Haspin Kinase
抑制剂选择性比较
Haspin Kinase产品
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2198 |
SGI-1776 free baseSGI-1776 free base是一种新型的,ATP竞争性Pim1抑制剂,无细胞试验中IC50为7 nM,比作用于Pim2和Pim3选择性分别高50和10倍,也有效作用于Flt3和haspin。SGI-1776 可诱导凋亡和自噬。Phase 1。 |
![]() ![]() VCaP cells were steroid starved overnight then treated with 10nM R1881 and PIM kinase inhibitor SGI-1776 as indicated for 4 hours. Total protein lysates were analyzed by Western blot with antibodies against P-AR S213, AR (total), P-4EBP1 Thr 37/46, and tubulin.
|
|
S3406 |
LDN-192960LDN-192960 (Compd 1) 是一种有效的 Haspin 和 Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) 的抑制剂,对应的IC50值分别为10 nM和48 nM。 |
目录号 | 产品描述 | 文献引用 | 实验数据 |
---|---|---|---|
S2198 |
SGI-1776 free baseSGI-1776 free base是一种新型的,ATP竞争性Pim1抑制剂,无细胞试验中IC50为7 nM,比作用于Pim2和Pim3选择性分别高50和10倍,也有效作用于Flt3和haspin。SGI-1776 可诱导凋亡和自噬。Phase 1。 |
![]() ![]() VCaP cells were steroid starved overnight then treated with 10nM R1881 and PIM kinase inhibitor SGI-1776 as indicated for 4 hours. Total protein lysates were analyzed by Western blot with antibodies against P-AR S213, AR (total), P-4EBP1 Thr 37/46, and tubulin.
|
|
S3406 |
LDN-192960LDN-192960 (Compd 1) 是一种有效的 Haspin 和 Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) 的抑制剂,对应的IC50值分别为10 nM和48 nM。 |