Decarboxylase

Decarboxylase产品

目录号	产品描述	文献引用	实验数据
S1891	Carbidopa Carbidopa 是一种芳香族-L-氨基酸脱羧酶抑制剂，IC50为29±2 μM。	Signal Transduct Target Ther, 2021, 6(1):77 PLoS One, 2017, 12(3):e0173240
S2453	Benserazide HCl Benserazide HCl (Ro-4-4602)是一种外周性的芳香族L-氨基酸脱羧酶（AAAD）或DOPA脱羧酶抑制剂。
S3086New	Maleic acid Maleic acid 可抑制 glutamate decarboxylase (GAD) 的活性，从而增强 Listeria monocytogenes 的酸敏感性。Maleic acid 会影响细胞外 GABA 的水平。
S1642	Methyldopa Methyldopa 是DOPA 脱羧酶竞争性抑制剂，ED50为21.8 mg/kg。
S0108	AZ-33 AZ-33 (LDHA Inhibitor 33)是一种 lactate dehydrogenase A (LDHA) 的有效抑制剂，其IC50值为0.5 μM。LDHA是参与厌氧糖酵解的关键酶，在人类恶性肿瘤中该酶经常失活。
S4582	Eflornithine (MDL-71782) hydrochloride hydrate Eflornithine (Difluoromethylornithine, DFMO, MDL-71782, RMI-71782, α-difluoromethylornithine) hydrochloride hydrate 通过对鸟氨酸脱羧酶的不可逆抑制作用，抑制多胺生物合成。它是一种化疗保护剂，可阻止血管生成。其生物半衰期为8小时。	Cell, 2021, S0092-8674(21)00700-5 Front Cell Infect Microbiol, 2020, 16;10:158
S5448	S(-)-Carbidopa S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
S5444	4-Bromo-3-hydroxybenzoic acid 4-bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals.
S5579	Chelidonic acid Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) 是在几种植物中发现的次级代谢产物，对实验动物的过敏性疾病具有治疗潜力。Chelidonic acid 通过阻断HMC-1细胞中的 NF-κB 和 caspase-1 来抑制 IL-6 的产生。Chelidonic acid 也是 glutamate decarboxylase 的抑制剂，其Ki值为1.2 μM。
S5409	Chelidamic acid hydrate Chelidamic acid is a pharmaceutical intermediate as well as a cosmetic material due to its anti-inflammatory and whitening effect. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.

目录号	产品描述	文献引用	实验数据
S1891	Carbidopa Carbidopa 是一种芳香族-L-氨基酸脱羧酶抑制剂，IC50为29±2 μM。	Signal Transduct Target Ther,2021, 6(1):77 PLoS One,2017, 12(3):e0173240
S2453	Benserazide HCl Benserazide HCl (Ro-4-4602)是一种外周性的芳香族L-氨基酸脱羧酶（AAAD）或DOPA脱羧酶抑制剂。
S3086New	Maleic acid Maleic acid 可抑制 glutamate decarboxylase (GAD) 的活性，从而增强 Listeria monocytogenes 的酸敏感性。Maleic acid 会影响细胞外 GABA 的水平。
S1642	Methyldopa Methyldopa 是DOPA 脱羧酶竞争性抑制剂，ED50为21.8 mg/kg。
S0108	AZ-33 AZ-33 (LDHA Inhibitor 33)是一种 lactate dehydrogenase A (LDHA) 的有效抑制剂，其IC50值为0.5 μM。LDHA是参与厌氧糖酵解的关键酶，在人类恶性肿瘤中该酶经常失活。
S4582	Eflornithine (MDL-71782) hydrochloride hydrate Eflornithine (Difluoromethylornithine, DFMO, MDL-71782, RMI-71782, α-difluoromethylornithine) hydrochloride hydrate 通过对鸟氨酸脱羧酶的不可逆抑制作用，抑制多胺生物合成。它是一种化疗保护剂，可阻止血管生成。其生物半衰期为8小时。	Cell,2021, S0092-8674(21)00700-5 Front Cell Infect Microbiol,2020, 16;10:158
S5448	S(-)-Carbidopa S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
S5444	4-Bromo-3-hydroxybenzoic acid 4-bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals.
S5579	Chelidonic acid Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) 是在几种植物中发现的次级代谢产物，对实验动物的过敏性疾病具有治疗潜力。Chelidonic acid 通过阻断HMC-1细胞中的 NF-κB 和 caspase-1 来抑制 IL-6 的产生。Chelidonic acid 也是 glutamate decarboxylase 的抑制剂，其Ki值为1.2 μM。
S5409	Chelidamic acid hydrate Chelidamic acid is a pharmaceutical intermediate as well as a cosmetic material due to its anti-inflammatory and whitening effect. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.