CHIR-99021 (CT99021) HCl

目录号:S2924

CHIR-99021 (CT99021) HCl Chemical Structure

Molecular Weight(MW): 501.8

CHIR-99021 (CT99021) HCl是CHIR-99021的盐酸盐, 是GSK-3α/β抑制剂,IC50为10 nM/6.7 nM。 其对GSK-3的选择性比对Cdc2和ERK2高500倍以上。

规格 价格 库存 购买数量  
RMB 2780.99 现货
RMB 733.53 现货
RMB 1373.92 现货
RMB 4650.09 现货
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客户购买Selleck的此次产品后发表的文献71篇:

客户使用该产品的9个实验数据:

  • Differentiation induced by treatment with the Gsk3 inhibitor in hPSCs is β-catenin dependent. H9-7TGP cells were treated with 12 uM CH in mTeSR1 for 4 d. Immunofluorescent staining for Oct4, Isl1, and Nkx2.5 was compared with GFP expression. (Scale bars, 50 uM.)

    Proc Natl Acad Sci U S A 2012 109(27):E1848-57. CHIR-99021 (CT99021) HCl purchased from Selleck.

    Gpc4 regulates ESC response to Wnt/β-catenin signaling.  (E) Quantitative analysis of control and Gpc4-mutant beating foci exposed to the GSK3 inhibitor, CHIR 99021 (1 and 3 μM, from day 0 to day 5). Analysis was done at different time points. Gpc4- mutant cells treated with CHIR 99021 behave as controls (mean±SEM; n=2).

    Stem Cells 2012 30, 1863-1874. CHIR-99021 (CT99021) HCl purchased from Selleck.

  • Inhibition of GSK3 activity induces an autophagic response in human pancreatic cancer cells. PANC1 cells were treated for 24 h with DMSO, CHIR99021 (CHIR; 5 uM) or the mTOR inhibitor Torin1 (250 nM). Autophagosome (punctate LC3B) (D) and lysosome (E) labeling was visualized with a Zeiss LSM700 confocal microscope. Images were acquired with a 20x (D) or 63x (E) objective. Nuclei were stained with DAPI. Scale bars, 20 祄.

    J Biol Chem 2015 290(9), 5592-605 . CHIR-99021 (CT99021) HCl purchased from Selleck.

     

    Characterization of rES cells. A: image of normal rES cell colonies on feeder layers. B: rES colonies were positive for AP staining. CeE: rES colonies readily expressed pluripotent markers, Sox2 (C), Oct4 (D), and SSEA-1 (E). Blue, DAPI. Scale bars: 100 um.

    J Genet Genomics 2012 39, 643e651. CHIR-99021 (CT99021) HCl purchased from Selleck.

  •  

    Smad linker phosphorylation involves GSK3 in human melanoma lines. Inhibition of Smad2 and Smad3 linker phosphorylation in the presence of the specific GSK3 specific inhibitor, CT99021. 24 hours post seeding, WM793 and 1205LU cells were serum-starved for about 16 hours, and incubated in the absence (2) or presence (+) of 2 uM of CT99021 for two hours. Immunoblots were performed as in A. p: Phosphorylated. S: Serine; T: Threonine.

    PLoS One 2012 7, e47312. CHIR-99021 (CT99021) HCl purchased from Selleck.

    A. Vero cells were pretreated with the indicated concentrations of CHIR-99021 for 1 h and then infected with PEDV (MOI = 1) for 8 or 10 h. Cell lysates were prepared and analyzed using Western blotting.

    PLoS One, 2016, 11(8):e0161508. CHIR-99021 (CT99021) HCl purchased from Selleck.

  • SKOV3/DDP cells were treated with a range of concentration of (A) CHIR-99021 or in combination with 20 µM cisplatin for 48 h.

    Exp Ther Med, 2016, 12(6):3851-3858. CHIR-99021 (CT99021) HCl purchased from Selleck.

     

    PANC1 cells were treated with GSK3 inhibitors SB216763 (SB 10µM or SB 20µM) or CHIR99021 (CHIR 5µM) for 72h.

    CHIR-99021 (CT99021) HCl purchased from Selleck.

  •  

     Activity of canonical WNT/ β -CATENIN signals induced by CHIR 99021 in the developing human lung. Human lung tissue explants obtained at 15 weeks of gestation were exposed to 0, 5 and 10 μM CHIR 99021 in vitro for 72 h. (A-B) Western blot analysis showed expression of β -CATENIN in human lung tissues. Results are presented as the mean ± sem of three independent experiments. *P < 0.05, **P < 0.01. (C) qRT-PCR analysis detected a dose-dependent increase in WNT signaling transcription factors and target genes following exposure to CHIR 99021. Results are presented as the mean ± sem of three independent experiments. *P < 0.05, **P < 0.01. (D-K) Histology examination showed obvious morphogenetic changes of the airway epithelial cells associated with CHIR 99021 treated lung tubes. Scale bars: D-G =100 μm; H-K = 20 μm.

    CHIR-99021 (CT99021) HCl purchased from Selleck.

产品安全说明书

GSK-3抑制剂选择性比较

生物活性

产品描述 CHIR-99021 (CT99021) HCl是CHIR-99021的盐酸盐, 是GSK-3α/β抑制剂,IC50为10 nM/6.7 nM。 其对GSK-3的选择性比对Cdc2和ERK2高500倍以上。
靶点
GSK-3β [1]
(Cell-free assay)
GSK-3α [1]
(Cell-free assay)
6.7 nM 10 nM
体外研究

CHIR-99021作用于GSK-3比作用于其最接近的同系物CDC2和ERK2,及其他蛋白激酶选择性高500倍。此外,CHIR-99021只与一组22种药理相关的受体微弱结合,且对一组23种非激酶的酶几乎没有抑制活性。CHIR-99021作用于表达胰岛素受体的CHO-IR细胞,诱导糖原合成酶(GS)激活,EC50为0.763 μM。[1]CHIR-99021(3 μM)作用于3T3-L1前脂肪细胞,除了模拟胰岛素的作用,抑制GSK-3,使胞内游离β-catenin增加1.9倍,模仿经典Wnt信号通路。在分化的前3天,CHIR-99021处理,抑制脂肪细胞分化,IC50为0.3 μM,通过抑制CCAAT/增强子结合蛋白α(C/EBPα)和过氧化物酶体增殖物激活受体γ(PPARγ)的诱导作用。[2] 不像LiCl和AR-A014418,CHIR-99021处理,即使在高浓度,不会降低INS-1E细胞活力。相反,CHIR-99021增加INS-1E细胞增殖,这种作用具有剂量依赖性,且显著抑制高糖和高棕榈酸诱导的INS-E细胞死亡,这种作用具有浓度依赖性。CHIR-99021浓度低至1 μM,处理离体大鼠胰岛,促进β细胞复制,5 μM CHIR-99021处理,使细胞复制增长2-3倍。[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
3T3-L1 MlL5SpVv[3Srb36gRZN{[Xl? MXuzJO69VQ>? MWW0JIg> Mlf6SG1UVw>? NXjx[3RTUW6qaXLpeJMheHKnYXTpdI9kgXSnIHTp[oZmemWwdHnheIlwdg>? NUPLSWRHOTJyNUWyNFA>
insulin receptor–expressing CHO-IR NEO5PGNHfW6ldHnvckBCe3OjeR?= MoToOVAxKG6P MoLQN|AhdWmw MYDEUXNQ M13DcWFkfGm4YYTld{BIdHmlb3flckBUgW62aHHz[UApT1Nr MX:xNlYxPjR7Nx?=
H4IIE NXXtZYFQTnWwY4Tpc44hSXO|YYm= NFnMdWkyOCEQvF2= NYnJc21DOjRiaB?= M2XrbGROW09? NH\hS3dT\We3bHH0[ZMh|rJvY3H0[Y5qdiCjY4Tpeol1gSCjbnSgWGlTTSClb370ZYlvcW6pIIDyc41wfGW{IHHjeIl3cXS7 NHzlfFkyPTN3MEG5OS=>
Oct4/Sox2/Klf4-infected MEFs NVXuPIpmTnWwY4Tpc44hSXO|YYm= M2\COVExKM7:TR?= NF\WcmszQCCm MWTEUXNQ M4nCU3Bzd22xdHXzJG1GTnNicnXwdo9oemGvbXnu[{BVemGwc3T1Z4VlKGK7IF;jeFQtKFOxeEKsJIFv\CCNbH[0 NGHMSnIyQTh|OUC1OS=>
Sca-1+ HPC NYrCV41HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M32xU|Ih|ryP MmX2OkBl MkjiSG1UVw>? MXHTfY5memerc4TpZ4FtdHlicILvcY91\XNiU3PhMVEsyqCKUFOgdJJwdGmoZYLheIlwdiCjbnSgZ49td267IH\vdo1ifGmxbjD0c4dmfGincjD3bZRpKEWJRh?= MXKyNVYzPDN2OB?=
HMC1.2 M{K4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXqzNEDPxE1? NVTVSmZIPzJiaB?= NY\vUXl1TE2VTx?= MmHlVoVlfWOnczDj[YxtKHO3co\peoFt MWWyNlA{QTNyMR?=
Endothelial cell(EC) MVjGeY5kfGmxbjDBd5NigQ>? M3LQcFMh|ryP MW\EUXNQ MVPQdo9ud3SnczDlcoRwfGinbHnhcEBk\WyuIDjFR{kh\GmoZnXy[Y51cWG2aX;u M37nSlIzODV{MEC2
PANC1 MkG2RZBweHSxc3nzJGF{e2G7 NGD3R5fDqDVizszN M1HUO|czKGh? MlvTSG1UVw>? M2Lhb3RzcWepZYLzJIFvKGGyb4D0c5Rq[yC{ZYPwc45{\Q>? MmfjNlIzODFzOE[=
INS-1E NHrHTW9HfW6ldHnvckBCe3OjeR?= M{Tqe|IvPSEQvF2= M1LkUFI1KGh? MXrEUXNQ MWrJcoR2[2W|IHGgdoVlfWO2aX;uJI9nKE6SMTDveoVz\XiycnXzd4lwdg>? NV3lSGs5OjJ2Mke3NFQ>
hiPSC-NPs Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEntSGY{6oDLzszN NVja[5ZNPzJiaB?= MoXwSG1UVw>? MXzJcoNz\WG|ZYOgZ4VtdCCycn;sbYZmemG2aX;uxsA> M3HHbFIzPjR{Nki3
platelets NWX1TZkzTnWwY4Tpc44hSXO|YYm= MUexNEDPxE1? NVPEeopPOTVibXnu NEXjSI9FVVOR M1P3b2lv[3KnYYPld{B1cHKxbXLpck1u\WSrYYTl[EBxdGG2ZXzleEBi\2e{ZXfheIlwdiCjbnSgRXRRKHOnY4LleIlwdg>? Mn7GNlMzOzl6N{e=
DN3 M4DQR2Z2dmO2aX;uJGF{e2G7 M{ToRlExKM7:TR?= NHuwcYU6PiCq NVLh[JZ{TE2VTx?= MXrJcoNz\WG|ZYOgZ4VtdCCmZY\lcI9xdWWwdDDhcoQheHKxbHnm[ZJifGmxbh?= M4fZNFI{PTJ4OUi5
embryonic stem cells (ESC) M3XzcGZ2dmO2aX;uJGF{e2G7 NY\2[2dDOyEEtV2= M2rrbVEyKGR? NYjofGU{TE2VTx?= M4LNc3Bzd22xdHXzJJNmdGZvcnXu[ZdidCCxZjDuZeOwfmVvdInw[UBud3W|ZTDlcYJzgW:waXOgd5RmdSClZXzsd{ApTVOFKR?= NXHpU5FmOjN6NEOzNVI>
H460 NHPqTJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHj3NZo2KML3TR?= NWPwRWc4OjRiaB?= NEG1SJVFVVOR NFHsWphRem:vb4Tld{Bk\WyuIIDyc4xq\mW{YYTpc44> MXKyOFM3PzZ6OB?=
H157 M17CSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILqSG02KML3TR?= NW\5dIljOjRiaB?= M1Wz[mROW09? NXKyeVRwWHKxbX;0[ZMh[2WubDDwdo9tcW[ncnH0bY9v NIL3TXgzPDN4N{[4PC=>
H460 M3vRZmFxd3C2b4Ppd{BCe3OjeR?= MlPpOUDDvU1? MYeyOEBp MoDQSG1UVw>? NGfZO2lCfHSnboXheIV{KGOnbHygZZBweHSxc3nz M3jrbVI1OzZ5Nki4
H157 Mn7CRZBweHSxc3nzJGF{e2G7 M3K0dlUhyrWP M{XpTVI1KGh? NEP1XHhFVVOR MonVSI9meyCwb4Sgd4lodmmoaXPhcpRtgSCjZn\lZ5Qh[XCxcITvd4l{ M3fSN|I1OzZ5Nki4
A549 NEjPXFBCeG:ydH;zbZMhSXO|YYm= M{DyXVUhyrWP NV;mR41FOjRiaB?= MnrSSG1UVw>? NHvLS5ZKdmO{ZXHz[ZMh[2WubDDhdI9xfG:|aYO= NWLY[HlzOjR|Nke2PFg>
Neural progenitor cells NHK5XVhHfW6ldHnvckBCe3OjeR?= M3X0d|Mh|ryP NGC0OGoyOCCm NVKxNYV1TE2VTx?= NIn5SGZKdmS3Y3XzJIdmdmW{YYTpc44hd2ZibnX1doFtKHC{b3flcol1d3JiY3XscJM> M1\BVlI1PjN6MEO0
ES-D3 M{\4[WN6fG:2b4jpZ{BCe3OjeR?= NHzYbFMyOMLizszN MkDFN{Bl NYLWe5BoTE2VTx?= NX30XW9qUW6mdXPld{Bud2SncnH0[UBkgXSxdH;4bYNqfHlid3n0bEBKSzVyIH;mJFQvQSEQvF2= NUTCdXVWOjR5N{mzOlU>
ES-CCE NXTTS|NDS3m2b4TvfIlkKEG|c3H5 Ml7LNVDDqM7:TR?= NHXXcJg{KGR? MYTEUXNQ MnTMTY5lfWOnczDtc4RmemG2ZTDjfZRwfG:6aXPpeJk> MVuyOFc4QTN4NR?=
ES-D3 MkXISpVv[3Srb36gRZN{[Xl? NIn5O4w2yqEQvF2= NFrZd2M{KGR? M2CzZ2ROW09? MVrTeJJwdmeueTDpcoR2[2W|IITo[UBi[3Srdnn0fUBw\iCZboSvZoV1[S2lYYTlcolvKHCjdHj3ZZk> NXv1eZBqOjR5N{mzOlU>
ES-CCE MX;GeY5kfGmxbjDBd5NigQ>? NWf5R4x6PcLizszN M{mxNlMh\A>? MUnEUXNQ NUToZoNjW3S{b37ncJkhcW6mdXPld{B1cGViYXP0bZZqfHlib3[gW451N2KndHGtZ4F1\W6rbjDwZZRpf2G7 NECyZY0zPDd5OUO2OS=>
SW982 MoG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwMkG0NVYh|ryP M136[3NCVkeHUh?=
GCT MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7hUlRKSzVyPUCuN|A3PzJizszN MYPTRW5ITVJ?
769-P NYG2dIoyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkKyTWM2OD1yLkW4OFk6KM7:TR?= NGfUW4pUSU6JRWK=
LOXIMVI MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDqNFBmUUN3ME2wMlU5QDN{IN88US=> MlXkV2FPT0WU
D-336MG NHrUU3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXaUpVKSzVyPUCuPFQ3OiEQvF2= NE\Me5dUSU6JRWK=
S-117 NUDtenN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnqNXVKSzVyPUCuPVIyOzFizszN NVz6dYViW0GQR1XS
D-247MG MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PzSGlEPTB;MD65OFg2OiEQvF2= M1TKW3NCVkeHUh?=
TYK-nu NGLkblVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkj1TWM2OD1zLkC3PVEzKM7:TR?= MXfTRW5ITVJ?
A498 NYixeJl6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU[zSJU3UUN3ME2xMlMxPDZ7IN88US=> NHzDO|ZUSU6JRWK=
BCPAP M4rkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXKTWM2OD1zLk[2PFk5KM7:TR?= NV21fYFQW0GQR1XS
KYSE-180 NIHrWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrCZ3VKSzVyPUGuO|I4QDhizszN MoXTV2FPT0WU
MIA-PaCa-2 NV;L[pNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nHdWlEPTB;MT63OVk4PyEQvF2= MYnTRW5ITVJ?
HCC1395 NEPnbYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWO1Wnl7UUN3ME2xMlc5Ojd|IN88US=> M1zKN3NCVkeHUh?=
RS4-11 Mo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D2RWlEPTB;MT65OVQyPSEQvF2= MoHnV2FPT0WU
NCI-H2122 Mn3WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NESwW5lKSzVyPUKuNlc3QDRizszN MVrTRW5ITVJ?
SNU-423 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nkOmlEPTB;Mj60PVc5PyEQvF2= NGnUUJRUSU6JRWK=
SK-LMS-1 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTJwNkSxNlgh|ryP MXvTRW5ITVJ?
RPMI-7951 NFLk[pVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWi2Zpo6UUN3ME2yMlcxOTl|IN88US=> MUPTRW5ITVJ?
COLO-829 NIW1TnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\4bHIyUUN3ME2yMlc3PTRizszN Mo\nV2FPT0WU
SCC-9 M3rYNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLG[2RKSzVyPUKuPVU1QDVizszN MXLTRW5ITVJ?
A704 NV\jWm03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjyPHFKSzVyPUOuNFgyOiEQvF2= Mkf6V2FPT0WU
HOP-62 Mn;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTNwM{[wOVQh|ryP NUPIUmRVW0GQR1XS
HCC1569 NH\SdZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTNwNEizNFUh|ryP NUKxXZJzW0GQR1XS
A172 M{GycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDlTWM2OD1|Lke1OFk5KM7:TR?= NEnJ[3NUSU6JRWK=
MOLT-16 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUP6RWJoUUN3ME2zMlg5PTV4IN88US=> NVi5N|hlW0GQR1XS
TE-15 NVLJbId2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTNwOUWzOFMh|ryP MVvTRW5ITVJ?
OE19 NX;IfZp4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTNwOU[0OVEh|ryP MluxV2FPT0WU
MHH-ES-1 M2ntOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{H6TmlEPTB;ND6wOFU1PSEQvF2= MWDTRW5ITVJ?
NKM-1 NGnjbWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPzT25KSzVyPUSuNVM6PzFizszN NW\2[29lW0GQR1XS
RCC10RGB NVnHSZBoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPqTWM2OD12LkK5OFc6KM7:TR?= MnSyV2FPT0WU
BxPC-3 NGj2SpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTRwN{CzPVEh|ryP M1m2WXNCVkeHUh?=
ALL-PO NYLYRm1lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTRwOEO4OVgh|ryP M1;aUnNCVkeHUh?=
SK-OV-3 MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX4TWM2OD12Lkm5N|Qh|ryP MmHmV2FPT0WU
SW1710 NFX1cVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\NemlEPTB;NT60NlQ2PiEQvF2= MoX0V2FPT0WU
NCI-H2452 NVnqZpV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfMWmJKSzVyPUWuOFU3OjhizszN NF;uR4NUSU6JRWK=
D-392MG MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTVwNEmxOFUh|ryP MYrTRW5ITVJ?
LB2518-MEL NWrETpJST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDaTWM2OD13LkeyOlI4KM7:TR?= NX3ZVIJYW0GQR1XS
BL-41 M4noS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGqwOJJKSzVyPUWuPFEzPjZizszN M2XyPHNCVkeHUh?=
WM-115 MofwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXPTWM2OD13LkixOVA6KM7:TR?= NIiwUYZUSU6JRWK=
SK-MEL-2 NEnEU3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HuOmlEPTB;Nj6zPFM1PCEQvF2= MnLnV2FPT0WU
CGTH-W-1 NX\2Z21RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEW5[JpKSzVyPU[uOFE4KM7:TR?= MV;TRW5ITVJ?
BB65-RCC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTZwNUOxPVUh|ryP NE\rRlJUSU6JRWK=
CAL-85-1 NWnFTJEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zGZmlEPTB;Nj62NFk{PiEQvF2= MWTTRW5ITVJ?
RT-112 NXHmd3pLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\vV4xJUUN3ME23MlE3PDV4IN88US=> NUi4eGF6W0GQR1XS
MC116 NUm5VllGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17wUGlEPTB;Nz6yPFY6OSEQvF2= NF;ESIhUSU6JRWK=
G-361 NFL0fXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTdwNE[1OlEh|ryP NUO1OmtsW0GQR1XS
SW1417 M33Nc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DTemlEPTB;Nz62OFU5PCEQvF2= M3HZdnNCVkeHUh?=
MV-4-11 NYHkd5ZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3uzbmlEPTB;OD61OFMxPCEQvF2= NUiwe2ZnW0GQR1XS
CAL-72 NFLmS2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXOxUHRbUUN3ME24Mlc3OTF|IN88US=> NVvjfY9RW0GQR1XS
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OPM-2 NYHaUnFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnYTWM2OD1zMkOuNVc3KM7:TR?= MXvTRW5ITVJ?
SW1463 NGixT5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\G[FVKSzVyPUGyOE4xPzdizszN NY\ERpVqW0GQR1XS
NCI-H2087 M4LGVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTF{ND6yPFMh|ryP MnjlV2FPT0WU
UMC-11 M37GSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTF{Nj6wN|gh|ryP MUXTRW5ITVJ?
EB-3 M3vpN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTTS|FVUUN3ME2xNlcvODF|IN88US=> MX;TRW5ITVJ?
HEC-1 Ml;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3Oc2dlUUN3ME2xNlkvOTl6IN88US=> M1\iS3NCVkeHUh?=
LU-99A M{XPb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fTRWlEPTB;MUK5Mlk{OSEQvF2= MmfJV2FPT0WU
VMRC-RCZ NHOxcoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH5TWM2OD1zM{CuN|c2KM7:TR?= NVX3N2JSW0GQR1XS
MFH-ino MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PKOGlEPTB;MUOxMlEyPCEQvF2= MkDpV2FPT0WU
HT-1080 NGiyUYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTF|Mj6yNFQh|ryP NVPWUXJzW0GQR1XS
CTB-1 Mo[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo[4TWM2OD1zM{KuPFk4KM7:TR?= NWTmXnVDW0GQR1XS
Capan-2 NHvmcI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{O5dGlEPTB;MUOzMlk4PSEQvF2= M1XHO3NCVkeHUh?=
BB30-HNC NWHqNHRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7rV|lKSzVyPUGzOE4yOTZizszN NV;rVoNnW0GQR1XS
CP50-MEL-B M3jjU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIG4VpFKSzVyPUGzOE4zKM7:TR?= MmDtV2FPT0WU
JEG-3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PKcGlEPTB;MUO0MlM2QSEQvF2= MW\TRW5ITVJ?
NCI-H1437 MoLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTF|ND61PUDPxE1? MXzTRW5ITVJ?
NOS-1 NV3x[pJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi1XmpKSzVyPUGzOE44PjVizszN NYridVFNW0GQR1XS
G-402 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT5b|JXUUN3ME2xN|UvOjl3IN88US=> Mnq1V2FPT0WU
OAW-42 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXHbI5nUUN3ME2xN|cvQDV4IN88US=> NYXIcJc5W0GQR1XS
Ca-Ski M37aWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfjXHBKSzVyPUGzPE45OzFizszN NYLob49[W0GQR1XS
BHT-101 MlLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq3W|dHUUN3ME2xOFAvOjB6IN88US=> MUnTRW5ITVJ?
OVCAR-4 NXnQ[HRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTF2MD63OFkh|ryP M1zIZXNCVkeHUh?=
Detroit562 MlzBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfEbGlKSzVyPUG0NU41PjZizszN MXPTRW5ITVJ?
OCI-AML2 MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF2MT61NFch|ryP MU\TRW5ITVJ?
OE33 M4L3PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTF2MT63PVgh|ryP MoPMV2FPT0WU
YKG-1 M4PGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLXR3VvUUN3ME2xOFIvQDh7IN88US=> MmnaV2FPT0WU
CCF-STTG1 M4H3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\hc2lEPTB;MUSzMlM{PCEQvF2= MmTxV2FPT0WU
NCI-H810 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrZbWRKSzVyPUG0N{43QDdizszN NXPUTYRQW0GQR1XS
SCC-25 M1rmeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXyXm9KSzVyPUG0OE4xODVizszN NHTaRoJUSU6JRWK=
HTC-C3 MluzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\LTWM2OD1zNEWuNFc2KM7:TR?= MnP5V2FPT0WU
G-401 Ml;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vYOGlEPTB;MUS1Mlg{PSEQvF2= M{Du[nNCVkeHUh?=
OMC-1 NW\hbY1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M32ySmlEPTB;MUS1Mlk3PyEQvF2= M4nR[nNCVkeHUh?=
LK-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXNcHJKSzVyPUG0O{4yPDNizszN MV\TRW5ITVJ?
SW13 MoqzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTF2Nz6yOVMh|ryP MVXTRW5ITVJ?
BB49-HNC NFLTSmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFKxfoFKSzVyPUG0O{41ODRizszN NVf0SJhpW0GQR1XS
DMS-114 NUjTUnpGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\Hb|hKSzVyPUG0O{41PDFizszN M2LiZnNCVkeHUh?=
GCIY M2LsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\PTWM2OD1zNEeuO|k4KM7:TR?= MWrTRW5ITVJ?
GAMG M1zafGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFL2b|dKSzVyPUG0PE4zPDdizszN NFjRdmVUSU6JRWK=
KYSE-520 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLuTWM2OD1zNEiuOVQh|ryP Ml\WV2FPT0WU
LB647-SCLC NWjZcZFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTF2OD61OlIh|ryP NVzybZAxW0GQR1XS
639-V MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHT4WoRKSzVyPUG0PE44ODVizszN M{XVO3NCVkeHUh?=
TE-9 NWfrb2ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTQb3lEUUN3ME2xOFkvPDR|IN88US=> M3yxS3NCVkeHUh?=
Caov-3 M4jYUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TKXWlEPTB;MUS5MlcyPCEQvF2= NF;mfmhUSU6JRWK=
L-540 NIHVZ2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MljPTWM2OD1zNEmuO|Uh|ryP NIDQO2dUSU6JRWK=
NCI-H748 M{GyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTF3MD6yNFkh|ryP MYjTRW5ITVJ?
GDM-1 NYG3WHk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rEXmlEPTB;MUWxMlE{PSEQvF2= NWH5d|RIW0GQR1XS
GAK NH;1UYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVr0SWR6UUN3ME2xOVEvOzd2IN88US=> NXH5TZg6W0GQR1XS
AsPC-1 NYrRXJBQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjaWGFqUUN3ME2xOVIvPzZ2IN88US=> MoDIV2FPT0WU
MDA-MB-361 M{S4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jmbWlEPTB;MUWzMlE3PCEQvF2= MYLTRW5ITVJ?
TT NYLTS3MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHm5OYNKSzVyPUG1N{41QSEQvF2= Mny2V2FPT0WU
Calu-1 NEX2bVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTF3ND6wNFMh|ryP MV7TRW5ITVJ?
RERF-LC-MS M3zocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O4S2lEPTB;MUW0Mlc4OiEQvF2= MXXTRW5ITVJ?
DK-MG NUO1[|RHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGT0RpVKSzVyPUG1OU4yQDNizszN Mn\jV2FPT0WU
CAL-120 M4T2N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vYdmlEPTB;MUW1MlgzOSEQvF2= MXjTRW5ITVJ?
HCC1419 M3PMcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTF3Nj6wO|ch|ryP NX:1dXpmW0GQR1XS
DG-75 M13FZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTwSGtxUUN3ME2xOVYvPjl2IN88US=> NFjxdmdUSU6JRWK=
HCC38 M{P2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUX4epZiUUN3ME2xOVcvOzZ7IN88US=> M{Sxb3NCVkeHUh?=
HCC70 NVTMeGsyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M334XGlEPTB;MUW5MlI1OiEQvF2= NHHPTJJUSU6JRWK=
ES4 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;VV2lEPTB;MUW5MlM6PiEQvF2= MULTRW5ITVJ?
NCI-H2052 NVzaSVByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzrTWM2OD1zNUmuOVg{KM7:TR?= MWXTRW5ITVJ?
EFO-27 MmK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP6Ro04UUN3ME2xOlAvPTh2IN88US=> Mo\WV2FPT0WU
CAL-62 NFTQUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXPTWM2OD1zNkKuOlE{KM7:TR?= NYDUTXY2W0GQR1XS
CHP-212 M3Hkdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnaU2c5UUN3ME2xOlMvPjJ4IN88US=> NYHTWIY2W0GQR1XS
AU565 M1mwbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnJZm4{UUN3ME2xOlMvPjRizszN NUPjbnhCW0GQR1XS
Ca9-22 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DweWlEPTB;MU[0MlMzOSEQvF2= MX;TRW5ITVJ?
EFO-21 NIHVUXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3i5VGlEPTB;MU[1MlQ2KM7:TR?= MnrEV2FPT0WU
KINGS-1 NYLBe|NyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfhNG9pUUN3ME2xOlcvOzV2IN88US=> MmDPV2FPT0WU
JVM-2 NFi2SZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkL2TWM2OD1zNkeuOFUyKM7:TR?= NWDIOGZXW0GQR1XS
OVCAR-5 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLrVJBKSzVyPUG2PE4{ODlizszN MY\TRW5ITVJ?
Calu-3 MoLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnFUXZsUUN3ME2xOlgvOzFzIN88US=> NWjibYpLW0GQR1XS
CP66-MEL NUDVdYU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTF4OD60NVUh|ryP MYPTRW5ITVJ?
KYSE-150 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTF4OT62N|Yh|ryP MU\TRW5ITVJ?
Daoy MlXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTF4OT64PVEh|ryP M{\NdXNCVkeHUh?=
HUTU-80 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDKTIc{UUN3ME2xO|EvODN{IN88US=> NIfIZ5VUSU6JRWK=
SW620 NXXNVnlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTF5MT61N|Uh|ryP NGP6OmlUSU6JRWK=
HuO-3N1 MlW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP2dIdrUUN3ME2xO|IvOjd|IN88US=> M2\kOHNCVkeHUh?=
HH NUnXTHlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHFTWM2OD1zN{OuPFQ5KM7:TR?= NXXNUVA3W0GQR1XS
ME-180 NWLOXpN7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TwWWlEPTB;MUe0MlAyPiEQvF2= M123[nNCVkeHUh?=
SW756 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTF5ND64OlMh|ryP NVLzOpRMW0GQR1XS
LNCaP-Clone-FGC NYToemExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPJTYVnUUN3ME2xO|UvQDZzIN88US=> M1LlPHNCVkeHUh?=
YT NHu0WWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3qZ|RVUUN3ME2xO|YvOzl7IN88US=> Mmj2V2FPT0WU
EW-3 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7JR2NKSzVyPUG3Ok42PTVizszN MYjTRW5ITVJ?
COLO-741 MkLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHVTWM2OD1zN{euOVYyKM7:TR?= MofQV2FPT0WU
SK-NEP-1 NEHGWIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHGU|ZKSzVyPUG3O{45ODZizszN MUXTRW5ITVJ?
NB10 NIrCdmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\xcWlEPTB;MUe3Mlg1PiEQvF2= NFXJ[3dUSU6JRWK=
SF126 NWeyR5lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zw[WlEPTB;MUe5MlQ{OiEQvF2= MnezV2FPT0WU
NCI-H522 NWDBWpZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1S2R2lEPTB;MUixMlA2QSEQvF2= NIPCcJNUSU6JRWK=
PSN1 NFX1UGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;COY5ZUUN3ME2xPFEvPjZizszN NVzETG1KW0GQR1XS
GI-ME-N NWLxOo9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NISxVlZKSzVyPUG4NU43PzJizszN NVX6UGVKW0GQR1XS
SBC-5 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfENVNqUUN3ME2xPFEvQTN2IN88US=> M4C5eXNCVkeHUh?=
ONS-76 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTF6Mj6zPFch|ryP MVvTRW5ITVJ?
LOUCY M{G0Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LTemlEPTB;MUiyMlY5QCEQvF2= NV\CSZlDW0GQR1XS
SN12C M{\xUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTrTWM2OD1zOEKuPFI6KM7:TR?= NFzJTVlUSU6JRWK=
A427 NVjuVHk1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHY[2xwUUN3ME2xPFQvPjNzIN88US=> NEjYOVZUSU6JRWK=
DOK NHj2[XFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;lUINKSzVyPUG4OE43PDNizszN MoO0V2FPT0WU
MDA-MB-415 M1y2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\aTWM2OD1zOESuOlUyKM7:TR?= M4fJU3NCVkeHUh?=
MRK-nu-1 NFHTWpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHixe49KSzVyPUG4OE46PzJizszN NHm5UnRUSU6JRWK=
LB2241-RCC M{LjOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW3V5lKSzVyPUG4OU4yPDVizszN M4TkTHNCVkeHUh?=
NCI-H1563 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\BbmlEPTB;MUi1MlIxQSEQvF2= M{j1[nNCVkeHUh?=
MDA-MB-453 Mlj4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\kfWdPUUN3ME2xPFYvQTRzIN88US=> MUDTRW5ITVJ?
MONO-MAC-6 M3\sNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\4bWNKSzVyPUG4O{4{QTJizszN NGCzUFZUSU6JRWK=
CAPAN-1 NUPzOoFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTF6Nz60OVMh|ryP NWPob4h[W0GQR1XS
SK-LU-1 NWPtXIU{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3LeZl5UUN3ME2xPFgvPDJ6IN88US=> M1n2SHNCVkeHUh?=
NCI-H1299 NGrSRnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jyR2lEPTB;MUi4MlcyQSEQvF2= MYnTRW5ITVJ?
KG-1 NGnoRWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrDT|lKSzVyPUG4PU44QThizszN MkPRV2FPT0WU
ETK-1 MlHuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\RTWM2OD1zOUCuNVgyKM7:TR?= NXfM[YUxW0GQR1XS
NCI-H838 MlfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLSUpY{UUN3ME2xPVAvOzRizszN MnfJV2FPT0WU
HCE-4 M1TqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTF7MD65PVIh|ryP MXXTRW5ITVJ?
A2780 NGGwbpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF23R45KSzVyPUG5Nk45QTFizszN NYjmUlhHW0GQR1XS
COLO-668 M3;PSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTF7Mz6xOVch|ryP MV3TRW5ITVJ?
HGC-27 MnGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInCRo1KSzVyPUG5OU42OzhizszN MYnTRW5ITVJ?
SW1088 NVrId|hFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;Pe2xXUUN3ME2xPVUvPjd5IN88US=> NEXEc4ZUSU6JRWK=
KOSC-2 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\DTWM2OD1zOUWuPFE5KM7:TR?= MUfTRW5ITVJ?
TE-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTrOZlUUUN3ME2xPVYvOjZizszN NV\icnk4W0GQR1XS
SW780 Ml7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnhR|lKSzVyPUG5Ok44OzRizszN MnvNV2FPT0WU
22RV1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDrTWM2OD1zOUeuOFI1KM7:TR?= NUXhW5Z7W0GQR1XS
IA-LM NXTDb|E2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUK2c25qUUN3ME2xPVcvQDJ{IN88US=> MYHTRW5ITVJ?
TE-5 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnFe5ZWUUN3ME2xPVgvODN|IN88US=> M{TRSXNCVkeHUh?=
JVM-3 M3zUfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV6yT3dJUUN3ME2xPVgvPDF7IN88US=> NUCxZnVYW0GQR1XS
HT55 NHzn[ZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;Z[VNVUUN3ME2xPVkvOTl{IN88US=> MnHqV2FPT0WU
QIMR-WIL M2naZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnybnVKSzVyPUKwNE4yOTZizszN M1PBOnNCVkeHUh?=
SJRH30 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTJyMD61NVUh|ryP M2XLSnNCVkeHUh?=
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OCUB-M M{\qPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT2TWM2OD1|MkOuOFM1KM7:TR?= NVyxe4sxW0GQR1XS
HCC1954 NYOySnFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXheFlKSzVyPUOyN{42QDJizszN MmHsV2FPT0WU
SK-MEL-24 Ml7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTN{ND6xNVEh|ryP MmG0V2FPT0WU
NTERA-S-cl-D1 NETTe2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnSfIRKSzVyPUOyOk41QDlizszN NX;NPHE4W0GQR1XS
SK-MEL-30 Ml7qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTN{Nj63N|gh|ryP M1HkSXNCVkeHUh?=
LS-123 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF30Z|hKSzVyPUOyPE4yPjRizszN MkXwV2FPT0WU
SF268 NILVfFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXXZVBKSzVyPUOzNE4zPjVizszN NHXGUYVUSU6JRWK=
BT-474 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3YeJU{UUN3ME2zN|IvPDF6IN88US=> M33s[3NCVkeHUh?=
NCI-H1522 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPqVXFKSzVyPUOzOE4{OzlizszN MnPyV2FPT0WU
LC-2-ad MnXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\zVVdKSzVyPUOzOk42QTFizszN M1jUW3NCVkeHUh?=
LAN-6 MnLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTN|Nj65O|ch|ryP MmfrV2FPT0WU
ARH-77 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkj4TWM2OD1|M{euN|Ih|ryP NILnO5lUSU6JRWK=
HuO9 M4WwSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjHTWM2OD1|M{euOFch|ryP NX\We|ZqW0GQR1XS
MLMA NFHqWHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULFPHBLUUN3ME2zN|gvOTV3IN88US=> MWPTRW5ITVJ?
Raji NUTwN|hXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYWyWHM5UUN3ME2zN|gvOzhizszN MkLRV2FPT0WU
GT3TKB MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTN|OD60NVIh|ryP MVnTRW5ITVJ?
NCI-H441 MormS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rLOWlEPTB;M{SxMlQyQCEQvF2= NUi3[nJOW0GQR1XS
NCI-H2030 Ml3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HzeGlEPTB;M{SxMlYxQSEQvF2= NF61dnRUSU6JRWK=
VM-CUB-1 M1TPXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nzVGlEPTB;M{SyMlY{PiEQvF2= NI[3cJhUSU6JRWK=
KP-4 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2KwOWlEPTB;M{SzMlc{OyEQvF2= MkHSV2FPT0WU
PF-382 MoHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDUXm43UUN3ME2zOFQvPDJ{IN88US=> MmPDV2FPT0WU
NB13 M37veGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPaNFFXUUN3ME2zOFUvPThizszN M{PlbHNCVkeHUh?=
D-502MG M2fIT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rKOGlEPTB;M{S1MlgyOiEQvF2= NHTWbY9USU6JRWK=
CAL-54 NY\OXnl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[0ZWRYUUN3ME2zOFUvQDd7IN88US=> M3rod3NCVkeHUh?=
DOHH-2 MmWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkC4TWM2OD1|NE[uOlUh|ryP NUnoVI5QW0GQR1XS
SK-PN-DW M4HDbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\tTmZSUUN3ME2zOFcvPDJ4IN88US=> NEHjdm5USU6JRWK=
NCI-H720 NXnjS4s2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPkVZBKSzVyPUO0PU45PDZizszN NGW2e3BUSU6JRWK=
SW1990 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nQWGlEPTB;M{WxMlI5KM7:TR?= M120enNCVkeHUh?=
NCI-H2196 Mnj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTN3Mj62NlQh|ryP MXzTRW5ITVJ?
P30-OHK M4HkPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTN3Mz6wOlMh|ryP NYf3Roo2W0GQR1XS
NCI-H358 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XOfmlEPTB;M{W1MlM2PiEQvF2= M{jwO3NCVkeHUh?=
CW-2 M{LWemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTN3Nj61Nlkh|ryP MnnvV2FPT0WU
COLO-678 Mn3ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHKXHRRUUN3ME2zOVcvQDZ|IN88US=> NHTzWoFUSU6JRWK=
NCI-H2126 MnHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PaUGlEPTB;M{W4MlUzOSEQvF2= Mn3nV2FPT0WU
DMS-53 M3e3[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXMTWM2OD1|NUiuO|EyKM7:TR?= MoSwV2FPT0WU
NCI-H1838 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTN3OT65PFch|ryP MkXRV2FPT0WU
SJSA-1 M4fyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4P6[2lEPTB;M{[wMlk{QSEQvF2= NF\ESmpUSU6JRWK=
ChaGo-K-1 M{flUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljOTWM2OD1|NkOuPVI1KM7:TR?= MWHTRW5ITVJ?
IST-SL2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnGzTWM2OD1|N{KuPVI3KM7:TR?= MmfvV2FPT0WU
U-266 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLFTmVKSzVyPUO3N{4yOzJizszN M1i1SHNCVkeHUh?=
P31-FUJ NUC0Z|ZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWriOHN1UUN3ME2zO|YvQTZ2IN88US=> MX7TRW5ITVJ?
HCC2157 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTN5OD6xOlEh|ryP NFHzR2ZUSU6JRWK=
COR-L88 NX\QRZNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnWfYVKSzVyPUO4N{43PzdizszN MUHTRW5ITVJ?
NCI-H596 NXfjZY9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXZTWM2OD1|OEWuN|Qh|ryP NXzU[2dKW0GQR1XS
GOTO NGX6T4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\Je2lEPTB;M{mwMlY1OSEQvF2= M{Hze3NCVkeHUh?=
NCI-H719 NI\sVlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzhTWM2OD1|OUGuPFk{KM7:TR?= M{exbXNCVkeHUh?=
MN-60 MlG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\FTmlEPTB;M{mzMlk1QCEQvF2= MlLtV2FPT0WU
IST-SL1 NVzXfpRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlWyTWM2OD1|OUSuOFA3KM7:TR?= NXXjWGNtW0GQR1XS
TE-6 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXQTWM2OD1|OUeuNlU1KM7:TR?= MoH0V2FPT0WU
SW962 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\DTWM2OD1|OUiuOlkh|ryP NEDpTItUSU6JRWK=
FADU MkDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTRyMz6wPFMh|ryP NWrNNIgzW0GQR1XS
ECC4 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULmb5NjUUN3ME20NFgvPDV6IN88US=> MWPTRW5ITVJ?
MES-SA MnLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTRyOT65PEDPxE1? NHPZXZNUSU6JRWK=
NCI-H716 M3XkeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInLUYVKSzVyPUSxNE4xPzVizszN MWLTRW5ITVJ?
GR-ST NYfQSWtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTRzMD60PVch|ryP M1nFXHNCVkeHUh?=
KY821 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTsOolGUUN3ME20NVQvODh4IN88US=> NHXXO|BUSU6JRWK=
NCI-H2141 M3j2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4f6V2lEPTB;NEK0MlM5QCEQvF2= Mk[3V2FPT0WU
MDA-MB-134-VI MmTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTR|MT6wN|Mh|ryP MV3TRW5ITVJ?
RH-1 MoqyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULLTm1VUUN3ME20N|UvODlizszN MlfGV2FPT0WU
AM-38 MlThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfiTWM2OD12M{iuOVQh|ryP MV\TRW5ITVJ?
BL-70 M{Dwcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTR|OT60Nlkh|ryP NH3BcoJUSU6JRWK=
COLO-684 MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP2[YZKSzVyPUS0PE45QDhizszN NETYe|dUSU6JRWK=
DMS-79 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX6xRmNRUUN3ME20OFkvPjhizszN MVjTRW5ITVJ?
EW-1 MlLTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTR3Mj64PFgh|ryP MXPTRW5ITVJ?
MS-1 Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLScIFKSzVyPUS1OE4{QDVizszN NUjMOZhwW0GQR1XS
A4-Fuk NVj1XmZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTR3ND61NFch|ryP NXnwb|dQW0GQR1XS
TALL-1 M{PMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYD6NJVQUUN3ME20OVUvOjl5IN88US=> M4T1XnNCVkeHUh?=
SCLC-21H Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG4TWM2OD12NUWuOlk6KM7:TR?= NXzaVIxjW0GQR1XS
KMS-12-PE M3Ho[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTR3Nj64NlIh|ryP M{DJOHNCVkeHUh?=
TE-441-T NHz4eWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf1XFRKSzVyPUS1O{4yQDZizszN M1jj[3NCVkeHUh?=
A3-KAW M4HOcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjiSWpKSzVyPUS2NE45PDFizszN NG\vT5VUSU6JRWK=
NCI-H1092 NIDLO|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGyfotrUUN3ME20OlMvQTR|IN88US=> NFPrPHlUSU6JRWK=
COR-L279 MlK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33IWmlEPTB;NE[0Mlg1PyEQvF2= M{DMc3NCVkeHUh?=
NCI-SNU-5 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTR5Mj6yPEDPxE1? MlPLV2FPT0WU
JAR Mk\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTR5ND63PFgh|ryP Mm\rV2FPT0WU
NCI-H446 MkC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[xW4RKSzVyPUS3O{4xQCEQvF2= M{HUU3NCVkeHUh?=
HDLM-2 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2i1UGlEPTB;NEiwMlg3QSEQvF2= MmPlV2FPT0WU
D-283MED M1jQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVe1Z3pOUUN3ME20PFgvQTJ2IN88US=> Mn\sV2FPT0WU
NCI-H1395 NFzZRVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTR6OT6wNFQh|ryP MWXTRW5ITVJ?
RPMI-6666 NFf2OGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIKyRYVKSzVyPUS5NU4{QThizszN NFzNc5NUSU6JRWK=
CPC-N MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELtUWpKSzVyPUWwNk4xPjNizszN MnT1V2FPT0WU
EC-GI-10 NF;FW3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI[xNlVKSzVyPUWwNk4yPjlizszN NV\wTndNW0GQR1XS
CA46 NGPEelVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nSS2lEPTB;NUC0MlQxPyEQvF2= MlHvV2FPT0WU
EHEB NFf4R3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrLTWM2OD13MEeuNlA5KM7:TR?= NXrCSFFpW0GQR1XS
RPMI-8402 M{HtfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTKW2NjUUN3ME21NVAvODJzIN88US=> NEn5OHNUSU6JRWK=
DU-4475 NGnq[GNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTVzMT6xNFEh|ryP M4q5e3NCVkeHUh?=
P12-ICHIKAWA NEHPUFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfqOHlKSzVyPUWxNU41OTZizszN M13mbHNCVkeHUh?=
NCI-H1694 NH;xXYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W0bmlEPTB;NUGyMlQ{QSEQvF2= NUPrOWt5W0GQR1XS
NCI-H2171 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFW4[GZKSzVyPUWxNk44ODVizszN Mo\hV2FPT0WU
Mo-T MlL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnYdpNKSzVyPUWxOU4yOTZizszN MkW4V2FPT0WU
HL-60 Ml\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTV{Mj65NlQh|ryP MUHTRW5ITVJ?
NCI-H1436 NIjwZo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTV{Mz6wOlQh|ryP M1;tWnNCVkeHUh?=
NCI-H510A MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnW2TWM2OD13MkSuOlk3KM7:TR?= MoflV2FPT0WU
NCI-H2081 MmPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfUTWM2OD13MkWuOVE{KM7:TR?= NX3QdVQ1W0GQR1XS
NB5 NWPUbII6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli4TWM2OD13Mk[uOFMh|ryP M3Lu[HNCVkeHUh?=
NCI-H2227 NIHyfm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\WdYhuUUN3ME21N|AvOjV2IN88US=> NFXITI9USU6JRWK=
HSC-4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLKS|NKSzVyPUWzPU4zQTNizszN MXvTRW5ITVJ?
RL NGHm[WlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDJbXloUUN3ME21OFIvPDR{IN88US=> M3nUbHNCVkeHUh?=
EVSA-T NUnLZpBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPEO2NKSzVyPUW0N{43QDRizszN M3rzSnNCVkeHUh?=
NCI-H889 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;YTWM2OD13NEeuNlMh|ryP NIXT[YpUSU6JRWK=
COLO-320-HSR NGSxVpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTV3MT6zOUDPxE1? NWLrNlJpW0GQR1XS
EW-11 NHzFU2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTV3Mj6zPVkh|ryP M2\UTHNCVkeHUh?=
UACC-812 MkDSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO1cnJKSzVyPUW1PU4{QTFizszN M3i3dnNCVkeHUh?=
CAL-148 NIX3[XdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rRN2lEPTB;NU[1MlA5QSEQvF2= MYTTRW5ITVJ?
K052 NEPhO4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXf4UoQ6UUN3ME21O|kvOjF|IN88US=> MVrTRW5ITVJ?
L-428 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTZyMD62O|Eh|ryP MUjTRW5ITVJ?
LP-1 NYr2O5d{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELnfpZKSzVyPU[wN{42QDdizszN MULTRW5ITVJ?
ML-2 NXqyRnhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTZyNj61O|kh|ryP MYLTRW5ITVJ?
KARPAS-45 M17uPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17ENWlEPTB;NkG4MlIzOSEQvF2= MXHTRW5ITVJ?
HT MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPDTWM2OD14MkKuO|g2KM7:TR?= Mnz6V2FPT0WU
NCI-H226 MlK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTZ{OD6zOVMh|ryP M13rXXNCVkeHUh?=
L-363 M1rIW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jl[WlEPTB;NkS4MlA3PCEQvF2= NYSwS5BPW0GQR1XS
IM-9 NGXLdYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTZ3MT61OFEh|ryP NED3SVdUSU6JRWK=
TUR NYLCT25nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLQTWM2OD14N{GuN|IzKM7:TR?= M{ThSnNCVkeHUh?=
NCI-SNU-16 NYrZbHlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTZ6MD60OlIh|ryP NGPuXXRUSU6JRWK=
NCI-SNU-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVf5fVlLUUN3ME22PVAvOTd{IN88US=> NXe2TlRnW0GQR1XS
U-87-MG MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXrfpdKSzVyPU[5OE42QDVizszN NHjYW49USU6JRWK=
KM-H2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfKVIJqUUN3ME22PVkvODV7IN88US=> MVLTRW5ITVJ?
DEL NWfWU|M3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[3TGlEPTB;N{CwMlg{QCEQvF2= NYfnUGJtW0GQR1XS
KARPAS-422 M3XEZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fFVGlEPTB;N{i5MlMyPSEQvF2= MkXxV2FPT0WU
BC-3 NWDsVpM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nLV2lEPTB;OEC1MlIxOyEQvF2= M2HiOXNCVkeHUh?=
NCI-H1155 MlPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PDUWlEPTB;OEG4MlA2QSEQvF2= NXLCWXp1W0GQR1XS
NCI-H1581 MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{e0VmlEPTB;OUCwMlI{OSEQvF2= M4\QfXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

体内研究 CHIR-99021按30 mg/kg 剂量口服处理患2型糖尿病的啮齿类动物模型,增强葡萄糖代谢,处理3-4小时后,最大血浆葡萄糖减少近150 mg/dl,而血浆胰岛素保持或低于对照水平。CHIR-99021按16 或 48 mg/kg剂量口服给药ZDF大鼠,1小时后,再口服葡萄糖,显著改善糖耐量,16 mg/kg 和 48 mg/kg处理组的血浆葡萄糖分别减少14%和33%,较高剂量CHIR-99021处理,再口服葡萄糖,还可以降低高血糖。[1]CHIR-99021处理移植小鼠或人造血干细胞(HSC)的受体小鼠,显著增强造血重建功能,说明GSK-3是一种特异性的HSC活性调节剂。[4]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

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无细胞激酶实验:

聚丙烯96孔板中每孔充满了含27 nM GSK-3α 或 29 nM GSK-3β, 和 0.5 μM 生物素-CREB 肽底物的300 μL 缓冲液 (50 mM Tris HCl, 10 mM MgCl2, 1 mM EGTA, 1 mM 二硫苏糖醇, 25 mM β-glycerophosphate, 1 mM NaF, 0.01% BSA, pH 7.5) 。各种浓度CHIR-99021加入3.5 μL DMSO中,随后加入50 μL ATP储存液,使所有无细胞实验中ATP终浓度为1 μM。温育后,100 μL等分试样按一式三份转移至每孔含100 μL 50 μM ATP和 20 mM EDTA的Combiplate 8孔板中。1小时后,使用用PBS将孔洗涤5次,填充200 μL闪烁液,密封,放置30分钟后,然后在闪烁计数器中计数。所有步骤在室温下进行。
细胞实验:

[3]

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  • Cell lines: INS-1E
  • Concentrations: 溶于DMSO, 终浓度为20 μM
  • Incubation Time: 1, 或 4 天
  • Method:

    细胞在饥饿培养基(只含5mM葡萄糖,1%胎牛血清)中维持24小时。然后使用不同浓度的CHIR-99021处理细胞的1天或4天。通过使用CyQuant染料进行细胞DNA染色,测量细胞数,当结合DNA就会发出荧光。温育30分钟后,使用FLUOstar Optima酶标仪测量荧光。通过BrdUrd掺入法测定细胞复制。最后4小时,BrdUrd标记溶液加入到培养基中,然后使用FixDenat溶液固定细胞,与单克隆anti-BrdUrd-POD抗体温育。每孔加入底物溶液后,在微孔板发光检测仪上使用Analyst HT检测系统测量光发射。


    (Only for Reference)
动物实验:

[1]

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  • Animal Models: 雌性db/db小鼠或雄性2型糖尿病ZDF大鼠
  • Formulation: 在20mM柠檬酸盐缓冲的15%Captisol中配制成溶液,或在0.5%羧甲基纤维素中配制成悬浮液
  • Dosages: ~48 mg/kg
  • Administration: 口服处理
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 93 mg/mL (185.33 mM)
Ethanol 2 mg/mL (3.98 mM)
Water Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
5% DMSO+30% PEG 300+ddH2O
24mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 501.8
化学式

C22H18Cl2N8.HCl

CAS号 1797989-42-4
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

常见问题及建议解决方法

  • 问题 1:

    I recently purchased CHIR 99021 to inject mice intraperitoneally. The data sheet says using 10% captisol for in vivo use. Is it for IP injection? Or do you have other solutions to suggest to use for in vivo IP injection of CHIR 99021?

  • 回答:

    The formulation of 15% Captisol is for oral gavage, and S2924 CHIR-99021 (CT99021) HCl in it is a suspension. S2924 CHIR-99021 (CT99021) HCl can be dissolved in 5% DMSO+30% PEG 300+ddH2O at 24mg/ml as a clear solution for IP injection.

  • 问题 2:

    How about the half-life of this compound? If it is necessary for daily treatment when the compound is used in long-term experiment?

  • 回答:

    Please change the culture medium each day to add the new comound in it if the duration is more than 72h.

  • 问题 3:

    What is the difference between S2924 and S1263? Which one is better for differentiation?

  • 回答:

    S1263 is the free base format of Chir-99021, while S2924 is the HCl salt format. They have the same biological activity but are slightly different in solubility.

GSK-3 Signaling Pathway Map

GSK-3 Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID