MTH1

MTH1产品

目录号	产品描述	文献引用	实验数据
S7505	(S)-crizotinib (S)-crizotinib，crizotinib的(S)型异构体，是一种有效的MTH1 (NUDT1)抑制剂，无细胞试验中IC50为72 nM。	Sci Adv, 2020, 22;6(21):eaaz8521 Cancers (Basel), 2020, 27;12(5)pii: E1087 Cancers (Basel), 2020, 13;12(2) pii: E436	(B) Inhibition of ALK phosphorylation by alectinib in the Ba/F3 cell lines expressing mutated EML4-ALK. Cells were treated with alectinib or crizotinib for 2 h at the indicated concentrations. Phosphorylated ALK (Tyr 1604), ALK, and β-actin were detected by immunoblot analysis using antibodies to each of them.
S7631	TH287 TH287是一种有效的选择性 MTH1 (NUDT1) 抑制剂，IC50 为 0.8 nM。	Mol Cancer Res, 2020, 10.1158/1541-7786.MCR-19-0507 Cancer Biother Radiopharm, 2020, 10.1089/cbr.2019.3031
S7632	TH588 TH588是一种有效的选择性MTH1 (NUDT1)抑制剂，IC50为5 nM。在浓度为100 μM时，对所检测的其他蛋白没有相关抑制作用，但是在10 μM时，对另外一些酶、GPCRs、激酶、离子通道和转运体有一定的选择性。	Cell Syst, 2019, 9(1):74-92.e8 Oncol Lett, 2018, 15(3):3240-3244 Oncol Lett, 2017, 13(4):2161-2168	Square wave voltammograms of C-DNA modified gold electrodes after incubation with different reaction solution that contains (a) active MTH1 (1.0 mg/mL), (b) inactivated MTH1 (1.0 mg/mL), (c) active MTH1 (1.0 mg/mL) with 10 μM TH588 inhibitor, and (d) hOGG1 (5.0 units).

目录号	产品描述	文献引用	实验数据
S7505	(S)-crizotinib (S)-crizotinib，crizotinib的(S)型异构体，是一种有效的MTH1 (NUDT1)抑制剂，无细胞试验中IC50为72 nM。	Sci Adv,2020, 22;6(21):eaaz8521 Cancers (Basel),2020, 27;12(5)pii: E1087 Cancers (Basel),2020, 13;12(2) pii: E436	(B) Inhibition of ALK phosphorylation by alectinib in the Ba/F3 cell lines expressing mutated EML4-ALK. Cells were treated with alectinib or crizotinib for 2 h at the indicated concentrations. Phosphorylated ALK (Tyr 1604), ALK, and β-actin were detected by immunoblot analysis using antibodies to each of them.
S7631	TH287 TH287是一种有效的选择性 MTH1 (NUDT1) 抑制剂，IC50 为 0.8 nM。	Mol Cancer Res,2020, 10.1158/1541-7786.MCR-19-0507 Cancer Biother Radiopharm,2020, 10.1089/cbr.2019.3031
S7632	TH588 TH588是一种有效的选择性MTH1 (NUDT1)抑制剂，IC50为5 nM。在浓度为100 μM时，对所检测的其他蛋白没有相关抑制作用，但是在10 μM时，对另外一些酶、GPCRs、激酶、离子通道和转运体有一定的选择性。	Cell Syst,2019, 9(1):74-92.e8 Oncol Lett,2018, 15(3):3240-3244 Oncol Lett,2017, 13(4):2161-2168	Square wave voltammograms of C-DNA modified gold electrodes after incubation with different reaction solution that contains (a) active MTH1 (1.0 mg/mL), (b) inactivated MTH1 (1.0 mg/mL), (c) active MTH1 (1.0 mg/mL) with 10 μM TH588 inhibitor, and (d) hOGG1 (5.0 units).