YM155 (Sepantronium Bromide)

For research use only. Not for use in humans.

目录号:S1130

YM155 (Sepantronium Bromide) Chemical Structure

CAS No. 781661-94-7

YM155 (Sepantronium Bromide)是一种有效的survivin抑制药,通过抑制Survivin启动子活性而发挥作用,在HeLa-SURP-luc 和 CHO-SV40-luc细胞中IC50为0.54 nM;对SV40启动子活性抑制作用不显著,能够轻微抑制Survivin与XIAP相互作用。YM155 在乳腺癌细胞中可下调 survivinXIAP、调节自噬并诱导自噬依赖的DNA损伤。Phase 2。

规格 价格 库存 购买数量  
10mM (1mL in DMSO) RMB 918.45 现货
RMB 568.29 现货
RMB 2214.29 现货
RMB 6310.26 现货
RMB 10401.3 现货
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客户使用Selleck生产的YM155 (Sepantronium Bromide)发表文献139篇:

产品安全说明书

Survivin抑制剂选择性比较

生物活性

产品描述 YM155 (Sepantronium Bromide)是一种有效的survivin抑制药,通过抑制Survivin启动子活性而发挥作用,在HeLa-SURP-luc 和 CHO-SV40-luc细胞中IC50为0.54 nM;对SV40启动子活性抑制作用不显著,能够轻微抑制Survivin与XIAP相互作用。YM155 在乳腺癌细胞中可下调 survivinXIAP、调节自噬并诱导自噬依赖的DNA损伤。Phase 2。
靶点
Survivin [1]
(HeLa-SURP-luc, CHO-SV40-luc cells)
0.54 nM
体外研究

YM155 30 μM时对SV40作用效果也不大。在p53缺陷的PC-3和PPC-1 人类HRPC细胞中,通过抑制 survivin基因启动子的转录,YM155显著抑制内源性survivin的表达。相反,YM155 100 nM时对c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, α-actin,及β-tubulin的蛋白表达仍没抑制效果。YM155作用于人类癌细胞系包括PC-3和PPC-1,使细胞发生凋亡,伴随着caspase-3活性上升。YM155有效抑制人类癌细胞系(突变p53或短小p53) 包括PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5及A375 ,IC50值为2.3到11 nM。[1]另外,YM155增强NSCLC细胞对γ-射线的敏感性。YM155和γ-射线联用,增强凋亡细胞数和caspase-3活性。 YM155推迟修复放射诱导核DNA断裂的双链。[2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Kasumi-1 NWDQWoVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHiVVFnPzJiaB?= MnHxSG1UVw>? MnnuTWM2OD1yLkCwPUDDuSByLkCwNFkh|ryP NVTQXHdDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVk4OzFpPkK1OlU6PzNzPD;hQi=>
M-07e MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvPO|IhcA>? NGPmT5BFVVOR NEn1SFVKSzVyPUCuNFQxKMLzIECuNFE{KM7:TR?= M3zQNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O|MyLz5{NU[1PVc{OTxxYU6=
THP-1 NW\lb4NFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVy3NkBp MUDEUXNQ NUnrS2hYUUN3ME2wMlA2OSEEsTCwMlAyOyEQvF2= MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N|E9N2F-
CMK M2rzRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorjO|IhcA>? MXvEUXNQ NXjER4ViUUN3ME2wMlA2OyEEsTCwMlAxQSEQvF2= MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N|E9N2F-
MV4-11 M2LWd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPHO|IhcA>? NXX6XG9UTE2VTx?= MW\JR|UxRTBwMEW1JOKyKDBwMEK4JO69VQ>? NX;YWXN6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVk4OzFpPkK1OlU6PzNzPD;hQi=>
AML-193 Mm\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvoO|IhcA>? Ml64SG1UVw>? NHXrW2dKSzVyPUCuOFYzKMLzIECuNFYxKM7:TR?= NITYSoY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1PVc{OSd-MkW2OVk4OzF:L3G+
HL-60 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTHO|IhcA>? MlLnSG1UVw>? MYjJR|UxRTBwMECxJOKyKDBwMECwNkDPxE1? NVmzbVRrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVk4OzFpPkK1OlU6PzNzPD;hQi=>
ML-2 MmXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnO2O|IhcA>? MoSySG1UVw>? NIL4eXdKSzVyPUCuNFA6KMLzIECuNFAzKM7:TR?= MmjnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N|EoRjJ3NkW5O|MyRC:jPh?=
OCI/AML3 NYnUU|VPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTFO|IhcA>? MYTEUXNQ MnjDTWM2OD1yLkCxNUDDuSByLkCwNkDPxE1? M3\HeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O|MyLz5{NU[1PVc{OTxxYU6=
HEL MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrPUog4OiCq M3jhXmROW09? MnPnTWM2OD1yLkW1PUDDuSByLkCzPEDPxE1? NWDxVIF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVk4OzFpPkK1OlU6PzNzPD;hQi=>
ME-1 M4XnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWW3NkBp MYLEUXNQ MUHJR|UxRTBwNki0JOKyKDBwMUe5JO69VQ>? MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N|E9N2F-
THP-1 MkPwRZBweHSxc3nzJGF{e2G7 NULPNI9iOcLizszN M4rX[lczKGh? M3fuXWROW09? M4PZSYlv\HWlZYOgZZBweHSxc3nz NWPpOYFURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVk4OzFpPkK1OlU6PzNzPD;hQi=>
M-07e MVnGeY5kfGmxbjDBd5NigQ>? NUGwNVFvOOLCk{JCpO69VQ>? MmHoO|IhcA>? NV\JNYI1TE2VTx?= NIfFbYpqdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJHN2en[rdnnu MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N|E9N2F-
THP-1 NVy1XXE6TnWwY4Tpc44hSXO|YYm= MVyw5qCUOcLizszN NIfMVFU4OiCq Mnz5SG1UVw>? MX3pcoR2[2W|IHTve45z\We3bHH0bY9vKG:oIGP1dpZqfmmw MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N|E9N2F-
CMK MXTGeY5kfGmxbjDBd5NigQ>? NWDLcVA6OOLCk{JCpO69VQ>? NUe3[Fl[PzJiaB?= Mnq0SG1UVw>? NFfQOWVqdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJHN2en[rdnnu M2i4WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O|MyLz5{NU[1PVc{OTxxYU6=
AML-193 M2r1bWZ2dmO2aX;uJGF{e2G7 NFrxNHYx6oDVMdMg{txO MUi3NkBp MoPlSG1UVw>? M1i0XIlv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gV5Vzfmm4aX6= NI\LVGs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1PVc{OSd-MkW2OVk4OzF:L3G+
Kasumi-1 NWe2blV6TnWwY4Tpc44hSXO|YYm= M1yzO|DjiJNzwrFOwG0> NUTySWJDPzJiaB?= M3LpO2ROW09? NW\MZZN4cW6mdXPld{Bld3ewcnXneYxifGmxbjDv[kBUfXK4aY\pci=> M2P3[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O|MyLz5{NU[1PVc{OTxxYU6=
MV4-11 NVLz[ZNITnWwY4Tpc44hSXO|YYm= NYfwNZVsOOLCk{JCpO69VQ>? MY[3NkBp M{PK[WROW09? NIX4R2ZqdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJHN2en[rdnnu Mn7nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N|EoRjJ3NkW5O|MyRC:jPh?=
MUG-Chor  MlrnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzEVnExNTVizszN NX\xb4VCOjRxNEigbC=> Mn23TWM2OD15LkC15qCKdk1iZn;yJFQ5cA>? M2HodFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkSwNVg2Lz5{NU[0NFE5PTxxYU6=
U-CH1  NIH5c5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;mVo9wOC13IN88US=> M162dFI1NzR6IHi= NHTLR4JKSzVyPUmuNFPjiImwTTDmc5IhPDiq MkTIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NECxPFUoRjJ3NkSwNVg2RC:jPh?=
KATOIII NUeyN4tuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYCxNE8zOCCwTR?= NH:xToM1QCCq NWXLbJIycW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NU\OU|RnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2N|UxPTVpPkK1OlM2ODV3PD;hQi=>
AGS  MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rK[lExNzJyIH7N MVW0PEBp M1\HWIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz MkfTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4M{WwOVUoRjJ3NkO1NFU2RC:jPh?=
SACC-83 M2DnXGZ2dmO2aX;uJGF{e2G7 NG\kXJU2KG6P MWS0PEBp MnT3[IVkemWjc3XzJI52[2ynYYKg[ZhxemW|c3nvckBw\iCKSV[tNe6y MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR6NU[zOUc,OjV2OEW2N|U9N2F-
INA-6 NVW2UmVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEC5UpIxNTVyMDDuUS=> NX3L[W13PDhiaB?= NG\vfGNqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? MoGyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{OU[5O|goRjJ3Mkm2PVc5RC:jPh?=
U-266 M1fvcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7UNE02ODBibl2= NIrKRng1QCCq MXTpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NGD1TFY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK5Olk4QCd-MkWyPVY6Pzh:L3G+
MOLP-8 NWT1U|NsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq4O|ExNTVyMDDuUS=> MmXsOFghcA>? MUHpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> M1vCXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mkm2PVc5Lz5{NUK5Olk4QDxxYU6=
HG-1 MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MViwMVUxOCCwTR?= MUm0PEBp MXXpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> NFzLfGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK5Olk4QCd-MkWyPVY6Pzh:L3G+
NCI-H929 M1G1WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPQNE02ODBibl2= M2fGTVQ5KGh? M{XwTIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz M2DhNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mkm2PVc5Lz5{NUK5Olk4QDxxYU6=
OPM-2 MnPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXewMVUxOCCwTR?= MUK0PEBp NFrEW|FqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>? NYPHOHBpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyPVY6PzhpPkK1Nlk3QTd6PD;hQi=>
L-363 NGnxfIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXzTmN3OC13MECgcm0> Mn20OFghcA>? MoLJbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NHjKU4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK5Olk4QCd-MkWyPVY6Pzh:L3G+
MOLP-2 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLXT3hiOC13MECgcm0> Mnr4OFghcA>? M1flfYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ7Nkm3PEc,OjV{OU[5O|g9N2F-
KMS-12-BM NIHlVJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHPfJZ6OC13MECgcm0> NED5dVM1QCCq NUL4U4Z5cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? NWXXb5FnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyPVY6PzhpPkK1Nlk3QTd6PD;hQi=>
SK-MM-2 M{Xxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPaXIMxNTVyMDDuUS=> NGLHd2c1QCCq NWnsdYc6cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ? M2LoVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mkm2PVc5Lz5{NUK5Olk4QDxxYU6=
U-266 MWDBdI9xfG:|aYOgRZN{[Xl? NWjOR5Q3OC13MDDuUS=> MkPwNlQhcA>? Mn;TbY5lfWOnczDhdI9xfG:|aYO= NXv5TnBPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyPVY6PzhpPkK1Nlk3QTd6PD;hQi=>
INA-6  MonxRZBweHSxc3nzJGF{e2G7 MVmwMVUxKG6P M375VVI1KGh? MkTTbY5lfWOnczDhdI9xfG:|aYO= MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ7Nkm3PEc,OjV{OU[5O|g9N2F-
MCF7 NU\BTnlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[3SnI4OiCq MXnJR|UxRTF|INMxJFYhdk1? M3\hZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkKwNlI2Lz5{NUKyNFIzPTxxYU6=
MCF7-TamR6 NILYTFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHOxTG04OiCq MUfJR|UxRThiwsGgOkBvVQ>? NVr2cY16RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNlAzOjVpPkK1NlIxOjJ3PD;hQi=>
MCF7-TamR7 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXW3NkBp MUfJR|UxRThiwsGgN{BvVQ>? M4fQclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3MkKwNlI2Lz5{NUKyNFIzPTxxYU6=
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SK-ES-1 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPtNE4yNTFyMECgcm0> MknNSWM2OD1{Lkigcm0tKGmwaHnibZR{KGOnbHyg[5Jwf3SqIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NHf5SVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm2NVc3Oyd-MkK5OlE4PjN:L3G+
RD-ES NF\xfnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXEb3MxNjFvMUCwNEBvVQ>? MlPpSWM2OD14LkKgcm0tKGmwaHnibZR{KGOnbHyg[5Jwf3SqIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ NIHO[Fg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm2NVc3Oyd-MkK5OlE4PjN:L3G+
HEK293 MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUGwMlEuOTByMDDuUS=> MXzFR|UxRTJ|LkCgcm0tKGmwaHnibZR{KGOnbHyg[5Jwf3SqIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl4MUe2N{c,OjJ7NkG3OlM9N2F-
M059J NHf1XohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY[wMVUxKG6P NFra[5E1QCCq MlrzbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NFS2O|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke3NFEyOCd-MkK3O|AyOTB:L3G+
M059K MlXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVSwMVUxKG6P NFjYUHk1QCCq Ml3pbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NIi4NpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke3NFEyOCd-MkK3O|AyOTB:L3G+
M059J M1e3OGFxd3C2b4Ppd{BCe3OjeR?= M2LNU|MxKG6P MkDONlQhcA>? MmjYbY5lfWOnczDhdI9xfG:|aYO= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd5MEGxNEc,OjJ5N{CxNVA9N2F-
M059K MXfBdI9xfG:|aYOgRZN{[Xl? Ml7oN|Ahdk1? NWLRPHV5OjRiaB?= MkfvbY5lfWOnczDhdI9xfG:|aYO= NIT6bmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke3NFEyOCd-MkK3O|AyOTB:L3G+
PANC-1 MnjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlriNE4xOS1zMECwJI5O NVnEPIV6PDhiaB?= NVjFXFdvUUN3ME2zMlY6KG6P NH;kS3g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyN|g4OSd-MkK3NlM5PzF:L3G+
MIAPaCa-2 M4rXbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1[wNVAvODFvMUCwNEBvVQ>? Mn7aOFghcA>? NIHxW|dKSzVyPUK5MlM3KG6P M3jkb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{KzPFcyLz5{MkeyN|g4OTxxYU6=
BxPC-3 M4HkNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnnc3oxNjBzLUGwNFAhdk1? MYq0PEBp NVvFWJZbUUN3ME2zNE4zPiCwTR?= M{XnWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{KzPFcyLz5{MkeyN|g4OTxxYU6=
PANC-1 M2nobGZ2dmO2aX;uJGF{e2G7 MYGwMVExODBibl2= MX6yOEBp MU\pcoR2[2W|IHTve45z\We3bHH0bY9vKG:oIGjJRXAh[W6mIIP1dpZqfmmwIHX4dJJme3Orb36= NGnZcZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyN|g4OSd-MkK3NlM5PzF:L3G+
MIAPaCa-2 MULGeY5kfGmxbjDBd5NigQ>? MoS3NE0yODByIH7N NFHNOG0zPCCq M4qzRolv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gXGlCWCCjbnSgd5Vzfmm4aX6g[ZhxemW|c3nvci=> M3fJdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{KzPFcyLz5{MkeyN|g4OTxxYU6=
BxPC-3 NYLRSHNVTnWwY4Tpc44hSXO|YYm= NFT0SpoxNTFyMECgcm0> MVSyOEBp NVfEWlZ4cW6mdXPld{Bld3ewcnXneYxifGmxbjDv[kBZUUGSIHHu[EB{fXK4aY\pckBmgHC{ZYPzbY9v MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{M{i3NUc,OjJ5MkO4O|E9N2F-
RPMI-7951 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fUV2dKPTB;Mz6yJI5O M1zvcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{O3OVAzLz5{MUezO|UxOjxxYU6=
SK-MEL-5 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;2[YtVT0l3ME20MlIhdk1? M336fFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{O3OVAzLz5{MUezO|UxOjxxYU6=
A375 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFP0N|FIUTVyPU[uN{BvVQ>? M2TQUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{O3OVAzLz5{MUezO|UxOjxxYU6=
SK-MEL-28 NUPSeIV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;vRWdKPTB;Nz62JI5O M3TFZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{O3OVAzLz5{MUezO|UxOjxxYU6=
SK-MEL-2 NUX6XotQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI[0c|ZIUTVyPUGxJI5O M1L6dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{O3OVAzLz5{MUezO|UxOjxxYU6=
DB MmTBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVm0POKhcA>? MnHOS2k2OD1|LkWgcm0> NIHWeFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUKzO|UxQCd-MkGyN|c2ODh:L3G+
Pfeiffer NGfpendIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfiNIE1QMLiaB?= MmH0S2k2OD1|Lkmgcm0> NWHJZ3RyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyN|c2ODhpPkKxNlM4PTB6PD;hQi=>
SU-DHL-5 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXlT|ZtPDkEoHi= NHTKS41IUTVyPUCuNlMhdk1? MlLrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF{M{e1NFgoRjJzMkO3OVA5RC:jPh?=
SU-DHL-8 NUW5SWJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W3U|Q5yqCq NYfGVolMT0l3ME2xMlQhdk1? M{[1OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkO3OVA5Lz5{MUKzO|UxQDxxYU6=
WSU-DLCL-2 NW\BfYdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHGWGM1QMLiaB?= Mn3iS2k2OD1zLkSgcm0> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ|N{WwPEc,OjF{M{e1NFg9N2F-
A549 NWfJZ2ROT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVXsVphQT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxteyxiSVO1NF0xNjBzM{VOwG0> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDhzNEO3OEc,Ojh6MUSzO|Q9N2F-
DU145 M2H4UGN6fG:2b4jpZ4l1gSCjc4PhfS=> MULDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDEWVE1PSClZXzsd{BjgSCPVGSgZZN{[XluIFXDOVA:OC5yMUO4{txO MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd5NESyOkc,Ojh5N{S0NlY9N2F-
PC3 Ml;hR5l1d3SxeHnjbZR6KGG|c3H5 NHn5RZBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[nliTWTUJIF{e2G7LDDFR|UxRTBwMEmy{txO MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd5NESyOkc,Ojh5N{S0NlY9N2F-
A549 M{S0fGZ2dmO2aX;uJIF{e2G7 NVv6[2ZqUW6qaXLpeIlwdiCxZjDQRWsyKGmwIHj1cYFvKEF3NEmgZ4VtdHNuIFnDOVA:OC53zszN NFfaOY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEixOFM4PCd-Mki4NVQ{PzR:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
Survivin / XIAP / Caspase-7 / Caspase-9 / Caspase-3 / Cleaved Caspase-8 / PARP; 

PubMed: 26771139     


YM155 treatment decreased survivin expression without affecting XIAP and induced cleavage of caspases. Protein expression (caspase-3, -7, -9, -8, PARP) was detected by Western Blot analysis. 

β-catenin / c-Myc / Cyclin D1 / CD44 ; 

PubMed: 26771139     


YM155 inhibited expression of CSC molecules. SGC-7901 cells were treated with YM155 at indicated doses for 24 hours. The protein levels of genes were determined by Western Blot.

p-STAT3 / STAT3 ; 

PubMed: 22723871     


Levels of phosphorylated STAT3 and expression of survivin were analyzed by Western blotting after a 24-hours treatment with YM155 and 48 hours after transfection of 40 nM siRNA.

26771139 22723871
Immunofluorescence
EGFR; 

PubMed: 22723871     


YM155 (10 nM) induced the nuclear EGFR accumulation. PANC-1 cells were stained with anti-EGFR, anti-Alexa Fluor 488, and DAPI after the YM155 treatment. Scale bars: 10 µm.

PARP-1 / PAR ; 

PubMed: 26090615     


A. Nuclear accumulation of active PARP-1 in KYSE410 cells after 12 h of YM155 treatment was evaluated using immunofluorescent analysis. Nuclei were stained with DAPI, as shown in blue. Scale bars: 10 μm. C. Accumulation of the poly-ADP polymer in KYSE410 was evaluated using immunofluorescent analysis after YM155 treatment for 12 h. Nuclei were stained with DAPI, as shown in blue. Scale bars: 10 μm. 

22723871 26090615
Growth inhibition assay
Cell viability; 

PubMed: 29636860     


Cells were grown in 96-well plates for 24 h and treated with the indicated concentrations of YM155 or docetaxel for 72 h, and cell survival was determined by MTT assay.

29636860
体内研究 YM155按3和10 mg/kg皮下注射前列腺移植瘤,结果显示YM155完全抑制PC-3的肿瘤生长,但是重量没有降低,血细胞数也没有下降。药物动力学分析显示YM155作用于肿瘤组织效果很明显。而且,YM155按5 mg/kg作用于PC-3常位移植瘤时肿瘤抑制率达80% 。[1]YM155和γ-射线联用作用于携带H460或Calu6 移植瘤的裸鼠,显示出强抗癌活性。[2]

推荐的实验操作(此推荐来自于公开的文献所以Selleck并不保证其有效性)

激酶实验:

[1]

- 合并

启动子-荧光酶素报告实验:

使用Pyrobest聚合酶和引物5’-GCGCGCTCGAGTCTAGACATGCGGATATATTC-3’和5’-GCGCGAA-GCTTTGGCGGTTAATGGCGCGC-3’, 从人类基因组DNA中分离2767个碱基对序列的人类survivin基因启动子。在pGL3-Basic质粒的XhoI/HindIII切除位点,内切酶XhoI/HindIII切除产生的PCR片段。产生的质粒称为pSUR-luc。通过DNA测序仪在所有增强序列处测定DNA序列。通过荧光酶素实验,使用短暂转染的HeLa-S3细胞,测定pSUR-luc的活力。使用的pGL3质粒含有SV40启动子和增强子序列。 pSUR-luc和pSV2bsr 质粒通过Lipofectamin2000稳定转染到HeLa细胞中。加入10 μg/mL灭瘟素,根据适当的荧光酶素信号和基因稳定性,筛选HeLa-SURP-luc单一群落。pGL3和pSV2bsr质粒稳定转染到CHO细胞中。加入10 μg/mL灭瘟素,根据适当的荧光酶素信号和基因稳定性,筛选CHO-SV40-luc单一群落。从HeLa-SURP-luc和CHO-SV40-luc群落中获得细胞用于化学筛选。细胞按每孔5×103接种在96孔板上,加入YM155(溶于DMSO中)。24小时后测定荧光酶素活性。通过回归分析计算IC50值。
细胞实验:

[1]

- 合并
  • Cell lines: PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5,和A375细胞
  • Concentrations: ~ 100 nM
  • Incubation Time: 48小时
  • Method:

    PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5,及A375细胞系按5到40×103密度接种在96孔板上。YM155溶解在DMSO中,持续处理细胞48小时。通过sulforhodamine B试剂测定细胞数。


    (Only for Reference)
动物实验:

[1]

- 合并
  • Animal Models: 皮下注射PC-3移植瘤的雄性裸鼠(BALB/c nu/nu)
  • Dosages: 5 mg/kg
  • Administration: 皮下注射,每周持续处理3天,处理3周。
    (Only for Reference)

溶解度 (25°C)

体外 Water 89 mg/mL (200.77 mM)
DMSO 55 mg/mL (124.07 mM)
Ethanol 6 mg/mL (13.53 mM)
体内 从左到右依次将纯溶剂加入产品,现配现用(数据来自Selleck实验检测而非文献):
Saline
30 mg/mL

* 溶解度检测是由Selleck技术部门检测的,可能会和文献中提供的溶解度有所差异,这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量 443.29
化学式

C20H19BrN4O3

CAS号 781661-94-7
储存条件 粉状
溶于溶剂
别名 N/A

动物体内配方计算器 (澄清溶液)

第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 ul 动物数量
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系Selleck为您提供正确的澄清溶液配方)
% DMSO % % Tween 80 % ddH2O
计算重置

计算器

摩尔浓度计算器

摩尔浓度计算器

本计算器可帮助您计算出特定溶液中溶质的质量、溶液浓度和体积之间的关系,公式为:

质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)

摩尔浓度计算公式

  • 质量
    浓度
    体积
    分子量

*在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。

稀释计算器

稀释计算器

用本工具协助配置特定浓度的溶液,使用的计算公式为:

开始浓度 x 开始体积 = 最终浓度 x 最终体积

稀释公式

稀释公式一般简略地表示为: C1V1 = C2V2 ( 输入 输出 )

  • C1
    V1
    C2
    V2

在配置溶液时,请务必参考Selleck产品标签上、MSDS / COA(可在Selleck的产品页面获得)批次特异的分子量使用本工具。.

连续稀释计算器方程

  • 连续稀释

  • 计算结果

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
分子量计算器

分子量计算器

通过输入化合物的化学式来计算其分子量:

总分子量:g/mol

注:化学分子式大小写敏感。C10H16N2O2 c10h16n2o2

摩尔浓度计算器

质量 浓度 体积 分子量
计算

临床试验信息

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01023386 Completed Drug: YM155 Cancer Astellas Pharma Inc November 2009 Phase 1

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在订购、运输、储存和使用我们的产品的任何阶段,您遇到的任何问题,均可以通过拨打我们的热线电话400-668-6834,或者技术支持邮箱tech@selleck.cn,直接联系到我们。我们会在24小时内尽快联系您。

操作手册

如果有其他问题,请给我们留言。

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Survivin Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID