YM155 (Sepantronium Bromide)

For research use only. Not for use in humans.

目录号:S1130

YM155 (Sepantronium Bromide) Chemical Structure

CAS No. 781661-94-7

YM155 (Sepantronium Bromide)是一种有效的survivin抑制药,通过抑制Survivin启动子活性而发挥作用,在HeLa-SURP-luc 和 CHO-SV40-luc细胞中IC50为0.54 nM;对SV40启动子活性抑制作用不显著,能够轻微抑制Survivin与XIAP相互作用。YM155 在乳腺癌细胞中可下调 survivinXIAP、调节自噬并诱导自噬依赖的DNA损伤。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 918.45 现货
RMB 568.29 现货
RMB 2214.29 现货
RMB 6310.26 现货
RMB 10401.3 现货
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客户使用Selleck生产的YM155 (Sepantronium Bromide)发表文献144篇:

产品安全说明书

Survivin抑制剂选择性比较

生物活性

产品描述 YM155 (Sepantronium Bromide)是一种有效的survivin抑制药,通过抑制Survivin启动子活性而发挥作用,在HeLa-SURP-luc 和 CHO-SV40-luc细胞中IC50为0.54 nM;对SV40启动子活性抑制作用不显著,能够轻微抑制Survivin与XIAP相互作用。YM155 在乳腺癌细胞中可下调 survivinXIAP、调节自噬并诱导自噬依赖的DNA损伤。Phase 2。
靶点
Survivin [1]
(HeLa-SURP-luc, CHO-SV40-luc cells)
0.54 nM
体外研究

YM155 30 μM时对SV40作用效果也不大。在p53缺陷的PC-3和PPC-1 人类HRPC细胞中,通过抑制 survivin基因启动子的转录,YM155显著抑制内源性survivin的表达。相反,YM155 100 nM时对c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, α-actin,及β-tubulin的蛋白表达仍没抑制效果。YM155作用于人类癌细胞系包括PC-3和PPC-1,使细胞发生凋亡,伴随着caspase-3活性上升。YM155有效抑制人类癌细胞系(突变p53或短小p53) 包括PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5及A375 ,IC50值为2.3到11 nM。[1]另外,YM155增强NSCLC细胞对γ-射线的敏感性。YM155和γ-射线联用,增强凋亡细胞数和caspase-3活性。 YM155推迟修复放射诱导核DNA断裂的双链。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Kasumi-1 NGDKWmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX2b5Q1PzJiaB?= M4Tne2ROW09? MYjJR|UxRTBwMEC5JOKyKDBwMECwPUDPxE1? NEC3SFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1PVc{OSd-MkW2OVk4OzF:L3G+
M-07e MkfkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XzclczKGh? MVLEUXNQ NWX4U3VtUUN3ME2wMlA1OCEEsTCwMlAyOyEQvF2= MmG4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N|EoRjJ3NkW5O|MyRC:jPh?=
THP-1 Ml\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLxN2o4OiCq NUXBT5RtTE2VTx?= MmTyTWM2OD1yLkC1NUDDuSByLkCxN{DPxE1? MmTnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N|EoRjJ3NkW5O|MyRC:jPh?=
CMK NUXWcotVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NITtfHY4OiCq M2C2[2ROW09? NFjmUohKSzVyPUCuNFU{KMLzIECuNFA6KM7:TR?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N|E9N2F-
MV4-11 MnvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHhdIM4OiCq MkT2SG1UVw>? NXzJ[5U4UUN3ME2wMlA2PSEEsTCwMlAzQCEQvF2= M{TNTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O|MyLz5{NU[1PVc{OTxxYU6=
AML-193 NEmwN4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo[0O|IhcA>? MXfEUXNQ NUDDSZBmUUN3ME2wMlQ3OiEEsTCwMlA3OCEQvF2= MoDSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N|EoRjJ3NkW5O|MyRC:jPh?=
HL-60 NYjWfZFkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHobY44OiCq MVrEUXNQ NGLpPGlKSzVyPUCuNFAyKMLzIECuNFAxOiEQvF2= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N|E9N2F-
ML-2 NVHCeHZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYflbYJwPzJiaB?= NWfUeY57TE2VTx?= M3HWNmlEPTB;MD6wNFkhyrFiMD6wNFIh|ryP M{PkNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O|MyLz5{NU[1PVc{OTxxYU6=
OCI/AML3 MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVW3NkBp NFfMcJlFVVOR MkW3TWM2OD1yLkCxNUDDuSByLkCwNkDPxE1? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N|E9N2F-
HEL MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XubVczKGh? NX\zWlZCTE2VTx?= M2THUmlEPTB;MD61OVkhyrFiMD6wN|gh|ryP M3vTTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O|MyLz5{NU[1PVc{OTxxYU6=
ME-1 NULDWlY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYq3NkBp MYfEUXNQ M1WwTGlEPTB;MD62PFQhyrFiMD6xO|kh|ryP MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N|E9N2F-
THP-1 Mlr6RZBweHSxc3nzJGF{e2G7 MoixNeKh|ryP M{HrdVczKGh? NVPDVppjTE2VTx?= NVjsbphDcW6mdXPld{BieG:ydH;zbZM> Mlz6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N|EoRjJ3NkW5O|MyRC:jPh?=
M-07e NYX1SZJSTnWwY4Tpc44hSXO|YYm= M1uyfFDjiJNzwrFOwG0> MXe3NkBp MknpSG1UVw>? M1v2Zolv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gV5Vzfmm4aX6= MmDSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N|EoRjJ3NkW5O|MyRC:jPh?=
THP-1 NF7oeItHfW6ldHnvckBCe3OjeR?= MnjqNQKBmzIEoN88US=> NW\KO3ByPzJiaB?= NGLBO2VFVVOR NX;YXWticW6mdXPld{Bld3ewcnXneYxifGmxbjDv[kBUfXK4aY\pci=> NGLhU4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1PVc{OSd-MkW2OVk4OzF:L3G+
CMK M4nQXWZ2dmO2aX;uJGF{e2G7 NGXZWIcx6oDVMdMg{txO MVK3NkBp NXjiWJZSTE2VTx?= M3zQeolv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gV5Vzfmm4aX6= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N|E9N2F-
AML-193 M4fVT2Z2dmO2aX;uJGF{e2G7 MWew5qCUOcLizszN M1:5UFczKGh? MV;EUXNQ Mk\lbY5lfWOnczDkc5dvemWpdXzheIlwdiCxZjDTeZJ3cX[rbh?= NYnoW21jRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVk4OzFpPkK1OlU6PzNzPD;hQi=>
Kasumi-1 NUXBVmxZTnWwY4Tpc44hSXO|YYm= MWew5qCUOcLizszN MnzSO|IhcA>? NF31b2xFVVOR M2nOcolv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gV5Vzfmm4aX6= MnG3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N|EoRjJ3NkW5O|MyRC:jPh?=
MV4-11 M1myOWZ2dmO2aX;uJGF{e2G7 NVP1XoFOOOLCk{JCpO69VQ>? MX:3NkBp M4\XZ2ROW09? MnrUbY5lfWOnczDkc5dvemWpdXzheIlwdiCxZjDTeZJ3cX[rbh?= NIDt[I09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1PVc{OSd-MkW2OVk4OzF:L3G+
MUG-Chor  NX;YXWNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXPNE02KM7:TR?= MXeyOE81QCCq NInweXJKSzVyPUeuNFXjiImwTTDmc5IhPDiq M2fhflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkSwNVg2Lz5{NU[0NFE5PTxxYU6=
U-CH1  NHj0VlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETieW0xNTVizszN M4LrdlI1NzR6IHi= M1HSOWlEPTB;OT6wN-KBkW6PIH\vdkA1QGh? NHHaSHA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[0NFE5PSd-MkW2OFAyQDV:L3G+
KATOIII NXnVc|RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LYR|ExNzJyIH7N M1LwNFQ5KGh? NYj2eJN7cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NYXnfYhDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2N|UxPTVpPkK1OlM2ODV3PD;hQi=>
AGS  M3jXRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzEUnQyOC9{MDDuUS=> NFHnT2M1QCCq MUDpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MlXaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4M{WwOVUoRjJ3NkO1NFU2RC:jPh?=
SACC-83 MmTkSpVv[3Srb36gRZN{[Xl? NGjkeYo2KG6P NIPLU|g1QCCq NIjTT|Nl\WO{ZXHz[ZMhdnWlbHXhdkBmgHC{ZYPzbY9vKG:oIFjJSk0y|rF? NETPO2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUS4OVY{PSd-MkW0PFU3OzV:L3G+
INA-6 M{TJ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\nNE02ODBibl2= MWC0PEBp MVvpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NVHMSlZpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyPVY6PzhpPkK1Nlk3QTd6PD;hQi=>
U-266 NWTL[3RVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1T6TVAuPTByIH7N MXi0PEBp M2HVfYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NF25ZpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK5Olk4QCd-MkWyPVY6Pzh:L3G+
MOLP-8 M1rIXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrINE02ODBibl2= NHHMTGc1QCCq NHn4WndqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MmrSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{OU[5O|goRjJ3Mkm2PVc5RC:jPh?=
HG-1 NInMUIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NETzRYsxNTVyMDDuUS=> MXq0PEBp NVrpVXU4cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? MlTsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{OU[5O|goRjJ3Mkm2PVc5RC:jPh?=
NCI-H929 Mn3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHoNE02ODBibl2= NXHB[4l6PDhiaB?= M2O4bIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NUHaV5pHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyPVY6PzhpPkK1Nlk3QTd6PD;hQi=>
OPM-2 MoDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkL6NE02ODBibl2= M3L3[|Q5KGh? MXPpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NGXId4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK5Olk4QCd-MkWyPVY6Pzh:L3G+
L-363 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HR[VAuPTByIH7N NFL0ZnA1QCCq MnPhbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ7Nkm3PEc,OjV{OU[5O|g9N2F-
MOLP-2 NGDKOWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUewMVUxOCCwTR?= NFPTWo41QCCq M2XzTYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz NEnOO3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK5Olk4QCd-MkWyPVY6Pzh:L3G+
KMS-12-BM M1nXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWCwMVUxOCCwTR?= NVSwRZhFPDhiaB?= NIm3VZdqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NF6yeXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK5Olk4QCd-MkWyPVY6Pzh:L3G+
SK-MM-2 M{jXWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXiwMVUxOCCwTR?= MYO0PEBp MWTpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MmHLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{OU[5O|goRjJ3Mkm2PVc5RC:jPh?=
U-266 MnHxRZBweHSxc3nzJGF{e2G7 NYXzXlZOOC13MDDuUS=> MYCyOEBp NX\ydpVTcW6mdXPld{BieG:ydH;zbZM> NUWxd21FRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyPVY6PzhpPkK1Nlk3QTd6PD;hQi=>
INA-6  MnzyRZBweHSxc3nzJGF{e2G7 M4nPc|AuPTBibl2= MVqyOEBp M3LSdIlv\HWlZYOgZZBweHSxc3nz NUnENGRtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyPVY6PzhpPkK1Nlk3QTd6PD;hQi=>
MCF7 M{D1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWW4bpNqPzJiaB?= M{\nOGlEPTB;MUOgxtEhPiCwTR?= NHzWe4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKyNFIzPSd-MkWyNlAzOjV:L3G+
MCF7-TamR6 MoPHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjjVZZjPzJiaB?= MX7JR|UxRThiwsGgOkBvVQ>? NX25T3d{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNlAzOjVpPkK1NlIxOjJ3PD;hQi=>
MCF7-TamR7 M4nWbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGqzNJI4OiCq NX7ROZgzUUN3ME24JOKyKDNibl2= NXf2R3Q{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNlAzOjVpPkK1NlIxOjJ3PD;hQi=>
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RD-ES M1fZcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{X6SFAvOS1zMECwJI5O NIXZd2NGSzVyPU[uNkBvVSxiaX7obYJqfHNiY3XscEBoem:5dHigbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wZYK= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl4MUe2N{c,OjJ7NkG3OlM9N2F-
HEK293 M1\GT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PKPFAvOS1zMECwJI5O NVfGSYZITUN3ME2yN{4xKG6PLDDpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M2jUVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OU[xO|Y{Lz5{Mkm2NVc3OzxxYU6=
M059J MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDJcIIxNTVyIH7N NF\U[Fc1QCCq NUXlSIRncW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd5MEGxNEc,OjJ5N{CxNVA9N2F-
M059K MkPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELNSGExNTVyIH7N NX3CTXo1PDhiaB?= MUnpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NYi4UlQ5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3O|AyOTBpPkKyO|cxOTFyPD;hQi=>
M059J M2HnNmFxd3C2b4Ppd{BCe3OjeR?= NWrrcowxOzBibl2= NEfZNmozPCCq M2DVb4lv\HWlZYOgZZBweHSxc3nz NEjpSpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke3NFEyOCd-MkK3O|AyOTB:L3G+
M059K MU\BdI9xfG:|aYOgRZN{[Xl? M{DUN|MxKG6P NV;lPIluOjRiaB?= NGDQVYlqdmS3Y3XzJIFxd3C2b4Ppdy=> NEXQT5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke3NFEyOCd-MkK3O|AyOTB:L3G+
PANC-1 NFK1VIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPUfoExNjBzLUGwNFAhdk1? M1nrUVQ5KGh? NYTPS2F6UUN3ME2zMlY6KG6P NFfFfZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyN|g4OSd-MkK3NlM5PzF:L3G+
MIAPaCa-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX[wMlAyNTFyMECgcm0> NG[3OIM1QCCq M3HzdmlEPTB;MkmuN|Yhdk1? M4X2[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{KzPFcyLz5{MkeyN|g4OTxxYU6=
BxPC-3 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPJNE4xOS1zMECwJI5O NYKwZYEyPDhiaB?= M4HRbGlEPTB;M{CuNlYhdk1? MljFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5MkO4O|EoRjJ{N{KzPFcyRC:jPh?=
PANC-1 MUDGeY5kfGmxbjDBd5NigQ>? MlnPNE0yODByIH7N M3nvO|I1KGh? NWrEN4JbcW6mdXPld{Bld3ewcnXneYxifGmxbjDv[kBZUUGSIHHu[EB{fXK4aY\pckBmgHC{ZYPzbY9v MlS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5MkO4O|EoRjJ{N{KzPFcyRC:jPh?=
MIAPaCa-2 MYnGeY5kfGmxbjDBd5NigQ>? M2TlPFAuOTByMDDuUS=> NEGwcZAzPCCq M2PqWYlv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gXGlCWCCjbnSgd5Vzfmm4aX6g[ZhxemW|c3nvci=> MojsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5MkO4O|EoRjJ{N{KzPFcyRC:jPh?=
BxPC-3 MXPGeY5kfGmxbjDBd5NigQ>? NYW4PGVMOC1zMECwJI5O Moi5NlQhcA>? NH;keVdqdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJHhKSVBiYX7kJJN2en[rdnnuJIV5eHKnc4Ppc44> M3PlXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{KzPFcyLz5{MkeyN|g4OTxxYU6=
RPMI-7951 M3XmXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTsS5Z{T0l3ME2zMlIhdk1? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd|N{WwNkc,OjF5M{e1NFI9N2F-
SK-MEL-5 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzPS2k2OD12LkKgcm0> MoXqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5M{e1NFIoRjJzN{O3OVAzRC:jPh?=
A375 NGfWRmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmGxS2k2OD14LkOgcm0> NVHkTGtPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3N|c2ODJpPkKxO|M4PTB{PD;hQi=>
SK-MEL-28 M{nNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmOyS2k2OD15Lk[gcm0> M{LDUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{O3OVAzLz5{MUezO|UxOjxxYU6=
SK-MEL-2 NFrZSFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jtdGdKPTB;MUGgcm0> NW\wV2tyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG3N|c2ODJpPkKxO|M4PTB{PD;hQi=>
DB M3LtRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYGxS2NGPDkEoHi= MYDHTVUxRTNwNTDuUS=> M3\0N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkO3OVA5Lz5{MUKzO|UxQDxxYU6=
Pfeiffer MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUG0POKhcA>? NX7DNlJtT0l3ME2zMlkhdk1? NHHXSG49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUKzO|UxQCd-MkGyN|c2ODh:L3G+
SU-DHL-5 NVLoNYZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mli3OFjDqGh? M{\veGdKPTB;MD6yN{BvVQ>? NFfTc4Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUKzO|UxQCd-MkGyN|c2ODh:L3G+
SU-DHL-8 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV22R3I5PDkEoHi= NH;2SpRIUTVyPUGuOEBvVQ>? M3XmTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkO3OVA5Lz5{MUKzO|UxQDxxYU6=
WSU-DLCL-2 NWn2d20xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfjdYY1QMLiaB?= NXfXe|c2T0l3ME2xMlQhdk1? MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ|N{WwPEc,OjF{M{e1NFg9N2F-
A549 M2XLWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2DIdWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGE2PDliY3XscJMtKEmFNUC9NE4xOTN2zszN MlmzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6MUSzO|QoRjJ6OEG0N|c1RC:jPh?=
DU145 MYLDfZRwfG:6aXPpeJkh[XO|YYm= NEfpb4REgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCkeTDNWHQh[XO|YYmsJGVEPTB;MD6wNVM5|ryP MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd5NESyOkc,Ojh5N{S0NlY9N2F-
PC3 NV;nNWVQS3m2b4TvfIlkcXS7IHHzd4F6 NHi5cIlEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[nliTWTUJIF{e2G7LDDFR|UxRTBwMEmy{txO MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd5NESyOkc,Ojh5N{S0NlY9N2F-
A549 NH:5eWNHfW6ldHnvckBie3OjeR?= M2C0UmlvcGmkaYTpc44hd2ZiUFHLNUBqdiCqdX3hckBCPTR7IHPlcIx{NCCLQ{WwQVAvPc7:TR?= NGL6NVI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEixOFM4PCd-Mki4NVQ{PzR:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Survivin / XIAP / Caspase-7 / Caspase-9 / Caspase-3 / Cleaved Caspase-8 / PARP; 

PubMed: 26771139     


YM155 treatment decreased survivin expression without affecting XIAP and induced cleavage of caspases. Protein expression (caspase-3, -7, -9, -8, PARP) was detected by Western Blot analysis. 

β-catenin / c-Myc / Cyclin D1 / CD44 ; 

PubMed: 26771139     


YM155 inhibited expression of CSC molecules. SGC-7901 cells were treated with YM155 at indicated doses for 24 hours. The protein levels of genes were determined by Western Blot.

p-STAT3 / STAT3 ; 

PubMed: 22723871     


Levels of phosphorylated STAT3 and expression of survivin were analyzed by Western blotting after a 24-hours treatment with YM155 and 48 hours after transfection of 40 nM siRNA.

26771139 22723871
Immunofluorescence
EGFR; 

PubMed: 22723871     


YM155 (10 nM) induced the nuclear EGFR accumulation. PANC-1 cells were stained with anti-EGFR, anti-Alexa Fluor 488, and DAPI after the YM155 treatment. Scale bars: 10 µm.

PARP-1 / PAR ; 

PubMed: 26090615     


A. Nuclear accumulation of active PARP-1 in KYSE410 cells after 12 h of YM155 treatment was evaluated using immunofluorescent analysis. Nuclei were stained with DAPI, as shown in blue. Scale bars: 10 μm. C. Accumulation of the poly-ADP polymer in KYSE410 was evaluated using immunofluorescent analysis after YM155 treatment for 12 h. Nuclei were stained with DAPI, as shown in blue. Scale bars: 10 μm. 

22723871 26090615
Growth inhibition assay
Cell viability; 

PubMed: 29636860     


Cells were grown in 96-well plates for 24 h and treated with the indicated concentrations of YM155 or docetaxel for 72 h, and cell survival was determined by MTT assay.

29636860
体内研究 YM155按3和10 mg/kg皮下注射前列腺移植瘤,结果显示YM155完全抑制PC-3的肿瘤生长,但是重量没有降低,血细胞数也没有下降。药物动力学分析显示YM155作用于肿瘤组织效果很明显。而且,YM155按5 mg/kg作用于PC-3常位移植瘤时肿瘤抑制率达80% 。[1]YM155和γ-射线联用作用于携带H460或Calu6 移植瘤的裸鼠,显示出强抗癌活性。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

启动子-荧光酶素报告实验:

使用Pyrobest聚合酶和引物5’-GCGCGCTCGAGTCTAGACATGCGGATATATTC-3’和5’-GCGCGAA-GCTTTGGCGGTTAATGGCGCGC-3’, 从人类基因组DNA中分离2767个碱基对序列的人类survivin基因启动子。在pGL3-Basic质粒的XhoI/HindIII切除位点,内切酶XhoI/HindIII切除产生的PCR片段。产生的质粒称为pSUR-luc。通过DNA测序仪在所有增强序列处测定DNA序列。通过荧光酶素实验,使用短暂转染的HeLa-S3细胞,测定pSUR-luc的活力。使用的pGL3质粒含有SV40启动子和增强子序列。 pSUR-luc和pSV2bsr 质粒通过Lipofectamin2000稳定转染到HeLa细胞中。加入10 μg/mL灭瘟素,根据适当的荧光酶素信号和基因稳定性,筛选HeLa-SURP-luc单一群落。pGL3和pSV2bsr质粒稳定转染到CHO细胞中。加入10 μg/mL灭瘟素,根据适当的荧光酶素信号和基因稳定性,筛选CHO-SV40-luc单一群落。从HeLa-SURP-luc和CHO-SV40-luc群落中获得细胞用于化学筛选。细胞按每孔5×103接种在96孔板上,加入YM155(溶于DMSO中)。24小时后测定荧光酶素活性。通过回归分析计算IC50值。
细胞实验:

[1]

- 合并
  • Cell lines: PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5,和A375细胞
  • Concentrations: ~ 100 nM
  • Incubation Time: 48小时
  • Method:

    PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5,及A375细胞系按5到40×103密度接种在96孔板上。YM155溶解在DMSO中,持续处理细胞48小时。通过sulforhodamine B试剂测定细胞数。


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: 皮下注射PC-3移植瘤的雄性裸鼠(BALB/c nu/nu)
  • Dosages: 5 mg/kg
  • Administration: 皮下注射,每周持续处理3天,处理3周。
    (Only for Reference)

溶解度 (25°C)

体外 Water 89 mg/mL (200.77 mM)
DMSO 55 mg/mL (124.07 mM)
Ethanol 6 mg/mL (13.53 mM)
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 443.29
化学式

C20H19BrN4O3

CAS号 781661-94-7
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、SDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01023386 Completed Drug: YM155 Cancer Astellas Pharma Inc November 2009 Phase 1

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在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

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Survivin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID