CaSR
信号通路图
研究领域
抑制剂选择性比较
CaSR产品
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1260 |
Cinacalcet HClCinacalcet HCl是一种用于治疗甲状旁腺功能亢进的新型化合物。 |
Effects of intra-synovial injections of CaSR antagonist (NPS2143) and agonist (Cinacalcet) on morphology (A) in rat TMJ cartilage without (Control) or with UAC stimulation. Test compounds (50 μL of 100 nM stock) and vehicle injections were performed on 10‐week‐old rats every other day for 4 weeks. UAC began 4 weeks before drug injections and continued for another 4 weeks during drug treatments. (A) Safranin O staining (in red) showed the ability of NPS2143 to increase proteoglycan content and thickness of TMJ cartilage and decreased OA grade, the ability of Cinacalcet to suppress these parameters in both control and UAC groups when compared with corresponding vehicle‐injected group. Scale bar = 100 µm. n = 6 rats per group.
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| S2633 |
NPS-2143NPS-2143是一种新型有效的，选择性的Ca(2+)受体拮抗剂，IC50为43 nM。 |
The effects of a GPRC6A inhibitor on testosterone-induced ROS generation. Cells were pretreated with the GPRC6A inhibitor, NPS2143 (1 uM), for 30 min and ROS generation was monitored after 5 min of testosterone treatment. Data are presented as mean ?S.E. (n = 4).
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| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S1260 |
Cinacalcet HClCinacalcet HCl是一种用于治疗甲状旁腺功能亢进的新型化合物。 |
Effects of intra-synovial injections of CaSR antagonist (NPS2143) and agonist (Cinacalcet) on morphology (A) in rat TMJ cartilage without (Control) or with UAC stimulation. Test compounds (50 μL of 100 nM stock) and vehicle injections were performed on 10‐week‐old rats every other day for 4 weeks. UAC began 4 weeks before drug injections and continued for another 4 weeks during drug treatments. (A) Safranin O staining (in red) showed the ability of NPS2143 to increase proteoglycan content and thickness of TMJ cartilage and decreased OA grade, the ability of Cinacalcet to suppress these parameters in both control and UAC groups when compared with corresponding vehicle‐injected group. Scale bar = 100 µm. n = 6 rats per group.
|
| 目录号 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S2633 |
NPS-2143NPS-2143是一种新型有效的，选择性的Ca(2+)受体拮抗剂，IC50为43 nM。 |
The effects of a GPRC6A inhibitor on testosterone-induced ROS generation. Cells were pretreated with the GPRC6A inhibitor, NPS2143 (1 uM), for 30 min and ROS generation was monitored after 5 min of testosterone treatment. Data are presented as mean ?S.E. (n = 4).
|
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