Decarboxylase

抑制剂选择性比较

Decarboxylase产品

目录号 产品描述 文献引用 实验数据
S1891

Carbidopa

Carbidopa 是一种芳香族-L-氨基酸脱羧酶抑制剂,IC50为29±2 μM。

S2453

Benserazide HCl

Benserazide HCl是一种外周性的芳香族L-氨基酸脱羧酶(AAAD)或DOPA脱羧酶抑制剂。

S1642

Methyldopa

Methyldopa 是DOPA 脱羧酶竞争性抑制剂,ED50为21.8 mg/kg。

S0108New

AZ-33

AZ-33 是一种 lactate dehydrogenase A (LDHA) 的有效抑制剂,其IC50值为0.5 μM。LDHA是参与厌氧糖酵解的关键酶,在人类恶性肿瘤中该酶经常失活。

S4582

Eflornithine hydrochloride hydrate

Eflornithine(Difluoromethylornithine)通过对鸟氨酸脱羧酶的不可逆抑制作用,抑制多胺生物合成。它是一种化疗保护剂,可阻止血管生成。其生物半衰期为8小时。

S5448

S(-)-Carbidopa

S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.

S5444

4-Bromo-3-hydroxybenzoic acid

4-bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals.

S5579

Chelidonic acid

Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) 是在几种植物中发现的次级代谢产物,对实验动物的过敏性疾病具有治疗潜力。Chelidonic acid 通过阻断HMC-1细胞中的 NF-κBcaspase-1 来抑制 IL-6 的产生。Chelidonic acid 也是 glutamate decarboxylase 的抑制剂,其Ki值为1.2 μM。

S5409

Chelidamic acid hydrate

Chelidamic acid is a pharmaceutical intermediate as well as a cosmetic material due to its anti-inflammatory and whitening effect. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.

目录号 产品描述 文献引用 实验数据
S1891

Carbidopa

Carbidopa 是一种芳香族-L-氨基酸脱羧酶抑制剂,IC50为29±2 μM。

S2453

Benserazide HCl

Benserazide HCl是一种外周性的芳香族L-氨基酸脱羧酶(AAAD)或DOPA脱羧酶抑制剂。

S1642

Methyldopa

Methyldopa 是DOPA 脱羧酶竞争性抑制剂,ED50为21.8 mg/kg。

S0108New

AZ-33

AZ-33 是一种 lactate dehydrogenase A (LDHA) 的有效抑制剂,其IC50值为0.5 μM。LDHA是参与厌氧糖酵解的关键酶,在人类恶性肿瘤中该酶经常失活。

S4582

Eflornithine hydrochloride hydrate

Eflornithine(Difluoromethylornithine)通过对鸟氨酸脱羧酶的不可逆抑制作用,抑制多胺生物合成。它是一种化疗保护剂,可阻止血管生成。其生物半衰期为8小时。

S5448

S(-)-Carbidopa

S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.

S5444

4-Bromo-3-hydroxybenzoic acid

4-bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals.

S5579

Chelidonic acid

Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxylic acid) 是在几种植物中发现的次级代谢产物,对实验动物的过敏性疾病具有治疗潜力。Chelidonic acid 通过阻断HMC-1细胞中的 NF-κBcaspase-1 来抑制 IL-6 的产生。Chelidonic acid 也是 glutamate decarboxylase 的抑制剂,其Ki值为1.2 μM。

S5409

Chelidamic acid hydrate

Chelidamic acid is a pharmaceutical intermediate as well as a cosmetic material due to its anti-inflammatory and whitening effect. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.

Tags: Decarboxylase inhibition | Decarboxylase pathway | Decarboxylase activation | Decarboxylase inhibitor review