CaSR
信号通路图
研究领域
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S1260 | Cinacalcet HCl | <1 mg/mL | 79 mg/mL | 33 mg/mL |
| S2633 | NPS-2143 | <1 mg/mL | 82 mg/mL | <1 mg/mL |
- CaSR抑制剂（2）
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1260 |
Cinacalcet HClCinacalcet HCl是一种用于治疗甲状旁腺功能亢进的新型化合物。 |
A. SK-N-LP cells stably transfected with pCMV-GFP or pCMV-CaSR-GFP were grown in serum deprivation media for 16 hours. They were then exposed to cinacalcet for 24 hours at indicated doses in the same media containing 0.5 mM CaCl2 . Total proteins were isolated from floating and adherent cells to conduct immunoblots.
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| S2633 |
NPS-2143NPS-2143是一种新型有效的，选择性的Ca(2+)受体拮抗剂，IC50为43 nM。 |
The effects of a GPRC6A inhibitor on testosterone-induced ROS generation. Cells were pretreated with the GPRC6A inhibitor, NPS2143 (1 uM), for 30 min and ROS generation was monitored after 5 min of testosterone treatment. Data are presented as mean ?S.E. (n = 4).
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