Survivin

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研究领域

抑制剂选择性比较

Survivin产品

所有产品 Survivin抑制剂(1)

产品目录	产品描述	文献引用	实验数据
S1130	YM155 (Sepantronium Bromide) YM155 (Sepantronium Bromide)是一种有效的survivin抑制药，通过抑制Survivin启动子活性而发挥作用，在HeLa-SURP-luc 和 CHO-SV40-luc细胞中IC50为0.54 nM；对SV40启动子活性抑制作用不显著，能够轻微抑制Survivin与XIAP相互作用。Phase 2。	Small, 2017, 13(27) Cell Physiol Biochem, 2016, 38(6):2426-37 Oncogenesis, 2016, 10.1038/oncsis.2016.33	MM cell lines UM9 (left panel) or U266 (right panel) were cultured in presence or absence of accessory cells prior to incubation with CTLs alone, YM155 alone or the combination. Survival of UM9 and U266 MM cells was assessed by CS-BLI. Results show % lysis of MM cells after 24 hour incubation and are depicted for three doses.

产品目录

产品描述

文献引用

实验数据

S1130

YM155 (Sepantronium Bromide)

YM155 (Sepantronium Bromide)是一种有效的survivin抑制药，通过抑制Survivin启动子活性而发挥作用，在HeLa-SURP-luc 和 CHO-SV40-luc细胞中IC50为0.54 nM；对SV40启动子活性抑制作用不显著，能够轻微抑制Survivin与XIAP相互作用。Phase 2。

Small, 2017, 13(27)

Cell Physiol Biochem, 2016, 38(6):2426-37

Oncogenesis, 2016, 10.1038/oncsis.2016.33

产品目录	产品描述	文献引用	实验数据
S1130	YM155 (Sepantronium Bromide) YM155 (Sepantronium Bromide)是一种有效的survivin抑制药，通过抑制Survivin启动子活性而发挥作用，在HeLa-SURP-luc 和 CHO-SV40-luc细胞中IC50为0.54 nM；对SV40启动子活性抑制作用不显著，能够轻微抑制Survivin与XIAP相互作用。Phase 2。	Small,2017, 13(27) Cell Physiol Biochem,2016, 38(6):2426-37 Oncogenesis,2016, 10.1038/oncsis.2016.33	MM cell lines UM9 (left panel) or U266 (right panel) were cultured in presence or absence of accessory cells prior to incubation with CTLs alone, YM155 alone or the combination. Survival of UM9 and U266 MM cells was assessed by CS-BLI. Results show % lysis of MM cells after 24 hour incubation and are depicted for three doses.