cGAS

抑制剂选择性比较

cGAS产品

目录号 产品描述 文献引用 实验数据
S6841New

RU.521

RU.521 是一种活跃的 cyclic GMP-AMP synthase (cGAS) 的有效的选择性抑制剂,可抑制cGAS介导的信号传导,其IC50值为700 nM。RU.521 与cGAS/dsDNA 复合物结合的Kd值为36.2 nM。

S9615New

PF-06928215

PF-06928215 is a high affinity active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 4.9 μM.

S0775New

IRAK4-IN-4

IRAK4-IN-4 is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) with IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with IC50 of 2.1 nM.

S8944New

G150

G150是一种有效的、高选择性的 human cyclic GMP-AMP synthase (cGAS) 抑制剂,IC50为10.2 nM。

目录号 产品描述 文献引用 实验数据
S6841New

RU.521

RU.521 是一种活跃的 cyclic GMP-AMP synthase (cGAS) 的有效的选择性抑制剂,可抑制cGAS介导的信号传导,其IC50值为700 nM。RU.521 与cGAS/dsDNA 复合物结合的Kd值为36.2 nM。

S9615New

PF-06928215

PF-06928215 is a high affinity active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 4.9 μM.

S0775New

IRAK4-IN-4

IRAK4-IN-4 is an inhibitor of interleukin-1 receptor–associated kinase 4 (IRAK4) with IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with IC50 of 2.1 nM.

S8944New

G150

G150是一种有效的、高选择性的 human cyclic GMP-AMP synthase (cGAS) 抑制剂,IC50为10.2 nM。