FTase

抑制剂选择性比较

FTase产品

所有产品(4) FTase抑制剂(4)

目录号	产品描述	文献引用	实验数据
S1453	Tipifarnib (R115777) Tipifarnib (R115777, IND 58359) 是一种有效的，特异性farnesyltransferase (FTase)抑制剂，作用于H-ras或N-ras突变细胞，具有最显著的抗增殖作用效果。Phase 3。	Cancers (Basel), 2022, 14(4)903 Front Microbiol, 2021, 12:628283 Int Immunopharmacol, 2020, 3;83:106462	Effects of tipifarnib on GalN/LPS-induced mortality and ALF in mice. Representative liver histology (H/E staining at 5 h after saline or GalN/LPS) by microscopic images are shown.
S7467	LB42708 LB42708 是一种口服有效的farnesyltransferase (FTase)抑制剂。
S0404	Tipifarnib S enantiomer Tipifarnib S enantiomer ((S)-(-)-R-115777,IND-58359 S enantiomer) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific inhibitor of farnesyltransferase (FTase) with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.
S7465	FTI 277 HCl FTI 277 HCl是FTI 277的甲酯，是一种有效的选择性farnesyltransferase (FTase)抑制剂，IC50为500 pM，选择性比密切相关的GGTase I 高100倍。FTI 277 HCl可抑制细胞生长并诱导凋亡。FTI 277 HCl可有效清除HDV病毒血症。	PLoS Biol, 2021, 19(4):e3001134 Cell Struct Funct, 2021, 46(1):1-9 Nat Commun, 2019, 10(1):273	(A) HCT 116 cells were treated with Tram (0, 30, or 60 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD. (B) SW480 and MDA-MB-231 cells were treated with Tram (0, 80, 160 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD.

目录号	产品描述	文献引用	实验数据
S1453	Tipifarnib (R115777) Tipifarnib (R115777, IND 58359) 是一种有效的，特异性farnesyltransferase (FTase)抑制剂，作用于H-ras或N-ras突变细胞，具有最显著的抗增殖作用效果。Phase 3。	Cancers (Basel),2022, 14(4)903 Front Microbiol,2021, 12:628283 Int Immunopharmacol,2020, 3;83:106462	Effects of tipifarnib on GalN/LPS-induced mortality and ALF in mice. Representative liver histology (H/E staining at 5 h after saline or GalN/LPS) by microscopic images are shown.
S7467	LB42708 LB42708 是一种口服有效的farnesyltransferase (FTase)抑制剂。
S0404	Tipifarnib S enantiomer Tipifarnib S enantiomer ((S)-(-)-R-115777,IND-58359 S enantiomer) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific inhibitor of farnesyltransferase (FTase) with IC50 of 0.6 nM. Tipifarnib S enantiomer is the less active isomer.
S7465	FTI 277 HCl FTI 277 HCl是FTI 277的甲酯，是一种有效的选择性farnesyltransferase (FTase)抑制剂，IC50为500 pM，选择性比密切相关的GGTase I 高100倍。FTI 277 HCl可抑制细胞生长并诱导凋亡。FTI 277 HCl可有效清除HDV病毒血症。	PLoS Biol,2021, 19(4):e3001134 Cell Struct Funct,2021, 46(1):1-9 Nat Commun,2019, 10(1):273	(A) HCT 116 cells were treated with Tram (0, 30, or 60 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD. (B) SW480 and MDA-MB-231 cells were treated with Tram (0, 80, 160 nM), and then treated with 10 μM FTI-277/4 μM GGTI-298 or vehicle control for 48 hr. CCK8 assays were performed to assess cell proliferation and growth. The data from a representative example of three independent experiments are presented as the mean±SD.