Palbociclib (PD-0332991) HCl

Pfizer辉瑞授权 目录号:S1116

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。

规格 价格 库存 购买数量  
RMB 902.49 现货
RMB 1406.17 现货
RMB 4670.26 现货
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客户使用该产品的8个实验数据:

  • PD-0332991 causes inhibition of proliferation of EAC cells in a dose-dependent manner. Western blots showing the phosphorylation status of pRB at Ser780 and Ser795 after incubation with 125 nmol/L PD-0332991 for 24 and 72 hours. Reduction in cyclin A expression and the expression of RB2 (p130) tumor suppressor 72 hours after PD-0332991 treatment are shown (bottom). Total pRB (RB1) and actin are loading controls and T293 cell lysate (293) is a positive control for total pRB and phospho-pRB (Ph-RB). E, anchorage-independent growth of the 3 cell lines in the presence or absence (Cnt) of 125 nmol/L PD-0332991 for 3 weeks.

    Clin Cancer Res 2011 17(13), 4513-22. Palbociclib (PD-0332991) HCl purchased from Selleck.

    b, c MelJuso cells were treated for 12–48 h with 1 µM Selumetinib or 5 µM Palbociclib and the cells were fixed, stained with propidium iodide and cell cycle distribution was determined by flow cytometry (b) and whole cell extracts were fractionated by SDS-PAGE, transferred onto PVDF membrane and immuno-blotted with the indicated antibodies (c). Data is from a single experiment representative of three separate experiments with similar results. The data in (b) are mean ± S.D. from a single experiment with three replicate dishes of cell per data point; similar results were obtained in two additional experiments

    Cell Mol Life Sci, 2016, 73(4):883-900. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • (A) Percentage of DN3a cells in S-phase (as gated on DAPI profile) from control (Zfp36l1/2fl/fl) and Zfp36l1/2fl/fl; CD2Cre (DCKO) mice, after 1 d of treatment with vector or palbociclib (drug).

    J Immunol, 2016, 197(7):2673-85. Palbociclib (PD-0332991) HCl purchased from Selleck.

     

    Patient tumor cell sensitivity to combinatorial treatment with histone deacetylase (HDAC)/cyclin-dependent kinase (CDK) inhibitors in 3-D culture. The effect of each drug or drug combination was assessed by fluorescent dye to identify live (green) and dead cells (red). Cells from breast reduction patients were used as non-cancer control in the assay.

    Pharmacogenomics J 2013 13(1), 94-104. Palbociclib (PD-0332991) HCl purchased from Selleck.

  •  

    Cdk4 is upregulated in ARMS and mMSCs transfected with PAX7-FKHR fusion gene (MP7F), and can be specifi cally inhibited. D: IF results showing overexpression of cdk4 in MP7F cells compared to parental mMSCs and reduced expression of cdk4 after treatment of MP7F cells with the cdk4 inhibitor, PD-0332991. E: IF results showing MyoD1 expression in parental mMSCs cells, and MP7F cells untreated and after treatment with the cdk4 inhibitor, PD-0332991.

    Clin Transl Oncol 2012 14(3), 197-206 . Palbociclib (PD-0332991) HCl purchased from Selleck.

    WM3734 melanoma cells were treated by PD-0332991 for 36 hours; melanoma cells treated by Doxorubicin (DXR)  at 0.5 μM is included as a control.

     

     

    Dr. Gao Zhang of University of Pennsylvania. Palbociclib (PD-0332991) HCl purchased from Selleck.

  • Serum-deprived T98G glioma cells are restimulated with serum(FBS) with or without 1 μΜ PD-0332991.

     

     

    Dr. Sabine Paternot and Dr Pierre Roger of IRIBHM, ULB, Brussels. Palbociclib (PD-0332991) HCl purchased from Selleck.

    P16INK4A knockdown in INK4A/ARF-wt human glioma cell LN319 potentiates PDGF-Apromoted anchorage-dependent growth in vitro. Soft agar growth of Ink4a/Arf-deficient mAst and LN444 cells treated with PD0332991. (A) IB analysis. (B) Quantification of soft agar assays. β-actin was used as a loading control in all IB experiments. Data are presented as mean ± s.d. and representative of two independent experiments. **, P < 0.01; ***, P < 0.001

    Dr. Kun-Wei Liu from University of Pittsburgh. Palbociclib (PD-0332991) HCl purchased from Selleck.

产品安全说明书

CDK抑制剂选择性比较

生物活性

产品描述 Palbociclib (PD-0332991) HCl是一种高度选择性的CDK4/6抑制剂,无细胞试验中IC50分别为11 nM/16 nM。它对CDK1/2/5,EGFR,FGFR,PDGFR,InsR等没有抑制活性。Phase 3。
特性 PD-0332991作为有应用前景的工具测定CDK激酶是否具有明显的治疗价值。
靶点
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
体外研究

PD 0332991 对其他蛋白激酶包括EGFR, FGFR, PGFR, IR等没有抑制效果。 PD 0332991作用于Cdk4时是非ATP竞争性抑制剂。PD 0332991抑制MDA-MB-435乳腺癌细胞,IC50为66 nM,是由于Rb 在Ser780的磷酸化作用下降。PD 0332991抑制胸苷合并到Rb阳性的人类乳腺癌,结肠癌 肺癌,及白血病的DNA中,IC50值为4 nM到0.17 μM。PD 0332991作用于Rb阴性细胞没有抑制效果。PD 0332991作用于MDA-MB-453乳腺癌细胞和结肠-205细胞使细胞积累在G1期。[1]PD 0332991也有效作用于骨髓瘤5T33MM细胞,使细胞对Bortezomib敏感。[2]PD 0332991抑制luminalER-阳性和HER2-增强的乳腺癌细胞系,包括MDA-MB-175 ZR-75-30 CAMA-1 MDA-MB-134 HCC-202 UACC-893 等等。在这些细胞系中,PD 0332991增强Tamoxifen和Trastuzumab 的活性。在MCF7抗Tamoxifen细胞中,PD 0332991也增强tamoxifen 的敏感性。[3] 最新研究显示PD 0332991可以抑制恶性横纹肌样肿瘤(MRT)细胞系包括MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS,且MRT细胞系对PD 0332991敏感性和p16表达呈负相关。[4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 NYfVS3VzU2mwYYPlJGF{e2G7 MYeyOEBp M3rPd2lvcGmkaYTpc44hd2ZiQ1TLOEBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHJjKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFIh|ryP MUGyOFY1OTFyMx?=
COLO205 NYO2fmtIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYX3VWV1PzJiaB?= M3TGeWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5yM{[g{txO MYiyOFY1OTFyMx?=
U937 Ml\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXKO|IhcA>? M3SxPWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5zNDFOwG0> NGeyfGkzPDZ2MUGwNy=>
MOLM13 Mn\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjHR4hRPzJiaB?= NVi1dpJ2SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDNU2xOOTNiY3XscJMhcGG{Yn;ybY5oKE[OVEOgTXRFKG23dHHueEBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEm2JO69VQ>? MWKyOFY1OTFyMx?=
MOLM13 NHSwN45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[yVI8xPzJiaB?= MkHLRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDzc5Ji\mWwaXKtdoV{cXO2YX70JIh2dWGwIF3PUG0yOyClZXzsd{Bie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEm2JO69VQ>? M3TXSFI1PjRzMUCz
MDA-MB-435 M2\wOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\peHUyOjRiaB?= M4jJbGlEPTB;MD6xOkDPxE1? M362N|E2QDBzOEOx
K562 NVT6U417S3m2b4TvfIlkKEG|c3H5 MkTTPVYhcA>? NUn6ZWF7TE2VTx?= NHizWJpKSzVyPUKg{txO NVjJOoZxOjR2MUe1OlY>
DU145 M4TyNGN6fG:2b4jpZ{BCe3OjeR?= MVq5OkBp NW[1XIxrTE2VTx?= MoDXTWM2OD15LkWg{txO M2jyUFI1PDF5NU[2
MDA-MB-231 M1PLUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTnW4YyKM7:TR?= MWOyOEBp M4XhPGROW09? MULD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|EheGijc3W= NHPqPYszPDRzN{W2Oi=>
MCF7 M4jjcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvJO4ZHOSEQvF2= M33RWFI1KGh? M4jiPWROW09? MYPD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgS|EheGijc3W= MnfyNlQ1OTd3Nk[=
MCF7 MYLLbY5ie2ViQYPzZZk> MU[1JO69VQ>? NF7ESngzPCCq NVHLemZ1TE2VTx?= M3PoR2lvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgR2RMPC:leXPsbY5FOSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKndHnuc4Jt[XO2b33hJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OEC= NYHGT2FvOjR2MUe1OlY>
MDA-MB-231 NIrnWIhMcW6jc3WgRZN{[Xl? M3rEVVUh|ryP MoPmNlQhcA>? MojrSG1UVw>? NGnwTnhKdmirYnn0bY9vKG:oIILlZ49u[mmwYX70JGNFUzRxY4njcIlvTDFiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC{ZYTpco9jdGG|dH;tZUBxcG:|cHjvdplt[XSrb36gZZQhW2W{N{iw M2GwWlI1PDF5NU[2
MDA-MB-231 NUnnenM6TnWwY4Tpc44hSXO|YYm= MonCNU0yOCEQvF2= NVX1fVFwOjRiaB?= MkDFSG1UVw>? MkDQ[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BRSVKSIHPs[YF3[Wen NFSxVIQzPDRzN{W2Oi=>
MCF7 M{LhcWZ2dmO2aX;uJGF{e2G7 NUTJS5pxOS1zMDFOwG0> MUOyOEBp NFHVPVBFVVOR NFHE[WFld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KFCDUmCgZ4xm[X[jZ3W= MYqyOFQyPzV4Nh?=
MDA-MB-231 M17JXGZ2dmO2aX;uJGF{e2G7 NWHwZpZYOC53LUGg{txO MYe0PEBp NGrsemdFVVOR NFLCWm9p[XNibn:gR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMTDwbIF{\Q>? NHzrcoIzPDRzN{W2Oi=>
MCF7 NHnlR3NHfW6ldHnvckBCe3OjeR?= NU[1XYNlOC53LUGg{txO NYm5R25rPDhiaB?= NXi5bZp1TE2VTx?= NXHXeXl7cGG|IH7vJGNmdGxiY4njcIUh[XK{ZYP0JIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEB{fWJvR{GgdIhie2V? MXGyOFQyPzV4Nh?=
697 NUHZ[nlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M130T2lEPTB;MUS4MlM5KG6P MmjtV2FPT0WU
P12-ICHIKAWA MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTl4LkC0JI5O M4PnU3NCVkeHUh?=
NB69 Mm\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnEcZlZUUN3ME2xOlEvQCCwTR?= MX3TRW5ITVJ?
EoL-1 MkjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTF6Nz6yOkBvVQ>? MX\TRW5ITVJ?
BHT-101 NFv6VoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmq0TWM2OD1zOUiuNlUhdk1? MmDMV2FPT0WU
SK-NEP-1 NVry[WxvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJ{MD6wNkBvVQ>? NX;GXm5DW0GQR1XS
MHH-NB-11 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DMfWlEPTB;MkKwMlE6KG6P NUnlT4VJW0GQR1XS
AsPC-1 NWLRbWVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnBT|lKSzVyPUK1Nk42OyCwTR?= NYK4VHAxW0GQR1XS
ES1 NFLz[G5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUX5VFdJUUN3ME2yOVYvOjVibl2= M{i5cnNCVkeHUh?=
LAMA-84 Mk[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjGeYpKSzVyPUK1PE4yQSCwTR?= MULTRW5ITVJ?
MOLT-16 NFnnPYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NICyfVVKSzVyPUK1PE41QSCwTR?= NVv4RoE4W0GQR1XS
ES7 NVvaSo1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITKeHhKSzVyPUK3N{4xQSCwTR?= M1znW3NCVkeHUh?=
KY821 M3TZT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTNzND6xJI5O NWi1TWg3W0GQR1XS
RT-112 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTN{MT6wOUBvVQ>? Mk[5V2FPT0WU
HL-60 Mn61S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrafYs3UUN3ME2zOFAvPjZibl2= MX;TRW5ITVJ?
MOLT-4 NYLIRlBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TFNmlEPTB;M{S1MlE{KG6P Mn3uV2FPT0WU
KARPAS-45 NYDvZWZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3Ha[mlEPTB;M{e2MlE3KG6P M3rUPXNCVkeHUh?=
SK-N-AS NIjhZXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4GwW2lEPTB;M{i3Mlg{KG6P NVz0dZlqW0GQR1XS
CTB-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfmTWM2OD12MEWuNFIhdk1? MojaV2FPT0WU
NKM-1 M1nlbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD1TWM2OD12MUGuPFkhdk1? MVfTRW5ITVJ?
HTC-C3 NEX4TIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTR|Mj65OUBvVQ>? M4Xv[XNCVkeHUh?=
BE-13 MmrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX4TmlKSzVyPUS0OE4zPyCwTR?= NVTmZoh4W0GQR1XS
KOSC-2 MkOwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTR4Nj65JI5O M3vzU3NCVkeHUh?=
NB14 M1r6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTR6Mz61PEBvVQ>? MV3TRW5ITVJ?
CAL-27 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1O5NmlEPTB;NEm0MlU6KG6P M3zXSnNCVkeHUh?=
H9 M{jDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTR7NT60N{BvVQ>? NEXXdJhUSU6JRWK=
RS4-11 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTVyND63N{BvVQ>? MXvTRW5ITVJ?
PA-1 NHPYO3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTVyOT64OkBvVQ>? MlfMV2FPT0WU
MV-4-11 NFHOOWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf6TWM2OD13MUOuPFUhdk1? MnO0V2FPT0WU
OS-RC-2 NF3uWYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTV{MT62NkBvVQ>? NF;JeJBUSU6JRWK=
RPMI-8226 NHnGfZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1K3W2lEPTB;NUK2Mlg3KG6P MW\TRW5ITVJ?
HGC-27 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlu2TWM2OD13NkSuPVkhdk1? NXS3VYxkW0GQR1XS
CHP-212 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT5W2RKSzVyPUW5N{42QSCwTR?= MnnuV2FPT0WU
NB10 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTEWXg2UUN3ME21PVkvOThibl2= MX7TRW5ITVJ?
HH NHzGOZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIOyV25KSzVyPUW5PU41OyCwTR?= M3nyc3NCVkeHUh?=
EW-16 NF\BbIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlP0TWM2OD14MEOuOVIhdk1? NXX4XYJlW0GQR1XS
ES8 Mn:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHVTWM2OD14MEWuNlEhdk1? M1;oW3NCVkeHUh?=
HAL-01 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnuTIx1UUN3ME22NFUvPjdibl2= NHHaRpVUSU6JRWK=
A204 M3vtTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTZ|Mz65NUBvVQ>? NIPCSG9USU6JRWK=
MHH-PREB-1 NUPmbo5UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PsfmlEPTB;NkO2Mlk6KG6P M2O1SHNCVkeHUh?=
EM-2 NEP5b4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTZ3MD62OEBvVQ>? NFqz[|ZUSU6JRWK=
BV-173 NIj6W4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj1TWM2OD14NUKuOFghdk1? MlPPV2FPT0WU
ONS-76 M2HJXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTZ5Nz64NkBvVQ>? MYjTRW5ITVJ?
KM-H2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoC4TWM2OD14OUWuOVQhdk1? NUL2XVgzW0GQR1XS
D-263MG MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TSfWlEPTB;N{G3MlEzKG6P M4Swd3NCVkeHUh?=
ES3 Mk\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn5TWM2OD15MkiuPVMhdk1? MWnTRW5ITVJ?
VA-ES-BJ Moj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrBTGZsUUN3ME23N|IvOjdibl2= Ml;UV2FPT0WU
NBsusSR NEXzfGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jLXmlEPTB;N{SyMlk6KG6P MWnTRW5ITVJ?
NCI-H520 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFSxNWZKSzVyPUe0Ok42OiCwTR?= MX7TRW5ITVJ?
ES5 NXLLR4t2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jTdGlEPTB;N{WyMlghdk1? M1n6TXNCVkeHUh?=
T-24 NY\VVYpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HZVmlEPTB;N{e4MlcyKG6P MVXTRW5ITVJ?
SW962 NGDK[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUD1UJVpUUN3ME24NFgvPjNibl2= MWnTRW5ITVJ?
EW-3 NYn5TmZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nkU2lEPTB;OEC4Mlc3KG6P NXP4OYpxW0GQR1XS
RXF393 MmDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\se2lEPTB;OEGyMlc6KG6P MlXyV2FPT0WU
U251 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\jS2lEPTB;OEGzMlg5KG6P MYnTRW5ITVJ?
CAMA-1 NEX5N5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTh|Mz65OEBvVQ>? NWq0WGJsW0GQR1XS
JVM-3 M1\US2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTh3MT63PEBvVQ>? NHq1S2NUSU6JRWK=
COLO-800 M33Bfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF2xc|JKSzVyPUi5O{44QCCwTR?= NI[z[YxUSU6JRWK=
OVCAR-5 NXnydGw2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzPToZKSzVyPUmwNE4yKG6P M4HocXNCVkeHUh?=
LB1047-RCC NUPvNJRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17ETGlEPTB;OUK3MlU3KG6P NEPjdG9USU6JRWK=
SW954 NGX4N49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zCTmlEPTB;OUK5MlQyKG6P M2jlS3NCVkeHUh?=
J-RT3-T3-5 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVqzTZBLUUN3ME25N|YvODZibl2= M2DlW3NCVkeHUh?=
Mewo NHXFNIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUS3OIx{UUN3ME25N|YvPiCwTR?= MUDTRW5ITVJ?
NCI-H1770 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPF[2lKSzVyPUm0NE42PSCwTR?= NYX5[XI6W0GQR1XS
HO-1-N-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DR[mlEPTB;OU[yMlgyKG6P NE\IPItUSU6JRWK=
HSC-3 M3[2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnze3JuUUN3ME25OlYvPDhibl2= M1j4d3NCVkeHUh?=
TYK-nu NXztR29vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3STWM2OD17OUiuNlUhdk1? M3HSe3NCVkeHUh?=
KYSE-150 MkDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULVR3FjUUN3ME2xMlAxODd4IN88US=> MnLnV2FPT0WU
SN12C NVjJZoFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\VT3BwUUN3ME2xMlAxQDd3IN88US=> M2WzeXNCVkeHUh?=
MOLT-13 NXKzPYo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjwPW9GUUN3ME2xMlAyPDJzIN88US=> MmL4V2FPT0WU
TE-11 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrYWnFKSzVyPUGuNFQ5OTJizszN NWXYS3FDW0GQR1XS
DB MnrzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mor4TWM2OD1zLkC3Nlc{KM7:TR?= M1LmRnNCVkeHUh?=
CAL-39 MkfZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LLXmlEPTB;MT6wO|UzOiEQvF2= NYXHXm9DW0GQR1XS
A3-KAW MoS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NViyOlMyUUN3ME2xMlA5PDB6IN88US=> NWXFcXBnW0GQR1XS
CHP-134 NH\HR21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTpc4dDUUN3ME2xMlEyQDB5IN88US=> NXW1emZmW0GQR1XS
TGW MoXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnOyTWM2OD1zLkGyN|k2KM7:TR?= NWLnS|d{W0GQR1XS
QIMR-WIL M2DmR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTMTWM2OD1zLkGzNVM1KM7:TR?= M1LtRXNCVkeHUh?=
NCI-SNU-1 MlvHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHSRZdKSzVyPUGuNVY{PTRizszN Mn7SV2FPT0WU
CGTH-W-1 MmP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULlZWhQUUN3ME2xMlE4OTh4IN88US=> NGrSdXBUSU6JRWK=
MHH-ES-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPNTWM2OD1zLkG3PVg3KM7:TR?= MX\TRW5ITVJ?
LB2241-RCC M17E[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTFwMUi2NkDPxE1? M1PNcHNCVkeHUh?=
ML-2 M4\GOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDYR49TUUN3ME2xMlIxPzN2IN88US=> MkHiV2FPT0WU
COR-L23 M2PhWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1W3S2lEPTB;MT6yNlk{OyEQvF2= M1LXZ3NCVkeHUh?=
BFTC-905 NYD0RXhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nvV2lEPTB;MT6yOFI3PyEQvF2= Mn\vV2FPT0WU
Hs-578-T M4PmdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTFwMkW4NVch|ryP NHfRN3NUSU6JRWK=
KG-1 M1rTTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nQT2lEPTB;MT6yOlY5PiEQvF2= MnXRV2FPT0WU
HEL NEnncGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjo[FQzUUN3ME2xMlI6OzN6IN88US=> NVzKXYRYW0GQR1XS
A549 M17xUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIG0c21KSzVyPUGuNlk{QTlizszN M{HCU3NCVkeHUh?=
COLO-741 M4PyfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTFwM{KwPFkh|ryP MkT3V2FPT0WU
PC-3 NGezZYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTFwM{WyNlEh|ryP M{PkXHNCVkeHUh?=
HOS NYj1UopqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fGdmlEPTB;MT6zOVI6PiEQvF2= NF;2WWRUSU6JRWK=
HT-1080 M1vKeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nwW2lEPTB;MT6zO|UyQSEQvF2= M3TheXNCVkeHUh?=
TE-8 NIHwR|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LYdWlEPTB;MT60NVc4PCEQvF2= M4jnUXNCVkeHUh?=
BHY NF;6SVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfRSlFbUUN3ME2xMlQ3QTJ|IN88US=> MYfTRW5ITVJ?
BB65-RCC M2LtOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF:0dlNKSzVyPUGuOVA2OjhizszN MVXTRW5ITVJ?
HN NEG3fpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVq3dXdMUUN3ME2xMlU1ODdzIN88US=> NFH0[lZUSU6JRWK=
NCI-H441 NHTMSm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DseGlEPTB;MT61OFkxPyEQvF2= MnSzV2FPT0WU
RPMI-8866 NXf1PZllT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTFwNUi1NFch|ryP NXThTmFoW0GQR1XS
CAL-62 NFnxNWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGW4TW9KSzVyPUGuOlA5PjJizszN MYXTRW5ITVJ?
MG-63 NEDLT2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlqxTWM2OD1zLk[xPFE{KM7:TR?= M3iwXXNCVkeHUh?=
SK-LU-1 M{P5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDQTWM2OD1zLk[yNVUzKM7:TR?= M2j1enNCVkeHUh?=
BCPAP NUWyNoxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NETUOm1KSzVyPUGuOlY1PTdizszN M2LKVXNCVkeHUh?=
22RV1 MnztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml2yTWM2OD1zLk[3PFQ{KM7:TR?= M{DEdXNCVkeHUh?=
T47D MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTFwNkiwOlEh|ryP NVG3OXZEW0GQR1XS
MSTO-211H MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTFwNkm2NFMh|ryP MnHFV2FPT0WU
DEL NIDWbWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnGTWM2OD1zLkewNlc{KM7:TR?= M37ienNCVkeHUh?=
H4 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zLVGlEPTB;MT63N|IyOiEQvF2= M{XHZXNCVkeHUh?=
CAL-51 NFvGTWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlrZTWM2OD1zLke0PFU2KM7:TR?= M2DQdXNCVkeHUh?=
ABC-1 NV3CTFBKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEW1fJpKSzVyPUGuO|g2QDJizszN MXHTRW5ITVJ?
MZ2-MEL NXq1fYJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVviRoNnUUN3ME2xMlc6PTR{IN88US=> MorXV2FPT0WU
YKG-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTFwOEGwOlEh|ryP MmDoV2FPT0WU
KM12 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTFwOEG2NFIh|ryP MVfTRW5ITVJ?
L-363 M1j1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXyydpRxUUN3ME2xMlg4PDF{IN88US=> MnXvV2FPT0WU
KU812 MkH3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3lTWM2OD1zLki5NlgzKM7:TR?= NXnZcVhrW0GQR1XS
LOXIMVI M2KwU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWO4WIRQUUN3ME2xMlkyOjJ6IN88US=> MVHTRW5ITVJ?
G-401 MnjjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPIVndKSzVyPUGuPVI1OjhizszN M1f5TXNCVkeHUh?=
SW780 M1riOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTFwOU[yOFYh|ryP MnXLV2FPT0WU
SW872 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFwOUizN{DPxE1? M2TSNXNCVkeHUh?=
NB7 NHPENVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\tb|RJUUN3ME2xMlk6OzJ|IN88US=> MlXGV2FPT0WU
T98G MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTJwMEC2OlYh|ryP NXTqd4M3W0GQR1XS
SW1710 NVrzZ2F6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTvTWM2OD1{LkC2PVQ2KM7:TR?= MX\TRW5ITVJ?
NCI-H1573 MmLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJwMEeyPVgh|ryP M{Die3NCVkeHUh?=
KE-37 NFmzNJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;zTWM2OD1{LkC4PVUyKM7:TR?= MXzTRW5ITVJ?
786-0 MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3GTWM2OD1{LkG1OFM6KM7:TR?= NG[2fWhUSU6JRWK=
SAS MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFO2XpRKSzVyPUKuNlA{PzRizszN NFnUSmdUSU6JRWK=
CAL-54 MonVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LEUmlEPTB;Mj6yNFQyOyEQvF2= M{DvNXNCVkeHUh?=
SF268 Mn:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq1TWtKSzVyPUKuNlMyOjJizszN MlHEV2FPT0WU
SW620 M{K4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjsSZd4UUN3ME2yMlI3OTZ7IN88US=> MVPTRW5ITVJ?
MN-60 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmq1TWM2OD1{LkOxNFYh|ryP NWTQZY1rW0GQR1XS
EFO-27 NXzsVXVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rjRWlEPTB;Mj6zNlA2QCEQvF2= NEK3WVdUSU6JRWK=
NCI-H747 M{nEeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJwM{KxPVkh|ryP NH;EO3hUSU6JRWK=
HCC2218 NFj5[ndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTJwM{WzO|Qh|ryP MkXrV2FPT0WU
MIA-PaCa-2 NFz3R2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPXS49KSzVyPUKuN|Y1OzdizszN NYj6dnVSW0GQR1XS
SJSA-1 NX\nNoVjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmftTWM2OD1{LkO3O|k3KM7:TR?= MYTTRW5ITVJ?
RKO NWnlNIk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTJwM{i0PVYh|ryP MXHTRW5ITVJ?
NB6 NUfMOpNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlH2TWM2OD1{LkSwN|c1KM7:TR?= MWfTRW5ITVJ?
ES4 MmDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfFTWM2OD1{LkS1OFIzKM7:TR?= NWL0U2pKW0GQR1XS
EGI-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\HfmlEPTB;Mj60Olg5OyEQvF2= NX:1NVJ6W0GQR1XS
CTV-1 MmjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojpTWM2OD1{LkWyO|c{KM7:TR?= MnfEV2FPT0WU
NCI-H1355 NGfzOZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHG[3RKSzVyPUKuOVU6PTFizszN MVfTRW5ITVJ?
GT3TKB NHfjXG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVn6VGROUUN3ME2yMlU6OTl7IN88US=> Mli5V2FPT0WU
SK-HEP-1 MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJwNUmyOlYh|ryP M{\uXHNCVkeHUh?=
GAMG MmW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPuVVlKSzVyPUKuOVk{QTRizszN NEfae3RUSU6JRWK=
SK-MES-1 NH;PTWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnvSYNKSzVyPUKuOlE5ODNizszN NH3VOmZUSU6JRWK=
RO82-W-1 M{G0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJwNkKwOVch|ryP MULTRW5ITVJ?
ECC10 M1roPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofGTWM2OD1{LkewNlA3KM7:TR?= MXHTRW5ITVJ?
MCF7 M4LhcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PsSWlEPTB;Mj63NVQ3PCEQvF2= MYPTRW5ITVJ?
D-283MED NYLEfXZ1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV72PZlOUUN3ME2yMlczPDNizszN MYDTRW5ITVJ?
RPMI-7951 Ml7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DyR2lEPTB;Mj63OVY6PCEQvF2= NXTPc491W0GQR1XS
Ramos-2G6-4C10 MmjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonZTWM2OD1{Lke3NFk6KM7:TR?= NVzJfnpDW0GQR1XS
KGN MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXleYxjUUN3ME2yMlgyQDh2IN88US=> NInaWoZUSU6JRWK=
NUGC-3 NXzv[2dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTJwOEK1NFUh|ryP NEH3UHRUSU6JRWK=
NCI-H292 Mo\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTJwOEWwOVMh|ryP MXTTRW5ITVJ?
Becker M4TyWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELRS3JKSzVyPUKuPVU5OzJizszN M2rHNnNCVkeHUh?=
NCI-H1299 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTNwMEWyOlMh|ryP Ml[0V2FPT0WU
ETK-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTNwMEW0N{DPxE1? M1TINHNCVkeHUh?=
TK10 NVjzO|V[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{D0[mlEPTB;Mz6yNFE3PSEQvF2= MlKzV2FPT0WU
VMRC-RCZ MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkX0TWM2OD1|LkO2OFg5KM7:TR?= NFf6N2RUSU6JRWK=
YH-13 NWjUcIFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojWTWM2OD1|LkS0NFc6KM7:TR?= MmjlV2FPT0WU
DU-145 NGDVdFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXnTWM2OD1|LkS2NlY6KM7:TR?= M3[3fXNCVkeHUh?=
SW1088 NUDGWolZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPDTWM2OD1|LkS3OFch|ryP MkH2V2FPT0WU
HOP-92 NWLwfoRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTNwNUCzOFIh|ryP MYfTRW5ITVJ?
KP-N-YS NWLlbFB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn[wTWM2OD1|Lk[yNVM6KM7:TR?= NGPiOFVUSU6JRWK=
NCI-H460 NEmzRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTNwNk[3N{DPxE1? MU\TRW5ITVJ?
U-2-OS Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTNwN{K1N|Uh|ryP NYHwcIpGW0GQR1XS
A101D M3\0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjx[IV7UUN3ME2zMlc3QTN4IN88US=> MYnTRW5ITVJ?
MDA-MB-231 MlHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTNwOEG5OVEh|ryP M1rxbXNCVkeHUh?=
IST-MES1 NVy4cXBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGe1S2lKSzVyPUOuPFMzKM7:TR?= NXe4S5JkW0GQR1XS
COR-L105 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi0ZWtUUUN3ME20MlAyQCEQvF2= NH3hRVZUSU6JRWK=
NCI-H1437 NF;OWnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP6TWM2OD12LkCyN|AzKM7:TR?= MoK5V2FPT0WU
CAL-85-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnMOlZiUUN3ME20MlAzPDZzIN88US=> NHHiV2FUSU6JRWK=
MZ1-PC MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlriTWM2OD12LkG4OVU3KM7:TR?= Ml7rV2FPT0WU
VM-CUB-1 NELJ[G9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zxc2lEPTB;ND6zNVI5PCEQvF2= NWTicoFIW0GQR1XS
CHL-1 M4DRd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorzTWM2OD12LkOyNVY6KM7:TR?= MYDTRW5ITVJ?
MDA-MB-361 M1mzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjR[GhKSzVyPUSuN|MyPTNizszN NF;5eldUSU6JRWK=
NCI-H661 M3nrWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTRwNUCwPVIh|ryP NXPnSY5iW0GQR1XS
EW-11 M{DqeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;kTWM2OD12LkWyNlMyKM7:TR?= NYTweGd[W0GQR1XS
BEN M1zORmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1G0fmlEPTB;ND61NlgyPSEQvF2= MVvTRW5ITVJ?
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SW1573 MornS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfTdotKSzVyPUG0MlQ1OzVizszN NY\vdXloW0GQR1XS
KYSE-140 NVPSV|NrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTF2Lk[zNlch|ryP M{[wWHNCVkeHUh?=
SK-PN-DW M3zmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi5TWM2OD1zND64NFAyKM7:TR?= M{TkZnNCVkeHUh?=
A253 NXfpWY42T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHLUYxKSzVyPUG1MlA3OjVizszN NYn0[nBWW0GQR1XS
CAL-12T MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLJN|BKSzVyPUG1MlQ3PjJizszN MYnTRW5ITVJ?
COLO-679 NGrSW4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDrNFJbUUN3ME2xOU44Pjh|IN88US=> M3rDZnNCVkeHUh?=
UACC-257 NYjOSG9QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTF4LkGyNFEh|ryP MofuV2FPT0WU
U-87-MG M2DXOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjPfINxUUN3ME2xOk4{PTJ|IN88US=> M1XSZ3NCVkeHUh?=
HCC1806 NF3QUm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n2ZWlEPTB;MU[uO|A4OSEQvF2= M1\MenNCVkeHUh?=
NCI-H2170 M1fMeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\qTWM2OD1zNz6yOFQ5KM7:TR?= MkTxV2FPT0WU
AGS MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[0SGlEPTB;MUeuN|gxQCEQvF2= NWXJTVd1W0GQR1XS
MEL-HO MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTF5Lke1NFMh|ryP NFOwZYRUSU6JRWK=
SW48 NIHkRXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHHT2J7UUN3ME2xO{44PzF4IN88US=> MWDTRW5ITVJ?
HuP-T4 NVrz[4hJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LROWlEPTB;MUiuNFIxPiEQvF2= NG\LboJUSU6JRWK=
NCI-H720 NFf5OG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHM[mhKSzVyPUG4MlE1ODJizszN M4HkO3NCVkeHUh?=
RCC10RGB M4PPZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDFd2h7UUN3ME2xPE4yPjl5IN88US=> NF;YTWZUSU6JRWK=
HD-MY-Z MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlriTWM2OD1zOD6yNlU1KM7:TR?= M13IRXNCVkeHUh?=
A427 MmjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHJV41KSzVyPUG4MlUxQTRizszN MV3TRW5ITVJ?
HCC2998 NFvydYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TM[2lEPTB;MUiuOlA2OSEQvF2= MV\TRW5ITVJ?
EPLC-272H NWPBfmNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjxW3VKSzVyPUG5MlA1OzRizszN Mnu0V2FPT0WU
C32 NFT1RlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYn4[FVVUUN3ME2xPU4xPDVizszN M2iwbHNCVkeHUh?=
UMC-11 Mkn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTF7LkKxNlMh|ryP NH;5c2VUSU6JRWK=
CaR-1 M3v3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;zfGlEPTB;MUmuOlgxPCEQvF2= MkPaV2FPT0WU
KYSE-410 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLiTWM2OD1zOT65NVM6KM7:TR?= NGXhO4pUSU6JRWK=
HuCCT1 M3vRWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnyxTWM2OD1{MD62Nlk1KM7:TR?= M4XMSHNCVkeHUh?=
LB996-RCC M2DGPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXsTWM2OD1{MD63NVY5KM7:TR?= MXfTRW5ITVJ?
KYSE-70 NGDhVlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NICxTGpKSzVyPUKwMlgxPTlizszN M2TUWHNCVkeHUh?=
CAL-72 M37yemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTJyLkmxOUDPxE1? MVzTRW5ITVJ?
Capan-2 NHHzPYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3qTWM2OD1{MT6wOFE{KM7:TR?= MmTTV2FPT0WU
PANC-08-13 NVH0c2I{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;DTWM2OD1{MT6yOVE2KM7:TR?= MVjTRW5ITVJ?
SBC-1 NHm2UHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\3WXJKSzVyPUKxMlMxQDFizszN MUPTRW5ITVJ?
MFM-223 NXzMZ5RyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\Ve2lEPTB;MkGuN|M1OiEQvF2= M2THPXNCVkeHUh?=
BB49-HNC MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfhbmtKSzVyPUKxMlU4OTZizszN M{\qTXNCVkeHUh?=
SH-4 NX\rVFhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HvS2lEPTB;MkGuOlYyQCEQvF2= MYfTRW5ITVJ?
HuO9 M1LyNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXjUm9KSzVyPUKxMlk5OjVizszN NUHqZXRwW0GQR1XS
AM-38 NVnPWWpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHm0RnFKSzVyPUKyMlA1QDVizszN NXzSb|BTW0GQR1XS
A431 NXnaVIR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfwPHZKSzVyPUKzMlIyOTlizszN NWXTWFB[W0GQR1XS
YAPC MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;WTWM2OD1{Mz6yOlUyKM7:TR?= NW\LdHl7W0GQR1XS
LU-139 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTETWM2OD1{Mz60PFA6KM7:TR?= M{nkR3NCVkeHUh?=
HEC-1 NUPGeHV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK4WXUxUUN3ME2yN{41QTN5IN88US=> MlT3V2FPT0WU
SCC-25 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP6TZlKSzVyPUK0MlMxODZizszN M1f0[nNCVkeHUh?=
HT-29 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULh[VdzUUN3ME2yOE4{QDJ|IN88US=> NX\ZVlBoW0GQR1XS
PC-14 M3izS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[xXlRYUUN3ME2yOE43PTdzIN88US=> MUPTRW5ITVJ?
Calu-6 NX[yfo1GT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYeyNYc1UUN3ME2yOU42ODdzIN88US=> M33heHNCVkeHUh?=
SJRH30 NH3MNolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTJ3Lk[0PVYh|ryP MV;TRW5ITVJ?
ChaGo-K-1 M1zlfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHhTWM2OD1{Nj6xOlI6KM7:TR?= NFvW[HFUSU6JRWK=
IA-LM NXrBeodwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlviTWM2OD1{Nj6zOlQ2KM7:TR?= NHvUPVlUSU6JRWK=
GP5d M4TzdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn1fXA1UUN3ME2yOk41PDlzIN88US=> NGn1e3hUSU6JRWK=
NCI-H2291 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TPXGlEPTB;Mk[uOlU1OSEQvF2= M13wWnNCVkeHUh?=
BALL-1 NHrwSldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTJ4LkmzPVch|ryP MoXLV2FPT0WU
HCC1954 M2Sy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfqTWM2OD1{Nj65PFA5KM7:TR?= NHjV[5dUSU6JRWK=
NCI-H2452 M2i4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrmTWM2OD1{Nz60NVY{KM7:TR?= MYTTRW5ITVJ?
LU-99A M4q5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D3emlEPTB;MkeuOVU5OiEQvF2= MWTTRW5ITVJ?
NTERA-S-cl-D1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf6SGVvUUN3ME2yO{44Ojl7IN88US=> MXfTRW5ITVJ?
PANC-10-05 NV3ZOGFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX70PYFnUUN3ME2yO{44Pzd3IN88US=> NFrCcHNUSU6JRWK=
NCI-H2405 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1eyXmlEPTB;MkeuPVM5PyEQvF2= Ml\ZV2FPT0WU
MDA-MB-415 M1zHUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XNNmlEPTB;MkiuOFE{PyEQvF2= MYHTRW5ITVJ?
NCI-H2342 NHvVcGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3u[HFMUUN3ME2yPE42OjhzIN88US=> MXHTRW5ITVJ?
TGBC24TKB M3LkbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTJ6LkexNVch|ryP MnLPV2FPT0WU
LU-134-A M2\Lcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[3SlR[UUN3ME2yPE46OjZzIN88US=> NYjnUmxSW0GQR1XS
SCC-4 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTNzLkC0PVQh|ryP M1TLV3NCVkeHUh?=
Saos-2 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\WXWlEPTB;M{GuPVMxPiEQvF2= NELocY5USU6JRWK=
RERF-LC-MS Mln3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1uzVGlEPTB;M{KuPFI{OSEQvF2= NITFZWNUSU6JRWK=
M14 M2nmU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLzSZdKSzVyPUOyMlk4PjRizszN MVnTRW5ITVJ?
HPAF-II M2[y[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLSeotnUUN3ME2zN{42ODFzIN88US=> NF3idYdUSU6JRWK=
NCI-H1755 NXrXd|JST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTN2LkOzNFUh|ryP MXrTRW5ITVJ?
D-392MG NYrrVVRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTN3Lki2O|Qh|ryP MkjvV2FPT0WU
A704 MkfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDhfXNKSzVyPUO2MlA1OjdizszN NEHxemlUSU6JRWK=
CP50-MEL-B MnPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETDSWZKSzVyPUO2MlE6OTFizszN NGnpe2dUSU6JRWK=
EW-18 Mn;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH4SmFKSzVyPUO2MlQ2OiEQvF2= NWXqOW5pW0GQR1XS
WM-115 NYjsZno{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7QNGp4UUN3ME2zOk45ODl7IN88US=> Ml3tV2FPT0WU
LU-65 M1LBS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jQcWlEPTB;M{euNVQyPyEQvF2= M4nKbnNCVkeHUh?=
NCI-H1563 NF;HXpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfqOXc6UUN3ME2zO{4zPDh2IN88US=> MXvTRW5ITVJ?
DBTRG-05MG NUnhS4NXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTN6LkC2PVEh|ryP MXTTRW5ITVJ?
NCI-H630 NI[2UI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi0dHpzUUN3ME2zPE41PzF2IN88US=> M{jidHNCVkeHUh?=
NCI-H1155 MmWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjUTWM2OD1|OT6yOFIh|ryP MUfTRW5ITVJ?
OVACR-3 NUfwcpJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\x[2lEPTB;M{muPVE6PSEQvF2= MUPTRW5ITVJ?
OAW-42 M17Y[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX63PXVzUUN3ME20NE41OjV6IN88US=> M2qzOnNCVkeHUh?=
JVM-2 M4PPWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXud3hKSzVyPUSxMlI1OTVizszN MXfTRW5ITVJ?
C3A MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPkXmVMUUN3ME20NU4{PDR5IN88US=> NFrwdWlUSU6JRWK=
HT55 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGK4O2NKSzVyPUSyMlI5PDFizszN NFK3eYlUSU6JRWK=
OVCAR-4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPpWHBVUUN3ME20Nk4zQTd2IN88US=> MWHTRW5ITVJ?
MEG-01 NXLhWI9CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHpVXlZUUN3ME20Nk41PjF4IN88US=> NFm3e25USU6JRWK=
NCI-H82 NH7nWWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTHVXVqUUN3ME20N{46QDl{IN88US=> MWLTRW5ITVJ?
JEG-3 NXm3RmpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[we4pKSzVyPUS0Mlk1PyEQvF2= MkX0V2FPT0WU
BPH-1 M3\nVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTR4LkO5PVgh|ryP NI\zcYhUSU6JRWK=
MPP-89 M{Lvbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTkTWM2OD12Nz6yPFk5KM7:TR?= NYnYdFF2W0GQR1XS
ALL-PO MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX[5W5ZxUUN3ME20O{41OTh6IN88US=> MUHTRW5ITVJ?
HT M2n4O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTR5LkS5NkDPxE1? NY[5OFZpW0GQR1XS
NCI-H2347 NESzbpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\CUpNKSzVyPUS4MlA4OTVizszN M3T4b3NCVkeHUh?=
A2780 NGOwfWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfzXnJnUUN3ME20PU41OjJ6IN88US=> M2PEc3NCVkeHUh?=
KARPAS-299 NYfSS2FPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG[3dXRKSzVyPUS5MlUyOTlizszN NH3Ze2lUSU6JRWK=
NCI-H1651 NUfQeFZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2WxdmlEPTB;NEmuPFgzOSEQvF2= M3LBV3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

体内研究 150 mg/kg PD 0332991处理 MDA-MB-435移植瘤完全抑制肿瘤。在多种人类肿瘤移植瘤中,PD 0332991也显示广谱抗癌活性,通过除去血管中p-Rb和增殖Marker Ki-67,且调节基因使其处于E2F转录水平控制。[1]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

+ 展开

Cdk实验:

PD0332991溶解在DMSO中。在96孔板上进行CDK 实验。通过杆状病毒感染,所有的CDK-cyclin 激酶复合体 在昆虫细胞中表达。实验底物为与GST融合的一段pRb。每孔体积为0.1 ml,包含:终浓度为20 mm Tris-HCl(pH 为7.4), 50 mmNaCl, 1 mm二硫苏糖醇, 10 mmMgCl2, 25 μm ATP (用于CDK4-cyclin D1, CDK6-cyclin D2,和CDK6-cyclin D3)或12 μm ATP (用于CDK2-cyclin E, CDK2-cyclin A, 和CDC2-cyclin B),0.25 μCi [γ-32P]ATP, 20 ng 酶, 1 μg GST·RB-Cterm, 及PD 0332991 (0.001-0.1μM)。除了[γ-32P]ATP的所有混合物加到孔中,放在搅拌器上搅拌2分钟。加入 [γ-32P]ATP开始反应, 在25 oC下温育15分钟。加入0.1 ml 20% 三氯乙酸终止反应, 在4 oC维持至少1小时,使底物沉淀。用0.2 ml 10%三氯乙酸冲洗5次,用β-计数器板测定掺入的放射性。
细胞实验:

[1]

+ 展开
  • Cell lines: MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,和K562细胞
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24小时
  • Method:

    肿瘤细胞包括MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM,及K562按每孔2×104个细胞接种在96孔板上,温育过夜。加入PD 0332991 (0.01-1 μM) ,37oC温育24小时。每孔加入[14C]胸甘(0.1 μCi) ,进行同位素示踪,持续72小时。用β-计数器板测定掺入的放射性。


    (Only for Reference)
动物实验:

[1]

+ 展开
  • Animal Models: 携带晚期人类肿瘤移植瘤,包括结肠-205, MDA-MB-435 乳腺癌, SF-295 恶性胶质瘤, ZR-75-1 乳腺癌, PC-3 前列腺癌, H125 肺癌, SW-620结肠癌, H23肺癌,及MDA-MB-468 乳腺癌 (Rb 阴性)的SCID鼠
  • Formulation: 溶解在乳酸钠buffer(50 mM, pH 4.0)中
  • Dosages: 0-150 mg/kg
  • Administration: 口服饲喂
    (Only for Reference)

溶解度 (25°C)

体外 Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
Saline
20 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 483.99
化学式

C24H29N7O2.HCl

CAS号 827022-32-2
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03007979 Not yet recruiting Breast Cancer|Breast Carcinoma|Cancer of Breast|Malignant Tumor of Breast Washington University School of Medicine February 28, 2017 Phase 2
NCT02907918 Not yet recruiting Breast Cancer|Cancer of Breast|Breast Carcinoma Washington University School of Medicine|Pfizer February 28, 2017 Phase 2
NCT01209598 Completed Sarcoma|Liposarcoma Memorial Sloan Kettering Cancer Center|Pfizer September 23, 2010 Phase 2
NCT03054363 Not yet recruiting Breast Cancer University of Colorado, Denver March 2017 Phase 1|Phase 2
NCT03024489 Not yet recruiting Head and Neck Cancer|Locally Advanced|Unresectable Mahidol University February 2017 Phase 1|Phase 2
NCT02947685 Not yet recruiting HER-2 Positive Breast Cancer|Estrogen Receptor Positive Breast Cancer Alliance Foundation Trials, LLC.|Pfizer|German Breast Group (GBG)|Fondazione Michelangelo|PrECOG, LLC.|The Australia and New Zealand Breast Cancer Trials Group (ANZBCTG)|Alliance Foundation Trials Biorepository - Washington State University|Alliance Foundation Trials Central Imaging Core Lab - Ohio State University|Mastering Breast Cancer Initiative, LLC|Mayo Clinic Statistics and Data Center|INC Research|SOLTI Breast Cancer Research Group February 2017 Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID