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YM155 (Sepantronium Bromide)

目录号：S1130

仅限科研使用

YM155 (Sepantronium Bromide)是一种有效的survivin抑制药，通过抑制Survivin启动子活性而发挥作用，在HeLa-SURP-luc 和 CHO-SV40-luc细胞中IC50为0.54 nM；对SV40启动子活性抑制作用不显著，能够轻微抑制Survivin与XIAP相互作用。YM155 在乳腺癌细胞中可下调 survivin 和 XIAP、调节自噬并诱导自噬依赖的DNA损伤。Phase 2。

YM155 (Sepantronium Bromide) Chemical Structure

CAS: 781661-94-7

规格	价格	库存
10mM (1mL in DMSO)	RMB 918.45	现货
5mg	RMB 568.29	现货
25mg	RMB 2214.29	现货
100mg	RMB 6310.26	现货
大包装	有超大折扣
大剂量询单有大折扣!
今日订购，明日送达全国免运费分装免费分装成小规格产品（单支最小为1mg）如1支10mg产品可分装为10支1mg产品全国免费电话：400-668-6834 \| Email：info@selleck.cn

客户使用Selleck生产的YM155 (Sepantronium Bromide)发表文献158篇：

产品安全说明书

Survivin抑制剂选择性比较

生物活性

产品描述

靶点

Survivin ^[1]
(HeLa-SURP-luc, CHO-SV40-luc cells)

0.54 nM

体外研究

YM155 30 μM时对SV40作用效果也不大。在p53缺陷的PC-3和PPC-1 人类HRPC细胞中，通过抑制 survivin基因启动子的转录，YM155显著抑制内源性survivin的表达。相反，YM155 100 nM时对c-IAP2, XIAP, Bcl-2, Bcl-xL, Bad, α-actin,及β-tubulin的蛋白表达仍没抑制效果。YM155作用于人类癌细胞系包括PC-3和PPC-1，使细胞发生凋亡，伴随着caspase-3活性上升。YM155有效抑制人类癌细胞系(突变p53或短小p53) 包括PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5及A375 ，IC50值为2.3到11 nM。^[1]另外，YM155增强NSCLC细胞对γ-射线的敏感性。YM155和γ-射线联用，增强凋亡细胞数和caspase-3活性。 YM155推迟修复放射诱导核DNA断裂的双链。^[2]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Kasumi-1	M36yV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MlLCO\|IhcA>?	NIPSPIVFVVOR	M2LvXWlEPTB;MD6wNFkhyrFiMD6wNFA6KM7:TR?=	MorxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N\|EoRjJ3NkW5O\|MyRC:jPh?=
M-07e	NWDEd5hoT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NX64RXdTPzJiaB?=	M3PkZmROW09?	MXLJR\|UxRTBwMESwJOKyKDBwMEGzJO69VQ>?	NEHEfo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[1PVc{OSd-MkW2OVk4OzF:L3G+
THP-1	NGjnT29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MVS3NkBp	Ml\0SG1UVw>?	NFX2eoRKSzVyPUCuNFUyKMLzIECuNFE{KM7:TR?=	NXq1b2lMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVk4OzFpPkK1OlU6PzNzPD;hQi=>
CMK	NV7YS5ZuT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		NInVOlI4OiCq	NVeyUJB7TE2VTx?=	NWi0[oFYUUN3ME2wMlA2OyEEsTCwMlAxQSEQvF2=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N\|E9N2F-
MV4-11	MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M3nHUVczKGh?	Ml6ySG1UVw>?	NX;mWW5tUUN3ME2wMlA2PSEEsTCwMlAzQCEQvF2=	NVHBbHJ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVk4OzFpPkK1OlU6PzNzPD;hQi=>
AML-193	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NHG2WpY4OiCq	M1XGbGROW09?	NIfTR5lKSzVyPUCuOFYzKMLzIECuNFYxKM7:TR?=	NUX2XmZ[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVk4OzFpPkK1OlU6PzNzPD;hQi=>
HL-60	NV2yUYt7T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=		M1m1eVczKGh?	M1rWe2ROW09?	NVfLb5N3UUN3ME2wMlAxOSEEsTCwMlAxODJizszN	MmTOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N\|EoRjJ3NkW5O\|MyRC:jPh?=
ML-2	MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		NUPWRoE6PzJiaB?=	MXPEUXNQ	NVzSW2JHUUN3ME2wMlAxQSEEsTCwMlAxOiEQvF2=	M3zBW\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O\|MyLz5{NU[1PVc{OTxxYU6=
OCI/AML3	NH2zbFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NFzGUng4OiCq	NV3GeZp6TE2VTx?=	NUXyU5FtUUN3ME2wMlAyOSEEsTCwMlAxOiEQvF2=	NY\zRmNnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OVk4OzFpPkK1OlU6PzNzPD;hQi=>
HEL	Mnu4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MmnhO\|IhcA>?	M{fhbmROW09?	M4DkdmlEPTB;MD61OVkhyrFiMD6wN\|gh\|ryP	M4PDclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O\|MyLz5{NU[1PVc{OTxxYU6=
ME-1	NEO2ZWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MnXNO\|IhcA>?	NWPGbYJ6TE2VTx?=	M2mxXWlEPTB;MD62PFQhyrFiMD6xO\|kh\|ryP	M1H6WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O\|MyLz5{NU[1PVc{OTxxYU6=
THP-1	M3vtS2Fxd3C2b4Ppd{BCe3OjeR?=	MUSxxsDPxE1?	NGH1dWo4OiCq	NWK1c4JYTE2VTx?=	M2q1U4lv\HWlZYOgZZBweHSxc3nz	Mki5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N\|EoRjJ3NkW5O\|MyRC:jPh?=
M-07e	M2j4UWZ2dmO2aX;uJGF{e2G7	NITsbpox6oDVMdMg{txO	M{S0d\|czKGh?	MUXEUXNQ	NHP4e5NqdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJHN2en[rdnnu	MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N\|E9N2F-
THP-1	NXTkVIpJTnWwY4Tpc44hSXO\|YYm=	NV2xU2VJOOLCk{JCpO69VQ>?	Mof1O\|IhcA>?	NXXZZ2wxTE2VTx?=	M{LGRolv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gV5Vzfmm4aX6=	MkLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N\|EoRjJ3NkW5O\|MyRC:jPh?=
CMK	NWDtZZlQTnWwY4Tpc44hSXO\|YYm=	M1vVZlDjiJNzwrFOwG0>	NGqxTVE4OiCq	Ml:wSG1UVw>?	NHfnb\|NqdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJHN2en[rdnnu	M3;YdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O\|MyLz5{NU[1PVc{OTxxYU6=
AML-193	MXjGeY5kfGmxbjDBd5NigQ>?	MYqw5qCUOcLizszN	NITRfIQ4OiCq	MVPEUXNQ	M1XM[olv\HWlZYOg[I94dnKnZ4XsZZRqd25ib3[gV5Vzfmm4aX6=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ3OUezNUc,OjV4NUm3N\|E9N2F-
Kasumi-1	NHPPVndHfW6ldHnvckBCe3OjeR?=	M3;vSlDjiJNzwrFOwG0>	NIixOnY4OiCq	NUfYZ3luTE2VTx?=	NWDUSm5DcW6mdXPld{Bld3ewcnXneYxifGmxbjDv[kBUfXK4aY\pci=>	Mn\iQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NUm3N\|EoRjJ3NkW5O\|MyRC:jPh?=
MV4-11	NHK3WmdHfW6ldHnvckBCe3OjeR?=	Ml3TNQKBmzIEoN88US=>	Moi1O\|IhcA>?	MVjEUXNQ	MoS5bY5lfWOnczDkc5dvemWpdXzheIlwdiCxZjDTeZJ3cX[rbh?=	M2XGNVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkW5O\|MyLz5{NU[1PVc{OTxxYU6=
MUG-Chor	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MXmwMVUh\|ryP	MVOyOE81QCCq		NVTDPWhbUUN3ME23MlA26oDLbl2g[o9zKDR6aB?=	NFvselQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[0NFE5PSd-MkW2OFAyQDV:L3G+
U-CH1	MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MlLJNE02KM7:TR?=	NFrmU2MzPC92ODDo		MXXJR\|UxRTlwMERihKlvVSCob4KgOFhp	NVjDcG5YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2OFAyQDVpPkK1OlQxOTh3PD;hQi=>
KATOIII	NWnzNXh{T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlLsNVAwOjBibl2=	NVfaXFhCPDhiaB?=		NGrleolqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>?	NES3W3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[zOVA2PSd-MkW2N\|UxPTV:L3G+
AGS	M1vPbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M1fSTlExNzJyIH7N	MofGOFghcA>?		NHHaZ\|JqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>?	NUm5e2JbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2N\|UxPTVpPkK1OlM2ODV3PD;hQi=>
SACC-83	MmHNSpVv[3Srb36gRZN{[Xl?	NHrvbok2KG6P	M3fyV\|Q5KGh?		Mn3w[IVkemWjc3XzJI52[2ynYYKg[ZhxemW\|c3nvckBw\iCKSV[tNe6y	MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTR6NU[zOUc,OjV2OEW2N\|U9N2F-
INA-6	NH;lc5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NF;GW\|MxNTVyMDDuUS=>	MnrZOFghcA>?		M3yxfYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz	M4L6fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mkm2PVc5Lz5{NUK5Olk4QDxxYU6=
U-266	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MViwMVUxOCCwTR?=	MnvKOFghcA>?		MVrpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=>	MkLaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{OU[5O\|goRjJ3Mkm2PVc5RC:jPh?=
MOLP-8	M1zWWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NFvD[GUxNTVyMDDuUS=>	NVq1c2drPDhiaB?=		M3zMdYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz	M2\CRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mkm2PVc5Lz5{NUK5Olk4QDxxYU6=
HG-1	MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4fMSlAuPTByIH7N	M1\WPVQ5KGh?		NWfFVJhocW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ?	NGDGcWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK5Olk4QCd-MkWyPVY6Pzh:L3G+
NCI-H929	NUP0Z3k1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NI\4bIgxNTVyMDDuUS=>	MYq0PEBp		NEf1Z3dqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>?	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ7Nkm3PEc,OjV{OU[5O\|g9N2F-
OPM-2	NIfoTZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NVfHdYRTOC13MECgcm0>	NFrjcok1QCCq		M1f3eYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz	M2ryflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mkm2PVc5Lz5{NUK5Olk4QDxxYU6=
L-363	NETEcYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUOwMVUxOCCwTR?=	Mlz6OFghcA>?		NITPdG1qdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meg>?	M4jLcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mkm2PVc5Lz5{NUK5Olk4QDxxYU6=
MOLP-2	NUTHXY5pT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MlKxNE02ODBibl2=	NUPJWoNXPDhiaB?=		NYLsPZVPcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ?	M1jXb\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Mkm2PVc5Lz5{NUK5Olk4QDxxYU6=
KMS-12-BM	MkDnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M3nlZlAuPTByIH7N	MUm0PEBp		MUnpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=>	NXzOdVA1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyPVY6PzhpPkK1Nlk3QTd6PD;hQi=>
SK-MM-2	NIe0eoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MUmwMVUxOCCwTR?=	NYLBOlRtPDhiaB?=		NUjxOIxGcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ?	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ7Nkm3PEc,OjV{OU[5O\|g9N2F-
U-266	MWLBdI9xfG:\|aYOgRZN{[Xl?	Mn;ENE02OCCwTR?=	Mm[yNlQhcA>?		MWXpcoR2[2W\|IHHwc5B1d3Orcx?=	MnnEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{OU[5O\|goRjJ3Mkm2PVc5RC:jPh?=
INA-6	M2jIZ2Fxd3C2b4Ppd{BCe3OjeR?=	MlfGNE02OCCwTR?=	MVSyOEBp		MnvZbY5lfWOnczDhdI9xfG:\|aYO=	NHrZNVg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUK5Olk4QCd-MkWyPVY6Pzh:L3G+
MCF7	MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?		MmHYO\|IhcA>?		MoD2TWM2OD1zMzFCtUA3KG6P	MoXRQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{MkCyNlUoRjJ3MkKwNlI2RC:jPh?=
MCF7-TamR6	MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MU[3NkBp		NX\DcnZkUUN3ME24JOKyKDZibl2=	NXi2OpQ6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNlAzOjVpPkK1NlIxOjJ3PD;hQi=>
MCF7-TamR7	MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		M3iyRVczKGh?		MlHjTWM2OD16INMxJFMhdk1?	NHS0ZXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKyNFIzPSd-MkWyNlAzOjV:L3G+
MCF7-TamR8	MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?		MV[3NkBp		MX7JR\|UxRTF3INMxJFYhdk1?	Mn3pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV{MkCyNlUoRjJ3MkKwNlI2RC:jPh?=
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SK-ES-1	MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M4\JS\|AvOS1zMECwJI5O			M4PmOWVEPTB;Mj64JI5ONCCrbnjpZol1eyClZXzsJIdzd3e2aDDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl4MUe2N{c,OjJ7NkG3OlM9N2F-
RD-ES	NEnycopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MoTXNE4yNTFyMECgcm0>			MUfFR\|UxRTZwMjDuUUwhcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ?	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl4MUe2N{c,OjJ7NkG3OlM9N2F-
HEK293	MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MV2wMlEuOTByMDDuUS=>			NFu3XGdGSzVyPUKzMlAhdk1uIHnubIljcXS\|IHPlcIwh\3Kxd4ToJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy	MnG0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7NkG3OlMoRjJ{OU[xO\|Y{RC:jPh?=
M059J	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	M2H3c\|AuPTBibl2=	M2Xzc\|Q5KGh?		NWXJRXZrcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\XJ?	NYLDNINRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3O\|AyOTBpPkKyO\|cxOTFyPD;hQi=>
M059K	NXn1VIFWT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M1jm[lAuPTBibl2=	MXi0PEBp		M1LhfolvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoVz	NGTNeG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mke3NFEyOCd-MkK3O\|AyOTB:L3G+
M059J	MXPBdI9xfG:\|aYOgRZN{[Xl?	MmHpN\|Ahdk1?	MWOyOEBp		NYfJR\|R5cW6mdXPld{BieG:ydH;zbZM>	MkDhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5N{CxNVAoRjJ{N{ewNVExRC:jPh?=
M059K	NViwUFJqSXCxcITvd4l{KEG\|c3H5	MXezNEBvVQ>?	MlfWNlQhcA>?		NYfFcZU4cW6mdXPld{BieG:ydH;zbZM>	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd5MEGxNEc,OjJ5N{CxNVA9N2F-
PANC-1	NFzTdJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MYmwMlAyNTFyMECgcm0>	NHPqXlM1QCCq		NFLyTFFKSzVyPUOuOlkhdk1?	NFS0bWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyN\|g4OSd-MkK3NlM5PzF:L3G+
MIAPaCa-2	NVi4c2JvT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NHfqTGoxNjBzLUGwNFAhdk1?	NGPiV3k1QCCq		M2nsUWlEPTB;MkmuN\|Yhdk1?	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{M{i3NUc,OjJ5MkO4O\|E9N2F-
BxPC-3	NGO5[VJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MornNE4xOS1zMECwJI5O	M125bFQ5KGh?		M3HoNmlEPTB;M{CuNlYhdk1?	NXTaU5o3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK3NlM5PzFpPkKyO\|I{QDdzPD;hQi=>
PANC-1	MWXGeY5kfGmxbjDBd5NigQ>?	MUKwMVExODBibl2=	MUiyOEBp		Ml\6bY5lfWOnczDkc5dvemWpdXzheIlwdiCxZjDYTWFRKGGwZDDzeZJ3cX[rbjDlfJBz\XO\|aX;u	MoPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5MkO4O\|EoRjJ{N{KzPFcyRC:jPh?=
MIAPaCa-2	M1jJTGZ2dmO2aX;uJGF{e2G7	MoK2NE0yODByIH7N	MoT0NlQhcA>?		MUHpcoR2[2W\|IHTve45z\We3bHH0bY9vKG:oIGjJRXAh[W6mIIP1dpZqfmmwIHX4dJJme3Orb36=	NGjLN2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkeyN\|g4OSd-MkK3NlM5PzF:L3G+
BxPC-3	NUK4ZlJyTnWwY4Tpc44hSXO\|YYm=	MnqyNE0yODByIH7N	MnH6NlQhcA>?		NHPNXmdqdmS3Y3XzJIRwf26{ZXf1cIF1cW:wIH;mJHhKSVBiYX7kJJN2en[rdnnuJIV5eHKnc4Ppc44>	M3yzbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{KzPFcyLz5{MkeyN\|g4OTxxYU6=
RPMI-7951	NXjsdJRsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				M1ewZWdKPTB;Mz6yJI5O	M1K0PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{O3OVAzLz5{MUezO\|UxOjxxYU6=
SK-MEL-5	MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MUfHTVUxRTRwMjDuUS=>	NFz2bYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUezO\|UxOid-MkG3N\|c2ODJ:L3G+
A375	MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				MXnHTVUxRTZwMzDuUS=>	M3OwZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{O3OVAzLz5{MUezO\|UxOjxxYU6=
SK-MEL-28	NXvicFVST3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=				MUXHTVUxRTdwNjDuUS=>	NIr3XW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUezO\|UxOid-MkG3N\|c2ODJ:L3G+
SK-MEL-2	MoGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?				NGTBcGhIUTVyPUGxJI5O	NHj4cVU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUezO\|UxOid-MkG3N\|c2ODJ:L3G+
DB	M{jXO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MV[0POKhcA>?		NVLhcmo6T0l3ME2zMlUhdk1?	NVrPOndpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyN\|c2ODhpPkKxNlM4PTB6PD;hQi=>
Pfeiffer	M4PRbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7		MVi0POKhcA>?		MknDS2k2OD1\|Lkmgcm0>	NFXXWnA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUKzO\|UxQCd-MkGyN\|c2ODh:L3G+
SU-DHL-5	NGnwfZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		MlzlOFjDqGh?		MWnHTVUxRTBwMkOgcm0>	M2DDRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzMkO3OVA5Lz5{MUKzO\|UxQDxxYU6=
SU-DHL-8	NFvtTXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NG\RUoU1QMLiaB?=		NHP0SIhIUTVyPUGuOEBvVQ>?	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTJ\|N{WwPEc,OjF{M{e1NFg9N2F-
WSU-DLCL-2	NHL3dndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=		NFjtcHM1QMLiaB?=		M1KyR2dKPTB;MT60JI5O	NUPJTW1vRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkGyN\|c2ODhpPkKxNlM4PTB6PD;hQi=>
A549	M13zbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7				MX3Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBOVQ6KGOnbHzzMEBKSzVyPUCuNFE{PM7:TR?=	MmP5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh6MUSzO\|QoRjJ6OEG0N\|c1RC:jPh?=
DU145	M{T3bmN6fG:2b4jpZ4l1gSCjc4PhfS=>				NUja[ZNJS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTFVzNEWgZ4VtdHNiYomgUXRVKGG\|c3H5MEBGSzVyPUCuNFE{QM7:TR?=	M{DD[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{e0OFI3Lz5{OEe3OFQzPjxxYU6=
PC3	MYTDfZRwfG:6aXPpeJkh[XO\|YYm=				NFzmUnFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBRSzNiY3XscJMh[nliTWTUJIF{e2G7LDDFR\|UxRTBwMEmy{txO	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd5NESyOkc,Ojh5N{S0NlY9N2F-
A549	NULiRpRKTnWwY4Tpc44h[XO\|YYm=				MVXJcohq[mm2aX;uJI9nKFCDS{GgbY4hcHWvYX6gRVU1QSClZXzsd{whUUN3ME2wMlXPxE1?	M3HPU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEG0N\|c1Lz5{OEixOFM4PDxxYU6=

Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID

Western blot	Survivin / XIAP / Caspase-7 / Caspase-9 / Caspase-3 / Cleaved Caspase-8 / PARP β-catenin / c-Myc / Cyclin D1 / CD44 p-STAT3 / STAT3	26771139 22723871
Immunofluorescence	EGFR PARP-1 / PAR	22723871 26090615
Growth inhibition assay	Cell viability	29636860

体内研究

YM155按3和10 mg/kg皮下注射前列腺移植瘤，结果显示YM155完全抑制PC-3的肿瘤生长，但是重量没有降低，血细胞数也没有下降。药物动力学分析显示YM155作用于肿瘤组织效果很明显。而且，YM155按5 mg/kg作用于PC-3常位移植瘤时肿瘤抑制率达80% 。^[1]YM155和γ-射线联用作用于携带H460或Calu6 移植瘤的裸鼠，显示出强抗癌活性。^[2]

激酶实验： ^[1]	启动子-荧光酶素报告实验: 使用Pyrobest聚合酶和引物5’-GCGCGCTCGAGTCTAGACATGCGGATATATTC-3’和5’-GCGCGAA-GCTTTGGCGGTTAATGGCGCGC-3’，从人类基因组DNA中分离2767个碱基对序列的人类survivin基因启动子。在pGL3-Basic质粒的XhoI/HindIII切除位点，内切酶XhoI/HindIII切除产生的PCR片段。产生的质粒称为pSUR-luc。通过DNA测序仪在所有增强序列处测定DNA序列。通过荧光酶素实验，使用短暂转染的HeLa-S3细胞，测定pSUR-luc的活力。使用的pGL3质粒含有SV40启动子和增强子序列。 pSUR-luc和pSV2bsr 质粒通过Lipofectamin2000稳定转染到HeLa细胞中。加入10 μg/mL灭瘟素，根据适当的荧光酶素信号和基因稳定性，筛选HeLa-SURP-luc单一群落。pGL3和pSV2bsr质粒稳定转染到CHO细胞中。加入10 μg/mL灭瘟素，根据适当的荧光酶素信号和基因稳定性，筛选CHO-SV40-luc单一群落。从HeLa-SURP-luc和CHO-SV40-luc群落中获得细胞用于化学筛选。细胞按每孔5×10³接种在96孔板上，加入YM155（溶于DMSO中）。24小时后测定荧光酶素活性。通过回归分析计算IC50值。
细胞实验： ^[1]	Cell lines: PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5，和A375细胞 Concentrations: ~ 100 nM Incubation Time: 48小时 Method: PC-3, PPC-1, DU145, TSU-Pr1, 22Rv1, SK-MEL-5，及A375细胞系按5到40×10³密度接种在96孔板上。YM155溶解在DMSO中，持续处理细胞48小时。通过sulforhodamine B试剂测定细胞数。
动物实验： ^[1]	Animal Models: 皮下注射PC-3移植瘤的雄性裸鼠(BALB/c nu/nu) Dosages: 5 mg/kg Administration: 皮下注射，每周持续处理3天，处理3周。

参考文献	[1] Nakahara T, et al. Cancer Res, 2007, 67(17), 8014-8021. [2] Iwasa T, et al. Clin Cancer Res, 2008, 14(20), 6496-6504.

溶解度（25°C）

体外


体内	从左到右依次将纯溶剂加入产品，现配现用(数据来自Selleck实验检测而非文献)： Saline	30 mg/mL

* 溶解度检测是由Selleck技术部门检测的，可能会和文献中提供的溶解度有所差异，这是由于生产工艺和批次不同产生的正常现象。请按照顺序依次加入各个纯溶剂。

化学数据

分子量	443.29
化学式	C₂₀H₁₉BrN₄O₃
CAS号	781661-94-7
储存条件	3年	-20°C	粉状
储存条件	2年	-80°C	溶于溶剂

Download YM155 (Sepantronium Bromide) SDF

动物体内配方计算器（澄清溶液）

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量 mg/kg 动物平均体重 g 每只动物给药体积 μL 动物数量只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系Selleck为您提供正确的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

计算结果：

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于μL DMSO溶液（母液浓度mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系Selleck）；

体内配方配制方法：取μL DMSO母液，加入μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入μL ddH₂O，混匀澄清。

体内配方配制方法：取μL DMSO母液，加入μL Corn oil，混匀澄清。

注意：1. 首先保证母液是澄清的；
2.一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

摩尔浓度计算器

质量	浓度	体积	分子量
=	×	×

稀释计算器分子量计算器

临床试验信息

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01023386	Completed	Drug: YM155	Cancer	Astellas Pharma Inc	November 2009	Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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