YM155 (Sepantronium Bromide)

For research use only. Not for use in humans.

目录号：S1130

YM155 (Sepantronium Bromide) Chemical Structure

CAS No. 781661-94-7

YM155 (Sepantronium Bromide)是一种有效的survivin抑制药，通过抑制Survivin启动子活性而发挥作用，在HeLa-SURP-luc 和 CHO-SV40-luc细胞中IC50为0.54 nM；对SV40启动子活性抑制作用不显著，能够轻微抑制Survivin与XIAP相互作用。YM155 在乳腺癌细胞中可下调 survivin 和 XIAP、调节自噬并诱导自噬依赖的DNA损伤。Phase 2。

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价格

库存

购买数量

10mM (1mL in DMSO)	RMB 918.45	现货
5mg	RMB 568.29	现货
10mg	RMB 983.81	现货
25mg	RMB 2214.29	现货
100mg	RMB 6310.26	现货
200mg	RMB 10401.3	现货
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客户使用Selleck生产的YM155 (Sepantronium Bromide)发表文献133篇：

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产品安全说明书

Survivin抑制剂选择性比较

生物活性

产品描述

靶点

Survivin ^[1]
(HeLa-SURP-luc, CHO-SV40-luc cells)

0.54 nM

体外研究

YM155 30 μM时对SV40作用效果也不大。在p53缺陷的PC-3和PPC-1 人类HRPC细胞中，通过抑制 survivin基因启动子的转录，YM155显著抑制内源性survivin的表达。相反，YM155 100 nM时对c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, α-actin,及β-tubulin的蛋白表达仍没抑制效果。YM155作用于人类癌细胞系包括PC-3和PPC-1，使细胞发生凋亡，伴随着caspase-3活性上升。YM155有效抑制人类癌细胞系(突变p53或短小p53) 包括PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5及A375 ，IC50值为2.3到11 nM。^[1]另外，YM155增强NSCLC细胞对γ-射线的敏感性。YM155和γ-射线联用，增强凋亡细胞数和caspase-3活性。 YM155推迟修复放射诱导核DNA断裂的双链。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
Kasumi-1	Mln1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NYPoXphUPzJiaB?=	MonnSG1UVw>?	MmPLTWM2OD1yLkCwPUDDuSByLkCwNFkh\|ryP	Mn7DNlU3PTl5M{G=
M-07e	MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		Mo\4O\|IhcA>?	MlHySG1UVw>?	NYTQcIh1UUN3ME2wMlA1OCEEsTCwMlAyOyEQvF2=	NHrtW5YzPTZ3OUezNS=>
THP-1	MoX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MVe3NkBp	MVrEUXNQ	Mo\1TWM2OD1yLkC1NUDDuSByLkCxN{DPxE1?	NFPpUHAzPTZ3OUezNS=>
CMK	MmL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NHXzVY44OiCq	MVnEUXNQ	MWrJR\|UxRTBwMEWzJOKyKDBwMEC5JO69VQ>?	MnH5NlU3PTl5M{G=
MV4-11	NHjvUVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NVK3RY1xPzJiaB?=	NGj4OmVFVVOR	NFnPU4JKSzVyPUCuNFU2KMLzIECuNFI5KM7:TR?=	M1;n[\|I2PjV7N{Ox
AML-193	NX20R2hUT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M13yS\|czKGh?	Mn7ISG1UVw>?	NE[5UGZKSzVyPUCuOFYzKMLzIECuNFYxKM7:TR?=	NFjk[4kzPTZ3OUezNS=>
HL-60	NVrLVpdzT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MYC3NkBp	NVLDZ25MTE2VTx?=	MXvJR\|UxRTBwMECxJOKyKDBwMECwNkDPxE1?	MY[yOVY2QTd\|MR?=
ML-2	MoLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NWG5bmpNPzJiaB?=	MnPwSG1UVw>?	M2[3bmlEPTB;MD6wNFkhyrFiMD6wNFIh\|ryP	NGe5UFIzPTZ3OUezNS=>
OCI/AML3	MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MkfiO\|IhcA>?	MX3EUXNQ	MkH2TWM2OD1yLkCxNUDDuSByLkCwNkDPxE1?	NV65OoVMOjV4NUm3N\|E>
HEL	NYjjXpN6T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MkjMO\|IhcA>?	M3rhRmROW09?	M4XkTGlEPTB;MD61OVkhyrFiMD6wN\|gh\|ryP	NXv4bI12OjV4NUm3N\|E>
ME-1	NHWzZm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MUO3NkBp	MYDEUXNQ	M1XvPGlEPTB;MD62PFQhyrFiMD6xO\|kh\|ryP	MkDENlU3PTl5M{G=
THP-1	MWrBdI9xfG:\|aYOgRZN{[Xl?	MXGxxsDPxE1?	MXi3NkBp	MYLEUXNQ	MV\pcoR2[2W\|IHHwc5B1d3Orcx?=	NYTQeoxDOjV4NUm3N\|E>
M-07e	Ml\zSpVv[3Srb36gRZN{[Xl?	NIjzUGgx6oDVMdMg{txO	MoPmO\|IhcA>?	M4fLXmROW09?	NVnrc4xjcW6mdXPld{Bld3ewcnXneYxifGmxbjDv[kBUfXK4aY\pci=>	MoPkNlU3PTl5M{G=
THP-1	MVXGeY5kfGmxbjDBd5NigQ>?	M2jpNlDjiJNzwrFOwG0>	Mn;CO\|IhcA>?	NVXzeVg1TE2VTx?=	NEnucVJqdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJHN2en[rdnnu	MmnKNlU3PTl5M{G=
CMK	NFLqW2tHfW6ldHnvckBCe3OjeR?=	NIr3NGUx6oDVMdMg{txO	NYrXWHZJPzJiaB?=	M1fWVWROW09?	MWXpcoR2[2W\|IHTve45z\We3bHH0bY9vKG:oIGP1dpZqfmmw	M3Pj[FI2PjV7N{Ox
AML-193	MXrGeY5kfGmxbjDBd5NigQ>?	NHjES4Ix6oDVMdMg{txO	NEHiWZo4OiCq	M3Ln[GROW09?	MVfpcoR2[2W\|IHTve45z\We3bHH0bY9vKG:oIGP1dpZqfmmw	NYnEN2RkOjV4NUm3N\|E>
Kasumi-1	MWPGeY5kfGmxbjDBd5NigQ>?	Mn7sNQKBmzIEoN88US=>	NVzoRWVTPzJiaB?=	M4LpfmROW09?	M2jKSYlv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gV5Vzfmm4aX6=	NHnOUW4zPTZ3OUezNS=>
MV4-11	NIfuSIJHfW6ldHnvckBCe3OjeR?=	NIjyVWYx6oDVMdMg{txO	M2XVRVczKGh?	MVjEUXNQ	NF;uN3NqdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJHN2en[rdnnu	NXP0fHNMOjV4NUm3N\|E>
MUG-Chor	MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NVPKc\|JDOC13IN88US=>	NInZb5czPC92ODDo		Ml\NTWM2OD15LkC15qCKdk1iZn;yJFQ5cA>?	MXKyOVY1ODF6NR?=
U-CH1	NYO2c5k5T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MXWwMVUh\|ryP	MoHqNlQwPDhiaB?=		NW\HXVdwUUN3ME25MlA{6oDLbl2g[o9zKDR6aB?=	MUKyOVY1ODF6NR?=
KATOIII	MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnrWNVAwOjBibl2=	Moe4OFghcA>?		NVL3cnVYcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ?	NGXZXm8zPTZ\|NUC1OS=>
AGS	M1m4PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1HZcFExNzJyIH7N	M2DmRlQ5KGh?		NUjoeoU3cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ?	MmfONlU3OzVyNUW=
SACC-83	MVfGeY5kfGmxbjDBd5NigQ>?	M2G1VFUhdk1?	NITmUng1QCCq		Ml:x[IVkemWjc3XzJI52[2ynYYKg[ZhxemW\|c3nvckBw\iCKSV[tNe6y	MXuyOVQ5PTZ\|NR?=
INA-6	M3fRZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MYGwMVUxOCCwTR?=	NUnVfIlGPDhiaB?=		MXjpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=>	MVmyOVI6Pjl5OB?=
U-266	NUPZPZBKT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NXvOdIhYOC13MECgcm0>	NFv1WXM1QCCq		NFnxRpBqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>?	MWiyOVI6Pjl5OB?=
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MIAPaCa-2	M{DlRWZ2dmO2aX;uJGF{e2G7	MVmwMVExODBibl2=	Mm\6NlQhcA>?		NWfjdHJ4cW6mdXPld{Bld3ewcnXneYxifGmxbjDv[kBZUUGSIHHu[EB{fXK4aY\pckBmgHC{ZYPzbY9v	NWXlS2hPOjJ5MkO4O\|E>
BxPC-3	NFj4RZhHfW6ldHnvckBCe3OjeR?=	NEDJd40xNTFyMECgcm0>	MYiyOEBp		MWLpcoR2[2W\|IHTve45z\We3bHH0bY9vKG:oIGjJRXAh[W6mIIP1dpZqfmmwIHX4dJJme3Orb36=	NFjNNFQzOjd{M{i3NS=>
RPMI-7951	NH7tVZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				MkK1S2k2OD1\|LkKgcm0>	MXWyNVc{PzVyMh?=
SK-MEL-5	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?				M4m5NmdKPTB;ND6yJI5O	Ml7jNlE4Ozd3MEK=
A375	Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MnvWS2k2OD14LkOgcm0>	NX:5fJhwOjF5M{e1NFI>
SK-MEL-28	MkDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NHLvRWRIUTVyPUeuOkBvVQ>?	M1ywdFIyPzN5NUCy
SK-MEL-2	NFLqUYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M2LuWmdKPTB;MUGgcm0>	MonrNlE4Ozd3MEK=
DB	NFnQWm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M3H3fFQ5yqCq		MlfRS2k2OD1\|LkWgcm0>	M2HQVFIyOjN5NUC4
Pfeiffer	M3LDTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M1;oc\|Q5yqCq		MXrHTVUxRTNwOTDuUS=>	MorMNlEzOzd3MEi=
SU-DHL-5	NUjaOGFOT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M2rkVlQ5yqCq		Mnu5S2k2OD1yLkKzJI5O	NVXPUpczOjF{M{e1NFg>
SU-DHL-8	M33zTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NUDvTpprPDkEoHi=		MkPaS2k2OD1zLkSgcm0>	NXLlTIJQOjF{M{e1NFg>
WSU-DLCL-2	NIPqb5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NGPHOVM1QMLiaB?=		MmDaS2k2OD1zLkSgcm0>	NUjsb2I5OjF{M{e1NFg>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Survivin / XIAP / Caspase-7 / Caspase-9 / Caspase-3 / Cleaved Caspase-8 / PARP; PubMed: 26771139 Oncotarget YM155 treatment decreased survivin expression without affecting XIAP and induced cleavage of caspases. Protein expression (caspase-3, -7, -9, -8, PARP) was detected by Western Blot analysis. β-catenin / c-Myc / Cyclin D1 / CD44 ; PubMed: 26771139 Oncotarget YM155 inhibited expression of CSC molecules. SGC-7901 cells were treated with YM155 at indicated doses for 24 hours. The protein levels of genes were determined by Western Blot. p-STAT3 / STAT3 ; PubMed: 22723871 PLoS One Levels of phosphorylated STAT3 and expression of survivin were analyzed by Western blotting after a 24-hours treatment with YM155 and 48 hours after transfection of 40 nM siRNA.	26771139 22723871
Immunofluorescence	EGFR; PubMed: 22723871 PLoS One YM155 (10 nM) induced the nuclear EGFR accumulation. PANC-1 cells were stained with anti-EGFR, anti-Alexa Fluor 488, and DAPI after the YM155 treatment. Scale bars: 10 µm. PARP-1 / PAR ; PubMed: 26090615 Oncotarget A. Nuclear accumulation of active PARP-1 in KYSE410 cells after 12 h of YM155 treatment was evaluated using immunofluorescent analysis. Nuclei were stained with DAPI, as shown in blue. Scale bars: 10 μm. C. Accumulation of the poly-ADP polymer in KYSE410 was evaluated using immunofluorescent analysis after YM155 treatment for 12 h. Nuclei were stained with DAPI, as shown in blue. Scale bars: 10 μm.	22723871 26090615
Growth inhibition assay	Cell viability; PubMed: 29636860 Am J Transl Res Cells were grown in 96-well plates for 24 h and treated with the indicated concentrations of YM155 or docetaxel for 72 h, and cell survival was determined by MTT assay.	29636860

体内研究

YM155按3和10 mg/kg皮下注射前列腺移植瘤，结果显示YM155完全抑制PC-3的肿瘤生长，但是重量没有降低，血细胞数也没有下降。药物动力学分析显示YM155作用于肿瘤组织效果很明显。而且，YM155按5 mg/kg作用于PC-3常位移植瘤时肿瘤抑制率达80% 。^[1]YM155和γ-射线联用作用于携带H460或Calu6 移植瘤的裸鼠，显示出强抗癌活性。^[2]

激酶实验： ^[1]	- 合并启动子-荧光酶素报告实验: 使用Pyrobest聚合酶和引物5’-GCGCGCTCGAGTCTAGACATGCGGATATATTC-3’和5’-GCGCGAA-GCTTTGGCGGTTAATGGCGCGC-3’，从人类基因组DNA中分离2767个碱基对序列的人类survivin基因启动子。在pGL3-Basic质粒的XhoI/HindIII切除位点，内切酶XhoI/HindIII切除产生的PCR片段。产生的质粒称为pSUR-luc。通过DNA测序仪在所有增强序列处测定DNA序列。通过荧光酶素实验，使用短暂转染的HeLa-S3细胞，测定pSUR-luc的活力。使用的pGL3质粒含有SV40启动子和增强子序列。 pSUR-luc和pSV2bsr 质粒通过Lipofectamin2000稳定转染到HeLa细胞中。加入10 μg/mL灭瘟素，根据适当的荧光酶素信号和基因稳定性，筛选HeLa-SURP-luc单一群落。pGL3和pSV2bsr质粒稳定转染到CHO细胞中。加入10 μg/mL灭瘟素，根据适当的荧光酶素信号和基因稳定性，筛选CHO-SV40-luc单一群落。从HeLa-SURP-luc和CHO-SV40-luc群落中获得细胞用于化学筛选。细胞按每孔5×10³接种在96孔板上，加入YM155（溶于DMSO中）。24小时后测定荧光酶素活性。通过回归分析计算IC50值。
细胞实验： ^[1]	- 合并 Cell lines: PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5，和A375细胞 Concentrations: ~ 100 nM Incubation Time: 48小时 Method: PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5，及A375细胞系按5到40×10³密度接种在96孔板上。YM155溶解在DMSO中，持续处理细胞48小时。通过sulforhodamine B试剂测定细胞数。 (Only for Reference)
动物实验： ^[1]	- 合并 Animal Models: 皮下注射PC-3移植瘤的雄性裸鼠(BALB/c nu/nu) Dosages: 5 mg/kg Administration: 皮下注射，每周持续处理3天，处理3周。 (Only for Reference)

参考文献

溶解度 (25°C)

体外	Water	89 mg/mL (200.77 mM)
	DMSO	55 mg/mL (124.07 mM)
	Ethanol	6 mg/mL (13.53 mM)
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： Saline	30 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download YM155 (Sepantronium Bromide) SDF

分子量	443.29
化学式	C₂₀H₁₉BrN₄O₃
CAS号	781661-94-7
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、MSDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

研究领域

产品类型

定制您的化合物库

YM155 (Sepantronium Bromide)

客户使用Selleck生产的YM155 (Sepantronium Bromide)发表文献133篇：

产品安全说明书

Survivin抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download YM155 (Sepantronium Bromide) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

技术支持

Survivin Signaling Pathway Map

相关Survivin产品