOOSEQvF2= MV2yOEBp M3vkOmROW09? NUTuPYFXS2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdzIIDoZZNm M1rkXlI1PDF5NU[2
MCF7 M1OwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnWyNUDPxE1? MlXFNlQhcA>? MWDEUXNQ MXrD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|EheGijc3W= NID3[XYzPDRzN{W2Oi=>
MCF7 NV7Gb3V1U2mwYYPlJGF{e2G7 MWq1JO69VQ>? NXv5bpg{OjRiaB?= MWTEUXNQ MXjJcohq[mm2aX;uJI9nKHKnY3;tZolv[W62IFPET|Qw[3mlbHnuSFEh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBz\XSrbn;icIF{fG:vYTDwbI9{eGixconsZZRqd25iYYSgV4VzPzhy MornNlQ1OTd3Nk[=
MDA-MB-231 M2i3bmtqdmG|ZTDBd5NigQ>? MYG1JO69VQ>? M3PRRlI1KGh? NXOyNJVSTE2VTx?= MlLzTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDDSGs1N2O7Y3zpcmQyKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhemW2aX7vZoxie3SxbXGgdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejd6MB?= NF3OUGYzPDRzN{W2Oi=>
MDA-MB-231 MVzGeY5kfGmxbjDBd5NigQ>? MkC1NU0yOCEQvF2= NV;2WHVHOjRiaB?= Mnu4SG1UVw>? NUXu[5dO\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyCSQWLQJINt\WG4YXfl MUGyOFQyPzV4Nh?=
MCF7 NHHY[G9HfW6ldHnvckBCe3OjeR?= NETwbYQyNTFyIN88US=> Mo[2NlQhcA>? MoKxSG1UVw>? Mlm2[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BRSVKSIHPs[YF3[Wen NV;C[nNFOjR2MUe1OlY>
MDA-MB-231 NHLKXGZHfW6ldHnvckBCe3OjeR?= MlfhNE42NTFizszN MmfmOFghcA>? NFPiWpdFVVOR NUHJS5FucGG|IH7vJGNmdGxiY4njcIUh[XK{ZYP0JIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEB{fWJvR{GgdIhie2V? NIDDRpUzPDRzN{W2Oi=>
MCF7 MlK4SpVv[3Srb36gRZN{[Xl? MWSwMlUuOSEQvF2= MVi0PEBp MWHEUXNQ NGXBR29p[XNibn:gR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMTDwbIF{\Q>? NEeyeXYzPDRzN{W2Oi=>
697 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ixNWlEPTB;MUS4MlM5KG6P MoTKV2FPT0WU
P12-ICHIKAWA MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXMTWM2OD17Nj6wOEBvVQ>? MmXTV2FPT0WU
NB69 M4P0TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvOTWM2OD1zNkGuPEBvVQ>? MWnTRW5ITVJ?
EoL-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPTOGdKSzVyPUG4O{4zPiCwTR?= NVPKOINmW0GQR1XS
BHT-101 Ml;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHe2OFJKSzVyPUG5PE4zPSCwTR?= MUHTRW5ITVJ?
SK-NEP-1 NXjZO|huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJ{MD6wNkBvVQ>? MUXTRW5ITVJ?
MHH-NB-11 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\6VYJKSzVyPUKyNE4yQSCwTR?= NHLzWpZUSU6JRWK=
AsPC-1 NGLT[3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTJ3Mj61N{BvVQ>? MlrFV2FPT0WU
ES1 M3;4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG3W|JKSzVyPUK1Ok4zPSCwTR?= MYfTRW5ITVJ?
LAMA-84 NHrmNmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnK[5Q1UUN3ME2yOVgvOTlibl2= M3Ly[XNCVkeHUh?=
MOLT-16 MkWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrxeI5KSzVyPUK1PE41QSCwTR?= MoTvV2FPT0WU
ES7 NF3sWJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTJ5Mz6wPUBvVQ>? M4fwfHNCVkeHUh?=
KY821 MnfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEj4eoRKSzVyPUOxOE4yKG6P MVnTRW5ITVJ?
RT-112 M{DUemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTN{MT6wOUBvVQ>? M2S4bnNCVkeHUh?=
HL-60 Ml\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XYTmlEPTB;M{SwMlY3KG6P NIW0RmVUSU6JRWK=
MOLT-4 NXLT[lU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrsTWM2OD1|NEWuNVMhdk1? MoKwV2FPT0WU
KARPAS-45 M3e1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnw[VFJUUN3ME2zO|YvOTZibl2= M4rjXXNCVkeHUh?=
SK-N-AS NUT0Z2QyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDLS3lKSzVyPUO4O{45OyCwTR?= NHXaTWpUSU6JRWK=
CTB-1 NUm1cY9yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTRyNT6wNkBvVQ>? NWTscYRDW0GQR1XS
NKM-1 NI\kRmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXYco5IUUN3ME20NVEvQDlibl2= MX3TRW5ITVJ?
HTC-C3 NX3Nb3h6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTR|Mj65OUBvVQ>? MnXsV2FPT0WU
BE-13 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTR2ND6yO{BvVQ>? NUXmSVFxW0GQR1XS
KOSC-2 M{\hTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXmTWM2OD12Nk[uPUBvVQ>? MYDTRW5ITVJ?
NB14 NYLrfHk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLOWnpKSzVyPUS4N{42QCCwTR?= NXnMNpRSW0GQR1XS
CAL-27 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXoUpREUUN3ME20PVQvPTlibl2= MmHCV2FPT0WU
H9 NFK0OnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3PfHdKUUN3ME20PVUvPDNibl2= MXzTRW5ITVJ?
RS4-11 NVz0ZYJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljCTWM2OD13MESuO|Mhdk1? MmS1V2FPT0WU
PA-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXlcmJKSzVyPUWwPU45PiCwTR?= MY\TRW5ITVJ?
MV-4-11 M3\2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i2S2lEPTB;NUGzMlg2KG6P NX7BZ2NVW0GQR1XS
OS-RC-2 NXHibmVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDOPHNtUUN3ME21NlEvPjJibl2= Mn72V2FPT0WU
RPMI-8226 NHPEdndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LmfWlEPTB;NUK2Mlg3KG6P MkX4V2FPT0WU
HGC-27 NFXMdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX2wcYRtUUN3ME21OlQvQTlibl2= M2LqOXNCVkeHUh?=
CHP-212 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTtXpVKSzVyPUW5N{42QSCwTR?= MWDTRW5ITVJ?
NB10 M2jiUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTV7OT6xPEBvVQ>? Mmj0V2FPT0WU
HH MmDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mke3TWM2OD13OUmuOFMhdk1? M1zR[3NCVkeHUh?=
EW-16 NHm1O2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fHNmlEPTB;NkCzMlUzKG6P M{LSd3NCVkeHUh?=
ES8 NWrQWoJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTZyNT6yNUBvVQ>? NIXGSFNUSU6JRWK=
HAL-01 NWjXXHdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTZyNT62O{BvVQ>? M4HsenNCVkeHUh?=
A204 NHjnNnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[zd3R6UUN3ME22N|MvQTFibl2= NFPRRlNUSU6JRWK=
MHH-PREB-1 NFHsN5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvVTXFKSzVyPU[zOk46QSCwTR?= Mn;XV2FPT0WU
EM-2 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnNXVlKSzVyPU[1NE43PCCwTR?= MlLZV2FPT0WU
BV-173 NIH6[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vtNGlEPTB;NkWyMlQ5KG6P MUHTRW5ITVJ?
ONS-76 NHvHOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Dxb2lEPTB;Nke3MlgzKG6P MUHTRW5ITVJ?
KM-H2 MkTRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPwTWM2OD14OUWuOVQhdk1? NH7SbYxUSU6JRWK=
D-263MG Ml3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTdzNz6xNkBvVQ>? NXrzV4U{W0GQR1XS
ES3 NIfkPWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P5RmlEPTB;N{K4Mlk{KG6P MkHkV2FPT0WU
VA-ES-BJ MoPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjxdYtKSzVyPUezNk4zPyCwTR?= MmC2V2FPT0WU
NBsusSR MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLkdJZKSzVyPUe0Nk46QSCwTR?= NHHN[JZUSU6JRWK=
NCI-H520 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfXNpRUUUN3ME23OFYvPTJibl2= MVLTRW5ITVJ?
ES5 NUf0SFFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTGUXpTUUN3ME23OVIvQCCwTR?= M4PXTXNCVkeHUh?=
T-24 NG\JVpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37pWWlEPTB;N{e4MlcyKG6P M3jwR3NCVkeHUh?=
SW962 M4fzdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRThyOD62N{BvVQ>? MX\TRW5ITVJ?
EW-3 NHHpRpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vpdWlEPTB;OEC4Mlc3KG6P NXmxWJc2W0GQR1XS
RXF393 NYDT[5pjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjGXW9qUUN3ME24NVIvPzlibl2= Mn:4V2FPT0WU
U251 MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLqV3FKSzVyPUixN{45QCCwTR?= MXfTRW5ITVJ?
CAMA-1 NVPTOZlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVOxXnE5UUN3ME24N|MvQTRibl2= M2XLUHNCVkeHUh?=
JVM-3 NVLmVpY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4Ti[mlEPTB;OEWxMlc5KG6P MXvTRW5ITVJ?
COLO-800 NHrXSZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXkW2l7UUN3ME24PVcvPzhibl2= MXfTRW5ITVJ?
OVCAR-5 MkizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33XOmlEPTB;OUCwMlEhdk1? M3vqTHNCVkeHUh?=
LB1047-RCC M3fkZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfXTWM2OD17MkeuOVYhdk1? MVHTRW5ITVJ?
SW954 M2HiZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3sRW9KSzVyPUmyPU41OSCwTR?= NUe5ZmZvW0GQR1XS
J-RT3-T3-5 MkG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\JOIZ6UUN3ME25N|YvODZibl2= MYHTRW5ITVJ?
Mewo MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3STWM2OD17M{[uOkBvVQ>? MnjqV2FPT0WU
NCI-H1770 NXT2cJJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjCWVdDUUN3ME25OFAvPTVibl2= NHjXO41USU6JRWK=
HO-1-N-1 Mo\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nwNmlEPTB;OU[yMlgyKG6P MVzTRW5ITVJ?
HSC-3 M1nKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPwTWM2OD17Nk[uOFghdk1? MX;TRW5ITVJ?
TYK-nu MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULucm5{UUN3ME25PVgvOjVibl2= NV3mZlhbW0GQR1XS
KYSE-150 M2r6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\uTWM2OD1zLkCwNFc3KM7:TR?= MkjZV2FPT0WU
SN12C NInxdnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzLNJRZUUN3ME2xMlAxQDd3IN88US=> NELoZZRUSU6JRWK=
MOLT-13 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzGSm5oUUN3ME2xMlAyPDJzIN88US=> M3fPcHNCVkeHUh?=
TE-11 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTFwMES4NVIh|ryP M{[0c3NCVkeHUh?=
DB NVHtb5BkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jkVmlEPTB;MT6wO|I4OyEQvF2= M1Hkb3NCVkeHUh?=
CAL-39 NVrFWJM3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTFwMEe1NlIh|ryP NInrb2lUSU6JRWK=
A3-KAW NXL0dZRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrw[XRKSzVyPUGuNFg1ODhizszN M3LRdXNCVkeHUh?=
CHP-134 M2DHc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTFwMUG4NFch|ryP NYHLS41ZW0GQR1XS
TGW MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGiyWGpKSzVyPUGuNVI{QTVizszN MVnTRW5ITVJ?
QIMR-WIL Ml3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTVfWc{UUN3ME2xMlE{OTN2IN88US=> MYTTRW5ITVJ?
NCI-SNU-1 NEWzeXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[wcoptUUN3ME2xMlE3OzV2IN88US=> M4XwfXNCVkeHUh?=
CGTH-W-1 NG\rNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHW0OYFKSzVyPUGuNVcyQDZizszN MUHTRW5ITVJ?
MHH-ES-1 MlvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fSS2lEPTB;MT6xO|k5PiEQvF2= NWLJRWZGW0GQR1XS
LB2241-RCC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHNTWM2OD1zLkG4OlIh|ryP NEPnPJhUSU6JRWK=
ML-2 NITnSHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLYUmk4UUN3ME2xMlIxPzN2IN88US=> M3HDdnNCVkeHUh?=
COR-L23 M3q5Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7NTWM2OD1zLkKyPVM{KM7:TR?= MkTZV2FPT0WU
BFTC-905 NHPNN4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7OTWM2OD1zLkK0NlY4KM7:TR?= NU\GdFJZW0GQR1XS
Hs-578-T NEL4PGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T5fGlEPTB;MT6yOVgyPyEQvF2= NWDyU5JRW0GQR1XS
KG-1 M{f0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWP3THVvUUN3ME2xMlI3Pjh4IN88US=> NUDWN3c4W0GQR1XS
HEL MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPzXlhKSzVyPUGuNlk{OzhizszN M1\u[nNCVkeHUh?=
A549 MnLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T2e2lEPTB;MT6yPVM6QSEQvF2= MlvrV2FPT0WU
COLO-741 NWjRXYRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHtTWM2OD1zLkOyNFg6KM7:TR?= NUPzVHFHW0GQR1XS
PC-3 NHTKdIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIKzTohKSzVyPUGuN|UzOjFizszN M4jYXHNCVkeHUh?=
HOS M4fJOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTFwM{WyPVYh|ryP M1uyb3NCVkeHUh?=
HT-1080 M{nONGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYOwN25DUUN3ME2xMlM4PTF7IN88US=> MnrUV2FPT0WU
TE-8 Mn[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjzZWpFUUN3ME2xMlQyPzd2IN88US=> NWLybJh2W0GQR1XS
BHY MlrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zSZWlEPTB;MT60OlkzOyEQvF2= MkOxV2FPT0WU
BB65-RCC MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnqwTWM2OD1zLkWwOVI5KM7:TR?= Mkn2V2FPT0WU
HN MnLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPQTWM2OD1zLkW0NFcyKM7:TR?= NUjNWIVbW0GQR1XS
NCI-H441 NEXkSY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Lw[mlEPTB;MT61OFkxPyEQvF2= NYOy[4VMW0GQR1XS
RPMI-8866 M{HmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnX5TWM2OD1zLkW4OVA4KM7:TR?= NWnhclg4W0GQR1XS
CAL-62 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3wTWM2OD1zLk[wPFYzKM7:TR?= MknYV2FPT0WU
MG-63 NH:5TJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFi5eYpKSzVyPUGuOlE5OTNizszN M3\1dXNCVkeHUh?=
SK-LU-1 NV70bYZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTFwNkKxOVIh|ryP NYT4b2c2W0GQR1XS
BCPAP MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfxTWM2OD1zLk[2OFU4KM7:TR?= M2nOd3NCVkeHUh?=
22RV1 NYnC[pVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPUTWM2OD1zLk[3PFQ{KM7:TR?= M2OxTnNCVkeHUh?=
T47D MmXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVnnPYxlUUN3ME2xMlY5ODZzIN88US=> MkLMV2FPT0WU
MSTO-211H NVj2WZA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYP1PXpTUUN3ME2xMlY6PjB|IN88US=> NHy4b|ZUSU6JRWK=
DEL M2DaXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnifpVKSzVyPUGuO|AzPzNizszN NU\4fJRuW0GQR1XS
H4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLtc3lWUUN3ME2xMlc{OjF{IN88US=> NVjvV5QyW0GQR1XS
CAL-51 NEjTUGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[0UoRKSzVyPUGuO|Q5PTVizszN MX;TRW5ITVJ?
ABC-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFwN{i1PFIh|ryP NIridmxUSU6JRWK=
MZ2-MEL NGPJOZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkGzTWM2OD1zLke5OVQzKM7:TR?= NUHYOYxUW0GQR1XS
YKG-1 NYPVe49ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjCNopFUUN3ME2xMlgyODZzIN88US=> MXHTRW5ITVJ?
KM12 NEjLdWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLrPZhUUUN3ME2xMlgyPjB{IN88US=> M{frcXNCVkeHUh?=
L-363 NEL0ZXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\tNGdKUUN3ME2xMlg4PDF{IN88US=> MVnTRW5ITVJ?
KU812 MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXP[WxKSzVyPUGuPFkzQDJizszN NX3r[VdmW0GQR1XS
LOXIMVI MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHzTWM2OD1zLkmxNlI5KM7:TR?= MXPTRW5ITVJ?
G-401 M2jqVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fKRWlEPTB;MT65NlQzQCEQvF2= MlKxV2FPT0WU
SW780 MkDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTFwOU[yOFYh|ryP MVTTRW5ITVJ?
SW872 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;rT2lEPTB;MT65PFM{KM7:TR?= MoLkV2FPT0WU
NB7 M32xTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;qVWJKSzVyPUGuPVk{OjNizszN Ml;RV2FPT0WU
T98G MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXtbnRoUUN3ME2yMlAxPjZ4IN88US=> NX7EeYh6W0GQR1XS
SW1710 NV3TZ4lwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH74O|FKSzVyPUKuNFY6PDVizszN NIC2PHdUSU6JRWK=
NCI-H1573 MmriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTJwMEeyPVgh|ryP NFfCfFNUSU6JRWK=
KE-37 NWLOOVNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Dic2lEPTB;Mj6wPFk2OSEQvF2= NFXWXGVUSU6JRWK=
786-0 M2\Be2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L3emlEPTB;Mj6xOVQ{QSEQvF2= M{TwRXNCVkeHUh?=
SAS NHnBTFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTJwMkCzO|Qh|ryP NWHCSIFsW0GQR1XS
CAL-54 M1zUNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXiRVBsUUN3ME2yMlIxPDF|IN88US=> NHrZVXNUSU6JRWK=
SF268 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlf2TWM2OD1{LkKzNVIzKM7:TR?= NULtS|VVW0GQR1XS
SW620 MnTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jaSWlEPTB;Mj6yOlE3QSEQvF2= MoDaV2FPT0WU
MN-60 M1vlUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\FTWM2OD1{LkOxNFYh|ryP NEDaZphUSU6JRWK=
EFO-27 M2DRUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoGwTWM2OD1{LkOyNFU5KM7:TR?= NUHQOXNrW0GQR1XS
NCI-H747 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C5PWlEPTB;Mj6zNlE6QSEQvF2= MmDWV2FPT0WU
HCC2218 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjPTWM2OD1{LkO1N|c1KM7:TR?= M4jQZnNCVkeHUh?=
MIA-PaCa-2 NF\IfmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTJwM{[0N|ch|ryP NIrBe2FUSU6JRWK=
SJSA-1 NInmWmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJwM{e3PVYh|ryP MW\TRW5ITVJ?
RKO MoDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTJwM{i0PVYh|ryP M4i2bXNCVkeHUh?=
NB6 NYXzfot7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULsSY1PUUN3ME2yMlQxOzd2IN88US=> MXzTRW5ITVJ?
ES4 NGrZVVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTJwNEW0NlIh|ryP MV\TRW5ITVJ?
EGI-1 Mm\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1eySGlEPTB;Mj60Olg5OyEQvF2= NGXwbGxUSU6JRWK=
CTV-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLnO5F5UUN3ME2yMlUzPzd|IN88US=> NXnmdnVCW0GQR1XS
NCI-H1355 M2P5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n5VmlEPTB;Mj61OVk2OSEQvF2= M4jpU3NCVkeHUh?=
GT3TKB NILOWoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfpdGRXUUN3ME2yMlU6OTl7IN88US=> M1m3cHNCVkeHUh?=
SK-HEP-1 NX3ofVVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTJwNUmyOlYh|ryP MXjTRW5ITVJ?
GAMG NWniepd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVn3ZmhpUUN3ME2yMlU6Ozl2IN88US=> MXXTRW5ITVJ?
SK-MES-1 M4nFSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTLTWM2OD1{Lk[xPFA{KM7:TR?= NEHaWXRUSU6JRWK=
RO82-W-1 NYDVb|d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPsNnZKSzVyPUKuOlIxPTdizszN NH7aZ|FUSU6JRWK=
ECC10 Mo\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTJwN{CyNFYh|ryP NFPXWZpUSU6JRWK=
MCF7 NF7sXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HOZ2lEPTB;Mj63NVQ3PCEQvF2= MXzTRW5ITVJ?
D-283MED NWTDZ29PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\1cHFKSzVyPUKuO|I1OyEQvF2= MmrEV2FPT0WU
RPMI-7951 NHHEXZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Xub2lEPTB;Mj63OVY6PCEQvF2= MVfTRW5ITVJ?
Ramos-2G6-4C10 NXexcVRtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;aOopKSzVyPUKuO|cxQTlizszN NHziblRUSU6JRWK=
KGN NYDnfGo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\GV|EyUUN3ME2yMlgyQDh2IN88US=> NHzVZY9USU6JRWK=
NUGC-3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfFNXVSUUN3ME2yMlgzPTB3IN88US=> MkH0V2FPT0WU
NCI-H292 MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nnN2lEPTB;Mj64OVA2OyEQvF2= M4jPSHNCVkeHUh?=
Becker MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJwOUW4N|Ih|ryP MVvTRW5ITVJ?
NCI-H1299 M1rIemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYGyVFg2UUN3ME2zMlA2OjZ|IN88US=> M1PTcHNCVkeHUh?=
ETK-1 NFXi[XhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3y5dGlEPTB;Mz6wOVQ{KM7:TR?= M3\WZnNCVkeHUh?=
TK10 MmDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3L4fGlEPTB;Mz6yNFE3PSEQvF2= MnfZV2FPT0WU
VMRC-RCZ NXGwclV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYTWWoVqUUN3ME2zMlM3PDh6IN88US=> MXTTRW5ITVJ?
YH-13 NWLVSpJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDBTWM2OD1|LkS0NFc6KM7:TR?= NUPjWGh2W0GQR1XS
DU-145 NGjC[5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37GXmlEPTB;Mz60OlI3QSEQvF2= NV3mN281W0GQR1XS
SW1088 NXHkdpRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fHT2lEPTB;Mz60O|Q4KM7:TR?= MV\TRW5ITVJ?
HOP-92 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTNwNUCzOFIh|ryP M3\BfXNCVkeHUh?=
KP-N-YS NUKyTVBGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\tTWM2OD1|Lk[yNVM6KM7:TR?= NUHRcY4zW0GQR1XS
NCI-H460 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTNwNk[3N{DPxE1? Ml;WV2FPT0WU
U-2-OS M3\ufGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rwcWlEPTB;Mz63NlU{PSEQvF2= MofEV2FPT0WU
A101D M2rwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTWdZhKSzVyPUOuO|Y6OzZizszN MmK5V2FPT0WU
MDA-MB-231 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:wbWlEPTB;Mz64NVk2OSEQvF2= MVfTRW5ITVJ?
IST-MES1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nVO2lEPTB;Mz64N|Ih|ryP NIDUTY5USU6JRWK=
COR-L105 NH7vVHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjZSIJLUUN3ME20MlAyQCEQvF2= NWTwdnc{W0GQR1XS
NCI-H1437 NUTRNnZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTRwMEKzNFIh|ryP NUf6OnloW0GQR1XS
CAL-85-1 NESyZnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{L6e2lEPTB;ND6wNlQ3OSEQvF2= NE\OZ3JUSU6JRWK=
MZ1-PC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzsSmpIUUN3ME20MlE5PTV4IN88US=> MVjTRW5ITVJ?
VM-CUB-1 MmfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;EXmlEPTB;ND6zNVI5PCEQvF2= MnXOV2FPT0WU
CHL-1 NXrTcHNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrjc5htUUN3ME20MlMzOTZ7IN88US=> MXjTRW5ITVJ?
MDA-MB-361 M2OwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTyVVZWUUN3ME20MlM{OTV|IN88US=> MlraV2FPT0WU
NCI-H661 M4nuPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIjwSZNKSzVyPUSuOVAxQTJizszN MlvvV2FPT0WU
EW-11 M{O1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn4bFlKSzVyPUSuOVIzOzFizszN MVLTRW5ITVJ?
BEN MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvw[FVNUUN3ME20MlUzQDF3IN88US=> M2ntdnNCVkeHUh?=
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NCI-H2087 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\nZWlEPTB;ND61PFE3PCEQvF2= M1HoRXNCVkeHUh?=
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SW1573 MlHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTF2LkS0N|Uh|ryP Mlz5V2FPT0WU
KYSE-140 NHnSclVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vK[2lEPTB;MUSuOlMzPyEQvF2= NITlbZZUSU6JRWK=
SK-PN-DW MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\ZTWM2OD1zND64NFAyKM7:TR?= NYnLTIRpW0GQR1XS
A253 NVzWd4l[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF3LkC2NlUh|ryP M{PoT3NCVkeHUh?=
CAL-12T M1u5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\5TWM2OD1zNT60OlYzKM7:TR?= NUOxS5NPW0GQR1XS
COLO-679 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXvTWM2OD1zNT63Olg{KM7:TR?= MWnTRW5ITVJ?
UACC-257 MoGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorZTWM2OD1zNj6xNlAyKM7:TR?= MYLTRW5ITVJ?
U-87-MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC2RXdlUUN3ME2xOk4{PTJ|IN88US=> NWrvVYFKW0GQR1XS
HCC1806 M{DtXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLZR4F6UUN3ME2xOk44ODdzIN88US=> MUDTRW5ITVJ?
NCI-H2170 NGewVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnsZ|F3UUN3ME2xO{4zPDR6IN88US=> MVzTRW5ITVJ?
AGS NF7LV4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3DVnpKSzVyPUG3MlM5ODhizszN NIjQb49USU6JRWK=
MEL-HO NUCwfZBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDMTWM2OD1zNz63OVA{KM7:TR?= M1e5VHNCVkeHUh?=
SW48 NWG0NmhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M171ZmlEPTB;MUeuO|cyPiEQvF2= MnvrV2FPT0WU
HuP-T4 NV\vZ3dFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLXbpNZUUN3ME2xPE4xOjB4IN88US=> NU\5bnBzW0GQR1XS
NCI-H720 M3fDcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzpZ49KSzVyPUG4MlE1ODJizszN MXfTRW5ITVJ?
RCC10RGB MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXQcHBKSzVyPUG4MlE3QTdizszN Mkf2V2FPT0WU
HD-MY-Z M1\k[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M375b2lEPTB;MUiuNlI2PCEQvF2= NYDlXYw5W0GQR1XS
A427 NH3JNYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTF6LkWwPVQh|ryP MljnV2FPT0WU
HCC2998 NHnhRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj0TWM2OD1zOD62NFUyKM7:TR?= M3G5TnNCVkeHUh?=
EPLC-272H NUX5UIdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVr0T|ZqUUN3ME2xPU4xPDN2IN88US=> NXK1ToJDW0GQR1XS
C32 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\KeWlEPTB;MUmuNFQ2KM7:TR?= NYXaTHpnW0GQR1XS
UMC-11 M4nmVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DOVGlEPTB;MUmuNlEzOyEQvF2= Mo\jV2FPT0WU
CaR-1 M2[0N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvSTWM2OD1zOT62PFA1KM7:TR?= NEPzOYtUSU6JRWK=
KYSE-410 NWryPIF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PaZWlEPTB;MUmuPVE{QSEQvF2= MkL3V2FPT0WU
HuCCT1 MnTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXycpFKSzVyPUKwMlYzQTRizszN MVTTRW5ITVJ?
LB996-RCC M3KydWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInSNZpKSzVyPUKwMlcyPjhizszN NHn6emJUSU6JRWK=
KYSE-70 M1PZemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LnVmlEPTB;MkCuPFA2QSEQvF2= Mo\DV2FPT0WU
CAL-72 NWToWW9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHNTWM2OD1{MD65NVUh|ryP MkPSV2FPT0WU
Capan-2 NYDSW|hUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\nVo1KSzVyPUKxMlA1OTNizszN M3HWc3NCVkeHUh?=
PANC-08-13 MoPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY[2e|ZHUUN3ME2yNU4zPTF3IN88US=> NUW5TYMzW0GQR1XS
SBC-1 NFrweG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrnZ|hKSzVyPUKxMlMxQDFizszN NVT5TYpkW0GQR1XS
MFM-223 MoW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\OelFKSzVyPUKxMlM{PDJizszN NVS3XpR7W0GQR1XS
BB49-HNC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjDeG0{UUN3ME2yNU42PzF4IN88US=> MVfTRW5ITVJ?
SH-4 Mn\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTJzLk[2NVgh|ryP MmTPV2FPT0WU
HuO9 M{PFOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j3V2lEPTB;MkGuPVgzPSEQvF2= MV7TRW5ITVJ?
AM-38 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTRTWM2OD1{Mj6wOFg2KM7:TR?= MnjwV2FPT0WU
A431 MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;IcGlEPTB;MkOuNlEyQSEQvF2= NEfCV41USU6JRWK=
YAPC NFfLe21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTJ|LkK2OVEh|ryP NYLQZ2w{W0GQR1XS
LU-139 M1fudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfRc25KSzVyPUKzMlQ5ODlizszN NFLiXYVUSU6JRWK=
HEC-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTJ|LkS5N|ch|ryP MnP0V2FPT0WU
SCC-25 NX;BSnE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLpTWM2OD1{ND6zNFA3KM7:TR?= NGnwXmhUSU6JRWK=
HT-29 MoThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXJTWM2OD1{ND6zPFI{KM7:TR?= MojBV2FPT0WU
PC-14 NWTtcFRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTJ2Lk[1O|Eh|ryP NILvc4RUSU6JRWK=
Calu-6 M3jTVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2e4VmlEPTB;MkWuOVA4OSEQvF2= MoPYV2FPT0WU
SJRH30 MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrXUItKSzVyPUK1MlY1QTZizszN NHmzNmpUSU6JRWK=
ChaGo-K-1 MoXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJ4LkG2Nlkh|ryP NH\5d5NUSU6JRWK=
IA-LM NETPcINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHvTmtwUUN3ME2yOk4{PjR3IN88US=> MkLyV2FPT0WU
GP5d MoLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmf0TWM2OD1{Nj60OFkyKM7:TR?= NELvVGNUSU6JRWK=
NCI-H2291 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHQNXFKSzVyPUK2MlY2PDFizszN NXzUfo9IW0GQR1XS
BALL-1 M4K1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\rfXJDUUN3ME2yOk46Ozl5IN88US=> MoHlV2FPT0WU
HCC1954 NXrQc2VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3e2PWlEPTB;Mk[uPVgxQCEQvF2= MWPTRW5ITVJ?
NCI-H2452 Mm\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vMUGlEPTB;MkeuOFE3OyEQvF2= MU\TRW5ITVJ?
LU-99A MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJ5LkW1PFIh|ryP NUHiTnpFW0GQR1XS
NTERA-S-cl-D1 M1nFd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvFTWM2OD1{Nz63Nlk6KM7:TR?= NY\ER4EyW0GQR1XS
PANC-10-05 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJ5Lke3O|Uh|ryP M{S3RnNCVkeHUh?=
NCI-H2405 M4jLXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MomyTWM2OD1{Nz65N|g4KM7:TR?= M4r6bHNCVkeHUh?=
MDA-MB-415 M2PlO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPSfZFFUUN3ME2yPE41OTN5IN88US=> MoWzV2FPT0WU
NCI-H2342 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTJ6LkWyPFEh|ryP MUnTRW5ITVJ?
TGBC24TKB NF3PNZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnS[pB6UUN3ME2yPE44OTF5IN88US=> MXXTRW5ITVJ?
LU-134-A NX3Yc2QxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPYZ5JKSzVyPUK4MlkzPjFizszN NVfKT5pIW0GQR1XS
SCC-4 NWPwRmszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TrcWlEPTB;M{GuNFQ6PCEQvF2= NET6fY1USU6JRWK=
Saos-2 NHLHZ3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzWTWM2OD1|MT65N|A3KM7:TR?= NGG2RppUSU6JRWK=
RERF-LC-MS M2T6e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmi0TWM2OD1|Mj64NlMyKM7:TR?= NFi2VYxUSU6JRWK=
M14 NFT1WFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXRTWM2OD1|Mj65O|Y1KM7:TR?= Mn;SV2FPT0WU
HPAF-II NYXRS49VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjwNoRoUUN3ME2zN{42ODFzIN88US=> NEDKdmFUSU6JRWK=
NCI-H1755 Mn\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTN2LkOzNFUh|ryP NIru[GZUSU6JRWK=
D-392MG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTN3Lki2O|Qh|ryP MWHTRW5ITVJ?
A704 MofzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXe2NJNuUUN3ME2zOk4xPDJ5IN88US=> NYHyXpBoW0GQR1XS
CP50-MEL-B MmS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfHb4ZYUUN3ME2zOk4yQTFzIN88US=> NYPnW4hkW0GQR1XS
EW-18 M2X2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;YcGF[UUN3ME2zOk41PTJizszN M1L1N3NCVkeHUh?=
WM-115 M3;sVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\tZpRKSzVyPUO2MlgxQTlizszN M2TSc3NCVkeHUh?=
LU-65 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnu[HhPUUN3ME2zO{4yPDF5IN88US=> NYqzVWFlW0GQR1XS
NCI-H1563 Mn7RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXVcZEzUUN3ME2zO{4zPDh2IN88US=> MnzsV2FPT0WU
DBTRG-05MG NXj5RXVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLrWFRKSzVyPUO4MlA3QTFizszN NGLYS21USU6JRWK=
NCI-H630 NGLZPHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\pbGlEPTB;M{iuOFcyPCEQvF2= MWLTRW5ITVJ?
NCI-H1155 NYTSV5pUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTN7LkK0NkDPxE1? MUTTRW5ITVJ?
OVACR-3 M4XmVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTN7LkmxPVUh|ryP M1jHWXNCVkeHUh?=
OAW-42 M4foU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrRTWM2OD12MD60NlU5KM7:TR?= NIXOPHJUSU6JRWK=
JVM-2 NYHubZVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTRzLkK0NVUh|ryP M17jNnNCVkeHUh?=
C3A Mn;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLyVYJKSzVyPUSxMlM1PDdizszN NYnscGNUW0GQR1XS
HT55 NV\uT3JZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjh[GZKSzVyPUSyMlI5PDFizszN M{n4RXNCVkeHUh?=
OVCAR-4 MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTR{LkK5O|Qh|ryP M4C4fHNCVkeHUh?=
MEG-01 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37zRWlEPTB;NEKuOFYyPiEQvF2= NHXke5RUSU6JRWK=
NCI-H82 MlTIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7DNmNKSzVyPUSzMlk5QTJizszN MW\TRW5ITVJ?
JEG-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;pe5FKSzVyPUS0Mlk1PyEQvF2= NUDKPGlvW0GQR1XS
BPH-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXtbHNKSzVyPUS2MlM6QThizszN NIT2c4pUSU6JRWK=
MPP-89 NUnJOmJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LRZmlEPTB;NEeuNlg6QCEQvF2= MWPTRW5ITVJ?
ALL-PO MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTmTWM2OD12Nz60NVg5KM7:TR?= Mo\XV2FPT0WU
HT MnvnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjETWM2OD12Nz60PVIh|ryP MVHTRW5ITVJ?
NCI-H2347 MkG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzEeHVnUUN3ME20PE4xPzF3IN88US=> NVPNZWxQW0GQR1XS
A2780 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MluwTWM2OD12OT60NlI5KM7:TR?= M{DmbXNCVkeHUh?=
KARPAS-299 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjKXlJFUUN3ME20PU42OTF7IN88US=> NYjYcVNxW0GQR1XS
NCI-H1651 M321PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjiWZRQUUN3ME20PU45QDJzIN88US=> MXnTRW5ITVJ?

... Click to View More Cell Line Experimental Data

体内研究 150 mg/kg PD 0332991处理 MDA-MB-435移植瘤完全抑制肿瘤。在多种人类肿瘤移植瘤中,PD 0332991也显示广谱抗癌活性,通过除去血管中p-Rb和增殖Marker Ki-67,且调节基因使其处于E2F转录水平控制。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

Cdk实验:

PD0332991溶解在DMSO中。在96孔板上进行CDK 实验。通过杆状病毒感染,所有的CDK-cyclin 激酶复合体 在昆虫细胞中表达。实验底物为与GST融合的一段pRb。每孔体积为0.1 ml,包含:终浓度为20 mm Tris-HCl(pH 为7.4), 50 mmNaCl, 1 mm二硫苏糖醇, 10 mmMgCl2, 25 μm ATP (用于CDK4-cyclin D1, CDK6-cyclin D2,和CDK6-cyclin D3)或12 μm ATP (用于CDK2-cyclin E, CDK2-cyclin A, 和CDC2-cyclin B),0.25 μCi [γ-32P]ATP, 20 ng 酶, 1 μg GST·RB-Cterm, 及PD 0332991 (0.001-0.1μM)。除了[γ-32P]ATP的所有混合物加到孔中,放在搅拌器上搅拌2分钟。加入 [γ-32P]ATP开始反应, 在25 oC下温育15分钟。加入0.1 ml 20% 三氯乙酸终止反应, 在4 oC维持至少1小时,使底物沉淀。用0.2 ml 10%三氯乙酸冲洗5次,用β-计数器板测定掺入的放射性。
细胞实验:

[1]

+ 展开
  • Cell lines: MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,和K562细胞
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24小时
  • Method:

    肿瘤细胞包括MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,及K562按每孔2×104个细胞接种在96孔板上,温育过夜。加入PD 0332991 (0.01-1 μM) ,37oC温育24小时。每孔加入[14C]胸甘(0.1 μCi) ,进行同位素示踪,持续72小时。用β-计数器板测定掺入的放射性。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 携带晚期人类肿瘤移植瘤,包括结肠-205, MDA-MB-435 乳腺癌, SF-295 恶性胶质瘤, ZR-75-1 乳腺癌, PC-3 前列腺癌, H125 肺癌, SW-620结肠癌, H23肺癌,及MDA-MB-468 乳腺癌 (Rb 阴性)的SCID鼠
  • Formulation: 溶解在乳酸钠buffer(50 mM, pH 4.0)中
  • Dosages: 0-150 mg/kg
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
Saline
20 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 483.99
化学式

C24H29N7O2.HCl

CAS号 827022-32-2
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03007979 Not yet recruiting Breast Cancer|Breast Carcinoma|Cancer of Breast|Malignant Tumor of Breast Washington University School of Medicine February 28, 2017 Phase 2
NCT02907918 Not yet recruiting Breast Cancer|Cancer of Breast|Breast Carcinoma Washington University School of Medicine|Pfizer February 28, 2017 Phase 2
NCT01209598 Completed Sarcoma|Liposarcoma Memorial Sloan Kettering Cancer Center|Pfizer September 23, 2010 Phase 2
NCT03054363 Not yet recruiting Breast Cancer University of Colorado, Denver March 2017 Phase 1|Phase 2
NCT03024489 Not yet recruiting Head and Neck Cancer|Locally Advanced|Unresectable Mahidol University February 2017 Phase 1|Phase 2
NCT02947685 Not yet recruiting HER-2 Positive Breast Cancer|Estrogen Receptor Positive Breast Cancer Alliance Foundation Trials, LLC.|Pfizer|German Breast Group (GBG)|Fondazione Michelangelo|PrECOG, LLC.|The Australia and New Zealand Breast Cancer Trials Group (ANZBCTG)|Alliance Foundation Trials Biorepository - Washington State University|Alliance Foundation Trials Central Imaging Core Lab - Ohio State University|Mastering Breast Cancer Initiative, LLC|Mayo Clinic Statistics and Data Center|INC Research|SOLTI Breast Cancer Research Group February 2017 Phase 3

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常见问题及建议解决方法

  • 问题 1:

    There are two kind of Palbociclibs available: the isethionate salt or the HCl salt. I would like to know which is the main difference between them and what are they more suitable for in terms of experiment type (cell culture or in vivo animals experiments).

  • 回答:

    This two compounds are different Palbociclib salt. S1579 is the Isethionate salt, and the S1116 is the HCl salt. you can use S1116 for oral administration while S1579 is more suitable for I.P. administration.

Related Antibodies

CDK Signaling Pathway Map

CDK Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID