PF-562271

目录号:S2890

PF-562271 Chemical Structure

Molecular Weight(MW): 507.49

PF-562271是一种有效的,ATP竞争性的,可逆的FAK抑制剂,无细胞试验中IC50为1.5 nM,作用于FAK比作用于Pyk2选择性高10倍左右,比作用于其他蛋白激酶(除了一些CDKs)选择性高100倍以上。

规格 价格 库存 购买数量  
RMB 2862.96 现货
RMB 1392.84 现货
RMB 2194.82 现货
RMB 5469.68 现货
RMB 7967.47 现货
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全国免费电话:400-668-6834   |   Email:info@selleck.cn

客户使用该产品的5个实验数据:

  • Effect of matrix stiffness on the susceptibility of primary HDFs to apoptosis induced by inhibition of mechanotransduction pathways. HDFs (primary human dermal fibroblasts) were cultured on collagen-coated polyacrylamide hydrogels that recapitulated the stiffness of normal (4 kPa) or densely fibrotic (50 kPa) skin for 24 hours and treated with or without the agents indicated for an additional 48 hours. Apoptosis was assessed by annexin V staining. Data are means ± SD from three independent experiments. P value was determined by Student’s t test.

    Science, 2017, 9(420), doi: 10.1126/scitranslmed.aal3765. PF-562271 purchased from Selleck.

    (F,G) The migration and invasion ability of 5637 and T24 cells transfected with PF-562271 and WT-METTL13 was examined. The number of cells was quantified and is shown in a column graph.

    Sci Rep, 2016, 6:19261. PF-562271 purchased from Selleck.

  • D-F. T47D cells plated as in A were treated with vehicle (−) or the FAK Y397 inhibitor, PF-562271 (+), for 1 h prior to ± PRL (4 nM) for 15 min (representative immunoblots).

    Oncotarget, 2016, 7(30):48093-48106. PF-562271 purchased from Selleck.

    OVISE cells were incubated for 24 hr at the indicated concentrations of the FAK inhibitors. Immunoblots were performed to assess inhibition of auto-phosphorylation by the FAK inhibitors.

    PLoS One 2014 9(2), e88587. PF-562271 purchased from Selleck.

  • VEGF and P450 enzyme production in response to FAK or Src inhibitors. MCF10A cells were cultured in LD collagen gels ?vehicle control (V), 10 uM PF-562271 FAK ATP inhibitor (PF) or Src inhibitor PP2 for 24 h. Cells were also lysed and examined for CYP1A1 or CYP4B1 by immunoblot (B and C) and densitometry (D and E). VEGF data are displayed as the mean normalized to the vehicle control, N = 6, 盨EM, *p < 0.003 vs control (A). P450 data are displayed as the mean relative to GAPDH and normalized to the control. N > 4, ±SEM, *p < 0.05 vs respective control (D and E).

    Environ Toxicol Pharmacol 2014 39(1), 114-124. PF-562271 purchased from Selleck.

产品安全说明书

FAK抑制剂选择性比较

生物活性

产品描述 PF-562271是一种有效的,ATP竞争性的,可逆的FAK抑制剂,无细胞试验中IC50为1.5 nM,作用于FAK比作用于Pyk2选择性高10倍左右,比作用于其他蛋白激酶(除了一些CDKs)选择性高100倍以上。
靶点
FAK [1]
(Cell-free assay)
PYK2 [1]
(Cell-free assay)
CDK2/CyclinE [1]
(Cell-free assay)
CDK3/CyclinE [1]
(Cell-free assay)
CDK1/CyclinB [1]
(Cell-free assay)
1.5 nM 13 nM 30 nM 47 nM 58 nM
体外研究

PF-562271会结合到ATP与FAK结合的部位,在激酶铰链区形成抑制剂与主链原子之间的两种氢键。PF-562271在测量FAK磷酸化可诱导的基于细胞的分析中效果很好,IC50为5 nM。PF-562271 (3.3 μM)导致PC3-M细胞周期停滞在G1期[1]。在鸡胚绒毛尿囊膜实验中PF-562271 (1nM)阻断bFGF刺激的血管生成。 PF-262271 强有效的阻断血管生长但对血管渗漏没有明显影响[2]。PF-562271 (250 nM)可以完全抑制整体A431 细胞侵入胶原蛋白中[3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MV-4-11 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fPTmlEPTB;MD6yO|Y3KM7:TR?= M3jQS3NCVkeHUh?=
SW982 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHziXm5KSzVyPUCuN|I5OiEQvF2= NX3FdIVIW0GQR1XS
KM12 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnQTWM2OD1yLkO4OVU4KM7:TR?= M{f0dnNCVkeHUh?=
COLO-205 M3e5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jPSWlEPTB;MD60PFY2QCEQvF2= M4\FPHNCVkeHUh?=
COLO-829 NFPqdGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TMeWlEPTB;MD63OVE4PiEQvF2= M3\6TXNCVkeHUh?=
MG-63 M1i0VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LmbGlEPTB;MD64NFY{PyEQvF2= NYXjSpRjW0GQR1XS
IGROV-1 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe2b5lKSzVyPUCuPFExOzhizszN NX;Rc5h[W0GQR1XS
NCI-H650 NUfSfZBpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;heWxDUUN3ME2wMlg{OTV2IN88US=> Mm\6V2FPT0WU
RT-112 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlP4TWM2OD1yLkm4OFYh|ryP NFLaN21USU6JRWK=
BCPAP M3\Bcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHKOHZLUUN3ME2xMlAyOjh6IN88US=> NULSWG1SW0GQR1XS
ALL-PO MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jJd2lEPTB;MT6wNVU5PCEQvF2= MUPTRW5ITVJ?
KYSE-270 NXnnZodqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Xpe2lEPTB;MT6wOFcyPCEQvF2= MnzKV2FPT0WU
8305C Mo\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;aXmxxUUN3ME2xMlA6QTB2IN88US=> NWH2SFlbW0GQR1XS
NCI-H810 NFfrO3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTFwMUC3O|Yh|ryP Mn\nV2FPT0WU
CAL-33 MkS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTGTWM2OD1zLkGyPVM5KM7:TR?= M{m0OHNCVkeHUh?=
AN3-CA NH\vfJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfUT5M{UUN3ME2xMlIyQDZ5IN88US=> M4\DOXNCVkeHUh?=
NKM-1 M{XxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1m2ZmlEPTB;MT6yO|UxPiEQvF2= NXzyVXZLW0GQR1XS
BPH-1 Mn[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPZTWM2OD1zLkK4O|Y3KM7:TR?= NWXyOIFFW0GQR1XS
MES-SA MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTFwM{C2PFIh|ryP NFW5R4pUSU6JRWK=
CAL-62 NI\HSVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHpd4VDUUN3ME2xMlMyQTB7IN88US=> NFLDeGZUSU6JRWK=
Detroit562 MmTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{CyWGlEPTB;MT6zOVIzOiEQvF2= MoH4V2FPT0WU
KYSE-150 NFfXbZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF6zZZlKSzVyPUGuN|UzOzZizszN NELyfndUSU6JRWK=
SK-UT-1 M3zHUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\KPGlEPTB;MT60OFY1PyEQvF2= MmG2V2FPT0WU
HUTU-80 MnPUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\4TWlEPTB;MT60OFg5PiEQvF2= NHnYOWRUSU6JRWK=
SIG-M5 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3LTWM2OD1zLkS4N|g4KM7:TR?= M1v4OHNCVkeHUh?=
AGS M4nqVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTFwNUKxNlQh|ryP NXjrc2FxW0GQR1XS
ST486 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTFwNUOyO|gh|ryP MUfTRW5ITVJ?
HSC-2 NHzUU5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDITWM2OD1zLkWzPVUh|ryP MnfGV2FPT0WU
LCLC-103H MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTFwNUW4NVgh|ryP NHLyZlJUSU6JRWK=
BC-1 M{HLXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDMTIRKSzVyPUGuOlE3PjRizszN M1fuUXNCVkeHUh?=
CGTH-W-1 MofyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWntfnBoUUN3ME2xMlYyPjd7IN88US=> MortV2FPT0WU
MZ1-PC MmL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fLdWlEPTB;MT62NlMyOiEQvF2= NVfreI1RW0GQR1XS
SW1710 NWrkNGdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTFwNkK2Nlgh|ryP MVTTRW5ITVJ?
EW-13 NWTkOmxuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P2[2lEPTB;MT62N|Q3PiEQvF2= NGrDVWxUSU6JRWK=
TE-11 Mof6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXGTWM2OD1zLk[zOVIzKM7:TR?= M4DGXnNCVkeHUh?=
BHY MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrnTWM2OD1zLk[1OlY{KM7:TR?= NV;tZXJCW0GQR1XS
ML-2 M330Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4D0OWlEPTB;MT62OlgxOiEQvF2= NHiw[YtUSU6JRWK=
MEL-JUSO Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTFwN{K4PVEh|ryP Mmn2V2FPT0WU
U251 NEi1NIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVztRo5OUUN3ME2xMlc1ODNzIN88US=> MkLxV2FPT0WU
MHH-ES-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTFwN{m1Olgh|ryP NHTVWFBUSU6JRWK=
CAL-85-1 MlLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\RNZVKSzVyPUGuPFA1QSEQvF2= M1LoR3NCVkeHUh?=
D-336MG NWO5eooxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPVTWM2OD1zLki1OlE1KM7:TR?= NVKzUI9JW0GQR1XS
VA-ES-BJ MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XLVGlEPTB;MT65NFMyPSEQvF2= NInG[5ZUSU6JRWK=
MDA-MB-468 M4TjR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDkbW1JUUN3ME2xMlkyOjd{IN88US=> NEHvWZNUSU6JRWK=
MEL-HO MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrJdIFKSzVyPUGuPVc6QTNizszN MXfTRW5ITVJ?
SW954 Ml25S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\mSZNKSzVyPUKuNFAyPTFizszN NIrZOFZUSU6JRWK=
LB831-BLC NV\O[3RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVS3PGdWUUN3ME2yMlAxQTh6IN88US=> Mn3TV2FPT0WU
EW-16 M1;iWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHvTWM2OD1{LkCzPVg{KM7:TR?= NUD0[3pvW0GQR1XS
NCI-H460 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7pTWM2OD1{LkC0PFM6KM7:TR?= NXjldGpRW0GQR1XS
CHP-212 M4jpVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1WzW2lEPTB;Mj6wPVU{QSEQvF2= NFXZc|VUSU6JRWK=
MHH-NB-11 MmnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3MTWM2OD1{LkGyPFE5KM7:TR?= MoTMV2FPT0WU
DU-4475 NHTEbmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPy[o5[UUN3ME2yMlE1PzV7IN88US=> M4nQR3NCVkeHUh?=
ABC-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4npfGlEPTB;Mj6yOVE6PiEQvF2= NFjudYVUSU6JRWK=
LOUCY NXL1O2JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIP3c5dKSzVyPUKuNlYyOjhizszN MV\TRW5ITVJ?
LC-2-ad NVfrXm53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\LWGlEPTB;Mj6yOlk3PiEQvF2= MmTKV2FPT0WU
ETK-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnJN5JKSzVyPUKuNlg1PiEQvF2= MUjTRW5ITVJ?
KYSE-180 M{jRd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{j5RWlEPTB;Mj6yPFg4PCEQvF2= MVzTRW5ITVJ?
HOP-92 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkG4TWM2OD1{LkOwOlc{KM7:TR?= NF;yZZhUSU6JRWK=
RCC10RGB NYjRUnpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJwM{K1NFch|ryP NFfS[HFUSU6JRWK=
KASUMI-1 Mo\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4G0fmlEPTB;Mj6zNlg5KM7:TR?= M4nCTnNCVkeHUh?=
ACN MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTJwM{S3OFUh|ryP M1\XeHNCVkeHUh?=
BxPC-3 NFrINIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2exR2lEPTB;Mj6zOVQ{PiEQvF2= NHXDfnVUSU6JRWK=
MONO-MAC-6 M2eyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPKTWM2OD1{LkSxNlQ5KM7:TR?= MXnTRW5ITVJ?
CAL-39 M1jjZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfhSplHUUN3ME2yMlQyPjJ6IN88US=> M3zyVnNCVkeHUh?=
CMK MmXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH[2XFRKSzVyPUKuOFE4QTVizszN NUP5dXVrW0GQR1XS
MFE-296 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDzeYNGUUN3ME2yMlQ4Pzl{IN88US=> M3vnbXNCVkeHUh?=
DU-145 MoDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorGTWM2OD1{LkS5NVE5KM7:TR?= NXP2WHdbW0GQR1XS
MDA-MB-231 NV7mb5Z2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TIW2lEPTB;Mj60PVU4OiEQvF2= Mn7oV2FPT0WU
EFO-27 M2jkW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13DN2lEPTB;Mj61NVg5QCEQvF2= MVLTRW5ITVJ?
SNU-387 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTJwNUK4NkDPxE1? MXvTRW5ITVJ?
KYSE-410 M3S3SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Ozc2lEPTB;Mj61OlUyPyEQvF2= MYHTRW5ITVJ?
NCCIT M{H0PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L0[mlEPTB;Mj61O|I1KM7:TR?= MVHTRW5ITVJ?
LXF-289 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTJwNUiyO|Mh|ryP NV\1ZnJtW0GQR1XS
HMV-II NFe1S21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DlcWlEPTB;Mj61PFk6PyEQvF2= MYXTRW5ITVJ?
MOLT-4 NEPEbIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfIU3VxUUN3ME2yMlYxPzF{IN88US=> Mk\FV2FPT0WU
KOSC-2 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFL1cWxKSzVyPUKuOlM5PzlizszN NGG4doVUSU6JRWK=
TUR MnnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{G0UmlEPTB;Mj62OVM3QSEQvF2= NFjlcndUSU6JRWK=
NCI-H2087 MoLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7hRmNKSzVyPUKuO|E3PDZizszN NX61SoRWW0GQR1XS
SCC-15 MnzHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELmWIZKSzVyPUKuO|UzPTJizszN Ml:xV2FPT0WU
HSC-4 NF7qb2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX[0eXJ1UUN3ME2yMlc5Ozh7IN88US=> MVnTRW5ITVJ?
G-402 NFrV[IJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTJwOEG0OFch|ryP NEjLOVRUSU6JRWK=
GP5d NXOyfGZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fPc2lEPTB;Mj64N|gzPyEQvF2= MoKzV2FPT0WU
IGR-1 NYfWOHNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\qU4RrUUN3ME2yMlg{QTh5IN88US=> NFfzRZRUSU6JRWK=
SK-PN-DW MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTJwOE[yNFQh|ryP MUnTRW5ITVJ?
OPM-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFewZoFKSzVyPUKuPFk6PzhizszN NEPLV|BUSU6JRWK=
5637 NWD2WnhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;QUGlEPTB;Mj65NlQ{QSEQvF2= NGSySnJUSU6JRWK=
NCI-H2030 NYfDO3NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTJwOUiwNlkh|ryP MWDTRW5ITVJ?
SK-LU-1 MnjkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmroTWM2OD1{Lkm4N|M1KM7:TR?= M{n4[HNCVkeHUh?=
EW-18 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTNwMEWzNkDPxE1? MoexV2FPT0WU
786-0 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHsRnVKSzVyPUOuNFU4QDRizszN NHXPWHdUSU6JRWK=
NCI-H1963 NYrnfWtJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2ThRWlEPTB;Mz6wPFgzPSEQvF2= M13xNXNCVkeHUh?=
A2780 MonnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DqdWlEPTB;Mz6xNFM1OSEQvF2= NEHISY5USU6JRWK=
NCI-H526 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrFPIl{UUN3ME2zMlE{QTZzIN88US=> NIT0cVhUSU6JRWK=
BHT-101 MmPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrUTWM2OD1|LkG1O|k5KM7:TR?= NXvsU284W0GQR1XS
RPMI-7951 NGfiS2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnrTWM2OD1|LkKwNVM4KM7:TR?= M1HZNnNCVkeHUh?=
HL-60 M13sdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLVTWM2OD1|LkKxNVQh|ryP NEDQUHRUSU6JRWK=
CTV-1 MmLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTNwMkWzO|ch|ryP M17u[3NCVkeHUh?=
IST-SL1 MkLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTNwMkm0OlUh|ryP M2L2S3NCVkeHUh?=
G-401 NUD3c|BzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXDTWM2OD1|LkK5PFA5KM7:TR?= NYSyeG83W0GQR1XS
OVCAR-5 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLiTWM2OD1|LkO2N|UzKM7:TR?= NUHC[HJkW0GQR1XS
EW-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIf3XZVKSzVyPUOuOFA2PDRizszN MWPTRW5ITVJ?
H4 MnPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\Ib|JKSzVyPUOuOFc2PjlizszN M17SZ3NCVkeHUh?=
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NCI-H2052 NHLiRWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTFyLkWxNFUh|ryP M{PQZXNCVkeHUh?=
NCI-H2452 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTFyLk[xPFEh|ryP NX;z[Y9XW0GQR1XS
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COLO-320-HSR MljIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXH5XJg2UUN3ME2xNU45PTF7IN88US=> MVTTRW5ITVJ?
L-540 MlXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUHuXZFiUUN3ME2xNU45QTlizszN NVSzTlFzW0GQR1XS
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CAL-27 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUX3dXl7UUN3ME2xNk4yOzZ7IN88US=> NFrsZlJUSU6JRWK=
NCI-H1437 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTF{LkG0OFch|ryP MnfVV2FPT0WU
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NCI-H1792 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TpeGlEPTB;MUKuN|g2OSEQvF2= M36xN3NCVkeHUh?=
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HAL-01 NWDjPWxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrPRmtKSzVyPUGyMlYyPzRizszN MnLqV2FPT0WU
NCI-H2141 MmDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIr4UFdKSzVyPUGyMlY2QCEQvF2= MWrTRW5ITVJ?
HCC1806 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;3TWM2OD1zMj62PVUzKM7:TR?= M1r4U3NCVkeHUh?=
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HT M{nZOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILwUY5KSzVyPUGyMlk1OzdizszN NGnxOoxUSU6JRWK=
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LB2241-RCC Mn3yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XOXWlEPTB;MUOuNVQ3QSEQvF2= MojGV2FPT0WU
CCF-STTG1 NIe3WWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTTd4xKUUN3ME2xN{41ODN7IN88US=> MnXEV2FPT0WU
RPMI-8402 M4\HNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnvTWM2OD1zMz61NFMyKM7:TR?= NWm4do1KW0GQR1XS
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NUGC-3 MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX32fW9oUUN3ME2xN{44PDV|IN88US=> M4eySnNCVkeHUh?=
CAL-72 NH\INJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfmTWM2OD1zND6xPVA3KM7:TR?= MWDTRW5ITVJ?
VMRC-RCZ NUf1eo9tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTF2LkKzOkDPxE1? NUP4RoRzW0GQR1XS
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CAL-12T NIHiboVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHFTWM2OD1zND60N|M3KM7:TR?= NVLVWFFiW0GQR1XS
GAMG NGnZfGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2CwOmlEPTB;MUSuOVU4PyEQvF2= MYTTRW5ITVJ?
BT-20 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIK5cpFKSzVyPUG0Mlk{QDRizszN MWPTRW5ITVJ?
KALS-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDoWpc1UUN3ME2xOU4xOTV6IN88US=> M{PDb3NCVkeHUh?=
LS-123 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTF3LkCxOlUh|ryP NF6wUVVUSU6JRWK=
LK-2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PB[mlEPTB;MUWuNFg3OiEQvF2= NVf6SZJWW0GQR1XS
NCI-H1770 NEXqZYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHKbIR6UUN3ME2xOU4zQDZ6IN88US=> NGG1ZYFUSU6JRWK=
MIA-PaCa-2 NVLsVWI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF3LkSxOlMh|ryP MmrNV2FPT0WU
DB Mn\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{m5eWlEPTB;MUWuOlk1OSEQvF2= MUHTRW5ITVJ?
Becker MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTF3Lki5NlYh|ryP MV;TRW5ITVJ?
HT-144 M3;vWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljLTWM2OD1zNT65OFk4KM7:TR?= MWDTRW5ITVJ?
NCI-H2405 NF7VbolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFS1SVBKSzVyPUG2MlIzOThizszN MWjTRW5ITVJ?
TK10 NHXFXppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq4PIJKSzVyPUG2MlM4PDJizszN NGK3VmhUSU6JRWK=
THP-1 M4PsWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTF4LkS2OlUh|ryP NHGwfHZUSU6JRWK=
LB373-MEL-D NHXye5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXnbpdKSzVyPUG2MlYyOzhizszN NFPMT2lUSU6JRWK=
SJSA-1 NFjGVVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTF4LkmyNVkh|ryP M2rRNnNCVkeHUh?=
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MN-60 NV70Ro1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnyTWM2OD1zNz63PVM3KM7:TR?= MnriV2FPT0WU
A253 NU\ETnNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTF5LkiyOUDPxE1? M{PvUXNCVkeHUh?=
CESS MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTF5LkmzNlYh|ryP Mm\EV2FPT0WU
EW-11 MnLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTF5Lkm5OVgh|ryP NWT1fW46W0GQR1XS
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MDA-MB-453 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnj[XFmUUN3ME2zPU4xOjF6IN88US=> NUDhNY1KW0GQR1XS
Capan-2 Mo\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTN7LkC1NFkh|ryP MlPiV2FPT0WU
SW756 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\aR4JKSzVyPUO5MlUxQTFizszN Mnm1V2FPT0WU
KU-19-19 NVHzRnRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLHTWM2OD1|OT62NlgzKM7:TR?= NF[1UYRUSU6JRWK=
NCI-H2170 Ml3oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLlUJE5UUN3ME2zPU46QTd5IN88US=> Ml\iV2FPT0WU
COLO-678 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fZe2lEPTB;NECuOVk2KM7:TR?= NEjHXnpUSU6JRWK=
PF-382 NVPjbI1ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvuVlVKSzVyPUSwMlc1QDdizszN MVXTRW5ITVJ?
OAW-42 NH\CUlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli4TWM2OD12Mj6yPVQzKM7:TR?= MkHRV2FPT0WU
LB996-RCC Ml72S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7hTWM2OD12Mj64NFA5KM7:TR?= NX;5VGJYW0GQR1XS
SAS M4LDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnq1TWM2OD12Mz60Nlg5KM7:TR?= NH7aPIhUSU6JRWK=
MRK-nu-1 NFXTbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTR2Lke0NVQh|ryP NXrmcIlqW0GQR1XS
EoL-1-cell MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXtbJBsUUN3ME20OE46OTN4IN88US=> M1v6SXNCVkeHUh?=
NCI-H2342 M2W4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmjaTWM2OD12NT6xNVE4KM7:TR?= NGPMN2ZUSU6JRWK=
NCI-H1703 M33y[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHueJhPUUN3ME20Ok4xPTl{IN88US=> M2i4eHNCVkeHUh?=
NCI-H187 NX7Zc|B5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HqcmlEPTB;NE[uNVg3QSEQvF2= MU\TRW5ITVJ?
CP66-MEL NUOxSpQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGflb|RKSzVyPUS2MlI4QDlizszN MX;TRW5ITVJ?
HCC1569 M{DjVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HINGlEPTB;NE[uOVkyPyEQvF2= M2K4PHNCVkeHUh?=
BL-70 NXjnPG1IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTR4Lke3N|ch|ryP NVr2WohJW0GQR1XS
Saos-2 NEDad2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHjd4ZKSzVyPUS3MlMyOjNizszN NF:zXW9USU6JRWK=
LC-1F NFm3UmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\kZpBiUUN3ME20O{43OTB3IN88US=> NWfjfGY2W0GQR1XS
KY821 MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLMTWM2OD12Nz62OFM1KM7:TR?= NYf5dlc3W0GQR1XS
PSN1 M1nsNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTR6LkG0NFEh|ryP Mn\oV2FPT0WU
RT4 M3SxWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjPWmF7UUN3ME20PE45Ozd5IN88US=> MmLNV2FPT0WU
LS-1034 NUXTd2hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnQRWZKSzVyPUS4Mlg6PTRizszN Mo\uV2FPT0WU
NCI-H1395 MlrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEKwS2VKSzVyPUS5MlA1QTJizszN M3vnWnNCVkeHUh?=
EKVX M1nyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTR7Lk[3N|Eh|ryP M2Pl[3NCVkeHUh?=
IST-MES1 NVKyNWpwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHXc3VDUUN3ME20PU45QTR2IN88US=> M2TjSXNCVkeHUh?=

... Click to View More Cell Line Experimental Data

体内研究 在携带U87MG的小鼠中PF-562271 (< 33 mg/kg 口服)抑制肿瘤中FAK磷酸化并具有时间和剂量依赖特性。PF-562271 (50 mg/kg, 口服,一天两次)对BxPc3异种移植小鼠中肿瘤生长抑制率为86% ,对PC3-M异种移植小鼠中肿瘤生长抑制率为45%。PF-562271 (25mg/kg, 一天两次)处理的携带H125肺部异种移植肿瘤凋亡率提高2倍[1]。 PF-562271 (33 mg/kg,口服)24小时后抑制小鼠中肿瘤细胞的广泛运动。PF-562271 (33 mg/kg, 口服)导致小鼠中E-cadherin动力学的改变,这与减弱的E-cadherin依赖的整体细胞运动有关 [3]。在皮下局部异种移植PC3M-luc-C6的小鼠模型中 PF-562271 (25 mg/kg, 口服,一天两次)导致肿瘤生长率62%的抑制[4]。在胫骨植入MDA-MB-231细胞的大鼠中PF-562271 (5mg/kg, 口服)导致骨钙素和松质骨参数显著而相似的增加同时导致肿瘤生长速度和骨愈合信号的下降[5]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

动物实验:[1]
+ 展开
  • Animal Models: 携带BxPc3或 PC3-M异种移植的无胸腺雌性小鼠
  • Formulation: 5% Gelucire
  • Dosages: 50 mg/kg
  • Administration: 填喂给药
    (Only for Reference)

溶解度 (25°C)

体外 DMSO 100 mg/mL warmed (197.04 mM)
Water Insoluble
Ethanol Insoluble
体内 从左到右依次将纯溶剂加入产品,现配现用:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 507.49
化学式

C21H20F3N7O3S

CAS号 717907-75-0
稳定性 powder
in solvent
别名 N/A

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (g) = 浓度 (mol/L) x 体积 (L) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

  • * 必填项

FAK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID