PF-562271

目录号:S2890

PF-562271 Chemical Structure

Molecular Weight(MW): 507.49

PF-562271是一种有效的,ATP竞争性的,可逆的FAK抑制剂,无细胞试验中IC50为1.5 nM,作用于FAK比作用于Pyk2选择性高10倍左右,比作用于其他蛋白激酶(除了一些CDKs)选择性高100倍以上。

规格 价格 库存 购买数量  
RMB 2862.96 现货
RMB 1392.84 现货
RMB 2194.82 现货
RMB 5469.68 现货
RMB 7967.47 现货
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客户使用该产品的4个实验数据:

  • (F,G) The migration and invasion ability of 5637 and T24 cells transfected with PF-562271 and WT-METTL13 was examined. The number of cells was quantified and is shown in a column graph.

    Sci Rep, 2016, 6:19261. PF-562271 purchased from Selleck.

    D-F. T47D cells plated as in A were treated with vehicle (−) or the FAK Y397 inhibitor, PF-562271 (+), for 1 h prior to ± PRL (4 nM) for 15 min (representative immunoblots).

    Oncotarget, 2016, 7(30):48093-48106. PF-562271 purchased from Selleck.

  • OVISE cells were incubated for 24 hr at the indicated concentrations of the FAK inhibitors. Immunoblots were performed to assess inhibition of auto-phosphorylation by the FAK inhibitors.

    PLoS One 2014 9(2), e88587. PF-562271 purchased from Selleck.

    VEGF and P450 enzyme production in response to FAK or Src inhibitors. MCF10A cells were cultured in LD collagen gels ?vehicle control (V), 10 uM PF-562271 FAK ATP inhibitor (PF) or Src inhibitor PP2 for 24 h. Cells were also lysed and examined for CYP1A1 or CYP4B1 by immunoblot (B and C) and densitometry (D and E). VEGF data are displayed as the mean normalized to the vehicle control, N = 6, 盨EM, *p < 0.003 vs control (A). P450 data are displayed as the mean relative to GAPDH and normalized to the control. N > 4, ±SEM, *p < 0.05 vs respective control (D and E).

    Environ Toxicol Pharmacol 2014 39(1), 114-124. PF-562271 purchased from Selleck.

产品安全说明书

FAK抑制剂选择性比较

生物活性

产品描述 PF-562271是一种有效的,ATP竞争性的,可逆的FAK抑制剂,无细胞试验中IC50为1.5 nM,作用于FAK比作用于Pyk2选择性高10倍左右,比作用于其他蛋白激酶(除了一些CDKs)选择性高100倍以上。
靶点
FAK [1]
(Cell-free assay)
PYK2 [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
CDK3/CyclinE [1]
(Cell-free assay)
CDK1/CyclinB [1]
(Cell-free assay)
1.5 nM 13 nM 30 nM 47 nM 58 nM
体外研究

PF-562271会结合到ATP与FAK结合的部位,在激酶铰链区形成抑制剂与主链原子之间的两种氢键。PF-562271在测量FAK磷酸化可诱导的基于细胞的分析中效果很好,IC50为5 nM。PF-562271 (3.3 μM)导致PC3-M细胞周期停滞在G1期[1]。在鸡胚绒毛尿囊膜实验中PF-562271 (1nM)阻断bFGF刺激的血管生成。 PF-262271 强有效的阻断血管生长但对血管渗漏没有明显影响[2]。PF-562271 (250 nM)可以完全抑制整体A431 细胞侵入胶原蛋白中[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIm4UYhKSzVyPUCuNlc3PiEQvF2= NXqyOVNDW0GQR1XS
SW982 M3XjfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXvTWM2OD1yLkOyPFIh|ryP M2TMPXNCVkeHUh?=
KM12 MoDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwM{i1OVch|ryP MWjTRW5ITVJ?
COLO-205 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwNEi2OVgh|ryP NW\JUZd6W0GQR1XS
COLO-829 M1rReGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfmXGVFUUN3ME2wMlc2OTd4IN88US=> M1u2W3NCVkeHUh?=
MG-63 M4DRVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXkVnBiUUN3ME2wMlgxPjN5IN88US=> NI\Od4RUSU6JRWK=
IGROV-1 NFj6S3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXYTWM2OD1yLkixNFM5KM7:TR?= NH30RXhUSU6JRWK=
NCI-H650 M3\vbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvXSXlKSzVyPUCuPFMyPTRizszN MVzTRW5ITVJ?
RT-112 NHS4OZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfSTWM2OD1yLkm4OFYh|ryP MknBV2FPT0WU
BCPAP NVHQcYZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELSfpVKSzVyPUGuNFEzQDhizszN NWfZUGtlW0GQR1XS
ALL-PO NHXm[IlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLwSHdKSzVyPUGuNFE2QDRizszN M{nYd3NCVkeHUh?=
KYSE-270 NYfJT|ZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHwWm86UUN3ME2xMlA1PzF2IN88US=> NX;BO3pqW0GQR1XS
8305C NYq0OIlIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTFwMEm5NFQh|ryP NWDUPVdMW0GQR1XS
NCI-H810 M2HuXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn20TWM2OD1zLkGwO|c3KM7:TR?= MVLTRW5ITVJ?
CAL-33 NXTkXWxUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTFwMUK5N|gh|ryP NVjWcpZ[W0GQR1XS
AN3-CA MnewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFwMkG4Olch|ryP NIDhV3BUSU6JRWK=
NKM-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\udXVKSzVyPUGuNlc2ODZizszN M1XST3NCVkeHUh?=
BPH-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTFwMki3OlYh|ryP NG\sT|JUSU6JRWK=
MES-SA M17ocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvoTWM2OD1zLkOwOlgzKM7:TR?= MUDTRW5ITVJ?
CAL-62 MnzlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFwM{G5NFkh|ryP NF2xS3dUSU6JRWK=
Detroit562 MlG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrZWWxKSzVyPUGuN|UzOjJizszN NYKyT2hxW0GQR1XS
KYSE-150 M3rx[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnmTWM2OD1zLkO1NlM3KM7:TR?= MnTnV2FPT0WU
SK-UT-1 NXjkTnVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLNTY9KSzVyPUGuOFQ3PDdizszN NHuwZWZUSU6JRWK=
HUTU-80 M2mw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH4NlRKSzVyPUGuOFQ5QDZizszN M2KwdnNCVkeHUh?=
SIG-M5 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnvRllKSzVyPUGuOFg{QDdizszN M4DwdnNCVkeHUh?=
AGS NFvISplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3UTWM2OD1zLkWyNVI1KM7:TR?= NGDYSJRUSU6JRWK=
ST486 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPrTWM2OD1zLkWzNlc5KM7:TR?= MkDQV2FPT0WU
HSC-2 NHnDZY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTFwNUO5OUDPxE1? Mn7MV2FPT0WU
LCLC-103H MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XLb2lEPTB;MT61OVgyQCEQvF2= MWDTRW5ITVJ?
BC-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHH6dGVKSzVyPUGuOlE3PjRizszN NXi4eXhXW0GQR1XS
CGTH-W-1 MoPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWriZ4o4UUN3ME2xMlYyPjd7IN88US=> NHnNb4xUSU6JRWK=
MZ1-PC MlO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTFwNkKzNVIh|ryP M3jzVnNCVkeHUh?=
SW1710 NXnSOVZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe0TWM2OD1zLk[yOlI5KM7:TR?= M2\XS3NCVkeHUh?=
EW-13 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGniW|hKSzVyPUGuOlM1PjZizszN NWHsVFZIW0GQR1XS
TE-11 M3TwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfJSYhpUUN3ME2xMlY{PTJ{IN88US=> NI\2NXVUSU6JRWK=
BHY NGTx[lZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS5NHVKSzVyPUGuOlU3PjNizszN NIDvfpRUSU6JRWK=
ML-2 M2rOcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXUdWJDUUN3ME2xMlY3QDB{IN88US=> NF3WPWxUSU6JRWK=
MEL-JUSO M3eyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XPZ2lEPTB;MT63Nlg6OSEQvF2= Mmr3V2FPT0WU
U251 MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvlTWM2OD1zLke0NFMyKM7:TR?= Ml\rV2FPT0WU
MHH-ES-1 M13SbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDzTWM2OD1zLke5OVY5KM7:TR?= MnzRV2FPT0WU
CAL-85-1 NYfwfFdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LpdmlEPTB;MT64NFQ6KM7:TR?= NX7sZllMW0GQR1XS
D-336MG NVHhb2dvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DybWlEPTB;MT64OVYyPCEQvF2= NF65WHZUSU6JRWK=
VA-ES-BJ MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDJZVF1UUN3ME2xMlkxOzF3IN88US=> MlyyV2FPT0WU
MDA-MB-468 MnXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEmxb5NKSzVyPUGuPVEzPzJizszN NHf2R2RUSU6JRWK=
MEL-HO NIrvUGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWm3eFhJUUN3ME2xMlk4QTl|IN88US=> MWDTRW5ITVJ?
SW954 NG\ZSIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTJwMECxOVEh|ryP NYTRXXFSW0GQR1XS
LB831-BLC MmHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTSTWM2OD1{LkCwPVg5KM7:TR?= NXT1R|V[W0GQR1XS
EW-16 M3:zOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXTTWM2OD1{LkCzPVg{KM7:TR?= MmniV2FPT0WU
NCI-H460 NGe1cXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXBTWM2OD1{LkC0PFM6KM7:TR?= NGLyfGlUSU6JRWK=
CHP-212 MmHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3mTWM2OD1{LkC5OVM6KM7:TR?= M4nPOXNCVkeHUh?=
MHH-NB-11 NYfEZYZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\XTWM2OD1{LkGyPFE5KM7:TR?= NGXweoNUSU6JRWK=
DU-4475 Mmf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTrTI1KSzVyPUKuNVQ4PTlizszN M4Dv[HNCVkeHUh?=
ABC-1 M2XZOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nXS2lEPTB;Mj6yOVE6PiEQvF2= NVLabIFoW0GQR1XS
LOUCY NEC1Z4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJwMk[xNlgh|ryP NFTUcHNUSU6JRWK=
LC-2-ad NHPubmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnS[2lZUUN3ME2yMlI3QTZ4IN88US=> MVjTRW5ITVJ?
ETK-1 NXjIOplRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4POSmlEPTB;Mj6yPFQ3KM7:TR?= M4XzbHNCVkeHUh?=
KYSE-180 MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfnTWM2OD1{LkK4PFc1KM7:TR?= MnWzV2FPT0WU
HOP-92 NULHeFhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;jSXJKSzVyPUKuN|A3PzNizszN MY\TRW5ITVJ?
RCC10RGB NXL0NY1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2T3WGlEPTB;Mj6zNlUxPyEQvF2= MWXTRW5ITVJ?
KASUMI-1 NYqyTpg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvKTWM2OD1{LkOyPFgh|ryP NYG4XphlW0GQR1XS
ACN NVLjNXp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPmZY5KSzVyPUKuN|Q4PDVizszN MnfRV2FPT0WU
BxPC-3 NEfwTJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHlTpYyUUN3ME2yMlM2PDN4IN88US=> NV3Jem1IW0GQR1XS
MONO-MAC-6 NUXublR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37RNGlEPTB;Mj60NVI1QCEQvF2= MXXTRW5ITVJ?
CAL-39 NYLjc2t2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[0cIdKSzVyPUKuOFE3OjhizszN MlTVV2FPT0WU
CMK MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfqNHFpUUN3ME2yMlQyPzl3IN88US=> MVTTRW5ITVJ?
MFE-296 NH30XIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvaTWM2OD1{LkS3O|kzKM7:TR?= NGDIc5ZUSU6JRWK=
DU-145 MomzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzjWYtTUUN3ME2yMlQ6OTF6IN88US=> M3K1NXNCVkeHUh?=
MDA-MB-231 NIPk[2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2riRWlEPTB;Mj60PVU4OiEQvF2= M3;JVHNCVkeHUh?=
EFO-27 NWTycY1HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M124eGlEPTB;Mj61NVg5QCEQvF2= NIjHXZZUSU6JRWK=
SNU-387 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;xTWM2OD1{LkWyPFIh|ryP NXHpWpNFW0GQR1XS
KYSE-410 MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTXWIxKSzVyPUKuOVY2OTdizszN NGi2XoZUSU6JRWK=
NCCIT M4Hndmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTJwNUeyOEDPxE1? NWfxUGhUW0GQR1XS
LXF-289 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrpe29KSzVyPUKuOVgzPzNizszN MY\TRW5ITVJ?
HMV-II NIDoZpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW2VoVKSzVyPUKuOVg6QTdizszN MV3TRW5ITVJ?
MOLT-4 NELHcopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHVTWM2OD1{Lk[wO|EzKM7:TR?= MXzTRW5ITVJ?
KOSC-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlSxTWM2OD1{Lk[zPFc6KM7:TR?= MWDTRW5ITVJ?
TUR M{noN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF34dYtKSzVyPUKuOlU{PjlizszN NG[0dIFUSU6JRWK=
NCI-H2087 NUf0VINJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XIPWlEPTB;Mj63NVY1PiEQvF2= NVTCcotYW0GQR1XS
SCC-15 NEH5S5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTJwN{WyOVIh|ryP NXnRVYhRW0GQR1XS
HSC-4 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnxTWM2OD1{Lke4N|g6KM7:TR?= MmjPV2FPT0WU
G-402 MlzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTJwOEG0OFch|ryP M3XyUHNCVkeHUh?=
GP5d NWq0VmxWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJwOEO4Nlch|ryP NYTCT|hqW0GQR1XS
IGR-1 NXH5bnJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHj0S5dKSzVyPUKuPFM6QDdizszN MXLTRW5ITVJ?
SK-PN-DW NXjnbIZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1GzR2lEPTB;Mj64OlIxPCEQvF2= NXntPWN[W0GQR1XS
OPM-2 Ml76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJwOEm5O|gh|ryP MVLTRW5ITVJ?
5637 NIXqNnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJwOUK0N|kh|ryP NYjtZnppW0GQR1XS
NCI-H2030 MoLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDiTWM2OD1{Lkm4NFI6KM7:TR?= NX6zSpd5W0GQR1XS
SK-LU-1 NVPZV4pIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXmXZdVUUN3ME2yMlk5OzN2IN88US=> NXTYeWpkW0GQR1XS
EW-18 M2myNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnJTWM2OD1|LkC1N|Ih|ryP NXSwSXdMW0GQR1XS
786-0 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYH2NlV3UUN3ME2zMlA2Pzh2IN88US=> NIHzO4NUSU6JRWK=
NCI-H1963 NYLtfG85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCwOox7UUN3ME2zMlA5QDJ3IN88US=> MXvTRW5ITVJ?
A2780 NITrTZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGOzZ5BKSzVyPUOuNVA{PDFizszN MUTTRW5ITVJ?
NCI-H526 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4THNmlEPTB;Mz6xN|k3OSEQvF2= MnvRV2FPT0WU
BHT-101 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVX0fFZ{UUN3ME2zMlE2Pzl6IN88US=> M2fxTXNCVkeHUh?=
RPMI-7951 M4W4[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfBTWM2OD1|LkKwNVM4KM7:TR?= MYfTRW5ITVJ?
HL-60 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTNwMkGxOEDPxE1? M1vlUXNCVkeHUh?=
CTV-1 NWPF[|N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfZTWM2OD1|LkK1N|c4KM7:TR?= MmPnV2FPT0WU
IST-SL1 NXLr[VJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjaTWM2OD1|LkK5OFY2KM7:TR?= MonQV2FPT0WU
G-401 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTNUJZKSzVyPUOuNlk5ODhizszN M{npT3NCVkeHUh?=
OVCAR-5 NGPacWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7LdW81UUN3ME2zMlM3OzV{IN88US=> NXjiWY8zW0GQR1XS
EW-1 M1jm[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnBPIVxUUN3ME2zMlQxPTR2IN88US=> NFLPZmFUSU6JRWK=
H4 NVX0R3A3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVSzd5N6UUN3ME2zMlQ4PTZ7IN88US=> NFTpNWtUSU6JRWK=
EM-2 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTNwNEi2O|Qh|ryP M2WxN3NCVkeHUh?=
RS4-11 M4TXNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rOe2lEPTB;Mz60PFcyPSEQvF2= M1Xvb3NCVkeHUh?=
NOMO-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTGTWM2OD1|LkS5NlA1KM7:TR?= MmD6V2FPT0WU
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Capan-2 NFfPUYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILaWHVKSzVyPUO5MlA2ODlizszN NYTCZ5VQW0GQR1XS
SW756 MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS4TWM2OD1|OT61NFkyKM7:TR?= M1jIenNCVkeHUh?=
KU-19-19 Mm\xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTN7Lk[yPFIh|ryP MV;TRW5ITVJ?
NCI-H2170 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHqS3piUUN3ME2zPU46QTd5IN88US=> NEfqZnFUSU6JRWK=
COLO-678 NF65W2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjmTG9KSzVyPUSwMlU6PSEQvF2= M3vuTnNCVkeHUh?=
PF-382 M3HOeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XJVGlEPTB;NECuO|Q5PyEQvF2= NF\SVHNUSU6JRWK=
OAW-42 NF7yfGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPjTWM2OD12Mj6yPVQzKM7:TR?= NIftRXNUSU6JRWK=
LB996-RCC M2XWSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TQRWlEPTB;NEKuPFAxQCEQvF2= MofLV2FPT0WU
SAS NIrjXVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf2UVB{UUN3ME20N{41Ojh6IN88US=> NUjvNnRKW0GQR1XS
MRK-nu-1 NXXE[VA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTR2Lke0NVQh|ryP MmPyV2FPT0WU
EoL-1-cell MoPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPNdmZKSzVyPUS0MlkyOzZizszN M4jLOHNCVkeHUh?=
NCI-H2342 NUfLeXNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLXTWM2OD12NT6xNVE4KM7:TR?= MXLTRW5ITVJ?
NCI-H1703 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTR4LkC1PVIh|ryP MVnTRW5ITVJ?
NCI-H187 M1j0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnVTWM2OD12Nj6xPFY6KM7:TR?= NY\nPWdRW0GQR1XS
CP66-MEL M2nVR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYP0U4hsUUN3ME20Ok4zPzh7IN88US=> NHP1PG9USU6JRWK=
HCC1569 M16ycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjV[HlKSzVyPUS2MlU6OTdizszN Mn;WV2FPT0WU
BL-70 NIe2XXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zyd2lEPTB;NE[uO|c{PyEQvF2= MknYV2FPT0WU
Saos-2 M3LTV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHDSIRKSzVyPUS3MlMyOjNizszN NXnFb2hIW0GQR1XS
LC-1F MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPTepRKSzVyPUS3MlYyODVizszN Ml34V2FPT0WU
KY821 NGDTempIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfGTWM2OD12Nz62OFM1KM7:TR?= M2DnenNCVkeHUh?=
PSN1 NYq2OXBtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7ZbmlKSzVyPUS4MlE1ODFizszN NX;zeZZ4W0GQR1XS
RT4 Mo\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnaTWM2OD12OD64N|c4KM7:TR?= M3vDN3NCVkeHUh?=
LS-1034 M1LuWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nQV2lEPTB;NEiuPFk2PCEQvF2= MVLTRW5ITVJ?
NCI-H1395 NXT0fHFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTR7LkC0PVIh|ryP MWjTRW5ITVJ?
EKVX NX;DSFhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjiSJY2UUN3ME20PU43PzNzIN88US=> NVLCbGgzW0GQR1XS
IST-MES1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Hq[2lEPTB;NEmuPFk1PCEQvF2= M2rtcnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

体内研究 在携带U87MG的小鼠中PF-562271 (< 33 mg/kg 口服)抑制肿瘤中FAK磷酸化并具有时间和剂量依赖特性。PF-562271 (50 mg/kg, 口服,一天两次)对BxPc3异种移植小鼠中肿瘤生长抑制率为86% ,对PC3-M异种移植小鼠中肿瘤生长抑制率为45%。PF-562271 (25mg/kg, 一天两次)处理的携带H125肺部异种移植肿瘤凋亡率提高2倍[1]。 PF-562271 (33 mg/kg,口服)24小时后抑制小鼠中肿瘤细胞的广泛运动。PF-562271 (33 mg/kg, 口服)导致小鼠中E-cadherin动力学的改变,这与减弱的E-cadherin依赖的整体细胞运动有关 [3]。在皮下局部异种移植PC3M-luc-C6的小鼠模型中 PF-562271 (25 mg/kg, 口服,一天两次)导致肿瘤生长率62%的抑制[4]。在胫骨植入MDA-MB-231细胞的大鼠中PF-562271 (5mg/kg, 口服)导致骨钙素和松质骨参数显著而相似的增加同时导致肿瘤生长速度和骨愈合信号的下降[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:[1]
+ 展开
  • Animal Models: 携带BxPc3或 PC3-M异种移植的无胸腺雌性小鼠
  • Formulation: 5% Gelucire
  • Dosages: 50 mg/kg
  • Administration: 填喂给药
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL warmed (197.04 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 507.49
化学式

C21H20F3N7O3S

CAS号 717907-75-0
稳定性 powder
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

FAK Signaling Pathway Map

相关FAK产品

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID