MNK
- 抑制剂选择性比较
- 溶解性比较
| 目录号 | 产品目录 | 溶解度(25°C) | ||
|---|---|---|---|---|
| 水 | DMSO | 酒精 | ||
| S7421 | CGP 57380 | <1 mg/mL | 48 mg/mL | <1 mg/mL |
| S8275 | eFT-508 (eFT508) | <1 mg/mL | 13 mg/mL | <1 mg/mL |
- MNK抑制剂（2）
| 产品目录 | 产品描述 | 文献引用 | 实验数据 |
|---|---|---|---|
| S7421 |
CGP 57380CGP 57380 是强效的MNK1抑制剂，其IC50为 2.2 μM,对 p38, JNK1, ERK1 和 -2, PKC, 或 c-Src-like kinases显示无抑制活性。 |
PC-3 cells were seeded in 6-well plates. On the next day, cells were treated with the indicated concentrations of 3-AWA, LY294002, CGP57380 or Rapamycin alone and or combination for 12 h. The cells were then subjected to preparation of whole-cell lysates for detection of the indicated proteins using western blotting. The western blots are the representative of three similar experiments.
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| S8275 |
eFT-508 (eFT508)eFT-508 (eFT508)是一种有效的、选择性的MNK1/2的抑制剂，IC50分别为2.4 nM和1 nM。它能减少肿瘤细胞的增殖和肿瘤生长。 |
