Acetyl-CoA carboxylase

亚型特异性产品

ACC ACC1 ACC2

Acetyl-CoA carboxylase产品

所有产品(9)
Acetyl-CoA carboxylase抑制剂 (7)
Acetyl-CoA carboxylase抗体 (1)
新Acetyl-CoA carboxylase产品

目录号	产品名	产品描述	文献引用	实验数据
S8893	Firsocostat (GS-0976, ND-630)	Firsocostat (GS-0976, ND-630)是acetyl CoA carboxylase (ACC)的一种可逆抑制剂，对hACC1和hACC2的IC50分别为2.1 nM，6.1 nM。	Adv Sci (Weinh), 2024, 11(46):e2401311 Nat Commun, 2023, 14(1):1362 Genome Med, 2022, 14(1):67
S6753	CP 640186	CP 640186是ACC (Acetyl-CoA carboxylase)抑制剂，对大鼠肝脏ACC1和骨骼肌ACC2的IC50分别为53 nM和61 nM。	Exp Ther Med, 2020, 20(1):521-529 Molecules, 2015, 20(9):16221-34 Molecules, 2015, 20(9):16221-34
S8377	ND646	ND-646 是一种 ACC (Acetyl-coA carboxylase) enzymes 的变构抑制剂，可防止ACC亚基二聚化，从而抑制脂肪酸合成，对hACC1和hACC2的IC50值分别为3.5 nM和4.1 nM。	Cancer Discov, 2023, 13(2):496-515 Cancer Sci, 2023, 114(4):1651-1662 Cancer Sci, 2023, 114(4):1651-1662
S6690	TOFA	TOFA 是acetyl-CoA carboxylase-α (ACCA)的变构抑制剂。在细胞内TOFA转化为TOFyl-CoA (5-tetradecyloxy-2-furoyl-CoA)，对ACCA具有变构抑制作用。 TOFA阻止脂肪酸合成，并以剂量依赖性方式诱导细胞死亡。	Cell Death Dis, 2024, 15(10):755 bioRxiv, 2024, 2024.02.22.581432 Cancer Commun (Lond), 2022, 10.1002/cac2.12380
S6672	PF-05175157	PF-05175157是一种广谱有效的ACC抑制剂，对人ACC1，人ACC2，大鼠ACC1和大鼠ACC2的IC50分别为27.0 nM、33.0 nM、23.5 nM和50.4 nM。	Nat Commun, 2025, 16(1):509 Cancer Cell Int, 2023, 23(1):83 Liver Res-Prc, 2023, Volume 7, Issue 2 Pages 124-135
F0270^New	Acetyl-CoA Carboxylase Rabbit mAb	Acetyl-CoA Carboxylase Rabbit mAb recognizes endogenous levels of total Acetyl-CoA Carboxylase protein.
S5519	4-Methylsalicylic acid	4-Methylsalicylic acid (m-Cresotic acid, 2-Hydroxy-4-methylbenzoic acid, m-Cresotinic acid, 2-Hydroxy-p-toluic acid) is used to inhibit the medium chain acyl-CoA synthetase.
S6145	PF-05221304	PF-05221304 是一种口服可生物利用的，肝靶向的 acetyl-CoA carboxylase (ACC) 的抑制剂，是一种催化脂肪从头生成(DNL)的第一步的酶。
S6112	Oxalacetic acid	Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid)是三羧酸循环的中间物，它与乙酰辅酶A经柠檬酸合酶催化反应生成柠檬酸盐。它还参与糖原异生、尿素循环、乙醛酸循环、氨基酸合成和脂肪酸合成等过程。Oxaloacetate是Complex II的抑制剂。
S8893	Firsocostat (GS-0976, ND-630)	Firsocostat (GS-0976, ND-630)是acetyl CoA carboxylase (ACC)的一种可逆抑制剂，对hACC1和hACC2的IC50分别为2.1 nM，6.1 nM。	Adv Sci (Weinh), 2024, 11(46):e2401311 Nat Commun, 2023, 14(1):1362 Genome Med, 2022, 14(1):67
S6753	CP 640186	CP 640186是ACC (Acetyl-CoA carboxylase)抑制剂，对大鼠肝脏ACC1和骨骼肌ACC2的IC50分别为53 nM和61 nM。	Exp Ther Med, 2020, 20(1):521-529 Molecules, 2015, 20(9):16221-34 Molecules, 2015, 20(9):16221-34
S8377	ND646	ND-646 是一种 ACC (Acetyl-coA carboxylase) enzymes 的变构抑制剂，可防止ACC亚基二聚化，从而抑制脂肪酸合成，对hACC1和hACC2的IC50值分别为3.5 nM和4.1 nM。	Cancer Discov, 2023, 13(2):496-515 Cancer Sci, 2023, 114(4):1651-1662 Cancer Sci, 2023, 114(4):1651-1662
S6690	TOFA	TOFA 是acetyl-CoA carboxylase-α (ACCA)的变构抑制剂。在细胞内TOFA转化为TOFyl-CoA (5-tetradecyloxy-2-furoyl-CoA)，对ACCA具有变构抑制作用。 TOFA阻止脂肪酸合成，并以剂量依赖性方式诱导细胞死亡。	Cell Death Dis, 2024, 15(10):755 bioRxiv, 2024, 2024.02.22.581432 Cancer Commun (Lond), 2022, 10.1002/cac2.12380
S6672	PF-05175157	PF-05175157是一种广谱有效的ACC抑制剂，对人ACC1，人ACC2，大鼠ACC1和大鼠ACC2的IC50分别为27.0 nM、33.0 nM、23.5 nM和50.4 nM。	Nat Commun, 2025, 16(1):509 Cancer Cell Int, 2023, 23(1):83 Liver Res-Prc, 2023, Volume 7, Issue 2 Pages 124-135
S5519	4-Methylsalicylic acid	4-Methylsalicylic acid (m-Cresotic acid, 2-Hydroxy-4-methylbenzoic acid, m-Cresotinic acid, 2-Hydroxy-p-toluic acid) is used to inhibit the medium chain acyl-CoA synthetase.
S6145	PF-05221304	PF-05221304 是一种口服可生物利用的，肝靶向的 acetyl-CoA carboxylase (ACC) 的抑制剂，是一种催化脂肪从头生成(DNL)的第一步的酶。
F0270^New	Acetyl-CoA Carboxylase Rabbit mAb	Acetyl-CoA Carboxylase Rabbit mAb recognizes endogenous levels of total Acetyl-CoA Carboxylase protein.
F0270^New	Acetyl-CoA Carboxylase Rabbit mAb	Acetyl-CoA Carboxylase Rabbit mAb recognizes endogenous levels of total Acetyl-CoA Carboxylase protein.

Acetyl-CoA carboxylase抑制剂选择性比较

Tags: Acetyl-CoA carboxylase inhibitor|Acetyl-CoA carboxylase agonist|Acetyl-CoA carboxylase activator|Acetyl-CoA carboxylase inducer|Acetyl-CoA carboxylase antagonist|Acetyl-CoA carboxylase signaling pathway|Acetyl-CoA carboxylase assay kit