MNK
抑制剂选择性比较
特异性亚型抑制剂
MNK产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
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S6658 |
ETC-206 (AUM 001)ETC-206 (AUM 001, ETC-1907206)是一种可口服、高选择性的MNK 1/2抑制剂,IC50分别为64 nM和86 nM。 |
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S7421 |
CGP 57380CGP 57380 是强效的MNK1抑制剂,其IC50为 2.2 μM,对 p38, JNK1, ERK1 和 -2, PKC, 或 c-Src-like kinases显示无抑制活性。CGP 57380 可上调 β-catenin 并加强辐射诱导的凋亡。 |
![]() ![]() PC-3 cells were seeded in 6-well plates. On the next day, cells were treated with the indicated concentrations of 3-AWA, LY294002, CGP57380 or Rapamycin alone and or combination for 12 h. The cells were then subjected to preparation of whole-cell lysates for detection of the indicated proteins using western blotting. The western blots are the representative of three similar experiments.
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S6888 |
SEL201SEL-201 (SLV-2436, SEL201-88) 是一种高效的、ATP竞争性的 MNK1 和 MNK2 的抑制剂,对应的IC50值分别为10.8 nM和5.4 nM。 |
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S8275 |
Tomivosertib (eFT-508)Tomivosertib (eFT-508) 是一种有效的、选择性的MNK1/2的抑制剂,IC50分别为2.4 nM和1 nM。它能减少肿瘤细胞的增殖和肿瘤生长。Tomivosertib (eFT-508) 可抑制 eIF4E 磷酸化并显着下调 PD-L1 蛋白质的丰度。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S6658 |
ETC-206 (AUM 001)ETC-206 (AUM 001, ETC-1907206)是一种可口服、高选择性的MNK 1/2抑制剂,IC50分别为64 nM和86 nM。 |
||
S7421 |
CGP 57380CGP 57380 是强效的MNK1抑制剂,其IC50为 2.2 μM,对 p38, JNK1, ERK1 和 -2, PKC, 或 c-Src-like kinases显示无抑制活性。CGP 57380 可上调 β-catenin 并加强辐射诱导的凋亡。 |
![]() ![]() PC-3 cells were seeded in 6-well plates. On the next day, cells were treated with the indicated concentrations of 3-AWA, LY294002, CGP57380 or Rapamycin alone and or combination for 12 h. The cells were then subjected to preparation of whole-cell lysates for detection of the indicated proteins using western blotting. The western blots are the representative of three similar experiments.
|
|
S6888 |
SEL201SEL-201 (SLV-2436, SEL201-88) 是一种高效的、ATP竞争性的 MNK1 和 MNK2 的抑制剂,对应的IC50值分别为10.8 nM和5.4 nM。 |
||
S8275 |
Tomivosertib (eFT-508)Tomivosertib (eFT-508) 是一种有效的、选择性的MNK1/2的抑制剂,IC50分别为2.4 nM和1 nM。它能减少肿瘤细胞的增殖和肿瘤生长。Tomivosertib (eFT-508) 可抑制 eIF4E 磷酸化并显着下调 PD-L1 蛋白质的丰度。 |