YM155 (Sepantronium Bromide)

For research use only. Not for use in humans.

目录号：S1130

YM155 (Sepantronium Bromide) Chemical Structure

CAS No. 781661-94-7

YM155 (Sepantronium Bromide)是一种有效的survivin抑制药，通过抑制Survivin启动子活性而发挥作用，在HeLa-SURP-luc 和 CHO-SV40-luc细胞中IC50为0.54 nM；对SV40启动子活性抑制作用不显著，能够轻微抑制Survivin与XIAP相互作用。YM155 在乳腺癌细胞中可下调 survivin 和 XIAP、调节自噬并诱导自噬依赖的DNA损伤。Phase 2。

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库存

购买数量

10mM (1mL in DMSO)	RMB 918.45	现货
5mg	RMB 568.29	现货
25mg	RMB 2214.29	现货
100mg	RMB 6310.26	现货
200mg	RMB 10401.3	现货
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客户使用Selleck生产的YM155 (Sepantronium Bromide)发表文献151篇：

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产品安全说明书

Survivin抑制剂选择性比较

生物活性

产品描述

靶点

Survivin ^[1]
(HeLa-SURP-luc, CHO-SV40-luc cells)

0.54 nM

体外研究

YM155 30 μM时对SV40作用效果也不大。在p53缺陷的PC-3和PPC-1 人类HRPC细胞中，通过抑制 survivin基因启动子的转录，YM155显著抑制内源性survivin的表达。相反，YM155 100 nM时对c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, α-actin,及β-tubulin的蛋白表达仍没抑制效果。YM155作用于人类癌细胞系包括PC-3和PPC-1，使细胞发生凋亡，伴随着caspase-3活性上升。YM155有效抑制人类癌细胞系(突变p53或短小p53) 包括PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5及A375 ，IC50值为2.3到11 nM。^[1]另外，YM155增强NSCLC细胞对γ-射线的敏感性。YM155和γ-射线联用，增强凋亡细胞数和caspase-3活性。 YM155推迟修复放射诱导核DNA断裂的双链。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID
Kasumi-1	MljkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MVW3NkBp	M4HsOmROW09?	NXi4UXpnUUN3ME2wMlAxQSEEsTCwMlAxODlizszN	M3;tPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O\|MyLz5{NU[1PVc{OTxxYU6=
M-07e	Ml;rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MorEO\|IhcA>?	NFjBenRFVVOR	NV7jb2JSUUN3ME2wMlA1OCEEsTCwMlAyOyEQvF2=	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N\|E9N2F-
THP-1	M1HqTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		NYP2SpY5PzJiaB?=	NGfJVnpFVVOR	M2\YbmlEPTB;MD6wOVEhyrFiMD6wNVMh\|ryP	MoX5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N\|EoRjJ3NkW5O\|MyRC:jPh?=
CMK	NIXwfZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MoXNO\|IhcA>?	MUfEUXNQ	NEiwU4FKSzVyPUCuNFU{KMLzIECuNFA6KM7:TR?=	NH\wc3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1PVc{OSd-MkW2OVk4OzF:L3G+
MV4-11	MmT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NI\ZfmI4OiCq	M2HofWROW09?	NWnUe5RUUUN3ME2wMlA2PSEEsTCwMlAzQCEQvF2=	MknrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N\|EoRjJ3NkW5O\|MyRC:jPh?=
AML-193	MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MlXXO\|IhcA>?	NHrETYpFVVOR	MVHJR\|UxRTBwNE[yJOKyKDBwME[wJO69VQ>?	NH\xcm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1PVc{OSd-MkW2OVk4OzF:L3G+
HL-60	Ml[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MkjFO\|IhcA>?	MWTEUXNQ	MWnJR\|UxRTBwMECxJOKyKDBwMECwNkDPxE1?	NGO2[I09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1PVc{OSd-MkW2OVk4OzF:L3G+
ML-2	M1;rTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MWW3NkBp	Mn3iSG1UVw>?	MlfCTWM2OD1yLkCwPUDDuSByLkCwNkDPxE1?	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N\|E9N2F-
OCI/AML3	NWLVRmJjT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		MUi3NkBp	M3jaWGROW09?	M1rz[WlEPTB;MD6wNVEhyrFiMD6wNFIh\|ryP	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N\|E9N2F-
HEL	NWXGRoNXT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NV:2XGNGPzJiaB?=	M2\3c2ROW09?	MXjJR\|UxRTBwNUW5JOKyKDBwMEO4JO69VQ>?	MnvjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N\|EoRjJ3NkW5O\|MyRC:jPh?=
ME-1	NEjXUVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MYi3NkBp	NUjENXhWTE2VTx?=	MV3JR\|UxRTBwNki0JOKyKDBwMUe5JO69VQ>?	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N\|E9N2F-
THP-1	MV;BdI9xfG:\|aYOgRZN{[Xl?	MXKxxsDPxE1?	M37hd\|czKGh?	M{HlOWROW09?	MlPUbY5lfWOnczDhdI9xfG:\|aYO=	Mn7pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N\|EoRjJ3NkW5O\|MyRC:jPh?=
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HL-60	NFXG[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		M3P1OlczyqCq	MXrEUXNQ	NEK5fFNKSzVyPUCuN{BvVQ>?	Mk\XQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4MUi4OlIoRjJ\|NkG4PFYzRC:jPh?=
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HL-60	MWDGeY5kfGmxbjDBd5NigQ>?	NXjXe2RHOcLizszN	MoXoOk8yOi9{NDDo	MYTEUXNQ	MlzkbY5pcWKrdIOgeIhmKGW6cILld5Nqd25ib3[gd5Vzfmm4aX6=	NEiwT\|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xPFg3Oid-MkO2NVg5PjJ:L3G+
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HL-60	NX;mU2xQSXCxcITvd4l{KEG\|c3H5	NGLkUpUxNjFxMTFOwG0>	NFHzTXQ5KGh?	M3XDWWROW09?	NY\E[mJqcW6mdXPld{BieG:ydH;zbZM>	NFnFRo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[xPFg3Oid-MkO2NVg5PjJ:L3G+
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BxPC-3	NGC2TnFHfW6ldHnvckBCe3OjeR?=	MlTVNE0yODByIH7N	M3HpRlI1KGh?		MkHIbY5lfWOnczDkc5dvemWpdXzheIlwdiCxZjDYTWFRKGGwZDDzeZJ3cX[rbjDlfJBz\XO\|aX;u	NFnL[\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyN\|g4OSd-MkK3NlM5PzF:L3G+
RPMI-7951	NXLTfXhyT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M3fIcGdKPTB;Mz6yJI5O	NInyT209[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUezO\|UxOid-MkG3N\|c2ODJ:L3G+
SK-MEL-5	NIO1UJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=				M{PNdWdKPTB;ND6yJI5O	M{XNOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{O3OVAzLz5{MUezO\|UxOjxxYU6=
A375	NWfhXlVQT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MWDHTVUxRTZwMzDuUS=>	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd\|N{WwNkc,OjF5M{e1NFI9N2F-
SK-MEL-28	M4TjeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7				MW\HTVUxRTdwNjDuUS=>	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd\|N{WwNkc,OjF5M{e1NFI9N2F-
SK-MEL-2	MnvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NW\4fZNrT0l3ME2xNUBvVQ>?	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd\|N{WwNkc,OjF5M{e1NFI9N2F-
DB	M3rSSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M2foZlQ5yqCq		NFfHb4FIUTVyPUOuOUBvVQ>?	M1r4cFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkO3OVA5Lz5{MUKzO\|UxQDxxYU6=
Pfeiffer	MkfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		M4O4PVQ5yqCq		M3n5cWdKPTB;Mz65JI5O	M1qzUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkO3OVA5Lz5{MUKzO\|UxQDxxYU6=
SU-DHL-5	M1P0PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		M{TvUVQ5yqCq		NVrRcJc2T0l3ME2wMlI{KG6P	NHjZPZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUKzO\|UxQCd-MkGyN\|c2ODh:L3G+
SU-DHL-8	MnTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		NH7uXm41QMLiaB?=		NVPMb\|JoT0l3ME2xMlQhdk1?	MmLsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{M{e1NFgoRjJzMkO3OVA5RC:jPh?=
WSU-DLCL-2	MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M{HJNVQ5yqCq		Mly3S2k2OD1zLkSgcm0>	NHrRNYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUKzO\|UxQCd-MkGyN\|c2ODh:L3G+
A549	MWLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?				MUjHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBOVQ6KGOnbHzzMEBKSzVyPUCuNFE{PM7:TR?=	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDhzNEO3OEc,Ojh6MUSzO\|Q9N2F-
DU145	MYfDfZRwfG:6aXPpeJkh[XO\|YYm=				NH7iSWNEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFXTF2NTDj[YxteyCkeTDNWHQh[XO\|YYmsJGVEPTB;MD6wNVM5\|ryP	MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd5NESyOkc,Ojh5N{S0NlY9N2F-
PC3	NXjVclBvS3m2b4TvfIlkcXS7IHHzd4F6				NVvNRY9[S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWEN\|IHPlcIx{KGK7IF3UWEBie3OjeTygSWM2OD1yLkC5Nu69VQ>?	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd5NESyOkc,Ojh5N{S0NlY9N2F-
A549	M33UOmZ2dmO2aX;uJIF{e2G7				M1jpV2lvcGmkaYTpc44hd2ZiUFHLNUBqdiCqdX3hckBCPTR7IHPlcIx{NCCLQ{WwQVAvPc7:TR?=	M135ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEG0N\|c1Lz5{OEixOFM4PDxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	Survivin / XIAP / Caspase-7 / Caspase-9 / Caspase-3 / Cleaved Caspase-8 / PARP; PubMed: 26771139 Oncotarget YM155 treatment decreased survivin expression without affecting XIAP and induced cleavage of caspases. Protein expression (caspase-3, -7, -9, -8, PARP) was detected by Western Blot analysis. β-catenin / c-Myc / Cyclin D1 / CD44 ; PubMed: 26771139 Oncotarget YM155 inhibited expression of CSC molecules. SGC-7901 cells were treated with YM155 at indicated doses for 24 hours. The protein levels of genes were determined by Western Blot. p-STAT3 / STAT3 ; PubMed: 22723871 PLoS One Levels of phosphorylated STAT3 and expression of survivin were analyzed by Western blotting after a 24-hours treatment with YM155 and 48 hours after transfection of 40 nM siRNA.	26771139 22723871
Immunofluorescence	EGFR; PubMed: 22723871 PLoS One YM155 (10 nM) induced the nuclear EGFR accumulation. PANC-1 cells were stained with anti-EGFR, anti-Alexa Fluor 488, and DAPI after the YM155 treatment. Scale bars: 10 µm. PARP-1 / PAR ; PubMed: 26090615 Oncotarget A. Nuclear accumulation of active PARP-1 in KYSE410 cells after 12 h of YM155 treatment was evaluated using immunofluorescent analysis. Nuclei were stained with DAPI, as shown in blue. Scale bars: 10 μm. C. Accumulation of the poly-ADP polymer in KYSE410 was evaluated using immunofluorescent analysis after YM155 treatment for 12 h. Nuclei were stained with DAPI, as shown in blue. Scale bars: 10 μm.	22723871 26090615
Growth inhibition assay	Cell viability; PubMed: 29636860 Am J Transl Res Cells were grown in 96-well plates for 24 h and treated with the indicated concentrations of YM155 or docetaxel for 72 h, and cell survival was determined by MTT assay.	29636860

体内研究

YM155按3和10 mg/kg皮下注射前列腺移植瘤，结果显示YM155完全抑制PC-3的肿瘤生长，但是重量没有降低，血细胞数也没有下降。药物动力学分析显示YM155作用于肿瘤组织效果很明显。而且，YM155按5 mg/kg作用于PC-3常位移植瘤时肿瘤抑制率达80% 。^[1]YM155和γ-射线联用作用于携带H460或Calu6 移植瘤的裸鼠，显示出强抗癌活性。^[2]

激酶实验： ^[1]	- 合并启动子-荧光酶素报告实验: 使用Pyrobest聚合酶和引物5’-GCGCGCTCGAGTCTAGACATGCGGATATATTC-3’和5’-GCGCGAA-GCTTTGGCGGTTAATGGCGCGC-3’，从人类基因组DNA中分离2767个碱基对序列的人类survivin基因启动子。在pGL3-Basic质粒的XhoI/HindIII切除位点，内切酶XhoI/HindIII切除产生的PCR片段。产生的质粒称为pSUR-luc。通过DNA测序仪在所有增强序列处测定DNA序列。通过荧光酶素实验，使用短暂转染的HeLa-S3细胞，测定pSUR-luc的活力。使用的pGL3质粒含有SV40启动子和增强子序列。 pSUR-luc和pSV2bsr 质粒通过Lipofectamin2000稳定转染到HeLa细胞中。加入10 μg/mL灭瘟素，根据适当的荧光酶素信号和基因稳定性，筛选HeLa-SURP-luc单一群落。pGL3和pSV2bsr质粒稳定转染到CHO细胞中。加入10 μg/mL灭瘟素，根据适当的荧光酶素信号和基因稳定性，筛选CHO-SV40-luc单一群落。从HeLa-SURP-luc和CHO-SV40-luc群落中获得细胞用于化学筛选。细胞按每孔5×10³接种在96孔板上，加入YM155（溶于DMSO中）。24小时后测定荧光酶素活性。通过回归分析计算IC50值。
细胞实验： ^[1]	- 合并 Cell lines: PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5，和A375细胞 Concentrations: ~ 100 nM Incubation Time: 48小时 Method: PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5，及A375细胞系按5到40×10³密度接种在96孔板上。YM155溶解在DMSO中，持续处理细胞48小时。通过sulforhodamine B试剂测定细胞数。 (Only for Reference)
动物实验： ^[1]	- 合并 Animal Models: 皮下注射PC-3移植瘤的雄性裸鼠(BALB/c nu/nu) Dosages: 5 mg/kg Administration: 皮下注射，每周持续处理3天，处理3周。 (Only for Reference)

参考文献

溶解度 (25°C)

体外	Water	89 mg/mL (200.77 mM)
	DMSO	55 mg/mL (124.07 mM)
	Ethanol	6 mg/mL (13.53 mM)
体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： Saline	30 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据 Download YM155 (Sepantronium Bromide) SDF

分子量	443.29
化学式	C₂₀H₁₉BrN₄O₃
CAS号	781661-94-7
储存条件	3年-20°C 粉状 2年-80°C 溶于溶剂
别名	N/A

动物体内配方计算器 (澄清溶液)

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO+ % + % Tween 80+ % ddH₂O

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系，公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

质量

浓度

体积

分子量
=

×

×

*在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。

稀释计算器

用本工具协助配置特定浓度的溶液，使用的计算公式为：

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入输出 )

C1

V1

C2

V2
×

=

×

在配置溶液时，请务必参考Selleck产品标签上、SDS / COA（可在Selleck的产品页面获得）批次特异的分子量使用本工具。.

连续稀释计算器方程

连续稀释
初始浓度:
稀释倍数:

计算结果

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

分子量计算器

通过输入化合物的化学式来计算其分子量：

注：化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×
计算

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01023386	Completed	Drug: YM155	Cancer	Astellas Pharma Inc	November 2009	Phase 1

技术支持

在订购、运输、储存和使用我们的产品的任何阶段，您遇到的任何问题，均可以通过拨打我们的热线电话400-668-6834，或者技术支持邮箱tech@selleck.cn，直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题，请给我们留言。

研究领域

产品类型

定制您的化合物库

YM155 (Sepantronium Bromide)

客户使用Selleck生产的YM155 (Sepantronium Bromide)发表文献151篇：

产品安全说明书

Survivin抑制剂选择性比较

生物活性

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

参考文献

溶解度 (25°C)

化学数据 Download YM155 (Sepantronium Bromide) SDF

动物体内配方计算器 (澄清溶液)

计算器

摩尔浓度计算器

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

稀释计算器

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

连续稀释计算器方程

连续稀释

计算结果

分子量计算器

总分子量：g/mol

摩尔浓度计算器

临床试验信息 (data from https://clinicaltrials.gov, updated on 2022-01-17)

技术支持

Survivin Signaling Pathway Map

相关Survivin产品