MNK

所有产品 MNK抑制剂(3)

目录号	产品描述	文献引用	实验数据
S6658^New	ETC-206 (AUM 001) ETC-206是一种可口服、高选择性的MNK 1/2抑制剂，IC50分别为64 nM和86 nM。
S7421	CGP 57380 CGP 57380 是强效的MNK1抑制剂，其IC50为 2.2 μM,对 p38, JNK1, ERK1 和 -2, PKC, 或 c-Src-like kinases显示无抑制活性。	J Cancer, 2020, 11(4):990-996 Bioorg Med Chem, 2018, 26(16):4602-4614 Cancer Lett, 2016, 10.1016/j.canlet.2016.02.052	PC-3 cells were seeded in 6-well plates. On the next day, cells were treated with the indicated concentrations of 3-AWA, LY294002, CGP57380 or Rapamycin alone and or combination for 12 h. The cells were then subjected to preparation of whole-cell lysates for detection of the indicated proteins using western blotting. The western blots are the representative of three similar experiments.
S8275	Tomivosertib (eFT-508) Tomivosertib (eFT-508)是一种有效的、选择性的MNK1/2的抑制剂，IC50分别为2.4 nM和1 nM。它能减少肿瘤细胞的增殖和肿瘤生长。	Biomolecules, 2019, 10(1) J Pharmacol Exp Ther, 2019, 370(2):219-230

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产品描述

文献引用

实验数据

S6658^New

ETC-206是一种可口服、高选择性的MNK 1/2抑制剂，IC50分别为64 nM和86 nM。

S7421

CGP 57380 是强效的MNK1抑制剂，其IC50为 2.2 μM,对 p38, JNK1, ERK1 和 -2, PKC, 或 c-Src-like kinases显示无抑制活性。

S8275

Tomivosertib (eFT-508)是一种有效的、选择性的MNK1/2的抑制剂，IC50分别为2.4 nM和1 nM。它能减少肿瘤细胞的增殖和肿瘤生长。

目录号	产品描述	文献引用	实验数据
S6658^New	ETC-206 (AUM 001) ETC-206是一种可口服、高选择性的MNK 1/2抑制剂，IC50分别为64 nM和86 nM。
S7421	CGP 57380 CGP 57380 是强效的MNK1抑制剂，其IC50为 2.2 μM,对 p38, JNK1, ERK1 和 -2, PKC, 或 c-Src-like kinases显示无抑制活性。	J Cancer,2020, 11(4):990-996 Bioorg Med Chem,2018, 26(16):4602-4614 Cancer Lett,2016, 10.1016/j.canlet.2016.02.052	PC-3 cells were seeded in 6-well plates. On the next day, cells were treated with the indicated concentrations of 3-AWA, LY294002, CGP57380 or Rapamycin alone and or combination for 12 h. The cells were then subjected to preparation of whole-cell lysates for detection of the indicated proteins using western blotting. The western blots are the representative of three similar experiments.
S8275	Tomivosertib (eFT-508) Tomivosertib (eFT-508)是一种有效的、选择性的MNK1/2的抑制剂，IC50分别为2.4 nM和1 nM。它能减少肿瘤细胞的增殖和肿瘤生长。	Biomolecules,2019, 10(1) J Pharmacol Exp Ther,2019, 370(2):219-230

目录号

产品描述

文献引用

实验数据

S6658^New